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Protein

BPI fold-containing family C protein

Gene

BPIFC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • lipopolysaccharide binding Source: UniProtKB
  • phospholipid binding Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31734-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family C protein
Alternative name(s):
Bactericidal/permeability-increasing protein-like 2
Short name:
BPI-like 2
Gene namesi
Name:BPIFC
Synonyms:BPIL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:16503. BPIFC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi254240.
OpenTargetsiENSG00000184459.
PharmGKBiPA25405.

Polymorphism and mutation databases

BioMutaiBPIFC.
DMDMi34395538.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001716624 – 507BPI fold-containing family C proteinAdd BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...)Sequence analysis1
Glycosylationi92N-linked (GlcNAc...)Sequence analysis1
Glycosylationi113N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi161 ↔ 200By similarity
Glycosylationi213N-linked (GlcNAc...)Sequence analysis1
Glycosylationi225N-linked (GlcNAc...)Sequence analysis1
Glycosylationi257N-linked (GlcNAc...)Sequence analysis1
Glycosylationi301N-linked (GlcNAc...)Sequence analysis1
Glycosylationi355N-linked (GlcNAc...)Sequence analysis1
Glycosylationi372N-linked (GlcNAc...)Sequence analysis1
Glycosylationi415N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NFQ6.
PeptideAtlasiQ8NFQ6.
PRIDEiQ8NFQ6.

PTM databases

iPTMnetiQ8NFQ6.
PhosphoSitePlusiQ8NFQ6.

Expressioni

Tissue specificityi

Detected in the basal layer of the epidermis from inflammatory skin from psoriasis patients, but not in normal skin.

Gene expression databases

BgeeiENSG00000184459.
CleanExiHS_BPIL2.
ExpressionAtlasiQ8NFQ6. baseline and differential.
GenevisibleiQ8NFQ6. HS.

Organism-specific databases

HPAiHPA037665.
HPA043306.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000300399.

Structurei

3D structure databases

ProteinModelPortaliQ8NFQ6.
SMRiQ8NFQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4160. Eukaryota.
ENOG410Z88E. LUCA.
GeneTreeiENSGT00730000110583.
HOGENOMiHOG000236259.
HOVERGENiHBG105709.
InParanoidiQ8NFQ6.
OMAiVQAGMEM.
OrthoDBiEOG091G069B.
PhylomeDBiQ8NFQ6.
TreeFamiTF315617.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR030675. BPI/LBP.
IPR032942. BPI/LBP/Plunc.
IPR032950. BPIFC.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017954. Lipid-bd_serum_glycop_CS.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504. PTHR10504. 1 hit.
PTHR10504:SF17. PTHR10504:SF17. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002417. Lipid_binding_protein. 1 hit.
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.
PROSITEiPS00400. LBP_BPI_CETP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NFQ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCTKTIPVLW GCFLLWNLYV SSSQTIYPGI KARITQRALD YGVQAGMKMI
60 70 80 90 100
EQMLKEKKLP DLSGSESLEF LKVDYVNYNF SNIKISAFSF PNTSLAFVPG
110 120 130 140 150
VGIKALTNHG TANISTDWGF ESPLFQDTGG ADLFLSGVYF TGIIILTRND
160 170 180 190 200
FGHPTLKLQD CYAQLSHAHV SFSGELSVLY NSFAEPMEKP ILKNLNEMLC
210 220 230 240 250
PIIASEVKAL NANLSTLEVL TKIDNYTLLD YSLISSPEIT ENYLDLNLKG
260 270 280 290 300
VFYPLENLTD PPFSPVPFVL PERSNSMLYI GIAEYFFKSA SFAHFTAGVF
310 320 330 340 350
NVTLSTEEIS NHFVQNSQGL GNVLSRIAEI YILSQPFMVR IMATEPPIIN
360 370 380 390 400
LQPGNFTLDI PASIMMLTQP KNSTVETIVS MDFVASTSVG LVILGQRLVC
410 420 430 440 450
SLSLNRFRLA LPESNRSNIE VLRFENILSS ILHFGVLPLA NAKLQQGFPL
460 470 480 490 500
SNPHKFLFVN SDIEVLEGFL LISTDLKYET SSKQQPSFHV WEGLNLISRQ

WRGKSAP
Length:507
Mass (Da):56,469
Last modified:October 1, 2002 - v1
Checksum:iCA5285C625AC06E2
GO
Isoform 2 (identifier: Q8NFQ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-186: Missing.
     327-383: Missing.

Note: No experimental confirmation available.
Show »
Length:264
Mass (Da):29,525
Checksum:iE7A16EA4E12085F1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024516269V → A.Corresponds to variant rs2076051dbSNPEnsembl.1
Natural variantiVAR_033631302V → L.Corresponds to variant rs5994570dbSNPEnsembl.1
Natural variantiVAR_024517451S → P.Corresponds to variant rs5998478dbSNPEnsembl.1
Natural variantiVAR_049741479E → A.Corresponds to variant rs35856742dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0560331 – 186Missing in isoform 2. 1 PublicationAdd BLAST186
Alternative sequenceiVSP_056034327 – 383Missing in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465766 mRNA. Translation: AAM73984.1.
AL021937 Genomic DNA. Translation: CAI19585.1.
BC131582 mRNA. Translation: AAI31583.1.
CCDSiCCDS13906.1. [Q8NFQ6-1]
RefSeqiNP_777592.1. NM_174932.2. [Q8NFQ6-1]
XP_011528390.1. XM_011530088.2. [Q8NFQ6-1]
XP_011528391.1. XM_011530089.1. [Q8NFQ6-1]
XP_011528392.1. XM_011530090.1. [Q8NFQ6-1]
UniGeneiHs.372939.
Hs.736771.

Genome annotation databases

EnsembliENST00000300399; ENSP00000300399; ENSG00000184459. [Q8NFQ6-1]
ENST00000397452; ENSP00000380594; ENSG00000184459. [Q8NFQ6-1]
ENST00000534972; ENSP00000439123; ENSG00000184459. [Q8NFQ6-2]
GeneIDi254240.
KEGGihsa:254240.
UCSCiuc003amn.2. human. [Q8NFQ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465766 mRNA. Translation: AAM73984.1.
AL021937 Genomic DNA. Translation: CAI19585.1.
BC131582 mRNA. Translation: AAI31583.1.
CCDSiCCDS13906.1. [Q8NFQ6-1]
RefSeqiNP_777592.1. NM_174932.2. [Q8NFQ6-1]
XP_011528390.1. XM_011530088.2. [Q8NFQ6-1]
XP_011528391.1. XM_011530089.1. [Q8NFQ6-1]
XP_011528392.1. XM_011530090.1. [Q8NFQ6-1]
UniGeneiHs.372939.
Hs.736771.

3D structure databases

ProteinModelPortaliQ8NFQ6.
SMRiQ8NFQ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000300399.

PTM databases

iPTMnetiQ8NFQ6.
PhosphoSitePlusiQ8NFQ6.

Polymorphism and mutation databases

BioMutaiBPIFC.
DMDMi34395538.

Proteomic databases

PaxDbiQ8NFQ6.
PeptideAtlasiQ8NFQ6.
PRIDEiQ8NFQ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300399; ENSP00000300399; ENSG00000184459. [Q8NFQ6-1]
ENST00000397452; ENSP00000380594; ENSG00000184459. [Q8NFQ6-1]
ENST00000534972; ENSP00000439123; ENSG00000184459. [Q8NFQ6-2]
GeneIDi254240.
KEGGihsa:254240.
UCSCiuc003amn.2. human. [Q8NFQ6-1]

Organism-specific databases

CTDi254240.
DisGeNETi254240.
GeneCardsiBPIFC.
HGNCiHGNC:16503. BPIFC.
HPAiHPA037665.
HPA043306.
MIMi614109. gene.
neXtProtiNX_Q8NFQ6.
OpenTargetsiENSG00000184459.
PharmGKBiPA25405.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4160. Eukaryota.
ENOG410Z88E. LUCA.
GeneTreeiENSGT00730000110583.
HOGENOMiHOG000236259.
HOVERGENiHBG105709.
InParanoidiQ8NFQ6.
OMAiVQAGMEM.
OrthoDBiEOG091G069B.
PhylomeDBiQ8NFQ6.
TreeFamiTF315617.

Enzyme and pathway databases

BioCyciZFISH:G66-31734-MONOMER.

Miscellaneous databases

GenomeRNAii254240.
PROiQ8NFQ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184459.
CleanExiHS_BPIL2.
ExpressionAtlasiQ8NFQ6. baseline and differential.
GenevisibleiQ8NFQ6. HS.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR030675. BPI/LBP.
IPR032942. BPI/LBP/Plunc.
IPR032950. BPIFC.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017954. Lipid-bd_serum_glycop_CS.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504. PTHR10504. 1 hit.
PTHR10504:SF17. PTHR10504:SF17. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002417. Lipid_binding_protein. 1 hit.
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.
PROSITEiPS00400. LBP_BPI_CETP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBPIFC_HUMAN
AccessioniPrimary (citable) accession number: Q8NFQ6
Secondary accession number(s): A2RRF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.