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Protein

Inositol polyphosphate multikinase

Gene

IPMK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4).2 Publications

Catalytic activityi

2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS07712-MONOMER.
BRENDAi2.7.1.151. 2681.
ReactomeiR-HSA-1855191. Synthesis of IPs in the nucleus.
SABIO-RKQ8NFU5.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol polyphosphate multikinase (EC:2.7.1.151)
Alternative name(s):
Inositol 1,3,4,6-tetrakisphosphate 5-kinase
Gene namesi
Name:IPMK
Synonyms:IMPK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:20739. IPMK.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi322 – 3232RK → QQ: Interferes with nuclear localization. 1 Publication
Mutagenesisi327 – 3282KK → QQ: Interferes with nuclear localization. 1 Publication

Organism-specific databases

PharmGKBiPA134903369.

Polymorphism and mutation databases

BioMutaiIPMK.
DMDMi50401072.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 416415Inositol polyphosphate multikinasePRO_0000066870Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei7 – 71PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8NFU5.
MaxQBiQ8NFU5.
PaxDbiQ8NFU5.
PRIDEiQ8NFU5.

PTM databases

iPTMnetiQ8NFU5.
PhosphoSiteiQ8NFU5.

Expressioni

Tissue specificityi

Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon.1 Publication

Gene expression databases

BgeeiQ8NFU5.
CleanExiHS_IPMK.
GenevisibleiQ8NFU5. HS.

Organism-specific databases

HPAiHPA037837.
HPA057542.

Interactioni

Protein-protein interaction databases

BioGridi128968. 1 interaction.
IntActiQ8NFU5. 1 interaction.
STRINGi9606.ENSP00000363046.

Structurei

3D structure databases

ProteinModelPortaliQ8NFU5.
SMRiQ8NFU5. Positions 81-262.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni140 – 1489Substrate bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi320 – 33011Nuclear localization signalAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1620. Eukaryota.
ENOG410YHQ3. LUCA.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000116306.
HOVERGENiHBG052124.
InParanoidiQ8NFU5.
KOiK00915.
OMAiEVEVRMI.
OrthoDBiEOG7KH9K3.
PhylomeDBiQ8NFU5.
TreeFamiTF321442.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 2 hits.
PfamiPF03770. IPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NFU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATEPPSPLR VEAPGPPEMR TSPAIESTPE GTPQPAGGRL RFLNGCVPLS
60 70 80 90 100
HQVAGHMYGK DKVGILQHPD GTVLKQLQPP PRGPRELEFY NMVYAADCFD
110 120 130 140 150
GVLLELRKYL PKYYGIWSPP TAPNDLYLKL EDVTHKFNKP CIMDVKIGQK
160 170 180 190 200
SYDPFASSEK IQQQVSKYPL MEEIGFLVLG MRVYHVHSDS YETENQHYGR
210 220 230 240 250
SLTKETIKDG VSRFFHNGYC LRKDAVAASI QKIEKILQWF ENQKQLNFYA
260 270 280 290 300
SSLLFVYEGS SQPTTTKLND RTLAEKFLSK GQLSDTEVLE YNNNFHVLSS
310 320 330 340 350
TANGKIESSV GKSLSKMYAR HRKIYTKKHH SQTSLKVENL EQDNGWKSMS
360 370 380 390 400
QEHLNGNVLS QLEKVFYHLP TGCQEIAEVE VRMIDFAHVF PSNTIDEGYV
410
YGLKHLISVL RSILDN
Length:416
Mass (Da):47,222
Last modified:October 1, 2002 - v1
Checksum:i622D678696A892F9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti349 – 3491M → I.
Corresponds to variant rs2275443 [ dbSNP | Ensembl ].
VAR_022112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF432853 mRNA. Translation: AAM97838.1.
BK000580 mRNA. Translation: DAA01362.1.
BC065709 mRNA. Translation: AAH65709.1.
CCDSiCCDS7250.1.
RefSeqiNP_689416.1. NM_152230.4.
UniGeneiHs.30280.

Genome annotation databases

EnsembliENST00000373935; ENSP00000363046; ENSG00000151151.
GeneIDi253430.
KEGGihsa:253430.
UCSCiuc001jkb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF432853 mRNA. Translation: AAM97838.1.
BK000580 mRNA. Translation: DAA01362.1.
BC065709 mRNA. Translation: AAH65709.1.
CCDSiCCDS7250.1.
RefSeqiNP_689416.1. NM_152230.4.
UniGeneiHs.30280.

3D structure databases

ProteinModelPortaliQ8NFU5.
SMRiQ8NFU5. Positions 81-262.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128968. 1 interaction.
IntActiQ8NFU5. 1 interaction.
STRINGi9606.ENSP00000363046.

PTM databases

iPTMnetiQ8NFU5.
PhosphoSiteiQ8NFU5.

Polymorphism and mutation databases

BioMutaiIPMK.
DMDMi50401072.

Proteomic databases

EPDiQ8NFU5.
MaxQBiQ8NFU5.
PaxDbiQ8NFU5.
PRIDEiQ8NFU5.

Protocols and materials databases

DNASUi253430.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373935; ENSP00000363046; ENSG00000151151.
GeneIDi253430.
KEGGihsa:253430.
UCSCiuc001jkb.3. human.

Organism-specific databases

CTDi253430.
GeneCardsiIPMK.
HGNCiHGNC:20739. IPMK.
HPAiHPA037837.
HPA057542.
MIMi609851. gene.
neXtProtiNX_Q8NFU5.
PharmGKBiPA134903369.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1620. Eukaryota.
ENOG410YHQ3. LUCA.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000116306.
HOVERGENiHBG052124.
InParanoidiQ8NFU5.
KOiK00915.
OMAiEVEVRMI.
OrthoDBiEOG7KH9K3.
PhylomeDBiQ8NFU5.
TreeFamiTF321442.

Enzyme and pathway databases

BioCyciMetaCyc:HS07712-MONOMER.
BRENDAi2.7.1.151. 2681.
ReactomeiR-HSA-1855191. Synthesis of IPs in the nucleus.
SABIO-RKQ8NFU5.

Miscellaneous databases

GenomeRNAii253430.
NextBioi92097.
PROiQ8NFU5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NFU5.
CleanExiHS_IPMK.
GenevisibleiQ8NFU5. HS.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 2 hits.
PfamiPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization."
    Nalaskowski M.M., Deschermeier C., Fanick W., Mayr G.W.
    Biochem. J. 366:549-556(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, MUTAGENESIS OF 322-ARG-LYS-323 AND 327-LYS-LYS-328, SUBCELLULAR LOCATION.
  2. "The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase."
    Chang S.-C., Miller A.L., Feng Y., Wente S.R., Majerus P.W.
    J. Biol. Chem. 277:43836-43843(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIPMK_HUMAN
AccessioniPrimary (citable) accession number: Q8NFU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.