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Q8NFM4

- ADCY4_HUMAN

UniProt

Q8NFM4 - ADCY4_HUMAN

Protein

Adenylate cyclase type 4

Gene

ADCY4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.By similarity

    Catalytic activityi

    ATP = 3',5'-cyclic AMP + diphosphate.

    Cofactori

    Binds 2 magnesium ions per subunit.By similarity

    Enzyme regulationi

    Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi278 – 2781Magnesium 1PROSITE-ProRule annotation
    Metal bindingi278 – 2781Magnesium 2PROSITE-ProRule annotation
    Metal bindingi279 – 2791Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
    Metal bindingi322 – 3221Magnesium 1PROSITE-ProRule annotation
    Metal bindingi322 – 3221Magnesium 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. adenylate cyclase activity Source: BHF-UCL
    2. ATP binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. nucleotide binding Source: UniProtKB-KW
    5. protein binding Source: UniProtKB

    GO - Biological processi

    1. activation of phospholipase C activity Source: Reactome
    2. activation of protein kinase A activity Source: Reactome
    3. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Reactome
    4. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Reactome
    5. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: UniProtKB
    6. cAMP biosynthetic process Source: BHF-UCL
    7. cellular response to glucagon stimulus Source: Reactome
    8. energy reserve metabolic process Source: Reactome
    9. epidermal growth factor receptor signaling pathway Source: Reactome
    10. fibroblast growth factor receptor signaling pathway Source: Reactome
    11. innate immune response Source: Reactome
    12. intracellular signal transduction Source: InterPro
    13. neurotrophin TRK receptor signaling pathway Source: Reactome
    14. signal transduction Source: Reactome
    15. small molecule metabolic process Source: Reactome
    16. synaptic transmission Source: Reactome
    17. transmembrane transport Source: Reactome
    18. water transport Source: Reactome

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_15312. Adenylate cyclase activating pathway.
    REACT_15333. Adenylate cyclase inhibitory pathway.
    REACT_15530. PKA activation.
    REACT_1665. Glucagon signaling in metabolic regulation.
    REACT_19231. G alpha (i) signalling events.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_1946. PKA activation in glucagon signalling.
    REACT_24023. Regulation of water balance by renal Aquaporins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase type 4 (EC:4.6.1.1)
    Alternative name(s):
    ATP pyrophosphate-lyase 4
    Adenylate cyclase type IV
    Adenylyl cyclase 4
    Gene namesi
    Name:ADCY4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:235. ADCY4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. dendrite Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. membrane Source: BHF-UCL
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24562.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10771077Adenylate cyclase type 4PRO_0000195690Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi697 – 6971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi704 – 7041N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8NFM4.
    PRIDEiQ8NFM4.

    PTM databases

    PhosphoSiteiQ8NFM4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NFM4.
    BgeeiQ8NFM4.
    CleanExiHS_ADCY4.
    GenevestigatoriQ8NFM4.

    Organism-specific databases

    HPAiCAB005070.

    Interactioni

    Protein-protein interaction databases

    BioGridi128229. 1 interaction.
    IntActiQ8NFM4. 4 interactions.
    STRINGi9606.ENSP00000312126.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NFM4.
    SMRiQ8NFM4. Positions 261-447, 864-1043.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini191 – 585395CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini688 – 71427ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini808 – 1077270CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 5022HelicalSequence AnalysisAdd
    BLAST
    Transmembranei61 – 8020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei94 – 11724HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 13819HelicalSequence AnalysisAdd
    BLAST
    Transmembranei141 – 16222HelicalSequence AnalysisAdd
    BLAST
    Transmembranei170 – 19021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei586 – 60722HelicalSequence AnalysisAdd
    BLAST
    Transmembranei611 – 63323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei664 – 68724HelicalSequence AnalysisAdd
    BLAST
    Transmembranei715 – 73622HelicalSequence AnalysisAdd
    BLAST
    Transmembranei744 – 76421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei791 – 80717HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
    Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2114.
    HOVERGENiHBG050458.
    InParanoidiQ8NFM4.
    KOiK08044.
    OMAiFLHSHAW.
    OrthoDBiEOG76X5ZC.
    PhylomeDBiQ8NFM4.
    TreeFamiTF313845.

    Family and domain databases

    Gene3Di3.30.70.1230. 2 hits.
    InterProiIPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR009398. Adenylate_cyclase-like.
    [Graphical view]
    PfamiPF06327. DUF1053. 1 hit.
    PF00211. Guanylate_cyc. 2 hits.
    [Graphical view]
    SMARTiSM00044. CYCc. 2 hits.
    [Graphical view]
    SUPFAMiSSF55073. SSF55073. 2 hits.
    PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NFM4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARLFSPRPP PSEDLFYETY YSLSQQYPLL LLLLGIVLCA LAALLAVAWA     50
    SGRELTSDPS FLTTVLCALG GFSLLLGLAS REQRLQRWTR PLSGLVWVAL 100
    LALGHAFLFT GGVVSAWDQV SYFLFVIFTA YAMLPLGMRD AAVAGLASSL 150
    SHLLVLGLYL GPQPDSRPAL LPQLAANAVL FLCGNVAGVY HKALMERALR 200
    ATFREALSSL HSRRRLDTEK KHQEHLLLSI LPAYLAREMK AEIMARLQAG 250
    QGSRPESTNN FHSLYVKRHQ GVSVLYADIV GFTRLASECS PKELVLMLNE 300
    LFGKFDQIAK EHECMRIKIL GDCYYCVSGL PLSLPDHAIN CVRMGLDMCR 350
    AIRKLRAATG VDINMRVGVH SGSVLCGVIG LQKWQYDVWS HDVTLANHME 400
    AGGVPGRVHI TGATLALLAG AYAVEDAGME HRDPYLRELG EPTYLVIDPR 450
    AEEEDEKGTA GGLLSSLEGL KMRPSLLMTR YLESWGAAKP FAHLSHGDSP 500
    VSTSTPLPEK TLASFSTQWS LDRSRTPRGL DDELDTGDAK FFQVIEQLNS 550
    QKQWKQSKDF NPLTLYFREK EMEKEYRLSA IPAFKYYEAC TFLVFLSNFI 600
    IQMLVTNRPP ALAITYSITF LLFLLILFVC FSEDLMRCVL KGPKMLHWLP 650
    ALSGLVATRP GLRIALGTAT ILLVFAMAIT SLFFFPTSSD CPFQAPNVSS 700
    MISNLSWELP GSLPLISVPY SMHCCTLGFL SCSLFLHMSF ELKLLLLLLW 750
    LAASCSLFLH SHAWLSECLI VRLYLGPLDS RPGVLKEPKL MGAISFFIFF 800
    FTLLVLARQN EYYCRLDFLW KKKLRQEREE TETMENLTRL LLENVLPAHV 850
    APQFIGQNRR NEDLYHQSYE CVCVLFASVP DFKEFYSESN INHEGLECLR 900
    LLNEIIADFD ELLSKPKFSG VEKIKTIGST YMAATGLNAT SGQDAQQDAE 950
    RSCSHLGTMV EFAVALGSKL DVINKHSFNN FRLRVGLNHG PVVAGVIGAQ 1000
    KPQYDIWGNT VNVASRMEST GVLGKIQVTE ETAWALQSLG YTCYSRGVIK 1050
    VKGKGQLCTY FLNTDLTRTG PPSATLG 1077
    Length:1,077
    Mass (Da):119,794
    Last modified:October 1, 2002 - v1
    Checksum:i24C0D5AE495CFD50
    GO
    Isoform 2 (identifier: Q8NFM4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-45: MARLFSPRPP...IVLCALAALL → MSRGTRESAC...SSLASSTRLP
         46-352: Missing.
         720-726: YSMHCCT → VSVPTCP
         727-1077: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:419
    Mass (Da):46,245
    Checksum:iCDBC2C78773CD634
    GO

    Sequence cautioni

    The sequence BAB71270.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti571 – 5711E → G in BAB71270. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4545MARLF…LAALL → MSRGTRESACCMLTSWASRG WPASVPLRSWCSCSMSSLAS STRLP in isoform 2. 1 PublicationVSP_055816Add
    BLAST
    Alternative sequencei46 – 352307Missing in isoform 2. 1 PublicationVSP_055817Add
    BLAST
    Alternative sequencei720 – 7267YSMHCCT → VSVPTCP in isoform 2. 1 PublicationVSP_055818
    Alternative sequencei727 – 1077351Missing in isoform 2. 1 PublicationVSP_055819Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF497516 mRNA. Translation: AAM94373.1.
    AK056745 mRNA. Translation: BAB71270.1. Different initiation.
    AK122714 mRNA. Translation: BAG53686.1.
    AK126468 mRNA. Translation: BAC86560.1.
    AL096870 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW66023.1.
    CH471078 Genomic DNA. Translation: EAW66026.1.
    CH471078 Genomic DNA. Translation: EAW66027.1.
    CH471078 Genomic DNA. Translation: EAW66028.1.
    BC117473 mRNA. Translation: AAI17474.1.
    BC117475 mRNA. Translation: AAI17476.1.
    CCDSiCCDS9627.1.
    RefSeqiNP_001185497.1. NM_001198568.1.
    NP_001185521.1. NM_001198592.1.
    NP_640340.2. NM_139247.3.
    UniGeneiHs.443428.

    Genome annotation databases

    EnsembliENST00000310677; ENSP00000312126; ENSG00000129467. [Q8NFM4-1]
    ENST00000418030; ENSP00000393177; ENSG00000129467. [Q8NFM4-1]
    ENST00000554068; ENSP00000452250; ENSG00000129467. [Q8NFM4-1]
    GeneIDi196883.
    KEGGihsa:196883.
    UCSCiuc001wow.3. human.

    Polymorphism databases

    DMDMi25008336.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF497516 mRNA. Translation: AAM94373.1 .
    AK056745 mRNA. Translation: BAB71270.1 . Different initiation.
    AK122714 mRNA. Translation: BAG53686.1 .
    AK126468 mRNA. Translation: BAC86560.1 .
    AL096870 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW66023.1 .
    CH471078 Genomic DNA. Translation: EAW66026.1 .
    CH471078 Genomic DNA. Translation: EAW66027.1 .
    CH471078 Genomic DNA. Translation: EAW66028.1 .
    BC117473 mRNA. Translation: AAI17474.1 .
    BC117475 mRNA. Translation: AAI17476.1 .
    CCDSi CCDS9627.1.
    RefSeqi NP_001185497.1. NM_001198568.1.
    NP_001185521.1. NM_001198592.1.
    NP_640340.2. NM_139247.3.
    UniGenei Hs.443428.

    3D structure databases

    ProteinModelPortali Q8NFM4.
    SMRi Q8NFM4. Positions 261-447, 864-1043.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128229. 1 interaction.
    IntActi Q8NFM4. 4 interactions.
    STRINGi 9606.ENSP00000312126.

    Chemistry

    BindingDBi Q8NFM4.
    ChEMBLi CHEMBL2097167.

    PTM databases

    PhosphoSitei Q8NFM4.

    Polymorphism databases

    DMDMi 25008336.

    Proteomic databases

    PaxDbi Q8NFM4.
    PRIDEi Q8NFM4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000310677 ; ENSP00000312126 ; ENSG00000129467 . [Q8NFM4-1 ]
    ENST00000418030 ; ENSP00000393177 ; ENSG00000129467 . [Q8NFM4-1 ]
    ENST00000554068 ; ENSP00000452250 ; ENSG00000129467 . [Q8NFM4-1 ]
    GeneIDi 196883.
    KEGGi hsa:196883.
    UCSCi uc001wow.3. human.

    Organism-specific databases

    CTDi 196883.
    GeneCardsi GC14M024787.
    HGNCi HGNC:235. ADCY4.
    HPAi CAB005070.
    MIMi 600292. gene.
    neXtProti NX_Q8NFM4.
    PharmGKBi PA24562.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2114.
    HOVERGENi HBG050458.
    InParanoidi Q8NFM4.
    KOi K08044.
    OMAi FLHSHAW.
    OrthoDBi EOG76X5ZC.
    PhylomeDBi Q8NFM4.
    TreeFami TF313845.

    Enzyme and pathway databases

    Reactomei REACT_15312. Adenylate cyclase activating pathway.
    REACT_15333. Adenylate cyclase inhibitory pathway.
    REACT_15530. PKA activation.
    REACT_1665. Glucagon signaling in metabolic regulation.
    REACT_19231. G alpha (i) signalling events.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_1946. PKA activation in glucagon signalling.
    REACT_24023. Regulation of water balance by renal Aquaporins.

    Miscellaneous databases

    GeneWikii ADCY4.
    GenomeRNAii 196883.
    NextBioi 89574.
    PROi Q8NFM4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NFM4.
    Bgeei Q8NFM4.
    CleanExi HS_ADCY4.
    Genevestigatori Q8NFM4.

    Family and domain databases

    Gene3Di 3.30.70.1230. 2 hits.
    InterProi IPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR009398. Adenylate_cyclase-like.
    [Graphical view ]
    Pfami PF06327. DUF1053. 1 hit.
    PF00211. Guanylate_cyc. 2 hits.
    [Graphical view ]
    SMARTi SM00044. CYCc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55073. SSF55073. 2 hits.
    PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms."
      Ludwig M.G., Seuwen K.
      J. Recept. Signal Transduct. 22:79-110(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Spleen.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Placenta, Tongue and Uterus.
    3. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.

    Entry informationi

    Entry nameiADCY4_HUMAN
    AccessioniPrimary (citable) accession number: Q8NFM4
    Secondary accession number(s): B3KV74
    , D3DS75, Q17R40, Q6ZTM6, Q96ML7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3