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Q8NFN8 (GP156_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 156
Alternative name(s):
G-protein coupled receptor PGR28
GABAB-related G-protein coupled receptor
Gene names
Name:GPR156
Synonyms:GABABL, PGR28
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length814 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Ubiquitous expression both in the CNS and in peripheral tissues. Very high expression in fetal brain and testis relative to expression in other tissues. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8NFN8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8NFN8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     197-200: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 814814Probable G-protein coupled receptor 156
PRO_0000206899

Regions

Topological domain1 – 4747Extracellular Potential
Transmembrane48 – 6821Helical; Potential
Topological domain69 – 8618Cytoplasmic Potential
Transmembrane87 – 10721Helical; Potential
Topological domain108 – 11811Extracellular Potential
Transmembrane119 – 13921Helical; Potential
Topological domain140 – 16425Cytoplasmic Potential
Transmembrane165 – 18521Helical; Potential
Topological domain186 – 22237Extracellular Potential
Transmembrane223 – 24321Helical; Potential
Topological domain244 – 25714Cytoplasmic Potential
Transmembrane258 – 27821Helical; Potential
Topological domain279 – 28810Extracellular Potential
Transmembrane289 – 30921Helical; Potential
Topological domain310 – 814505Cytoplasmic Potential
Coiled coil354 – 39037 Potential
Compositional bias600 – 6034Poly-Arg
Compositional bias748 – 7514Poly-Ser

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence197 – 2004Missing in isoform 2.
VSP_044603
Natural variant5161E → D. Ref.1 Ref.3
Corresponds to variant rs902790 [ dbSNP | Ensembl ].
VAR_049284

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 496B0654A26B4ADB

FASTA81489,097
        10         20         30         40         50         60 
MEPEINCSEL CDSFPGQELD RRPLHDLCKT TITSSHHSSK TISSLSPVLL GIVWTFLSCG 

        70         80         90        100        110        120 
LLLILFFLAF TIHCRKNRIV KMSSPNLNIV TLLGSCLTYS SAYLFGIQDV LVGSSMETLI 

       130        140        150        160        170        180 
QTRLSMLCIG TSLVFGPILG KSWRLYKVFT QRVPDKRVII KDLQLLGLVA ALLMADVILL 

       190        200        210        220        230        240 
MTWVLTDPIQ CLQILSVSMT VTGKDVSCTS TSTHFCASRY SDVWIALIWG CKGLLLLYGA 

       250        260        270        280        290        300 
YLAGLTGHVS SPPVNQSLTI MVGVNLLVLA AGLLFVVTRY LHSWPNLVFG LTSGGIFVCT 

       310        320        330        340        350        360 
TTINCFIFIP QLKQWKAFEE ENQTIRRMAK YFSTPNKSFH TQYGEEENCH PRGEKSSMER 

       370        380        390        400        410        420 
LLTEKNAVIE SLQEQVNNAK EKIVRLMSAE CTYDLPEGAA PPASSPNKDV QAVASVHTLA 

       430        440        450        460        470        480 
AAQGPSGHLS DFQNDPGMAA RDSQCTSGPS SYAQSLEGPG KDSSFSPGKE EKISDSKDFS 

       490        500        510        520        530        540 
DHLDSGCSQK PWTEQSLGPE RGDQVPMNPS QSLLPERGGS DPQRQRHLEN SEEPPERRSR 

       550        560        570        580        590        600 
VSSVIREKLQ EVLQDLGLGP EASLSTAPSC HQQTWKNSAA FSPQKMPLSK ELGFSPYMVR 

       610        620        630        640        650        660 
RRRAAQRARS HFPGSAPSSV GHRANRTVPG AHSRLHVQNG DSPSLAPQTT DSRVRRPSSR 

       670        680        690        700        710        720 
KPSLPSDPQD RPGTLEGSKQ SQTEPEGARG SKAAFLRQPS GSGRAPSPAA PCLSKASPDL 

       730        740        750        760        770        780 
PEQWQLWPPV PSGCASLSSQ HSYFDTESSS SDEFFCRCHR PYCEICFQSS SDSSDSGTSD 

       790        800        810 
TDPEPTGGLA SWEKLWARSK PIVNFKDDLK PTLV 

« Hide

Isoform 2 [UniParc].

Checksum: CB7A2A4E901E04D3
Show »

FASTA81088,679

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of a novel GABA(B)-related G-protein coupled receptor."
Calver A.R., Michalovich D., Testa T.T., Robbins M.J., Jaillard C., Hill J., Szekeres P.G., Charles K.J., Jourdain S., Holbrook J.D., Boyfield I., Patel N., Medhurst A.D., Pangalos M.N.
Brain Res. Mol. Brain Res. 110:305-317(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT ASP-516.
[2]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ASP-516.
Tissue: Brain.
[4]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 138-330 (ISOFORM 1).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF488739 mRNA. Translation: AAN03795.1.
AC063952 Genomic DNA. No translation available.
AC092897 Genomic DNA. No translation available.
BC113701 mRNA. Translation: AAI13702.1.
BC143606 mRNA. Translation: AAI43607.1.
AY255565 mRNA. Translation: AAO85077.1.
RefSeqNP_001161743.1. NM_001168271.1.
NP_694547.2. NM_153002.2.
XP_005247222.1. XM_005247165.1.
UniGeneHs.333358.

3D structure databases

ProteinModelPortalQ8NFN8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000324553.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NFN8.

Polymorphism databases

DMDM296434518.

Proteomic databases

PaxDbQ8NFN8.
PRIDEQ8NFN8.

Protocols and materials databases

DNASU165829.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000315843; ENSP00000324553; ENSG00000175697. [Q8NFN8-1]
ENST00000461057; ENSP00000418758; ENSG00000175697. [Q8NFN8-2]
ENST00000464295; ENSP00000417261; ENSG00000175697. [Q8NFN8-1]
GeneID165829.
KEGGhsa:165829.
UCSCuc011bjf.2. human. [Q8NFN8-1]

Organism-specific databases

CTD165829.
GeneCardsGC03M119883.
HGNCHGNC:20844. GPR156.
HPAHPA028642.
HPA028644.
MIM610464. gene.
neXtProtNX_Q8NFN8.
PharmGKBPA134918005.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG282946.
HOGENOMHOG000168413.
HOVERGENHBG081567.
InParanoidQ8NFN8.
KOK04617.
OMASWPNLVF.
OrthoDBEOG7BW0J0.
PhylomeDBQ8NFN8.
TreeFamTF313965.

Gene expression databases

ArrayExpressQ8NFN8.
BgeeQ8NFN8.
CleanExHS_GPR156.
GenevestigatorQ8NFN8.

Family and domain databases

InterProIPR017978. GPCR_3_C.
IPR002455. GPCR_3_GABA_rcpt_B.
[Graphical view]
PfamPF00003. 7tm_3. 1 hit.
[Graphical view]
PRINTSPR01176. GABABRECEPTR.
PROSITEPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR156.
GenomeRNAi165829.
NextBio88564.
PROQ8NFN8.
SOURCESearch...

Entry information

Entry nameGP156_HUMAN
AccessionPrimary (citable) accession number: Q8NFN8
Secondary accession number(s): B7ZL66 expand/collapse secondary AC list , E9PFZ4, Q14CM1, Q86SN6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: May 18, 2010
Last modified: March 19, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries