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Q8NFR9

- I17RE_HUMAN

UniProt

Q8NFR9 - I17RE_HUMAN

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Protein

Interleukin-17 receptor E

Gene
IL17RE, UNQ3056/PRO9877
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors.2 Publications

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17 receptor E
Short name:
IL-17 receptor E
Short name:
IL-17RE
Gene namesi
Name:IL17RE
ORF Names:UNQ3056/PRO9877
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:18439. IL17RE.

Subcellular locationi

Isoform 2 : Cytoplasm Inferred
Isoform 3 : Secreted Inferred
Isoform 4 : Cytoplasm Inferred
Isoform 5 : Secreted Inferred

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 454431Extracellular Reviewed predictionAdd
BLAST
Transmembranei455 – 47521Helical; Reviewed predictionAdd
BLAST
Topological domaini476 – 667192Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134896136.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 667644Interleukin-17 receptor EPRO_0000309467Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi318 – 3181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi347 – 3471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi364 – 3641N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NFR9.
PRIDEiQ8NFR9.

PTM databases

PhosphoSiteiQ8NFR9.

Expressioni

Tissue specificityi

Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines.2 Publications

Gene expression databases

ArrayExpressiQ8NFR9.
BgeeiQ8NFR9.
CleanExiHS_IL17RE.
GenevestigatoriQ8NFR9.

Organism-specific databases

HPAiHPA019011.

Interactioni

Subunit structurei

Forms heterodimers with IL17RA; the heterodimer binds IL17C.

Binary interactionsi

WithEntry#Exp.IntActNotes
IL17RAQ96F462EBI-5591275,EBI-5591258

Protein-protein interaction databases

IntActiQ8NFR9. 1 interaction.
STRINGi9606.ENSP00000295980.

Structurei

3D structure databases

ProteinModelPortaliQ8NFR9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini487 – 624138SEFIRAdd
BLAST

Sequence similaritiesi

Contains 1 SEFIR domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47803.
HOVERGENiHBG102913.
InParanoidiQ8NFR9.
KOiK05168.
PhylomeDBiQ8NFR9.
TreeFamiTF335690.

Family and domain databases

InterProiIPR027841. IL-17_rcpt_C/E_N.
IPR013568. SEFIR.
[Graphical view]
PfamiPF15037. IL17_R_N. 1 hit.
PF08357. SEFIR. 2 hits.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NFR9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGSSRLAALL LPLLLIVIDL SDSAGIGFRH LPHWNTRCPL ASHTDDSFTG    50
SSAYIPCRTW WALFSTKPWC VRVWHCSRCL CQHLLSGGSG LQRGLFHLLV 100
QKSKKSSTFK FYRRHKMPAP AQRKLLPRRH LSEKSHHISI PSPDISHKGL 150
RSKRTQPSDP ETWESLPRLD SQRHGGPEFS FDLLPEARAI RVTISSGPEV 200
SVRLCHQWAL ECEELSSPYD VQKIVSGGHT VELPYEFLLP CLCIEASYLQ 250
EDTVRRKKCP FQSWPEAYGS DFWKSVHFTD YSQHTQMVMA LTLRCPLKLE 300
AALCQRHDWH TLCKDLPNAT ARESDGWYVL EKVDLHPQLC FKFSFGNSSH 350
VECPHQTGSL TSWNVSMDTQ AQQLILHFSS RMHATFSAAW SLPGLGQDTL 400
VPPVYTVSQA RGSSPVSLDL IIPFLRPGCC VLVWRSDVQF AWKHLLCPDV 450
SYRHLGLLIL ALLALLTLLG VVLALTCRRP QSGPGPARPV LLLHAADSEA 500
QRRLVGALAE LLRAALGGGR DVIVDLWEGR HVARVGPLPW LWAARTRVAR 550
EQGTVLLLWS GADLRPVSGP DPRAAPLLAL LHAAPRPLLL LAYFSRLCAK 600
GDIPPPLRAL PRYRLLRDLP RLLRALDARP FAEATSWGRL GARQRRQSRL 650
ELCSRLEREA ARLADLG 667
Length:667
Mass (Da):74,810
Last modified:October 1, 2002 - v1
Checksum:i1493744E7354067D
GO
Isoform 2 (identifier: Q8NFR9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.

Show »
Length:551
Mass (Da):61,658
Checksum:i2A2B20E30F565006
GO
Isoform 3 (identifier: Q8NFR9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     433-533: VWRSDVQFAW...VDLWEGRHVA → LHASLSSPGG...GAAAPGGSAG
     534-667: Missing.

Show »
Length:533
Mass (Da):58,121
Checksum:i50C7F4E844688570
GO
Isoform 4 (identifier: Q8NFR9-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     433-506: VWRSDVQFAW...DSEAQRRLVG → ASSWSRHKPT...RMSLTDTWGS
     507-667: Missing.

Show »
Length:390
Mass (Da):43,699
Checksum:i31D49E817A1FC686
GO
Isoform 5 (identifier: Q8NFR9-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-271: YGSD → CECC
     272-667: Missing.

Note: No experimental confirmation available.

Show »
Length:271
Mass (Da):30,781
Checksum:i160836A0A928DBC8
GO

Sequence cautioni

Isoform 3 : The sequence BAB85028.1 differs from that shown. Reason: Frameshift at position 435.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti219 – 2191Y → C.
Corresponds to variant rs7356031 [ dbSNP | Ensembl ].
VAR_036956
Natural varianti402 – 4021P → S.
Corresponds to variant rs9870003 [ dbSNP | Ensembl ].
VAR_036957
Natural varianti417 – 4171S → T.
Corresponds to variant rs7647642 [ dbSNP | Ensembl ].
VAR_036958

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 116116Missing in isoform 2 and isoform 4. VSP_029190Add
BLAST
Alternative sequencei268 – 2714YGSD → CECC in isoform 5. VSP_029191
Alternative sequencei272 – 667396Missing in isoform 5. VSP_029192Add
BLAST
Alternative sequencei433 – 533101VWRSD…GRHVA → LHASLSSPGGEDAWLIGVGG SVPSGVAVRCPVCLEAPLVS GCLLQTPGALDPGTAGPPHP TGCCSGPHLPAPTVRPGPSA ASAPPARGGLGGAAAPGGSA G in isoform 3. VSP_029193Add
BLAST
Alternative sequencei433 – 50674VWRSD…RRLVG → ASSWSRHKPTWEEFPSQWGL PSPPAPCFTQLPGRRRCLAH RGGGLCALRCGGQMSSLPGS TSCVRMSLTDTWGS in isoform 4. VSP_029194Add
BLAST
Alternative sequencei507 – 667161Missing in isoform 4. VSP_029195Add
BLAST
Alternative sequencei534 – 667134Missing in isoform 3. VSP_029196Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti270 – 2701S → P in BAC04864. 1 Publication
Sequence conflicti445 – 4451L → F in BAC04864. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF458069 mRNA. Translation: AAM77573.1.
AY358451 mRNA. Translation: AAQ88816.1.
AK074238 mRNA. Translation: BAB85028.1. Frameshift.
AK096793 mRNA. Translation: BAC04863.1.
AK096801 mRNA. Translation: BAC04864.1.
AK314476 mRNA. Translation: BAG37081.1.
CH471055 Genomic DNA. Translation: EAW64019.1.
CH471055 Genomic DNA. Translation: EAW64020.1.
CH471055 Genomic DNA. Translation: EAW64016.1.
BC063110 mRNA. Translation: AAH63110.1.
BC137077 mRNA. Translation: AAI37078.1.
BC137078 mRNA. Translation: AAI37079.1.
CCDSiCCDS2589.1. [Q8NFR9-1]
CCDS54552.1. [Q8NFR9-3]
RefSeqiNP_001180309.1. NM_001193380.1. [Q8NFR9-3]
NP_705613.1. NM_153480.1. [Q8NFR9-1]
NP_705614.1. NM_153481.1. [Q8NFR9-2]
NP_705616.2. NM_153483.2.
XP_006713039.1. XM_006712976.1. [Q8NFR9-2]
UniGeneiHs.390823.

