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Q8NFQ5 (BPIB6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
BPI fold-containing family B member 6
Alternative name(s):
Bactericidal/permeability-increasing protein-like 3
Gene names
Name:BPIFB6
Synonyms:BPIL3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted By similarity.

Tissue specificity

Detected at very low levels in normal tonsils, and at higher levels in hypertrophic tonsils.

Sequence similarities

Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlipid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 453435BPI fold-containing family B member 6
PRO_0000017168

Amino acid modifications

Glycosylation1141N-linked (GlcNAc...) Potential
Glycosylation1901N-linked (GlcNAc...) Potential
Disulfide bond137 ↔ 174 By similarity

Natural variations

Natural variant161T → M.
Corresponds to variant rs17301126 [ dbSNP | Ensembl ].
VAR_033632
Natural variant971V → I.
Corresponds to variant rs2070317 [ dbSNP | Ensembl ].
VAR_024518
Natural variant1491P → T.
Corresponds to variant rs11907355 [ dbSNP | Ensembl ].
VAR_033633
Natural variant2961R → H De novo variant found in a patient with mental retardation. Ref.4
Corresponds to variant rs79809934 [ dbSNP | Ensembl ].
VAR_065088
Natural variant3471S → G.
Corresponds to variant rs4911287 [ dbSNP | Ensembl ].
VAR_033634

Sequences

Sequence LengthMass (Da)Tools
Q8NFQ5 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 19379CA22A41CE5C

FASTA45349,717
        10         20         30         40         50         60 
MLRILCLALC SLLTGTRADP GALLRLGMDI MNQVQSAMDE SHILEKMAAE AGKKQPGMKP 

        70         80         90        100        110        120 
IKGITNLKVK DVQLPVITLN FVPGVGIFQC VSTGMTVTGK SFMGGNMEII VALNITATNR 

       130        140        150        160        170        180 
LLRDEETGLP VFKSEGCEVI LVNVKTNLPS NMLPKMVNKF LDSTLHKVLP GLMCPAIDAV 

       190        200        210        220        230        240 
LVYVNRKWTN LSDPMPVGQM GTVKYVLMSA PATTASYIQL DFSPVVQQQK GKTIKLADAG 

       250        260        270        280        290        300 
EALTFPEGYA KGSSQLLLPA TFLSAELALL QKSFHVNIQD TMIGELPPQT TKTLARFIPE 

       310        320        330        340        350        360 
VAVAYPKSKP LTTQIKIKKP PKVTMKTGKS LLHLHSTLEM FAARWRSKAP MSLFLLEVHF 

       370        380        390        400        410        420 
NLKVQYSVHE NQLQMATSLD RLLSLSRKSS SIGNFNEREL TGFITSYLEE AYIPVVNDVL 

       430        440        450 
QVGLPLPDFL AMNYNLAELD IVENALMLDL KLG 

« Hide

References

« Hide 'large scale' references
[1]"Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP)."
Mulero J.J., Boyle B.J., Bradley S., Bright J.M., Nelken S.T., Ho T.T., Mize N.K., Childs J.D., Ballinger D.G., Ford J.E., Rupp F.
Immunogenetics 54:293-300(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Tonsil.
[2]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[4]"A de novo paradigm for mental retardation."
Vissers L.E., de Ligt J., Gilissen C., Janssen I., Steehouwer M., de Vries P., van Lier B., Arts P., Wieskamp N., del Rosario M., van Bon B.W., Hoischen A., de Vries B.B., Brunner H.G., Veltman J.A.
Nat. Genet. 42:1109-1112(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT HIS-296.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF465767 mRNA. Translation: AAM73985.1.
AL121756 Genomic DNA. Translation: CAI22530.1.
RefSeqNP_777557.1. NM_174897.2.
UniGeneHs.375090.

3D structure databases

ProteinModelPortalQ8NFQ5.
SMRQ8NFQ5. Positions 18-453.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8NFQ5.

Polymorphism databases

DMDM34395537.

Proteomic databases

PaxDbQ8NFQ5.
PRIDEQ8NFQ5.

Protocols and materials databases

DNASU128859.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000349552; ENSP00000344929; ENSG00000167104.
GeneID128859.
KEGGhsa:128859.
UCSCuc010zuc.2. human.

Organism-specific databases

CTD128859.
GeneCardsGC20P031620.
HGNCHGNC:16504. BPIFB6.
HPAHPA043057.
MIM614110. gene.
neXtProtNX_Q8NFQ5.
PharmGKBPA25406.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG276086.
HOGENOMHOG000231740.
HOVERGENHBG095916.
InParanoidQ8NFQ5.
OMAKVTMKTG.
OrthoDBEOG7NW690.
PhylomeDBQ8NFQ5.
TreeFamTF315617.

Gene expression databases

ArrayExpressQ8NFQ5.
BgeeQ8NFQ5.
CleanExHS_BPIL3.
GenevestigatorQ8NFQ5.

Family and domain databases

InterProIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PfamPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMSSF55394. SSF55394. 2 hits.
ProtoNetSearch...

Other

GenomeRNAi128859.
NextBio82486.
PROQ8NFQ5.
SOURCESearch...

Entry information

Entry nameBPIB6_HUMAN
AccessionPrimary (citable) accession number: Q8NFQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: October 1, 2002
Last modified: March 19, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM