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Protein
Submitted name:

Adenylate cyclase type I

Gene

ADCY1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

LyaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
Adenylate cyclase type IImported (EC:4.6.1.1Imported)
Gene namesi
Name:ADCY1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei64 – 8320HelicalSequence analysisAdd
BLAST
Transmembranei95 – 11319HelicalSequence analysisAdd
BLAST
Transmembranei125 – 14218HelicalSequence analysisAdd
BLAST
Transmembranei162 – 17716HelicalSequence analysisAdd
BLAST
Transmembranei182 – 20221HelicalSequence analysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24560.

PTM / Processingi

Proteomic databases

PaxDbiQ8NFM5.
PRIDEiQ8NFM5.

Expressioni

Gene expression databases

BgeeiQ8NFM5.
GenevisibleiQ8NFM5. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000297323.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 283245AC_NInterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3619. Eukaryota.
COG2114. LUCA.
KOiK08041.

Family and domain databases

InterProiIPR032628. AC_N.
[Graphical view]
PfamiPF16214. AC_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8NFM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAPRGGGG GGGGAGEPGG AERAAGTSRR RGLRACDEEF ACPELEALFR
60 70 80 90 100
GYTLRLEQAA TLKALAVLSL LAGALALAEL LGAPGPAPGL AKGSHPVHCV
110 120 130 140 150
LFLALLVVTN VRSLQVPQLQ QVGQLALLFS LTFALLCCPF ALGGPARGSA
160 170 180 190 200
GAAGGPATAE QGVWQLLLVT FVSYALLPVR SLLAIGFGLV VAASHLLVTA
210 220 230 240 250
TLVPAKRPRL WRTLGANALL FVGVNMYGVF VRILTERSQR KAFLQARSCI
260 270 280 290 300
EDRLRLEDEN EKQERLLMSL LPRNVAMEMK EDFLKPPERI FHKIYIQRHD

N
Length:301
Mass (Da):32,063
Last modified:October 1, 2002 - v1
Checksum:i6AB95F1898F466C6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei301 – 3011Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF497515 mRNA. Translation: AAM94372.1.
RefSeqiNP_066939.1. NM_021116.2.
UniGeneiHs.192215.

Genome annotation databases

GeneIDi107.
KEGGihsa:107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF497515 mRNA. Translation: AAM94372.1.
RefSeqiNP_066939.1. NM_021116.2.
UniGeneiHs.192215.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000297323.

Proteomic databases

PaxDbiQ8NFM5.
PRIDEiQ8NFM5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi107.
KEGGihsa:107.

Organism-specific databases

CTDi107.
PharmGKBiPA24560.

Phylogenomic databases

eggNOGiKOG3619. Eukaryota.
COG2114. LUCA.
KOiK08041.

Miscellaneous databases

ChiTaRSiADCY1. human.
GenomeRNAii107.

Gene expression databases

BgeeiQ8NFM5.
GenevisibleiQ8NFM5. HS.

Family and domain databases

InterProiIPR032628. AC_N.
[Graphical view]
PfamiPF16214. AC_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms."
    Ludwig M.G., Seuwen K.
    J. Recept. Signal Transduct. 22:79-110(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Ludwig M.G., Seuwen K.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8NFM5_HUMAN
AccessioniPrimary (citable) accession number: Q8NFM5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.