Q8NFR9 (I17RE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-17 receptor E
Short name=IL-17 receptor E
Short name=IL-17RE

Gene names

Name:	IL17RE
ORF Names:	UNQ3056/PRO9877

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	667 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors. Ref.7 Ref.8
Subunit structure	Forms heterodimers with IL17RA; the heterodimer binds IL17C.
Subcellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein By similarity. Isoform 2: Cytoplasm Probable. Isoform 3: Secreted Probable. Isoform 4: Cytoplasm Probable. Isoform 5: Secreted Probable.
Tissue specificity	Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines. Ref.6 Ref.8
Sequence similarities	Contains 1 SEFIR domain.
Sequence caution	Isoform 3: The sequence BAB85028.1 differs from that shown. Reason: Frameshift at position 435.

Ontologies

Keywords
Biological process	Inflammatory response
Cellular component	Cell membrane Cytoplasm Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
IL17RA	Q96F46	2	EBI-5591275,EBI-5591258

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NFR9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NFR9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.

Isoform 3 (identifier: Q8NFR9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     433-533: VWRSDVQFAW...VDLWEGRHVA → LHASLSSPGG...GAAAPGGSAG
     534-667: Missing.

Isoform 4 (identifier: Q8NFR9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     433-506: VWRSDVQFAW...DSEAQRRLVG → ASSWSRHKPT...RMSLTDTWGS
     507-667: Missing.

Isoform 5 (identifier: Q8NFR9-5)

