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Q8NFP9

- NBEA_HUMAN

UniProt

Q8NFP9 - NBEA_HUMAN

Protein

Neurobeachin

Gene

NBEA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins By similarity.By similarity

    GO - Biological processi

    1. protein localization Source: Ensembl

    Enzyme and pathway databases

    SignaLinkiQ8NFP9.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurobeachin
    Alternative name(s):
    Lysosomal-trafficking regulator 2
    Protein BCL8B
    Gene namesi
    Name:NBEA
    Synonyms:BCL8B, KIAA1544, LYST2
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:7648. NBEA.

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. endomembrane system Source: UniProtKB
    3. plasma membrane Source: UniProtKB
    4. trans-Golgi network Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31454.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 29462946NeurobeachinPRO_0000051089Add
    BLAST

    Proteomic databases

    MaxQBiQ8NFP9.
    PRIDEiQ8NFP9.

    PTM databases

    PhosphoSiteiQ8NFP9.

    Expressioni

    Tissue specificityi

    Predominant in many brain structures. Also expressed at medium levels in spleen, thymus, prostate, testis and ovary. Low level expression is seen in heart, kidney, pancreas, skeletal muscle and intestine.1 Publication

    Gene expression databases

    ArrayExpressiQ8NFP9.
    BgeeiQ8NFP9.
    CleanExiHS_NBEA.
    GenevestigatoriQ8NFP9.

    Organism-specific databases

    HPAiHPA039730.
    HPA040385.

    Interactioni

    Subunit structurei

    Interacts with RII subunit of PKA.By similarity

    Protein-protein interaction databases

    BioGridi117928. 6 interactions.
    IntActiQ8NFP9. 6 interactions.
    MINTiMINT-1380608.
    STRINGi9606.ENSP00000383295.

    Structurei

    Secondary structure

    1
    2946
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2154 – 21629
    Beta strandi2165 – 21739
    Beta strandi2175 – 21828
    Helixi2187 – 21904
    Helixi2194 – 21996
    Beta strandi2206 – 22083
    Helixi2209 – 22113
    Beta strandi2212 – 22209
    Beta strandi2223 – 22319
    Beta strandi2236 – 22405
    Helixi2244 – 22529
    Helixi2269 – 22735
    Helixi2276 – 22816
    Helixi2285 – 22906
    Helixi2296 – 230611
    Helixi2314 – 23163
    Beta strandi2328 – 23314
    Helixi2337 – 23393
    Helixi2347 – 23493
    Helixi2352 – 236312
    Beta strandi2374 – 23774
    Helixi2382 – 23887
    Turni2389 – 23913
    Helixi2395 – 24017
    Turni2402 – 24054
    Turni2410 – 24123
    Helixi2417 – 242610
    Helixi2436 – 24394
    Helixi2442 – 24454
    Helixi2474 – 248512
    Helixi2488 – 24914
    Helixi2494 – 25018
    Beta strandi2506 – 25083
    Helixi2509 – 25135
    Turni2520 – 25223
    Turni2529 – 25313
    Helixi2535 – 254814

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1MI1X-ray2.90A/B2150-2563[»]
    ProteinModelPortaliQ8NFP9.
    SMRiQ8NFP9. Positions 2150-2563, 2692-2900.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8NFP9.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati1326 – 136843WD 1CuratedAdd
    BLAST
    Domaini2274 – 2563290BEACHCuratedPROSITE-ProRule annotationAdd
    BLAST
    Repeati2718 – 276144WD 2CuratedAdd
    BLAST
    Repeati2778 – 281841WD 3CuratedAdd
    BLAST
    Repeati2860 – 289940WD 4CuratedAdd
    BLAST
    Repeati2902 – 294140WD 5CuratedAdd
    BLAST

    Domaini

    RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.By similarity

    Sequence similaritiesi

    Belongs to the WD repeat neurobeachin family.Curated
    Contains 1 BEACH domain.CuratedPROSITE-ProRule annotation
    Contains 5 WD repeats.CuratedPROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    HOGENOMiHOG000082375.
    HOVERGENiHBG012582.
    InParanoidiQ8NFP9.
    PhylomeDBiQ8NFP9.
    TreeFamiTF313490.

    Family and domain databases

    Gene3Di1.10.1540.10. 1 hit.
    2.130.10.10. 1 hit.
    2.30.29.40. 1 hit.
    2.60.120.200. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR000409. BEACH_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR010508. DUF1088.
    IPR023362. PH-BEACH_dom.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF02138. Beach. 1 hit.
    PF06469. DUF1088. 1 hit.
    PF14844. PH_BEACH. 1 hit.
    PF00400. WD40. 1 hit.
    [Graphical view]
    SMARTiSM01026. Beach. 1 hit.
    SM00320. WD40. 5 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.
    SSF49899. SSF49899. 1 hit.
    SSF50978. SSF50978. 1 hit.
    SSF81837. SSF81837. 1 hit.
    PROSITEiPS50197. BEACH. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1Curated (identifier: Q8NFP9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASEKPGPGP GLEPQPVGLI AVGAAGGGGG GSGGGGTGGS GMGELRGASG     50
    SGSVMLPAGM INPSVPIRNI RMKFAVLIGL IQVGEVSNRD IVETVLNLLV 100
    GGEFDLEMNF IIQDAESITC MTELLEHCDV TCQAEIWSMF TAILRKSVRN 150
    LQTSTEVGLI EQVLLKMSAV DDMIADLLVD MLGVLASYSI TVKELKLLFS 200
    MLRGESGIWP RHAVKLLSVL NQMPQRHGPD TFFNFPGCSA AAIALPPIAK 250
    WPYQNGFTLN TWFRMDPLNN INVDKDKPYL YCFRTSKGVG YSAHFVGNCL 300
    IVTSLKSKGK GFQHCVKYDF QPRKWYMISI VHIYNRWRNS EIRCYVNGQL 350
    VSYGDMAWHV NTNDSYDKCF LGSSETADAN RVFCGQLGAV YVFSEALNPA 400
    QIFAIHQLGP GYKSTFKFKS ESDIHLAEHH KQVLYDGKLA SSIAFTYNAK 450
    ATDAQLCLES SPKENASIFV HSPHALMLQD VKAIVTHSIH SAIHSIGGIQ 500
    VLFPLFAQLD NRQLNDSQVE TTVCATLLAF LVELLKSSVA MQEQMLGGKG 550
    FLVIGYLLEK SSRVHITRAV LEQFLSFAKY LDGLSHGAPL LKQLCDHILF 600
    NPAIWIHTPA KVQLSLYTYL SAEFIGTATI YTTIRRVGTV LQLMHTLKYY 650
    YWVINPADSS GITPKGLDGP RPSQKEIISL RAFMLLFLKQ LILKDRGVKE 700
    DELQSILNYL LTMHEDENIH DVLQLLVALM SEHPASMIPA FDQRNGIRVI 750
    YKLLASKSES IWVQALKVLG YFLKHLGHKR KVEIMHTHSL FTLLGERLML 800
    HTNTVTVTTY NTLYEILTEQ VCTQVVHKPH PEPDSTVKIQ NPMILKVVAT 850
    LLKNSTPSAE LMEVRRLFLS DMIKLFSNSR ENRRCLLQCS VWQDWMFSLG 900
    YINPKNSEEQ KITEMVYNIF RILLYHAIKY EWGGWRVWVD TLSIAHSKVT 950
    YEAHKEYLAK MYEEYQRQEE ENIKKGKKGN VSTISGLSSQ TTGAKGGMEI 1000
    REIEDLSQSQ SPESETDYPV STDTRDLLMS TKVSDDILGN SDRPGSGVHV 1050
    EVHDLLVDIK AEKVEATEVK LDDMDLSPET LVGGENGALV EVESLLDNVY 1100
    SAAVEKLQNN VHGSVGIIKK NEEKDNGPLI TLADEKEDLP NSSTSFLFDK 1150
    IPKQEEKLLP ELSSNHIIPN IQDTQVHLGV SDDLGLLAHM TGSVDLTCTS 1200
    SIIEEKEFKI HTTSDGMSSI SERDLASSTK GLEYAEMTAT TLETESSSSK 1250
    IVPNIDAGSI ISDTERSDDG KESGKEIRKI QTTTTTQAVQ GRSITQQDRD 1300
    LRVDLGFRGM PMTEEQRRQF SPGPRTTMFR IPEFKWSPMH QRLLTDLLFA 1350
    LETDVHVWRS HSTKSVMDFV NSNENIIFVH NTIHLISQMV DNIIIACGGI 1400
    LPLLSAATSP TGSKTELENI EVTQGMSAET AVTFLSRLMA MVDVLVFASS 1450
    LNFSEIEAEK NMSSGGLMRQ CLRLVCCVAV RNCLECRQRQ RDRGNKSSHG 1500
    SSKPQEVPQS VTATAASKTP LENVPGNLSP IKDPDRLLQD VDINRLRAVV 1550
    FRDVDDSKQA QFLALAVVYF ISVLMVSKYR DILEPQRETT RTGSQPGRNI 1600
    RQEINSPTST VVVIPSIPHP SLNHGFLAKL IPEQSFGHSF YKETPAAFPD 1650
    TIKEKETPTP GEDIQVESSI PHTDSGIGEE QVASILNGAE LETSTGPDAM 1700
    SELLSTLSSE VKKSQESLTE NPSETLKPAT SISSISQTKG INVKEILKSL 1750
    VAAPVEIAEC GPEPIPYPDP ALKRETQAIL PMQFHSFDRS VVVPVKKPPP 1800
    GSLAVTTVGA TTAGSGLPTG STSNIFAATG ATPKSMINTT GAVDSGSSSS 1850
    SSSSSFVNGA TSKNLPAVQT VAPMPEDSAE NMSITAKLER ALEKVAPLLR 1900
    EIFVDFAPFL SRTLLGSHGQ ELLIEGLVCM KSSTSVVELV MLLCSQEWQN 1950
    SIQKNAGLAF IELINEGRLL CHAMKDHIVR VANEAEFILN RQRAEDVHKH 2000
    AEFESQCAQY AADRREEEKM CDHLISAAKH RDHVTANQLK QKILNILTNK 2050
    HGAWGAVSHS QLHDFWRLDY WEDDLRRRRR FVRNAFGSTH AEALLKAAIE 2100
    YGTEEDVVKS KKTFRSQAIV NQNAETELML EGDDDAVSLL QEKEIDNLAG 2150
    PVVLSTPAQL IAPVVVAKGT LSITTTEIYF EVDEDDSAFK KIDTKVLAYT 2200
    EGLHGKWMFS EIRAVFSRRY LLQNTALEVF MANRTSVMFN FPDQATVKKV 2250
    VYSLPRVGVG TSYGLPQARR ISLATPRQLY KSSNMTQRWQ RREISNFEYL 2300
    MFLNTIAGRT YNDLNQYPVF PWVLTNYESE ELDLTLPGNF RDLSKPIGAL 2350
    NPKRAVFYAE RYETWEDDQS PPYHYNTHYS TATSTLSWLV RIEPFTTFFL 2400
    NANDGKFDHP DRTFSSVARS WRTSQRDTSD VKELIPEFYY LPEMFVNSNG 2450
    YNLGVREDEV VVNDVDLPPW AKKPEDFVRI NRMALESEFV SCQLHQWIDL 2500
    IFGYKQRGPE AVRALNVFHY LTYEGSVNLD SITDPVLREA MEAQIQNFGQ 2550
    TPSQLLIEPH PPRSSAMHLC FLPQSPLMFK DQMQQDVIMV LKFPSNSPVT 2600
    HVAANTLPHL TIPAVVTVTC SRLFAVNRWH NTVGLRGAPG YSLDQAHHLP 2650
    IEMDPLIANN SGVNKRQITD LVDQSIQINA HCFVVTADNR YILICGFWDK 2700
    SFRVYSTETG KLTQIVFGHW DVVTCLARSE SYIGGDCYIV SGSRDATLLL 2750
    WYWSGRHHII GDNPNSSDYP APRAVLTGHD HEVVCVSVCA ELGLVISGAK 2800
    EGPCLVHTIT GDLLRALEGP ENCLFPRLIS VSSEGHCIIY YERGRFSNFS 2850
    INGKLLAQME INDSTRAILL SSDGQNLVTG GDNGVVEVWQ ACDFKQLYIY 2900
    PGCDAGIRAM DLSHDQRTLI TGMASGSIVA FNIDFNRWHY EHQNRY 2946
    Length:2,946
    Mass (Da):327,822
    Last modified:May 18, 2010 - v3
    Checksum:i2E371FDA2F00781E
    GO
    Isoform 2Curated (identifier: Q8NFP9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-2443: Missing.
         2539-2539: E → EIPEAYFIRDPHTFLLTKDFIK

    Note: No experimental confirmation available.Curated

    Show »
    Length:524
    Mass (Da):58,802
    Checksum:iF4A38C3EFE58D390
    GO
    Isoform 3 (identifier: Q8NFP9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-2207: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:739
    Mass (Da):84,001
    Checksum:i38BA7126B5FFBBE7
    GO

    Sequence cautioni

    The sequence AAD41633.1 differs from that shown. Reason: Frameshift at position 2900.
    The sequence BAA91485.1 differs from that shown. Reason: Erroneous termination at position 762. Translated as Trp.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1658 – 16581P → S in AAM53531. (PubMed:12160729)Curated
    Sequence conflicti2564 – 25641S → N in AAD41633. 1 PublicationCurated
    Sequence conflicti2706 – 27061S → T in AAD41633. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti569 – 5691A → P.
    Corresponds to variant rs5011295 [ dbSNP | Ensembl ].
    VAR_047658
    Natural varianti2501 – 25011I → V.
    Corresponds to variant rs11538677 [ dbSNP | Ensembl ].
    VAR_047659

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 24432443Missing in isoform 2. 1 PublicationVSP_050538Add
    BLAST
    Alternative sequencei1 – 22072207Missing in isoform 3. 1 PublicationVSP_046397Add
    BLAST
    Alternative sequencei2539 – 25391E → EIPEAYFIRDPHTFLLTKDF IK in isoform 2. 1 PublicationVSP_050539

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF467288 mRNA. Translation: AAM53531.1.
    AL138690 Genomic DNA. No translation available.
    AK001059 mRNA. Translation: BAA91485.1. Sequence problems.
    AK294737 mRNA. Translation: BAH11865.1.
    AL139083, AL390071 Genomic DNA. Translation: CAH71883.1.
    AL159160 Genomic DNA. No translation available.
    AL161718 Genomic DNA. No translation available.
    AL161902 Genomic DNA. No translation available.
    AL356430 Genomic DNA. No translation available.
    AL357083 Genomic DNA. No translation available.
    AL390071, AL139083 Genomic DNA. Translation: CAI17183.1.
    AB046764 mRNA. Translation: BAB13370.1.
    AL137748 mRNA. Translation: CAB70903.2.
    AF072371 mRNA. Translation: AAD41633.1. Frameshift.
    CCDSiCCDS45026.1. [Q8NFP9-1]
    CCDS55894.1. [Q8NFP9-3]
    PIRiT46310.
    RefSeqiNP_001191126.1. NM_001204197.1. [Q8NFP9-3]
    NP_056493.3. NM_015678.4. [Q8NFP9-1]
    UniGeneiHs.491172.

    Genome annotation databases

    EnsembliENST00000379922; ENSP00000369254; ENSG00000172915. [Q8NFP9-2]
    ENST00000400445; ENSP00000383295; ENSG00000172915. [Q8NFP9-1]
    ENST00000537702; ENSP00000440233; ENSG00000172915. [Q8NFP9-3]
    GeneIDi26960.
    KEGGihsa:26960.
    UCSCiuc001uvd.3. human. [Q8NFP9-2]
    uc010tee.1. human.
    uc021ric.1. human. [Q8NFP9-1]

    Polymorphism databases

    DMDMi296439289.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF467288 mRNA. Translation: AAM53531.1 .
    AL138690 Genomic DNA. No translation available.
    AK001059 mRNA. Translation: BAA91485.1 . Sequence problems.
    AK294737 mRNA. Translation: BAH11865.1 .
    AL139083 , AL390071 Genomic DNA. Translation: CAH71883.1 .
    AL159160 Genomic DNA. No translation available.
    AL161718 Genomic DNA. No translation available.
    AL161902 Genomic DNA. No translation available.
    AL356430 Genomic DNA. No translation available.
    AL357083 Genomic DNA. No translation available.
    AL390071 , AL139083 Genomic DNA. Translation: CAI17183.1 .
    AB046764 mRNA. Translation: BAB13370.1 .
    AL137748 mRNA. Translation: CAB70903.2 .
    AF072371 mRNA. Translation: AAD41633.1 . Frameshift.
    CCDSi CCDS45026.1. [Q8NFP9-1 ]
    CCDS55894.1. [Q8NFP9-3 ]
    PIRi T46310.
    RefSeqi NP_001191126.1. NM_001204197.1. [Q8NFP9-3 ]
    NP_056493.3. NM_015678.4. [Q8NFP9-1 ]
    UniGenei Hs.491172.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1MI1 X-ray 2.90 A/B 2150-2563 [» ]
    ProteinModelPortali Q8NFP9.
    SMRi Q8NFP9. Positions 2150-2563, 2692-2900.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117928. 6 interactions.
    IntActi Q8NFP9. 6 interactions.
    MINTi MINT-1380608.
    STRINGi 9606.ENSP00000383295.

