Q8NFJ9 (BBS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bardet-Biedl syndrome 1 protein

Alternative name(s):
BBS2-like protein 2

Gene names

Name:	BBS1
Synonyms:	BBS2L2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	593 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Ref.5
Subunit structure	Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8, BBS9 and BBIP10. The BBSome complex binds to PCM1 and tubulin. Interacts with the C-terminus of RAB3IP. Interacts with CCDC28B. Ref.4 Ref.5
Subcellular location	Cell projection › cilium membrane. Cytoplasm. Note: Localizes to nonmembranous centriolar satellites in the cytoplasm. Ref.5
Tissue specificity	Highly expressed in the kidney. Also found in fetal tissue, testis, retina, adipose tissue, heart, skeletal muscle and pancreas.
Involvement in disease	Ciliary dysfunction leads to a broad spectrum of disorders, collectively termed ciliopathies. Overlapping clinical features include retinal degeneration, renal cystic disease, skeletal abnormalities, fibrosis of various organ, and a complex range of anatomical and functional defects of the central and peripheral nervous system. The ciliopathy range of diseases includes Meckel-Gruber syndrome, Bardet-Biedl syndrome, Joubert syndrome, nephronophtisis, Senior-Loken syndrome, and Jeune asphyxiating thoracic dystrophy among others. Single-locus allelism is insufficient to explain the variable penetrance and expressivity of such disorders, leading to the suggestion that variations across multiple sites of the ciliary proteome, including BBS1, influence the clinical outcome. Bardet-Biedl syndrome 1 (BBS1) [MIM:209900]: A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.1 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13

Ontologies

Keywords
Biological process	Sensory transduction Vision
Cellular component	Cell membrane Cell projection Cilium Cytoplasm Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Bardet-Biedl syndrome Ciliopathy Disease mutation Mental retardation Obesity
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Golgi to plasma membrane protein transport Inferred from mutant phenotype PubMed 19150989. Source: MGI nonmotile primary cilium assembly Inferred from mutant phenotype PubMed 17980398. Source: BHF-UCL photoreceptor cell maintenance Inferred from mutant phenotype PubMed 17980398. Source: BHF-UCL response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW retina homeostasis Inferred from mutant phenotype PubMed 17980398. Source: BHF-UCL
Cellular_component	BBSome Inferred from direct assay Ref.5. Source: BHF-UCL cilium membrane Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ALDOB	P05062	4	EBI-1805484,EBI-1045507
ARL6	Q9H0F7	4	EBI-1805484,EBI-2891949
BBS2	Q9BXC9	6	EBI-1805484,EBI-748297
BBS4	Q96RK4	5	EBI-1805484,EBI-1805814
BBS7	Q8IWZ6	6	EBI-1805484,EBI-1806001
BBS9	Q3SYG4	6	EBI-1805484,EBI-2826852
EEF1A1	P68104	3	EBI-1805484,EBI-352162
Lepr	P48356-1	3	EBI-1805484,EBI-6143588	From a different organism.
PCM1	Q15154	2	EBI-1805484,EBI-741421
RAB3IP	Q96QF0-1	2	EBI-1805484,EBI-747860

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NFJ9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 3 (identifier: Q8NFJ9-2)

Also known as: DPP3-BBS1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MAAASSSDSDACGAES → MDPSWRRSSHSWPQPMPDSGRAPVRPHLAKLEEDVWPCPQFHQTKAASGPPFV

