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Protein

Inositol polyphosphate multikinase

Gene

IPMK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4).2 Publications

Catalytic activityi

2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS07712-MONOMER.
BRENDAi2.7.1.151. 2681.
ReactomeiR-HSA-1855191. Synthesis of IPs in the nucleus.
SABIO-RKiQ8NFU5.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol polyphosphate multikinase (EC:2.7.1.151)
Alternative name(s):
Inositol 1,3,4,6-tetrakisphosphate 5-kinase
Gene namesi
Name:IPMK
Synonyms:IMPK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000151151.5.
HGNCiHGNC:20739. IPMK.
MIMi609851. gene.
neXtProtiNX_Q8NFU5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi322 – 323RK → QQ: Interferes with nuclear localization. 1 Publication2
Mutagenesisi327 – 328KK → QQ: Interferes with nuclear localization. 1 Publication2

Organism-specific databases

DisGeNETi253430.
MalaCardsiIPMK.
OpenTargetsiENSG00000151151.
PharmGKBiPA134903369.

Polymorphism and mutation databases

BioMutaiIPMK.
DMDMi50401072.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000668702 – 416Inositol polyphosphate multikinaseAdd BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei7PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8NFU5.
MaxQBiQ8NFU5.
PaxDbiQ8NFU5.
PeptideAtlasiQ8NFU5.
PRIDEiQ8NFU5.

PTM databases

iPTMnetiQ8NFU5.
PhosphoSitePlusiQ8NFU5.

Expressioni

Tissue specificityi

Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon.1 Publication

Gene expression databases

BgeeiENSG00000151151.
CleanExiHS_IPMK.
GenevisibleiQ8NFU5. HS.

Organism-specific databases

HPAiHPA037837.
HPA057542.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HSF2BPO750314EBI-11347579,EBI-7116203

Protein-protein interaction databases

BioGridi128968. 1 interactor.
IntActiQ8NFU5. 2 interactors.
STRINGi9606.ENSP00000363046.

Structurei

Secondary structure

1416
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi66 – 68Combined sources3
Turni69 – 71Combined sources3
Beta strandi72 – 76Combined sources5
Turni79 – 81Combined sources3
Helixi82 – 93Combined sources12
Helixi101 – 106Combined sources6
Helixi107 – 109Combined sources3
Beta strandi113 – 117Combined sources5
Beta strandi127 – 131Combined sources5
Turni133 – 136Combined sources4
Beta strandi138 – 149Combined sources12
Helixi158 – 167Combined sources10
Helixi171 – 174Combined sources4
Beta strandi175 – 185Combined sources11
Turni186 – 189Combined sources4
Beta strandi190 – 194Combined sources5
Helixi196 – 200Combined sources5
Turni204 – 206Combined sources3
Helixi207 – 212Combined sources6
Helixi213 – 215Combined sources3
Beta strandi218 – 221Combined sources4
Helixi223 – 241Combined sources19
Beta strandi245 – 258Combined sources14
Beta strandi379 – 384Combined sources6
Beta strandi389 – 391Combined sources3
Helixi397 – 413Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5W2GX-ray1.80A50-262[»]
A378-416[»]
5W2HX-ray1.90A50-262[»]
A378-416[»]
5W2IX-ray1.60A50-262[»]
A378-416[»]
ProteinModelPortaliQ8NFU5.
SMRiQ8NFU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni140 – 148Substrate bindingBy similarity9

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi320 – 330Nuclear localization signalAdd BLAST11

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1620. Eukaryota.
ENOG410YHQ3. LUCA.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000116306.
HOVERGENiHBG052124.
InParanoidiQ8NFU5.
KOiK00915.
OMAiNTIDEGY.
OrthoDBiEOG091G0KJW.
PhylomeDBiQ8NFU5.
TreeFamiTF321442.

Family and domain databases

Gene3Di1.10.510.50. 2 hits.
InterProiView protein in InterPro
IPR005522. IPK.
IPR038286. IPK_sf.
PANTHERiPTHR12400. PTHR12400. 1 hit.
PfamiView protein in Pfam
PF03770. IPK. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NFU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATEPPSPLR VEAPGPPEMR TSPAIESTPE GTPQPAGGRL RFLNGCVPLS
60 70 80 90 100
HQVAGHMYGK DKVGILQHPD GTVLKQLQPP PRGPRELEFY NMVYAADCFD
110 120 130 140 150
GVLLELRKYL PKYYGIWSPP TAPNDLYLKL EDVTHKFNKP CIMDVKIGQK
160 170 180 190 200
SYDPFASSEK IQQQVSKYPL MEEIGFLVLG MRVYHVHSDS YETENQHYGR
210 220 230 240 250
SLTKETIKDG VSRFFHNGYC LRKDAVAASI QKIEKILQWF ENQKQLNFYA
260 270 280 290 300
SSLLFVYEGS SQPTTTKLND RTLAEKFLSK GQLSDTEVLE YNNNFHVLSS
310 320 330 340 350
TANGKIESSV GKSLSKMYAR HRKIYTKKHH SQTSLKVENL EQDNGWKSMS
360 370 380 390 400
QEHLNGNVLS QLEKVFYHLP TGCQEIAEVE VRMIDFAHVF PSNTIDEGYV
410
YGLKHLISVL RSILDN
Length:416
Mass (Da):47,222
Last modified:October 1, 2002 - v1
Checksum:i622D678696A892F9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022112349M → I. Corresponds to variant dbSNP:rs2275443Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF432853 mRNA. Translation: AAM97838.1.
BK000580 mRNA. Translation: DAA01362.1.
BC065709 mRNA. Translation: AAH65709.1.
CCDSiCCDS7250.1.
RefSeqiNP_689416.1. NM_152230.4.
UniGeneiHs.30280.

Genome annotation databases

EnsembliENST00000373935; ENSP00000363046; ENSG00000151151.
GeneIDi253430.
KEGGihsa:253430.
UCSCiuc001jkb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIPMK_HUMAN
AccessioniPrimary (citable) accession number: Q8NFU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome