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Q8NFQ6

- BPIFC_HUMAN

UniProt

Q8NFQ6 - BPIFC_HUMAN

Protein

BPI fold-containing family C protein

Gene

BPIFC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. lipopolysaccharide binding Source: UniProtKB
    2. phospholipid binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BPI fold-containing family C protein
    Alternative name(s):
    Bactericidal/permeability-increasing protein-like 2
    Short name:
    BPI-like 2
    Gene namesi
    Name:BPIFC
    Synonyms:BPIL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:16503. BPIFC.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25405.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 507484BPI fold-containing family C proteinPRO_0000017166Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi161 ↔ 200By similarity
    Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi355 – 3551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi415 – 4151N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NFQ6.
    PeptideAtlasiQ8NFQ6.
    PRIDEiQ8NFQ6.

    Expressioni

    Tissue specificityi

    Detected in the basal layer of the epidermis from inflammatory skin from psoriasis patients, but not in normal skin.

    Gene expression databases

    ArrayExpressiQ8NFQ6.
    BgeeiQ8NFQ6.
    CleanExiHS_BPIL2.
    GenevestigatoriQ8NFQ6.

    Organism-specific databases

    HPAiHPA037665.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NFQ6.
    SMRiQ8NFQ6. Positions 26-479.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG262970.
    HOGENOMiHOG000236259.
    HOVERGENiHBG105709.
    InParanoidiQ8NFQ6.
    OMAiVLYNSFA.
    OrthoDBiEOG76739B.
    PhylomeDBiQ8NFQ6.
    TreeFamiTF315617.

    Family and domain databases

    InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
    IPR001124. Lipid-bd_serum_glycop_C.
    IPR017954. Lipid-bd_serum_glycop_CS.
    IPR017942. Lipid-bd_serum_glycop_N.
    [Graphical view]
    PfamiPF01273. LBP_BPI_CETP. 1 hit.
    PF02886. LBP_BPI_CETP_C. 1 hit.
    [Graphical view]
    SMARTiSM00328. BPI1. 1 hit.
    SM00329. BPI2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55394. SSF55394. 2 hits.
    PROSITEiPS00400. LBP_BPI_CETP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NFQ6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MCTKTIPVLW GCFLLWNLYV SSSQTIYPGI KARITQRALD YGVQAGMKMI    50
    EQMLKEKKLP DLSGSESLEF LKVDYVNYNF SNIKISAFSF PNTSLAFVPG 100
    VGIKALTNHG TANISTDWGF ESPLFQDTGG ADLFLSGVYF TGIIILTRND 150
    FGHPTLKLQD CYAQLSHAHV SFSGELSVLY NSFAEPMEKP ILKNLNEMLC 200
    PIIASEVKAL NANLSTLEVL TKIDNYTLLD YSLISSPEIT ENYLDLNLKG 250
    VFYPLENLTD PPFSPVPFVL PERSNSMLYI GIAEYFFKSA SFAHFTAGVF 300
    NVTLSTEEIS NHFVQNSQGL GNVLSRIAEI YILSQPFMVR IMATEPPIIN 350
    LQPGNFTLDI PASIMMLTQP KNSTVETIVS MDFVASTSVG LVILGQRLVC 400
    SLSLNRFRLA LPESNRSNIE VLRFENILSS ILHFGVLPLA NAKLQQGFPL 450
    SNPHKFLFVN SDIEVLEGFL LISTDLKYET SSKQQPSFHV WEGLNLISRQ 500
    WRGKSAP 507
    Length:507
    Mass (Da):56,469
    Last modified:October 1, 2002 - v1
    Checksum:iCA5285C625AC06E2
    GO
    Isoform 2 (identifier: Q8NFQ6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-186: Missing.
         327-383: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:264
    Mass (Da):29,525
    Checksum:iE7A16EA4E12085F1
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti269 – 2691V → A.
    Corresponds to variant rs2076051 [ dbSNP | Ensembl ].
    VAR_024516
    Natural varianti302 – 3021V → L.
    Corresponds to variant rs5994570 [ dbSNP | Ensembl ].
    VAR_033631
    Natural varianti451 – 4511S → P.
    Corresponds to variant rs5998478 [ dbSNP | Ensembl ].
    VAR_024517
    Natural varianti479 – 4791E → A.
    Corresponds to variant rs35856742 [ dbSNP | Ensembl ].
    VAR_049741

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 186186Missing in isoform 2. 1 PublicationVSP_056033Add
    BLAST
    Alternative sequencei327 – 38357Missing in isoform 2. 1 PublicationVSP_056034Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF465766 mRNA. Translation: AAM73984.1.
    AL021937 Genomic DNA. Translation: CAI19585.1.
    BC131582 mRNA. Translation: AAI31583.1.
    CCDSiCCDS13906.1.
    RefSeqiNP_777592.1. NM_174932.2.
    XP_005261542.1. XM_005261485.1.
    UniGeneiHs.372939.
    Hs.736771.

    Genome annotation databases

    EnsembliENST00000300399; ENSP00000300399; ENSG00000184459.
    ENST00000397452; ENSP00000380594; ENSG00000184459.
    ENST00000432451; ENSP00000408920; ENSG00000184459.
    GeneIDi254240.
    KEGGihsa:254240.
    UCSCiuc003amn.2. human.

    Polymorphism databases

    DMDMi34395538.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF465766 mRNA. Translation: AAM73984.1 .
    AL021937 Genomic DNA. Translation: CAI19585.1 .
    BC131582 mRNA. Translation: AAI31583.1 .
    CCDSi CCDS13906.1.
    RefSeqi NP_777592.1. NM_174932.2.
    XP_005261542.1. XM_005261485.1.
    UniGenei Hs.372939.
    Hs.736771.

    3D structure databases

    ProteinModelPortali Q8NFQ6.
    SMRi Q8NFQ6. Positions 26-479.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 34395538.

    Proteomic databases

    PaxDbi Q8NFQ6.
    PeptideAtlasi Q8NFQ6.
    PRIDEi Q8NFQ6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300399 ; ENSP00000300399 ; ENSG00000184459 .
    ENST00000397452 ; ENSP00000380594 ; ENSG00000184459 .
    ENST00000432451 ; ENSP00000408920 ; ENSG00000184459 .
    GeneIDi 254240.
    KEGGi hsa:254240.
    UCSCi uc003amn.2. human.

    Organism-specific databases

    CTDi 254240.
    GeneCardsi GC22M032810.
    HGNCi HGNC:16503. BPIFC.
    HPAi HPA037665.
    MIMi 614109. gene.
    neXtProti NX_Q8NFQ6.
    PharmGKBi PA25405.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG262970.
    HOGENOMi HOG000236259.
    HOVERGENi HBG105709.
    InParanoidi Q8NFQ6.
    OMAi VLYNSFA.
    OrthoDBi EOG76739B.
    PhylomeDBi Q8NFQ6.
    TreeFami TF315617.

    Miscellaneous databases

    GenomeRNAii 254240.
    NextBioi 92299.
    PROi Q8NFQ6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NFQ6.
    Bgeei Q8NFQ6.
    CleanExi HS_BPIL2.
    Genevestigatori Q8NFQ6.

    Family and domain databases

    InterProi IPR017943. Bactericidal_perm-incr_a/b_dom.
    IPR001124. Lipid-bd_serum_glycop_C.
    IPR017954. Lipid-bd_serum_glycop_CS.
    IPR017942. Lipid-bd_serum_glycop_N.
    [Graphical view ]
    Pfami PF01273. LBP_BPI_CETP. 1 hit.
    PF02886. LBP_BPI_CETP_C. 1 hit.
    [Graphical view ]
    SMARTi SM00328. BPI1. 1 hit.
    SM00329. BPI2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55394. SSF55394. 2 hits.
    PROSITEi PS00400. LBP_BPI_CETP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP)."
      Mulero J.J., Boyle B.J., Bradley S., Bright J.M., Nelken S.T., Ho T.T., Mize N.K., Childs J.D., Ballinger D.G., Ford J.E., Rupp F.
      Immunogenetics 54:293-300(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Fetal skin.
    2. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

    Entry informationi

    Entry nameiBPIFC_HUMAN
    AccessioniPrimary (citable) accession number: Q8NFQ6
    Secondary accession number(s): A2RRF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3