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Protein

Neurobeachin

Gene

NBEA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172915-MONOMER.
SignaLinkiQ8NFP9.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurobeachin
Alternative name(s):
Lysosomal-trafficking regulator 2
Protein BCL8B
Gene namesi
Name:NBEA
Synonyms:BCL8B, KIAA1544, LYST2
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:7648. NBEA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26960.
OpenTargetsiENSG00000172915.
PharmGKBiPA31454.

Polymorphism and mutation databases

BioMutaiNBEA.
DMDMi296439289.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510891 – 2946NeurobeachinAdd BLAST2946

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1011PhosphoserineBy similarity1
Modified residuei1014PhosphoserineBy similarity1
Modified residuei1529PhosphoserineBy similarity1
Modified residuei1714PhosphoserineBy similarity1
Modified residuei1717PhosphoserineBy similarity1
Modified residuei2138PhosphoserineBy similarity1
Modified residuei2575PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8NFP9.
MaxQBiQ8NFP9.
PaxDbiQ8NFP9.
PeptideAtlasiQ8NFP9.
PRIDEiQ8NFP9.

PTM databases

iPTMnetiQ8NFP9.
PhosphoSitePlusiQ8NFP9.

Expressioni

Tissue specificityi

Predominant in many brain structures. Also expressed at medium levels in spleen, thymus, prostate, testis and ovary. Low level expression is seen in heart, kidney, pancreas, skeletal muscle and intestine.1 Publication

Gene expression databases

BgeeiENSG00000172915.
CleanExiHS_NBEA.
ExpressionAtlasiQ8NFP9. baseline and differential.
GenevisibleiQ8NFP9. HS.

Organism-specific databases

HPAiHPA039730.
HPA040385.

Interactioni

Subunit structurei

Interacts with RII subunit of PKA.By similarity

Protein-protein interaction databases

BioGridi117928. 13 interactors.
IntActiQ8NFP9. 7 interactors.
MINTiMINT-1380608.
STRINGi9606.ENSP00000383295.

Structurei

Secondary structure

12946
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2154 – 2162Combined sources9
Beta strandi2165 – 2173Combined sources9
Beta strandi2175 – 2182Combined sources8
Helixi2187 – 2190Combined sources4
Helixi2194 – 2199Combined sources6
Beta strandi2206 – 2208Combined sources3
Helixi2209 – 2211Combined sources3
Beta strandi2212 – 2220Combined sources9
Beta strandi2223 – 2231Combined sources9
Beta strandi2236 – 2240Combined sources5
Helixi2244 – 2252Combined sources9
Helixi2269 – 2273Combined sources5
Helixi2276 – 2281Combined sources6
Helixi2285 – 2290Combined sources6
Helixi2296 – 2306Combined sources11
Helixi2314 – 2316Combined sources3
Beta strandi2328 – 2331Combined sources4
Helixi2337 – 2339Combined sources3
Helixi2347 – 2349Combined sources3
Helixi2352 – 2363Combined sources12
Beta strandi2374 – 2377Combined sources4
Helixi2382 – 2388Combined sources7
Turni2389 – 2391Combined sources3
Helixi2395 – 2401Combined sources7
Turni2402 – 2405Combined sources4
Turni2410 – 2412Combined sources3
Helixi2417 – 2426Combined sources10
Helixi2436 – 2439Combined sources4
Helixi2442 – 2445Combined sources4
Helixi2474 – 2485Combined sources12
Helixi2488 – 2491Combined sources4
Helixi2494 – 2501Combined sources8
Beta strandi2506 – 2508Combined sources3
Helixi2509 – 2513Combined sources5
Turni2520 – 2522Combined sources3
Turni2529 – 2531Combined sources3
Helixi2535 – 2548Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MI1X-ray2.90A/B2150-2563[»]
ProteinModelPortaliQ8NFP9.
SMRiQ8NFP9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NFP9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1326 – 1368WD 1CuratedAdd BLAST43
Domaini2147 – 2255BEACH-type PHPROSITE-ProRule annotationAdd BLAST109
Domaini2274 – 2563BEACHPROSITE-ProRule annotationCuratedAdd BLAST290
Repeati2718 – 2761WD 2CuratedAdd BLAST44
Repeati2778 – 2818WD 3CuratedAdd BLAST41
Repeati2860 – 2899WD 4CuratedAdd BLAST40
Repeati2902 – 2941WD 5CuratedAdd BLAST40

Domaini

RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.By similarity

Sequence similaritiesi

Belongs to the WD repeat neurobeachin family.Curated
Contains 1 BEACH domain.PROSITE-ProRule annotationCurated
Contains 1 BEACH-type PH domain.PROSITE-ProRule annotation
Contains 5 WD repeats.PROSITE-ProRule annotationCurated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1786. Eukaryota.
ENOG410XNQC. LUCA.
GeneTreeiENSGT00760000119083.
HOGENOMiHOG000082375.
HOVERGENiHBG012582.
InParanoidiQ8NFP9.
PhylomeDBiQ8NFP9.
TreeFamiTF313490.

Family and domain databases

CDDicd06071. Beach. 1 hit.
Gene3Di1.10.1540.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.40. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000409. BEACH_dom.
IPR013320. ConA-like_dom.
IPR010508. DUF1088.
IPR031570. DUF4704.
IPR023362. PH-BEACH_dom.
IPR011993. PH_dom-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF02138. Beach. 1 hit.
PF06469. DUF1088. 1 hit.
PF15787. DUF4704. 1 hit.
PF14844. PH_BEACH. 1 hit.
[Graphical view]
SMARTiSM01026. Beach. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEiPS50197. BEACH. 1 hit.
PS51783. PH_BEACH. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1Curated (identifier: Q8NFP9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASEKPGPGP GLEPQPVGLI AVGAAGGGGG GSGGGGTGGS GMGELRGASG
60 70 80 90 100
SGSVMLPAGM INPSVPIRNI RMKFAVLIGL IQVGEVSNRD IVETVLNLLV
110 120 130 140 150
GGEFDLEMNF IIQDAESITC MTELLEHCDV TCQAEIWSMF TAILRKSVRN
160 170 180 190 200
LQTSTEVGLI EQVLLKMSAV DDMIADLLVD MLGVLASYSI TVKELKLLFS
210 220 230 240 250
MLRGESGIWP RHAVKLLSVL NQMPQRHGPD TFFNFPGCSA AAIALPPIAK
260 270 280 290 300
WPYQNGFTLN TWFRMDPLNN INVDKDKPYL YCFRTSKGVG YSAHFVGNCL
310 320 330 340 350
IVTSLKSKGK GFQHCVKYDF QPRKWYMISI VHIYNRWRNS EIRCYVNGQL
360 370 380 390 400
VSYGDMAWHV NTNDSYDKCF LGSSETADAN RVFCGQLGAV YVFSEALNPA
410 420 430 440 450
QIFAIHQLGP GYKSTFKFKS ESDIHLAEHH KQVLYDGKLA SSIAFTYNAK
460 470 480 490 500
ATDAQLCLES SPKENASIFV HSPHALMLQD VKAIVTHSIH SAIHSIGGIQ
510 520 530 540 550
VLFPLFAQLD NRQLNDSQVE TTVCATLLAF LVELLKSSVA MQEQMLGGKG
560 570 580 590 600
FLVIGYLLEK SSRVHITRAV LEQFLSFAKY LDGLSHGAPL LKQLCDHILF
610 620 630 640 650
NPAIWIHTPA KVQLSLYTYL SAEFIGTATI YTTIRRVGTV LQLMHTLKYY
660 670 680 690 700
YWVINPADSS GITPKGLDGP RPSQKEIISL RAFMLLFLKQ LILKDRGVKE
710 720 730 740 750
DELQSILNYL LTMHEDENIH DVLQLLVALM SEHPASMIPA FDQRNGIRVI
760 770 780 790 800
YKLLASKSES IWVQALKVLG YFLKHLGHKR KVEIMHTHSL FTLLGERLML
810 820 830 840 850
HTNTVTVTTY NTLYEILTEQ VCTQVVHKPH PEPDSTVKIQ NPMILKVVAT
860 870 880 890 900
LLKNSTPSAE LMEVRRLFLS DMIKLFSNSR ENRRCLLQCS VWQDWMFSLG
910 920 930 940 950
YINPKNSEEQ KITEMVYNIF RILLYHAIKY EWGGWRVWVD TLSIAHSKVT
960 970 980 990 1000
YEAHKEYLAK MYEEYQRQEE ENIKKGKKGN VSTISGLSSQ TTGAKGGMEI
1010 1020 1030 1040 1050
REIEDLSQSQ SPESETDYPV STDTRDLLMS TKVSDDILGN SDRPGSGVHV
1060 1070 1080 1090 1100
EVHDLLVDIK AEKVEATEVK LDDMDLSPET LVGGENGALV EVESLLDNVY
1110 1120 1130 1140 1150
SAAVEKLQNN VHGSVGIIKK NEEKDNGPLI TLADEKEDLP NSSTSFLFDK
1160 1170 1180 1190 1200
IPKQEEKLLP ELSSNHIIPN IQDTQVHLGV SDDLGLLAHM TGSVDLTCTS
1210 1220 1230 1240 1250
SIIEEKEFKI HTTSDGMSSI SERDLASSTK GLEYAEMTAT TLETESSSSK
1260 1270 1280 1290 1300
IVPNIDAGSI ISDTERSDDG KESGKEIRKI QTTTTTQAVQ GRSITQQDRD
1310 1320 1330 1340 1350
LRVDLGFRGM PMTEEQRRQF SPGPRTTMFR IPEFKWSPMH QRLLTDLLFA
1360 1370 1380 1390 1400
