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Q8NFR9

- I17RE_HUMAN

UniProt

Q8NFR9 - I17RE_HUMAN

Protein

Interleukin-17 receptor E

Gene

IL17RE

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-17 receptor E
    Short name:
    IL-17 receptor E
    Short name:
    IL-17RE
    Gene namesi
    Name:IL17RE
    ORF Names:UNQ3056/PRO9877
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:18439. IL17RE.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134896136.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 667644Interleukin-17 receptor EPRO_0000309467Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi364 – 3641N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8NFR9.
    PRIDEiQ8NFR9.

    PTM databases

    PhosphoSiteiQ8NFR9.

    Expressioni

    Tissue specificityi

    Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines.2 Publications

    Gene expression databases

    ArrayExpressiQ8NFR9.
    BgeeiQ8NFR9.
    CleanExiHS_IL17RE.
    GenevestigatoriQ8NFR9.

    Organism-specific databases

    HPAiHPA019011.

    Interactioni

    Subunit structurei

    Forms heterodimers with IL17RA; the heterodimer binds IL17C.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    IL17RAQ96F462EBI-5591275,EBI-5591258

    Protein-protein interaction databases

    IntActiQ8NFR9. 1 interaction.
    STRINGi9606.ENSP00000295980.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NFR9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 454431ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini476 – 667192CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei455 – 47521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini487 – 624138SEFIRPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SEFIR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47803.
    HOVERGENiHBG102913.
    InParanoidiQ8NFR9.
    KOiK05168.
    PhylomeDBiQ8NFR9.
    TreeFamiTF335690.

    Family and domain databases

    InterProiIPR027841. IL-17_rcpt_C/E_N.
    IPR013568. SEFIR.
    [Graphical view]
    PfamiPF15037. IL17_R_N. 1 hit.
    PF08357. SEFIR. 2 hits.
    [Graphical view]
    PROSITEiPS51534. SEFIR. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NFR9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGSSRLAALL LPLLLIVIDL SDSAGIGFRH LPHWNTRCPL ASHTDDSFTG    50
    SSAYIPCRTW WALFSTKPWC VRVWHCSRCL CQHLLSGGSG LQRGLFHLLV 100
    QKSKKSSTFK FYRRHKMPAP AQRKLLPRRH LSEKSHHISI PSPDISHKGL 150
    RSKRTQPSDP ETWESLPRLD SQRHGGPEFS FDLLPEARAI RVTISSGPEV 200
    SVRLCHQWAL ECEELSSPYD VQKIVSGGHT VELPYEFLLP CLCIEASYLQ 250
    EDTVRRKKCP FQSWPEAYGS DFWKSVHFTD YSQHTQMVMA LTLRCPLKLE 300
    AALCQRHDWH TLCKDLPNAT ARESDGWYVL EKVDLHPQLC FKFSFGNSSH 350
    VECPHQTGSL TSWNVSMDTQ AQQLILHFSS RMHATFSAAW SLPGLGQDTL 400
    VPPVYTVSQA RGSSPVSLDL IIPFLRPGCC VLVWRSDVQF AWKHLLCPDV 450
    SYRHLGLLIL ALLALLTLLG VVLALTCRRP QSGPGPARPV LLLHAADSEA 500
    QRRLVGALAE LLRAALGGGR DVIVDLWEGR HVARVGPLPW LWAARTRVAR 550
    EQGTVLLLWS GADLRPVSGP DPRAAPLLAL LHAAPRPLLL LAYFSRLCAK 600
    GDIPPPLRAL PRYRLLRDLP RLLRALDARP FAEATSWGRL GARQRRQSRL 650
    ELCSRLEREA ARLADLG 667
    Length:667
    Mass (Da):74,810
    Last modified:October 1, 2002 - v1
    Checksum:i1493744E7354067D
    GO
    Isoform 2 (identifier: Q8NFR9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-116: Missing.

    Show »
    Length:551
    Mass (Da):61,658
    Checksum:i2A2B20E30F565006
    GO
    Isoform 3 (identifier: Q8NFR9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         433-533: VWRSDVQFAW...VDLWEGRHVA → LHASLSSPGG...GAAAPGGSAG
         534-667: Missing.

    Show »
    Length:533
    Mass (Da):58,121
    Checksum:i50C7F4E844688570
    GO
    Isoform 4 (identifier: Q8NFR9-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-116: Missing.
         433-506: VWRSDVQFAW...DSEAQRRLVG → ASSWSRHKPT...RMSLTDTWGS
         507-667: Missing.

    Show »
    Length:390
    Mass (Da):43,699
    Checksum:i31D49E817A1FC686
    GO
    Isoform 5 (identifier: Q8NFR9-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         268-271: YGSD → CECC
         272-667: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:271
    Mass (Da):30,781
    Checksum:i160836A0A928DBC8
    GO

    Sequence cautioni

    Isoform 3 : The sequence BAB85028.1 differs from that shown. Reason: Frameshift at position 435.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti270 – 2701S → P in BAC04864. (PubMed:14702039)Curated
    Sequence conflicti445 – 4451L → F in BAC04864. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti219 – 2191Y → C.
    Corresponds to variant rs7356031 [ dbSNP | Ensembl ].
    VAR_036956
    Natural varianti402 – 4021P → S.
    Corresponds to variant rs9870003 [ dbSNP | Ensembl ].
    VAR_036957
    Natural varianti417 – 4171S → T.
    Corresponds to variant rs7647642 [ dbSNP | Ensembl ].
    VAR_036958

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 116116Missing in isoform 2 and isoform 4. 1 PublicationVSP_029190Add
    BLAST
    Alternative sequencei268 – 2714YGSD → CECC in isoform 5. 1 PublicationVSP_029191
    Alternative sequencei272 – 667396Missing in isoform 5. 1 PublicationVSP_029192Add
    BLAST
    Alternative sequencei433 – 533101VWRSD…GRHVA → LHASLSSPGGEDAWLIGVGG SVPSGVAVRCPVCLEAPLVS GCLLQTPGALDPGTAGPPHP TGCCSGPHLPAPTVRPGPSA ASAPPARGGLGGAAAPGGSA G in isoform 3. 1 PublicationVSP_029193Add
    BLAST
    Alternative sequencei433 – 50674VWRSD…RRLVG → ASSWSRHKPTWEEFPSQWGL PSPPAPCFTQLPGRRRCLAH RGGGLCALRCGGQMSSLPGS TSCVRMSLTDTWGS in isoform 4. 1 PublicationVSP_029194Add
    BLAST
    Alternative sequencei507 – 667161Missing in isoform 4. 1 PublicationVSP_029195Add
    BLAST
    Alternative sequencei534 – 667134Missing in isoform 3. 1 PublicationVSP_029196Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF458069 mRNA. Translation: AAM77573.1.
    AY358451 mRNA. Translation: AAQ88816.1.
    AK074238 mRNA. Translation: BAB85028.1. Frameshift.
    AK096793 mRNA. Translation: BAC04863.1.
    AK096801 mRNA. Translation: BAC04864.1.
    AK314476 mRNA. Translation: BAG37081.1.
    CH471055 Genomic DNA. Translation: EAW64019.1.
    CH471055 Genomic DNA. Translation: EAW64020.1.
    CH471055 Genomic DNA. Translation: EAW64016.1.
    BC063110 mRNA. Translation: AAH63110.1.
    BC137077 mRNA. Translation: AAI37078.1.
    BC137078 mRNA. Translation: AAI37079.1.
    CCDSiCCDS2589.1. [Q8NFR9-1]
    CCDS54552.1. [Q8NFR9-3]
    RefSeqiNP_001180309.1. NM_001193380.1. [Q8NFR9-3]
    NP_705613.1. NM_153480.1. [Q8NFR9-1]
    NP_705614.1. NM_153481.1. [Q8NFR9-2]
    NP_705616.2. NM_153483.2.
    XP_006713039.1. XM_006712976.1. [Q8NFR9-2]
    UniGeneiHs.390823.