The sequence of this isoform differs from the canonical sequence as follows:
     268-271: YGSD → CECC
     272-667: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 667	644	Interleukin-17 receptor E		PRO_0000309467
Regions
	Topological domain	24 – 454	431	Extracellular Potential
	Transmembrane	455 – 475	21	Helical; Potential
	Topological domain	476 – 667	192	Cytoplasmic Potential
	Domain	487 – 624	138	SEFIR
Amino acid modifications
	Glycosylation	318	1	N-linked (GlcNAc...) Potential
	Glycosylation	347	1	N-linked (GlcNAc...) Potential
	Glycosylation	364	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 116	116	Missing in isoform 2 and isoform 4.		VSP_029190
	Alternative sequence	268 – 271	4	YGSD → CECC in isoform 5.		VSP_029191
	Alternative sequence	272 – 667	396	Missing in isoform 5.		VSP_029192
	Alternative sequence	433 – 533	101	VWRSD…GRHVA → LHASLSSPGGEDAWLIGVGG SVPSGVAVRCPVCLEAPLVS GCLLQTPGALDPGTAGPPHP TGCCSGPHLPAPTVRPGPSA ASAPPARGGLGGAAAPGGSA G in isoform 3.		VSP_029193
	Alternative sequence	433 – 506	74	VWRSD…RRLVG → ASSWSRHKPTWEEFPSQWGL PSPPAPCFTQLPGRRRCLAH RGGGLCALRCGGQMSSLPGS TSCVRMSLTDTWGS in isoform 4.		VSP_029194
	Alternative sequence	507 – 667	161	Missing in isoform 4.		VSP_029195
	Alternative sequence	534 – 667	134	Missing in isoform 3.		VSP_029196
	Natural variant	219	1	Y → C. Corresponds to variant rs7356031 [ dbSNP | Ensembl ].		VAR_036956
	Natural variant	402	1	P → S. Corresponds to variant rs9870003 [ dbSNP | Ensembl ].		VAR_036957
	Natural variant	417	1	S → T. Corresponds to variant rs7647642 [ dbSNP | Ensembl ].		VAR_036958
Experimental info
	Sequence conflict	270	1	S → P in BAC04864. Ref.3
	Sequence conflict	445	1	L → F in BAC04864. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 1493744E7354067D	FASTA	667	74,810
	10 20 30 40 50 60 MGSSRLAALL LPLLLIVIDL SDSAGIGFRH LPHWNTRCPL ASHTDDSFTG SSAYIPCRTW 70 80 90 100 110 120 WALFSTKPWC VRVWHCSRCL CQHLLSGGSG LQRGLFHLLV QKSKKSSTFK FYRRHKMPAP 130 140 150 160 170 180 AQRKLLPRRH LSEKSHHISI PSPDISHKGL RSKRTQPSDP ETWESLPRLD SQRHGGPEFS 190 200 210 220 230 240 FDLLPEARAI RVTISSGPEV SVRLCHQWAL ECEELSSPYD VQKIVSGGHT VELPYEFLLP 250 260 270 280 290 300 CLCIEASYLQ EDTVRRKKCP FQSWPEAYGS DFWKSVHFTD YSQHTQMVMA LTLRCPLKLE 310 320 330 340 350 360 AALCQRHDWH TLCKDLPNAT ARESDGWYVL EKVDLHPQLC FKFSFGNSSH VECPHQTGSL 370 380 390 400 410 420 TSWNVSMDTQ AQQLILHFSS RMHATFSAAW SLPGLGQDTL VPPVYTVSQA RGSSPVSLDL 430 440 450 460 470 480 IIPFLRPGCC VLVWRSDVQF AWKHLLCPDV SYRHLGLLIL ALLALLTLLG VVLALTCRRP 490 500 510 520 530 540 QSGPGPARPV LLLHAADSEA QRRLVGALAE LLRAALGGGR DVIVDLWEGR HVARVGPLPW 550 560 570 580 590 600 LWAARTRVAR EQGTVLLLWS GADLRPVSGP DPRAAPLLAL LHAAPRPLLL LAYFSRLCAK 610 620 630 640 650 660 GDIPPPLRAL PRYRLLRDLP RLLRALDARP FAEATSWGRL GARQRRQSRL ELCSRLEREA ARLADLG
	Isoform 2 [UniParc]. Checksum: 2A2B20E30F565006	FASTA	551	61,658
