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Protein

Torsin-1A-interacting protein 2

Gene

TOR1AIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity.3 Publications

GO - Molecular functioni

  • ATPase activator activity Source: UniProtKB
  • ATPase binding Source: UniProtKB

GO - Biological processi

  • endoplasmic reticulum organization Source: UniProtKB
  • positive regulation of ATPase activity Source: UniProtKB
  • protein localization to nuclear envelope Source: CACAO
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169905-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Torsin-1A-interacting protein 2
Alternative name(s):
Lumenal domain-like LAP1
Gene namesi
Name:TOR1AIP2
Synonyms:IFRG15, LULL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24055. TOR1AIP2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 214CytoplasmicSequence analysisAdd BLAST213
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Topological domaini236 – 470LumenalSequence analysisAdd BLAST235

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi163590.
OpenTargetsiENSG00000169905.
PharmGKBiPA142670716.

Polymorphism and mutation databases

BioMutaiTOR1AIP2.
DMDMi74751288.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002288382 – 470Torsin-1A-interacting protein 2Add BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei13PhosphoserineCombined sources1
Modified residuei93PhosphoserineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei163PhosphoserineCombined sources1
Modified residuei176PhosphothreonineCombined sources1
Modified residuei193PhosphothreonineCombined sources1
Glycosylationi289N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8NFQ8.
PaxDbiQ8NFQ8.
PeptideAtlasiQ8NFQ8.
PRIDEiQ8NFQ8.

PTM databases

iPTMnetiQ8NFQ8.
PhosphoSitePlusiQ8NFQ8.
SwissPalmiQ8NFQ8.

Expressioni

Gene expression databases

BgeeiENSG00000169905.
CleanExiHS_TOR1AIP2.
ExpressionAtlasiQ8NFQ8. baseline and differential.
GenevisibleiQ8NFQ8. HS.

Organism-specific databases

HPAiHPA051849.
HPA070542.

Interactioni

Subunit structurei

Interacts with TOR1A and TOR1B (ATP-bound).3 Publications

GO - Molecular functioni

  • ATPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi127870. 66 interactors.
IntActiQ8NFQ8. 9 interactors.
STRINGi9606.ENSP00000356584.

Structurei

Secondary structure

1470
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi242 – 244Combined sources3
Helixi250 – 265Combined sources16
Helixi271 – 285Combined sources15
Beta strandi294 – 300Combined sources7
Helixi302 – 304Combined sources3
Helixi305 – 319Combined sources15
Turni320 – 322Combined sources3
Beta strandi328 – 331Combined sources4
Helixi340 – 356Combined sources17
Beta strandi361 – 365Combined sources5
Helixi367 – 369Combined sources3
Helixi372 – 376Combined sources5
Helixi377 – 382Combined sources6
Turni384 – 386Combined sources3
Beta strandi393 – 399Combined sources7
Beta strandi401 – 403Combined sources3
Helixi411 – 426Combined sources16
Beta strandi428 – 431Combined sources4
Helixi440 – 450Combined sources11
Beta strandi454 – 456Combined sources3
Helixi461 – 466Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5J1SX-ray1.40B233-470[»]
5J1TX-ray1.40B233-470[»]
ProteinModelPortaliQ8NFQ8.
SMRiQ8NFQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni236 – 470Interaction with TOR1A1 PublicationAdd BLAST235

Sequence similaritiesi

Belongs to the TOR1AIP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJUB. Eukaryota.
ENOG4111IZJ. LUCA.
GeneTreeiENSGT00390000012166.
HOGENOMiHOG000154661.
HOVERGENiHBG094081.
InParanoidiQ8NFQ8.
OMAiHHVADAY.
OrthoDBiEOG091G05ZP.
PhylomeDBiQ8NFQ8.
TreeFamiTF329438.

Family and domain databases

InterProiIPR008662. Lamina-ass_polypeptide_CLAP1C.
[Graphical view]
PfamiPF05609. LAP1C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform TOR1AIP2 (identifier: Q8NFQ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADSGLREPQ EDSQKDLEND PSVNSQAQET TIIASNAEEA EILHSACGLS
60 70 80 90 100
KDHQEVETEG PESADTGDKS ESPDEANVGK HPKDKTEDEN KQSFLDGGKG
110 120 130 140 150
HHLPSENLGK EPLDPDPSHS PSDKVGRADA HLGSSSVALP KEASDGTGAS
160 170 180 190 200
QEPPTTDSQE AQSPGHSSAG QEGEDTLRRR LLAPEAGSHP QQTQKLEEIK
210 220 230 240 250
ENAQDTMRQI NKKGFWSYGP VILVVLVVAV VASSVNSYYS SPAQQVPKNP
260 270 280 290 300
ALEAFLAQFS QLEDKFPGQS SFLWQRGRKF LQKHLNASNP TEPATIIFTA
310 320 330 340 350
AREGRETLKC LSHHVADAYT SSQKVSPIQI DGAGRTWQDS DTVKLLVDLE
360 370 380 390 400
LSYGFENGQK AAVVHHFESF PAGSTLIFYK YCDHENAAFK DVALVLTVLL
410 420 430 440 450
EEETLEASVG PRETEEKVRD LLWAKFTNSD TPTSFNHMDS DKLSGLWSRI
460 470
SHLVLPVQPV SSIEEQGCLF
Length:470
Mass (Da):51,263
Last modified:October 1, 2002 - v1
Checksum:i275CB5E28B7D4338
GO
Isoform IFRG15 (identifier: Q9H496-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9H496.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available. Dubious isoform.
Length:131
Mass (Da):15,348
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF464140 mRNA. Translation: AAM50514.1.
AL359853 Genomic DNA. Translation: CAH70382.1.
BC101532 mRNA. Translation: AAI01533.1.
BC112225 mRNA. Translation: AAI12226.1.
CCDSiCCDS1334.1. [Q8NFQ8-1]
RefSeqiNP_001186189.1. NM_001199260.1. [Q8NFQ8-1]
NP_659471.1. NM_145034.4. [Q8NFQ8-1]
XP_005244996.1. XM_005244939.4. [Q8NFQ8-1]
XP_016855963.1. XM_017000474.1. [Q8NFQ8-1]
XP_016855964.1. XM_017000475.1. [Q8NFQ8-1]
UniGeneiHs.571797.
Hs.723247.

Genome annotation databases

EnsembliENST00000367612; ENSP00000356584; ENSG00000169905. [Q8NFQ8-1]
ENST00000609928; ENSP00000477486; ENSG00000169905. [Q8NFQ8-1]
GeneIDi163590.
KEGGihsa:163590.
UCSCiuc001gnk.4. human. [Q8NFQ8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF464140 mRNA. Translation: AAM50514.1.
AL359853 Genomic DNA. Translation: CAH70382.1.
BC101532 mRNA. Translation: AAI01533.1.
BC112225 mRNA. Translation: AAI12226.1.
CCDSiCCDS1334.1. [Q8NFQ8-1]
RefSeqiNP_001186189.1. NM_001199260.1. [Q8NFQ8-1]
NP_659471.1. NM_145034.4. [Q8NFQ8-1]
XP_005244996.1. XM_005244939.4. [Q8NFQ8-1]
XP_016855963.1. XM_017000474.1. [Q8NFQ8-1]
XP_016855964.1. XM_017000475.1. [Q8NFQ8-1]
UniGeneiHs.571797.
Hs.723247.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5J1SX-ray1.40B233-470[»]
5J1TX-ray1.40B233-470[»]
ProteinModelPortaliQ8NFQ8.
SMRiQ8NFQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127870. 66 interactors.
IntActiQ8NFQ8. 9 interactors.
STRINGi9606.ENSP00000356584.

PTM databases

iPTMnetiQ8NFQ8.
PhosphoSitePlusiQ8NFQ8.
SwissPalmiQ8NFQ8.

Polymorphism and mutation databases

BioMutaiTOR1AIP2.
DMDMi74751288.

Proteomic databases

EPDiQ8NFQ8.
PaxDbiQ8NFQ8.
PeptideAtlasiQ8NFQ8.
PRIDEiQ8NFQ8.

Protocols and materials databases

DNASUi163590.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367612; ENSP00000356584; ENSG00000169905. [Q8NFQ8-1]
ENST00000609928; ENSP00000477486; ENSG00000169905. [Q8NFQ8-1]
GeneIDi163590.
KEGGihsa:163590.
UCSCiuc001gnk.4. human. [Q8NFQ8-1]

Organism-specific databases

CTDi163590.
DisGeNETi163590.
GeneCardsiTOR1AIP2.
HGNCiHGNC:24055. TOR1AIP2.
HPAiHPA051849.
HPA070542.
MIMi614513. gene.
neXtProtiNX_Q8NFQ8.
OpenTargetsiENSG00000169905.
PharmGKBiPA142670716.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJUB. Eukaryota.
ENOG4111IZJ. LUCA.
GeneTreeiENSGT00390000012166.
HOGENOMiHOG000154661.
HOVERGENiHBG094081.
InParanoidiQ8NFQ8.
OMAiHHVADAY.
OrthoDBiEOG091G05ZP.
PhylomeDBiQ8NFQ8.
TreeFamiTF329438.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169905-MONOMER.

Miscellaneous databases

ChiTaRSiTOR1AIP2. human.
GenomeRNAii163590.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169905.
CleanExiHS_TOR1AIP2.
ExpressionAtlasiQ8NFQ8. baseline and differential.
GenevisibleiQ8NFQ8. HS.

Family and domain databases

InterProiIPR008662. Lamina-ass_polypeptide_CLAP1C.
[Graphical view]
PfamiPF05609. LAP1C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOIP2_HUMAN
AccessioniPrimary (citable) accession number: Q8NFQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.