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Protein

Nucleoporin Nup37

Gene

NUP37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, Mitosis, mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_115831. ISG15 antiviral mechanism.
REACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
REACT_264487. Regulation of HSF1-mediated heat shock response.
REACT_268530. Transcriptional regulation by small RNAs.
REACT_355174. SUMOylation of DNA damage response and repair proteins.
REACT_355252. RHO GTPases Activate Formins.
REACT_6190. Rev-mediated nuclear export of HIV RNA.
REACT_6354. Viral Messenger RNA Synthesis.
REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_682. Mitotic Prometaphase.
REACT_7991. Vpr-mediated nuclear import of PICs.
REACT_9395. Nuclear import of Rev protein.
SignaLinkiQ8NFH4.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin Nup37
Short name:
p37
Alternative name(s):
Nup107-160 subcomplex subunit Nup37
Gene namesi
Name:NUP37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:29929. NUP37.

Subcellular locationi

GO - Cellular componenti

  • condensed chromosome kinetochore Source: UniProtKB-SubCell
  • cytosol Source: Reactome
  • nuclear envelope Source: Reactome
  • nuclear pore outer ring Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134948997.

Polymorphism and mutation databases

BioMutaiNUP37.
DMDMi27923820.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Nucleoporin Nup37PRO_0000051109Add
BLAST

Proteomic databases

MaxQBiQ8NFH4.
PaxDbiQ8NFH4.
PeptideAtlasiQ8NFH4.
PRIDEiQ8NFH4.

PTM databases

PhosphoSiteiQ8NFH4.

Expressioni

Gene expression databases

BgeeiQ8NFH4.
CleanExiHS_NUP37.
ExpressionAtlasiQ8NFH4. baseline and differential.
GenevisibleiQ8NFH4. HS.

Interactioni

Subunit structurei

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13.2 Publications

Protein-protein interaction databases

BioGridi122491. 12 interactions.
IntActiQ8NFH4. 5 interactions.
MINTiMINT-4786758.
STRINGi9606.ENSP00000251074.

Structurei

3D structure databases

ProteinModelPortaliQ8NFH4.
SMRiQ8NFH4. Positions 34-243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati6 – 5449WD 1Add
BLAST
Repeati61 – 10949WD 2Add
BLAST
Repeati115 – 15440WD 3Add
BLAST
Repeati159 – 19537WD 4Add
BLAST
Repeati199 – 23739WD 5Add
BLAST
Repeati242 – 28241WD 6Add
BLAST
Repeati287 – 32438WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG243810.
GeneTreeiENSGT00390000010777.
HOGENOMiHOG000007266.
HOVERGENiHBG052695.
InParanoidiQ8NFH4.
KOiK14302.
OMAiFPLMSAD.
OrthoDBiEOG73RBBW.
PhylomeDBiQ8NFH4.
TreeFamiTF325769.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NFH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQDASRNAA YTVDCEDYVH VVEFNPFENG DSGNLIAYGG NNYVVIGTCT
60 70 80 90 100
FQEEEADVEG IQYKTLRTFH HGVRVDGIAW SPETRLDSLP PVIKFCTSAA
110 120 130 140 150
DMKIRLFTSD LQDKNEYKVL EGHTDFINGL VFDPKEGQEI ASVSDDHTCR
160 170 180 190 200
IWNLEGVQTA HFVLHSPGMS VCWHPEETFK LMVAEKNGTI RFYDLLAQQA
210 220 230 240 250
ILSLESEQVP LMSAHWCLKN TFKVGAVAGN DWLIWDITRS SYPQNKRPVH
260 270 280 290 300
MDRACLFRWS TISENLFATT GYPGKMASQF QIHHLGHPQP ILMGSVAVGS
310 320
GLSWHRTLPL CVIGGDHKLL FWVTEV
Length:326
Mass (Da):36,708
Last modified:October 1, 2002 - v1
Checksum:i188E6D9D0CDF2DD7
GO

Sequence cautioni

The sequence BAB15422.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF514994 mRNA. Translation: AAM76705.1.
BC000861 mRNA. Translation: AAH00861.2.
AK026271 mRNA. Translation: BAB15422.1. Different initiation.
CCDSiCCDS9089.1.
RefSeqiNP_076962.2. NM_024057.2.
XP_005269201.1. XM_005269144.2.
UniGeneiHs.444276.

