Q8NFQ8 (TOIP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Torsin-1A-interacting protein 2

Alternative name(s):
Lumenal domain-like LAP1

Gene names

Name:	TOR1AIP2
Synonyms:	LULL1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with TOR1A. Ref.4
Subcellular location	Endoplasmic reticulum membrane; Single-pass membrane protein Ref.4.
Sequence similarities	Belongs to the TOR1AIP family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
PTM	Acetylation Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TOR1A	O14656	1	EBI-524567,EBI-524257

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 470	469	Torsin-1A-interacting protein 2		PRO_0000228838
Regions
	Transmembrane	215 – 235	21	Helical; Potential
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.6
	Modified residue	120	1	Phosphoserine Ref.5
	Modified residue	163	1	Phosphoserine Ref.5
	Glycosylation	289	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8NFQ8 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 275CB5E28B7D4338	FASTA	470	51,263
	10 20 30 40 50 60 MADSGLREPQ EDSQKDLEND PSVNSQAQET TIIASNAEEA EILHSACGLS KDHQEVETEG 70 80 90 100 110 120 PESADTGDKS ESPDEANVGK HPKDKTEDEN KQSFLDGGKG HHLPSENLGK EPLDPDPSHS 130 140 150 160 170 180 PSDKVGRADA HLGSSSVALP KEASDGTGAS QEPPTTDSQE AQSPGHSSAG QEGEDTLRRR 190 200 210 220 230 240 LLAPEAGSHP QQTQKLEEIK ENAQDTMRQI NKKGFWSYGP VILVVLVVAV VASSVNSYYS 250 260 270 280 290 300 SPAQQVPKNP ALEAFLAQFS QLEDKFPGQS SFLWQRGRKF LQKHLNASNP TEPATIIFTA 310 320 330 340 350 360 AREGRETLKC LSHHVADAYT SSQKVSPIQI DGAGRTWQDS DTVKLLVDLE LSYGFENGQK 370 380 390 400 410 420 AAVVHHFESF PAGSTLIFYK YCDHENAAFK DVALVLTVLL EEETLEASVG PRETEEKVRD 430 440 450 460 470 LLWAKFTNSD TPTSFNHMDS DKLSGLWSRI SHLVLPVQPV SSIEEQGCLF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Guo J.H., Yu L. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"The AAA+ protein torsinA interacts with a conserved domain present in LAP1 and a novel ER protein." Goodchild R.E., Dauer W.T. J. Cell Biol. 168:855-862(2005) [PubMed: 15767459] [Abstract] Cited for: INTERACTION WITH TORSIN-A, SUBCELLULAR LOCATION.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120 AND SER-163, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY. Tissue: Embryonic kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF464140 mRNA. Translation: AAM50514.1. AL359853 Genomic DNA. Translation: CAH70382.1. BC101532 mRNA. Translation: AAI01533.1. BC112225 mRNA. Translation: AAI12226.1.
IPI	IPI00168878.
RefSeq	NP_001186189.1. NM_001199260.1. NP_659471.1. NM_145034.4.
UniGene	Hs.571797. Hs.723247.
3D structure databases
ProteinModelPortal	Q8NFQ8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NFQ8. 1 interaction.
STRING	Q8NFQ8.
PTM databases
PhosphoSite	Q8NFQ8.
Polymorphism databases
DMDM	74751288.
Proteomic databases
PeptideAtlas	Q8NFQ8.
PRIDE	Q8NFQ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000367612; ENSP00000356584; ENSG00000169905. ENST00000419174; ENSP00000410193; ENSG00000169905.
GeneID	163590.
KEGG	hsa:163590.
UCSC	uc001gnk.1. human.
Organism-specific databases
CTD	163590.
GeneCards	GC01M179809.
H-InvDB	HIX0001381.
HGNC	HGNC:24055. TOR1AIP2.
neXtProt	NX_Q8NFQ8.
PharmGKB	PA142670716.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06573.
GeneTree	ENSGT00390000012166.
HOGENOM	HBG125848.
HOVERGEN	HBG094081.
InParanoid	Q8NFQ8.
OMA	QKDLEND.
OrthoDB	EOG4Q2DFJ.
PhylomeDB	Q8NFQ8.
Gene expression databases
ArrayExpress	Q8NFQ8.
Bgee	Q8NFQ8.
CleanEx	HS_TOR1AIP2.
Genevestigator	Q8NFQ8.
GermOnline	ENSG00000169905. Homo sapiens.
Family and domain databases
InterPro	IPR008662. Lamina-ass_polypeptide_CLAP1C. [Graphical view]
Pfam	PF05609. LAP1C. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	88372.

Entry information

Entry name

TOIP2_HUMAN

Accession

Primary (citable) accession number: Q8NFQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.