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Q8NFF3

- Q8NFF3_HUMAN

UniProt

Q8NFF3 - Q8NFF3_HUMAN

Protein
Submitted name:

Pro-apoptotic protein BAKM variant

Gene

BAK

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: Ensembl
    2. aging Source: Ensembl
    3. apoptotic process involved in patterning of blood vessels Source: Ensembl
    4. B cell apoptotic process Source: Ensembl
    5. B cell homeostasis Source: Ensembl
    6. B cell negative selection Source: Ensembl
    7. blood vessel remodeling Source: Ensembl
    8. brain development Source: Ensembl
    9. cell proliferation Source: Ensembl
    10. endocrine pancreas development Source: Ensembl
    11. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    12. fibroblast apoptotic process Source: Ensembl
    13. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
    14. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: Ensembl
    15. limb morphogenesis Source: Ensembl
    16. mitochondrial fusion Source: Ensembl
    17. myeloid cell homeostasis Source: Ensembl
    18. negative regulation of cell proliferation Source: Ensembl
    19. negative regulation of endoplasmic reticulum calcium ion concentration Source: Ensembl
    20. negative regulation of gene expression Source: Ensembl
    21. negative regulation of peptidyl-serine phosphorylation Source: Ensembl
    22. organ regeneration Source: Ensembl
    23. positive regulation of apoptotic process Source: Ensembl
    24. positive regulation of calcium ion transport into cytosol Source: Ensembl
    25. positive regulation of release of cytochrome c from mitochondria Source: Ensembl
    26. post-embryonic camera-type eye morphogenesis Source: Ensembl
    27. regulation of cell cycle Source: Ensembl
    28. response to drug Source: Ensembl
    29. response to ethanol Source: Ensembl
    30. response to fungus Source: Ensembl
    31. response to gamma radiation Source: Ensembl
    32. response to hydrogen peroxide Source: Ensembl
    33. response to mycotoxin Source: Ensembl
    34. response to organic cyclic compound Source: Ensembl
    35. response to UV-C Source: Ensembl
    36. thymocyte apoptotic process Source: Ensembl
    37. vagina development Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Pro-apoptotic protein BAKM variantImported
    Gene namesi
    Name:BAKImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. endoplasmic reticulum Source: Ensembl
    3. mitochondrial membrane Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiQ8NFF3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NFF3.
    BgeeiQ8NFF3.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1448621.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NFF3.
    SMRiQ8NFF3. Positions 23-163.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000006521.
    HOVERGENiHBG002674.

    Family and domain databases

    InterProiIPR026308. BAK.
    IPR002475. Bcl2-like.
    IPR020717. Bcl2_BH1_motif_CS.
    IPR020726. Bcl2_BH2_motif_CS.
    IPR020728. Bcl2_BH3_motif_CS.
    IPR026298. Blc2_fam.
    [Graphical view]
    PANTHERiPTHR11256. PTHR11256. 1 hit.
    PTHR11256:SF41. PTHR11256:SF41. 1 hit.
    PfamiPF00452. Bcl-2. 1 hit.
    [Graphical view]
    PRINTSiPR01862. BCL2FAMILY.
    PROSITEiPS50062. BCL2_FAMILY. 1 hit.
    PS01080. BH1. 1 hit.
    PS01258. BH2. 1 hit.
    PS01259. BH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NFF3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASGQGPGPP RQECGEPALP SASEEQVAQD TEEVFRSYVF YRHQQPSSTM    50
    GQVGRQLAII GDDINRRYDS EFQTMLQHLQ PTAENAYEYF TKIATSLFES 100
    GINWGRVVAL LGFGYRLALH VYQHGLTGFL GQVTRFVVDF MLHHCIARWI 150
    AQRGGWVAAL NLGNGPILNV LVVLGVVLLG QFVVRRFFKS 190
    Length:190
    Mass (Da):21,231
    Last modified:October 1, 2002 - v1
    Checksum:iA9D4EB8526D0897B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF520590 mRNA. Translation: AAM74949.1.
    UniGeneiHs.485139.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF520590 mRNA. Translation: AAM74949.1 .
    UniGenei Hs.485139.

    3D structure databases

    ProteinModelPortali Q8NFF3.
    SMRi Q8NFF3. Positions 23-163.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1448621.

    Proteomic databases

    PRIDEi Q8NFF3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOGENOMi HOG000006521.
    HOVERGENi HBG002674.

    Gene expression databases

    ArrayExpressi Q8NFF3.
    Bgeei Q8NFF3.

    Family and domain databases

    InterProi IPR026308. BAK.
    IPR002475. Bcl2-like.
    IPR020717. Bcl2_BH1_motif_CS.
    IPR020726. Bcl2_BH2_motif_CS.
    IPR020728. Bcl2_BH3_motif_CS.
    IPR026298. Blc2_fam.
    [Graphical view ]
    PANTHERi PTHR11256. PTHR11256. 1 hit.
    PTHR11256:SF41. PTHR11256:SF41. 1 hit.
    Pfami PF00452. Bcl-2. 1 hit.
    [Graphical view ]
    PRINTSi PR01862. BCL2FAMILY.
    PROSITEi PS50062. BCL2_FAMILY. 1 hit.
    PS01080. BH1. 1 hit.
    PS01258. BH2. 1 hit.
    PS01259. BH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Ma J.
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ8NFF3_HUMAN
    AccessioniPrimary (citable) accession number: Q8NFF3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.