Q8NFF2 (NCKX4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium/potassium/calcium exchanger 4

Alternative name(s):
Na(+)/K(+)/Ca(2+)-exchange protein 4
Solute carrier family 24 member 4

Gene names

Name:	SLC24A4
Synonyms:	NCKX4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	622 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transports 1 Ca2+ and 1 K+ in exchange for 4 Na+.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed abundantly in all regions of the brain, aorta, lung and thymus. Expressed at lower levels in the stomach and intestine.
Polymorphism	Genetic variants in SLC24A4 define the skin/hair/eye pigmentation variation locus 6 (SHEP6) [MIM:210750]. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighter pigmentation with increasing distance from the equator. By contrast, the majority of variation in human eye and hair color is found among individuals of European ancestry, with most other human populations fixed for brown eyes and black hair.
Sequence similarities	Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily.
Caution	It is uncertain whether Met-1 or Met-18 is the initiator.
Sequence caution	The sequence AAH69653.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAM76070.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAM76071.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC04715.1 differs from that shown. Reason: Probable cloning artifact. The sequence CAD38903.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Antiport Calcium transport Ion transport Potassium transport Sodium transport Symport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Potassium Sodium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	calcium ion transport Inferred from electronic annotation. Source: UniProtKB-KW ion transport Traceable author statement. Source: Reactome potassium ion transport Inferred from electronic annotation. Source: UniProtKB-KW sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW transmembrane transport Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	antiporter activity Inferred from electronic annotation. Source: UniProtKB-KW symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NFF2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NFF2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.

Isoform 3 (identifier: Q8NFF2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     275-293: Missing.

