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Protein

Probable G-protein coupled receptor 156

Gene

GPR156

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 156
Alternative name(s):
G-protein coupled receptor PGR28
GABAB-related G-protein coupled receptor
Gene namesi
Name:GPR156
Synonyms:GABABL, PGR28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:20844. GPR156.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747ExtracellularSequence analysisAdd
BLAST
Transmembranei48 – 6821HelicalSequence analysisAdd
BLAST
Topological domaini69 – 8618CytoplasmicSequence analysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence analysisAdd
BLAST
Topological domaini108 – 11811ExtracellularSequence analysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence analysisAdd
BLAST
Topological domaini140 – 16425CytoplasmicSequence analysisAdd
BLAST
Transmembranei165 – 18521HelicalSequence analysisAdd
BLAST
Topological domaini186 – 22237ExtracellularSequence analysisAdd
BLAST
Transmembranei223 – 24321HelicalSequence analysisAdd
BLAST
Topological domaini244 – 25714CytoplasmicSequence analysisAdd
BLAST
Transmembranei258 – 27821HelicalSequence analysisAdd
BLAST
Topological domaini279 – 28810ExtracellularSequence analysis
Transmembranei289 – 30921HelicalSequence analysisAdd
BLAST
Topological domaini310 – 814505CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134918005.

Polymorphism and mutation databases

BioMutaiGPR156.
DMDMi296434518.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 814814Probable G-protein coupled receptor 156PRO_0000206899Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NFN8.
PRIDEiQ8NFN8.

PTM databases

iPTMnetiQ8NFN8.
PhosphoSiteiQ8NFN8.

Expressioni

Tissue specificityi

Ubiquitous expression both in the CNS and in peripheral tissues. Very high expression in fetal brain and testis relative to expression in other tissues.1 Publication

Gene expression databases

BgeeiQ8NFN8.
CleanExiHS_GPR156.
ExpressionAtlasiQ8NFN8. baseline and differential.
GenevisibleiQ8NFN8. HS.

Organism-specific databases

HPAiHPA028642.
HPA028644.

Interactioni

Protein-protein interaction databases

BioGridi127920. 69 interactions.
STRINGi9606.ENSP00000324553.

Structurei

3D structure databases

ProteinModelPortaliQ8NFN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili354 – 39037Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi600 – 6034Poly-Arg
Compositional biasi748 – 7514Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1055. Eukaryota.
ENOG410XNN1. LUCA.
GeneTreeiENSGT00530000063129.
HOGENOMiHOG000168413.
HOVERGENiHBG081567.
InParanoidiQ8NFN8.
KOiK04617.
OMAiCHRPYCE.
OrthoDBiEOG7BW0J0.
PhylomeDBiQ8NFN8.
TreeFamiTF313965.

Family and domain databases

InterProiIPR002455. GPCR3_GABA-B.
IPR017978. GPCR_3_C.
[Graphical view]
PANTHERiPTHR10519. PTHR10519. 1 hit.
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NFN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPEINCSEL CDSFPGQELD RRPLHDLCKT TITSSHHSSK TISSLSPVLL
60 70 80 90 100
GIVWTFLSCG LLLILFFLAF TIHCRKNRIV KMSSPNLNIV TLLGSCLTYS
110 120 130 140 150
SAYLFGIQDV LVGSSMETLI QTRLSMLCIG TSLVFGPILG KSWRLYKVFT
160 170 180 190 200
QRVPDKRVII KDLQLLGLVA ALLMADVILL MTWVLTDPIQ CLQILSVSMT
210 220 230 240 250
VTGKDVSCTS TSTHFCASRY SDVWIALIWG CKGLLLLYGA YLAGLTGHVS
260 270 280 290 300
SPPVNQSLTI MVGVNLLVLA AGLLFVVTRY LHSWPNLVFG LTSGGIFVCT
310 320 330 340 350
TTINCFIFIP QLKQWKAFEE ENQTIRRMAK YFSTPNKSFH TQYGEEENCH
360 370 380 390 400
PRGEKSSMER LLTEKNAVIE SLQEQVNNAK EKIVRLMSAE CTYDLPEGAA
410 420 430 440 450
PPASSPNKDV QAVASVHTLA AAQGPSGHLS DFQNDPGMAA RDSQCTSGPS
460 470 480 490 500
SYAQSLEGPG KDSSFSPGKE EKISDSKDFS DHLDSGCSQK PWTEQSLGPE
510 520 530 540 550
RGDQVPMNPS QSLLPERGGS DPQRQRHLEN SEEPPERRSR VSSVIREKLQ
560 570 580 590 600
EVLQDLGLGP EASLSTAPSC HQQTWKNSAA FSPQKMPLSK ELGFSPYMVR
610 620 630 640 650
RRRAAQRARS HFPGSAPSSV GHRANRTVPG AHSRLHVQNG DSPSLAPQTT
660 670 680 690 700
DSRVRRPSSR KPSLPSDPQD RPGTLEGSKQ SQTEPEGARG SKAAFLRQPS
710 720 730 740 750
GSGRAPSPAA PCLSKASPDL PEQWQLWPPV PSGCASLSSQ HSYFDTESSS
760 770 780 790 800
SDEFFCRCHR PYCEICFQSS SDSSDSGTSD TDPEPTGGLA SWEKLWARSK
810
PIVNFKDDLK PTLV
Length:814
Mass (Da):89,097
Last modified:May 18, 2010 - v2
Checksum:i496B0654A26B4ADB
GO
Isoform 2 (identifier: Q8NFN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-200: Missing.

Note: No experimental confirmation available.
Show »
Length:810
Mass (Da):88,679
Checksum:iCB7A2A4E901E04D3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti516 – 5161E → D.2 Publications
Corresponds to variant rs902790 [ dbSNP | Ensembl ].
VAR_049284

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei197 – 2004Missing in isoform 2. 1 PublicationVSP_044603

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF488739 mRNA. Translation: AAN03795.1.
AC063952 Genomic DNA. No translation available.
AC092897 Genomic DNA. No translation available.
BC113701 mRNA. Translation: AAI13702.1.
BC143606 mRNA. Translation: AAI43607.1.
AY255565 mRNA. Translation: AAO85077.1.
CCDSiCCDS2997.1. [Q8NFN8-1]
CCDS54629.1. [Q8NFN8-2]
RefSeqiNP_001161743.1. NM_001168271.1. [Q8NFN8-2]
NP_694547.2. NM_153002.2. [Q8NFN8-1]
XP_005247222.1. XM_005247165.1. [Q8NFN8-1]
XP_011510785.1. XM_011512483.1. [Q8NFN8-1]
UniGeneiHs.333358.

Genome annotation databases

EnsembliENST00000315843; ENSP00000324553; ENSG00000175697. [Q8NFN8-1]
ENST00000461057; ENSP00000418758; ENSG00000175697. [Q8NFN8-2]
ENST00000464295; ENSP00000417261; ENSG00000175697. [Q8NFN8-1]
GeneIDi165829.
KEGGihsa:165829.
UCSCiuc011bjf.3. human. [Q8NFN8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF488739 mRNA. Translation: AAN03795.1.
AC063952 Genomic DNA. No translation available.
AC092897 Genomic DNA. No translation available.
BC113701 mRNA. Translation: AAI13702.1.
BC143606 mRNA. Translation: AAI43607.1.
AY255565 mRNA. Translation: AAO85077.1.
CCDSiCCDS2997.1. [Q8NFN8-1]
CCDS54629.1. [Q8NFN8-2]
RefSeqiNP_001161743.1. NM_001168271.1. [Q8NFN8-2]
NP_694547.2. NM_153002.2. [Q8NFN8-1]
XP_005247222.1. XM_005247165.1. [Q8NFN8-1]
XP_011510785.1. XM_011512483.1. [Q8NFN8-1]
UniGeneiHs.333358.

3D structure databases

ProteinModelPortaliQ8NFN8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127920. 69 interactions.
STRINGi9606.ENSP00000324553.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NFN8.
PhosphoSiteiQ8NFN8.

Polymorphism and mutation databases

BioMutaiGPR156.
DMDMi296434518.

Proteomic databases

PaxDbiQ8NFN8.
PRIDEiQ8NFN8.

Protocols and materials databases

DNASUi165829.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315843; ENSP00000324553; ENSG00000175697. [Q8NFN8-1]
ENST00000461057; ENSP00000418758; ENSG00000175697. [Q8NFN8-2]
ENST00000464295; ENSP00000417261; ENSG00000175697. [Q8NFN8-1]
GeneIDi165829.
KEGGihsa:165829.
UCSCiuc011bjf.3. human. [Q8NFN8-1]

Organism-specific databases

CTDi165829.
GeneCardsiGPR156.
HGNCiHGNC:20844. GPR156.
HPAiHPA028642.
HPA028644.
MIMi610464. gene.
neXtProtiNX_Q8NFN8.
PharmGKBiPA134918005.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1055. Eukaryota.
ENOG410XNN1. LUCA.
GeneTreeiENSGT00530000063129.
HOGENOMiHOG000168413.
HOVERGENiHBG081567.
InParanoidiQ8NFN8.
KOiK04617.
OMAiCHRPYCE.
OrthoDBiEOG7BW0J0.
PhylomeDBiQ8NFN8.
TreeFamiTF313965.

Miscellaneous databases

ChiTaRSiGPR156. human.
GeneWikiiGPR156.
GenomeRNAii165829.
PROiQ8NFN8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NFN8.
CleanExiHS_GPR156.
ExpressionAtlasiQ8NFN8. baseline and differential.
GenevisibleiQ8NFN8. HS.

Family and domain databases

InterProiIPR002455. GPCR3_GABA-B.
IPR017978. GPCR_3_C.
[Graphical view]
PANTHERiPTHR10519. PTHR10519. 1 hit.
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT ASP-516.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ASP-516.
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 138-330 (ISOFORM 1).

Entry informationi

Entry nameiGP156_HUMAN
AccessioniPrimary (citable) accession number: Q8NFN8
Secondary accession number(s): B7ZL66
, E9PFZ4, Q14CM1, Q86SN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.