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Q8NFQ6 (BPIFC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
BPI fold-containing family C protein
Alternative name(s):
Bactericidal/permeability-increasing protein-like 2
Short name=BPI-like 2
Gene names
Name:BPIFC
Synonyms:BPIL2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted By similarity.

Tissue specificity

Detected in the basal layer of the epidermis from inflammatory skin from psoriasis patients, but not in normal skin.

Sequence similarities

Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlipopolysaccharide binding

Non-traceable author statement Ref.1. Source: UniProtKB

phospholipid binding

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 507484BPI fold-containing family C protein
PRO_0000017166

Amino acid modifications

Glycosylation791N-linked (GlcNAc...) Potential
Glycosylation921N-linked (GlcNAc...) Potential
Glycosylation1131N-linked (GlcNAc...) Potential
Glycosylation2131N-linked (GlcNAc...) Potential
Glycosylation2251N-linked (GlcNAc...) Potential
Glycosylation2571N-linked (GlcNAc...) Potential
Glycosylation3011N-linked (GlcNAc...) Potential
Glycosylation3551N-linked (GlcNAc...) Potential
Glycosylation3721N-linked (GlcNAc...) Potential
Glycosylation4151N-linked (GlcNAc...) Potential
Disulfide bond161 ↔ 200 By similarity

Natural variations

Natural variant2691V → A.
Corresponds to variant rs2076051 [ dbSNP | Ensembl ].
VAR_024516
Natural variant3021V → L.
Corresponds to variant rs5994570 [ dbSNP | Ensembl ].
VAR_033631
Natural variant4511S → P.
Corresponds to variant rs5998478 [ dbSNP | Ensembl ].
VAR_024517
Natural variant4791E → A.
Corresponds to variant rs35856742 [ dbSNP | Ensembl ].
VAR_049741

Sequences

Sequence LengthMass (Da)Tools
Q8NFQ6 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: CA5285C625AC06E2

FASTA50756,469
        10         20         30         40         50         60 
MCTKTIPVLW GCFLLWNLYV SSSQTIYPGI KARITQRALD YGVQAGMKMI EQMLKEKKLP 

        70         80         90        100        110        120 
DLSGSESLEF LKVDYVNYNF SNIKISAFSF PNTSLAFVPG VGIKALTNHG TANISTDWGF 

       130        140        150        160        170        180 
ESPLFQDTGG ADLFLSGVYF TGIIILTRND FGHPTLKLQD CYAQLSHAHV SFSGELSVLY 

       190        200        210        220        230        240 
NSFAEPMEKP ILKNLNEMLC PIIASEVKAL NANLSTLEVL TKIDNYTLLD YSLISSPEIT 

       250        260        270        280        290        300 
ENYLDLNLKG VFYPLENLTD PPFSPVPFVL PERSNSMLYI GIAEYFFKSA SFAHFTAGVF 

       310        320        330        340        350        360 
NVTLSTEEIS NHFVQNSQGL GNVLSRIAEI YILSQPFMVR IMATEPPIIN LQPGNFTLDI 

       370        380        390        400        410        420 
PASIMMLTQP KNSTVETIVS MDFVASTSVG LVILGQRLVC SLSLNRFRLA LPESNRSNIE 

       430        440        450        460        470        480 
VLRFENILSS ILHFGVLPLA NAKLQQGFPL SNPHKFLFVN SDIEVLEGFL LISTDLKYET 

       490        500 
SSKQQPSFHV WEGLNLISRQ WRGKSAP 

« Hide

References

« Hide 'large scale' references
[1]"Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP)."
Mulero J.J., Boyle B.J., Bradley S., Bright J.M., Nelken S.T., Ho T.T., Mize N.K., Childs J.D., Ballinger D.G., Ford J.E., Rupp F.
Immunogenetics 54:293-300(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal skin.
[2]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF465766 mRNA. Translation: AAM73984.1.
AL021937 Genomic DNA. Translation: CAI19585.1.
RefSeqNP_777592.1. NM_174932.2.
UniGeneHs.372939.
Hs.736771.

3D structure databases

ProteinModelPortalQ8NFQ6.
SMRQ8NFQ6. Positions 26-479.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM34395538.

Proteomic databases

PaxDbQ8NFQ6.
PeptideAtlasQ8NFQ6.
PRIDEQ8NFQ6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000300399; ENSP00000300399; ENSG00000184459.
ENST00000397452; ENSP00000380594; ENSG00000184459.
GeneID254240.
KEGGhsa:254240.
UCSCuc003amn.2. human.

Organism-specific databases

CTD254240.
GeneCardsGC22M032810.
HGNCHGNC:16503. BPIFC.
HPAHPA037665.
MIM614109. gene.
neXtProtNX_Q8NFQ6.
PharmGKBPA25405.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG262970.
HOGENOMHOG000236259.
HOVERGENHBG105709.
InParanoidQ8NFQ6.
OMAVLYNSFA.
OrthoDBEOG76739B.
PhylomeDBQ8NFQ6.
TreeFamTF315617.

Gene expression databases

ArrayExpressQ8NFQ6.
BgeeQ8NFQ6.
CleanExHS_BPIL2.
GenevestigatorQ8NFQ6.

Family and domain databases

InterProIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017954. Lipid-bd_serum_glycop_CS.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PfamPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMSSF55394. SSF55394. 2 hits.
PROSITEPS00400. LBP_BPI_CETP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi254240.
NextBio92299.
PROQ8NFQ6.
SOURCESearch...

Entry information

Entry nameBPIFC_HUMAN
AccessionPrimary (citable) accession number: Q8NFQ6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: October 1, 2002
Last modified: March 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM