Q8NFQ6 (BPIFC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BPI fold-containing family C protein

Alternative name(s):
Bactericidal/permeability-increasing protein-like 2
Short name=BPI-like 2

Gene names

Name:	BPIFC
Synonyms:	BPIL2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted By similarity.
Tissue specificity	Detected in the basal layer of the epidermis from inflammatory skin from psoriasis patients, but not in normal skin.
Sequence similarities	Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Non-traceable author statement. Source: UniProtKB
Molecular_function	lipopolysaccharide binding Non-traceable author statement Ref.1. Source: UniProtKB phospholipid binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 507	484	BPI fold-containing family C protein		PRO_0000017166
Amino acid modifications
	Glycosylation	79	1	N-linked (GlcNAc...) Potential
	Glycosylation	92	1	N-linked (GlcNAc...) Potential
	Glycosylation	113	1	N-linked (GlcNAc...) Potential
	Glycosylation	213	1	N-linked (GlcNAc...) Potential
	Glycosylation	225	1	N-linked (GlcNAc...) Potential
	Glycosylation	257	1	N-linked (GlcNAc...) Potential
	Glycosylation	301	1	N-linked (GlcNAc...) Potential
	Glycosylation	355	1	N-linked (GlcNAc...) Potential
	Glycosylation	372	1	N-linked (GlcNAc...) Potential
	Glycosylation	415	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	269	1	V → A. Corresponds to variant rs2076051 [ dbSNP | Ensembl ].		VAR_024516
	Natural variant	302	1	V → L. Corresponds to variant rs5994570 [ dbSNP | Ensembl ].		VAR_033631
	Natural variant	451	1	S → P. Corresponds to variant rs5998478 [ dbSNP | Ensembl ].		VAR_024517
	Natural variant	479	1	E → A. Corresponds to variant rs35856742 [ dbSNP | Ensembl ].		VAR_049741

Sequences

	Sequence		Length	Mass (Da)
	Q8NFQ6 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: CA5285C625AC06E2	FASTA	507	56,469
	10 20 30 40 50 60 MCTKTIPVLW GCFLLWNLYV SSSQTIYPGI KARITQRALD YGVQAGMKMI EQMLKEKKLP 70 80 90 100 110 120 DLSGSESLEF LKVDYVNYNF SNIKISAFSF PNTSLAFVPG VGIKALTNHG TANISTDWGF 130 140 150 160 170 180 ESPLFQDTGG ADLFLSGVYF TGIIILTRND FGHPTLKLQD CYAQLSHAHV SFSGELSVLY 190 200 210 220 230 240 NSFAEPMEKP ILKNLNEMLC PIIASEVKAL NANLSTLEVL TKIDNYTLLD YSLISSPEIT 250 260 270 280 290 300 ENYLDLNLKG VFYPLENLTD PPFSPVPFVL PERSNSMLYI GIAEYFFKSA SFAHFTAGVF 310 320 330 340 350 360 NVTLSTEEIS NHFVQNSQGL GNVLSRIAEI YILSQPFMVR IMATEPPIIN LQPGNFTLDI 370 380 390 400 410 420 PASIMMLTQP KNSTVETIVS MDFVASTSVG LVILGQRLVC SLSLNRFRLA LPESNRSNIE 430 440 450 460 470 480 VLRFENILSS ILHFGVLPLA NAKLQQGFPL SNPHKFLFVN SDIEVLEGFL LISTDLKYET 490 500 SSKQQPSFHV WEGLNLISRQ WRGKSAP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP)." Mulero J.J., Boyle B.J., Bradley S., Bright J.M., Nelken S.T., Ho T.T., Mize N.K., Childs J.D., Ballinger D.G., Ford J.E., Rupp F. Immunogenetics 54:293-300(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal skin.
[2]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF465766 mRNA. Translation: AAM73984.1. AL021937 Genomic DNA. Translation: CAI19585.1.
IPI	IPI00168874.
RefSeq	NP_777592.1. NM_174932.2.
UniGene	Hs.372939. Hs.736771.
3D structure databases
ProteinModelPortal	Q8NFQ6.
ModBase	Search...
Polymorphism databases
DMDM	34395538.
Proteomic databases
PaxDb	Q8NFQ6.
PeptideAtlas	Q8NFQ6.
PRIDE	Q8NFQ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000300399; ENSP00000300399; ENSG00000184459. ENST00000397452; ENSP00000380594; ENSG00000184459.
GeneID	254240.
KEGG	hsa:254240.
UCSC	uc003amn.2. human.
Organism-specific databases
CTD	254240.
GeneCards	GC22M032810.
HGNC	HGNC:16503. BPIFC.
HPA	HPA037665.
MIM	614109. gene.
neXtProt	NX_Q8NFQ6.
PharmGKB	PA25405.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG262970.
HOGENOM	HOG000236259.
HOVERGEN	HBG105709.
InParanoid	Q8NFQ6.
OMA	VLYNSFA.
OrthoDB	EOG4M398B.
PhylomeDB	Q8NFQ6.
Gene expression databases
ArrayExpress	Q8NFQ6.
Bgee	Q8NFQ6.
CleanEx	HS_BPIL2.
Genevestigator	Q8NFQ6.
GermOnline	ENSG00000184459. Homo sapiens.
Family and domain databases
InterPro	IPR017943. Bactericidal_perm-incr_a/b_dom. IPR001124. Lipid-bd_serum_glycop_C. IPR017954. Lipid-bd_serum_glycop_CS. IPR017942. Lipid-bd_serum_glycop_N. [Graphical view]
Pfam	PF01273. LBP_BPI_CETP. 1 hit. PF02886. LBP_BPI_CETP_C. 1 hit. [Graphical view]
SMART	SM00328. BPI1. 1 hit. SM00329. BPI2. 1 hit. [Graphical view]
SUPFAM	SSF55394. Bactericidal_perm-incr_a/b_dom. 2 hits.
PROSITE	PS00400. LBP_BPI_CETP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	254240.
NextBio	92299.
SOURCE	Search...

Entry information

Entry name

BPIFC_HUMAN

Accession

Primary (citable) accession number: Q8NFQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.