ID   GP156_HUMAN             Reviewed;         814 AA.
AC   Q8NFN8; B7ZL66; E9PFZ4; Q14CM1; Q86SN6;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   24-JAN-2024, entry version 146.
DE   RecName: Full=Probable G-protein coupled receptor 156;
DE   AltName: Full=G-protein coupled receptor PGR28;
DE   AltName: Full=GABAB-related G-protein coupled receptor;
GN   Name=GPR156; Synonyms=GABABL, PGR28;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND VARIANT
RP   ASP-516.
RX   PubMed=12591167; DOI=10.1016/s0169-328x(02)00662-9;
RA   Calver A.R., Michalovich D., Testa T.T., Robbins M.J., Jaillard C.,
RA   Hill J., Szekeres P.G., Charles K.J., Jourdain S., Holbrook J.D.,
RA   Boyfield I., Patel N., Medhurst A.D., Pangalos M.N.;
RT   "Molecular cloning and characterization of a novel GABA(B)-related G-
RT   protein coupled receptor.";
RL   Brain Res. Mol. Brain Res. 110:305-317(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP   ASP-516.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 138-330 (ISOFORM 1).
RX   PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA   Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA   Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA   Bergmann J.E., Gaitanaris G.A.;
RT   "The G protein-coupled receptor repertoires of human and mouse.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
CC   -!- FUNCTION: Orphan receptor.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8NFN8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8NFN8-2; Sequence=VSP_044603;
CC   -!- TISSUE SPECIFICITY: Ubiquitous expression both in the CNS and in
CC       peripheral tissues. Very high expression in fetal brain and testis
CC       relative to expression in other tissues. {ECO:0000269|PubMed:12591167}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC       receptor subfamily. {ECO:0000305}.
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DR   EMBL; AF488739; AAN03795.1; -; mRNA.
DR   EMBL; AC063952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC092897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC113701; AAI13702.1; -; mRNA.
DR   EMBL; BC143606; AAI43607.1; -; mRNA.
DR   EMBL; AY255565; AAO85077.1; -; mRNA.
DR   CCDS; CCDS2997.1; -. [Q8NFN8-1]
DR   CCDS; CCDS54629.1; -. [Q8NFN8-2]
DR   RefSeq; NP_001161743.1; NM_001168271.1. [Q8NFN8-2]
DR   RefSeq; NP_694547.2; NM_153002.2. [Q8NFN8-1]
DR   RefSeq; XP_005247222.1; XM_005247165.2.
DR   RefSeq; XP_016861284.1; XM_017005795.1. [Q8NFN8-1]
DR   RefSeq; XP_016861285.1; XM_017005796.1. [Q8NFN8-1]
DR   RefSeq; XP_016861286.1; XM_017005797.1.
DR   AlphaFoldDB; Q8NFN8; -.
DR   SMR; Q8NFN8; -.
DR   BioGRID; 127920; 75.
DR   IntAct; Q8NFN8; 69.
DR   STRING; 9606.ENSP00000417261; -.
DR   ChEMBL; CHEMBL4523897; -.
DR   TCDB; 9.A.14.15.4; the g-protein-coupled receptor (gpcr) family.
DR   GlyCosmos; Q8NFN8; 1 site, No reported glycans.
DR   GlyGen; Q8NFN8; 1 site.
DR   iPTMnet; Q8NFN8; -.
DR   PhosphoSitePlus; Q8NFN8; -.
DR   BioMuta; GPR156; -.
DR   DMDM; 296434518; -.
DR   PaxDb; 9606-ENSP00000417261; -.
DR   PeptideAtlas; Q8NFN8; -.
DR   ProteomicsDB; 20211; -.
DR   ProteomicsDB; 73328; -. [Q8NFN8-1]
DR   Antibodypedia; 32788; 102 antibodies from 23 providers.
DR   DNASU; 165829; -.
DR   Ensembl; ENST00000461057.1; ENSP00000418758.1; ENSG00000175697.11. [Q8NFN8-2]
DR   Ensembl; ENST00000464295.6; ENSP00000417261.1; ENSG00000175697.11. [Q8NFN8-1]
DR   GeneID; 165829; -.
DR   KEGG; hsa:165829; -.
DR   MANE-Select; ENST00000464295.6; ENSP00000417261.1; NM_153002.3; NP_694547.2.
DR   UCSC; uc011bjf.3; human. [Q8NFN8-1]
DR   AGR; HGNC:20844; -.
DR   CTD; 165829; -.
DR   GeneCards; GPR156; -.
DR   HGNC; HGNC:20844; GPR156.
DR   HPA; ENSG00000175697; Tissue enhanced (testis).
DR   MIM; 610464; gene.
DR   neXtProt; NX_Q8NFN8; -.
DR   OpenTargets; ENSG00000175697; -.
DR   PharmGKB; PA134918005; -.
DR   VEuPathDB; HostDB:ENSG00000175697; -.
DR   eggNOG; KOG1055; Eukaryota.
DR   GeneTree; ENSGT00940000159755; -.
DR   HOGENOM; CLU_350195_0_0_1; -.
DR   InParanoid; Q8NFN8; -.
DR   OMA; THFCASQ; -.
DR   OrthoDB; 5396723at2759; -.
DR   PhylomeDB; Q8NFN8; -.
DR   TreeFam; TF313965; -.
DR   PathwayCommons; Q8NFN8; -.
DR   SignaLink; Q8NFN8; -.
DR   BioGRID-ORCS; 165829; 18 hits in 1150 CRISPR screens.
DR   ChiTaRS; GPR156; human.
DR   GeneWiki; GPR156; -.
DR   GenomeRNAi; 165829; -.
DR   Pharos; Q8NFN8; Tdark.
DR   PRO; PR:Q8NFN8; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q8NFN8; Protein.
DR   Bgee; ENSG00000175697; Expressed in ventricular zone and 129 other cell types or tissues.
DR   ExpressionAtlas; Q8NFN8; baseline and differential.
DR   GO; GO:0038039; C:G protein-coupled receptor heterodimeric complex; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   GO; GO:0004965; F:G protein-coupled GABA receptor activity; IBA:GO_Central.
DR   GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IBA:GO_Central.
DR   CDD; cd15292; 7tmC_GPR156; 1.
DR   InterPro; IPR002455; GPCR3_GABA-B.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR041946; GPR156_7TM.
DR   PANTHER; PTHR10519:SF63; G-PROTEIN COUPLED RECEPTOR 156-RELATED; 1.
DR   PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   PRINTS; PR01176; GABABRECEPTR.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
DR   Genevisible; Q8NFN8; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell membrane; Coiled coil;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..814
FT                   /note="Probable G-protein coupled receptor 156"
FT                   /id="PRO_0000206899"
FT   TOPO_DOM        1..47
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        69..86
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        108..118
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        140..164
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        186..222
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        244..257
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        279..288
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        310..814
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          422..545
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          557..724
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          769..792
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          354..390
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        437..461
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        464..484
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        520..545
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        565..584
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        637..653
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        673..687
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        769..785
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        6
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         197..200
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_044603"
FT   VARIANT         516
FT                   /note="E -> D (in dbSNP:rs902790)"
FT                   /evidence="ECO:0000269|PubMed:12591167,
FT                   ECO:0000269|PubMed:15489334"
FT                   /id="VAR_049284"
SQ   SEQUENCE   814 AA;  89097 MW;  496B0654A26B4ADB CRC64;
     MEPEINCSEL CDSFPGQELD RRPLHDLCKT TITSSHHSSK TISSLSPVLL GIVWTFLSCG
     LLLILFFLAF TIHCRKNRIV KMSSPNLNIV TLLGSCLTYS SAYLFGIQDV LVGSSMETLI
     QTRLSMLCIG TSLVFGPILG KSWRLYKVFT QRVPDKRVII KDLQLLGLVA ALLMADVILL
     MTWVLTDPIQ CLQILSVSMT VTGKDVSCTS TSTHFCASRY SDVWIALIWG CKGLLLLYGA
     YLAGLTGHVS SPPVNQSLTI MVGVNLLVLA AGLLFVVTRY LHSWPNLVFG LTSGGIFVCT
     TTINCFIFIP QLKQWKAFEE ENQTIRRMAK YFSTPNKSFH TQYGEEENCH PRGEKSSMER
     LLTEKNAVIE SLQEQVNNAK EKIVRLMSAE CTYDLPEGAA PPASSPNKDV QAVASVHTLA
     AAQGPSGHLS DFQNDPGMAA RDSQCTSGPS SYAQSLEGPG KDSSFSPGKE EKISDSKDFS
     DHLDSGCSQK PWTEQSLGPE RGDQVPMNPS QSLLPERGGS DPQRQRHLEN SEEPPERRSR
     VSSVIREKLQ EVLQDLGLGP EASLSTAPSC HQQTWKNSAA FSPQKMPLSK ELGFSPYMVR
     RRRAAQRARS HFPGSAPSSV GHRANRTVPG AHSRLHVQNG DSPSLAPQTT DSRVRRPSSR
     KPSLPSDPQD RPGTLEGSKQ SQTEPEGARG SKAAFLRQPS GSGRAPSPAA PCLSKASPDL
     PEQWQLWPPV PSGCASLSSQ HSYFDTESSS SDEFFCRCHR PYCEICFQSS SDSSDSGTSD
     TDPEPTGGLA SWEKLWARSK PIVNFKDDLK PTLV
//