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Q8NFP9

- NBEA_HUMAN

UniProt

Q8NFP9 - NBEA_HUMAN

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Protein
Neurobeachin
Gene
NBEA, BCL8B, KIAA1544, LYST2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins By similarity.By similarity

GO - Biological processi

  1. protein localization Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ8NFP9.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurobeachin
Alternative name(s):
Lysosomal-trafficking regulator 2
Protein BCL8B
Gene namesi
Name:NBEA
Synonyms:BCL8B, KIAA1544, LYST2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:7648. NBEA.

Subcellular locationi

Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. endomembrane system Source: UniProtKB
  3. plasma membrane Source: UniProtKB
  4. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31454.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 29462946Neurobeachin
PRO_0000051089Add
BLAST

Proteomic databases

MaxQBiQ8NFP9.
PRIDEiQ8NFP9.

PTM databases

PhosphoSiteiQ8NFP9.

Expressioni

Tissue specificityi

Predominant in many brain structures. Also expressed at medium levels in spleen, thymus, prostate, testis and ovary. Low level expression is seen in heart, kidney, pancreas, skeletal muscle and intestine.1 Publication

Gene expression databases

ArrayExpressiQ8NFP9.
BgeeiQ8NFP9.
CleanExiHS_NBEA.
GenevestigatoriQ8NFP9.

Organism-specific databases

HPAiHPA039730.
HPA040385.

Interactioni

Subunit structurei

Interacts with RII subunit of PKA By similarity.By similarity

Protein-protein interaction databases

BioGridi117928. 6 interactions.
IntActiQ8NFP9. 6 interactions.
MINTiMINT-1380608.
STRINGi9606.ENSP00000383295.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2154 – 21629
Beta strandi2165 – 21739
Beta strandi2175 – 21828
Helixi2187 – 21904
Helixi2194 – 21996
Beta strandi2206 – 22083
Helixi2209 – 22113
Beta strandi2212 – 22209
Beta strandi2223 – 22319
Beta strandi2236 – 22405
Helixi2244 – 22529
Helixi2269 – 22735
Helixi2276 – 22816
Helixi2285 – 22906
Helixi2296 – 230611
Helixi2314 – 23163
Beta strandi2328 – 23314
Helixi2337 – 23393
Helixi2347 – 23493
Helixi2352 – 236312
Beta strandi2374 – 23774
Helixi2382 – 23887
Turni2389 – 23913
Helixi2395 – 24017
Turni2402 – 24054
Turni2410 – 24123
Helixi2417 – 242610
Helixi2436 – 24394
Helixi2442 – 24454
Helixi2474 – 248512
Helixi2488 – 24914
Helixi2494 – 25018
Beta strandi2506 – 25083
Helixi2509 – 25135
Turni2520 – 25223
Turni2529 – 25313
Helixi2535 – 254814

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MI1X-ray2.90A/B2150-2563[»]
ProteinModelPortaliQ8NFP9.
SMRiQ8NFP9. Positions 2150-2563, 2692-2900.

Miscellaneous databases

EvolutionaryTraceiQ8NFP9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1326 – 136843WD 1
Add
BLAST
Domaini2274 – 2563290BEACH
Add
BLAST
Repeati2718 – 276144WD 2
Add
BLAST
Repeati2778 – 281841WD 3
Add
BLAST
Repeati2860 – 289940WD 4
Add
BLAST
Repeati2902 – 294140WD 5
Add
BLAST

Domaini

RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer By similarity.By similarity

Sequence similaritiesi

Contains 1 BEACH domain.
Contains 5 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000082375.
HOVERGENiHBG012582.
InParanoidiQ8NFP9.
PhylomeDBiQ8NFP9.
TreeFamiTF313490.

Family and domain databases

Gene3Di1.10.1540.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.40. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000409. BEACH_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR010508. DUF1088.
IPR023362. PH-BEACH_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF02138. Beach. 1 hit.
PF06469. DUF1088. 1 hit.
PF14844. PH_BEACH. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM01026. Beach. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEiPS50197. BEACH. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NFP9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASEKPGPGP GLEPQPVGLI AVGAAGGGGG GSGGGGTGGS GMGELRGASG     50
SGSVMLPAGM INPSVPIRNI RMKFAVLIGL IQVGEVSNRD IVETVLNLLV 100
GGEFDLEMNF IIQDAESITC MTELLEHCDV TCQAEIWSMF TAILRKSVRN 150
LQTSTEVGLI EQVLLKMSAV DDMIADLLVD MLGVLASYSI TVKELKLLFS 200
MLRGESGIWP RHAVKLLSVL NQMPQRHGPD TFFNFPGCSA AAIALPPIAK 250
WPYQNGFTLN TWFRMDPLNN INVDKDKPYL YCFRTSKGVG YSAHFVGNCL 300
IVTSLKSKGK GFQHCVKYDF QPRKWYMISI VHIYNRWRNS EIRCYVNGQL 350
VSYGDMAWHV NTNDSYDKCF LGSSETADAN RVFCGQLGAV YVFSEALNPA 400
QIFAIHQLGP GYKSTFKFKS ESDIHLAEHH KQVLYDGKLA SSIAFTYNAK 450
ATDAQLCLES SPKENASIFV HSPHALMLQD VKAIVTHSIH SAIHSIGGIQ 500
VLFPLFAQLD NRQLNDSQVE TTVCATLLAF LVELLKSSVA MQEQMLGGKG 550
FLVIGYLLEK SSRVHITRAV LEQFLSFAKY LDGLSHGAPL LKQLCDHILF 600
NPAIWIHTPA KVQLSLYTYL SAEFIGTATI YTTIRRVGTV LQLMHTLKYY 650
YWVINPADSS GITPKGLDGP RPSQKEIISL RAFMLLFLKQ LILKDRGVKE 700
DELQSILNYL LTMHEDENIH DVLQLLVALM SEHPASMIPA FDQRNGIRVI 750
YKLLASKSES IWVQALKVLG YFLKHLGHKR KVEIMHTHSL FTLLGERLML 800
HTNTVTVTTY NTLYEILTEQ VCTQVVHKPH PEPDSTVKIQ NPMILKVVAT 850
LLKNSTPSAE LMEVRRLFLS DMIKLFSNSR ENRRCLLQCS VWQDWMFSLG 900
YINPKNSEEQ KITEMVYNIF RILLYHAIKY EWGGWRVWVD TLSIAHSKVT 950
YEAHKEYLAK MYEEYQRQEE ENIKKGKKGN VSTISGLSSQ TTGAKGGMEI 1000
REIEDLSQSQ SPESETDYPV STDTRDLLMS TKVSDDILGN SDRPGSGVHV 1050
EVHDLLVDIK AEKVEATEVK LDDMDLSPET LVGGENGALV EVESLLDNVY 1100
SAAVEKLQNN VHGSVGIIKK NEEKDNGPLI TLADEKEDLP NSSTSFLFDK 1150
IPKQEEKLLP ELSSNHIIPN IQDTQVHLGV SDDLGLLAHM TGSVDLTCTS 1200
SIIEEKEFKI HTTSDGMSSI SERDLASSTK GLEYAEMTAT TLETESSSSK 1250
IVPNIDAGSI ISDTERSDDG KESGKEIRKI QTTTTTQAVQ GRSITQQDRD 1300
LRVDLGFRGM PMTEEQRRQF SPGPRTTMFR IPEFKWSPMH QRLLTDLLFA 1350
LETDVHVWRS HSTKSVMDFV NSNENIIFVH NTIHLISQMV DNIIIACGGI 1400
LPLLSAATSP TGSKTELENI EVTQGMSAET AVTFLSRLMA MVDVLVFASS 1450
LNFSEIEAEK NMSSGGLMRQ CLRLVCCVAV RNCLECRQRQ RDRGNKSSHG 1500
SSKPQEVPQS VTATAASKTP LENVPGNLSP IKDPDRLLQD VDINRLRAVV 1550
FRDVDDSKQA QFLALAVVYF ISVLMVSKYR DILEPQRETT RTGSQPGRNI 1600
RQEINSPTST VVVIPSIPHP SLNHGFLAKL IPEQSFGHSF YKETPAAFPD 1650
TIKEKETPTP GEDIQVESSI PHTDSGIGEE QVASILNGAE LETSTGPDAM 1700
SELLSTLSSE VKKSQESLTE NPSETLKPAT SISSISQTKG INVKEILKSL 1750
VAAPVEIAEC GPEPIPYPDP ALKRETQAIL PMQFHSFDRS VVVPVKKPPP 1800
GSLAVTTVGA TTAGSGLPTG STSNIFAATG ATPKSMINTT GAVDSGSSSS 1850
SSSSSFVNGA TSKNLPAVQT VAPMPEDSAE NMSITAKLER ALEKVAPLLR 1900
EIFVDFAPFL SRTLLGSHGQ ELLIEGLVCM KSSTSVVELV MLLCSQEWQN 1950
SIQKNAGLAF IELINEGRLL CHAMKDHIVR VANEAEFILN RQRAEDVHKH 2000
AEFESQCAQY AADRREEEKM CDHLISAAKH RDHVTANQLK QKILNILTNK 2050
HGAWGAVSHS QLHDFWRLDY WEDDLRRRRR FVRNAFGSTH AEALLKAAIE 2100
YGTEEDVVKS KKTFRSQAIV NQNAETELML EGDDDAVSLL QEKEIDNLAG 2150
PVVLSTPAQL IAPVVVAKGT LSITTTEIYF EVDEDDSAFK KIDTKVLAYT 2200
EGLHGKWMFS EIRAVFSRRY LLQNTALEVF MANRTSVMFN FPDQATVKKV 2250
VYSLPRVGVG TSYGLPQARR ISLATPRQLY KSSNMTQRWQ RREISNFEYL 2300
MFLNTIAGRT YNDLNQYPVF PWVLTNYESE ELDLTLPGNF RDLSKPIGAL 2350
NPKRAVFYAE RYETWEDDQS PPYHYNTHYS TATSTLSWLV RIEPFTTFFL 2400
NANDGKFDHP DRTFSSVARS WRTSQRDTSD VKELIPEFYY LPEMFVNSNG 2450
YNLGVREDEV VVNDVDLPPW AKKPEDFVRI NRMALESEFV SCQLHQWIDL 2500
IFGYKQRGPE AVRALNVFHY LTYEGSVNLD SITDPVLREA MEAQIQNFGQ 2550
TPSQLLIEPH PPRSSAMHLC FLPQSPLMFK DQMQQDVIMV LKFPSNSPVT 2600
HVAANTLPHL TIPAVVTVTC SRLFAVNRWH NTVGLRGAPG YSLDQAHHLP 2650
IEMDPLIANN SGVNKRQITD LVDQSIQINA HCFVVTADNR YILICGFWDK 2700
SFRVYSTETG KLTQIVFGHW DVVTCLARSE SYIGGDCYIV SGSRDATLLL 2750
WYWSGRHHII GDNPNSSDYP APRAVLTGHD HEVVCVSVCA ELGLVISGAK 2800
EGPCLVHTIT GDLLRALEGP ENCLFPRLIS VSSEGHCIIY YERGRFSNFS 2850
INGKLLAQME INDSTRAILL SSDGQNLVTG GDNGVVEVWQ ACDFKQLYIY 2900
PGCDAGIRAM DLSHDQRTLI TGMASGSIVA FNIDFNRWHY EHQNRY 2946
Length:2,946
Mass (Da):327,822
Last modified:May 18, 2010 - v3
Checksum:i2E371FDA2F00781E
GO
Isoform 2 (identifier: Q8NFP9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2443: Missing.
     2539-2539: E → EIPEAYFIRDPHTFLLTKDFIK

Note: No experimental confirmation available.

Show »
Length:524
Mass (Da):58,802
Checksum:iF4A38C3EFE58D390
GO
Isoform 3 (identifier: Q8NFP9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2207: Missing.

Note: No experimental confirmation available.

Show »
Length:739
Mass (Da):84,001
Checksum:i38BA7126B5FFBBE7
GO

Sequence cautioni

The sequence AAD41633.1 differs from that shown. Reason: Frameshift at position 2900.
The sequence BAA91485.1 differs from that shown. Reason: Erroneous termination at position 762. Translated as Trp.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti569 – 5691A → P.
Corresponds to variant rs5011295 [ dbSNP | Ensembl ].
VAR_047658
Natural varianti2501 – 25011I → V.
Corresponds to variant rs11538677 [ dbSNP | Ensembl ].
VAR_047659

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 24432443Missing in isoform 2.
VSP_050538Add
BLAST
Alternative sequencei1 – 22072207Missing in isoform 3.
VSP_046397Add
BLAST
Alternative sequencei2539 – 25391E → EIPEAYFIRDPHTFLLTKDF IK in isoform 2.
VSP_050539

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1658 – 16581P → S in AAM53531. 1 Publication
Sequence conflicti2564 – 25641S → N in AAD41633. 1 Publication
Sequence conflicti2706 – 27061S → T in AAD41633. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF467288 mRNA. Translation: AAM53531.1.
AL138690 Genomic DNA. No translation available.
AK001059 mRNA. Translation: BAA91485.1. Sequence problems.
AK294737 mRNA. Translation: BAH11865.1.
AL139083, AL390071 Genomic DNA. Translation: CAH71883.1.
AL159160 Genomic DNA. No translation available.
AL161718 Genomic DNA. No translation available.
AL161902 Genomic DNA. No translation available.
AL356430 Genomic DNA. No translation available.
AL357083 Genomic DNA. No translation available.
AL390071, AL139083 Genomic DNA. Translation: CAI17183.1.
AB046764 mRNA. Translation: BAB13370.1.
AL137748 mRNA. Translation: CAB70903.2.
AF072371 mRNA. Translation: AAD41633.1. Frameshift.
CCDSiCCDS45026.1. [Q8NFP9-1]
CCDS55894.1. [Q8NFP9-3]
PIRiT46310.
RefSeqiNP_001191126.1. NM_001204197.1. [Q8NFP9-3]
NP_056493.3. NM_015678.4. [Q8NFP9-1]
UniGeneiHs.491172.

Genome annotation databases

EnsembliENST00000379922; ENSP00000369254; ENSG00000172915. [Q8NFP9-2]
ENST00000400445; ENSP00000383295; ENSG00000172915. [Q8NFP9-1]
ENST00000537702; ENSP00000440233; ENSG00000172915. [Q8NFP9-3]
GeneIDi26960.
KEGGihsa:26960.
UCSCiuc001uvd.3. human. [Q8NFP9-2]
uc010tee.1. human.
uc021ric.1. human. [Q8NFP9-1]

Polymorphism databases

DMDMi296439289.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF467288 mRNA. Translation: AAM53531.1 .
AL138690 Genomic DNA. No translation available.
AK001059 mRNA. Translation: BAA91485.1 . Sequence problems.
AK294737 mRNA. Translation: BAH11865.1 .
AL139083 , AL390071 Genomic DNA. Translation: CAH71883.1 .
AL159160 Genomic DNA. No translation available.
AL161718 Genomic DNA. No translation available.
AL161902 Genomic DNA. No translation available.
AL356430 Genomic DNA. No translation available.
AL357083 Genomic DNA. No translation available.
AL390071 , AL139083 Genomic DNA. Translation: CAI17183.1 .
AB046764 mRNA. Translation: BAB13370.1 .
AL137748 mRNA. Translation: CAB70903.2 .
AF072371 mRNA. Translation: AAD41633.1 . Frameshift.
CCDSi CCDS45026.1. [Q8NFP9-1 ]
CCDS55894.1. [Q8NFP9-3 ]
PIRi T46310.
RefSeqi NP_001191126.1. NM_001204197.1. [Q8NFP9-3 ]
NP_056493.3. NM_015678.4. [Q8NFP9-1 ]
UniGenei Hs.491172.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1MI1 X-ray 2.90 A/B 2150-2563 [» ]
ProteinModelPortali Q8NFP9.
SMRi Q8NFP9. Positions 2150-2563, 2692-2900.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117928. 6 interactions.
IntActi Q8NFP9. 6 interactions.
MINTi MINT-1380608.
STRINGi 9606.ENSP00000383295.

PTM databases

PhosphoSitei Q8NFP9.

Polymorphism databases

DMDMi 296439289.

Proteomic databases

MaxQBi Q8NFP9.
PRIDEi Q8NFP9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000379922 ; ENSP00000369254 ; ENSG00000172915 . [Q8NFP9-2 ]
ENST00000400445 ; ENSP00000383295 ; ENSG00000172915 . [Q8NFP9-1 ]
ENST00000537702 ; ENSP00000440233 ; ENSG00000172915 . [Q8NFP9-3 ]
GeneIDi 26960.
KEGGi hsa:26960.
UCSCi uc001uvd.3. human. [Q8NFP9-2 ]
uc010tee.1. human.
uc021ric.1. human. [Q8NFP9-1 ]

Organism-specific databases

CTDi 26960.
GeneCardsi GC13P035516.
H-InvDB HIX0029795.
HGNCi HGNC:7648. NBEA.
HPAi HPA039730.
HPA040385.
MIMi 604889. gene.
neXtProti NX_Q8NFP9.
PharmGKBi PA31454.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000082375.
HOVERGENi HBG012582.
InParanoidi Q8NFP9.
PhylomeDBi Q8NFP9.
TreeFami TF313490.

Enzyme and pathway databases

SignaLinki Q8NFP9.

Miscellaneous databases

ChiTaRSi NBEA. human.
EvolutionaryTracei Q8NFP9.
GenomeRNAii 26960.
NextBioi 49420.
PROi Q8NFP9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8NFP9.
Bgeei Q8NFP9.
CleanExi HS_NBEA.
Genevestigatori Q8NFP9.

Family and domain databases

Gene3Di 1.10.1540.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.40. 1 hit.
2.60.120.200. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR000409. BEACH_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR010508. DUF1088.
IPR023362. PH-BEACH_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF02138. Beach. 1 hit.
PF06469. DUF1088. 1 hit.
PF14844. PH_BEACH. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM01026. Beach. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEi PS50197. BEACH. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "BCL8 is a novel, evolutionarily conserved human gene family encoding proteins with presumptive protein kinase A anchoring function."
    Dyomin V.G., Chaganti S.R., Dyomina K., Palanisamy N., Murty V.V.V.S., Dalla-Favera R., Chaganti R.S.K.
    Genomics 80:158-165(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Brain and Spleen.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 606-1118 (ISOFORMS 1/2).
    Tissue: Brain and Embryonic head.
  3. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1919-2946 (ISOFORM 1).
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2393-2946 (ISOFORM 2).
    Tissue: Testis.
  6. "Identification of LYST2, a brain-specific member of the Chediak-Higashi syndrome gene family."
    Tchernev V.T., McMurtrie E.B., Nguyen Q.A., Mishra V.S., Barbosa M.D.F.S., McIndoe R., Kingsmore S.F.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2428-2946 (ISOFORM 1).
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain."
    Jogl G., Shen Y., Gebauer D., Li J., Wiegmann K., Kashkar H., Kroenke M., Tong L.
    EMBO J. 21:4785-4795(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 2150-2563.

Entry informationi

Entry nameiNBEA_HUMAN
AccessioniPrimary (citable) accession number: Q8NFP9
Secondary accession number(s): B7Z2H9
, Q5T320, Q9HCM8, Q9NSU1, Q9NW98, Q9Y6J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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