LETDVHVWRS HSTKSVMDFV NSNENIIFVH NTIHLISQMV DNIIIACGGI
1410 1420 1430 1440 1450
LPLLSAATSP TGSKTELENI EVTQGMSAET AVTFLSRLMA MVDVLVFASS
1460 1470 1480 1490 1500
LNFSEIEAEK NMSSGGLMRQ CLRLVCCVAV RNCLECRQRQ RDRGNKSSHG
1510 1520 1530 1540 1550
SSKPQEVPQS VTATAASKTP LENVPGNLSP IKDPDRLLQD VDINRLRAVV
1560 1570 1580 1590 1600
FRDVDDSKQA QFLALAVVYF ISVLMVSKYR DILEPQRETT RTGSQPGRNI
1610 1620 1630 1640 1650
RQEINSPTST VVVIPSIPHP SLNHGFLAKL IPEQSFGHSF YKETPAAFPD
1660 1670 1680 1690 1700
TIKEKETPTP GEDIQVESSI PHTDSGIGEE QVASILNGAE LETSTGPDAM
1710 1720 1730 1740 1750
SELLSTLSSE VKKSQESLTE NPSETLKPAT SISSISQTKG INVKEILKSL
1760 1770 1780 1790 1800
VAAPVEIAEC GPEPIPYPDP ALKRETQAIL PMQFHSFDRS VVVPVKKPPP
1810 1820 1830 1840 1850
GSLAVTTVGA TTAGSGLPTG STSNIFAATG ATPKSMINTT GAVDSGSSSS
1860 1870 1880 1890 1900
SSSSSFVNGA TSKNLPAVQT VAPMPEDSAE NMSITAKLER ALEKVAPLLR
1910 1920 1930 1940 1950
EIFVDFAPFL SRTLLGSHGQ ELLIEGLVCM KSSTSVVELV MLLCSQEWQN
1960 1970 1980 1990 2000
SIQKNAGLAF IELINEGRLL CHAMKDHIVR VANEAEFILN RQRAEDVHKH
2010 2020 2030 2040 2050
AEFESQCAQY AADRREEEKM CDHLISAAKH RDHVTANQLK QKILNILTNK
2060 2070 2080 2090 2100
HGAWGAVSHS QLHDFWRLDY WEDDLRRRRR FVRNAFGSTH AEALLKAAIE
2110 2120 2130 2140 2150
YGTEEDVVKS KKTFRSQAIV NQNAETELML EGDDDAVSLL QEKEIDNLAG
2160 2170 2180 2190 2200
PVVLSTPAQL IAPVVVAKGT LSITTTEIYF EVDEDDSAFK KIDTKVLAYT
2210 2220 2230 2240 2250
EGLHGKWMFS EIRAVFSRRY LLQNTALEVF MANRTSVMFN FPDQATVKKV
2260 2270 2280 2290 2300
VYSLPRVGVG TSYGLPQARR ISLATPRQLY KSSNMTQRWQ RREISNFEYL
2310 2320 2330 2340 2350
MFLNTIAGRT YNDLNQYPVF PWVLTNYESE ELDLTLPGNF RDLSKPIGAL
2360 2370 2380 2390 2400
NPKRAVFYAE RYETWEDDQS PPYHYNTHYS TATSTLSWLV RIEPFTTFFL
2410 2420 2430 2440 2450
NANDGKFDHP DRTFSSVARS WRTSQRDTSD VKELIPEFYY LPEMFVNSNG
2460 2470 2480 2490 2500
YNLGVREDEV VVNDVDLPPW AKKPEDFVRI NRMALESEFV SCQLHQWIDL
2510 2520 2530 2540 2550
IFGYKQRGPE AVRALNVFHY LTYEGSVNLD SITDPVLREA MEAQIQNFGQ
2560 2570 2580 2590 2600
TPSQLLIEPH PPRSSAMHLC FLPQSPLMFK DQMQQDVIMV LKFPSNSPVT
2610 2620 2630 2640 2650
HVAANTLPHL TIPAVVTVTC SRLFAVNRWH NTVGLRGAPG YSLDQAHHLP
2660 2670 2680 2690 2700
IEMDPLIANN SGVNKRQITD LVDQSIQINA HCFVVTADNR YILICGFWDK
2710 2720 2730 2740 2750
SFRVYSTETG KLTQIVFGHW DVVTCLARSE SYIGGDCYIV SGSRDATLLL
2760 2770 2780 2790 2800
WYWSGRHHII GDNPNSSDYP APRAVLTGHD HEVVCVSVCA ELGLVISGAK
2810 2820 2830 2840 2850
EGPCLVHTIT GDLLRALEGP ENCLFPRLIS VSSEGHCIIY YERGRFSNFS
2860 2870 2880 2890 2900
INGKLLAQME INDSTRAILL SSDGQNLVTG GDNGVVEVWQ ACDFKQLYIY
2910 2920 2930 2940
PGCDAGIRAM DLSHDQRTLI TGMASGSIVA FNIDFNRWHY EHQNRY
Length:2,946
Mass (Da):327,822
Last modified:May 18, 2010 - v3
Checksum:i2E371FDA2F00781E
GO
Isoform 2Curated (identifier: Q8NFP9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2443: Missing.
     2539-2539: E → EIPEAYFIRDPHTFLLTKDFIK

Note: No experimental confirmation available.Curated
Show »
Length:524
Mass (Da):58,802
Checksum:iF4A38C3EFE58D390
GO
Isoform 3 (identifier: Q8NFP9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2207: Missing.

Note: No experimental confirmation available.
Show »
Length:739
Mass (Da):84,001
Checksum:i38BA7126B5FFBBE7
GO

Sequence cautioni

The sequence AAD41633 differs from that shown. Reason: Frameshift at position 2900.Curated
The sequence BAA91485 differs from that shown. Reason: Erroneous termination at position 762. Translated as Trp.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1658P → S in AAM53531 (PubMed:12160729).Curated1
Sequence conflicti2564S → N in AAD41633 (Ref. 6) Curated1
Sequence conflicti2706S → T in AAD41633 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047658569A → P.Corresponds to variant rs5011295dbSNPEnsembl.1
Natural variantiVAR_0476592501I → V.Corresponds to variant rs11538677dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0505381 – 2443Missing in isoform 2. 1 PublicationAdd BLAST2443
Alternative sequenceiVSP_0463971 – 2207Missing in isoform 3. 1 PublicationAdd BLAST2207
Alternative sequenceiVSP_0505392539E → EIPEAYFIRDPHTFLLTKDF IK in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF467288 mRNA. Translation: AAM53531.1.
AL138690 Genomic DNA. No translation available.
AK001059 mRNA. Translation: BAA91485.1. Sequence problems.
AK294737 mRNA. Translation: BAH11865.1.
AL139083, AL390071 Genomic DNA. Translation: CAH71883.1.
AL159160 Genomic DNA. No translation available.
AL161718 Genomic DNA. No translation available.
AL161902 Genomic DNA. No translation available.
AL356430 Genomic DNA. No translation available.
AL357083 Genomic DNA. No translation available.
AL390071, AL139083 Genomic DNA. Translation: CAI17183.1.
AB046764 mRNA. Translation: BAB13370.1.
AL137748 mRNA. Translation: CAB70903.2.
AF072371 mRNA. Translation: AAD41633.1. Frameshift.
CCDSiCCDS45026.1. [Q8NFP9-1]
CCDS55894.1. [Q8NFP9-3]
PIRiT46310.
RefSeqiNP_001191126.1. NM_001204197.1. [Q8NFP9-3]
NP_056493.3. NM_015678.4. [Q8NFP9-1]
UniGeneiHs.491172.

