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Protein

Follicular dendritic cell secreted peptide

Gene

FDCSP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Follicular dendritic cell secreted peptide
Short name:
FDC secreted protein
Short name:
FDC-SP
Gene namesi
Name:FDCSP
Synonyms:C4orf7
ORF Names:UNQ733/PRO1419
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000181617.5
HGNCiHGNC:19215 FDCSP
MIMi607241 gene
neXtProtiNX_Q8NFU4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi260436
OpenTargetsiENSG00000181617
PharmGKBiPA134922601

Polymorphism and mutation databases

BioMutaiFDCSP

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002124718 – 85Follicular dendritic cell secreted peptideAdd BLAST68

Post-translational modificationi

O-glycosylated with core 1 or possibly core 8 glycans.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NFU4
PeptideAtlasiQ8NFU4
PRIDEiQ8NFU4
ProteomicsDBi73361

PTM databases

iPTMnetiQ8NFU4
PhosphoSitePlusiQ8NFU4

Expressioni

Tissue specificityi

Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon.1 Publication

Gene expression databases

BgeeiENSG00000181617
CleanExiHS_C4orf7
ExpressionAtlasiQ8NFU4 baseline and differential
GenevisibleiQ8NFU4 HS

Organism-specific databases

HPAiCAB014890
HPA014326

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ASPHQ12797-64EBI-12210457,EBI-12092171

Protein-protein interaction databases

IntActiQ8NFU4, 3 interactors
STRINGi9606.ENSP00000318437

Structurei

3D structure databases

ProteinModelPortaliQ8NFU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni75 – 83O-glycosylated at one site9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi45 – 82Pro-richAdd BLAST38

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J707 Eukaryota
ENOG41114IU LUCA
GeneTreeiENSGT00390000015551
HOGENOMiHOG000112564
HOVERGENiHBG051603
InParanoidiQ8NFU4
OMAiFRPFPPI
PhylomeDBiQ8NFU4
TreeFamiTF338548

Family and domain databases

InterProiView protein in InterPro
IPR029187 FDC-SP
PfamiView protein in Pfam
PF15215 FDC-SP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NFU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVLLLITA ILAVAVGFPV SQDQEREKRS ISDSDELASG FFVFPYPYPF
60 70 80
RPLPPIPFPR FPWFRRNFPI PIPESAPTTP LPSEK
Length:85
Mass (Da):9,700
Last modified:October 1, 2002 - v1
Checksum:i3FEC98BDE883AB07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF435080 mRNA Translation: AAN01116.1
AY358958 mRNA Translation: AAQ89317.1
BC062213 mRNA Translation: AAH62213.1
CCDSiCCDS3537.1
RefSeqiNP_694542.1, NM_152997.3
UniGeneiHs.733448

Genome annotation databases

EnsembliENST00000317987; ENSP00000318437; ENSG00000181617
GeneIDi260436
KEGGihsa:260436
UCSCiuc003hfd.4 human

Similar proteinsi

Entry informationi

Entry nameiFDSCP_HUMAN
AccessioniPrimary (citable) accession number: Q8NFU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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