Note: Based on a readthrough transcript which may produce a DPP3-BBS1 fusion protein. No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 593	593	Bardet-Biedl syndrome 1 protein		PRO_0000064841
Natural variations
	Alternative sequence	1 – 16	16	MAAAS…CGAES → MDPSWRRSSHSWPQPMPDSG RAPVRPHLAKLEEDVWPCPQ FHQTKAASGPPFV in isoform 3.		VSP_008854
	Natural variant	35	1	H → R in BBS1. Ref.9		VAR_038880
	Natural variant	53	1	K → E in BBS1. Ref.9		VAR_038881
	Natural variant	148	1	D → N in BBS1. Ref.9		VAR_038882
	Natural variant	160	1	R → Q in BBS1. Ref.11 Ref.13		VAR_038883
	Natural variant	200 – 201	2	Missing in BBS1.		VAR_017214
	Natural variant	206	1	L → V in a patient with Bardet-Biedl syndrome. Ref.12		VAR_066485
	Natural variant	234	1	E → K in BBS1. Ref.8 Ref.9 Corresponds to variant rs35520756 [ dbSNP | Ensembl ].		VAR_017215
	Natural variant	245	1	P → L in a patient with Bardet-Biedl syndrome. Ref.12		VAR_066486
	Natural variant	305	1	G → S in BBS1. Ref.9		VAR_038884
	Natural variant	330	1	I → T in BBS1. Ref.13		VAR_066278
	Natural variant	389	1	Missing in BBS1. Ref.9		VAR_038885
	Natural variant	390	1	M → R in BBS1. Ref.1 Ref.7 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13		VAR_017216
	Natural variant	434	1	Y → S in BBS1. Ref.9		VAR_038886
	Natural variant	503	1	L → H in BBS1. Ref.9		VAR_038887
	Natural variant	518	1	L → P in BBS1. Ref.7 Ref.10		VAR_017217
	Natural variant	518	1	L → Q in BBS1. Ref.9		VAR_038888
	Natural variant	524	1	Missing in BBS1. Ref.13		VAR_066279
	Natural variant	559	1	G → D in a patient with Meckel-Gruber like syndrome also carrying L-753 in TTC21B and a variant in CC2D2A. Ref.6		VAR_065554

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 94C0C05667FE582D	FASTA	593	65,083
	10 20 30 40 50 60 MAAASSSDSD ACGAESNEAN SKWLDAHYDP MANIHTFSAC LALADLHGDG EYKLVVGDLG 70 80 90 100 110 120 PGGQQPRLKV LKGPLVMTES PLPALPAAAA TFLMEQHEPR TPALALASGP CVYVYKNLRP 130 140 150 160 170 180 YFKFSLPQLP PNPLEQDLWN QAKEDRIDPL TLKEMLESIR ETAEEPLSIQ SLRFLQLELS 190 200 210 220 230 240 EMEAFVNQHK SNSIKRQTVI TTMTTLKKNL ADEDAVSCLV LGTENKELLV LDPEAFTILA 250 260 270 280 290 300 KMSLPSVPVF LEVSGQFDVE FRLAAACRNG NIYILRRDSK HPKYCIELSA QPVGLIRVHK 310 320 330 340 350 360 VLVVGSTQDS LHGFTHKGKK LWTVQMPAAI LTMNLLEQHS RGLQAVMAGL ANGEVRIYRD 370 380 390 400 410 420 KALLNVIHTP DAVTSLCFGR YGREDNTLIM TTRGGGLIIK ILKRTAVFVE GGSEVGPPPA 430 440 450 460 470 480 QAMKLNVPRK TRLYVDQTLR EREAGTAMHR AFQTDLYLLR LRAARAYLQA LESSLSPLST 490 500 510 520 530 540 TAREPLKLHA VVQGLGPTFK LTLHLQNTST TRPVLGLLVC FLYNEALYSL PRAFFKVPLL 550 560 570 580 590 VPGLNYPLET FVESLSNKGI SDIIKVLVLR EGQSAPLLSA HVNMPGSEGL AAA
	Isoform 3 (DPP3-BBS1) [UniParc]. Checksum: 0226F9D57F35804D	FASTA	630	69,658
	10 20 30 40 50 60 MDPSWRRSSH SWPQPMPDSG RAPVRPHLAK LEEDVWPCPQ FHQTKAASGP PFVNEANSKW 70 80 90 100 110 120 LDAHYDPMAN IHTFSACLAL ADLHGDGEYK LVVGDLGPGG QQPRLKVLKG PLVMTESPLP 130 140 150 160 170 180 ALPAAAATFL MEQHEPRTPA LALASGPCVY VYKNLRPYFK FSLPQLPPNP LEQDLWNQAK 190 200 210 220 230 240 EDRIDPLTLK EMLESIRETA EEPLSIQSLR FLQLELSEME AFVNQHKSNS IKRQTVITTM 250 260 270 280 290 300 TTLKKNLADE DAVSCLVLGT ENKELLVLDP EAFTILAKMS LPSVPVFLEV SGQFDVEFRL 310 320 330 340 350 360 AAACRNGNIY ILRRDSKHPK YCIELSAQPV GLIRVHKVLV VGSTQDSLHG FTHKGKKLWT 370 380 390 400 410 420 VQMPAAILTM NLLEQHSRGL QAVMAGLANG EVRIYRDKAL LNVIHTPDAV TSLCFGRYGR 430 440 450 460 470 480 EDNTLIMTTR GGGLIIKILK RTAVFVEGGS EVGPPPAQAM KLNVPRKTRL YVDQTLRERE 490 500 510 520 530 540 AGTAMHRAFQ TDLYLLRLRA ARAYLQALES SLSPLSTTAR EPLKLHAVVQ GLGPTFKLTL 550 560 570 580 590 600 HLQNTSTTRP VLGLLVCFLY NEALYSLPRA FFKVPLLVPG LNYPLETFVE SLSNKGISDI 610 620 630 IKVLVLREGQ SAPLLSAHVN MPGSEGLAAA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of the gene (BBS1) most commonly involved in Bardet-Biedl syndrome, a complex human obesity syndrome." Mykytyn K., Nishimura D.Y., Searby C.C., Shastri M., Yen H., Beck J.S., Braun T., Streb L.M., Cornier A.S., Cox G.F., Fulton A.B., Carmi R., Lueleci G., Chandrasekharappa S.C., Collins F.S., Jacobson S.G., Heckenlively J.R., Weleber R.G., Stone E.M., Sheffield V.C. Nat. Genet. 31:435-438(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT BBS1 ARG-390.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"Dissection of epistasis in oligogenic Bardet-Biedl syndrome." Badano J.L., Leitch C.C., Ansley S.J., May-Simera H., Lawson S., Lewis R.A., Beales P.L., Dietz H.C., Fisher S., Katsanis N. Nature 439:326-330(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CCDC28B.
[5]	"A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis." Nachury M.V., Loktev A.V., Zhang Q., Westlake C.J., Peraenen J., Merdes A., Slusarski D.C., Scheller R.H., Bazan J.F., Sheffield V.C., Jackson P.K. Cell 129:1201-1213(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBUNIT, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RAB3IP.
[6]	"TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum." Davis E.E., Zhang Q., Liu Q., Diplas B.H., Davey L.M., Hartley J., Stoetzel C., Szymanska K., Ramaswami G., Logan C.V., Muzny D.M., Young A.C., Wheeler D.A., Cruz P., Morgan M., Lewis L.R., Cherukuri P., Maskeri B. , Hansen N.F., Mullikin J.C., Blakesley R.W., Bouffard G.G., Gyapay G., Rieger S., Tonshoff B., Kern I., Soliman N.A., Neuhaus T.J., Swoboda K.J., Kayserili H., Gallagher T.E., Lewis R.A., Bergmann C., Otto E.A., Saunier S., Scambler P.J., Beales P.L., Gleeson J.G., Maher E.R., Attie-Bitach T., Dollfus H., Johnson C.A., Green E.D., Gibbs R.A., Hildebrandt F., Pierce E.A., Katsanis N. Nat. Genet. 43:189-196(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN CILIOPATHIES, VARIANT ASP-559.
[7]	"Evaluation of complex inheritance involving the most common Bardet-Biedl syndrome locus (BBS1)." Mykytyn K., Nishimura D.Y., Searby C.C., Beck G., Bugge K., Haines H.L., Cornier A.S., Cox G.F., Fulton A.B., Carmi R., Iannaccone A., Jacobson S.G., Weleber R.G., Wright A.F., Riise R., Hennekam R.C.M., Lueleci G., Berker-Karauzum S. , Biesecker L.G., Stone E.M., Sheffield V.C. Am. J. Hum. Genet. 72:429-437(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS BBS1 200-ILE-THR-201 DEL; ARG-390 AND PRO-518.
[8]	"Identification of a novel Bardet-Biedl syndrome protein, BBS7, that shares structural features with BBS1 and BBS2." Badano J.L., Ansley S.J., Leitch C.C., Lewis R.A., Lupski J.R., Katsanis N. Am. J. Hum. Genet. 72:650-658(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT BBS1 LYS-234.
[9]	"Genetic interaction of BBS1 mutations with alleles at other BBS loci can result in non-Mendelian Bardet-Biedl syndrome." Beales P.L., Badano J.L., Ross A.J., Ansley S.J., Hoskins B.E., Kirsten B., Mein C.A., Froguel P., Scambler P.J., Lewis R.A., Lupski J.R., Katsanis N. Am. J. Hum. Genet. 72:1187-1199(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS BBS1 ARG-35; GLU-53; ASN-148; LYS-234; SER-305; ILE-389 DEL; ARG-390; SER-434 HIS-503 AND GLN-518.
[10]	"Further support for digenic inheritance in Bardet-Biedl syndrome." Fauser S., Munz M., Besch D. J. Med. Genet. 40:E104-E104(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS BBS1 ARG-390 AND PRO-518.
[11]	"Testing for triallelism: analysis of six BBS genes in a Bardet-Biedl syndrome family cohort." Hichri H., Stoetzel C., Laurier V., Caron S., Sigaudy S., Sarda P., Hamel C., Martin-Coignard D., Gilles M., Leheup B., Holder M., Kaplan J., Bitoun P., Lacombe D., Verloes A., Bonneau D., Perrin-Schmitt F., Brandt C. , Besancon A.-F., Mandel J.-L., Cossee M., Dollfus H. Eur. J. Hum. Genet. 13:607-616(2005) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS BBS1 GLN-160 AND ARG-390.
[12]	"Mutation analysis in Bardet-Biedl syndrome by DNA pooling and massively parallel resequencing in 105 individuals." Janssen S., Ramaswami G., Davis E.E., Hurd T., Airik R., Kasanuki J.M., Van Der Kraak L., Allen S.J., Beales P.L., Katsanis N., Otto E.A., Hildebrandt F. Hum. Genet. 129:79-90(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS VAL-206 AND LEU-245, VARIANT BBS1 ARG-390.
[13]	"BBS genotype-phenotype assessment of a multiethnic patient cohort calls for a revision of the disease definition." Deveault C., Billingsley G., Duncan J.L., Bin J., Theal R., Vincent A., Fieggen K.J., Gerth C., Noordeh N., Traboulsi E.I., Fishman G.A., Chitayat D., Knueppel T., Millan J.M., Munier F.L., Kennedy D., Jacobson S.G., Innes A.M. , Mitchell G.A., Boycott K., Heon E. Hum. Mutat. 32:610-619(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS BBS1 GLN-160; THR-330; ARG-390 AND ASN-524 DEL.
+	Additional computationally mapped references.

Web resources

Mutations of the BBS1 gene

Retina International's Scientific Newsletter

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF503941 mRNA. Translation: AAM92770.1. AK027645 mRNA. Translation: BAB55261.1. BC109064 mRNA. Translation: AAI09065.1.
IPI	IPI00045840. IPI00334007.
RefSeq	NP_078925.3. NM_024649.4.
UniGene	Hs.502915.
3D structure databases
ProteinModelPortal	Q8NFJ9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NFJ9. 30 interactions.
STRING	9606.ENSP00000353701.
PTM databases
PhosphoSite	Q8NFJ9.
Polymorphism databases
DMDM	38257662.
Proteomic databases
PaxDb	Q8NFJ9.
PRIDE	Q8NFJ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000318312; ENSP00000317469; ENSG00000174483.
GeneID	582.
KEGG	hsa:582.
UCSC	uc001oii.1. human. uc001oij.1. human.
Organism-specific databases
CTD	582.
GeneCards	GC11P066276.
HGNC	HGNC:966. BBS1.
MIM	209900. phenotype. 209901. gene.
neXtProt	NX_Q8NFJ9.
Orphanet	110. Bardet-Biedl syndrome.
PharmGKB	PA25275.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG84787.
HOGENOM	HOG000260890.
HOVERGEN	HBG045407.
InParanoid	Q8NFJ9.
KO	K16746.
OMA	SCLVIGT.
Gene expression databases
ArrayExpress	Q8NFJ9.
Bgee	Q8NFJ9.
CleanEx	HS_BBS1.
Genevestigator	Q8NFJ9.
GermOnline	ENSG00000174483. Homo sapiens.
Family and domain databases
InterPro	IPR011047. Quinonprotein_ADH-like_supfam. [Graphical view]
SUPFAM	SSF50998. Quin_alc_DH_like. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	582.
NextBio	2383.
SOURCE	Search...

Entry information

Entry name

BBS1_HUMAN

Accession

Primary (citable) accession number: Q8NFJ9
Secondary accession number(s): Q32MN0, Q96SN4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.