Genome annotation databases

EnsembliENST00000379922; ENSP00000369254; ENSG00000172915. [Q8NFP9-2]
ENST00000400445; ENSP00000383295; ENSG00000172915. [Q8NFP9-1]
ENST00000537702; ENSP00000440233; ENSG00000172915. [Q8NFP9-3]
GeneIDi26960.
KEGGihsa:26960.
UCSCiuc058wka.1. human. [Q8NFP9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF467288 mRNA. Translation: AAM53531.1.
AL138690 Genomic DNA. No translation available.
AK001059 mRNA. Translation: BAA91485.1. Sequence problems.
AK294737 mRNA. Translation: BAH11865.1.
AL139083, AL390071 Genomic DNA. Translation: CAH71883.1.
AL159160 Genomic DNA. No translation available.
AL161718 Genomic DNA. No translation available.
AL161902 Genomic DNA. No translation available.
AL356430 Genomic DNA. No translation available.
AL357083 Genomic DNA. No translation available.
AL390071, AL139083 Genomic DNA. Translation: CAI17183.1.
AB046764 mRNA. Translation: BAB13370.1.
AL137748 mRNA. Translation: CAB70903.2.
AF072371 mRNA. Translation: AAD41633.1. Frameshift.
CCDSiCCDS45026.1. [Q8NFP9-1]
CCDS55894.1. [Q8NFP9-3]
PIRiT46310.
RefSeqiNP_001191126.1. NM_001204197.1. [Q8NFP9-3]
NP_056493.3. NM_015678.4. [Q8NFP9-1]
UniGeneiHs.491172.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MI1X-ray2.90A/B2150-2563[»]
ProteinModelPortaliQ8NFP9.
SMRiQ8NFP9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117928. 13 interactors.
IntActiQ8NFP9. 7 interactors.
MINTiMINT-1380608.
STRINGi9606.ENSP00000383295.

PTM databases

iPTMnetiQ8NFP9.
PhosphoSitePlusiQ8NFP9.

Polymorphism and mutation databases

BioMutaiNBEA.
DMDMi296439289.

Proteomic databases

EPDiQ8NFP9.
MaxQBiQ8NFP9.
PaxDbiQ8NFP9.
PeptideAtlasiQ8NFP9.
PRIDEiQ8NFP9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379922; ENSP00000369254; ENSG00000172915. [Q8NFP9-2]
ENST00000400445; ENSP00000383295; ENSG00000172915. [Q8NFP9-1]
ENST00000537702; ENSP00000440233; ENSG00000172915. [Q8NFP9-3]
GeneIDi26960.
KEGGihsa:26960.
UCSCiuc058wka.1. human. [Q8NFP9-1]

Organism-specific databases

CTDi26960.
DisGeNETi26960.
GeneCardsiNBEA.
H-InvDBHIX0029795.
HGNCiHGNC:7648. NBEA.
HPAiHPA039730.
HPA040385.
MIMi604889. gene.
neXtProtiNX_Q8NFP9.
OpenTargetsiENSG00000172915.
PharmGKBiPA31454.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1786. Eukaryota.
ENOG410XNQC. LUCA.
GeneTreeiENSGT00760000119083.
HOGENOMiHOG000082375.
HOVERGENiHBG012582.
InParanoidiQ8NFP9.
PhylomeDBiQ8NFP9.
TreeFamiTF313490.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172915-MONOMER.
SignaLinkiQ8NFP9.

Miscellaneous databases

ChiTaRSiNBEA. human.
EvolutionaryTraceiQ8NFP9.
GenomeRNAii26960.
PROiQ8NFP9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172915.
CleanExiHS_NBEA.
ExpressionAtlasiQ8NFP9. baseline and differential.
GenevisibleiQ8NFP9. HS.

Family and domain databases

CDDicd06071. Beach. 1 hit.
Gene3Di1.10.1540.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.40. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000409. BEACH_dom.
IPR013320. ConA-like_dom.
IPR010508. DUF1088.
IPR031570. DUF4704.
IPR023362. PH-BEACH_dom.
IPR011993. PH_dom-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF02138. Beach. 1 hit.
PF06469. DUF1088. 1 hit.
PF15787. DUF4704. 1 hit.
PF14844. PH_BEACH. 1 hit.
[Graphical view]
SMARTiSM01026. Beach. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEiPS50197. BEACH. 1 hit.
PS51783. PH_BEACH. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNBEA_HUMAN
AccessioniPrimary (citable) accession number: Q8NFP9
Secondary accession number(s): B7Z2H9
, Q5T320, Q9HCM8, Q9NSU1, Q9NW98, Q9Y6J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 149 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.