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Protein

BPI fold-containing family B member 6

Gene

BPIFB6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family B member 6
Alternative name(s):
Bactericidal/permeability-increasing protein-like 3
Gene namesi
Name:BPIFB6
Synonyms:BPIL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16504. BPIFB6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25406.

Polymorphism and mutation databases

BioMutaiBPIFB6.
DMDMi34395537.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 453435BPI fold-containing family B member 6PRO_0000017168Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi137 ↔ 174By similarity
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NFQ5.
PRIDEiQ8NFQ5.

PTM databases

PhosphoSiteiQ8NFQ5.

Expressioni

Tissue specificityi

Detected at very low levels in normal tonsils, and at higher levels in hypertrophic tonsils.

Gene expression databases

BgeeiQ8NFQ5.
CleanExiHS_BPIL3.
ExpressionAtlasiQ8NFQ5. baseline and differential.
GenevestigatoriQ8NFQ5.

Organism-specific databases

HPAiHPA043057.

Structurei

3D structure databases

ProteinModelPortaliQ8NFQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG276086.
GeneTreeiENSGT00730000110772.
HOGENOMiHOG000231740.
HOVERGENiHBG095916.
InParanoidiQ8NFQ5.
OMAiKVTMKTG.
OrthoDBiEOG7NW690.
PhylomeDBiQ8NFQ5.
TreeFamiTF315617.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NFQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRILCLALC SLLTGTRADP GALLRLGMDI MNQVQSAMDE SHILEKMAAE
60 70 80 90 100
AGKKQPGMKP IKGITNLKVK DVQLPVITLN FVPGVGIFQC VSTGMTVTGK
110 120 130 140 150
SFMGGNMEII VALNITATNR LLRDEETGLP VFKSEGCEVI LVNVKTNLPS
160 170 180 190 200
NMLPKMVNKF LDSTLHKVLP GLMCPAIDAV LVYVNRKWTN LSDPMPVGQM
210 220 230 240 250
GTVKYVLMSA PATTASYIQL DFSPVVQQQK GKTIKLADAG EALTFPEGYA
260 270 280 290 300
KGSSQLLLPA TFLSAELALL QKSFHVNIQD TMIGELPPQT TKTLARFIPE
310 320 330 340 350
VAVAYPKSKP LTTQIKIKKP PKVTMKTGKS LLHLHSTLEM FAARWRSKAP
360 370 380 390 400
MSLFLLEVHF NLKVQYSVHE NQLQMATSLD RLLSLSRKSS SIGNFNEREL
410 420 430 440 450
TGFITSYLEE AYIPVVNDVL QVGLPLPDFL AMNYNLAELD IVENALMLDL

KLG
Length:453
Mass (Da):49,717
Last modified:October 1, 2002 - v1
Checksum:i19379CA22A41CE5C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161T → M.
Corresponds to variant rs17301126 [ dbSNP | Ensembl ].
VAR_033632
Natural varianti97 – 971V → I.
Corresponds to variant rs2070317 [ dbSNP | Ensembl ].
VAR_024518
Natural varianti149 – 1491P → T.
Corresponds to variant rs11907355 [ dbSNP | Ensembl ].
VAR_033633
Natural varianti296 – 2961R → H De novo variant found in a patient with mental retardation. 1 Publication
Corresponds to variant rs79809934 [ dbSNP | Ensembl ].
VAR_065088
Natural varianti347 – 3471S → G.
Corresponds to variant rs4911287 [ dbSNP | Ensembl ].
VAR_033634

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465767 mRNA. Translation: AAM73985.1.
AL121756 Genomic DNA. Translation: CAI22530.1.
CCDSiCCDS13211.1.
RefSeqiNP_777557.1. NM_174897.2.
UniGeneiHs.375090.

Genome annotation databases

EnsembliENST00000349552; ENSP00000344929; ENSG00000167104.
GeneIDi128859.
KEGGihsa:128859.
UCSCiuc010zuc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465767 mRNA. Translation: AAM73985.1.
AL121756 Genomic DNA. Translation: CAI22530.1.
CCDSiCCDS13211.1.
RefSeqiNP_777557.1. NM_174897.2.
UniGeneiHs.375090.

3D structure databases

ProteinModelPortaliQ8NFQ5.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8NFQ5.

Polymorphism and mutation databases

BioMutaiBPIFB6.
DMDMi34395537.

Proteomic databases

PaxDbiQ8NFQ5.
PRIDEiQ8NFQ5.

Protocols and materials databases

DNASUi128859.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349552; ENSP00000344929; ENSG00000167104.
GeneIDi128859.
KEGGihsa:128859.
UCSCiuc010zuc.2. human.

Organism-specific databases

CTDi128859.
GeneCardsiGC20P031620.
HGNCiHGNC:16504. BPIFB6.
HPAiHPA043057.
MIMi614110. gene.
neXtProtiNX_Q8NFQ5.
PharmGKBiPA25406.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG276086.
GeneTreeiENSGT00730000110772.
HOGENOMiHOG000231740.
HOVERGENiHBG095916.
InParanoidiQ8NFQ5.
OMAiKVTMKTG.
OrthoDBiEOG7NW690.
PhylomeDBiQ8NFQ5.
TreeFamiTF315617.

Miscellaneous databases

GenomeRNAii128859.
NextBioi82486.
PROiQ8NFQ5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NFQ5.
CleanExiHS_BPIL3.
ExpressionAtlasiQ8NFQ5. baseline and differential.
GenevestigatoriQ8NFQ5.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP)."
    Mulero J.J., Boyle B.J., Bradley S., Bright J.M., Nelken S.T., Ho T.T., Mize N.K., Childs J.D., Ballinger D.G., Ford J.E., Rupp F.
    Immunogenetics 54:293-300(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Tonsil.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  4. Cited for: VARIANT HIS-296.

Entry informationi

Entry nameiBPIB6_HUMAN
AccessioniPrimary (citable) accession number: Q8NFQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: October 1, 2002
Last modified: April 29, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.