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Protein

Gap junction gamma-3 protein

Gene

GJC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176402-MONOMER.

Protein family/group databases

TCDBi1.A.24.1.7. the gap junction-forming connexin (connexin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction gamma-3 protein
Alternative name(s):
Connexin-30.2
Short name:
Cx30.2
Connexin-31.3
Short name:
Cx31.3
Gap junction epsilon-1 protein
Gene namesi
Name:GJC3
Synonyms:GJE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:17495. GJC3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Topological domaini44 – 75ExtracellularSequence analysisAdd BLAST32
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 132CytoplasmicSequence analysisAdd BLAST36
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Topological domaini154 – 194ExtracellularSequence analysisAdd BLAST41
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 279CytoplasmicSequence analysisAdd BLAST64

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi349149.
OpenTargetsiENSG00000176402.
PharmGKBiPA162389705.

Polymorphism and mutation databases

BioMutaiGJC3.
DMDMi32171365.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578741 – 279Gap junction gamma-3 proteinAdd BLAST279

Proteomic databases

PaxDbiQ8NFK1.
PeptideAtlasiQ8NFK1.
PRIDEiQ8NFK1.

PTM databases

iPTMnetiQ8NFK1.
PhosphoSitePlusiQ8NFK1.

Expressioni

Tissue specificityi

CNS specific. Expression is restricted to brain, spinal cord, and sciatic nerve. According to PubMed:12881038, expression is abundant in skeletal muscle, liver, and heart, and to a minor degree in pancreas and kidney.2 Publications

Gene expression databases

BgeeiENSG00000176402.
CleanExiHS_GJC3.

Organism-specific databases

HPAiHPA015024.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000325775.

Structurei

3D structure databases

ProteinModelPortaliQ8NFK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Gamma-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8Q3. Eukaryota.
ENOG4111D69. LUCA.
GeneTreeiENSGT00860000133694.
HOGENOMiHOG000231127.
HOVERGENiHBG107788.
InParanoidiQ8NFK1.
KOiK07628.
OMAiIFLKTMF.
OrthoDBiEOG091G06LA.
PhylomeDBiQ8NFK1.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NFK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGRFLRRLL AEESRRSTPV GRLLLPVLLG FRLVLLAASG PGVYGDEQSE
60 70 80 90 100
FVCHTQQPGC KAACFDAFHP LSPLRFWVFQ VILVAVPSAL YMGFTLYHVI
110 120 130 140 150
WHWELSGKGK EEETLIQGRE GNTDVPGAGS LRLLWAYVAQ LGARLVLEGA
160 170 180 190 200
ALGLQYHLYG FQMPSSFACR REPCLGSITC NLSRPSEKTI FLKTMFGVSG
210 220 230 240 250
FCLLFTFLEL VLLGLGRWWR TWKHKSSSSK YFLTSESTRR HKKATDSLPV
260 270
VETKEQFQEA VPGRSLAQEK QRPVGPRDA
Length:279
Mass (Da):31,299
Last modified:October 1, 2002 - v1
Checksum:i71810BB8E30533BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503615 mRNA. Translation: AAM21145.1.
AY297109 mRNA. Translation: AAP51161.1.
CH236956 Genomic DNA. Translation: EAL23863.1.
CH471091 Genomic DNA. Translation: EAW76624.1.
BC043381 mRNA. Translation: AAH43381.1.
CCDSiCCDS34697.1.
RefSeqiNP_853516.1. NM_181538.2.
UniGeneiHs.647524.

Genome annotation databases

EnsembliENST00000312891; ENSP00000325775; ENSG00000176402.
GeneIDi349149.
KEGGihsa:349149.
UCSCiuc011kjd.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503615 mRNA. Translation: AAM21145.1.
AY297109 mRNA. Translation: AAP51161.1.
CH236956 Genomic DNA. Translation: EAL23863.1.
CH471091 Genomic DNA. Translation: EAW76624.1.
BC043381 mRNA. Translation: AAH43381.1.
CCDSiCCDS34697.1.
RefSeqiNP_853516.1. NM_181538.2.
UniGeneiHs.647524.

3D structure databases

ProteinModelPortaliQ8NFK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000325775.

Protein family/group databases

TCDBi1.A.24.1.7. the gap junction-forming connexin (connexin) family.

PTM databases

iPTMnetiQ8NFK1.
PhosphoSitePlusiQ8NFK1.

Polymorphism and mutation databases

BioMutaiGJC3.
DMDMi32171365.

Proteomic databases

PaxDbiQ8NFK1.
PeptideAtlasiQ8NFK1.
PRIDEiQ8NFK1.

Protocols and materials databases

DNASUi349149.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312891; ENSP00000325775; ENSG00000176402.
GeneIDi349149.
KEGGihsa:349149.
UCSCiuc011kjd.2. human.

Organism-specific databases

CTDi349149.
DisGeNETi349149.
GeneCardsiGJC3.
HGNCiHGNC:17495. GJC3.
HPAiHPA015024.
MIMi611925. gene.
neXtProtiNX_Q8NFK1.
OpenTargetsiENSG00000176402.
PharmGKBiPA162389705.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J8Q3. Eukaryota.
ENOG4111D69. LUCA.
GeneTreeiENSGT00860000133694.
HOGENOMiHOG000231127.
HOVERGENiHBG107788.
InParanoidiQ8NFK1.
KOiK07628.
OMAiIFLKTMF.
OrthoDBiEOG091G06LA.
PhylomeDBiQ8NFK1.
TreeFamiTF329606.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176402-MONOMER.

Miscellaneous databases

GeneWikiiGJC3.
GenomeRNAii349149.
PROiQ8NFK1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176402.
CleanExiHS_GJC3.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXG3_HUMAN
AccessioniPrimary (citable) accession number: Q8NFK1
Secondary accession number(s): A4D296, Q86XI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.