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Protein

Adenylate cyclase type 4

Gene

ADCY4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.By similarity

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Enzyme regulationi

Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi278 – 2781Magnesium 1PROSITE-ProRule annotation
Metal bindingi278 – 2781Magnesium 2PROSITE-ProRule annotation
Metal bindingi279 – 2791Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi322 – 3221Magnesium 1PROSITE-ProRule annotation
Metal bindingi322 – 3221Magnesium 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. adenylate cyclase activity Source: BHF-UCL
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. activation of phospholipase C activity Source: Reactome
  2. activation of protein kinase A activity Source: Reactome
  3. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Reactome
  4. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Reactome
  5. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: UniProtKB
  6. cAMP biosynthetic process Source: BHF-UCL
  7. cellular response to glucagon stimulus Source: Reactome
  8. energy reserve metabolic process Source: Reactome
  9. epidermal growth factor receptor signaling pathway Source: Reactome
  10. fibroblast growth factor receptor signaling pathway Source: Reactome
  11. innate immune response Source: Reactome
  12. intracellular signal transduction Source: InterPro
  13. neurotrophin TRK receptor signaling pathway Source: Reactome
  14. renal water homeostasis Source: Reactome
  15. signal transduction Source: Reactome
  16. small molecule metabolic process Source: Reactome
  17. synaptic transmission Source: Reactome
  18. transmembrane transport Source: Reactome
  19. water transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_15312. Adenylate cyclase activating pathway.
REACT_15333. Adenylate cyclase inhibitory pathway.
REACT_15530. PKA activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_19231. G alpha (i) signalling events.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_1946. PKA activation in glucagon signalling.
REACT_24023. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_268323. Hedgehog 'off' state.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase type 4 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 4
Adenylate cyclase type IV
Adenylyl cyclase 4
Gene namesi
Name:ADCY4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:235. ADCY4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei29 – 5022HelicalSequence AnalysisAdd
BLAST
Transmembranei61 – 8020HelicalSequence AnalysisAdd
BLAST
Transmembranei94 – 11724HelicalSequence AnalysisAdd
BLAST
Transmembranei120 – 13819HelicalSequence AnalysisAdd
BLAST
Transmembranei141 – 16222HelicalSequence AnalysisAdd
BLAST
Transmembranei170 – 19021HelicalSequence AnalysisAdd
BLAST
Topological domaini191 – 585395CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei586 – 60722HelicalSequence AnalysisAdd
BLAST
Transmembranei611 – 63323HelicalSequence AnalysisAdd
BLAST
Transmembranei664 – 68724HelicalSequence AnalysisAdd
BLAST
Topological domaini688 – 71427ExtracellularSequence AnalysisAdd
BLAST
Transmembranei715 – 73622HelicalSequence AnalysisAdd
BLAST
Transmembranei744 – 76421HelicalSequence AnalysisAdd
BLAST
Transmembranei791 – 80717HelicalSequence AnalysisAdd
BLAST
Topological domaini808 – 1077270CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. dendrite Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane Source: BHF-UCL
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24562.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10771077Adenylate cyclase type 4PRO_0000195690Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi697 – 6971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi704 – 7041N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NFM4.
PRIDEiQ8NFM4.

PTM databases

PhosphoSiteiQ8NFM4.

Expressioni

Gene expression databases

BgeeiQ8NFM4.
CleanExiHS_ADCY4.
ExpressionAtlasiQ8NFM4. baseline and differential.
GenevestigatoriQ8NFM4.

Organism-specific databases

HPAiCAB005070.
HPA048344.

Interactioni

Protein-protein interaction databases

BioGridi128229. 2 interactions.
IntActiQ8NFM4. 4 interactions.
STRINGi9606.ENSP00000312126.

Structurei

3D structure databases

ProteinModelPortaliQ8NFM4.
SMRiQ8NFM4. Positions 261-447, 864-1043.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00760000119042.
HOGENOMiHOG000143645.
HOVERGENiHBG050458.
InParanoidiQ8NFM4.
KOiK08044.
OMAiFLHSHAW.
OrthoDBiEOG76X5ZC.
PhylomeDBiQ8NFM4.
TreeFamiTF313845.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adcy_conserved_dom.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NFM4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARLFSPRPP PSEDLFYETY YSLSQQYPLL LLLLGIVLCA LAALLAVAWA
60 70 80 90 100
SGRELTSDPS FLTTVLCALG GFSLLLGLAS REQRLQRWTR PLSGLVWVAL
110 120 130 140 150
LALGHAFLFT GGVVSAWDQV SYFLFVIFTA YAMLPLGMRD AAVAGLASSL
160 170 180 190 200
SHLLVLGLYL GPQPDSRPAL LPQLAANAVL FLCGNVAGVY HKALMERALR
210 220 230 240 250
ATFREALSSL HSRRRLDTEK KHQEHLLLSI LPAYLAREMK AEIMARLQAG
260 270 280 290 300
QGSRPESTNN FHSLYVKRHQ GVSVLYADIV GFTRLASECS PKELVLMLNE
310 320 330 340 350
LFGKFDQIAK EHECMRIKIL GDCYYCVSGL PLSLPDHAIN CVRMGLDMCR
360 370 380 390 400
AIRKLRAATG VDINMRVGVH SGSVLCGVIG LQKWQYDVWS HDVTLANHME
410 420 430 440 450
AGGVPGRVHI TGATLALLAG AYAVEDAGME HRDPYLRELG EPTYLVIDPR
460 470 480 490 500
AEEEDEKGTA GGLLSSLEGL KMRPSLLMTR YLESWGAAKP FAHLSHGDSP
510 520 530 540 550
VSTSTPLPEK TLASFSTQWS LDRSRTPRGL DDELDTGDAK FFQVIEQLNS
560 570 580 590 600
QKQWKQSKDF NPLTLYFREK EMEKEYRLSA IPAFKYYEAC TFLVFLSNFI
610 620 630 640 650
IQMLVTNRPP ALAITYSITF LLFLLILFVC FSEDLMRCVL KGPKMLHWLP
660 670 680 690 700
ALSGLVATRP GLRIALGTAT ILLVFAMAIT SLFFFPTSSD CPFQAPNVSS
710 720 730 740 750
MISNLSWELP GSLPLISVPY SMHCCTLGFL SCSLFLHMSF ELKLLLLLLW
760 770 780 790 800
LAASCSLFLH SHAWLSECLI VRLYLGPLDS RPGVLKEPKL MGAISFFIFF
810 820 830 840 850
FTLLVLARQN EYYCRLDFLW KKKLRQEREE TETMENLTRL LLENVLPAHV
860 870 880 890 900
APQFIGQNRR NEDLYHQSYE CVCVLFASVP DFKEFYSESN INHEGLECLR
910 920 930 940 950
LLNEIIADFD ELLSKPKFSG VEKIKTIGST YMAATGLNAT SGQDAQQDAE
960 970 980 990 1000
RSCSHLGTMV EFAVALGSKL DVINKHSFNN FRLRVGLNHG PVVAGVIGAQ
1010 1020 1030 1040 1050
KPQYDIWGNT VNVASRMEST GVLGKIQVTE ETAWALQSLG YTCYSRGVIK
1060 1070
VKGKGQLCTY FLNTDLTRTG PPSATLG
Length:1,077
Mass (Da):119,794
Last modified:October 1, 2002 - v1
Checksum:i24C0D5AE495CFD50
GO
Isoform 2 (identifier: Q8NFM4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: MARLFSPRPP...IVLCALAALL → MSRGTRESAC...SSLASSTRLP
     46-352: Missing.
     720-726: YSMHCCT → VSVPTCP
     727-1077: Missing.

Note: No experimental confirmation available.

Show »
Length:419
Mass (Da):46,245
Checksum:iCDBC2C78773CD634
GO

Sequence cautioni

The sequence BAB71270.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti571 – 5711E → G in BAB71270 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4545MARLF…LAALL → MSRGTRESACCMLTSWASRG WPASVPLRSWCSCSMSSLAS STRLP in isoform 2. 1 PublicationVSP_055816Add
BLAST
Alternative sequencei46 – 352307Missing in isoform 2. 1 PublicationVSP_055817Add
BLAST
Alternative sequencei720 – 7267YSMHCCT → VSVPTCP in isoform 2. 1 PublicationVSP_055818
Alternative sequencei727 – 1077351Missing in isoform 2. 1 PublicationVSP_055819Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF497516 mRNA. Translation: AAM94373.1.
AK056745 mRNA. Translation: BAB71270.1. Different initiation.
AK122714 mRNA. Translation: BAG53686.1.
AK126468 mRNA. Translation: BAC86560.1.
AL096870 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66023.1.
CH471078 Genomic DNA. Translation: EAW66026.1.
CH471078 Genomic DNA. Translation: EAW66027.1.
CH471078 Genomic DNA. Translation: EAW66028.1.
BC117473 mRNA. Translation: AAI17474.1.
BC117475 mRNA. Translation: AAI17476.1.
CCDSiCCDS9627.1. [Q8NFM4-1]
RefSeqiNP_001185497.1. NM_001198568.1. [Q8NFM4-1]
NP_001185521.1. NM_001198592.1. [Q8NFM4-1]
NP_640340.2. NM_139247.3. [Q8NFM4-1]
UniGeneiHs.443428.

Genome annotation databases

EnsembliENST00000310677; ENSP00000312126; ENSG00000129467. [Q8NFM4-1]
ENST00000418030; ENSP00000393177; ENSG00000129467. [Q8NFM4-1]
ENST00000554068; ENSP00000452250; ENSG00000129467. [Q8NFM4-1]
GeneIDi196883.
KEGGihsa:196883.
UCSCiuc001wow.3. human. [Q8NFM4-1]

Polymorphism databases

DMDMi25008336.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF497516 mRNA. Translation: AAM94373.1.
AK056745 mRNA. Translation: BAB71270.1. Different initiation.
AK122714 mRNA. Translation: BAG53686.1.
AK126468 mRNA. Translation: BAC86560.1.
AL096870 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66023.1.
CH471078 Genomic DNA. Translation: EAW66026.1.
CH471078 Genomic DNA. Translation: EAW66027.1.
CH471078 Genomic DNA. Translation: EAW66028.1.
BC117473 mRNA. Translation: AAI17474.1.
BC117475 mRNA. Translation: AAI17476.1.
CCDSiCCDS9627.1. [Q8NFM4-1]
RefSeqiNP_001185497.1. NM_001198568.1. [Q8NFM4-1]
NP_001185521.1. NM_001198592.1. [Q8NFM4-1]
NP_640340.2. NM_139247.3. [Q8NFM4-1]
UniGeneiHs.443428.

3D structure databases

ProteinModelPortaliQ8NFM4.
SMRiQ8NFM4. Positions 261-447, 864-1043.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128229. 2 interactions.
IntActiQ8NFM4. 4 interactions.
STRINGi9606.ENSP00000312126.

Chemistry

ChEMBLiCHEMBL2097167.

PTM databases

PhosphoSiteiQ8NFM4.

Polymorphism databases

DMDMi25008336.

Proteomic databases

PaxDbiQ8NFM4.
PRIDEiQ8NFM4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310677; ENSP00000312126; ENSG00000129467. [Q8NFM4-1]
ENST00000418030; ENSP00000393177; ENSG00000129467. [Q8NFM4-1]
ENST00000554068; ENSP00000452250; ENSG00000129467. [Q8NFM4-1]
GeneIDi196883.
KEGGihsa:196883.
UCSCiuc001wow.3. human. [Q8NFM4-1]

Organism-specific databases

CTDi196883.
GeneCardsiGC14M024787.
HGNCiHGNC:235. ADCY4.
HPAiCAB005070.
HPA048344.
MIMi600292. gene.
neXtProtiNX_Q8NFM4.
PharmGKBiPA24562.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00760000119042.
HOGENOMiHOG000143645.
HOVERGENiHBG050458.
InParanoidiQ8NFM4.
KOiK08044.
OMAiFLHSHAW.
OrthoDBiEOG76X5ZC.
PhylomeDBiQ8NFM4.
TreeFamiTF313845.

Enzyme and pathway databases

ReactomeiREACT_15312. Adenylate cyclase activating pathway.
REACT_15333. Adenylate cyclase inhibitory pathway.
REACT_15530. PKA activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_19231. G alpha (i) signalling events.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_1946. PKA activation in glucagon signalling.
REACT_24023. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_268323. Hedgehog 'off' state.

Miscellaneous databases

GeneWikiiADCY4.
GenomeRNAii196883.
NextBioi89574.
PROiQ8NFM4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NFM4.
CleanExiHS_ADCY4.
ExpressionAtlasiQ8NFM4. baseline and differential.
GenevestigatoriQ8NFM4.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adcy_conserved_dom.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms."
    Ludwig M.G., Seuwen K.
    J. Recept. Signal Transduct. 22:79-110(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Spleen.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta, Tongue and Uterus.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.

Entry informationi

Entry nameiADCY4_HUMAN
AccessioniPrimary (citable) accession number: Q8NFM4
Secondary accession number(s): B3KV74
, D3DS75, Q17R40, Q6ZTM6, Q96ML7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: April 1, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.