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Q8NFR9 (I17RE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-17 receptor E

Short name=IL-17 receptor E
Short name=IL-17RE
Gene names
Name:IL17RE
ORF Names:UNQ3056/PRO9877
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length667 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors. Ref.7 Ref.8

Subunit structure

Forms heterodimers with IL17RA; the heterodimer binds IL17C.

Subcellular location

Isoform 1: Cell membrane; Single-pass type I membrane protein By similarity.

Isoform 2: Cytoplasm Probable.

Isoform 3: Secreted Probable.

Isoform 4: Cytoplasm Probable.

Isoform 5: Secreted Probable.

Tissue specificity

Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines. Ref.6 Ref.8

Sequence similarities

Contains 1 SEFIR domain.

Sequence caution

Isoform 3: The sequence BAB85028.1 differs from that shown. Reason: Frameshift at position 435.

Ontologies

Keywords
   Biological processInflammatory response
   Cellular componentCell membrane
Cytoplasm
Membrane
Secreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processinflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

IL17RAQ96F462EBI-5591275,EBI-5591258

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8NFR9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8NFR9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
Isoform 3 (identifier: Q8NFR9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     433-533: VWRSDVQFAW...VDLWEGRHVA → LHASLSSPGG...GAAAPGGSAG
     534-667: Missing.
Isoform 4 (identifier: Q8NFR9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     433-506: VWRSDVQFAW...DSEAQRRLVG → ASSWSRHKPT...RMSLTDTWGS
     507-667: Missing.
Isoform 5 (identifier: Q8NFR9-5)

The sequence of this isoform differs from the canonical sequence as follows:
     268-271: YGSD → CECC
     272-667: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 667644Interleukin-17 receptor E
PRO_0000309467

Regions

Topological domain24 – 454431Extracellular Potential
Transmembrane455 – 47521Helical; Potential
Topological domain476 – 667192Cytoplasmic Potential
Domain487 – 624138SEFIR

Amino acid modifications

Glycosylation3181N-linked (GlcNAc...) Potential
Glycosylation3471N-linked (GlcNAc...) Potential
Glycosylation3641N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 116116Missing in isoform 2 and isoform 4.
VSP_029190
Alternative sequence268 – 2714YGSD → CECC in isoform 5.
VSP_029191
Alternative sequence272 – 667396Missing in isoform 5.
VSP_029192
Alternative sequence433 – 533101VWRSD…GRHVA → LHASLSSPGGEDAWLIGVGG SVPSGVAVRCPVCLEAPLVS GCLLQTPGALDPGTAGPPHP TGCCSGPHLPAPTVRPGPSA ASAPPARGGLGGAAAPGGSA G in isoform 3.
VSP_029193
Alternative sequence433 – 50674VWRSD…RRLVG → ASSWSRHKPTWEEFPSQWGL PSPPAPCFTQLPGRRRCLAH RGGGLCALRCGGQMSSLPGS TSCVRMSLTDTWGS in isoform 4.
VSP_029194
Alternative sequence507 – 667161Missing in isoform 4.
VSP_029195
Alternative sequence534 – 667134Missing in isoform 3.
VSP_029196
Natural variant2191Y → C.
Corresponds to variant rs7356031 [ dbSNP | Ensembl ].
VAR_036956
Natural variant4021P → S.
Corresponds to variant rs9870003 [ dbSNP | Ensembl ].
VAR_036957
Natural variant4171S → T.
Corresponds to variant rs7647642 [ dbSNP | Ensembl ].
VAR_036958

Experimental info

Sequence conflict2701S → P in BAC04864. Ref.3
Sequence conflict4451L → F in BAC04864. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 1493744E7354067D

FASTA66774,810
        10         20         30         40         50         60 
MGSSRLAALL LPLLLIVIDL SDSAGIGFRH LPHWNTRCPL ASHTDDSFTG SSAYIPCRTW 

        70         80         90        100        110        120 
WALFSTKPWC VRVWHCSRCL CQHLLSGGSG LQRGLFHLLV QKSKKSSTFK FYRRHKMPAP 

       130        140        150        160        170        180 
AQRKLLPRRH LSEKSHHISI PSPDISHKGL RSKRTQPSDP ETWESLPRLD SQRHGGPEFS 

       190        200        210        220        230        240 
FDLLPEARAI RVTISSGPEV SVRLCHQWAL ECEELSSPYD VQKIVSGGHT VELPYEFLLP 

       250        260        270        280        290        300 
CLCIEASYLQ EDTVRRKKCP FQSWPEAYGS DFWKSVHFTD YSQHTQMVMA LTLRCPLKLE 

       310        320        330        340        350        360 
AALCQRHDWH TLCKDLPNAT ARESDGWYVL EKVDLHPQLC FKFSFGNSSH VECPHQTGSL 

       370        380        390        400        410        420 
TSWNVSMDTQ AQQLILHFSS RMHATFSAAW SLPGLGQDTL VPPVYTVSQA RGSSPVSLDL 

       430        440        450        460        470        480 
IIPFLRPGCC VLVWRSDVQF AWKHLLCPDV SYRHLGLLIL ALLALLTLLG VVLALTCRRP 

       490        500        510        520        530        540 
QSGPGPARPV LLLHAADSEA QRRLVGALAE LLRAALGGGR DVIVDLWEGR HVARVGPLPW 

       550        560        570        580        590        600 
LWAARTRVAR EQGTVLLLWS GADLRPVSGP DPRAAPLLAL LHAAPRPLLL LAYFSRLCAK 

       610        620        630        640        650        660 
GDIPPPLRAL PRYRLLRDLP RLLRALDARP FAEATSWGRL GARQRRQSRL ELCSRLEREA 


ARLADLG 

« Hide

Isoform 2 [UniParc].

Checksum: 2A2B20E30F565006
Show »

FASTA55161,658
Isoform 3 [UniParc].

Checksum: 50C7F4E844688570
Show »

FASTA53358,121
Isoform 4 [UniParc].

Checksum: 31D49E817A1FC686
Show »

FASTA39043,699
Isoform 5 [UniParc].

Checksum: 160836A0A928DBC8
Show »

FASTA27130,781

References

« Hide 'large scale' references
[1]"Identification of novel IL-17 related receptors."
Gilbert J.M., Gorman D.M.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
Tissue: Colon mucosa, Prostate and Small intestine.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
Tissue: Lung, Skin and Testis.
[6]"Identification and functional characterization of a novel interleukin 17 receptor: a possible mitogenic activation through ras/mitogen-activated protein kinase signaling pathway."
Li T.-S., Li X.-N., Chang Z.-J., Fu X.-Y., Liu L.
Cell. Signal. 18:1287-1298(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[7]"IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens."
Song X., Zhu S., Shi P., Liu Y., Shi Y., Levin S.D., Qian Y.
Nat. Immunol. 12:1151-1158(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION AS IL17C RECEPTOR.
[8]"IL-17C regulates the innate immune function of epithelial cells in an autocrine manner."
Ramirez-Carrozzi V., Sambandam A., Luis E., Lin Z., Jeet S., Lesch J., Hackney J., Kim J., Zhou M., Lai J., Modrusan Z., Sai T., Lee W., Xu M., Caplazi P., Diehl L., de Voss J., Balazs M. expand/collapse author list , Gonzalez L. Jr., Singh H., Ouyang W., Pappu R.
Nat. Immunol. 12:1159-1166(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION AS IL17C RECEPTOR, INTERACTION WITH IL17RA, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF458069 mRNA. Translation: AAM77573.1.
AY358451 mRNA. Translation: AAQ88816.1.
AK074238 mRNA. Translation: BAB85028.1. Frameshift.
AK096793 mRNA. Translation: BAC04863.1.
AK096801 mRNA. Translation: BAC04864.1.
AK314476 mRNA. Translation: BAG37081.1.
CH471055 Genomic DNA. Translation: EAW64019.1.
CH471055 Genomic DNA. Translation: EAW64020.1.
CH471055 Genomic DNA. Translation: EAW64016.1.
BC063110 mRNA. Translation: AAH63110.1.
BC137077 mRNA. Translation: AAI37078.1.
BC137078 mRNA. Translation: AAI37079.1.
RefSeqNP_001180309.1. NM_001193380.1.
NP_705613.1. NM_153480.1.
NP_705614.1. NM_153481.1.
NP_705616.2. NM_153483.2.
UniGeneHs.390823.

3D structure databases

ProteinModelPortalQ8NFR9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8NFR9. 1 interaction.
STRING9606.ENSP00000295980.

PTM databases

PhosphoSiteQ8NFR9.

Polymorphism databases

DMDM74730297.

Proteomic databases

PaxDbQ8NFR9.
PRIDEQ8NFR9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295980; ENSP00000295980; ENSG00000163701. [Q8NFR9-1]
ENST00000383814; ENSP00000373325; ENSG00000163701. [Q8NFR9-1]
ENST00000454190; ENSP00000388086; ENSG00000163701. [Q8NFR9-3]
GeneID132014.
KEGGhsa:132014.
UCSCuc003btv.3. human. [Q8NFR9-5]
uc003btw.3. human. [Q8NFR9-1]
uc010hcq.3. human. [Q8NFR9-3]

Organism-specific databases

CTD132014.
GeneCardsGC03P009944.
HGNCHGNC:18439. IL17RE.
HPAHPA019011.
MIM614995. gene.
neXtProtNX_Q8NFR9.
PharmGKBPA134896136.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47803.
HOVERGENHBG102913.
InParanoidQ8NFR9.
KOK05168.
PhylomeDBQ8NFR9.
TreeFamTF335690.

Gene expression databases

ArrayExpressQ8NFR9.
BgeeQ8NFR9.
CleanExHS_IL17RE.
GenevestigatorQ8NFR9.

Family and domain databases

InterProIPR027841. IL-17_rcpt_C/E_N.
IPR013568. SEFIR.
[Graphical view]
PfamPF15037. IL17_R_N. 1 hit.
PF08357. SEFIR. 2 hits.
[Graphical view]
PROSITEPS51534. SEFIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi132014.
NextBio83006.
PROQ8NFR9.
SOURCESearch...

Entry information

Entry nameI17RE_HUMAN
AccessionPrimary (citable) accession number: Q8NFR9
Secondary accession number(s): B2RB34 expand/collapse secondary AC list , B2RNR1, B9EH65, Q6P532, Q8N8H7, Q8N8H8, Q8TEC2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2002
Last modified: March 19, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM