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Protein

Interleukin-17 receptor E

Gene

IL17RE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Inflammatory response

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163701-MONOMER.
ReactomeiR-HSA-448424. Interleukin-17 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17 receptor E
Short name:
IL-17 receptor E
Short name:
IL-17RE
Gene namesi
Name:IL17RE
ORF Names:UNQ3056/PRO9877
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:18439. IL17RE.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 454ExtracellularSequence analysisAdd BLAST431
Transmembranei455 – 475HelicalSequence analysisAdd BLAST21
Topological domaini476 – 667CytoplasmicSequence analysisAdd BLAST192

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi132014.
OpenTargetsiENSG00000163701.
PharmGKBiPA134896136.

Polymorphism and mutation databases

BioMutaiIL17RE.
DMDMi74730297.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000030946724 – 667Interleukin-17 receptor EAdd BLAST644

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi318N-linked (GlcNAc...)Sequence analysis1
Glycosylationi347N-linked (GlcNAc...)Sequence analysis1
Glycosylationi364N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NFR9.
PeptideAtlasiQ8NFR9.
PRIDEiQ8NFR9.

PTM databases

iPTMnetiQ8NFR9.
PhosphoSitePlusiQ8NFR9.

Expressioni

Tissue specificityi

Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines.2 Publications

Gene expression databases

BgeeiENSG00000163701.
CleanExiHS_IL17RE.
ExpressionAtlasiQ8NFR9. baseline and differential.
GenevisibleiQ8NFR9. HS.

Organism-specific databases

HPAiHPA019011.

Interactioni

Subunit structurei

Forms heterodimers with IL17RA; the heterodimer binds IL17C.

Binary interactionsi

WithEntry#Exp.IntActNotes
IL17RAQ96F462EBI-5591275,EBI-5591258

Protein-protein interaction databases

BioGridi126304. 9 interactors.
IntActiQ8NFR9. 1 interactor.
STRINGi9606.ENSP00000295980.

Structurei

3D structure databases

ProteinModelPortaliQ8NFR9.
SMRiQ8NFR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini487 – 624SEFIRPROSITE-ProRule annotationAdd BLAST138

Sequence similaritiesi

Contains 1 SEFIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFAR. Eukaryota.
ENOG410XTAY. LUCA.
GeneTreeiENSGT00730000111008.
HOVERGENiHBG102913.
InParanoidiQ8NFR9.
KOiK05168.
PhylomeDBiQ8NFR9.
TreeFamiTF335690.

Family and domain databases

InterProiIPR027841. IL-17_rcpt_C/E_N.
IPR013568. SEFIR_dom.
[Graphical view]
PfamiPF15037. IL17_R_N. 1 hit.
PF08357. SEFIR. 2 hits.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NFR9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSSRLAALL LPLLLIVIDL SDSAGIGFRH LPHWNTRCPL ASHTDDSFTG
60 70 80 90 100
SSAYIPCRTW WALFSTKPWC VRVWHCSRCL CQHLLSGGSG LQRGLFHLLV
110 120 130 140 150
QKSKKSSTFK FYRRHKMPAP AQRKLLPRRH LSEKSHHISI PSPDISHKGL
160 170 180 190 200
RSKRTQPSDP ETWESLPRLD SQRHGGPEFS FDLLPEARAI RVTISSGPEV
210 220 230 240 250
SVRLCHQWAL ECEELSSPYD VQKIVSGGHT VELPYEFLLP CLCIEASYLQ
260 270 280 290 300
EDTVRRKKCP FQSWPEAYGS DFWKSVHFTD YSQHTQMVMA LTLRCPLKLE
310 320 330 340 350
AALCQRHDWH TLCKDLPNAT ARESDGWYVL EKVDLHPQLC FKFSFGNSSH
360 370 380 390 400
VECPHQTGSL TSWNVSMDTQ AQQLILHFSS RMHATFSAAW SLPGLGQDTL
410 420 430 440 450
VPPVYTVSQA RGSSPVSLDL IIPFLRPGCC VLVWRSDVQF AWKHLLCPDV
460 470 480 490 500
SYRHLGLLIL ALLALLTLLG VVLALTCRRP QSGPGPARPV LLLHAADSEA
510 520 530 540 550
QRRLVGALAE LLRAALGGGR DVIVDLWEGR HVARVGPLPW LWAARTRVAR
560 570 580 590 600
EQGTVLLLWS GADLRPVSGP DPRAAPLLAL LHAAPRPLLL LAYFSRLCAK
610 620 630 640 650
GDIPPPLRAL PRYRLLRDLP RLLRALDARP FAEATSWGRL GARQRRQSRL
660
ELCSRLEREA ARLADLG
Length:667
Mass (Da):74,810
Last modified:October 1, 2002 - v1
Checksum:i1493744E7354067D
GO
Isoform 2 (identifier: Q8NFR9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.

