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Q8NFF3

- Q8NFF3_HUMAN

UniProt

Q8NFF3 - Q8NFF3_HUMAN

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Protein
Submitted name: Pro-apoptotic protein BAKM variant
Gene
BAK
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. B cell apoptotic process Source: Ensembl
  2. B cell homeostasis Source: Ensembl
  3. B cell negative selection Source: Ensembl
  4. activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: Ensembl
  5. aging Source: Ensembl
  6. apoptotic process involved in patterning of blood vessels Source: Ensembl
  7. blood vessel remodeling Source: Ensembl
  8. brain development Source: Ensembl
  9. cell proliferation Source: Ensembl
  10. endocrine pancreas development Source: Ensembl
  11. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  12. fibroblast apoptotic process Source: Ensembl
  13. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  14. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: Ensembl
  15. limb morphogenesis Source: Ensembl
  16. mitochondrial fusion Source: Ensembl
  17. myeloid cell homeostasis Source: Ensembl
  18. negative regulation of cell proliferation Source: Ensembl
  19. negative regulation of endoplasmic reticulum calcium ion concentration Source: Ensembl
  20. negative regulation of gene expression Source: Ensembl
  21. negative regulation of peptidyl-serine phosphorylation Source: Ensembl
  22. organ regeneration Source: Ensembl
  23. positive regulation of apoptotic process Source: Ensembl
  24. positive regulation of calcium ion transport into cytosol Source: Ensembl
  25. positive regulation of release of cytochrome c from mitochondria Source: Ensembl
  26. post-embryonic camera-type eye morphogenesis Source: Ensembl
  27. regulation of cell cycle Source: Ensembl
  28. response to UV-C Source: Ensembl
  29. response to drug Source: Ensembl
  30. response to ethanol Source: Ensembl
  31. response to fungus Source: Ensembl
  32. response to gamma radiation Source: Ensembl
  33. response to hydrogen peroxide Source: Ensembl
  34. response to mycotoxin Source: Ensembl
  35. response to organic cyclic compound Source: Ensembl
  36. thymocyte apoptotic process Source: Ensembl
  37. vagina development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Pro-apoptotic protein BAKM variantImported
Gene namesi
Name:BAKImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. endoplasmic reticulum Source: Ensembl
  3. mitochondrial membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ8NFF3.

Expressioni

Gene expression databases

ArrayExpressiQ8NFF3.
BgeeiQ8NFF3.

Interactioni

Protein-protein interaction databases

MINTiMINT-1448621.

Structurei

3D structure databases

ProteinModelPortaliQ8NFF3.
SMRiQ8NFF3. Positions 23-163.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000006521.
HOVERGENiHBG002674.

Family and domain databases

InterProiIPR026308. BAK.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR020728. Bcl2_BH3_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF41. PTHR11256:SF41. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PRINTSiPR01862. BCL2FAMILY.
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01259. BH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NFF3-1 [UniParc]FASTAAdd to Basket

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MASGQGPGPP RQECGEPALP SASEEQVAQD TEEVFRSYVF YRHQQPSSTM    50
GQVGRQLAII GDDINRRYDS EFQTMLQHLQ PTAENAYEYF TKIATSLFES 100
GINWGRVVAL LGFGYRLALH VYQHGLTGFL GQVTRFVVDF MLHHCIARWI 150
AQRGGWVAAL NLGNGPILNV LVVLGVVLLG QFVVRRFFKS 190
Length:190
Mass (Da):21,231
Last modified:October 1, 2002 - v1
Checksum:iA9D4EB8526D0897B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF520590 mRNA. Translation: AAM74949.1.
UniGeneiHs.485139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF520590 mRNA. Translation: AAM74949.1 .
UniGenei Hs.485139.

3D structure databases

ProteinModelPortali Q8NFF3.
SMRi Q8NFF3. Positions 23-163.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1448621.

Proteomic databases

PRIDEi Q8NFF3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOGENOMi HOG000006521.
HOVERGENi HBG002674.

Gene expression databases

ArrayExpressi Q8NFF3.
Bgeei Q8NFF3.

Family and domain databases

InterProi IPR026308. BAK.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR020728. Bcl2_BH3_motif_CS.
IPR026298. Blc2_fam.
[Graphical view ]
PANTHERi PTHR11256. PTHR11256. 1 hit.
PTHR11256:SF41. PTHR11256:SF41. 1 hit.
Pfami PF00452. Bcl-2. 1 hit.
[Graphical view ]
PRINTSi PR01862. BCL2FAMILY.
PROSITEi PS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01259. BH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Ma J.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8NFF3_HUMAN
AccessioniPrimary (citable) accession number: Q8NFF3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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