Reviewed, UniProtKB/Swiss-Prot Q8NFQ5 (BPIL3_HUMAN)

Names and origin

Protein names

Recommended name:
    Bactericidal/permeability-increasing protein-like 3

Gene names

Name:

BPIL3

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	453 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Secreted By similarity.
Tissue specificity	Detected at very low levels in normal tonsils, and at higher levels in hypertrophic tonsils.
Sequence similarities	Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	lipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 453	435	Bactericidal/permeability-increasing protein-like 3		PRO_0000017168
Amino acid modifications
	Glycosylation	114	1	N-linked (GlcNAc...) Potential
	Glycosylation	190	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	16	1	T → M: dbSNP rs17301126.		VAR_033632
	Natural variant	97	1	V → I: dbSNP rs2070317.		VAR_024518
	Natural variant	149	1	P → T: dbSNP rs11907355.		VAR_033633
	Natural variant	347	1	S → G: dbSNP rs4911287.		VAR_033634

Sequences

	Sequence		Length	Mass (Da)
	Q8NFQ5-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 19379CA22A41CE5C	FASTA	453	49,717
	10 20 30 40 50 60 MLRILCLALC SLLTGTRADP GALLRLGMDI MNQVQSAMDE SHILEKMAAE AGKKQPGMKP 70 80 90 100 110 120 IKGITNLKVK DVQLPVITLN FVPGVGIFQC VSTGMTVTGK SFMGGNMEII VALNITATNR 130 140 150 160 170 180 LLRDEETGLP VFKSEGCEVI LVNVKTNLPS NMLPKMVNKF LDSTLHKVLP GLMCPAIDAV 190 200 210 220 230 240 LVYVNRKWTN LSDPMPVGQM GTVKYVLMSA PATTASYIQL DFSPVVQQQK GKTIKLADAG 250 260 270 280 290 300 EALTFPEGYA KGSSQLLLPA TFLSAELALL QKSFHVNIQD TMIGELPPQT TKTLARFIPE 310 320 330 340 350 360 VAVAYPKSKP LTTQIKIKKP PKVTMKTGKS LLHLHSTLEM FAARWRSKAP MSLFLLEVHF 370 380 390 400 410 420 NLKVQYSVHE NQLQMATSLD RLLSLSRKSS SIGNFNEREL TGFITSYLEE AYIPVVNDVL 430 440 450 QVGLPLPDFL AMNYNLAELD IVENALMLDL KLG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP)." Mulero J.J., Boyle B.J., Bradley S., Bright J.M., Nelken S.T., Ho T.T., Mize N.K., Childs J.D., Ballinger D.G., Ford J.E., Rupp F. Immunogenetics 54:293-300(2002) [PubMed: 12185532] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Tonsil.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF465767 mRNA. Translation: AAM73985.1. AL121756 Genomic DNA. Translation: CAI22530.1.
IPI	IPI00414328.
RefSeq	NP_777557.1.
UniGene	Hs.375090
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q8NFQ5.
Proteomic databases
PRIDE	Q8NFQ5.
Genome annotation databases
Ensembl	ENST00000349552; ENSP00000344929; ENSG00000167104; Homo sapiens. [Genome view]
GeneID	128859.
KEGG	hsa:128859.
UCSC	uc002wyk.1. human.
Organism-specific databases
CTD	128859.
GeneCards	GC20P031083.
H-InvDB	HIX0040526.
HGNC	HGNC:16504. BPIL3.
PharmGKB	PA25406.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8NFQ5.
HOVERGEN	Q8NFQ5.
OMA	GLMCPAI
OrthoDB	EOG9QNQG9
Gene expression databases
ArrayExpress	Q8NFQ5.
Bgee	Q8NFQ5.
CleanEx	HS_BPIL3.
Genevestigator	Q8NFQ5.
GermOnline	ENSG00000167104. Homo sapiens.
Family and domain databases
InterPro	IPR017943. Bactericidal_perm-incr_a/b_dom. IPR017942. Lipid-bd_serum_glycop_N. IPR001124. Lipid_bd_serum_glycop_C. [Graphical view]
Pfam	PF01273. LBP_BPI_CETP. 1 hit. PF02886. LBP_BPI_CETP_C. 1 hit. [Graphical view]
SMART	SM00328. BPI1. 1 hit. SM00329. BPI2. 1 hit. [Graphical view]
PROSITE	PS00400. LBP_BPI_CETP. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	82486.

Entry information

Entry name

BPIL3_HUMAN

Accession

Primary (citable) accession number: Q8NFQ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	October 1, 2002
Last modified:	November 24, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.