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Q8NFQ5

- BPIB6_HUMAN

UniProt

Q8NFQ5 - BPIB6_HUMAN

Protein

BPI fold-containing family B member 6

Gene

BPIFB6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. lipid binding Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BPI fold-containing family B member 6
    Alternative name(s):
    Bactericidal/permeability-increasing protein-like 3
    Gene namesi
    Name:BPIFB6
    Synonyms:BPIL3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:16504. BPIFB6.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25406.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 453435BPI fold-containing family B member 6PRO_0000017168Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi137 ↔ 174By similarity
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NFQ5.
    PRIDEiQ8NFQ5.

    PTM databases

    PhosphoSiteiQ8NFQ5.

    Expressioni

    Tissue specificityi

    Detected at very low levels in normal tonsils, and at higher levels in hypertrophic tonsils.

    Gene expression databases

    ArrayExpressiQ8NFQ5.
    BgeeiQ8NFQ5.
    CleanExiHS_BPIL3.
    GenevestigatoriQ8NFQ5.

    Organism-specific databases

    HPAiHPA043057.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NFQ5.
    SMRiQ8NFQ5. Positions 18-453.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG276086.
    HOGENOMiHOG000231740.
    HOVERGENiHBG095916.
    InParanoidiQ8NFQ5.
    OMAiKVTMKTG.
    OrthoDBiEOG7NW690.
    PhylomeDBiQ8NFQ5.
    TreeFamiTF315617.

    Family and domain databases

    InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
    IPR001124. Lipid-bd_serum_glycop_C.
    IPR017942. Lipid-bd_serum_glycop_N.
    [Graphical view]
    PfamiPF01273. LBP_BPI_CETP. 1 hit.
    PF02886. LBP_BPI_CETP_C. 1 hit.
    [Graphical view]
    SMARTiSM00328. BPI1. 1 hit.
    SM00329. BPI2. 1 hit.
    [Graphical view]
    SUPFAMiSSF55394. SSF55394. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8NFQ5-1 [UniParc]FASTAAdd to Basket

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    MLRILCLALC SLLTGTRADP GALLRLGMDI MNQVQSAMDE SHILEKMAAE    50
    AGKKQPGMKP IKGITNLKVK DVQLPVITLN FVPGVGIFQC VSTGMTVTGK 100
    SFMGGNMEII VALNITATNR LLRDEETGLP VFKSEGCEVI LVNVKTNLPS 150
    NMLPKMVNKF LDSTLHKVLP GLMCPAIDAV LVYVNRKWTN LSDPMPVGQM 200
    GTVKYVLMSA PATTASYIQL DFSPVVQQQK GKTIKLADAG EALTFPEGYA 250
    KGSSQLLLPA TFLSAELALL QKSFHVNIQD TMIGELPPQT TKTLARFIPE 300
    VAVAYPKSKP LTTQIKIKKP PKVTMKTGKS LLHLHSTLEM FAARWRSKAP 350
    MSLFLLEVHF NLKVQYSVHE NQLQMATSLD RLLSLSRKSS SIGNFNEREL 400
    TGFITSYLEE AYIPVVNDVL QVGLPLPDFL AMNYNLAELD IVENALMLDL 450
    KLG 453
    Length:453
    Mass (Da):49,717
    Last modified:October 1, 2002 - v1
    Checksum:i19379CA22A41CE5C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti16 – 161T → M.
    Corresponds to variant rs17301126 [ dbSNP | Ensembl ].
    VAR_033632
    Natural varianti97 – 971V → I.
    Corresponds to variant rs2070317 [ dbSNP | Ensembl ].
    VAR_024518
    Natural varianti149 – 1491P → T.
    Corresponds to variant rs11907355 [ dbSNP | Ensembl ].
    VAR_033633
    Natural varianti296 – 2961R → H De novo variant found in a patient with mental retardation. 1 Publication
    Corresponds to variant rs79809934 [ dbSNP | Ensembl ].
    VAR_065088
    Natural varianti347 – 3471S → G.
    Corresponds to variant rs4911287 [ dbSNP | Ensembl ].
    VAR_033634

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF465767 mRNA. Translation: AAM73985.1.
    AL121756 Genomic DNA. Translation: CAI22530.1.
    CCDSiCCDS13211.1.
    RefSeqiNP_777557.1. NM_174897.2.
    UniGeneiHs.375090.

    Genome annotation databases

    EnsembliENST00000349552; ENSP00000344929; ENSG00000167104.
    GeneIDi128859.
    KEGGihsa:128859.
    UCSCiuc010zuc.2. human.

    Polymorphism databases

    DMDMi34395537.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF465767 mRNA. Translation: AAM73985.1 .
    AL121756 Genomic DNA. Translation: CAI22530.1 .
    CCDSi CCDS13211.1.
    RefSeqi NP_777557.1. NM_174897.2.
    UniGenei Hs.375090.

    3D structure databases

    ProteinModelPortali Q8NFQ5.
    SMRi Q8NFQ5. Positions 18-453.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8NFQ5.

    Polymorphism databases

    DMDMi 34395537.

    Proteomic databases

    PaxDbi Q8NFQ5.
    PRIDEi Q8NFQ5.

    Protocols and materials databases

    DNASUi 128859.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000349552 ; ENSP00000344929 ; ENSG00000167104 .
    GeneIDi 128859.
    KEGGi hsa:128859.
    UCSCi uc010zuc.2. human.

    Organism-specific databases

    CTDi 128859.
    GeneCardsi GC20P031620.
    HGNCi HGNC:16504. BPIFB6.
    HPAi HPA043057.
    MIMi 614110. gene.
    neXtProti NX_Q8NFQ5.
    PharmGKBi PA25406.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG276086.
    HOGENOMi HOG000231740.
    HOVERGENi HBG095916.
    InParanoidi Q8NFQ5.
    OMAi KVTMKTG.
    OrthoDBi EOG7NW690.
    PhylomeDBi Q8NFQ5.
    TreeFami TF315617.

    Miscellaneous databases

    GenomeRNAii 128859.
    NextBioi 82486.
    PROi Q8NFQ5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NFQ5.
    Bgeei Q8NFQ5.
    CleanExi HS_BPIL3.
    Genevestigatori Q8NFQ5.

    Family and domain databases

    InterProi IPR017943. Bactericidal_perm-incr_a/b_dom.
    IPR001124. Lipid-bd_serum_glycop_C.
    IPR017942. Lipid-bd_serum_glycop_N.
    [Graphical view ]
    Pfami PF01273. LBP_BPI_CETP. 1 hit.
    PF02886. LBP_BPI_CETP_C. 1 hit.
    [Graphical view ]
    SMARTi SM00328. BPI1. 1 hit.
    SM00329. BPI2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55394. SSF55394. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP)."
      Mulero J.J., Boyle B.J., Bradley S., Bright J.M., Nelken S.T., Ho T.T., Mize N.K., Childs J.D., Ballinger D.G., Ford J.E., Rupp F.
      Immunogenetics 54:293-300(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Tonsil.
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    4. Cited for: VARIANT HIS-296.

    Entry informationi

    Entry nameiBPIB6_HUMAN
    AccessioniPrimary (citable) accession number: Q8NFQ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3