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Protein

Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1

Gene

TSTD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Possible role in tumorigenesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei79 – 791Cysteine persulfide intermediatePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1
Gene namesi
Name:TSTD1
Synonyms:KAT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:35410. TSTD1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • mitochondrion Source: Ensembl
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165752768.

Polymorphism and mutation databases

BioMutaiTSTD1.
DMDMi68051988.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 115114Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1PRO_0000139423Add
BLAST

Proteomic databases

EPDiQ8NFU3.
MaxQBiQ8NFU3.
PaxDbiQ8NFU3.
PeptideAtlasiQ8NFU3.
PRIDEiQ8NFU3.
TopDownProteomicsiQ8NFU3-1. [Q8NFU3-1]

PTM databases

iPTMnetiQ8NFU3.
PhosphoSiteiQ8NFU3.
SwissPalmiQ8NFU3.

Expressioni

Tissue specificityi

Highly expressed in kidney, liver and skeletal muscle. Lower levels of expression in heart, colon, thymus, spleen, placenta and lung. Weakly expressed in brain, small intestine and peripheral blood leukocytes. Expressed at high levels in the breast carcinoma cell lines MCF-7 and MDA-MB-468 and at a lower level in the breast carcinoma cell line MDA-MB-231, the colon carcinoma call line LoVo and the lung carcinoma cell line A-549. No expression in the cell lines EFO-27 and HeLa, or the normal breast tissue cell lines MCF-10A and H184A1. Detected in invasive ductal carcinoma, but not in the adjacent tissues.1 Publication

Gene expression databases

BgeeiENSG00000215845.
ExpressionAtlasiQ8NFU3. baseline and differential.
GenevisibleiQ8NFU3. HS.

Organism-specific databases

HPAiHPA006655.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000388293.

Structurei

3D structure databases

ProteinModelPortaliQ8NFU3.
SMRiQ8NFU3. Positions 23-110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 11599RhodanesePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 rhodanese domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1530. Eukaryota.
COG0607. LUCA.
GeneTreeiENSGT00510000047949.
HOVERGENiHBG107354.
InParanoidiQ8NFU3.
OMAiSINVPYR.
OrthoDBiEOG091G124L.
PhylomeDBiQ8NFU3.
TreeFamiTF323321.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR001763. Rhodanese-like_dom.
[Graphical view]
PfamiPF00581. Rhodanese. 1 hit.
[Graphical view]
SMARTiSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q8NFU3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGAPTVSLP ELRSLLASGR ARLFDVRSRE EAAAGTIPGA LNIPVSELES
60 70 80 90 100
ALQMEPAAFQ ALYSAEKPKL EDEHLVFFCQ MGKRGLQATQ LARSLGYTGA
110
RNYAGAYREW LEKES
Length:115
Mass (Da):12,530
Last modified:January 23, 2007 - v3
Checksum:i01963F5B8186B3A2
GO
Isoform 21 Publication (identifier: Q8NFU3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4-44: Missing.

Show »
Length:74
Mass (Da):8,274
Checksum:iE6BF433F3A12274B
GO
Isoform 31 Publication (identifier: Q8NFU3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     100-115: ARNYAGAYREWLEKES → YGEVWLLAGR

Show »
Length:109
Mass (Da):11,750
Checksum:i8BB14CF3EA5223F4
GO
Isoform 4 (identifier: Q8NFU3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-3: G → GGCRAPSS

Note: No experimental confirmation available.Curated
Show »
Length:122
Mass (Da):13,189
Checksum:iE86B87A07C62B477
GO

Sequence cautioni

The sequence AAH01699 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAI15368 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI15369 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei3 – 31G → GGCRAPSS in isoform 4. CuratedVSP_014151
Alternative sequencei4 – 4441Missing in isoform 2. CuratedVSP_014152Add
BLAST
Alternative sequencei100 – 11516ARNYA…LEKES → YGEVWLLAGR in isoform 3. 1 PublicationVSP_014153Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF439442 Genomic DNA. Translation: AAM69839.1.
AF439442 Genomic DNA. Translation: AAM69840.1.
AL591806 Genomic DNA. Translation: CAI15367.1.
AL591806 Genomic DNA. Translation: CAI15368.1. Sequence problems.
AL591806 Genomic DNA. Translation: CAI15369.1. Different initiation.
AL591806 Genomic DNA. Translation: CAI15370.1.
BC001699 mRNA. Translation: AAH01699.1. Different initiation.
CCDSiCCDS44257.1. [Q8NFU3-2]
CCDS44258.1. [Q8NFU3-3]
CCDS53400.1. [Q8NFU3-1]
RefSeqiNP_001106676.1. NM_001113205.1. [Q8NFU3-3]
NP_001106677.1. NM_001113206.1. [Q8NFU3-2]
NP_001106678.1. NM_001113207.1. [Q8NFU3-1]
UniGeneiHs.720030.

Genome annotation databases

EnsembliENST00000318289; ENSP00000325518; ENSG00000215845. [Q8NFU3-3]
ENST00000368023; ENSP00000357002; ENSG00000215845. [Q8NFU3-4]
ENST00000368024; ENSP00000357003; ENSG00000215845. [Q8NFU3-2]
ENST00000423014; ENSP00000388293; ENSG00000215845. [Q8NFU3-1]
GeneIDi100131187.
KEGGihsa:100131187.
UCSCiuc001fxh.5. human. [Q8NFU3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF439442 Genomic DNA. Translation: AAM69839.1.
AF439442 Genomic DNA. Translation: AAM69840.1.
AL591806 Genomic DNA. Translation: CAI15367.1.
AL591806 Genomic DNA. Translation: CAI15368.1. Sequence problems.
AL591806 Genomic DNA. Translation: CAI15369.1. Different initiation.
AL591806 Genomic DNA. Translation: CAI15370.1.
BC001699 mRNA. Translation: AAH01699.1. Different initiation.
CCDSiCCDS44257.1. [Q8NFU3-2]
CCDS44258.1. [Q8NFU3-3]
CCDS53400.1. [Q8NFU3-1]
RefSeqiNP_001106676.1. NM_001113205.1. [Q8NFU3-3]
NP_001106677.1. NM_001113206.1. [Q8NFU3-2]
NP_001106678.1. NM_001113207.1. [Q8NFU3-1]
UniGeneiHs.720030.

3D structure databases

ProteinModelPortaliQ8NFU3.
SMRiQ8NFU3. Positions 23-110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000388293.

PTM databases

iPTMnetiQ8NFU3.
PhosphoSiteiQ8NFU3.
SwissPalmiQ8NFU3.

Polymorphism and mutation databases

BioMutaiTSTD1.
DMDMi68051988.

Proteomic databases

EPDiQ8NFU3.
MaxQBiQ8NFU3.
PaxDbiQ8NFU3.
PeptideAtlasiQ8NFU3.
PRIDEiQ8NFU3.
TopDownProteomicsiQ8NFU3-1. [Q8NFU3-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318289; ENSP00000325518; ENSG00000215845. [Q8NFU3-3]
ENST00000368023; ENSP00000357002; ENSG00000215845. [Q8NFU3-4]
ENST00000368024; ENSP00000357003; ENSG00000215845. [Q8NFU3-2]
ENST00000423014; ENSP00000388293; ENSG00000215845. [Q8NFU3-1]
GeneIDi100131187.
KEGGihsa:100131187.
UCSCiuc001fxh.5. human. [Q8NFU3-1]

Organism-specific databases

CTDi100131187.
GeneCardsiTSTD1.
HGNCiHGNC:35410. TSTD1.
HPAiHPA006655.
MIMi616041. gene.
neXtProtiNX_Q8NFU3.
PharmGKBiPA165752768.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1530. Eukaryota.
COG0607. LUCA.
GeneTreeiENSGT00510000047949.
HOVERGENiHBG107354.
InParanoidiQ8NFU3.
OMAiSINVPYR.
OrthoDBiEOG091G124L.
PhylomeDBiQ8NFU3.
TreeFamiTF323321.

Miscellaneous databases

GenomeRNAii100131187.
PROiQ8NFU3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000215845.
ExpressionAtlasiQ8NFU3. baseline and differential.
GenevisibleiQ8NFU3. HS.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR001763. Rhodanese-like_dom.
[Graphical view]
PfamiPF00581. Rhodanese. 1 hit.
[Graphical view]
SMARTiSM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSTD1_HUMAN
AccessioniPrimary (citable) accession number: Q8NFU3
Secondary accession number(s): Q5SY48
, Q5SY49, Q5SY50, Q5SY51, Q8NFU2, Q9BV22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.