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Protein

Delta and Notch-like epidermal growth factor-related receptor

Gene

DNER

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).By similarity

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • clathrin binding Source: UniProtKB
  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

  • central nervous system development Source: UniProtKB
  • endocytosis Source: UniProtKB
  • glial cell differentiation Source: Ensembl
  • neuron migration Source: UniProtKB
  • Notch receptor processing Source: Ensembl
  • Notch signaling pathway Source: UniProtKB-KW
  • skeletal muscle fiber development Source: Ensembl
  • synapse assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor

Keywords - Biological processi

Notch signaling pathway

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-HSA-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
SignaLinkiQ8NFT8.
SIGNORiQ8NFT8.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta and Notch-like epidermal growth factor-related receptor
Gene namesi
Name:DNER
Synonyms:BET
ORF Names:UNQ262/PRO299
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24456. DNER.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 640606ExtracellularSequence analysisAdd
BLAST
Transmembranei641 – 66121HelicalSequence analysisAdd
BLAST
Topological domaini662 – 73776CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • dendrite Source: UniProtKB
  • early endosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: Ensembl
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162383959.

Polymorphism and mutation databases

BioMutaiDNER.
DMDMi74730301.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence analysisAdd
BLAST
Chaini35 – 737703Delta and Notch-like epidermal growth factor-related receptorPRO_0000253557Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi48 ↔ 59PROSITE-ProRule annotation
Disulfide bondi53 ↔ 80PROSITE-ProRule annotation
Disulfide bondi82 ↔ 91PROSITE-ProRule annotation
Disulfide bondi98 ↔ 108PROSITE-ProRule annotation
Disulfide bondi103 ↔ 121PROSITE-ProRule annotation
Disulfide bondi123 ↔ 132PROSITE-ProRule annotation
Glycosylationi223 – 2231N-linked (GlcNAc...)1 Publication
Disulfide bondi319 ↔ 336PROSITE-ProRule annotation
Disulfide bondi338 ↔ 347PROSITE-ProRule annotation
Disulfide bondi353 ↔ 364PROSITE-ProRule annotation
Disulfide bondi358 ↔ 378PROSITE-ProRule annotation
Disulfide bondi380 ↔ 389PROSITE-ProRule annotation
Disulfide bondi396 ↔ 407PROSITE-ProRule annotation
Disulfide bondi401 ↔ 416PROSITE-ProRule annotation
Disulfide bondi418 ↔ 427PROSITE-ProRule annotation
Disulfide bondi434 ↔ 445PROSITE-ProRule annotation
Disulfide bondi439 ↔ 454PROSITE-ProRule annotation
Disulfide bondi456 ↔ 465PROSITE-ProRule annotation
Disulfide bondi472 ↔ 482PROSITE-ProRule annotation
Disulfide bondi477 ↔ 491PROSITE-ProRule annotation
Disulfide bondi493 ↔ 502PROSITE-ProRule annotation
Disulfide bondi509 ↔ 520PROSITE-ProRule annotation
Disulfide bondi514 ↔ 529PROSITE-ProRule annotation
Disulfide bondi531 ↔ 540PROSITE-ProRule annotation
Disulfide bondi547 ↔ 558PROSITE-ProRule annotation
Disulfide bondi552 ↔ 567PROSITE-ProRule annotation
Glycosylationi564 – 5641N-linked (GlcNAc...)Sequence analysis
Disulfide bondi569 ↔ 578PROSITE-ProRule annotation
Disulfide bondi585 ↔ 596PROSITE-ProRule annotation
Disulfide bondi590 ↔ 605PROSITE-ProRule annotation
Disulfide bondi607 ↔ 616PROSITE-ProRule annotation
Modified residuei685 – 6851PhosphoserineBy similarity
Modified residuei711 – 7111PhosphotyrosineBy similarity
Modified residuei721 – 7211PhosphotyrosineBy similarity
Modified residuei722 – 7221PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8NFT8.
PaxDbiQ8NFT8.
PRIDEiQ8NFT8.

PTM databases

iPTMnetiQ8NFT8.
PhosphoSiteiQ8NFT8.

Expressioni

Tissue specificityi

Expressed in brain, spinal cord and adrenal gland.1 Publication

Gene expression databases

BgeeiQ8NFT8.
GenevisibleiQ8NFT8. HS.

Organism-specific databases

HPAiHPA017320.

Interactioni

Subunit structurei

Interacts with AP1G1. Interacts with NOTCH1 (By similarity).By similarity

GO - Molecular functioni

  • clathrin binding Source: UniProtKB

Protein-protein interaction databases

DIPiDIP-46249N.
IntActiQ8NFT8. 1 interaction.
STRINGi9606.ENSP00000345229.

Structurei

3D structure databases

ProteinModelPortaliQ8NFT8.
SMRiQ8NFT8. Positions 48-136, 310-624.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 9249EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini94 – 13340EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini309 – 34840EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini349 – 39042EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini392 – 42837EGF-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini430 – 46637EGF-like 6PROSITE-ProRule annotationAdd
BLAST
Domaini468 – 50336EGF-like 7PROSITE-ProRule annotationAdd
BLAST
Domaini505 – 54137EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini543 – 57937EGF-like 9PROSITE-ProRule annotationAdd
BLAST
Domaini546 – 56823Follistatin-likeAdd
BLAST
Domaini581 – 61737EGF-like 10; calcium-bindingPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni44 – 13390Interaction with NOTCH1By similarityAdd
BLAST
Regioni677 – 6804Interaction with AP1G1 and somatodendritic targetingBy similarity

Sequence similaritiesi

Contains 10 EGF-like domains.PROSITE-ProRule annotation
Contains 1 follistatin-like domain.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR71. Eukaryota.
ENOG410ZUAK. LUCA.
GeneTreeiENSGT00840000129708.
HOVERGENiHBG060866.
InParanoidiQ8NFT8.
OMAiWDQVEVI.
OrthoDBiEOG7MPRD8.
PhylomeDBiQ8NFT8.
TreeFamiTF351322.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
[Graphical view]
PfamiPF00008. EGF. 7 hits.
PF12661. hEGF. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 10 hits.
SM00179. EGF_CA. 7 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS00022. EGF_1. 10 hits.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 10 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NFT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPRRAQAPG AQLLPALALL LLLLGAGPRG SSLANPVPAA PLSAPGPCAA
60 70 80 90 100
QPCRNGGVCT SRPEPDPQHP APAGEPGYSC TCPAGISGAN CQLVADPCAS
110 120 130 140 150
NPCHHGNCSS SSSSSSDGYL CICNEGYEGP NCEQALPSLP ATGWTESMAP
160 170 180 190 200
RQLQPVPATQ EPDKILPRSQ ATVTLPTWQP KTGQKVVEMK WDQVEVIPDI
210 220 230 240 250
ACGNASSNSS AGGRLVSFEV PQNTSVKIRQ DATASLILLW KVTATGFQQC
260 270 280 290 300
SLIDGRSVTP LQASGGLVLL EEMLALGNNH FIGFVNDSVT KSIVALRLTL
310 320 330 340 350
VVKVSTCVPG ESHANDLECS GKGKCTTKPS EATFSCTCEE QYVGTFCEEY
360 370 380 390 400
DACQRKPCQN NASCIDANEK QDGSNFTCVC LPGYTGELCQ SKIDYCILDP
410 420 430 440 450
CRNGATCISS LSGFTCQCPE GYFGSACEEK VDPCASSPCQ NNGTCYVDGV
460 470 480 490 500
HFTCNCSPGF TGPTCAQLID FCALSPCAHG TCRSVGTSYK CLCDPGYHGL
510 520 530 540 550
YCEEEYNECL SAPCLNAATC RDLVNGYECV CLAEYKGTHC ELYKDPCANV
560 570 580 590 600
SCLNGATCDS DGLNGTCICA PGFTGEECDI DINECDSNPC HHGGSCLDQP
610 620 630 640 650
NGYNCHCPHG WVGANCEIHL QWKSGHMAES LTNMPRHSLY IIIGALCVAF
660 670 680 690 700
ILMLIILIVG ICRISRIEYQ GSSRPAYEEF YNCRSIDSEF SNAIASIRHA
710 720 730
RFGKKSRPAM YDVSPIAYED YSPDDKPLVT LIKTKDL
Length:737
Mass (Da):78,475
Last modified:October 1, 2002 - v1
Checksum:i25A8A8A3044308BE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti433 – 4331P → L.1 Publication
Corresponds to variant rs17853365 [ dbSNP | Ensembl ].
VAR_028380

