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Protein

Follicular dendritic cell secreted peptide

Gene

FDCSP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181617-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Follicular dendritic cell secreted peptide
Short name:
FDC secreted protein
Short name:
FDC-SP
Gene namesi
Name:FDCSP
Synonyms:C4orf7
ORF Names:UNQ733/PRO1419
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:19215. FDCSP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi260436.
OpenTargetsiENSG00000181617.
PharmGKBiPA134922601.

Polymorphism and mutation databases

BioMutaiFDCSP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002124718 – 85Follicular dendritic cell secreted peptideAdd BLAST68

Post-translational modificationi

O-glycosylated with core 1 or possibly core 8 glycans.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NFU4.
PeptideAtlasiQ8NFU4.
PRIDEiQ8NFU4.

PTM databases

iPTMnetiQ8NFU4.
PhosphoSitePlusiQ8NFU4.

Expressioni

Tissue specificityi

Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon.1 Publication

Gene expression databases

BgeeiENSG00000181617.
CleanExiHS_C4orf7.
ExpressionAtlasiQ8NFU4. baseline and differential.
GenevisibleiQ8NFU4. HS.

Organism-specific databases

HPAiCAB014890.
HPA014326.

Interactioni

Protein-protein interaction databases

IntActiQ8NFU4. 1 interactor.
STRINGi9606.ENSP00000318437.

Structurei

3D structure databases

ProteinModelPortaliQ8NFU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni75 – 83O-glycosylated at one site9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi45 – 82Pro-richAdd BLAST38

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J707. Eukaryota.
ENOG41114IU. LUCA.
GeneTreeiENSGT00390000015551.
HOGENOMiHOG000112564.
HOVERGENiHBG051603.
InParanoidiQ8NFU4.
OMAiFPYPYPF.
PhylomeDBiQ8NFU4.
TreeFamiTF338548.

Family and domain databases

InterProiIPR029187. FDC-SP.
[Graphical view]
PfamiPF15215. FDC-SP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NFU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVLLLITA ILAVAVGFPV SQDQEREKRS ISDSDELASG FFVFPYPYPF
60 70 80
RPLPPIPFPR FPWFRRNFPI PIPESAPTTP LPSEK
Length:85
Mass (Da):9,700
Last modified:October 1, 2002 - v1
Checksum:i3FEC98BDE883AB07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF435080 mRNA. Translation: AAN01116.1.
AY358958 mRNA. Translation: AAQ89317.1.
BC062213 mRNA. Translation: AAH62213.1.
CCDSiCCDS3537.1.
RefSeqiNP_694542.1. NM_152997.3.
UniGeneiHs.733448.

Genome annotation databases

EnsembliENST00000317987; ENSP00000318437; ENSG00000181617.
GeneIDi260436.
KEGGihsa:260436.
UCSCiuc003hfd.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF435080 mRNA. Translation: AAN01116.1.
AY358958 mRNA. Translation: AAQ89317.1.
BC062213 mRNA. Translation: AAH62213.1.
CCDSiCCDS3537.1.
RefSeqiNP_694542.1. NM_152997.3.
UniGeneiHs.733448.

3D structure databases

ProteinModelPortaliQ8NFU4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8NFU4. 1 interactor.
STRINGi9606.ENSP00000318437.

PTM databases

iPTMnetiQ8NFU4.
PhosphoSitePlusiQ8NFU4.

Polymorphism and mutation databases

BioMutaiFDCSP.

Proteomic databases

PaxDbiQ8NFU4.
PeptideAtlasiQ8NFU4.
PRIDEiQ8NFU4.

Protocols and materials databases

DNASUi260436.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317987; ENSP00000318437; ENSG00000181617.
GeneIDi260436.
KEGGihsa:260436.
UCSCiuc003hfd.4. human.

Organism-specific databases

CTDi260436.
DisGeNETi260436.
GeneCardsiFDCSP.
HGNCiHGNC:19215. FDCSP.
HPAiCAB014890.
HPA014326.
MIMi607241. gene.
neXtProtiNX_Q8NFU4.
OpenTargetsiENSG00000181617.
PharmGKBiPA134922601.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J707. Eukaryota.
ENOG41114IU. LUCA.
GeneTreeiENSGT00390000015551.
HOGENOMiHOG000112564.
HOVERGENiHBG051603.
InParanoidiQ8NFU4.
OMAiFPYPYPF.
PhylomeDBiQ8NFU4.
TreeFamiTF338548.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181617-MONOMER.

Miscellaneous databases

GenomeRNAii260436.
PROiQ8NFU4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181617.
CleanExiHS_C4orf7.
ExpressionAtlasiQ8NFU4. baseline and differential.
GenevisibleiQ8NFU4. HS.

Family and domain databases

InterProiIPR029187. FDC-SP.
[Graphical view]
PfamiPF15215. FDC-SP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFDSCP_HUMAN
AccessioniPrimary (citable) accession number: Q8NFU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.