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Q8NFP9

- NBEA_HUMAN

UniProt

Q8NFP9 - NBEA_HUMAN

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Protein

Neurobeachin

Gene

NBEA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity).By similarity

GO - Biological processi

  1. protein localization Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ8NFP9.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurobeachin
Alternative name(s):
Lysosomal-trafficking regulator 2
Protein BCL8B
Gene namesi
Name:NBEA
Synonyms:BCL8B, KIAA1544, LYST2
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:7648. NBEA.

Subcellular locationi

Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. endomembrane system Source: UniProtKB
  3. plasma membrane Source: UniProtKB
  4. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31454.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 29462946NeurobeachinPRO_0000051089Add
BLAST

Proteomic databases

MaxQBiQ8NFP9.
PRIDEiQ8NFP9.

PTM databases

PhosphoSiteiQ8NFP9.

Expressioni

Tissue specificityi

Predominant in many brain structures. Also expressed at medium levels in spleen, thymus, prostate, testis and ovary. Low level expression is seen in heart, kidney, pancreas, skeletal muscle and intestine.1 Publication

Gene expression databases

BgeeiQ8NFP9.
CleanExiHS_NBEA.
ExpressionAtlasiQ8NFP9. baseline and differential.
GenevestigatoriQ8NFP9.

Organism-specific databases

HPAiHPA039730.
HPA040385.

Interactioni

Subunit structurei

Interacts with RII subunit of PKA.By similarity

Protein-protein interaction databases

BioGridi117928. 8 interactions.
IntActiQ8NFP9. 6 interactions.
MINTiMINT-1380608.
STRINGi9606.ENSP00000383295.

Structurei

Secondary structure

1
2946
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2154 – 21629Combined sources
Beta strandi2165 – 21739Combined sources
Beta strandi2175 – 21828Combined sources
Helixi2187 – 21904Combined sources
Helixi2194 – 21996Combined sources
Beta strandi2206 – 22083Combined sources
Helixi2209 – 22113Combined sources
Beta strandi2212 – 22209Combined sources
Beta strandi2223 – 22319Combined sources
Beta strandi2236 – 22405Combined sources
Helixi2244 – 22529Combined sources
Helixi2269 – 22735Combined sources
Helixi2276 – 22816Combined sources
Helixi2285 – 22906Combined sources
Helixi2296 – 230611Combined sources
Helixi2314 – 23163Combined sources
Beta strandi2328 – 23314Combined sources
Helixi2337 – 23393Combined sources
Helixi2347 – 23493Combined sources
Helixi2352 – 236312Combined sources
Beta strandi2374 – 23774Combined sources
Helixi2382 – 23887Combined sources
Turni2389 – 23913Combined sources
Helixi2395 – 24017Combined sources
Turni2402 – 24054Combined sources
Turni2410 – 24123Combined sources
Helixi2417 – 242610Combined sources
Helixi2436 – 24394Combined sources
Helixi2442 – 24454Combined sources
Helixi2474 – 248512Combined sources
Helixi2488 – 24914Combined sources
Helixi2494 – 25018Combined sources
Beta strandi2506 – 25083Combined sources
Helixi2509 – 25135Combined sources
Turni2520 – 25223Combined sources
Turni2529 – 25313Combined sources
Helixi2535 – 254814Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MI1X-ray2.90A/B2150-2563[»]
ProteinModelPortaliQ8NFP9.
SMRiQ8NFP9. Positions 2150-2563, 2692-2900.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NFP9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1326 – 136843WD 1CuratedAdd
BLAST
Domaini2274 – 2563290BEACHCuratedPROSITE-ProRule annotationAdd
BLAST
Repeati2718 – 276144WD 2CuratedAdd
BLAST
Repeati2778 – 281841WD 3CuratedAdd
BLAST
Repeati2860 – 289940WD 4CuratedAdd
BLAST
Repeati2902 – 294140WD 5CuratedAdd
BLAST

Domaini

RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.By similarity

Sequence similaritiesi

Belongs to the WD repeat neurobeachin family.Curated
Contains 1 BEACH domain.CuratedPROSITE-ProRule annotation
Contains 5 WD repeats.CuratedPROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00760000119083.
HOGENOMiHOG000082375.
HOVERGENiHBG012582.
InParanoidiQ8NFP9.
PhylomeDBiQ8NFP9.
TreeFamiTF313490.

Family and domain databases

Gene3Di1.10.1540.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.40. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000409. BEACH_dom.
IPR013320. ConA-like_dom.
IPR010508. DUF1088.
IPR023362. PH-BEACH_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF02138. Beach. 1 hit.
PF06469. DUF1088. 1 hit.
PF14844. PH_BEACH. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM01026. Beach. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEiPS50197. BEACH. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1Curated (identifier: Q8NFP9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASEKPGPGP GLEPQPVGLI AVGAAGGGGG GSGGGGTGGS GMGELRGASG
60 70 80 90 100
SGSVMLPAGM INPSVPIRNI RMKFAVLIGL IQVGEVSNRD IVETVLNLLV
110 120 130 140 150
GGEFDLEMNF IIQDAESITC MTELLEHCDV TCQAEIWSMF TAILRKSVRN
160 170 180 190 200
LQTSTEVGLI EQVLLKMSAV DDMIADLLVD MLGVLASYSI TVKELKLLFS
210 220 230 240 250
MLRGESGIWP RHAVKLLSVL NQMPQRHGPD TFFNFPGCSA AAIALPPIAK
260 270 280 290 300
WPYQNGFTLN TWFRMDPLNN INVDKDKPYL YCFRTSKGVG YSAHFVGNCL
310 320 330 340 350
IVTSLKSKGK GFQHCVKYDF QPRKWYMISI VHIYNRWRNS EIRCYVNGQL
360 370 380 390 400
VSYGDMAWHV NTNDSYDKCF LGSSETADAN RVFCGQLGAV YVFSEALNPA
410 420 430 440 450
QIFAIHQLGP GYKSTFKFKS ESDIHLAEHH KQVLYDGKLA SSIAFTYNAK
460 470 480 490 500
ATDAQLCLES SPKENASIFV HSPHALMLQD VKAIVTHSIH SAIHSIGGIQ
510 520 530 540 550
VLFPLFAQLD NRQLNDSQVE TTVCATLLAF LVELLKSSVA MQEQMLGGKG
560 570 580 590 600
FLVIGYLLEK SSRVHITRAV LEQFLSFAKY LDGLSHGAPL LKQLCDHILF
610 620 630 640 650
NPAIWIHTPA KVQLSLYTYL SAEFIGTATI YTTIRRVGTV LQLMHTLKYY
660 670 680 690 700
YWVINPADSS GITPKGLDGP RPSQKEIISL RAFMLLFLKQ LILKDRGVKE
710 720 730 740 750
DELQSILNYL LTMHEDENIH DVLQLLVALM SEHPASMIPA FDQRNGIRVI
760 770 780 790 800
YKLLASKSES IWVQALKVLG YFLKHLGHKR KVEIMHTHSL FTLLGERLML
810 820 830 840 850
HTNTVTVTTY NTLYEILTEQ VCTQVVHKPH PEPDSTVKIQ NPMILKVVAT
860 870 880 890 900
LLKNSTPSAE LMEVRRLFLS DMIKLFSNSR ENRRCLLQCS VWQDWMFSLG
910 920 930 940 950
YINPKNSEEQ KITEMVYNIF RILLYHAIKY EWGGWRVWVD TLSIAHSKVT
960 970 980 990 1000
YEAHKEYLAK MYEEYQRQEE ENIKKGKKGN VSTISGLSSQ TTGAKGGMEI
1010 1020 1030 1040 1050
REIEDLSQSQ SPESETDYPV STDTRDLLMS TKVSDDILGN SDRPGSGVHV
1060 1070 1080 1090 1100
EVHDLLVDIK AEKVEATEVK LDDMDLSPET LVGGENGALV EVESLLDNVY
1110 1120 1130 1140 1150
SAAVEKLQNN VHGSVGIIKK NEEKDNGPLI TLADEKEDLP NSSTSFLFDK
1160 1170 1180 1190 1200
IPKQEEKLLP ELSSNHIIPN IQDTQVHLGV SDDLGLLAHM TGSVDLTCTS
1210 1220 1230 1240 1250
SIIEEKEFKI HTTSDGMSSI SERDLASSTK GLEYAEMTAT TLETESSSSK
1260 1270 1280 1290 1300
IVPNIDAGSI ISDTERSDDG KESGKEIRKI QTTTTTQAVQ GRSITQQDRD
1310 1320 1330 1340 1350
LRVDLGFRGM PMTEEQRRQF SPGPRTTMFR IPEFKWSPMH QRLLTDLLFA
1360 1370 1380 1390 1400
LETDVHVWRS HSTKSVMDFV NSNENIIFVH NTIHLISQMV DNIIIACGGI
1410 1420 1430 1440 1450
LPLLSAATSP TGSKTELENI EVTQGMSAET AVTFLSRLMA MVDVLVFASS
1460 1470 1480 1490 1500
LNFSEIEAEK NMSSGGLMRQ CLRLVCCVAV RNCLECRQRQ RDRGNKSSHG
1510 1520 1530 1540 1550
SSKPQEVPQS VTATAASKTP LENVPGNLSP IKDPDRLLQD VDINRLRAVV
1560 1570 1580 1590 1600
FRDVDDSKQA QFLALAVVYF ISVLMVSKYR DILEPQRETT RTGSQPGRNI
1610 1620 1630 1640 1650
RQEINSPTST VVVIPSIPHP SLNHGFLAKL IPEQSFGHSF YKETPAAFPD
1660 1670 1680 1690 1700
TIKEKETPTP GEDIQVESSI PHTDSGIGEE QVASILNGAE LETSTGPDAM
1710 1720 1730 1740 1750
SELLSTLSSE VKKSQESLTE NPSETLKPAT SISSISQTKG INVKEILKSL
1760 1770 1780 1790 1800
VAAPVEIAEC GPEPIPYPDP ALKRETQAIL PMQFHSFDRS VVVPVKKPPP
1810 1820 1830 1840 1850
GSLAVTTVGA TTAGSGLPTG STSNIFAATG ATPKSMINTT GAVDSGSSSS
1860 1870 1880 1890 1900
SSSSSFVNGA TSKNLPAVQT VAPMPEDSAE NMSITAKLER ALEKVAPLLR
1910 1920 1930 1940 1950
EIFVDFAPFL SRTLLGSHGQ ELLIEGLVCM KSSTSVVELV MLLCSQEWQN
1960 1970 1980 1990 2000
SIQKNAGLAF IELINEGRLL CHAMKDHIVR VANEAEFILN RQRAEDVHKH
2010 2020 2030 2040 2050
AEFESQCAQY AADRREEEKM CDHLISAAKH RDHVTANQLK QKILNILTNK
2060 2070 2080 2090 2100
HGAWGAVSHS QLHDFWRLDY WEDDLRRRRR FVRNAFGSTH AEALLKAAIE
2110 2120 2130 2140 2150
YGTEEDVVKS KKTFRSQAIV NQNAETELML EGDDDAVSLL QEKEIDNLAG
2160 2170 2180 2190 2200
PVVLSTPAQL IAPVVVAKGT LSITTTEIYF EVDEDDSAFK KIDTKVLAYT
2210 2220 2230 2240 2250
EGLHGKWMFS EIRAVFSRRY LLQNTALEVF MANRTSVMFN FPDQATVKKV
2260 2270 2280 2290 2300
VYSLPRVGVG TSYGLPQARR ISLATPRQLY KSSNMTQRWQ RREISNFEYL
2310 2320 2330 2340 2350
MFLNTIAGRT YNDLNQYPVF PWVLTNYESE ELDLTLPGNF RDLSKPIGAL
2360 2370 2380 2390 2400
NPKRAVFYAE RYETWEDDQS PPYHYNTHYS TATSTLSWLV RIEPFTTFFL
2410 2420 2430 2440 2450
NANDGKFDHP DRTFSSVARS WRTSQRDTSD VKELIPEFYY LPEMFVNSNG
2460 2470 2480 2490 2500
YNLGVREDEV VVNDVDLPPW AKKPEDFVRI NRMALESEFV SCQLHQWIDL
2510 2520 2530 2540 2550
IFGYKQRGPE AVRALNVFHY LTYEGSVNLD SITDPVLREA MEAQIQNFGQ
2560 2570 2580 2590 2600
TPSQLLIEPH PPRSSAMHLC FLPQSPLMFK DQMQQDVIMV LKFPSNSPVT
2610 2620 2630 2640 2650
HVAANTLPHL TIPAVVTVTC SRLFAVNRWH NTVGLRGAPG YSLDQAHHLP
2660 2670 2680 2690 2700
IEMDPLIANN SGVNKRQITD LVDQSIQINA HCFVVTADNR YILICGFWDK
2710 2720 2730 2740 2750
SFRVYSTETG KLTQIVFGHW DVVTCLARSE SYIGGDCYIV SGSRDATLLL
2760 2770 2780 2790 2800
WYWSGRHHII GDNPNSSDYP APRAVLTGHD HEVVCVSVCA ELGLVISGAK
2810 2820 2830 2840 2850
EGPCLVHTIT GDLLRALEGP ENCLFPRLIS VSSEGHCIIY YERGRFSNFS
2860 2870 2880 2890 2900
INGKLLAQME INDSTRAILL SSDGQNLVTG GDNGVVEVWQ ACDFKQLYIY
2910 2920 2930 2940
PGCDAGIRAM DLSHDQRTLI TGMASGSIVA FNIDFNRWHY EHQNRY
Length:2,946
Mass (Da):327,822
Last modified:May 18, 2010 - v3
Checksum:i2E371FDA2F00781E
GO
Isoform 2Curated (identifier: Q8NFP9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2443: Missing.
     2539-2539: E → EIPEAYFIRDPHTFLLTKDFIK

Note: No experimental confirmation available.Curated

Show »
Length:524
Mass (Da):58,802
Checksum:iF4A38C3EFE58D390
GO
Isoform 3 (identifier: Q8NFP9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2207: Missing.

Note: No experimental confirmation available.

Show »
Length:739
Mass (Da):84,001
Checksum:i38BA7126B5FFBBE7
GO

Sequence cautioni

The sequence AAD41633.1 differs from that shown. Reason: Frameshift at position 2900. Curated
The sequence BAA91485.1 differs from that shown. Reason: Erroneous termination at position 762. Translated as Trp.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1658 – 16581P → S in AAM53531. (PubMed:12160729)Curated
Sequence conflicti2564 – 25641S → N in AAD41633. 1 PublicationCurated
Sequence conflicti2706 – 27061S → T in AAD41633. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti569 – 5691A → P.
Corresponds to variant rs5011295 [ dbSNP | Ensembl ].
VAR_047658
Natural varianti2501 – 25011I → V.
Corresponds to variant rs11538677 [ dbSNP | Ensembl ].
VAR_047659

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 24432443Missing in isoform 2. 1 PublicationVSP_050538Add
BLAST
Alternative sequencei1 – 22072207Missing in isoform 3. 1 PublicationVSP_046397Add
BLAST
Alternative sequencei2539 – 25391E → EIPEAYFIRDPHTFLLTKDF IK in isoform 2. 1 PublicationVSP_050539

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF467288 mRNA. Translation: AAM53531.1.
AL138690 Genomic DNA. No translation available.
AK001059 mRNA. Translation: BAA91485.1. Sequence problems.
AK294737 mRNA. Translation: BAH11865.1.
AL139083, AL390071 Genomic DNA. Translation: CAH71883.1.
AL159160 Genomic DNA. No translation available.
AL161718 Genomic DNA. No translation available.
AL161902 Genomic DNA. No translation available.
AL356430 Genomic DNA. No translation available.
AL357083 Genomic DNA. No translation available.
AL390071, AL139083 Genomic DNA. Translation: CAI17183.1.
AB046764 mRNA. Translation: BAB13370.1.
AL137748 mRNA. Translation: CAB70903.2.
AF072371 mRNA. Translation: AAD41633.1. Frameshift.
CCDSiCCDS45026.1. [Q8NFP9-1]
CCDS55894.1. [Q8NFP9-3]
PIRiT46310.
RefSeqiNP_001191126.1. NM_001204197.1. [Q8NFP9-3]
NP_056493.3. NM_015678.4. [Q8NFP9-1]
UniGeneiHs.491172.

Genome annotation databases

GeneIDi26960.
KEGGihsa:26960.
UCSCiuc001uvd.3. human. [Q8NFP9-2]
uc010tee.1. human.
uc021ric.1. human. [Q8NFP9-1]

