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Protein

Nucleoporin Nup43

Gene

NUP43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.1 Publication

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, Mitosis, mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-68877 Mitotic Prometaphase
SignaLinkiQ8NFH3

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin Nup43
Alternative name(s):
Nup107-160 subcomplex subunit Nup43
p42
Gene namesi
Name:NUP43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000120253.13
HGNCiHGNC:21182 NUP43
MIMi608141 gene
neXtProtiNX_Q8NFH3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi348995
OpenTargetsiENSG00000120253
PharmGKBiPA134930788

Polymorphism and mutation databases

BioMutaiNUP43
DMDMi27923819

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511111 – 380Nucleoporin Nup43Add BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8NFH3
MaxQBiQ8NFH3
PaxDbiQ8NFH3
PeptideAtlasiQ8NFH3
PRIDEiQ8NFH3

PTM databases

iPTMnetiQ8NFH3
PhosphoSitePlusiQ8NFH3

Expressioni

Gene expression databases

BgeeiENSG00000120253
CleanExiHS_NUP43
ExpressionAtlasiQ8NFH3 baseline and differential
GenevisibleiQ8NFH3 HS

Organism-specific databases

HPAiHPA027126
HPA027291
HPA028500

Interactioni

Subunit structurei

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13.2 Publications

Protein-protein interaction databases

BioGridi131544, 52 interactors
CORUMiQ8NFH3
IntActiQ8NFH3, 18 interactors
MINTiQ8NFH3
STRINGi9606.ENSP00000342262

Structurei

Secondary structure

1380
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 8Combined sources4
Beta strandi10 – 18Combined sources9
Beta strandi31 – 48Combined sources18
Beta strandi66 – 75Combined sources10
Beta strandi77 – 92Combined sources16
Beta strandi97 – 102Combined sources6
Turni104 – 106Combined sources3
Beta strandi109 – 115Combined sources7
Beta strandi118 – 120Combined sources3
Beta strandi134 – 140Combined sources7
Beta strandi143 – 148Combined sources6
Beta strandi151 – 157Combined sources7
Beta strandi164 – 168Combined sources5
Beta strandi175 – 182Combined sources8
Beta strandi185 – 190Combined sources6
Beta strandi193 – 199Combined sources7
Beta strandi203 – 205Combined sources3
Beta strandi208 – 212Combined sources5
Beta strandi214 – 217Combined sources4
Beta strandi220 – 225Combined sources6
Beta strandi232 – 237Combined sources6
Beta strandi242 – 246Combined sources5
Beta strandi254 – 257Combined sources4
Beta strandi264 – 269Combined sources6
Beta strandi276 – 281Combined sources6
Beta strandi286 – 290Combined sources5
Beta strandi341 – 344Combined sources4
Beta strandi353 – 359Combined sources7
Beta strandi362 – 367Combined sources6
Beta strandi370 – 376Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I79X-ray1.75A/B1-380[»]
5A9Qelectron microscopy23.000/9/I/R1-380[»]
ProteinModelPortaliQ8NFH3
SMRiQ8NFH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 57WD 1Add BLAST50
Repeati72 – 110WD 2Add BLAST39
Repeati127 – 166WD 3Add BLAST40
Repeati170 – 208WD 4Add BLAST39
Repeati215 – 255WD 5Add BLAST41
Repeati259 – 299WD 6Add BLAST41

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG4714 Eukaryota
ENOG410ZTD5 LUCA
GeneTreeiENSGT00390000004803
HOGENOMiHOG000007964
HOVERGENiHBG052696
InParanoidiQ8NFH3
KOiK14305
OMAiQFFDQER
OrthoDBiEOG091G0DV7
PhylomeDBiQ8NFH3
TreeFamiTF321692

Family and domain databases

InterProiView protein in InterPro
IPR037628 Nup43
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR22652 PTHR22652, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NFH3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEIYAKFVS QKISKTRWRP LPPGSLQTAE TFATGSWDNE ENYISLWSIG
60 70 80 90 100
DFGNLDSDGG FEGDHQLLCD IRHHGDVMDL QFFDQERIVA ASSTGCVTVF
110 120 130 140 150
LHHPNNQTLS VNQQWTTAHY HTGPGSPSYS SAPCTGVVCN NPEIVTVGED
160 170 180 190 200
GRINLFRADH KEAVRTIDNA DSSTLHAVTF LRTPEILTVN SIGQLKIWDF
210 220 230 240 250
RQQGNEPSQI LSLTGDRVPL HCVDRHPNQQ HVVATGGQDG MLSIWDVRQG
260 270 280 290 300
TMPVSLLKAH EAEMWEVHFH PSNPEHLFTC SEDGSLWHWD ASTDVPEKSS
310 320 330 340 350
LFHQGGRSST FLSHSISNQA NVHQSVISSW LSTDPAKDRI EITSLLPSRS
360 370 380
LSVNTLDVLG PCLVCGTDAE AIYVTRHLFS
Length:380
Mass (Da):42,151
Last modified:October 1, 2002 - v1
Checksum:iEE44714B8E5BFB42
GO
Isoform 2 (identifier: Q8NFH3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     168-264: DNADSSTLHA...SLLKAHEAEM → V

Note: No experimental confirmation available.
Show »
Length:284
Mass (Da):31,512
Checksum:iFF600FBC0ABC96D3
GO

Sequence cautioni

The sequence BAB14536 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti247V → A in BAB14536 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056167168 – 264DNADS…HEAEM → V in isoform 2. 1 PublicationAdd BLAST97

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF514997 mRNA Translation: AAM76708.1
AK023349 mRNA Translation: BAB14536.1 Different initiation.
AK304244 mRNA Translation: BAG65112.1
AL355312 Genomic DNA No translation available.
BC065028 mRNA Translation: AAH65028.1
CCDSiCCDS5218.1 [Q8NFH3-1]
RefSeqiNP_942590.1, NM_198887.2 [Q8NFH3-1]
UniGeneiHs.510375

Genome annotation databases

EnsembliENST00000340413; ENSP00000342262; ENSG00000120253 [Q8NFH3-1]
ENST00000367404; ENSP00000356374; ENSG00000120253 [Q8NFH3-2]
GeneIDi348995
KEGGihsa:348995
UCSCiuc003qmz.5 human [Q8NFH3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNUP43_HUMAN
AccessioniPrimary (citable) accession number: Q8NFH3
Secondary accession number(s): B4E2F0, Q9H8S0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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