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Protein

Prokineticin receptor 2

Gene

PROKR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prokineticin receptor 2
Short name:
PK-R2
Alternative name(s):
G-protein coupled receptor 73-like 1
GPR73b
GPRg2
Gene namesi
Name:PROKR2
Synonyms:GPR73L1, PKR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15836. PROKR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5454ExtracellularSequence AnalysisAdd
BLAST
Transmembranei55 – 7521Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini76 – 8914CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei90 – 11021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini111 – 13626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei137 – 15721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini158 – 17114CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei172 – 19221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini193 – 22331ExtracellularSequence AnalysisAdd
BLAST
Transmembranei224 – 24421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini245 – 27329CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei274 – 29421Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini295 – 31319ExtracellularSequence AnalysisAdd
BLAST
Transmembranei314 – 33421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini335 – 38450CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Hypogonadotropic hypogonadism 3 with or without anosmia (HH3)6 Publications

The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in PROKR2 as well as in other HH-associated genes including KAL1, SEMA3A, PROK2, GNRH1 and FGFR1 (PubMed:17054399, PubMed:22927827, PubMed:23643382).

Disease descriptionA disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).

See also OMIM:244200
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851R → C in HH3; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; decreased signaling activity. 4 Publications
VAR_030957
Natural varianti85 – 851R → H in HH3; decreased signaling activity. 3 Publications
Corresponds to variant rs74315418 [ dbSNP | Ensembl ].
VAR_030958
Natural varianti113 – 1131Y → H in HH3. 1 Publication
VAR_072173
Natural varianti115 – 1151V → M in HH3; phenotype consistent with Kallmann syndrome. 2 Publications
VAR_069964
Natural varianti158 – 1581V → I in HH3; phenotype consistent with Kallmann syndrome. 1 Publication
VAR_072978
Natural varianti164 – 1641R → Q in HH3; phenotype consistent with Kallmann syndrome; decreased signaling activity. 3 Publications
VAR_030959
Natural varianti173 – 1731L → R in HH3; phenotype consistent with Kallmann syndrome; decreased signaling activity. 4 Publications
Corresponds to variant rs74315416 [ dbSNP | Ensembl ].
VAR_030960
Natural varianti178 – 1781W → S in HH3; decreased signaling activity. 3 Publications
Corresponds to variant rs201835496 [ dbSNP | Ensembl ].
VAR_030961
Natural varianti188 – 1881S → L in HH3. 1 Publication
VAR_072174
Natural varianti202 – 2021S → G in HH3; triallelic inheritance; the patient also carries mutations in GNRH1 and FGFR1. 1 Publication
VAR_069965
Natural varianti210 – 2101Q → R in HH3; phenotype consistent with Kallmann syndrome; decreased signaling activity; abolished ligand binding. 2 Publications
VAR_030962
Natural varianti248 – 2481R → Q in HH3. 1 Publication
VAR_072175
Natural varianti268 – 2681R → C in HH3; uncertain pathological significance; signaling activity is impaired. 3 Publications
Corresponds to variant rs78861628 [ dbSNP | Ensembl ].
VAR_030963
Natural varianti290 – 2901P → S in HH3; phenotype consistent with Kallmann syndrome; signaling activity is impaired; impaired cell surface-targeting. 3 Publications
VAR_030964
Natural varianti323 – 3231M → I in HH3; phenotype consistent with Kallmann syndrome; signaling activity is impaired. 2 Publications
VAR_030965
Natural varianti331 – 3311V → M in HH3; uncertain pathological significance. 4 Publications
VAR_030966
Natural varianti334 – 3341V → M in HH3; phenotype consistent with Kallmann syndrome. 1 Publication
VAR_072979
Natural varianti357 – 3571R → W in HH3. 1 Publication
VAR_072176

Keywords - Diseasei

Disease mutation, Hypogonadotropic hypogonadism, Kallmann syndrome

Organism-specific databases

MIMi244200. phenotype.
Orphaneti478. Kallmann syndrome.
432. Normosmic congenital hypogonadotropic hypogonadism.
3157. Septo-optic dysplasia.
PharmGKBiPA30014.

Polymorphism and mutation databases

BioMutaiPROKR2.
DMDMi33112425.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Prokineticin receptor 2PRO_0000070083Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi128 ↔ 208PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NFJ6.
PRIDEiQ8NFJ6.

PTM databases

PhosphoSiteiQ8NFJ6.

Expressioni

Tissue specificityi

Expressed in the ileocecum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary and brain.

Gene expression databases

BgeeiQ8NFJ6.
CleanExiHS_PROKR2.
GenevisibleiQ8NFJ6. HS.

Organism-specific databases

HPAiHPA047281.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi126143. 1 interaction.
STRINGi9606.ENSP00000217270.

Structurei

3D structure databases

ProteinModelPortaliQ8NFJ6.
SMRiQ8NFJ6. Positions 51-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG319668.
GeneTreeiENSGT00770000120614.
HOGENOMiHOG000231664.
HOVERGENiHBG039631.
InParanoidiQ8NFJ6.
KOiK08380.
OMAiDYDLPMD.
OrthoDBiEOG73NG3D.
PhylomeDBiQ8NFJ6.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NFJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQNGNTSF TPNFNPPQDH ASSLSFNFSY GDYDLPMDED EDMTKTRTFF
60 70 80 90 100
AAKIVIGIAL AGIMLVCGIG NFVFIAALTR YKKLRNLTNL LIANLAISDF
110 120 130 140 150
LVAIICCPFE MDYYVVRQLS WEHGHVLCAS VNYLRTVSLY VSTNALLAIA
160 170 180 190 200
IDRYLAIVHP LKPRMNYQTA SFLIALVWMV SILIAIPSAY FATETVLFIV
210 220 230 240 250
KSQEKIFCGQ IWPVDQQLYY KSYFLFIFGV EFVGPVVTMT LCYARISREL
260 270 280 290 300
WFKAVPGFQT EQIRKRLRCR RKTVLVLMCI LTAYVLCWAP FYGFTIVRDF
310 320 330 340 350
FPTVFVKEKH YLTAFYVVEC IAMSNSMINT VCFVTVKNNT MKYFKKMMLL
360 370 380
HWRPSQRGSK SSADLDLRTN GVPTTEEVDC IRLK
Length:384
Mass (Da):43,996
Last modified:October 1, 2002 - v1
Checksum:i2D5BFA3655347B5E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851R → C in HH3; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; decreased signaling activity. 4 Publications
VAR_030957
Natural varianti85 – 851R → H in HH3; decreased signaling activity. 3 Publications
Corresponds to variant rs74315418 [ dbSNP | Ensembl ].
VAR_030958
Natural varianti113 – 1131Y → H in HH3. 1 Publication
VAR_072173
Natural varianti115 – 1151V → M in HH3; phenotype consistent with Kallmann syndrome. 2 Publications
VAR_069964
Natural varianti158 – 1581V → I in HH3; phenotype consistent with Kallmann syndrome. 1 Publication
VAR_072978
Natural varianti164 – 1641R → Q in HH3; phenotype consistent with Kallmann syndrome; decreased signaling activity. 3 Publications
VAR_030959
Natural varianti173 – 1731L → R in HH3; phenotype consistent with Kallmann syndrome; decreased signaling activity. 4 Publications
Corresponds to variant rs74315416 [ dbSNP | Ensembl ].
VAR_030960
Natural varianti178 – 1781W → S in HH3; decreased signaling activity. 3 Publications
Corresponds to variant rs201835496 [ dbSNP | Ensembl ].
VAR_030961
Natural varianti188 – 1881S → L in HH3. 1 Publication
VAR_072174
Natural varianti202 – 2021S → G in HH3; triallelic inheritance; the patient also carries mutations in GNRH1 and FGFR1. 1 Publication
VAR_069965
Natural varianti210 – 2101Q → R in HH3; phenotype consistent with Kallmann syndrome; decreased signaling activity; abolished ligand binding. 2 Publications
VAR_030962
Natural varianti248 – 2481R → Q in HH3. 1 Publication
VAR_072175
Natural varianti268 – 2681R → C in HH3; uncertain pathological significance; signaling activity is impaired. 3 Publications
Corresponds to variant rs78861628 [ dbSNP | Ensembl ].
VAR_030963
Natural varianti290 – 2901P → S in HH3; phenotype consistent with Kallmann syndrome; signaling activity is impaired; impaired cell surface-targeting. 3 Publications
VAR_030964
Natural varianti323 – 3231M → I in HH3; phenotype consistent with Kallmann syndrome; signaling activity is impaired. 2 Publications
VAR_030965
Natural varianti331 – 3311V → M in HH3; uncertain pathological significance. 4 Publications
VAR_030966
Natural varianti334 – 3341V → M in HH3; phenotype consistent with Kallmann syndrome. 1 Publication
VAR_072979
Natural varianti335 – 3351T → M.1 Publication
VAR_030967
Natural varianti357 – 3571R → W in HH3. 1 Publication
VAR_072176

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF506288 mRNA. Translation: AAM48128.1.
AB084081 mRNA. Translation: BAC24022.1.
EF577398 mRNA. Translation: ABQ52418.1.
AL121755 Genomic DNA. Translation: CAI22379.1.
BC104959 mRNA. Translation: AAI04960.1.
BC104961 mRNA. Translation: AAI04962.1.
CCDSiCCDS13089.1.
RefSeqiNP_658986.1. NM_144773.2.
XP_005260720.1. XM_005260663.2.
UniGeneiHs.375029.

Genome annotation databases

EnsembliENST00000217270; ENSP00000217270; ENSG00000101292.
GeneIDi128674.
KEGGihsa:128674.
UCSCiuc010zqw.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF506288 mRNA. Translation: AAM48128.1.
AB084081 mRNA. Translation: BAC24022.1.
EF577398 mRNA. Translation: ABQ52418.1.
AL121755 Genomic DNA. Translation: CAI22379.1.
BC104959 mRNA. Translation: AAI04960.1.
BC104961 mRNA. Translation: AAI04962.1.
CCDSiCCDS13089.1.
RefSeqiNP_658986.1. NM_144773.2.
XP_005260720.1. XM_005260663.2.
UniGeneiHs.375029.

3D structure databases

ProteinModelPortaliQ8NFJ6.
SMRiQ8NFJ6. Positions 51-367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126143. 1 interaction.
STRINGi9606.ENSP00000217270.

Chemistry

BindingDBiQ8NFJ6.
ChEMBLiCHEMBL5548.
GuidetoPHARMACOLOGYi336.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NFJ6.

Polymorphism and mutation databases

BioMutaiPROKR2.
DMDMi33112425.

Proteomic databases

PaxDbiQ8NFJ6.
PRIDEiQ8NFJ6.

Protocols and materials databases

DNASUi128674.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217270; ENSP00000217270; ENSG00000101292.
GeneIDi128674.
KEGGihsa:128674.
UCSCiuc010zqw.2. human.

Organism-specific databases

CTDi128674.
GeneCardsiGC20M005282.
GeneReviewsiPROKR2.
HGNCiHGNC:15836. PROKR2.
HPAiHPA047281.
MIMi244200. phenotype.
607123. gene.
neXtProtiNX_Q8NFJ6.
Orphaneti478. Kallmann syndrome.
432. Normosmic congenital hypogonadotropic hypogonadism.
3157. Septo-optic dysplasia.
PharmGKBiPA30014.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG319668.
GeneTreeiENSGT00770000120614.
HOGENOMiHOG000231664.
HOVERGENiHBG039631.
InParanoidiQ8NFJ6.
KOiK08380.
OMAiDYDLPMD.
OrthoDBiEOG73NG3D.
PhylomeDBiQ8NFJ6.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikiiProkineticin_receptor_2.
GenomeRNAii128674.
NextBioi82420.
PROiQ8NFJ6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NFJ6.
CleanExiHS_PROKR2.
GenevisibleiQ8NFJ6. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor."
    Lin D.C.-H., Bullock C.M., Ehlert F.J., Chen J.-L., Tian H., Zhou Q.-Y.
    J. Biol. Chem. 277:19276-19280(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Martin A.L., Kaighin V.A., Aronstam R.S.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-331.
    Tissue: Testis.
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Evidence that prokineticin receptor 2 exists as a dimer in vivo."
    Marsango S., Bonaccorsi di Patti M.C., Barra D., Miele R.
    Cell. Mol. Life Sci. 68:2919-2929(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  7. Cited for: VARIANTS HH3 CYS-85; HIS-85; GLN-164; ARG-173; SER-178; ARG-210; CYS-268; SER-290; ILE-323 AND MET-331, VARIANT MET-335.
  8. "Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum."
    Cole L.W., Sidis Y., Zhang C., Quinton R., Plummer L., Pignatelli D., Hughes V.A., Dwyer A.A., Raivio T., Hayes F.J., Seminara S.B., Huot C., Alos N., Speiser P., Takeshita A., Van Vliet G., Pearce S., Crowley W.F. Jr., Zhou Q.Y., Pitteloud N.
    J. Clin. Endocrinol. Metab. 93:3551-3559(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS HH3 CYS-85; HIS-113; MET-115; GLN-164; ARG-173; SER-178; LEU-188; GLN-248; MET-331 AND TRP-357, CHARACTERIZATIONV OF VARIANTS HH3 CYS-85; HIS-113; MET-115; GLN-164; ARG-173; SER-178; LEU-188; GLN-248; MET-331 AND TRP-357.
  9. "PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity."
    Monnier C., Dode C., Fabre L., Teixeira L., Labesse G., Pin J.P., Hardelin J.P., Rondard P.
    Hum. Mol. Genet. 18:75-81(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF VARIANTS HH3 CYS-85; HIS-85; GLN-164; ARG-173; SER-178; ARG-210; CYS-268; SER-290; ILE-323 AND MET-331, SUBCELLULAR LOCATION.
  10. Cited for: VARIANT HH3 CYS-268.
  11. Cited for: VARIANTS HH3 MET-115 AND GLY-202.
  12. Cited for: VARIANTS HH3 CYS-85; HIS-85; ILE-158; ARG-173; SER-290 AND MET-334.

Entry informationi

Entry nameiPKR2_HUMAN
AccessioniPrimary (citable) accession number: Q8NFJ6
Secondary accession number(s): A5JUU1
, Q2M3C0, Q5TDY1, Q9NTT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: October 1, 2002
Last modified: June 24, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.