Genome annotation databases

EnsembliENST00000251074; ENSP00000251074; ENSG00000075188.
ENST00000552283; ENSP00000448054; ENSG00000075188.
GeneIDi79023.
KEGGihsa:79023.
UCSCiuc001tjc.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF514994 mRNA. Translation: AAM76705.1.
BC000861 mRNA. Translation: AAH00861.2.
AK026271 mRNA. Translation: BAB15422.1. Different initiation.
CCDSiCCDS9089.1.
RefSeqiNP_076962.2. NM_024057.2.
XP_005269201.1. XM_005269144.2.
UniGeneiHs.444276.

3D structure databases

ProteinModelPortaliQ8NFH4.
SMRiQ8NFH4. Positions 34-243.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122491. 12 interactions.
IntActiQ8NFH4. 5 interactions.
MINTiMINT-4786758.
STRINGi9606.ENSP00000251074.

PTM databases

PhosphoSiteiQ8NFH4.

Polymorphism and mutation databases

BioMutaiNUP37.
DMDMi27923820.

Proteomic databases

MaxQBiQ8NFH4.
PaxDbiQ8NFH4.
PeptideAtlasiQ8NFH4.
PRIDEiQ8NFH4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251074; ENSP00000251074; ENSG00000075188.
ENST00000552283; ENSP00000448054; ENSG00000075188.
GeneIDi79023.
KEGGihsa:79023.
UCSCiuc001tjc.3. human.

Organism-specific databases

CTDi79023.
GeneCardsiGC12M102467.
HGNCiHGNC:29929. NUP37.
MIMi609264. gene.
neXtProtiNX_Q8NFH4.
PharmGKBiPA134948997.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG243810.
GeneTreeiENSGT00390000010777.
HOGENOMiHOG000007266.
HOVERGENiHBG052695.
InParanoidiQ8NFH4.
KOiK14302.
OMAiFPLMSAD.
OrthoDBiEOG73RBBW.
PhylomeDBiQ8NFH4.
TreeFamiTF325769.

Enzyme and pathway databases

ReactomeiREACT_115831. ISG15 antiviral mechanism.
REACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
REACT_264487. Regulation of HSF1-mediated heat shock response.
REACT_268530. Transcriptional regulation by small RNAs.
REACT_355174. SUMOylation of DNA damage response and repair proteins.
REACT_355252. RHO GTPases Activate Formins.
REACT_6190. Rev-mediated nuclear export of HIV RNA.
REACT_6354. Viral Messenger RNA Synthesis.
REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_682. Mitotic Prometaphase.
REACT_7991. Vpr-mediated nuclear import of PICs.
REACT_9395. Nuclear import of Rev protein.
SignaLinkiQ8NFH4.

Miscellaneous databases

GenomeRNAii79023.
NextBioi67702.
PROiQ8NFH4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NFH4.
CleanExiHS_NUP37.
ExpressionAtlasiQ8NFH4. baseline and differential.
GenevisibleiQ8NFH4. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Proteomic analysis of the mammalian nuclear pore complex."
    Cronshaw J.M., Krutchinsky A.N., Zhang W., Chait B.T., Matunis M.J.
    J. Cell Biol. 158:915-927(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-326.
    Tissue: Small intestine.
  4. "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis."
    Loieodice I., Alves A., Rabut G., Van Overbeek M., Ellenberg J., Sibarita J.-B., Doye V.
    Mol. Biol. Cell 15:3333-3344(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NUP107-160 COMPLEX, SUBCELLULAR LOCATION.
  5. "The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions."
    Zuccolo M., Alves A., Galy V., Bolhy S., Formstecher E., Racine V., Sibarita J.-B., Fukagawa T., Shiekhattar R., Yen T., Doye V.
    EMBO J. 26:1853-1864(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE NUP107-160 COMPLEX.
  6. "Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex."
    Glavy J.S., Krutchinsky A.N., Cristea I.M., Berke I.C., Boehmer T., Blobel G., Chait B.T.
    Proc. Natl. Acad. Sci. U.S.A. 104:3811-3816(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE NUP107-160 COMPLEX.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNUP37_HUMAN
AccessioniPrimary (citable) accession number: Q8NFH4
Secondary accession number(s): Q9H644
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: October 1, 2002
Last modified: July 22, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.