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Q8NFH3

- NUP43_HUMAN

UniProt

Q8NFH3 - NUP43_HUMAN

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Protein

Nucleoporin Nup43

Gene
NUP43
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. chromosome segregation Source: UniProtKB-KW
  3. cytokine-mediated signaling pathway Source: Reactome
  4. glucose transport Source: Reactome
  5. hexose transport Source: Reactome
  6. mitotic cell cycle Source: Reactome
  7. mitotic nuclear division Source: UniProtKB-KW
  8. mitotic nuclear envelope disassembly Source: Reactome
  9. mRNA transport Source: UniProtKB-KW
  10. protein transport Source: UniProtKB-KW
  11. regulation of glucose transport Source: Reactome
  12. small molecule metabolic process Source: Reactome
  13. transmembrane transport Source: Reactome
  14. viral process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, Mitosis, mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_115831. ISG15 antiviral mechanism.
REACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
REACT_6190. Rev-mediated nuclear export of HIV RNA.
REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_682. Mitotic Prometaphase.
REACT_7991. Vpr-mediated nuclear import of PICs.
REACT_9395. Nuclear import of Rev protein.
SignaLinkiQ8NFH3.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin Nup43
Alternative name(s):
Nup107-160 subcomplex subunit Nup43
p42
Gene namesi
Name:NUP43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21182. NUP43.

Subcellular locationi

Chromosomecentromerekinetochore. Nucleusnuclear pore complex 2 Publications

GO - Cellular componenti

  1. condensed chromosome kinetochore Source: UniProtKB-SubCell
  2. cytosol Source: Reactome
  3. nuclear envelope Source: Reactome
  4. nuclear pore outer ring Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134930788.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Nucleoporin Nup43PRO_0000051111Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8NFH3.
PaxDbiQ8NFH3.
PRIDEiQ8NFH3.

PTM databases

PhosphoSiteiQ8NFH3.

Expressioni

Gene expression databases

ArrayExpressiQ8NFH3.
BgeeiQ8NFH3.
CleanExiHS_NUP43.
GenevestigatoriQ8NFH3.

Organism-specific databases

HPAiHPA027126.
HPA027291.
HPA028500.

Interactioni

Subunit structurei

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13.2 Publications

Protein-protein interaction databases

BioGridi131544. 17 interactions.
IntActiQ8NFH3. 5 interactions.
MINTiMINT-4535305.
STRINGi9606.ENSP00000342262.

Structurei

Secondary structure

1
380
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 84
Beta strandi10 – 189
Beta strandi31 – 4818
Beta strandi66 – 7510
Beta strandi77 – 9216
Beta strandi97 – 1026
Turni104 – 1063
Beta strandi109 – 1157
Beta strandi118 – 1203
Beta strandi134 – 1407
Beta strandi143 – 1486
Beta strandi151 – 1577
Beta strandi164 – 1685
Beta strandi175 – 1828
Beta strandi185 – 1906
Beta strandi193 – 1997
Beta strandi203 – 2053
Beta strandi208 – 2125
Beta strandi214 – 2174
Beta strandi220 – 2256
Beta strandi232 – 2376
Beta strandi242 – 2465
Beta strandi254 – 2574
Beta strandi264 – 2696
Beta strandi276 – 2816
Beta strandi286 – 2905
Beta strandi341 – 3444
Beta strandi353 – 3597
Beta strandi362 – 3676
Beta strandi370 – 3767

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I79X-ray1.75A/B1-380[»]
ProteinModelPortaliQ8NFH3.
SMRiQ8NFH3. Positions 4-380.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati8 – 5750WD 1Add
BLAST
Repeati72 – 11039WD 2Add
BLAST
Repeati127 – 16640WD 3Add
BLAST
Repeati170 – 20839WD 4Add
BLAST
Repeati215 – 25541WD 5Add
BLAST
Repeati259 – 29941WD 6Add
BLAST

Sequence similaritiesi

Contains 6 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG270547.
HOGENOMiHOG000007964.
HOVERGENiHBG052696.
InParanoidiQ8NFH3.
KOiK14305.
OMAiQWTAAHY.
OrthoDBiEOG7Z3F4F.
PhylomeDBiQ8NFH3.
TreeFamiTF321692.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NFH3-1 [UniParc]FASTAAdd to Basket

« Hide

MEEIYAKFVS QKISKTRWRP LPPGSLQTAE TFATGSWDNE ENYISLWSIG    50
DFGNLDSDGG FEGDHQLLCD IRHHGDVMDL QFFDQERIVA ASSTGCVTVF 100
LHHPNNQTLS VNQQWTTAHY HTGPGSPSYS SAPCTGVVCN NPEIVTVGED 150
GRINLFRADH KEAVRTIDNA DSSTLHAVTF LRTPEILTVN SIGQLKIWDF 200
RQQGNEPSQI LSLTGDRVPL HCVDRHPNQQ HVVATGGQDG MLSIWDVRQG 250
TMPVSLLKAH EAEMWEVHFH PSNPEHLFTC SEDGSLWHWD ASTDVPEKSS 300
LFHQGGRSST FLSHSISNQA NVHQSVISSW LSTDPAKDRI EITSLLPSRS 350
LSVNTLDVLG PCLVCGTDAE AIYVTRHLFS 380
Length:380
Mass (Da):42,151
Last modified:October 1, 2002 - v1
Checksum:iEE44714B8E5BFB42
GO

Sequence cautioni

The sequence BAB14536.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti247 – 2471V → A in BAB14536. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF514997 mRNA. Translation: AAM76708.1.
BC065028 mRNA. Translation: AAH65028.1.
AK023349 mRNA. Translation: BAB14536.1. Different initiation.
CCDSiCCDS5218.1.
RefSeqiNP_942590.1. NM_198887.2.
UniGeneiHs.510375.

Genome annotation databases

EnsembliENST00000340413; ENSP00000342262; ENSG00000120253.
ENST00000460354; ENSP00000432401; ENSG00000120253.
GeneIDi348995.
KEGGihsa:348995.
UCSCiuc003qmz.3. human.

Polymorphism databases

DMDMi27923819.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF514997 mRNA. Translation: AAM76708.1 .
BC065028 mRNA. Translation: AAH65028.1 .
AK023349 mRNA. Translation: BAB14536.1 . Different initiation.
CCDSi CCDS5218.1.
RefSeqi NP_942590.1. NM_198887.2.
UniGenei Hs.510375.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4I79 X-ray 1.75 A/B 1-380 [» ]
ProteinModelPortali Q8NFH3.
SMRi Q8NFH3. Positions 4-380.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131544. 17 interactions.
IntActi Q8NFH3. 5 interactions.
MINTi MINT-4535305.
STRINGi 9606.ENSP00000342262.

PTM databases

PhosphoSitei Q8NFH3.

Polymorphism databases

DMDMi 27923819.

Proteomic databases

MaxQBi Q8NFH3.
PaxDbi Q8NFH3.
PRIDEi Q8NFH3.

Protocols and materials databases

DNASUi 348995.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340413 ; ENSP00000342262 ; ENSG00000120253 .
ENST00000460354 ; ENSP00000432401 ; ENSG00000120253 .
GeneIDi 348995.
KEGGi hsa:348995.
UCSCi uc003qmz.3. human.

Organism-specific databases

CTDi 348995.
GeneCardsi GC06M150087.
HGNCi HGNC:21182. NUP43.
HPAi HPA027126.
HPA027291.
HPA028500.
MIMi 608141. gene.
neXtProti NX_Q8NFH3.
PharmGKBi PA134930788.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG270547.
HOGENOMi HOG000007964.
HOVERGENi HBG052696.
InParanoidi Q8NFH3.
KOi K14305.
OMAi QWTAAHY.
OrthoDBi EOG7Z3F4F.
PhylomeDBi Q8NFH3.
TreeFami TF321692.

Enzyme and pathway databases

Reactomei REACT_115831. ISG15 antiviral mechanism.
REACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
REACT_6190. Rev-mediated nuclear export of HIV RNA.
REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_682. Mitotic Prometaphase.
REACT_7991. Vpr-mediated nuclear import of PICs.
REACT_9395. Nuclear import of Rev protein.
SignaLinki Q8NFH3.

Miscellaneous databases

GeneWikii NUP43.
GenomeRNAii 348995.
NextBioi 99471.
PROi Q8NFH3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8NFH3.
Bgeei Q8NFH3.
CleanExi HS_NUP43.
Genevestigatori Q8NFH3.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 2 hits.
[Graphical view ]
SMARTi SM00320. WD40. 5 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Proteomic analysis of the mammalian nuclear pore complex."
    Cronshaw J.M., Krutchinsky A.N., Zhang W., Chait B.T., Matunis M.J.
    J. Cell Biol. 158:915-927(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 247-380.
    Tissue: Ovarian carcinoma.
  4. "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis."
    Loieodice I., Alves A., Rabut G., Van Overbeek M., Ellenberg J., Sibarita J.-B., Doye V.
    Mol. Biol. Cell 15:3333-3344(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NUP107-160 COMPLEX, SUBCELLULAR LOCATION.
  5. "The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions."
    Zuccolo M., Alves A., Galy V., Bolhy S., Formstecher E., Racine V., Sibarita J.-B., Fukagawa T., Shiekhattar R., Yen T., Doye V.
    EMBO J. 26:1853-1864(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE NUP107-160 COMPLEX.
  6. "Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex."
    Glavy J.S., Krutchinsky A.N., Cristea I.M., Berke I.C., Boehmer T., Blobel G., Chait B.T.
    Proc. Natl. Acad. Sci. U.S.A. 104:3811-3816(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE NUP107-160 COMPLEX.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNUP43_HUMAN
AccessioniPrimary (citable) accession number: Q8NFH3
Secondary accession number(s): Q9H8S0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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