    Genome annotation databases

    EnsembliENST00000383814; ENSP00000373325; ENSG00000163701. [Q8NFR9-1]
    ENST00000454190; ENSP00000388086; ENSG00000163701. [Q8NFR9-3]
    GeneIDi132014.
    KEGGihsa:132014.
    UCSCiuc003btv.3. human. [Q8NFR9-5]
    uc003btw.3. human. [Q8NFR9-1]
    uc010hcq.3. human. [Q8NFR9-3]

    Polymorphism databases

    DMDMi74730297.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF458069 mRNA. Translation: AAM77573.1 .
    AY358451 mRNA. Translation: AAQ88816.1 .
    AK074238 mRNA. Translation: BAB85028.1 . Frameshift.
    AK096793 mRNA. Translation: BAC04863.1 .
    AK096801 mRNA. Translation: BAC04864.1 .
    AK314476 mRNA. Translation: BAG37081.1 .
    CH471055 Genomic DNA. Translation: EAW64019.1 .
    CH471055 Genomic DNA. Translation: EAW64020.1 .
    CH471055 Genomic DNA. Translation: EAW64016.1 .
    BC063110 mRNA. Translation: AAH63110.1 .
    BC137077 mRNA. Translation: AAI37078.1 .
    BC137078 mRNA. Translation: AAI37079.1 .
    CCDSi CCDS2589.1. [Q8NFR9-1 ]
    CCDS54552.1. [Q8NFR9-3 ]
    RefSeqi NP_001180309.1. NM_001193380.1. [Q8NFR9-3 ]
    NP_705613.1. NM_153480.1. [Q8NFR9-1 ]
    NP_705614.1. NM_153481.1. [Q8NFR9-2 ]
    NP_705616.2. NM_153483.2.
    XP_006713039.1. XM_006712976.1. [Q8NFR9-2 ]
    UniGenei Hs.390823.

    3D structure databases

    ProteinModelPortali Q8NFR9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8NFR9. 1 interaction.
    STRINGi 9606.ENSP00000295980.

    PTM databases

    PhosphoSitei Q8NFR9.

    Polymorphism databases

    DMDMi 74730297.

    Proteomic databases

    PaxDbi Q8NFR9.
    PRIDEi Q8NFR9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000383814 ; ENSP00000373325 ; ENSG00000163701 . [Q8NFR9-1 ]
    ENST00000454190 ; ENSP00000388086 ; ENSG00000163701 . [Q8NFR9-3 ]
    GeneIDi 132014.
    KEGGi hsa:132014.
    UCSCi uc003btv.3. human. [Q8NFR9-5 ]
    uc003btw.3. human. [Q8NFR9-1 ]
    uc010hcq.3. human. [Q8NFR9-3 ]

    Organism-specific databases

    CTDi 132014.
    GeneCardsi GC03P009944.
    HGNCi HGNC:18439. IL17RE.
    HPAi HPA019011.
    MIMi 614995. gene.
    neXtProti NX_Q8NFR9.
    PharmGKBi PA134896136.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47803.
    HOVERGENi HBG102913.
    InParanoidi Q8NFR9.
    KOi K05168.
    PhylomeDBi Q8NFR9.
    TreeFami TF335690.

    Miscellaneous databases

    GenomeRNAii 132014.
    NextBioi 83006.
    PROi Q8NFR9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NFR9.
    Bgeei Q8NFR9.
    CleanExi HS_IL17RE.
    Genevestigatori Q8NFR9.

    Family and domain databases

    InterProi IPR027841. IL-17_rcpt_C/E_N.
    IPR013568. SEFIR.
    [Graphical view ]
    Pfami PF15037. IL17_R_N. 1 hit.
    PF08357. SEFIR. 2 hits.
    [Graphical view ]
    PROSITEi PS51534. SEFIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel IL-17 related receptors."
      Gilbert J.M., Gorman D.M.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
      Tissue: Colon mucosa, Prostate and Small intestine.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
      Tissue: Lung, Skin and Testis.
    6. "Identification and functional characterization of a novel interleukin 17 receptor: a possible mitogenic activation through ras/mitogen-activated protein kinase signaling pathway."
      Li T.-S., Li X.-N., Chang Z.-J., Fu X.-Y., Liu L.
      Cell. Signal. 18:1287-1298(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. "IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens."
      Song X., Zhu S., Shi P., Liu Y., Shi Y., Levin S.D., Qian Y.
      Nat. Immunol. 12:1151-1158(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION AS IL17C RECEPTOR.
    8. Cited for: FUNCTION, IDENTIFICATION AS IL17C RECEPTOR, INTERACTION WITH IL17RA, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiI17RE_HUMAN
    AccessioniPrimary (citable) accession number: Q8NFR9
    Secondary accession number(s): B2RB34
    , B2RNR1, B9EH65, Q6P532, Q8N8H7, Q8N8H8, Q8TEC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3