UniProtKB - Q8NFT8 (DNER_HUMAN)
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Protein
Delta and Notch-like epidermal growth factor-related receptor
Gene
DNER
Organism
Homo sapiens (Human)
Status
Functioni
Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).By similarity
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- clathrin binding Source: UniProtKB
- Notch binding Source: Ensembl
- transmembrane signaling receptor activity Source: UniProtKB
GO - Biological processi
- central nervous system development Source: UniProtKB
- endocytosis Source: UniProtKB
- glial cell differentiation Source: Ensembl
- neuron migration Source: UniProtKB
- Notch receptor processing Source: Ensembl
- Notch signaling pathway Source: UniProtKB-KW
- skeletal muscle fiber development Source: Ensembl
- synapse assembly Source: UniProtKB
Keywordsi
Molecular function | Activator, Receptor |
Biological process | Notch signaling pathway |
Ligand | Calcium |
Enzyme and pathway databases
Reactomei | R-HSA-2122948. Activated NOTCH1 Transmits Signal to the Nucleus. |
SignaLinki | Q8NFT8. |
SIGNORi | Q8NFT8. |
Names & Taxonomyi
Protein namesi | Recommended name: Delta and Notch-like epidermal growth factor-related receptor |
Gene namesi | Name:DNER Synonyms:BET ORF Names:UNQ262/PRO299 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000187957.7. |
HGNCi | HGNC:24456. DNER. |
MIMi | 607299. gene. |
neXtProti | NX_Q8NFT8. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 35 – 640 | ExtracellularSequence analysisAdd BLAST | 606 | |
Transmembranei | 641 – 661 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 662 – 737 | CytoplasmicSequence analysisAdd BLAST | 76 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 92737. |
OpenTargetsi | ENSG00000187957. |
PharmGKBi | PA162383959. |
Polymorphism and mutation databases
BioMutai | DNER. |
DMDMi | 74730301. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 34 | Sequence analysisAdd BLAST | 34 | |
ChainiPRO_0000253557 | 35 – 737 | Delta and Notch-like epidermal growth factor-related receptorAdd BLAST | 703 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 48 ↔ 59 | PROSITE-ProRule annotation | ||
Disulfide bondi | 53 ↔ 80 | PROSITE-ProRule annotation | ||
Disulfide bondi | 82 ↔ 91 | PROSITE-ProRule annotation | ||
Disulfide bondi | 98 ↔ 108 | PROSITE-ProRule annotation | ||
Disulfide bondi | 103 ↔ 121 | PROSITE-ProRule annotation | ||
Disulfide bondi | 123 ↔ 132 | PROSITE-ProRule annotation | ||
Glycosylationi | 223 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 319 ↔ 336 | PROSITE-ProRule annotation | ||
Disulfide bondi | 338 ↔ 347 | PROSITE-ProRule annotation | ||
Disulfide bondi | 353 ↔ 364 | PROSITE-ProRule annotation | ||
Disulfide bondi | 358 ↔ 378 | PROSITE-ProRule annotation | ||
Disulfide bondi | 380 ↔ 389 | PROSITE-ProRule annotation | ||
Disulfide bondi | 396 ↔ 407 | PROSITE-ProRule annotation | ||
Disulfide bondi | 401 ↔ 416 | PROSITE-ProRule annotation | ||
Disulfide bondi | 418 ↔ 427 | PROSITE-ProRule annotation | ||
Disulfide bondi | 434 ↔ 445 | PROSITE-ProRule annotation | ||
Disulfide bondi | 439 ↔ 454 | PROSITE-ProRule annotation | ||
Disulfide bondi | 456 ↔ 465 | PROSITE-ProRule annotation | ||
Disulfide bondi | 472 ↔ 482 | PROSITE-ProRule annotation | ||
Disulfide bondi | 477 ↔ 491 | PROSITE-ProRule annotation | ||
Disulfide bondi | 493 ↔ 502 | PROSITE-ProRule annotation | ||
Disulfide bondi | 509 ↔ 520 | PROSITE-ProRule annotation | ||
Disulfide bondi | 514 ↔ 529 | PROSITE-ProRule annotation | ||
Disulfide bondi | 531 ↔ 540 | PROSITE-ProRule annotation | ||
Disulfide bondi | 547 ↔ 558 | PROSITE-ProRule annotation | ||
Disulfide bondi | 552 ↔ 567 | PROSITE-ProRule annotation | ||
Glycosylationi | 564 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 569 ↔ 578 | PROSITE-ProRule annotation | ||
Disulfide bondi | 585 ↔ 596 | PROSITE-ProRule annotation | ||
Disulfide bondi | 590 ↔ 605 | PROSITE-ProRule annotation | ||
Disulfide bondi | 607 ↔ 616 | PROSITE-ProRule annotation | ||
Modified residuei | 685 | PhosphoserineBy similarity | 1 | |
Modified residuei | 711 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 721 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 722 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | Q8NFT8. |
PaxDbi | Q8NFT8. |
PeptideAtlasi | Q8NFT8. |
PRIDEi | Q8NFT8. |
PTM databases
iPTMneti | Q8NFT8. |
PhosphoSitePlusi | Q8NFT8. |
Expressioni
Tissue specificityi
Expressed in brain, spinal cord and adrenal gland.1 Publication
Gene expression databases
Bgeei | ENSG00000187957. |
Genevisiblei | Q8NFT8. HS. |
Organism-specific databases
HPAi | HPA017320. |
Interactioni
Subunit structurei
Interacts with AP1G1. Interacts with NOTCH1 (By similarity).By similarity
GO - Molecular functioni
- clathrin binding Source: UniProtKB
- Notch binding Source: Ensembl
Protein-protein interaction databases
BioGridi | 124973. 1 interactor. |
DIPi | DIP-46249N. |
IntActi | Q8NFT8. 3 interactors. |
STRINGi | 9606.ENSP00000345229. |
Structurei
3D structure databases
ProteinModelPortali | Q8NFT8. |
SMRi | Q8NFT8. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 92 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 49 | |
Domaini | 94 – 133 | EGF-like 2PROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 309 – 348 | EGF-like 3PROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 349 – 390 | EGF-like 4PROSITE-ProRule annotationAdd BLAST | 42 | |
Domaini | 392 – 428 | EGF-like 5PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 430 – 466 | EGF-like 6PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 468 – 503 | EGF-like 7PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 505 – 541 | EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 543 – 579 | EGF-like 9PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 546 – 568 | Follistatin-likeAdd BLAST | 23 | |
Domaini | 581 – 617 | EGF-like 10; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 44 – 133 | Interaction with NOTCH1By similarityAdd BLAST | 90 | |
Regioni | 677 – 680 | Interaction with AP1G1 and somatodendritic targetingBy similarity | 4 |
Keywords - Domaini
EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IR71. Eukaryota. ENOG410ZUAK. LUCA. |
GeneTreei | ENSGT00910000144018. |
HOVERGENi | HBG060866. |
InParanoidi | Q8NFT8. |
OMAi | KDPCANV. |
OrthoDBi | EOG091G01VZ. |
PhylomeDBi | Q8NFT8. |
TreeFami | TF351322. |
Family and domain databases
InterProi | View protein in InterPro IPR001881. EGF-like_Ca-bd_dom. IPR013032. EGF-like_CS. IPR000742. EGF-like_dom. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR018097. EGF_Ca-bd_CS. IPR009030. Growth_fac_rcpt_cys_sf. |
Pfami | View protein in Pfam PF00008. EGF. 6 hits. PF12661. hEGF. 1 hit. |
SMARTi | View protein in SMART SM00181. EGF. 10 hits. SM00179. EGF_CA. 7 hits. |
SUPFAMi | SSF57184. SSF57184. 2 hits. |
PROSITEi | View protein in PROSITE PS00010. ASX_HYDROXYL. 2 hits. PS00022. EGF_1. 10 hits. PS01186. EGF_2. 7 hits. PS50026. EGF_3. 10 hits. PS01187. EGF_CA. 2 hits. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8NFT8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQPRRAQAPG AQLLPALALL LLLLGAGPRG SSLANPVPAA PLSAPGPCAA
60 70 80 90 100
QPCRNGGVCT SRPEPDPQHP APAGEPGYSC TCPAGISGAN CQLVADPCAS
110 120 130 140 150
NPCHHGNCSS SSSSSSDGYL CICNEGYEGP NCEQALPSLP ATGWTESMAP
160 170 180 190 200
RQLQPVPATQ EPDKILPRSQ ATVTLPTWQP KTGQKVVEMK WDQVEVIPDI
210 220 230 240 250
ACGNASSNSS AGGRLVSFEV PQNTSVKIRQ DATASLILLW KVTATGFQQC
260 270 280 290 300
SLIDGRSVTP LQASGGLVLL EEMLALGNNH FIGFVNDSVT KSIVALRLTL
310 320 330 340 350
VVKVSTCVPG ESHANDLECS GKGKCTTKPS EATFSCTCEE QYVGTFCEEY
360 370 380 390 400
DACQRKPCQN NASCIDANEK QDGSNFTCVC LPGYTGELCQ SKIDYCILDP
410 420 430 440 450
CRNGATCISS LSGFTCQCPE GYFGSACEEK VDPCASSPCQ NNGTCYVDGV
460 470 480 490 500
HFTCNCSPGF TGPTCAQLID FCALSPCAHG TCRSVGTSYK CLCDPGYHGL
510 520 530 540 550
YCEEEYNECL SAPCLNAATC RDLVNGYECV CLAEYKGTHC ELYKDPCANV
560 570 580 590 600
SCLNGATCDS DGLNGTCICA PGFTGEECDI DINECDSNPC HHGGSCLDQP
610 620 630 640 650
NGYNCHCPHG WVGANCEIHL QWKSGHMAES LTNMPRHSLY IIIGALCVAF
660 670 680 690 700
ILMLIILIVG ICRISRIEYQ GSSRPAYEEF YNCRSIDSEF SNAIASIRHA
710 720 730
RFGKKSRPAM YDVSPIAYED YSPDDKPLVT LIKTKDL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028380 | 433 | P → L1 PublicationCorresponds to variant dbSNP:rs17853365Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF442487 mRNA. Translation: AAM21557.1. AY358891 mRNA. Translation: AAQ89250.1. AC007559 Genomic DNA. Translation: AAY14939.1. AC007748 Genomic DNA. Translation: AAY24263.1. AC008273 Genomic DNA. Translation: AAF19247.2. AC093384 Genomic DNA. Translation: AAY14680.1. CH471063 Genomic DNA. Translation: EAW70893.1. BC024766 mRNA. Translation: AAH24766.2. BC035009 mRNA. Translation: AAH35009.1. AL137311 mRNA. Translation: CAB70690.1. |
CCDSi | CCDS33390.1. |
PIRi | T46247. |
RefSeqi | NP_620711.3. NM_139072.3. |
UniGenei | Hs.234074. |
Genome annotation databases
Ensembli | ENST00000341772; ENSP00000345229; ENSG00000187957. |
GeneIDi | 92737. |
KEGGi | hsa:92737. |
UCSCi | uc002vpv.4. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | DNER_HUMAN | |
Accessioni | Q8NFT8Primary (citable) accession number: Q8NFT8 Secondary accession number(s): A6NP39 Q9UDM2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | October 1, 2002 | |
Last modified: | March 28, 2018 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |