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Reviewed, UniProtKB/Swiss-Prot Q8NFM4 (ADCY4_HUMAN)

Last modified January 19, 2010. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Adenylate cyclase type 4
    EC=4.6.1.1
Alternative name(s):
    Adenylate cyclase type IV
    ATP pyrophosphate-lyase 4
    Adenylyl cyclase 4
Gene names
Name: ADCY4
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length1077 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

This is a membrane-bound, calmodulin-insensitive adenylyl cyclase By similarity.

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactor

Binds 2 magnesium ions per subunit By similarity.

Enzyme regulation

Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 2 guanylate cyclase domains.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10771077Adenylate cyclase type 4
PRO_0000195690

Regions

Topological domain1 – 2828Cytoplasmic Potential
Transmembrane29 – 5022 Potential
Transmembrane61 – 8020 Potential
Transmembrane94 – 11724 Potential
Transmembrane120 – 13819 Potential
Transmembrane141 – 16222 Potential
Transmembrane170 – 19021 Potential
Topological domain191 – 585395Cytoplasmic Potential
Transmembrane586 – 60722 Potential
Transmembrane611 – 63323 Potential
Transmembrane664 – 68724 Potential
Topological domain688 – 71427Extracellular Potential
Transmembrane715 – 73622 Potential
Transmembrane744 – 76421 Potential
Transmembrane791 – 80717 Potential
Topological domain808 – 1077270Cytoplasmic Potential

Sites

Metal binding2781Magnesium 1 By similarity
Metal binding2781Magnesium 2 By similarity
Metal binding2791Magnesium 2; via carbonyl oxygen By similarity
Metal binding3221Magnesium 1 By similarity
Metal binding3221Magnesium 2 By similarity

Amino acid modifications

Glycosylation6971N-linked (GlcNAc...) Potential
Glycosylation7041N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict5711E → G Ref.4

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Sequences

Sequence LengthMass (Da)Tools
Q8NFM4-1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 24C0D5AE495CFD50

FASTA1,077119,794
        10         20         30         40         50         60 
MARLFSPRPP PSEDLFYETY YSLSQQYPLL LLLLGIVLCA LAALLAVAWA SGRELTSDPS 

        70         80         90        100        110        120 
FLTTVLCALG GFSLLLGLAS REQRLQRWTR PLSGLVWVAL LALGHAFLFT GGVVSAWDQV 

       130        140        150        160        170        180 
SYFLFVIFTA YAMLPLGMRD AAVAGLASSL SHLLVLGLYL GPQPDSRPAL LPQLAANAVL 

       190        200        210        220        230        240 
FLCGNVAGVY HKALMERALR ATFREALSSL HSRRRLDTEK KHQEHLLLSI LPAYLAREMK 

       250        260        270        280        290        300 
AEIMARLQAG QGSRPESTNN FHSLYVKRHQ GVSVLYADIV GFTRLASECS PKELVLMLNE 

       310        320        330        340        350        360 
LFGKFDQIAK EHECMRIKIL GDCYYCVSGL PLSLPDHAIN CVRMGLDMCR AIRKLRAATG 

       370        380        390        400        410        420 
VDINMRVGVH SGSVLCGVIG LQKWQYDVWS HDVTLANHME AGGVPGRVHI TGATLALLAG 

       430        440        450        460        470        480 
AYAVEDAGME HRDPYLRELG EPTYLVIDPR AEEEDEKGTA GGLLSSLEGL KMRPSLLMTR 

       490        500        510        520        530        540 
YLESWGAAKP FAHLSHGDSP VSTSTPLPEK TLASFSTQWS LDRSRTPRGL DDELDTGDAK 

       550        560        570        580        590        600 
FFQVIEQLNS QKQWKQSKDF NPLTLYFREK EMEKEYRLSA IPAFKYYEAC TFLVFLSNFI 

       610        620        630        640        650        660 
IQMLVTNRPP ALAITYSITF LLFLLILFVC FSEDLMRCVL KGPKMLHWLP ALSGLVATRP 

       670        680        690        700        710        720 
GLRIALGTAT ILLVFAMAIT SLFFFPTSSD CPFQAPNVSS MISNLSWELP GSLPLISVPY 

       730        740        750        760        770        780 
SMHCCTLGFL SCSLFLHMSF ELKLLLLLLW LAASCSLFLH SHAWLSECLI VRLYLGPLDS 

       790        800        810        820        830        840 
RPGVLKEPKL MGAISFFIFF FTLLVLARQN EYYCRLDFLW KKKLRQEREE TETMENLTRL 

       850        860        870        880        890        900 
LLENVLPAHV APQFIGQNRR NEDLYHQSYE CVCVLFASVP DFKEFYSESN INHEGLECLR 

       910        920        930        940        950        960 
LLNEIIADFD ELLSKPKFSG VEKIKTIGST YMAATGLNAT SGQDAQQDAE RSCSHLGTMV 

       970        980        990       1000       1010       1020 
EFAVALGSKL DVINKHSFNN FRLRVGLNHG PVVAGVIGAQ KPQYDIWGNT VNVASRMEST 

      1030       1040       1050       1060       1070 
GVLGKIQVTE ETAWALQSLG YTCYSRGVIK VKGKGQLCTY FLNTDLTRTG PPSATLG

« Hide

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References

« Hide 'large scale' references
[1]"Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms."
Ludwig M.G., Seuwen K.
J. Recept. Signal Transduct. 22:79-110(2002) [PubMed: 12503609] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Spleen.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta and Tongue.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF497516 mRNA. Translation: AAM94373.1.
AK056745 mRNA. Translation: BAB71270.1. Different initiation.
AK122714 mRNA. Translation: BAG53686.1.
CH471078 Genomic DNA. Translation: EAW66023.1.
BC117473 mRNA. Translation: AAI17474.1.
BC117475 mRNA. Translation: AAI17476.1.
IPIIPI00465156.
RefSeqNP_640340.2.
UniGeneHs.443428

3D structure databases

SMRQ8NFM4. Positions 261-447, 865-1064.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8NFM4.

PTM databases

PhosphoSiteQ8NFM4.

Proteomic databases

PRIDEQ8NFM4.

Genome annotation databases

EnsemblENST00000310677; ENSP00000312126; ENSG00000129467; Homo sapiens. [Genome view]
ENST00000418030; ENSP00000393177; ENSG00000129467; Homo sapiens. [Genome view]
GeneID196883.
KEGGhsa:196883.
UCSCuc001wov.1. human.

Organism-specific databases

CTD196883.
GeneCardsGC14M023857.
H-InvDBHIX0011571.
HGNCHGNC:235. ADCY4.
HPACAB005070.
MIM600292. gene.
PharmGKBPA24562.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG08999.
HOVERGENQ8NFM4.
InParanoidQ8NFM4.
OMASCSLFLH.
OrthoDBEOG9S4S1S.
PhylomeDBQ8NFM4.

Enzyme and pathway databases

BRENDA4.6.1.1. 247.
Pathway_Interaction_DBendothelinpathway. Endothelins.
lysophospholipid_pathway. LPA receptor mediated events.
lpa4_pathway. LPA4-mediated signaling events.
ReactomeREACT_11061. Signalling by NGF.
REACT_14797. Signaling by GPCR.
REACT_1505. Integration of energy metabolism.
REACT_15295. Opioid Signalling.

Gene expression databases

ArrayExpressQ8NFM4.
BgeeQ8NFM4.
CleanExHS_ADCY4.
GenevestigatorQ8NFM4.
GermOnlineENSG00000129467. Homo sapiens.

Family and domain databases

InterProIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Aden_cycl-like.
[Graphical view]
Gene3DG3DSA:3.30.70.1230. A/G_cyclase. 2 hits.
PfamPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTSM00044. CYCc. 2 hits.
[Graphical view]
PROSITEPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio89574.
SOURCESearch...

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Entry information

Entry nameADCY4_HUMAN
AccessionPrimary (citable) accession number: Q8NFM4
Secondary accession number(s): B3KV74, Q17R40, Q96ML7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: January 19, 2010
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents