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Protein

Nucleoporin Nup37

Gene

NUP37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.1 Publication

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, Mitosis, mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-68877 Mitotic Prometaphase
SignaLinkiQ8NFH4

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin Nup37
Short name:
p37
Alternative name(s):
Nup107-160 subcomplex subunit Nup37
Gene namesi
Name:NUP37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000075188.8
HGNCiHGNC:29929 NUP37
MIMi609264 gene
neXtProtiNX_Q8NFH4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79023
OpenTargetsiENSG00000075188
PharmGKBiPA134948997

Polymorphism and mutation databases

BioMutaiNUP37
DMDMi27923820

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511091 – 326Nucleoporin Nup37Add BLAST326

Proteomic databases

EPDiQ8NFH4
MaxQBiQ8NFH4
PaxDbiQ8NFH4
PeptideAtlasiQ8NFH4
PRIDEiQ8NFH4
ProteomicsDBi73306

PTM databases

iPTMnetiQ8NFH4
PhosphoSitePlusiQ8NFH4

Expressioni

Gene expression databases

BgeeiENSG00000075188
CleanExiHS_NUP37
ExpressionAtlasiQ8NFH4 baseline and differential
GenevisibleiQ8NFH4 HS

Organism-specific databases

HPAiHPA056300
HPA073708

Interactioni

Subunit structurei

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13.2 Publications

Protein-protein interaction databases

BioGridi122491, 24 interactors
CORUMiQ8NFH4
IntActiQ8NFH4, 18 interactors
MINTiQ8NFH4
STRINGi9606.ENSP00000251074

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5A9Qelectron microscopy23.002/K/T/b1-326[»]
ProteinModelPortaliQ8NFH4
SMRiQ8NFH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 54WD 1Add BLAST49
Repeati61 – 109WD 2Add BLAST49
Repeati115 – 154WD 3Add BLAST40
Repeati159 – 195WD 4Add BLAST37
Repeati199 – 237WD 5Add BLAST39
Repeati242 – 282WD 6Add BLAST41
Repeati287 – 324WD 7Add BLAST38

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQ10 Eukaryota
ENOG410XSZQ LUCA
GeneTreeiENSGT00390000010777
HOGENOMiHOG000007266
HOVERGENiHBG052695
InParanoidiQ8NFH4
KOiK14302
OMAiCWHPEEA
OrthoDBiEOG091G0NYD
PhylomeDBiQ8NFH4
TreeFamiTF325769

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR037626 NUP37
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR22806 PTHR22806, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NFH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQDASRNAA YTVDCEDYVH VVEFNPFENG DSGNLIAYGG NNYVVIGTCT
60 70 80 90 100
FQEEEADVEG IQYKTLRTFH HGVRVDGIAW SPETRLDSLP PVIKFCTSAA
110 120 130 140 150
DMKIRLFTSD LQDKNEYKVL EGHTDFINGL VFDPKEGQEI ASVSDDHTCR
160 170 180 190 200
IWNLEGVQTA HFVLHSPGMS VCWHPEETFK LMVAEKNGTI RFYDLLAQQA
210 220 230 240 250
ILSLESEQVP LMSAHWCLKN TFKVGAVAGN DWLIWDITRS SYPQNKRPVH
260 270 280 290 300
MDRACLFRWS TISENLFATT GYPGKMASQF QIHHLGHPQP ILMGSVAVGS
310 320
GLSWHRTLPL CVIGGDHKLL FWVTEV
Length:326
Mass (Da):36,708
Last modified:October 1, 2002 - v1
Checksum:i188E6D9D0CDF2DD7
GO

Sequence cautioni

The sequence BAB15422 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF514994 mRNA Translation: AAM76705.1
BC000861 mRNA Translation: AAH00861.2
AK026271 mRNA Translation: BAB15422.1 Different initiation.
CCDSiCCDS9089.1
RefSeqiNP_076962.2, NM_024057.3
UniGeneiHs.444276

Genome annotation databases

EnsembliENST00000251074; ENSP00000251074; ENSG00000075188
ENST00000552283; ENSP00000448054; ENSG00000075188
GeneIDi79023
KEGGihsa:79023
UCSCiuc001tjc.4 human

Similar proteinsi

Entry informationi

Entry nameiNUP37_HUMAN
AccessioniPrimary (citable) accession number: Q8NFH4
Secondary accession number(s): Q9H644
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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