Show »
Length:551
Mass (Da):61,658
Checksum:i2A2B20E30F565006
GO
Isoform 3 (identifier: Q8NFR9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     433-533: VWRSDVQFAW...VDLWEGRHVA → LHASLSSPGG...GAAAPGGSAG
     534-667: Missing.

Show »
Length:533
Mass (Da):58,121
Checksum:i50C7F4E844688570
GO
Isoform 4 (identifier: Q8NFR9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     433-506: VWRSDVQFAW...DSEAQRRLVG → ASSWSRHKPT...RMSLTDTWGS
     507-667: Missing.

Show »
Length:390
Mass (Da):43,699
Checksum:i31D49E817A1FC686
GO
Isoform 5 (identifier: Q8NFR9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-271: YGSD → CECC
     272-667: Missing.

Note: No experimental confirmation available.
Show »
Length:271
Mass (Da):30,781
Checksum:i160836A0A928DBC8
GO

Sequence cautioni

Isoform 3 : The sequence BAB85028 differs from that shown. Reason: Frameshift at position 435.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti270S → P in BAC04864 (PubMed:14702039).Curated1
Sequence conflicti445L → F in BAC04864 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036956219Y → C.Corresponds to variant rs7356031dbSNPEnsembl.1
Natural variantiVAR_036957402P → S.Corresponds to variant rs9870003dbSNPEnsembl.1
Natural variantiVAR_036958417S → T.Corresponds to variant rs7647642dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0291901 – 116Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_029191268 – 271YGSD → CECC in isoform 5. 1 Publication4
Alternative sequenceiVSP_029192272 – 667Missing in isoform 5. 1 PublicationAdd BLAST396
Alternative sequenceiVSP_029193433 – 533VWRSD…GRHVA → LHASLSSPGGEDAWLIGVGG SVPSGVAVRCPVCLEAPLVS GCLLQTPGALDPGTAGPPHP TGCCSGPHLPAPTVRPGPSA ASAPPARGGLGGAAAPGGSA G in isoform 3. 1 PublicationAdd BLAST101
Alternative sequenceiVSP_029194433 – 506VWRSD…RRLVG → ASSWSRHKPTWEEFPSQWGL PSPPAPCFTQLPGRRRCLAH RGGGLCALRCGGQMSSLPGS TSCVRMSLTDTWGS in isoform 4. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_029195507 – 667Missing in isoform 4. 1 PublicationAdd BLAST161
Alternative sequenceiVSP_029196534 – 667Missing in isoform 3. 1 PublicationAdd BLAST134

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF458069 mRNA. Translation: AAM77573.1.
AY358451 mRNA. Translation: AAQ88816.1.
AK074238 mRNA. Translation: BAB85028.1. Frameshift.
AK096793 mRNA. Translation: BAC04863.1.
AK096801 mRNA. Translation: BAC04864.1.
AK314476 mRNA. Translation: BAG37081.1.
CH471055 Genomic DNA. Translation: EAW64019.1.
CH471055 Genomic DNA. Translation: EAW64020.1.
CH471055 Genomic DNA. Translation: EAW64016.1.
BC063110 mRNA. Translation: AAH63110.1.
BC137077 mRNA. Translation: AAI37078.1.
BC137078 mRNA. Translation: AAI37079.1.
CCDSiCCDS2589.1. [Q8NFR9-1]
CCDS54552.1. [Q8NFR9-3]
RefSeqiNP_001180309.1. NM_001193380.1. [Q8NFR9-3]
NP_705613.1. NM_153480.1. [Q8NFR9-1]
NP_705614.1. NM_153481.1. [Q8NFR9-2]
NP_705616.2. NM_153483.2.
XP_006713039.1. XM_006712976.1. [Q8NFR9-2]
UniGeneiHs.390823.

