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Q8NFQ6

- BPIFC_HUMAN

UniProt

Q8NFQ6 - BPIFC_HUMAN

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Protein
BPI fold-containing family C protein
Gene
BPIFC, BPIL2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. lipopolysaccharide binding Source: UniProtKB
  2. phospholipid binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family C protein
Alternative name(s):
Bactericidal/permeability-increasing protein-like 2
Short name:
BPI-like 2
Gene namesi
Name:BPIFC
Synonyms:BPIL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:16503. BPIFC.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25405.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 507484BPI fold-containing family C protein
PRO_0000017166Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi79 – 791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi92 – 921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi113 – 1131N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi161 ↔ 200 By similarity
Glycosylationi213 – 2131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi225 – 2251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi257 – 2571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi301 – 3011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi355 – 3551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi372 – 3721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi415 – 4151N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NFQ6.
PeptideAtlasiQ8NFQ6.
PRIDEiQ8NFQ6.

Expressioni

Tissue specificityi

Detected in the basal layer of the epidermis from inflammatory skin from psoriasis patients, but not in normal skin.

Gene expression databases

ArrayExpressiQ8NFQ6.
BgeeiQ8NFQ6.
CleanExiHS_BPIL2.
GenevestigatoriQ8NFQ6.

Organism-specific databases

HPAiHPA037665.

Structurei

3D structure databases

ProteinModelPortaliQ8NFQ6.
SMRiQ8NFQ6. Positions 26-479.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG262970.
HOGENOMiHOG000236259.
HOVERGENiHBG105709.
InParanoidiQ8NFQ6.
OMAiVLYNSFA.
OrthoDBiEOG76739B.
PhylomeDBiQ8NFQ6.
TreeFamiTF315617.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017954. Lipid-bd_serum_glycop_CS.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.
PROSITEiPS00400. LBP_BPI_CETP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NFQ6-1 [UniParc]FASTAAdd to Basket

« Hide

MCTKTIPVLW GCFLLWNLYV SSSQTIYPGI KARITQRALD YGVQAGMKMI    50
EQMLKEKKLP DLSGSESLEF LKVDYVNYNF SNIKISAFSF PNTSLAFVPG 100
VGIKALTNHG TANISTDWGF ESPLFQDTGG ADLFLSGVYF TGIIILTRND 150
FGHPTLKLQD CYAQLSHAHV SFSGELSVLY NSFAEPMEKP ILKNLNEMLC 200
PIIASEVKAL NANLSTLEVL TKIDNYTLLD YSLISSPEIT ENYLDLNLKG 250
VFYPLENLTD PPFSPVPFVL PERSNSMLYI GIAEYFFKSA SFAHFTAGVF 300
NVTLSTEEIS NHFVQNSQGL GNVLSRIAEI YILSQPFMVR IMATEPPIIN 350
LQPGNFTLDI PASIMMLTQP KNSTVETIVS MDFVASTSVG LVILGQRLVC 400
SLSLNRFRLA LPESNRSNIE VLRFENILSS ILHFGVLPLA NAKLQQGFPL 450
SNPHKFLFVN SDIEVLEGFL LISTDLKYET SSKQQPSFHV WEGLNLISRQ 500
WRGKSAP 507
Length:507
Mass (Da):56,469
Last modified:October 1, 2002 - v1
Checksum:iCA5285C625AC06E2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti269 – 2691V → A.
Corresponds to variant rs2076051 [ dbSNP | Ensembl ].
VAR_024516
Natural varianti302 – 3021V → L.
Corresponds to variant rs5994570 [ dbSNP | Ensembl ].
VAR_033631
Natural varianti451 – 4511S → P.
Corresponds to variant rs5998478 [ dbSNP | Ensembl ].
VAR_024517
Natural varianti479 – 4791E → A.
Corresponds to variant rs35856742 [ dbSNP | Ensembl ].
VAR_049741

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF465766 mRNA. Translation: AAM73984.1.
AL021937 Genomic DNA. Translation: CAI19585.1.
CCDSiCCDS13906.1.
RefSeqiNP_777592.1. NM_174932.2.
UniGeneiHs.372939.
Hs.736771.

Genome annotation databases

EnsembliENST00000300399; ENSP00000300399; ENSG00000184459.
ENST00000397452; ENSP00000380594; ENSG00000184459.
GeneIDi254240.
KEGGihsa:254240.
UCSCiuc003amn.2. human.

Polymorphism databases

DMDMi34395538.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF465766 mRNA. Translation: AAM73984.1 .
AL021937 Genomic DNA. Translation: CAI19585.1 .
CCDSi CCDS13906.1.
RefSeqi NP_777592.1. NM_174932.2.
UniGenei Hs.372939.
Hs.736771.

3D structure databases

ProteinModelPortali Q8NFQ6.
SMRi Q8NFQ6. Positions 26-479.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 34395538.

Proteomic databases

PaxDbi Q8NFQ6.
PeptideAtlasi Q8NFQ6.
PRIDEi Q8NFQ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000300399 ; ENSP00000300399 ; ENSG00000184459 .
ENST00000397452 ; ENSP00000380594 ; ENSG00000184459 .
GeneIDi 254240.
KEGGi hsa:254240.
UCSCi uc003amn.2. human.

Organism-specific databases

CTDi 254240.
GeneCardsi GC22M032810.
HGNCi HGNC:16503. BPIFC.
HPAi HPA037665.
MIMi 614109. gene.
neXtProti NX_Q8NFQ6.
PharmGKBi PA25405.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG262970.
HOGENOMi HOG000236259.
HOVERGENi HBG105709.
InParanoidi Q8NFQ6.
OMAi VLYNSFA.
OrthoDBi EOG76739B.
PhylomeDBi Q8NFQ6.
TreeFami TF315617.

Miscellaneous databases

GenomeRNAii 254240.
NextBioi 92299.
PROi Q8NFQ6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8NFQ6.
Bgeei Q8NFQ6.
CleanExi HS_BPIL2.
Genevestigatori Q8NFQ6.

Family and domain databases

InterProi IPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017954. Lipid-bd_serum_glycop_CS.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view ]
Pfami PF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view ]
SMARTi SM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view ]
SUPFAMi SSF55394. SSF55394. 2 hits.
PROSITEi PS00400. LBP_BPI_CETP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP)."
    Mulero J.J., Boyle B.J., Bradley S., Bright J.M., Nelken S.T., Ho T.T., Mize N.K., Childs J.D., Ballinger D.G., Ford J.E., Rupp F.
    Immunogenetics 54:293-300(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal skin.
  2. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiBPIFC_HUMAN
AccessioniPrimary (citable) accession number: Q8NFQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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