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Q8NFH4

- NUP37_HUMAN

UniProt

Q8NFH4 - NUP37_HUMAN

Protein

Nucleoporin Nup37

Gene

NUP37

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. chromosome segregation Source: UniProtKB-KW
    3. cytokine-mediated signaling pathway Source: Reactome
    4. glucose transport Source: Reactome
    5. hexose transport Source: Reactome
    6. mitotic cell cycle Source: Reactome
    7. mitotic nuclear division Source: UniProtKB-KW
    8. mitotic nuclear envelope disassembly Source: Reactome
    9. mRNA transport Source: UniProtKB-KW
    10. protein transport Source: UniProtKB-KW
    11. regulation of glucose transport Source: Reactome
    12. small molecule metabolic process Source: Reactome
    13. transmembrane transport Source: Reactome
    14. viral process Source: Reactome

    Keywords - Biological processi

    Cell cycle, Cell division, Chromosome partition, Mitosis, mRNA transport, Protein transport, Translocation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_115831. ISG15 antiviral mechanism.
    REACT_150425. Resolution of Sister Chromatid Cohesion.
    REACT_150471. Separation of Sister Chromatids.
    REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
    REACT_6190. Rev-mediated nuclear export of HIV RNA.
    REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
    REACT_682. Mitotic Prometaphase.
    REACT_7991. Vpr-mediated nuclear import of PICs.
    REACT_9395. Nuclear import of Rev protein.
    SignaLinkiQ8NFH4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoporin Nup37
    Short name:
    p37
    Alternative name(s):
    Nup107-160 subcomplex subunit Nup37
    Gene namesi
    Name:NUP37
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:29929. NUP37.

    Subcellular locationi

    GO - Cellular componenti

    1. condensed chromosome kinetochore Source: UniProtKB-SubCell
    2. cytosol Source: Reactome
    3. nuclear envelope Source: Reactome
    4. nuclear pore outer ring Source: UniProtKB
    5. nucleus Source: UniProt

    Keywords - Cellular componenti

    Centromere, Chromosome, Kinetochore, Nuclear pore complex, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134948997.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Nucleoporin Nup37PRO_0000051109Add
    BLAST

    Proteomic databases

    MaxQBiQ8NFH4.
    PaxDbiQ8NFH4.
    PeptideAtlasiQ8NFH4.
    PRIDEiQ8NFH4.

    PTM databases

    PhosphoSiteiQ8NFH4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NFH4.
    BgeeiQ8NFH4.
    CleanExiHS_NUP37.
    GenevestigatoriQ8NFH4.

    Organism-specific databases

    HPAiHPA056300.

    Interactioni

    Subunit structurei

    Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13.2 Publications

    Protein-protein interaction databases

    BioGridi122491. 12 interactions.
    IntActiQ8NFH4. 5 interactions.
    MINTiMINT-4786758.
    STRINGi9606.ENSP00000251074.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NFH4.
    SMRiQ8NFH4. Positions 34-243.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati70 – 11748WD 1Add
    BLAST
    Repeati122 – 16241WD 2Add
    BLAST
    Repeati164 – 20340WD 3Add
    BLAST
    Repeati294 – 32532WD 4Add
    BLAST

    Sequence similaritiesi

    Contains 4 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG243810.
    HOGENOMiHOG000007266.
    HOVERGENiHBG052695.
    InParanoidiQ8NFH4.
    KOiK14302.
    OMAiMCTFQEE.
    OrthoDBiEOG73RBBW.
    PhylomeDBiQ8NFH4.
    TreeFamiTF325769.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 1 hit.
    [Graphical view]
    SMARTiSM00320. WD40. 3 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NFH4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKQDASRNAA YTVDCEDYVH VVEFNPFENG DSGNLIAYGG NNYVVIGTCT    50
    FQEEEADVEG IQYKTLRTFH HGVRVDGIAW SPETRLDSLP PVIKFCTSAA 100
    DMKIRLFTSD LQDKNEYKVL EGHTDFINGL VFDPKEGQEI ASVSDDHTCR 150
    IWNLEGVQTA HFVLHSPGMS VCWHPEETFK LMVAEKNGTI RFYDLLAQQA 200
    ILSLESEQVP LMSAHWCLKN TFKVGAVAGN DWLIWDITRS SYPQNKRPVH 250
    MDRACLFRWS TISENLFATT GYPGKMASQF QIHHLGHPQP ILMGSVAVGS 300
    GLSWHRTLPL CVIGGDHKLL FWVTEV 326
    Length:326
    Mass (Da):36,708
    Last modified:October 1, 2002 - v1
    Checksum:i188E6D9D0CDF2DD7
    GO

    Sequence cautioni

    The sequence BAB15422.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF514994 mRNA. Translation: AAM76705.1.
    BC000861 mRNA. Translation: AAH00861.2.
    AK026271 mRNA. Translation: BAB15422.1. Different initiation.
    CCDSiCCDS9089.1.
    RefSeqiNP_076962.2. NM_024057.2.
    XP_005269201.1. XM_005269144.1.
    UniGeneiHs.444276.

    Genome annotation databases

    EnsembliENST00000251074; ENSP00000251074; ENSG00000075188.
    ENST00000552283; ENSP00000448054; ENSG00000075188.
    GeneIDi79023.
    KEGGihsa:79023.
    UCSCiuc001tjc.3. human.

    Polymorphism databases

    DMDMi27923820.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF514994 mRNA. Translation: AAM76705.1 .
    BC000861 mRNA. Translation: AAH00861.2 .
    AK026271 mRNA. Translation: BAB15422.1 . Different initiation.
    CCDSi CCDS9089.1.
    RefSeqi NP_076962.2. NM_024057.2.
    XP_005269201.1. XM_005269144.1.
    UniGenei Hs.444276.

    3D structure databases

    ProteinModelPortali Q8NFH4.
    SMRi Q8NFH4. Positions 34-243.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122491. 12 interactions.
    IntActi Q8NFH4. 5 interactions.
    MINTi MINT-4786758.
    STRINGi 9606.ENSP00000251074.

    PTM databases

    PhosphoSitei Q8NFH4.

    Polymorphism databases

    DMDMi 27923820.

    Proteomic databases

    MaxQBi Q8NFH4.
    PaxDbi Q8NFH4.
    PeptideAtlasi Q8NFH4.
    PRIDEi Q8NFH4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000251074 ; ENSP00000251074 ; ENSG00000075188 .
    ENST00000552283 ; ENSP00000448054 ; ENSG00000075188 .
    GeneIDi 79023.
    KEGGi hsa:79023.
    UCSCi uc001tjc.3. human.

    Organism-specific databases

    CTDi 79023.
    GeneCardsi GC12M102467.
    HGNCi HGNC:29929. NUP37.
    HPAi HPA056300.
    MIMi 609264. gene.
    neXtProti NX_Q8NFH4.
    PharmGKBi PA134948997.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG243810.
    HOGENOMi HOG000007266.
    HOVERGENi HBG052695.
    InParanoidi Q8NFH4.
    KOi K14302.
    OMAi MCTFQEE.
    OrthoDBi EOG73RBBW.
    PhylomeDBi Q8NFH4.
    TreeFami TF325769.

    Enzyme and pathway databases

    Reactomei REACT_115831. ISG15 antiviral mechanism.
    REACT_150425. Resolution of Sister Chromatid Cohesion.
    REACT_150471. Separation of Sister Chromatids.
    REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
    REACT_6190. Rev-mediated nuclear export of HIV RNA.
    REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
    REACT_682. Mitotic Prometaphase.
    REACT_7991. Vpr-mediated nuclear import of PICs.
    REACT_9395. Nuclear import of Rev protein.
    SignaLinki Q8NFH4.

    Miscellaneous databases

    GenomeRNAii 79023.
    NextBioi 67702.
    PROi Q8NFH4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NFH4.
    Bgeei Q8NFH4.
    CleanExi HS_NUP37.
    Genevestigatori Q8NFH4.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 1 hit.
    [Graphical view ]
    SMARTi SM00320. WD40. 3 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Proteomic analysis of the mammalian nuclear pore complex."
      Cronshaw J.M., Krutchinsky A.N., Zhang W., Chait B.T., Matunis M.J.
      J. Cell Biol. 158:915-927(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cervix.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-326.
      Tissue: Small intestine.
    4. "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis."
      Loieodice I., Alves A., Rabut G., Van Overbeek M., Ellenberg J., Sibarita J.-B., Doye V.
      Mol. Biol. Cell 15:3333-3344(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE NUP107-160 COMPLEX, SUBCELLULAR LOCATION.
    5. "The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions."
      Zuccolo M., Alves A., Galy V., Bolhy S., Formstecher E., Racine V., Sibarita J.-B., Fukagawa T., Shiekhattar R., Yen T., Doye V.
      EMBO J. 26:1853-1864(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE NUP107-160 COMPLEX.
    6. "Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex."
      Glavy J.S., Krutchinsky A.N., Cristea I.M., Berke I.C., Boehmer T., Blobel G., Chait B.T.
      Proc. Natl. Acad. Sci. U.S.A. 104:3811-3816(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE NUP107-160 COMPLEX.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNUP37_HUMAN
    AccessioniPrimary (citable) accession number: Q8NFH4
    Secondary accession number(s): Q9H644
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 27, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3