Q8NFF3 (Q8NFF3_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Pro-apoptotic protein BAKM variant EMBL AAM74949.1

Gene names

Name:

BAK EMBL AAM74949.1

Organism

Homo sapiens (Human) EMBL AAM74949.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	B cell apoptotic process Inferred from electronic annotation. Source: Compara B cell homeostasis Inferred from electronic annotation. Source: Compara B cell negative selection Inferred from electronic annotation. Source: Compara activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Inferred from electronic annotation. Source: Compara aging Inferred from electronic annotation. Source: Compara blood vessel remodeling Inferred from electronic annotation. Source: Compara brain development Inferred from electronic annotation. Source: Compara cell proliferation Inferred from electronic annotation. Source: Compara endocrine pancreas development Inferred from electronic annotation. Source: Compara intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Inferred from electronic annotation. Source: Compara limb morphogenesis Inferred from electronic annotation. Source: Compara mitochondrial fusion Inferred from electronic annotation. Source: Compara myeloid cell homeostasis Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of gene expression Inferred from electronic annotation. Source: Compara negative regulation of peptidyl-serine phosphorylation Inferred from electronic annotation. Source: Compara organ regeneration Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of calcium ion transport into cytosol Inferred from electronic annotation. Source: Compara positive regulation of release of cytochrome c from mitochondria Inferred from electronic annotation. Source: Compara post-embryonic camera-type eye morphogenesis Inferred from electronic annotation. Source: Compara reduction of endoplasmic reticulum calcium ion concentration Inferred from electronic annotation. Source: Compara regulation of cell cycle Inferred from electronic annotation. Source: Compara response to UV-C Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to ethanol Inferred from electronic annotation. Source: Compara response to fungus Inferred from electronic annotation. Source: Compara response to gamma radiation Inferred from electronic annotation. Source: Compara response to hydrogen peroxide Inferred from electronic annotation. Source: Compara response to mycotoxin Inferred from electronic annotation. Source: Compara response to organic cyclic compound Inferred from electronic annotation. Source: Compara vagina development Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Inferred from electronic annotation. Source: Compara endoplasmic reticulum Inferred from electronic annotation. Source: Compara mitochondrial membrane Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8NFF3 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: A9D4EB8526D0897B	FASTA	190	21,231
	10 20 30 40 50 60 MASGQGPGPP RQECGEPALP SASEEQVAQD TEEVFRSYVF YRHQQPSSTM GQVGRQLAII 70 80 90 100 110 120 GDDINRRYDS EFQTMLQHLQ PTAENAYEYF TKIATSLFES GINWGRVVAL LGFGYRLALH 130 140 150 160 170 180 VYQHGLTGFL GQVTRFVVDF MLHHCIARWI AQRGGWVAAL NLGNGPILNV LVVLGVVLLG 190 QFVVRRFFKS

References

[1]	Ma J. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF520590 mRNA. Translation: AAM74949.1.
IPI	IPI00386229.
UniGene	Hs.485139.
3D structure databases
HSSP	HSSP built from PDB template 1BXL based on UniProtKB Q16611.
ProteinModelPortal	Q8NFF3.
SMR	Q8NFF3. Positions 23-163.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1448621.
STRING	Q8NFF3.
Proteomic databases
PRIDE	Q8NFF3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOGENOM	HOG000006521.
HOVERGEN	HBG002674.
Gene expression databases
ArrayExpress	Q8NFF3.
Bgee	Q8NFF3.
Family and domain databases
InterPro	IPR026308. BAK. IPR002475. Bcl2-like. IPR020717. Bcl2_BH1_motif_CS. IPR020726. Bcl2_BH2_motif_CS. IPR020728. Bcl2_BH3_motif_CS. IPR026298. Blc2_fam. [Graphical view]
PANTHER	PTHR11256. PTHR11256. 1 hit. PTHR11256:SF8. PTHR11256:SF8. 1 hit.
Pfam	PF00452. Bcl-2. 1 hit. [Graphical view]
PRINTS	PR01862. BCL2FAMILY.
PROSITE	PS50062. BCL2_FAMILY. 1 hit. PS01080. BH1. 1 hit. PS01258. BH2. 1 hit. PS01259. BH3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8NFF3_HUMAN

Accession

Primary (citable) accession number: Q8NFF3

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.