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Protein

Nucleoporin Nup43

Gene

NUP43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.1 Publication

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. cell division Source: UniProtKB-KW
  3. chromosome segregation Source: UniProtKB-KW
  4. cytokine-mediated signaling pathway Source: Reactome
  5. gene expression Source: Reactome
  6. glucose transport Source: Reactome
  7. hexose transport Source: Reactome
  8. mitotic cell cycle Source: Reactome
  9. mitotic nuclear division Source: UniProtKB-KW
  10. mitotic nuclear envelope disassembly Source: Reactome
  11. mRNA transport Source: UniProtKB-KW
  12. pathogenesis Source: Reactome
  13. protein transport Source: UniProtKB-KW
  14. regulation of glucose transport Source: Reactome
  15. small molecule metabolic process Source: Reactome
  16. transmembrane transport Source: Reactome
  17. viral life cycle Source: Reactome
  18. viral process Source: Reactome
  19. viral transcription Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, Mitosis, mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_115831. ISG15 antiviral mechanism.
REACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
REACT_268530. Transcriptional regulation by small RNAs.
REACT_6190. Rev-mediated nuclear export of HIV RNA.
REACT_6354. Viral Messenger RNA Synthesis.
REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_682. Mitotic Prometaphase.
REACT_7991. Vpr-mediated nuclear import of PICs.
REACT_9395. Nuclear import of Rev protein.
SignaLinkiQ8NFH3.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin Nup43
Alternative name(s):
Nup107-160 subcomplex subunit Nup43
p42
Gene namesi
Name:NUP43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21182. NUP43.

Subcellular locationi

GO - Cellular componenti

  1. condensed chromosome kinetochore Source: UniProtKB-SubCell
  2. cytosol Source: Reactome
  3. nuclear envelope Source: Reactome
  4. nuclear pore outer ring Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134930788.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Nucleoporin Nup43PRO_0000051111Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8NFH3.
PaxDbiQ8NFH3.
PRIDEiQ8NFH3.

PTM databases

PhosphoSiteiQ8NFH3.

Expressioni

Gene expression databases

BgeeiQ8NFH3.
CleanExiHS_NUP43.
ExpressionAtlasiQ8NFH3. baseline and differential.
GenevestigatoriQ8NFH3.

Organism-specific databases

HPAiHPA027126.
HPA027291.
HPA028500.

Interactioni

Subunit structurei

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13.2 Publications

Protein-protein interaction databases

BioGridi131544. 30 interactions.
IntActiQ8NFH3. 5 interactions.
MINTiMINT-4535305.
STRINGi9606.ENSP00000342262.

Structurei

Secondary structure

1
380
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 84Combined sources
Beta strandi10 – 189Combined sources
Beta strandi31 – 4818Combined sources
Beta strandi66 – 7510Combined sources
Beta strandi77 – 9216Combined sources
Beta strandi97 – 1026Combined sources
Turni104 – 1063Combined sources
Beta strandi109 – 1157Combined sources
Beta strandi118 – 1203Combined sources
Beta strandi134 – 1407Combined sources
Beta strandi143 – 1486Combined sources
Beta strandi151 – 1577Combined sources
Beta strandi164 – 1685Combined sources
Beta strandi175 – 1828Combined sources
Beta strandi185 – 1906Combined sources
Beta strandi193 – 1997Combined sources
Beta strandi203 – 2053Combined sources
Beta strandi208 – 2125Combined sources
Beta strandi214 – 2174Combined sources
Beta strandi220 – 2256Combined sources
Beta strandi232 – 2376Combined sources
Beta strandi242 – 2465Combined sources
Beta strandi254 – 2574Combined sources
Beta strandi264 – 2696Combined sources
Beta strandi276 – 2816Combined sources
Beta strandi286 – 2905Combined sources
Beta strandi341 – 3444Combined sources
Beta strandi353 – 3597Combined sources
Beta strandi362 – 3676Combined sources
Beta strandi370 – 3767Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I79X-ray1.75A/B1-380[»]
ProteinModelPortaliQ8NFH3.
SMRiQ8NFH3. Positions 4-380.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati8 – 5750WD 1Add
BLAST
Repeati72 – 11039WD 2Add
BLAST
Repeati127 – 16640WD 3Add
BLAST
Repeati170 – 20839WD 4Add
BLAST
Repeati215 – 25541WD 5Add
BLAST
Repeati259 – 29941WD 6Add
BLAST

Sequence similaritiesi

Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG270547.
GeneTreeiENSGT00390000004803.
HOGENOMiHOG000007964.
HOVERGENiHBG052696.
InParanoidiQ8NFH3.
KOiK14305.
OMAiQWTAAHY.
OrthoDBiEOG7Z3F4F.
PhylomeDBiQ8NFH3.
TreeFamiTF321692.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NFH3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEIYAKFVS QKISKTRWRP LPPGSLQTAE TFATGSWDNE ENYISLWSIG
60 70 80 90 100
DFGNLDSDGG FEGDHQLLCD IRHHGDVMDL QFFDQERIVA ASSTGCVTVF
110 120 130 140 150
LHHPNNQTLS VNQQWTTAHY HTGPGSPSYS SAPCTGVVCN NPEIVTVGED
160 170 180 190 200
GRINLFRADH KEAVRTIDNA DSSTLHAVTF LRTPEILTVN SIGQLKIWDF
210 220 230 240 250
RQQGNEPSQI LSLTGDRVPL HCVDRHPNQQ HVVATGGQDG MLSIWDVRQG
260 270 280 290 300
TMPVSLLKAH EAEMWEVHFH PSNPEHLFTC SEDGSLWHWD ASTDVPEKSS
310 320 330 340 350
LFHQGGRSST FLSHSISNQA NVHQSVISSW LSTDPAKDRI EITSLLPSRS
360 370 380
LSVNTLDVLG PCLVCGTDAE AIYVTRHLFS
Length:380
Mass (Da):42,151
Last modified:September 30, 2002 - v1
Checksum:iEE44714B8E5BFB42
GO
Isoform 2 (identifier: Q8NFH3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     168-264: DNADSSTLHA...SLLKAHEAEM → V

Note: No experimental confirmation available.

Show »
Length:284
Mass (Da):31,512
Checksum:iFF600FBC0ABC96D3
GO

Sequence cautioni

The sequence BAB14536.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti247 – 2471V → A in BAB14536 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei168 – 26497DNADS…HEAEM → V in isoform 2. 1 PublicationVSP_056167Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF514997 mRNA. Translation: AAM76708.1.
AK023349 mRNA. Translation: BAB14536.1. Different initiation.
AK304244 mRNA. Translation: BAG65112.1.
AL355312 Genomic DNA. No translation available.
BC065028 mRNA. Translation: AAH65028.1.
CCDSiCCDS5218.1. [Q8NFH3-1]
RefSeqiNP_942590.1. NM_198887.2. [Q8NFH3-1]
UniGeneiHs.510375.

Genome annotation databases

EnsembliENST00000340413; ENSP00000342262; ENSG00000120253. [Q8NFH3-1]
ENST00000367404; ENSP00000356374; ENSG00000120253. [Q8NFH3-2]
GeneIDi348995.
KEGGihsa:348995.
UCSCiuc003qmz.3. human. [Q8NFH3-1]

Polymorphism databases

DMDMi27923819.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF514997 mRNA. Translation: AAM76708.1.
AK023349 mRNA. Translation: BAB14536.1. Different initiation.
AK304244 mRNA. Translation: BAG65112.1.
AL355312 Genomic DNA. No translation available.
BC065028 mRNA. Translation: AAH65028.1.
CCDSiCCDS5218.1. [Q8NFH3-1]
RefSeqiNP_942590.1. NM_198887.2. [Q8NFH3-1]
UniGeneiHs.510375.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I79X-ray1.75A/B1-380[»]
ProteinModelPortaliQ8NFH3.
SMRiQ8NFH3. Positions 4-380.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131544. 30 interactions.
IntActiQ8NFH3. 5 interactions.
MINTiMINT-4535305.
STRINGi9606.ENSP00000342262.