Genome annotation databases

EnsembliENST00000383814; ENSP00000373325; ENSG00000163701. [Q8NFR9-1]
ENST00000454190; ENSP00000388086; ENSG00000163701. [Q8NFR9-3]
GeneIDi132014.
KEGGihsa:132014.
UCSCiuc003btw.4. human. [Q8NFR9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF458069 mRNA. Translation: AAM77573.1.
AY358451 mRNA. Translation: AAQ88816.1.
AK074238 mRNA. Translation: BAB85028.1. Frameshift.
AK096793 mRNA. Translation: BAC04863.1.
AK096801 mRNA. Translation: BAC04864.1.
AK314476 mRNA. Translation: BAG37081.1.
CH471055 Genomic DNA. Translation: EAW64019.1.
CH471055 Genomic DNA. Translation: EAW64020.1.
CH471055 Genomic DNA. Translation: EAW64016.1.
BC063110 mRNA. Translation: AAH63110.1.
BC137077 mRNA. Translation: AAI37078.1.
BC137078 mRNA. Translation: AAI37079.1.
CCDSiCCDS2589.1. [Q8NFR9-1]
CCDS54552.1. [Q8NFR9-3]
RefSeqiNP_001180309.1. NM_001193380.1. [Q8NFR9-3]
NP_705613.1. NM_153480.1. [Q8NFR9-1]
NP_705614.1. NM_153481.1. [Q8NFR9-2]
NP_705616.2. NM_153483.2.
XP_006713039.1. XM_006712976.1. [Q8NFR9-2]
UniGeneiHs.390823.

3D structure databases

ProteinModelPortaliQ8NFR9.
SMRiQ8NFR9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126304. 9 interactors.
IntActiQ8NFR9. 1 interactor.
STRINGi9606.ENSP00000295980.

PTM databases

iPTMnetiQ8NFR9.
PhosphoSitePlusiQ8NFR9.

Polymorphism and mutation databases

BioMutaiIL17RE.
DMDMi74730297.

Proteomic databases

PaxDbiQ8NFR9.
PeptideAtlasiQ8NFR9.
PRIDEiQ8NFR9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383814; ENSP00000373325; ENSG00000163701. [Q8NFR9-1]
ENST00000454190; ENSP00000388086; ENSG00000163701. [Q8NFR9-3]
GeneIDi132014.
KEGGihsa:132014.
UCSCiuc003btw.4. human. [Q8NFR9-1]

Organism-specific databases

CTDi132014.
DisGeNETi132014.
GeneCardsiIL17RE.
HGNCiHGNC:18439. IL17RE.
HPAiHPA019011.
MIMi614995. gene.
neXtProtiNX_Q8NFR9.
OpenTargetsiENSG00000163701.
PharmGKBiPA134896136.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFAR. Eukaryota.
ENOG410XTAY. LUCA.
GeneTreeiENSGT00730000111008.
HOVERGENiHBG102913.
InParanoidiQ8NFR9.
KOiK05168.
PhylomeDBiQ8NFR9.
TreeFamiTF335690.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163701-MONOMER.
ReactomeiR-HSA-448424. Interleukin-17 signaling.

Miscellaneous databases

GenomeRNAii132014.
PROiQ8NFR9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163701.
CleanExiHS_IL17RE.
ExpressionAtlasiQ8NFR9. baseline and differential.
GenevisibleiQ8NFR9. HS.

Family and domain databases

InterProiIPR027841. IL-17_rcpt_C/E_N.
IPR013568. SEFIR_dom.
[Graphical view]
PfamiPF15037. IL17_R_N. 1 hit.
PF08357. SEFIR. 2 hits.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI17RE_HUMAN
AccessioniPrimary (citable) accession number: Q8NFR9
Secondary accession number(s): B2RB34
, B2RNR1, B9EH65, Q6P532, Q8N8H7, Q8N8H8, Q8TEC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.