Q8NFQ5 (BPIB6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BPI fold-containing family B member 6

Alternative name(s):
Bactericidal/permeability-increasing protein-like 3

Gene names

Name:	BPIFB6
Synonyms:	BPIL3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	453 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted By similarity.
Tissue specificity	Detected at very low levels in normal tonsils, and at higher levels in hypertrophic tonsils.
Sequence similarities	Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	lipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 453	435	BPI fold-containing family B member 6		PRO_0000017168
Amino acid modifications
	Glycosylation	114	1	N-linked (GlcNAc...) Potential
	Glycosylation	190	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	16	1	T → M. Corresponds to variant rs17301126 [ dbSNP | Ensembl ].		VAR_033632
	Natural variant	97	1	V → I. Corresponds to variant rs2070317 [ dbSNP | Ensembl ].		VAR_024518
	Natural variant	149	1	P → T. Corresponds to variant rs11907355 [ dbSNP | Ensembl ].		VAR_033633
	Natural variant	296	1	R → H De novo variant found in a patient with mental retardation. Ref.4		VAR_065088
	Natural variant	347	1	S → G. Corresponds to variant rs4911287 [ dbSNP | Ensembl ].		VAR_033634

Sequences

	Sequence		Length	Mass (Da)
	Q8NFQ5 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 19379CA22A41CE5C	FASTA	453	49,717
	10 20 30 40 50 60 MLRILCLALC SLLTGTRADP GALLRLGMDI MNQVQSAMDE SHILEKMAAE AGKKQPGMKP 70 80 90 100 110 120 IKGITNLKVK DVQLPVITLN FVPGVGIFQC VSTGMTVTGK SFMGGNMEII VALNITATNR 130 140 150 160 170 180 LLRDEETGLP VFKSEGCEVI LVNVKTNLPS NMLPKMVNKF LDSTLHKVLP GLMCPAIDAV 190 200 210 220 230 240 LVYVNRKWTN LSDPMPVGQM GTVKYVLMSA PATTASYIQL DFSPVVQQQK GKTIKLADAG 250 260 270 280 290 300 EALTFPEGYA KGSSQLLLPA TFLSAELALL QKSFHVNIQD TMIGELPPQT TKTLARFIPE 310 320 330 340 350 360 VAVAYPKSKP LTTQIKIKKP PKVTMKTGKS LLHLHSTLEM FAARWRSKAP MSLFLLEVHF 370 380 390 400 410 420 NLKVQYSVHE NQLQMATSLD RLLSLSRKSS SIGNFNEREL TGFITSYLEE AYIPVVNDVL 430 440 450 QVGLPLPDFL AMNYNLAELD IVENALMLDL KLG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP)." Mulero J.J., Boyle B.J., Bradley S., Bright J.M., Nelken S.T., Ho T.T., Mize N.K., Childs J.D., Ballinger D.G., Ford J.E., Rupp F. Immunogenetics 54:293-300(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Tonsil.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[4]	"A de novo paradigm for mental retardation." Vissers L.E., de Ligt J., Gilissen C., Janssen I., Steehouwer M., de Vries P., van Lier B., Arts P., Wieskamp N., del Rosario M., van Bon B.W., Hoischen A., de Vries B.B., Brunner H.G., Veltman J.A. Nat. Genet. 42:1109-1112(2010) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT HIS-296.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF465767 mRNA. Translation: AAM73985.1. AL121756 Genomic DNA. Translation: CAI22530.1.
IPI	IPI00414328.
RefSeq	NP_777557.1. NM_174897.2.
UniGene	Hs.375090.
3D structure databases
ProteinModelPortal	Q8NFQ5.
SMR	Q8NFQ5. Positions 18-453.
ModBase	Search...
PTM databases
PhosphoSite	Q8NFQ5.
Polymorphism databases
DMDM	34395537.
Proteomic databases
PaxDb	Q8NFQ5.
PRIDE	Q8NFQ5.
Protocols and materials databases
DNASU	128859.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000349552; ENSP00000344929; ENSG00000167104.
GeneID	128859.
KEGG	hsa:128859.
UCSC	uc010zuc.2. human.
Organism-specific databases
CTD	128859.
GeneCards	GC20P031620.
HGNC	HGNC:16504. BPIFB6.
HPA	HPA043057.
MIM	614110. gene.
neXtProt	NX_Q8NFQ5.
PharmGKB	PA25406.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG276086.
HOGENOM	HOG000231740.
HOVERGEN	HBG095916.
InParanoid	Q8NFQ5.
OMA	YIPVVND.
OrthoDB	EOG46Q6SJ.
PhylomeDB	Q8NFQ5.
Gene expression databases
ArrayExpress	Q8NFQ5.
Bgee	Q8NFQ5.
CleanEx	HS_BPIL3.
Genevestigator	Q8NFQ5.
GermOnline	ENSG00000167104. Homo sapiens.
Family and domain databases
InterPro	IPR017943. Bactericidal_perm-incr_a/b_dom. IPR001124. Lipid-bd_serum_glycop_C. IPR017942. Lipid-bd_serum_glycop_N. [Graphical view]
Pfam	PF01273. LBP_BPI_CETP. 1 hit. PF02886. LBP_BPI_CETP_C. 1 hit. [Graphical view]
SMART	SM00328. BPI1. 1 hit. SM00329. BPI2. 1 hit. [Graphical view]
SUPFAM	SSF55394. Bactericidal_perm-incr_a/b_dom. 2 hits.
PROSITE	PS00400. LBP_BPI_CETP. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	128859.
NextBio	82486.
SOURCE	Search...

Entry information

Entry name

BPIB6_HUMAN

Accession

Primary (citable) accession number: Q8NFQ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.