	10 20 30 40 50 60 MPAPAQRKLL PRRHLSEKSH HISIPSPDIS HKGLRSKRTQ PSDPETWESL PRLDSQRHGG 70 80 90 100 110 120 PEFSFDLLPE ARAIRVTISS GPEVSVRLCH QWALECEELS SPYDVQKIVS GGHTVELPYE 130 140 150 160 170 180 FLLPCLCIEA SYLQEDTVRR KKCPFQSWPE AYGSDFWKSV HFTDYSQHTQ MVMALTLRCP 190 200 210 220 230 240 LKLEAALCQR HDWHTLCKDL PNATARESDG WYVLEKVDLH PQLCFKFSFG NSSHVECPHQ 250 260 270 280 290 300 TGSLTSWNVS MDTQAQQLIL HFSSRMHATF SAAWSLPGLG QDTLVPPVYT VSQARGSSPV 310 320 330 340 350 360 SLDLIIPFLR PGCCVLVWRS DVQFAWKHLL CPDVSYRHLG LLILALLALL TLLGVVLALT 370 380 390 400 410 420 CRRPQSGPGP ARPVLLLHAA DSEAQRRLVG ALAELLRAAL GGGRDVIVDL WEGRHVARVG 430 440 450 460 470 480 PLPWLWAART RVAREQGTVL LLWSGADLRP VSGPDPRAAP LLALLHAAPR PLLLLAYFSR 490 500 510 520 530 540 LCAKGDIPPP LRALPRYRLL RDLPRLLRAL DARPFAEATS WGRLGARQRR QSRLELCSRL 550 EREAARLADL G
	Isoform 3 [UniParc]. Checksum: 50C7F4E844688570	FASTA	533	58,121
	10 20 30 40 50 60 MGSSRLAALL LPLLLIVIDL SDSAGIGFRH LPHWNTRCPL ASHTDDSFTG SSAYIPCRTW 70 80 90 100 110 120 WALFSTKPWC VRVWHCSRCL CQHLLSGGSG LQRGLFHLLV QKSKKSSTFK FYRRHKMPAP 130 140 150 160 170 180 AQRKLLPRRH LSEKSHHISI PSPDISHKGL RSKRTQPSDP ETWESLPRLD SQRHGGPEFS 190 200 210 220 230 240 FDLLPEARAI RVTISSGPEV SVRLCHQWAL ECEELSSPYD VQKIVSGGHT VELPYEFLLP 250 260 270 280 290 300 CLCIEASYLQ EDTVRRKKCP FQSWPEAYGS DFWKSVHFTD YSQHTQMVMA LTLRCPLKLE 310 320 330 340 350 360 AALCQRHDWH TLCKDLPNAT ARESDGWYVL EKVDLHPQLC FKFSFGNSSH VECPHQTGSL 370 380 390 400 410 420 TSWNVSMDTQ AQQLILHFSS RMHATFSAAW SLPGLGQDTL VPPVYTVSQA RGSSPVSLDL 430 440 450 460 470 480 IIPFLRPGCC VLLHASLSSP GGEDAWLIGV GGSVPSGVAV RCPVCLEAPL VSGCLLQTPG 490 500 510 520 530 ALDPGTAGPP HPTGCCSGPH LPAPTVRPGP SAASAPPARG GLGGAAAPGG SAG
	Isoform 4 [UniParc]. Checksum: 31D49E817A1FC686	FASTA	390	43,699
	10 20 30 40 50 60 MPAPAQRKLL PRRHLSEKSH HISIPSPDIS HKGLRSKRTQ PSDPETWESL PRLDSQRHGG 70 80 90 100 110 120 PEFSFDLLPE ARAIRVTISS GPEVSVRLCH QWALECEELS SPYDVQKIVS GGHTVELPYE 130 140 150 160 170 180 FLLPCLCIEA SYLQEDTVRR KKCPFQSWPE AYGSDFWKSV HFTDYSQHTQ MVMALTLRCP 190 200 210 220 230 240 LKLEAALCQR HDWHTLCKDL PNATARESDG WYVLEKVDLH PQLCFKFSFG NSSHVECPHQ 250 260 270 280 290 300 TGSLTSWNVS MDTQAQQLIL HFSSRMHATF SAAWSLPGLG QDTLVPPVYT VSQARGSSPV 310 320 330 340 350 360 SLDLIIPFLR PGCCVLASSW SRHKPTWEEF PSQWGLPSPP APCFTQLPGR RRCLAHRGGG 370 380 390 LCALRCGGQM SSLPGSTSCV RMSLTDTWGS
	Isoform 5 [UniParc]. Checksum: 160836A0A928DBC8	FASTA	271	30,781
	10 20 30 40 50 60 MGSSRLAALL LPLLLIVIDL SDSAGIGFRH LPHWNTRCPL ASHTDDSFTG SSAYIPCRTW 70 80 90 100 110 120 WALFSTKPWC VRVWHCSRCL CQHLLSGGSG LQRGLFHLLV QKSKKSSTFK FYRRHKMPAP 130 140 150 160 170 180 AQRKLLPRRH LSEKSHHISI PSPDISHKGL RSKRTQPSDP ETWESLPRLD SQRHGGPEFS 190 200 210 220 230 240 FDLLPEARAI RVTISSGPEV SVRLCHQWAL ECEELSSPYD VQKIVSGGHT VELPYEFLLP 250 260 270 CLCIEASYLQ EDTVRRKKCP FQSWPEACEC C

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of novel IL-17 related receptors." Gilbert J.M., Gorman D.M. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4). Tissue: Colon mucosa, Prostate and Small intestine.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5). Tissue: Lung, Skin and Testis.
[6]	"Identification and functional characterization of a novel interleukin 17 receptor: a possible mitogenic activation through ras/mitogen-activated protein kinase signaling pathway." Li T.-S., Li X.-N., Chang Z.-J., Fu X.-Y., Liu L. Cell. Signal. 18:1287-1298(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[7]	"IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens." Song X., Zhu S., Shi P., Liu Y., Shi Y., Levin S.D., Qian Y. Nat. Immunol. 12:1151-1158(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, IDENTIFICATION AS IL17C RECEPTOR.
[8]	"IL-17C regulates the innate immune function of epithelial cells in an autocrine manner." Ramirez-Carrozzi V., Sambandam A., Luis E., Lin Z., Jeet S., Lesch J., Hackney J., Kim J., Zhou M., Lai J., Modrusan Z., Sai T., Lee W., Xu M., Caplazi P., Diehl L., de Voss J., Balazs M. , Gonzalez L. Jr., Singh H., Ouyang W., Pappu R. Nat. Immunol. 12:1159-1166(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, IDENTIFICATION AS IL17C RECEPTOR, INTERACTION WITH IL17RA, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF458069 mRNA. Translation: AAM77573.1. AY358451 mRNA. Translation: AAQ88816.1. AK074238 mRNA. Translation: BAB85028.1. Frameshift. AK096793 mRNA. Translation: BAC04863.1. AK096801 mRNA. Translation: BAC04864.1. AK314476 mRNA. Translation: BAG37081.1. CH471055 Genomic DNA. Translation: EAW64019.1. CH471055 Genomic DNA. Translation: EAW64020.1. CH471055 Genomic DNA. Translation: EAW64016.1. BC063110 mRNA. Translation: AAH63110.1. BC137077 mRNA. Translation: AAI37078.1. BC137078 mRNA. Translation: AAI37079.1.
IPI	IPI00168887. IPI00177866. IPI00789075. IPI00876915. IPI00971039.
RefSeq	NP_001180309.1. NM_001193380.1. NP_705613.1. NM_153480.1. NP_705616.2. NM_153483.2.
UniGene	Hs.390823.
3D structure databases
ProteinModelPortal	Q8NFR9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NFR9. 1 interaction.
STRING	9606.ENSP00000295980.
PTM databases
PhosphoSite	Q8NFR9.
Polymorphism databases
DMDM	74730297.
Proteomic databases
PaxDb	Q8NFR9.
PRIDE	Q8NFR9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295980; ENSP00000295980; ENSG00000163701. ENST00000383814; ENSP00000373325; ENSG00000163701. ENST00000454190; ENSP00000388086; ENSG00000163701.
GeneID	132014.
KEGG	hsa:132014.
UCSC	uc003btu.3. human. uc003btv.3. human. uc010hcq.3. human.
Organism-specific databases
CTD	132014.
GeneCards	GC03P009944.
HGNC	HGNC:18439. IL17RE.
HPA	HPA019011.
MIM	614995. gene.
neXtProt	NX_Q8NFR9.
PharmGKB	PA134896136.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47803.
HOVERGEN	HBG102913.
InParanoid	Q8NFR9.
KO	K05168.
OrthoDB	EOG4640BK.
PhylomeDB	Q8NFR9.
Gene expression databases
ArrayExpress	Q8NFR9.
Bgee	Q8NFR9.
CleanEx	HS_IL17RE.
Genevestigator	Q8NFR9.
Family and domain databases
InterPro	IPR013568. SEFIR. [Graphical view]
Pfam	PF08357. SEFIR. 2 hits. [Graphical view]
PROSITE	PS51534. SEFIR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	132014.
NextBio	83006.
SOURCE	Search...

Entry information

Entry name

I17RE_HUMAN

Accession

Primary (citable) accession number: Q8NFR9
Secondary accession number(s): B2RB34 , B2RNR1, B9EH65, Q6P532, Q8N8H7, Q8N8H8, Q8TEC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.