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Q8NFH4

- NUP37_HUMAN

UniProt

Q8NFH4 - NUP37_HUMAN

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Protein

Nucleoporin Nup37

Gene
NUP37
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. chromosome segregation Source: UniProtKB-KW
  3. cytokine-mediated signaling pathway Source: Reactome
  4. glucose transport Source: Reactome
  5. hexose transport Source: Reactome
  6. mitotic cell cycle Source: Reactome
  7. mitotic nuclear division Source: UniProtKB-KW
  8. mitotic nuclear envelope disassembly Source: Reactome
  9. mRNA transport Source: UniProtKB-KW
  10. protein transport Source: UniProtKB-KW
  11. regulation of glucose transport Source: Reactome
  12. small molecule metabolic process Source: Reactome
  13. transmembrane transport Source: Reactome
  14. viral process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, Mitosis, mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_115831. ISG15 antiviral mechanism.
REACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
REACT_6190. Rev-mediated nuclear export of HIV RNA.
REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_682. Mitotic Prometaphase.
REACT_7991. Vpr-mediated nuclear import of PICs.
REACT_9395. Nuclear import of Rev protein.
SignaLinkiQ8NFH4.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin Nup37
Short name:
p37
Alternative name(s):
Nup107-160 subcomplex subunit Nup37
Gene namesi
Name:NUP37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:29929. NUP37.

Subcellular locationi

Chromosomecentromerekinetochore. Nucleusnuclear pore complex 2 Publications

GO - Cellular componenti

  1. condensed chromosome kinetochore Source: UniProtKB-SubCell
  2. cytosol Source: Reactome
  3. nuclear envelope Source: Reactome
  4. nuclear pore outer ring Source: UniProtKB
  5. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134948997.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Nucleoporin Nup37PRO_0000051109Add
BLAST

Proteomic databases

MaxQBiQ8NFH4.
PaxDbiQ8NFH4.
PeptideAtlasiQ8NFH4.
PRIDEiQ8NFH4.

PTM databases

PhosphoSiteiQ8NFH4.

Expressioni

Gene expression databases

ArrayExpressiQ8NFH4.
BgeeiQ8NFH4.
CleanExiHS_NUP37.
GenevestigatoriQ8NFH4.

Organism-specific databases

HPAiHPA056300.

Interactioni

Subunit structurei

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13.2 Publications

Protein-protein interaction databases

BioGridi122491. 12 interactions.
IntActiQ8NFH4. 5 interactions.
MINTiMINT-4786758.
STRINGi9606.ENSP00000251074.

Structurei

3D structure databases

ProteinModelPortaliQ8NFH4.
SMRiQ8NFH4. Positions 34-243.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati70 – 11748WD 1Add
BLAST
Repeati122 – 16241WD 2Add
BLAST
Repeati164 – 20340WD 3Add
BLAST
Repeati294 – 32532WD 4Add
BLAST

Sequence similaritiesi

Contains 4 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG243810.
HOGENOMiHOG000007266.
HOVERGENiHBG052695.
InParanoidiQ8NFH4.
KOiK14302.
OMAiMCTFQEE.
OrthoDBiEOG73RBBW.
PhylomeDBiQ8NFH4.
TreeFamiTF325769.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NFH4-1 [UniParc]FASTAAdd to Basket

« Hide

MKQDASRNAA YTVDCEDYVH VVEFNPFENG DSGNLIAYGG NNYVVIGTCT    50
FQEEEADVEG IQYKTLRTFH HGVRVDGIAW SPETRLDSLP PVIKFCTSAA 100
DMKIRLFTSD LQDKNEYKVL EGHTDFINGL VFDPKEGQEI ASVSDDHTCR 150
IWNLEGVQTA HFVLHSPGMS VCWHPEETFK LMVAEKNGTI RFYDLLAQQA 200
ILSLESEQVP LMSAHWCLKN TFKVGAVAGN DWLIWDITRS SYPQNKRPVH 250
MDRACLFRWS TISENLFATT GYPGKMASQF QIHHLGHPQP ILMGSVAVGS 300
GLSWHRTLPL CVIGGDHKLL FWVTEV 326
Length:326
Mass (Da):36,708
Last modified:October 1, 2002 - v1
Checksum:i188E6D9D0CDF2DD7
GO

Sequence cautioni

The sequence BAB15422.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF514994 mRNA. Translation: AAM76705.1.
BC000861 mRNA. Translation: AAH00861.2.
AK026271 mRNA. Translation: BAB15422.1. Different initiation.
CCDSiCCDS9089.1.
RefSeqiNP_076962.2. NM_024057.2.
XP_005269201.1. XM_005269144.1.
UniGeneiHs.444276.

Genome annotation databases

EnsembliENST00000251074; ENSP00000251074; ENSG00000075188.
ENST00000552283; ENSP00000448054; ENSG00000075188.
GeneIDi79023.
KEGGihsa:79023.
UCSCiuc001tjc.3. human.

Polymorphism databases

DMDMi27923820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF514994 mRNA. Translation: AAM76705.1 .
BC000861 mRNA. Translation: AAH00861.2 .
AK026271 mRNA. Translation: BAB15422.1 . Different initiation.
CCDSi CCDS9089.1.
RefSeqi NP_076962.2. NM_024057.2.
XP_005269201.1. XM_005269144.1.
UniGenei Hs.444276.

3D structure databases

ProteinModelPortali Q8NFH4.
SMRi Q8NFH4. Positions 34-243.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122491. 12 interactions.
IntActi Q8NFH4. 5 interactions.
MINTi MINT-4786758.
STRINGi 9606.ENSP00000251074.

PTM databases

PhosphoSitei Q8NFH4.

Polymorphism databases

DMDMi 27923820.

Proteomic databases

MaxQBi Q8NFH4.
PaxDbi Q8NFH4.
PeptideAtlasi Q8NFH4.
PRIDEi Q8NFH4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000251074 ; ENSP00000251074 ; ENSG00000075188 .
ENST00000552283 ; ENSP00000448054 ; ENSG00000075188 .
GeneIDi 79023.
KEGGi hsa:79023.
UCSCi uc001tjc.3. human.

Organism-specific databases

CTDi 79023.
GeneCardsi GC12M102467.
HGNCi HGNC:29929. NUP37.
HPAi HPA056300.
MIMi 609264. gene.
neXtProti NX_Q8NFH4.
PharmGKBi PA134948997.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG243810.
HOGENOMi HOG000007266.
HOVERGENi HBG052695.
InParanoidi Q8NFH4.
KOi K14302.
OMAi MCTFQEE.
OrthoDBi EOG73RBBW.
PhylomeDBi Q8NFH4.
TreeFami TF325769.

Enzyme and pathway databases

Reactomei REACT_115831. ISG15 antiviral mechanism.
REACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
REACT_6190. Rev-mediated nuclear export of HIV RNA.
REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_682. Mitotic Prometaphase.
REACT_7991. Vpr-mediated nuclear import of PICs.
REACT_9395. Nuclear import of Rev protein.
SignaLinki Q8NFH4.

Miscellaneous databases

GenomeRNAii 79023.
NextBioi 67702.
PROi Q8NFH4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8NFH4.
Bgeei Q8NFH4.
CleanExi HS_NUP37.
Genevestigatori Q8NFH4.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM00320. WD40. 3 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Proteomic analysis of the mammalian nuclear pore complex."
    Cronshaw J.M., Krutchinsky A.N., Zhang W., Chait B.T., Matunis M.J.
    J. Cell Biol. 158:915-927(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-326.
    Tissue: Small intestine.
  4. "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis."
    Loieodice I., Alves A., Rabut G., Van Overbeek M., Ellenberg J., Sibarita J.-B., Doye V.
    Mol. Biol. Cell 15:3333-3344(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NUP107-160 COMPLEX, SUBCELLULAR LOCATION.
  5. "The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions."
    Zuccolo M., Alves A., Galy V., Bolhy S., Formstecher E., Racine V., Sibarita J.-B., Fukagawa T., Shiekhattar R., Yen T., Doye V.
    EMBO J. 26:1853-1864(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE NUP107-160 COMPLEX.
  6. "Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex."
    Glavy J.S., Krutchinsky A.N., Cristea I.M., Berke I.C., Boehmer T., Blobel G., Chait B.T.
    Proc. Natl. Acad. Sci. U.S.A. 104:3811-3816(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE NUP107-160 COMPLEX.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNUP37_HUMAN
AccessioniPrimary (citable) accession number: Q8NFH4
Secondary accession number(s): Q9H644
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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