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Protein

BPI fold-containing family B member 6

Gene

BPIFB6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-HSA-6803157. Antimicrobial peptides.

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family B member 6
Alternative name(s):
Bactericidal/permeability-increasing protein-like 3
Gene namesi
Name:BPIFB6
Synonyms:BPIL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000167104.11.
HGNCiHGNC:16504. BPIFB6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25406.

Polymorphism and mutation databases

BioMutaiBPIFB6.
DMDMi34395537.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001716819 – 453BPI fold-containing family B member 6Add BLAST435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi137 ↔ 174By similarity
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8NFQ5.
PaxDbiQ8NFQ5.
PeptideAtlasiQ8NFQ5.
PRIDEiQ8NFQ5.

PTM databases

PhosphoSitePlusiQ8NFQ5.

Expressioni

Tissue specificityi

Detected at very low levels in normal tonsils, and at higher levels in hypertrophic tonsils.

Gene expression databases

BgeeiENSG00000167104.
CleanExiHS_BPIL3.
ExpressionAtlasiQ8NFQ5. baseline and differential.
GenevisibleiQ8NFQ5. HS.

Organism-specific databases

HPAiHPA043057.

Structurei

3D structure databases

ProteinModelPortaliQ8NFQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4160. Eukaryota.
ENOG410Z88E. LUCA.
GeneTreeiENSGT00730000110772.
HOGENOMiHOG000231740.
HOVERGENiHBG095916.
InParanoidiQ8NFQ5.
OMAiMTITGKS.
OrthoDBiEOG091G048N.
PhylomeDBiQ8NFQ5.
TreeFamiTF315617.

Family and domain databases

InterProiView protein in InterPro
IPR017943. Bactericidal_perm-incr_a/b_dom.
IPR032942. BPI/LBP/Plunc.
IPR032948. BPIFB6.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
PANTHERiPTHR10504. PTHR10504. 1 hit.
PTHR10504:SF99. PTHR10504:SF99. 1 hit.
PfamiView protein in Pfam
PF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
SMARTiView protein in SMART
SM00329. BPI2. 1 hit.
SUPFAMiSSF55394. SSF55394. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NFQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRILCLALC SLLTGTRADP GALLRLGMDI MNQVQSAMDE SHILEKMAAE
60 70 80 90 100
AGKKQPGMKP IKGITNLKVK DVQLPVITLN FVPGVGIFQC VSTGMTVTGK
110 120 130 140 150
SFMGGNMEII VALNITATNR LLRDEETGLP VFKSEGCEVI LVNVKTNLPS
160 170 180 190 200
NMLPKMVNKF LDSTLHKVLP GLMCPAIDAV LVYVNRKWTN LSDPMPVGQM
210 220 230 240 250
GTVKYVLMSA PATTASYIQL DFSPVVQQQK GKTIKLADAG EALTFPEGYA
260 270 280 290 300
KGSSQLLLPA TFLSAELALL QKSFHVNIQD TMIGELPPQT TKTLARFIPE
310 320 330 340 350
VAVAYPKSKP LTTQIKIKKP PKVTMKTGKS LLHLHSTLEM FAARWRSKAP
360 370 380 390 400
MSLFLLEVHF NLKVQYSVHE NQLQMATSLD RLLSLSRKSS SIGNFNEREL
410 420 430 440 450
TGFITSYLEE AYIPVVNDVL QVGLPLPDFL AMNYNLAELD IVENALMLDL

KLG
Length:453
Mass (Da):49,717
Last modified:October 1, 2002 - v1
Checksum:i19379CA22A41CE5C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03363216T → M. Corresponds to variant dbSNP:rs17301126Ensembl.1
Natural variantiVAR_02451897V → I. Corresponds to variant dbSNP:rs2070317Ensembl.1
Natural variantiVAR_033633149P → T. Corresponds to variant dbSNP:rs11907355Ensembl.1
Natural variantiVAR_065088296R → H De novo variant found in a patient with mental retardation. 1 PublicationCorresponds to variant dbSNP:rs79809934Ensembl.1
Natural variantiVAR_033634347S → G. Corresponds to variant dbSNP:rs4911287Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465767 mRNA. Translation: AAM73985.1.
AL121756 Genomic DNA. No translation available.
CCDSiCCDS13211.1.
RefSeqiNP_777557.1. NM_174897.2.
UniGeneiHs.375090.

Genome annotation databases

EnsembliENST00000349552; ENSP00000344929; ENSG00000167104.
GeneIDi128859.
KEGGihsa:128859.
UCSCiuc010zuc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBPIB6_HUMAN
AccessioniPrimary (citable) accession number: Q8NFQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families