Isoform 4 (identifier: Q8NFF2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-109: Missing.
     172-210: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 38	38	Potential
	Chain	39 – 622	584	Sodium/potassium/calcium exchanger 4		PRO_0000019373
Regions
	Topological domain	39 – 97	59	Extracellular Potential
	Transmembrane	98 – 118	21	Helical; Potential
	Topological domain	119 – 172	54	Cytoplasmic Potential
	Transmembrane	173 – 193	21	Helical; Potential
	Topological domain	194 – 200	7	Extracellular Potential
	Transmembrane	201 – 221	21	Helical; Potential
	Topological domain	222 – 224	3	Cytoplasmic Potential
	Transmembrane	225 – 245	21	Helical; Potential
	Topological domain	246 – 424	179	Extracellular Potential
	Transmembrane	425 – 445	21	Helical; Potential
	Topological domain	446 – 457	12	Cytoplasmic Potential
	Transmembrane	458 – 478	21	Helical; Potential
	Topological domain	479	1	Extracellular Potential
	Transmembrane	480 – 500	21	Helical; Potential
	Topological domain	501 – 526	26	Cytoplasmic Potential
	Transmembrane	527 – 547	21	Helical; Potential
	Topological domain	548 – 557	10	Extracellular Potential
	Transmembrane	558 – 578	21	Helical; Potential
	Topological domain	579 – 586	8	Cytoplasmic Potential
	Transmembrane	587 – 607	21	Helical; Potential
	Topological domain	608 – 622	15	Extracellular Potential
	Repeat	139 – 179	41	Alpha-1
	Repeat	495 – 526	32	Alpha-2
	Compositional bias	395 – 406	12	Poly-Pro
Amino acid modifications
	Glycosylation	69	1	N-linked (GlcNAc...) Potential
	Glycosylation	76	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 109	109	Missing in isoform 4.		VSP_008370
	Alternative sequence	1 – 64	64	Missing in isoform 2.		VSP_008369
	Alternative sequence	172 – 210	39	Missing in isoform 4.		VSP_008371
	Alternative sequence	275 – 293	19	Missing in isoform 3.		VSP_008372
	Natural variant	613	1	V → I. Corresponds to variant rs4900130 [ dbSNP | Ensembl ].		VAR_042664
Experimental info
	Sequence conflict	444	1	C → S in BAC04715. Ref.2
	Sequence conflict	560	1	Y → H in BAG58108. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 00D69370E55EE388	FASTA	622	69,042
	10 20 30 40 50 60 MALRGTLRPL KVRRRREMLP QQVGFVCAVL ALVCCASGLF GSLGHKTASA SKRVLPDTWR 70 80 90 100 110 120 NRKLMAPVNG TQTAKNCTDP AIHEFPTDLF SNKERQHGAV LLHILGALYM FYALAIVCDD 130 140 150 160 170 180 FFVPSLEKIC ERLHLSEDVA GATFMAAGSS TPELFASVIG VFITHGDVGV GTIVGSAVFN 190 200 210 220 230 240 ILCIIGVCGL FAGQVVRLTW WAVCRDSVYY TISVIVLIVF IYDEQIVWWE GLVLIILYVF 250 260 270 280 290 300 YILIMKYNVK MQAFFTVKQK SIANGNPVNS ELEAGNDFYD GSYDDPSVPL LGQVKEKPQY 310 320 330 340 350 360 GKNPVVMVDE IMSSSPPKFT FPEAGLRIMI TNKFGPRTRL RMASRIIINE RQRLINSANG 370 380 390 400 410 420 VSSKPLQNGR HENIENGNVP VENPEDPQQN QEQQPPPQPP PPEPEPVEAD FLSPFSVPEA 430 440 450 460 470 480 RGDKVKWVFT WPLIFLLCVT IPNCSKPRWE KFFMVTFITA TLWIAVFSYI MVWLVTIIGY 490 500 510 520 530 540 TLGIPDVIMG ITFLAAGTSV PDCMASLIVA RQGLGDMAVS NTIGSNVFDI LVGLGVPWGL 550 560 570 580 590 600 QTMVVNYGST VKINSRGLVY SVVLLLGSVA LTVLGIHLNK WRLDRKLGVY VLVLYAIFLC 610 620 FSIMIEFNVF TFVNLPMCRE DD
	Isoform 2 [UniParc]. Checksum: 3DC0E1DFBC5D7828	FASTA	558	61,938
	10 20 30 40 50 60 MAPVNGTQTA KNCTDPAIHE FPTDLFSNKE RQHGAVLLHI LGALYMFYAL AIVCDDFFVP 70 80 90 100 110 120 SLEKICERLH LSEDVAGATF MAAGSSTPEL FASVIGVFIT HGDVGVGTIV GSAVFNILCI 130 140 150 160 170 180 IGVCGLFAGQ VVRLTWWAVC RDSVYYTISV IVLIVFIYDE QIVWWEGLVL IILYVFYILI 190 200 210 220 230 240 MKYNVKMQAF FTVKQKSIAN GNPVNSELEA GNDFYDGSYD DPSVPLLGQV KEKPQYGKNP 250 260 270 280 290 300 VVMVDEIMSS SPPKFTFPEA GLRIMITNKF GPRTRLRMAS RIIINERQRL INSANGVSSK 310 320 330 340 350 360 PLQNGRHENI ENGNVPVENP EDPQQNQEQQ PPPQPPPPEP EPVEADFLSP FSVPEARGDK 370 380 390 400 410 420 VKWVFTWPLI FLLCVTIPNC SKPRWEKFFM VTFITATLWI AVFSYIMVWL VTIIGYTLGI 430 440 450 460 470 480 PDVIMGITFL AAGTSVPDCM ASLIVARQGL GDMAVSNTIG SNVFDILVGL GVPWGLQTMV 490 500 510 520 530 540 VNYGSTVKIN SRGLVYSVVL LLGSVALTVL GIHLNKWRLD RKLGVYVLVL YAIFLCFSIM 550 IEFNVFTFVN LPMCREDD
	Isoform 3 [UniParc]. Checksum: C8A7D3637BF861F8	FASTA	603	67,001
	10 20 30 40 50 60 MALRGTLRPL KVRRRREMLP QQVGFVCAVL ALVCCASGLF GSLGHKTASA SKRVLPDTWR 70 80 90 100 110 120 NRKLMAPVNG TQTAKNCTDP AIHEFPTDLF SNKERQHGAV LLHILGALYM FYALAIVCDD 130 140 150 160 170 180 FFVPSLEKIC ERLHLSEDVA GATFMAAGSS TPELFASVIG VFITHGDVGV GTIVGSAVFN 190 200 210 220 230 240 ILCIIGVCGL FAGQVVRLTW WAVCRDSVYY TISVIVLIVF IYDEQIVWWE GLVLIILYVF 250 260 270 280 290 300 YILIMKYNVK MQAFFTVKQK SIANGNPVNS ELEAVKEKPQ YGKNPVVMVD EIMSSSPPKF 310 320 330 340 350 360 TFPEAGLRIM ITNKFGPRTR LRMASRIIIN ERQRLINSAN GVSSKPLQNG RHENIENGNV 370 380 390 400 410 420 PVENPEDPQQ NQEQQPPPQP PPPEPEPVEA DFLSPFSVPE ARGDKVKWVF TWPLIFLLCV 430 440 450 460 470 480 TIPNCSKPRW EKFFMVTFIT ATLWIAVFSY IMVWLVTIIG YTLGIPDVIM GITFLAAGTS 490 500 510 520 530 540 VPDCMASLIV ARQGLGDMAV SNTIGSNVFD ILVGLGVPWG LQTMVVNYGS TVKINSRGLV 550 560 570 580 590 600 YSVVLLLGSV ALTVLGIHLN KWRLDRKLGV YVLVLYAIFL CFSIMIEFNV FTFVNLPMCR EDD