Polymorphism databases

DMDMi296439289.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF467288 mRNA. Translation: AAM53531.1 .
AL138690 Genomic DNA. No translation available.
AK001059 mRNA. Translation: BAA91485.1 . Sequence problems.
AK294737 mRNA. Translation: BAH11865.1 .
AL139083 , AL390071 Genomic DNA. Translation: CAH71883.1 .
AL159160 Genomic DNA. No translation available.
AL161718 Genomic DNA. No translation available.
AL161902 Genomic DNA. No translation available.
AL356430 Genomic DNA. No translation available.
AL357083 Genomic DNA. No translation available.
AL390071 , AL139083 Genomic DNA. Translation: CAI17183.1 .
AB046764 mRNA. Translation: BAB13370.1 .
AL137748 mRNA. Translation: CAB70903.2 .
AF072371 mRNA. Translation: AAD41633.1 . Frameshift.
CCDSi CCDS45026.1. [Q8NFP9-1 ]
CCDS55894.1. [Q8NFP9-3 ]
PIRi T46310.
RefSeqi NP_001191126.1. NM_001204197.1. [Q8NFP9-3 ]
NP_056493.3. NM_015678.4. [Q8NFP9-1 ]
UniGenei Hs.491172.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1MI1 X-ray 2.90 A/B 2150-2563 [» ]
ProteinModelPortali Q8NFP9.
SMRi Q8NFP9. Positions 2150-2563, 2692-2900.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117928. 8 interactions.
IntActi Q8NFP9. 6 interactions.
MINTi MINT-1380608.
STRINGi 9606.ENSP00000383295.

PTM databases

PhosphoSitei Q8NFP9.

Polymorphism databases

DMDMi 296439289.

Proteomic databases

MaxQBi Q8NFP9.
PRIDEi Q8NFP9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 26960.
KEGGi hsa:26960.
UCSCi uc001uvd.3. human. [Q8NFP9-2 ]
uc010tee.1. human.
uc021ric.1. human. [Q8NFP9-1 ]

Organism-specific databases

CTDi 26960.
GeneCardsi GC13P035516.
H-InvDB HIX0029795.
HGNCi HGNC:7648. NBEA.
HPAi HPA039730.
HPA040385.
MIMi 604889. gene.
neXtProti NX_Q8NFP9.
PharmGKBi PA31454.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000119083.
HOGENOMi HOG000082375.
HOVERGENi HBG012582.
InParanoidi Q8NFP9.
PhylomeDBi Q8NFP9.
TreeFami TF313490.

Enzyme and pathway databases

SignaLinki Q8NFP9.

Miscellaneous databases

ChiTaRSi NBEA. human.
EvolutionaryTracei Q8NFP9.
GenomeRNAii 26960.
NextBioi 49420.
PROi Q8NFP9.
SOURCEi Search...

Gene expression databases

Bgeei Q8NFP9.
CleanExi HS_NBEA.
ExpressionAtlasi Q8NFP9. baseline and differential.
Genevestigatori Q8NFP9.

Family and domain databases

Gene3Di 1.10.1540.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.40. 1 hit.
2.60.120.200. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR000409. BEACH_dom.
IPR013320. ConA-like_dom.
IPR010508. DUF1088.
IPR023362. PH-BEACH_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF02138. Beach. 1 hit.
PF06469. DUF1088. 1 hit.
PF14844. PH_BEACH. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM01026. Beach. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEi PS50197. BEACH. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "BCL8 is a novel, evolutionarily conserved human gene family encoding proteins with presumptive protein kinase A anchoring function."
    Dyomin V.G., Chaganti S.R., Dyomina K., Palanisamy N., Murty V.V.V.S., Dalla-Favera R., Chaganti R.S.K.
    Genomics 80:158-165(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Brain1 Publication and Spleen1 Publication.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 606-1118 (ISOFORMS 1/2).
    Tissue: Brain and Embryonic head.
  3. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1919-2946 (ISOFORM 1).
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2393-2946 (ISOFORM 2).
    Tissue: Testis.
  6. "Identification of LYST2, a brain-specific member of the Chediak-Higashi syndrome gene family."
    Tchernev V.T., McMurtrie E.B., Nguyen Q.A., Mishra V.S., Barbosa M.D.F.S., McIndoe R., Kingsmore S.F.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2428-2946 (ISOFORM 1).
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain."
    Jogl G., Shen Y., Gebauer D., Li J., Wiegmann K., Kashkar H., Kroenke M., Tong L.
    EMBO J. 21:4785-4795(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 2150-2563.

Entry informationi

Entry nameiNBEA_HUMAN
AccessioniPrimary (citable) accession number: Q8NFP9
Secondary accession number(s): B7Z2H9
, Q5T320, Q9HCM8, Q9NSU1, Q9NW98, Q9Y6J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: May 18, 2010
Last modified: November 26, 2014
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3