    PTM databases

    PhosphoSitei Q8NFP9.

    Polymorphism databases

    DMDMi 296439289.

    Proteomic databases

    MaxQBi Q8NFP9.
    PRIDEi Q8NFP9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379922 ; ENSP00000369254 ; ENSG00000172915 . [Q8NFP9-2 ]
    ENST00000400445 ; ENSP00000383295 ; ENSG00000172915 . [Q8NFP9-1 ]
    ENST00000537702 ; ENSP00000440233 ; ENSG00000172915 . [Q8NFP9-3 ]
    GeneIDi 26960.
    KEGGi hsa:26960.
    UCSCi uc001uvd.3. human. [Q8NFP9-2 ]
    uc010tee.1. human.
    uc021ric.1. human. [Q8NFP9-1 ]

    Organism-specific databases

    CTDi 26960.
    GeneCardsi GC13P035516.
    H-InvDB HIX0029795.
    HGNCi HGNC:7648. NBEA.
    HPAi HPA039730.
    HPA040385.
    MIMi 604889. gene.
    neXtProti NX_Q8NFP9.
    PharmGKBi PA31454.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000082375.
    HOVERGENi HBG012582.
    InParanoidi Q8NFP9.
    PhylomeDBi Q8NFP9.
    TreeFami TF313490.

    Enzyme and pathway databases

    SignaLinki Q8NFP9.

    Miscellaneous databases

    ChiTaRSi NBEA. human.
    EvolutionaryTracei Q8NFP9.
    GenomeRNAii 26960.
    NextBioi 49420.
    PROi Q8NFP9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NFP9.
    Bgeei Q8NFP9.
    CleanExi HS_NBEA.
    Genevestigatori Q8NFP9.

    Family and domain databases

    Gene3Di 1.10.1540.10. 1 hit.
    2.130.10.10. 1 hit.
    2.30.29.40. 1 hit.
    2.60.120.200. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR000409. BEACH_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR010508. DUF1088.
    IPR023362. PH-BEACH_dom.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF02138. Beach. 1 hit.
    PF06469. DUF1088. 1 hit.
    PF14844. PH_BEACH. 1 hit.
    PF00400. WD40. 1 hit.
    [Graphical view ]
    SMARTi SM01026. Beach. 1 hit.
    SM00320. WD40. 5 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    SSF49899. SSF49899. 1 hit.
    SSF50978. SSF50978. 1 hit.
    SSF81837. SSF81837. 1 hit.
    PROSITEi PS50197. BEACH. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "BCL8 is a novel, evolutionarily conserved human gene family encoding proteins with presumptive protein kinase A anchoring function."
      Dyomin V.G., Chaganti S.R., Dyomina K., Palanisamy N., Murty V.V.V.S., Dalla-Favera R., Chaganti R.S.K.
      Genomics 80:158-165(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Brain1 Publication and Spleen1 Publication.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 606-1118 (ISOFORMS 1/2).
      Tissue: Brain and Embryonic head.
    3. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
      DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1919-2946 (ISOFORM 1).
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2393-2946 (ISOFORM 2).
      Tissue: Testis.
    6. "Identification of LYST2, a brain-specific member of the Chediak-Higashi syndrome gene family."
      Tchernev V.T., McMurtrie E.B., Nguyen Q.A., Mishra V.S., Barbosa M.D.F.S., McIndoe R., Kingsmore S.F.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2428-2946 (ISOFORM 1).
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain."
      Jogl G., Shen Y., Gebauer D., Li J., Wiegmann K., Kashkar H., Kroenke M., Tong L.
      EMBO J. 21:4785-4795(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 2150-2563.

    Entry informationi

    Entry nameiNBEA_HUMAN
    AccessioniPrimary (citable) accession number: Q8NFP9
    Secondary accession number(s): B7Z2H9
    , Q5T320, Q9HCM8, Q9NSU1, Q9NW98, Q9Y6J1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2003
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 130 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3