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Q8NFH5

- NUP53_HUMAN

UniProt

Q8NFH5 - NUP53_HUMAN

Protein

Nucleoporin NUP53

Gene

NUP35

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs). Can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC.1 Publication

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. cytokine-mediated signaling pathway Source: Reactome
    3. glucose transport Source: Reactome
    4. hexose transport Source: Reactome
    5. mitotic cell cycle Source: Reactome
    6. mitotic nuclear envelope disassembly Source: Reactome
    7. mRNA transport Source: UniProtKB-KW
    8. protein transport Source: UniProtKB-KW
    9. regulation of glucose transport Source: Reactome
    10. small molecule metabolic process Source: Reactome
    11. transmembrane transport Source: Reactome
    12. viral process Source: Reactome

    Keywords - Biological processi

    mRNA transport, Protein transport, Translocation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_115831. ISG15 antiviral mechanism.
    REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
    REACT_6190. Rev-mediated nuclear export of HIV RNA.
    REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
    REACT_7991. Vpr-mediated nuclear import of PICs.
    REACT_9395. Nuclear import of Rev protein.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoporin NUP53
    Alternative name(s):
    35 kDa nucleoporin
    Mitotic phosphoprotein 44
    Short name:
    MP-44
    Nuclear pore complex protein Nup53
    Nucleoporin Nup35
    Gene namesi
    Name:NUP35
    Synonyms:MP44, NUP53
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:29797. NUP35.

    Subcellular locationi

    Nucleusnuclear pore complex. Nucleus membrane; Peripheral membrane protein
    Note: Tightly associated with the nuclear membrane and lamina.

    GO - Cellular componenti

    1. intermediate filament cytoskeleton Source: HPA
    2. intracellular membrane-bounded organelle Source: HPA
    3. nuclear envelope Source: Reactome
    4. nuclear membrane Source: HPA
    5. nuclear pore Source: UniProtKB-SubCell
    6. nucleus Source: HPA
    7. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Membrane, Nuclear pore complex, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134861481.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Nucleoporin NUP53PRO_0000234294Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei66 – 661Phosphoserine1 Publication
    Modified residuei73 – 731Phosphoserine3 Publications
    Modified residuei99 – 991Phosphoserine1 Publication
    Modified residuei100 – 1001Phosphoserine3 Publications
    Modified residuei106 – 1061Phosphothreonine2 Publications
    Modified residuei121 – 1211Phosphoserine1 Publication
    Modified residuei129 – 1291Phosphothreonine1 Publication
    Modified residuei138 – 1381Phosphoserine1 Publication
    Modified residuei259 – 2591PhosphoserineBy similarity
    Modified residuei265 – 2651Phosphothreonine1 Publication
    Modified residuei273 – 2731Phosphothreonine2 Publications
    Modified residuei279 – 2791Phosphoserine2 Publications
    Modified residuei280 – 2801Phosphothreonine2 Publications
    Modified residuei308 – 3081Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8NFH5.
    PaxDbiQ8NFH5.
    PeptideAtlasiQ8NFH5.
    PRIDEiQ8NFH5.

    PTM databases

    PhosphoSiteiQ8NFH5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NFH5.
    BgeeiQ8NFH5.
    CleanExiHS_NUP35.
    GenevestigatoriQ8NFH5.

    Organism-specific databases

    HPAiHPA018401.
    HPA018410.
    HPA018441.

    Interactioni

    Subunit structurei

    Interacts with TMEM48/NDC1. Forms a complex with NUP93, NUP155, NUP205 and lamin B; the interaction with NUP93 is direct.2 Publications

    Protein-protein interaction databases

    BioGridi126190. 4 interactions.
    DIPiDIP-47308N.
    IntActiQ8NFH5. 3 interactions.
    MINTiMINT-4301788.
    STRINGi9606.ENSP00000295119.

    Structurei

    Secondary structure

    1
    326
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi172 – 1743
    Beta strandi175 – 1795
    Helixi183 – 1853
    Helixi186 – 1938
    Beta strandi199 – 2046
    Beta strandi206 – 21712
    Helixi218 – 2258
    Turni226 – 2294
    Beta strandi230 – 2323
    Turni233 – 2353
    Beta strandi236 – 2427
    Helixi246 – 2494

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4LIRX-ray2.46A/B151-266[»]
    ProteinModelPortaliQ8NFH5.
    SMRiQ8NFH5. Positions 169-252.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini170 – 25081RRM Nup35-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Nup53 family.Curated
    Contains 1 RRM Nup35-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG253574.
    HOGENOMiHOG000231921.
    HOVERGENiHBG060396.
    InParanoidiQ8NFH5.
    KOiK14313.
    OMAiANISVMQ.
    PhylomeDBiQ8NFH5.
    TreeFamiTF325369.

    Family and domain databases

    InterProiIPR017389. Nucleoporin_NUP53.
    IPR007846. RRM_NUP35_dom.
    [Graphical view]
    PfamiPF05172. Nup35_RRM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038119. Nucleoporin_NUP53. 1 hit.
    PROSITEiPS51472. RRM_NUP35. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NFH5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAFAVEPQG PALGSEPMML GSPTSPKPGV NAQFLPGFLM GDLPAPVTPQ    50
    PRSISGPSVG VMEMRSPLLA GGSPPQPVVP AHKDKSGAPP VRSIYDDISS 100
    PGLGSTPLTS RRQPNISVMQ SPLVGVTSTP GTGQSMFSPA SIGQPRKTTL 150
    SPAQLDPFYT QGDSLTSEDH LDDSWVTVFG FPQASASYIL LQFAQYGNIL 200
    KHVMSNTGNW MHIRYQSKLQ ARKALSKDGR IFGESIMIGV KPCIDKSVME 250
    SSDRCALSSP SLAFTPPIKT LGTPTQPGST PRISTMRPLA TAYKASTSDY 300
    QVISDRQTPK KDESLVSKAM EYMFGW 326
    Length:326
    Mass (Da):34,774
    Last modified:October 1, 2002 - v1
    Checksum:i6420B0EF1AE31013
    GO
    Isoform 2 (identifier: Q8NFH5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-17: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:309
    Mass (Da):33,120
    Checksum:iBA43C9E8B0BD3BD1
    GO
    Isoform 3 (identifier: Q8NFH5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-135: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:191
    Mass (Da):21,142
    Checksum:i96265A68DC195F33
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti313 – 3131E → G in AAL86379. 1 PublicationCurated
    Sequence conflicti318 – 3181K → Q in AAL86379. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 135135Missing in isoform 3. 1 PublicationVSP_056210Add
    BLAST
    Alternative sequencei1 – 1717Missing in isoform 2. 1 PublicationVSP_056211Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF514993 mRNA. Translation: AAM76704.1.
    AF411516 mRNA. Translation: AAL86379.1.
    AK298199 mRNA. Translation: BAG60469.1.
    AK302350 mRNA. Translation: BAG63676.1.
    AC064871 Genomic DNA. Translation: AAY24198.1.
    AC079249 Genomic DNA. Translation: AAX88896.1.
    BC047029 mRNA. Translation: AAH47029.1.
    BC061698 mRNA. Translation: AAH61698.1.
    CCDSiCCDS2290.1.
    RefSeqiNP_001274513.1. NM_001287584.1.
    NP_001274514.1. NM_001287585.1.
    NP_612142.2. NM_138285.4.
    UniGeneiHs.180591.

    Genome annotation databases

    EnsembliENST00000295119; ENSP00000295119; ENSG00000163002.
    ENST00000409798; ENSP00000387305; ENSG00000163002.
    ENST00000541912; ENSP00000442019; ENSG00000163002.
    GeneIDi129401.
    KEGGihsa:129401.
    UCSCiuc002upf.3. human.

    Polymorphism databases

    DMDMi74730292.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF514993 mRNA. Translation: AAM76704.1 .
    AF411516 mRNA. Translation: AAL86379.1 .
    AK298199 mRNA. Translation: BAG60469.1 .
    AK302350 mRNA. Translation: BAG63676.1 .
    AC064871 Genomic DNA. Translation: AAY24198.1 .
    AC079249 Genomic DNA. Translation: AAX88896.1 .
    BC047029 mRNA. Translation: AAH47029.1 .
    BC061698 mRNA. Translation: AAH61698.1 .
    CCDSi CCDS2290.1.
    RefSeqi NP_001274513.1. NM_001287584.1.
    NP_001274514.1. NM_001287585.1.
    NP_612142.2. NM_138285.4.
    UniGenei Hs.180591.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4LIR X-ray 2.46 A/B 151-266 [» ]
    ProteinModelPortali Q8NFH5.
    SMRi Q8NFH5. Positions 169-252.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126190. 4 interactions.
    DIPi DIP-47308N.
    IntActi Q8NFH5. 3 interactions.
    MINTi MINT-4301788.
    STRINGi 9606.ENSP00000295119.

    PTM databases

    PhosphoSitei Q8NFH5.

    Polymorphism databases

    DMDMi 74730292.

    Proteomic databases

    MaxQBi Q8NFH5.
    PaxDbi Q8NFH5.
    PeptideAtlasi Q8NFH5.
    PRIDEi Q8NFH5.

    Protocols and materials databases

    DNASUi 129401.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295119 ; ENSP00000295119 ; ENSG00000163002 .
    ENST00000409798 ; ENSP00000387305 ; ENSG00000163002 .
    ENST00000541912 ; ENSP00000442019 ; ENSG00000163002 .
    GeneIDi 129401.
    KEGGi hsa:129401.
    UCSCi uc002upf.3. human.

    Organism-specific databases

    CTDi 129401.
    GeneCardsi GC02P183982.
    HGNCi HGNC:29797. NUP35.
    HPAi HPA018401.
    HPA018410.
    HPA018441.
    MIMi 608140. gene.
    neXtProti NX_Q8NFH5.
    PharmGKBi PA134861481.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253574.
    HOGENOMi HOG000231921.
    HOVERGENi HBG060396.
    InParanoidi Q8NFH5.
    KOi K14313.
    OMAi ANISVMQ.
    PhylomeDBi Q8NFH5.
    TreeFami TF325369.

    Enzyme and pathway databases

    Reactomei REACT_115831. ISG15 antiviral mechanism.
    REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
    REACT_6190. Rev-mediated nuclear export of HIV RNA.
    REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
    REACT_7991. Vpr-mediated nuclear import of PICs.
    REACT_9395. Nuclear import of Rev protein.

    Miscellaneous databases

    GeneWikii NUP35.
    GenomeRNAii 129401.
    NextBioi 82574.
    PROi Q8NFH5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NFH5.
    Bgeei Q8NFH5.
    CleanExi HS_NUP35.
    Genevestigatori Q8NFH5.

    Family and domain databases

    InterProi IPR017389. Nucleoporin_NUP53.
    IPR007846. RRM_NUP35_dom.
    [Graphical view ]
    Pfami PF05172. Nup35_RRM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038119. Nucleoporin_NUP53. 1 hit.
    PROSITEi PS51472. RRM_NUP35. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Proteomic analysis of the mammalian nuclear pore complex."
      Cronshaw J.M., Krutchinsky A.N., Zhang W., Chait B.T., Matunis M.J.
      J. Cell Biol. 158:915-927(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
    2. "Molecular cloning and expression analysis of human mitotic phosphoprotein 44 gene."
      Guo J.H., Yu L.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Testis.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Bone marrow and Skin.
    6. "Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex."
      Hawryluk-Gara L.A., Shibuya E.K., Wozniak R.W.
      Mol. Biol. Cell 16:2382-2394(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH NUP93, IDENTIFICATION IN A COMPLEX WITH LAMIN B; NUP155 AND NUP205.
    7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells."
      Mansfeld J., Guettinger S., Hawryluk-Gara L.A., Pante N., Mall M., Galy V., Haselmann U., Muehlhaeusser P., Wozniak R.W., Mattaj I.W., Kutay U., Antonin W.
      Mol. Cell 22:93-103(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TMEM48.
    9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99; SER-100; THR-106; THR-129; SER-138; THR-265; THR-273; SER-279; THR-280 AND THR-308, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-100, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66; SER-73; SER-100; THR-106; SER-121; THR-273; SER-279 AND THR-280, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNUP53_HUMAN
    AccessioniPrimary (citable) accession number: Q8NFH5
    Secondary accession number(s): B4DP57
    , B4DYB4, Q4ZFZ9, Q53S95, Q8TDJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3