Genome annotation databases

EnsembliENST00000295980; ENSP00000295980; ENSG00000163701. [Q8NFR9-1]
ENST00000383814; ENSP00000373325; ENSG00000163701. [Q8NFR9-1]
ENST00000454190; ENSP00000388086; ENSG00000163701. [Q8NFR9-3]
GeneIDi132014.
KEGGihsa:132014.
UCSCiuc003btv.3. human. [Q8NFR9-5]
uc003btw.3. human. [Q8NFR9-1]
uc010hcq.3. human. [Q8NFR9-3]

Polymorphism databases

DMDMi74730297.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF458069 mRNA. Translation: AAM77573.1 .
AY358451 mRNA. Translation: AAQ88816.1 .
AK074238 mRNA. Translation: BAB85028.1 . Frameshift.
AK096793 mRNA. Translation: BAC04863.1 .
AK096801 mRNA. Translation: BAC04864.1 .
AK314476 mRNA. Translation: BAG37081.1 .
CH471055 Genomic DNA. Translation: EAW64019.1 .
CH471055 Genomic DNA. Translation: EAW64020.1 .
CH471055 Genomic DNA. Translation: EAW64016.1 .
BC063110 mRNA. Translation: AAH63110.1 .
BC137077 mRNA. Translation: AAI37078.1 .
BC137078 mRNA. Translation: AAI37079.1 .
CCDSi CCDS2589.1. [Q8NFR9-1 ]
CCDS54552.1. [Q8NFR9-3 ]
RefSeqi NP_001180309.1. NM_001193380.1. [Q8NFR9-3 ]
NP_705613.1. NM_153480.1. [Q8NFR9-1 ]
NP_705614.1. NM_153481.1. [Q8NFR9-2 ]
NP_705616.2. NM_153483.2.
XP_006713039.1. XM_006712976.1. [Q8NFR9-2 ]
UniGenei Hs.390823.

3D structure databases

ProteinModelPortali Q8NFR9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8NFR9. 1 interaction.
STRINGi 9606.ENSP00000295980.

PTM databases

PhosphoSitei Q8NFR9.

Polymorphism databases

DMDMi 74730297.

Proteomic databases

PaxDbi Q8NFR9.
PRIDEi Q8NFR9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295980 ; ENSP00000295980 ; ENSG00000163701 . [Q8NFR9-1 ]
ENST00000383814 ; ENSP00000373325 ; ENSG00000163701 . [Q8NFR9-1 ]
ENST00000454190 ; ENSP00000388086 ; ENSG00000163701 . [Q8NFR9-3 ]
GeneIDi 132014.
KEGGi hsa:132014.
UCSCi uc003btv.3. human. [Q8NFR9-5 ]
uc003btw.3. human. [Q8NFR9-1 ]
uc010hcq.3. human. [Q8NFR9-3 ]

Organism-specific databases

CTDi 132014.
GeneCardsi GC03P009944.
HGNCi HGNC:18439. IL17RE.
HPAi HPA019011.
MIMi 614995. gene.
neXtProti NX_Q8NFR9.
PharmGKBi PA134896136.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47803.
HOVERGENi HBG102913.
InParanoidi Q8NFR9.
KOi K05168.
PhylomeDBi Q8NFR9.
TreeFami TF335690.

Miscellaneous databases

GenomeRNAii 132014.
NextBioi 83006.
PROi Q8NFR9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8NFR9.
Bgeei Q8NFR9.
CleanExi HS_IL17RE.
Genevestigatori Q8NFR9.

Family and domain databases

InterProi IPR027841. IL-17_rcpt_C/E_N.
IPR013568. SEFIR.
[Graphical view ]
Pfami PF15037. IL17_R_N. 1 hit.
PF08357. SEFIR. 2 hits.
[Graphical view ]
PROSITEi PS51534. SEFIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel IL-17 related receptors."
    Gilbert J.M., Gorman D.M.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
    Tissue: Colon mucosa, Prostate and Small intestine.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
    Tissue: Lung, Skin and Testis.
  6. "Identification and functional characterization of a novel interleukin 17 receptor: a possible mitogenic activation through ras/mitogen-activated protein kinase signaling pathway."
    Li T.-S., Li X.-N., Chang Z.-J., Fu X.-Y., Liu L.
    Cell. Signal. 18:1287-1298(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens."
    Song X., Zhu S., Shi P., Liu Y., Shi Y., Levin S.D., Qian Y.
    Nat. Immunol. 12:1151-1158(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION AS IL17C RECEPTOR.
  8. Cited for: FUNCTION, IDENTIFICATION AS IL17C RECEPTOR, INTERACTION WITH IL17RA, TISSUE SPECIFICITY.

Entry informationi

Entry nameiI17RE_HUMAN
AccessioniPrimary (citable) accession number: Q8NFR9
Secondary accession number(s): B2RB34
, B2RNR1, B9EH65, Q6P532, Q8N8H7, Q8N8H8, Q8TEC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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