PTM databases

PhosphoSiteiQ8NFH3.

Polymorphism databases

DMDMi27923819.

Proteomic databases

MaxQBiQ8NFH3.
PaxDbiQ8NFH3.
PRIDEiQ8NFH3.

Protocols and materials databases

DNASUi348995.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340413; ENSP00000342262; ENSG00000120253. [Q8NFH3-1]
ENST00000367404; ENSP00000356374; ENSG00000120253. [Q8NFH3-2]
GeneIDi348995.
KEGGihsa:348995.
UCSCiuc003qmz.3. human. [Q8NFH3-1]

Organism-specific databases

CTDi348995.
GeneCardsiGC06M150045.
HGNCiHGNC:21182. NUP43.
HPAiHPA027126.
HPA027291.
HPA028500.
MIMi608141. gene.
neXtProtiNX_Q8NFH3.
PharmGKBiPA134930788.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG270547.
GeneTreeiENSGT00390000004803.
HOGENOMiHOG000007964.
HOVERGENiHBG052696.
InParanoidiQ8NFH3.
KOiK14305.
OMAiQWTAAHY.
OrthoDBiEOG7Z3F4F.
PhylomeDBiQ8NFH3.
TreeFamiTF321692.

Enzyme and pathway databases

ReactomeiREACT_115831. ISG15 antiviral mechanism.
REACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_163931. Nuclear Pore Complex (NPC) Disassembly.
REACT_268530. Transcriptional regulation by small RNAs.
REACT_6190. Rev-mediated nuclear export of HIV RNA.
REACT_6354. Viral Messenger RNA Synthesis.
REACT_6804. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_682. Mitotic Prometaphase.
REACT_7991. Vpr-mediated nuclear import of PICs.
REACT_9395. Nuclear import of Rev protein.
SignaLinkiQ8NFH3.

Miscellaneous databases

GeneWikiiNUP43.
GenomeRNAii348995.
NextBioi35477267.
PROiQ8NFH3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NFH3.
CleanExiHS_NUP43.
ExpressionAtlasiQ8NFH3. baseline and differential.
GenevestigatoriQ8NFH3.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Proteomic analysis of the mammalian nuclear pore complex."
    Cronshaw J.M., Krutchinsky A.N., Zhang W., Chait B.T., Matunis M.J.
    J. Cell Biol. 158:915-927(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 247-380 (ISOFORM 1).
    Tissue: Ovarian carcinoma and Trachea.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  5. "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis."
    Loieodice I., Alves A., Rabut G., Van Overbeek M., Ellenberg J., Sibarita J.-B., Doye V.
    Mol. Biol. Cell 15:3333-3344(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NUP107-160 COMPLEX, SUBCELLULAR LOCATION.
  6. "The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions."
    Zuccolo M., Alves A., Galy V., Bolhy S., Formstecher E., Racine V., Sibarita J.-B., Fukagawa T., Shiekhattar R., Yen T., Doye V.
    EMBO J. 26:1853-1864(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE NUP107-160 COMPLEX.
  7. "Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex."
    Glavy J.S., Krutchinsky A.N., Cristea I.M., Berke I.C., Boehmer T., Blobel G., Chait B.T.
    Proc. Natl. Acad. Sci. U.S.A. 104:3811-3816(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE NUP107-160 COMPLEX.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNUP43_HUMAN
AccessioniPrimary (citable) accession number: Q8NFH3
Secondary accession number(s): B4E2F0, Q9H8S0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 26, 2003
Last sequence update: September 30, 2002
Last modified: March 31, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.