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF442487 mRNA. Translation: AAM21557.1.
AY358891 mRNA. Translation: AAQ89250.1.
AC007559 Genomic DNA. Translation: AAY14939.1.
AC007748 Genomic DNA. Translation: AAY24263.1.
AC008273 Genomic DNA. Translation: AAF19247.2.
AC093384 Genomic DNA. Translation: AAY14680.1.
CH471063 Genomic DNA. Translation: EAW70893.1.
BC024766 mRNA. Translation: AAH24766.2.
BC035009 mRNA. Translation: AAH35009.1.
AL137311 mRNA. Translation: CAB70690.1.
CCDSiCCDS33390.1.
PIRiT46247.
RefSeqiNP_620711.3. NM_139072.3.
UniGeneiHs.234074.

Genome annotation databases

EnsembliENST00000341772; ENSP00000345229; ENSG00000187957.
GeneIDi92737.
KEGGihsa:92737.
UCSCiuc002vpv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF442487 mRNA. Translation: AAM21557.1.
AY358891 mRNA. Translation: AAQ89250.1.
AC007559 Genomic DNA. Translation: AAY14939.1.
AC007748 Genomic DNA. Translation: AAY24263.1.
AC008273 Genomic DNA. Translation: AAF19247.2.
AC093384 Genomic DNA. Translation: AAY14680.1.
CH471063 Genomic DNA. Translation: EAW70893.1.
BC024766 mRNA. Translation: AAH24766.2.
BC035009 mRNA. Translation: AAH35009.1.
AL137311 mRNA. Translation: CAB70690.1.
CCDSiCCDS33390.1.
PIRiT46247.
RefSeqiNP_620711.3. NM_139072.3.
UniGeneiHs.234074.

3D structure databases

ProteinModelPortaliQ8NFT8.
SMRiQ8NFT8. Positions 48-136, 310-624.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46249N.
IntActiQ8NFT8. 1 interaction.
STRINGi9606.ENSP00000345229.

PTM databases

iPTMnetiQ8NFT8.
PhosphoSiteiQ8NFT8.

Polymorphism and mutation databases

BioMutaiDNER.
DMDMi74730301.

Proteomic databases

MaxQBiQ8NFT8.
PaxDbiQ8NFT8.
PRIDEiQ8NFT8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341772; ENSP00000345229; ENSG00000187957.
GeneIDi92737.
KEGGihsa:92737.
UCSCiuc002vpv.4. human.

Organism-specific databases

CTDi92737.
GeneCardsiDNER.
HGNCiHGNC:24456. DNER.
HPAiHPA017320.
MIMi607299. gene.
neXtProtiNX_Q8NFT8.
PharmGKBiPA162383959.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR71. Eukaryota.
ENOG410ZUAK. LUCA.
GeneTreeiENSGT00840000129708.
HOVERGENiHBG060866.
InParanoidiQ8NFT8.
OMAiWDQVEVI.
OrthoDBiEOG7MPRD8.
PhylomeDBiQ8NFT8.
TreeFamiTF351322.

Enzyme and pathway databases

ReactomeiR-HSA-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
SignaLinkiQ8NFT8.
SIGNORiQ8NFT8.

Miscellaneous databases

GeneWikiiDNER.
GenomeRNAii92737.
PROiQ8NFT8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NFT8.
GenevisibleiQ8NFT8. HS.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
[Graphical view]
PfamiPF00008. EGF. 7 hits.
PF12661. hEGF. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 10 hits.
SM00179. EGF_CA. 7 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS00022. EGF_1. 10 hits.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 10 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons."
    Eiraku M., Hirata Y., Takeshima H., Hirano T., Kengaku M.
    J. Biol. Chem. 277:25400-25407(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-433.
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 486-737.
    Tissue: Amygdala.
  7. "BET, a novel neuronal transmembrane protein with multiple EGF-like motifs."
    Nishizumi H., Komiyama T., Miyabayashi T., Sakano S., Sakano H.
    NeuroReport 13:909-915(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
    Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
    J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-223.
    Tissue: Saliva.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiDNER_HUMAN
AccessioniPrimary (citable) accession number: Q8NFT8
Secondary accession number(s): A6NP39
, Q53R88, Q53TP7, Q53TQ5, Q8IYT0, Q8TB42, Q9NTF1, Q9UDM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.