	Isoform 4 [UniParc]. Checksum: 5C9395536A220F7A	FASTA	474	52,760
	10 20 30 40 50 60 MFYALAIVCD DFFVPSLEKI CERLHLSEDV AGATFMAAGS STPELFASVI GVFITHGDVG 70 80 90 100 110 120 VGTISVIVLI VFIYDEQIVW WEGLVLIILY VFYILIMKYN VKMQAFFTVK QKSIANGNPV 130 140 150 160 170 180 NSELEAGNDF YDGSYDDPSV PLLGQVKEKP QYGKNPVVMV DEIMSSSPPK FTFPEAGLRI 190 200 210 220 230 240 MITNKFGPRT RLRMASRIII NERQRLINSA NGVSSKPLQN GRHENIENGN VPVENPEDPQ 250 260 270 280 290 300 QNQEQQPPPQ PPPPEPEPVE ADFLSPFSVP EARGDKVKWV FTWPLIFLLC VTIPNCSKPR 310 320 330 340 350 360 WEKFFMVTFI TATLWIAVFS YIMVWLVTII GYTLGIPDVI MGITFLAAGT SVPDCMASLI 370 380 390 400 410 420 VARQGLGDMA VSNTIGSNVF DILVGLGVPW GLQTMVVNYG STVKINSRGL VYSVVLLLGS 430 440 450 460 470 VALTVLGIHL NKWRLDRKLG VYVLVLYAIF LCFSIMIEFN VFTFVNLPMC REDD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a fourth member of the potassium-dependent sodium-calcium exchanger gene family, NCKX4." Li X.-F., Kraev A.S., Lytton J. J. Biol. Chem. 277:48410-48417(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [MRNA] OF 10-622 (ISOFORMS 1 AND 3).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-474 (ISOFORM 4). Tissue: Brain.
[3]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-622 (ISOFORM 1).
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 294-622 (ISOFORM 1). Tissue: Testis.
[7]	"Genetic determinants of hair, eye and skin pigmentation in Europeans." Sulem P., Gudbjartsson D.F., Stacey S.N., Helgason A., Rafnar T., Magnusson K.P., Manolescu A., Karason A., Palsson A., Thorleifsson G., Jakobsdottir M., Steinberg S., Palsson S., Jonasson F., Sigurgeirsson B., Thorisdottir K., Ragnarsson R., Benediktsdottir K.R. , Aben K.K., Kiemeney L.A., Olafsson J.H., Gulcher J., Kong A., Thorsteinsdottir U., Stefansson K. Nat. Genet. 39:1443-1452(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN SHEP6.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF520704 mRNA. Translation: AAM76070.1. Different initiation. AF520705 mRNA. Translation: AAM76071.1. Different initiation. AF520706 mRNA. Translation: AAM76072.1. AK096171 mRNA. Translation: BAC04715.1. Sequence problems. AK295059 mRNA. Translation: BAG58108.1. AL118559 Genomic DNA. No translation available. CH471061 Genomic DNA. Translation: EAW81485.1. BC069653 mRNA. Translation: AAH69653.1. Different initiation. AL834225 mRNA. Translation: CAD38903.1. Different initiation.
IPI	IPI00177492. IPI00254233. IPI00254236. IPI00982723.
RefSeq	NP_705932.2. NM_153646.3. NP_705933.2. NM_153647.3. NP_705934.1. NM_153648.3.
UniGene	Hs.385530.
3D structure databases
ProteinModelPortal	Q8NFF2.
SMR	Q8NFF2. Positions 120-242, 452-536.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000298877.
Protein family/group databases
TCDB	2.A.19.4.5. Ca2+:cation antiporter (CaCA) family.
Polymorphism databases
DMDM	37081118.
Proteomic databases
PaxDb	Q8NFF2.
PRIDE	Q8NFF2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298877; ENSP00000298877; ENSG00000140090. ENST00000351924; ENSP00000337789; ENSG00000140090. ENST00000393265; ENSP00000376948; ENSG00000140090. ENST00000531433; ENSP00000433302; ENSG00000140090. ENST00000532405; ENSP00000431840; ENSG00000140090.
GeneID	123041.
KEGG	hsa:123041.
UCSC	uc001yai.3. human. uc010auj.3. human.
Organism-specific databases
CTD	123041.
GeneCards	GC14P092788.
HGNC	HGNC:10978. SLC24A4.
MIM	210750. phenotype. 609840. gene.
neXtProt	NX_Q8NFF2.
PharmGKB	PA35854.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0530.
HOVERGEN	HBG054881.
InParanoid	Q8NFF2.
KO	K13752.
OMA	SPFSVPE.
OrthoDB	EOG4W6NVW.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q8NFF2.
Bgee	Q8NFF2.
CleanEx	HS_SLC24A4.
Genevestigator	Q8NFF2.
GermOnline	ENSG00000140090. Homo sapiens.
Family and domain databases
InterPro	IPR004481. K/Na/Ca-exchanger. IPR004837. NaCa_Exmemb. [Graphical view]
PANTHER	PTHR10846. PTHR10846. 1 hit.
Pfam	PF01699. Na_Ca_ex. 2 hits. [Graphical view]
TIGRFAMs	TIGR00367. TIGR00367. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	123041.
NextBio	81061.
SOURCE	Search...

Entry information

Entry name

NCKX4_HUMAN

Accession

Primary (citable) accession number: Q8NFF2
Secondary accession number(s): B4DHE7 , B9ZVY2, Q8N8U6, Q8NCX1, Q8NFF0, Q8NFF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.