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Q8NFI9 (Q8NFI9_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor RuleBase RU049442

Short name=FGF RuleBase RU049442
Gene names
Name:FGF10 EMBL AAM46926.1
OrganismHomo sapiens (Human) EMBL AAM46926.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length170 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the heparin-binding growth factors family. RuleBase RU049442

Ontologies

Gene Ontology (GO)
   Biological_processHarderian gland development

Inferred from electronic annotation. Source: Ensembl

Type II pneumocyte differentiation

Inferred from electronic annotation. Source: Ensembl

angiogenesis

Inferred from electronic annotation. Source: Ensembl

blood vessel remodeling

Inferred from electronic annotation. Source: Ensembl

branch elongation involved in salivary gland morphogenesis

Inferred from electronic annotation. Source: Ensembl

bronchiole morphogenesis

Inferred from electronic annotation. Source: Ensembl

determination of left/right symmetry

Inferred from electronic annotation. Source: Ensembl

embryonic camera-type eye development

Inferred from electronic annotation. Source: Ensembl

embryonic digestive tract morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic genitalia morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic pattern specification

Inferred from electronic annotation. Source: Ensembl

epithelial cell migration

Inferred from electronic annotation. Source: Ensembl

epithelial cell proliferation involved in salivary gland morphogenesis

Inferred from electronic annotation. Source: Ensembl

epithelial tube branching involved in lung morphogenesis

Inferred from electronic annotation. Source: Ensembl

female genitalia morphogenesis

Inferred from electronic annotation. Source: Ensembl

fibroblast growth factor receptor signaling pathway involved in mammary gland specification

Inferred from electronic annotation. Source: Ensembl

hair follicle morphogenesis

Inferred from electronic annotation. Source: Ensembl

induction of positive chemotaxis

Inferred from electronic annotation. Source: Ensembl

keratinocyte proliferation

Inferred from electronic annotation. Source: Ensembl

lacrimal gland development

Inferred from electronic annotation. Source: Ensembl

limb bud formation

Inferred from electronic annotation. Source: Ensembl

lung alveolus development

Inferred from electronic annotation. Source: Ensembl

lung proximal/distal axis specification

Inferred from electronic annotation. Source: Ensembl

male genitalia morphogenesis

Inferred from electronic annotation. Source: Ensembl

mammary gland bud formation

Inferred from electronic annotation. Source: Ensembl

mesenchymal cell differentiation involved in lung development

Inferred from electronic annotation. Source: Ensembl

mesenchymal-epithelial cell signaling involved in lung development

Inferred from electronic annotation. Source: Ensembl

metanephros morphogenesis

Inferred from electronic annotation. Source: Ensembl

muscle cell fate commitment

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Inferred from electronic annotation. Source: Ensembl

odontogenesis of dentin-containing tooth

Inferred from electronic annotation. Source: Ensembl

organ growth

Inferred from electronic annotation. Source: Ensembl

organ induction

Inferred from electronic annotation. Source: Ensembl

otic vesicle formation

Inferred from electronic annotation. Source: Ensembl

pancreas development

Inferred from electronic annotation. Source: Ensembl

pituitary gland development

Inferred from electronic annotation. Source: Ensembl

positive regulation of ERK1 and ERK2 cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of Notch signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of fibroblast proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of mitotic cell cycle

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of vascular endothelial growth factor receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of white fat cell proliferation

Inferred from electronic annotation. Source: Ensembl

radial glial cell differentiation

Inferred from electronic annotation. Source: Ensembl

regulation of activin receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

Inferred from electronic annotation. Source: Ensembl

regulation of prostatic bud formation

Inferred from electronic annotation. Source: Ensembl

regulation of smoothened signaling pathway

Inferred from electronic annotation. Source: Ensembl

response to estradiol

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

semicircular canal fusion

Inferred from electronic annotation. Source: Ensembl

smooth muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

somatic stem cell maintenance

Inferred from electronic annotation. Source: Ensembl

spleen development

Inferred from electronic annotation. Source: Ensembl

submandibular salivary gland formation

Inferred from electronic annotation. Source: Ensembl

thyroid gland development

Inferred from electronic annotation. Source: Ensembl

tissue regeneration

Inferred from electronic annotation. Source: Ensembl

white fat cell differentiation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionchemoattractant activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAM46926.1

Sequences

Sequence LengthMass (Da)Tools
Q8NFI9 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 4EA43515F758327A

FASTA17019,195
        10         20         30         40         50         60 
ALGQDMVSPE ATNSSSSSFS SPSSAGRHVR SYNHLQGDVR WRKLFSFTKY FLKIEKNGKV 

        70         80         90        100        110        120 
SGTKKENCPY SILEITSVEI GVVAVKAINS NYYLAMNKKG KLYGSKEFNN DCKLKERIEE 

       130        140        150        160        170 
NGYNTYASFN WQHNGRQMYV ALNGKGAPRR GQKTRRKNTS AHFLPMVVHS 

« Hide

References

[1]"Fibroblast growth factor-10 is a mitogen for urothelial cells."
Bagai S., Rubio E., Cheng J.F., Sweet R., Thomas R., Fuchs E., Grady R., Mitchell M., Bassuk J.A.
J. Biol. Chem. 277:23828-23837(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Bladder EMBL AAM46926.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF508782 mRNA. Translation: AAM46926.1.
UniGeneHs.664499.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG007580.

Gene expression databases

ArrayExpressQ8NFI9.
BgeeQ8NFI9.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR028252. FGF10.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF21. PTHR11486:SF21. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ8NFI9_HUMAN
AccessionPrimary (citable) accession number: Q8NFI9
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: March 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.