Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ankyrin repeat and protein kinase domain-containing protein 1

Gene

ANKK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51ATPPROSITE-ProRule annotation1
Active sitei145Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 36ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS10083-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and protein kinase domain-containing protein 1 (EC:2.7.11.1)
Alternative name(s):
Protein kinase PKK2
Sugen kinase 288
Short name:
SgK288
X-kinase
Gene namesi
Name:ANKK1
Synonyms:PKK2, SGK288
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:21027. ANKK1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi255239.
OpenTargetsiENSG00000170209.
PharmGKBiPA134872551.

Chemistry databases

ChEMBLiCHEMBL5547.
GuidetoPHARMACOLOGYi1932.

Polymorphism and mutation databases

BioMutaiANKK1.
DMDMi74762569.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000856201 – 765Ankyrin repeat and protein kinase domain-containing protein 1Add BLAST765

Proteomic databases

MaxQBiQ8NFD2.
PaxDbiQ8NFD2.
PeptideAtlasiQ8NFD2.
PRIDEiQ8NFD2.

PTM databases

iPTMnetiQ8NFD2.
PhosphoSitePlusiQ8NFD2.

Expressioni

Tissue specificityi

Highly expressed in brain and weakly expressed in placenta and spinal cord.2 Publications

Gene expression databases

BgeeiENSG00000170209.
CleanExiHS_ANKK1.
ExpressionAtlasiQ8NFD2. baseline and differential.

Organism-specific databases

HPAiHPA012813.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000306678.

Chemistry databases

BindingDBiQ8NFD2.

Structurei

3D structure databases

ProteinModelPortaliQ8NFD2.
SMRiQ8NFD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 289Protein kinasePROSITE-ProRule annotationAdd BLAST268
Repeati361 – 390ANK 1Add BLAST30
Repeati394 – 423ANK 2Add BLAST30
Repeati427 – 456ANK 3Add BLAST30
Repeati460 – 489ANK 4Add BLAST30
Repeati493 – 522ANK 5Add BLAST30
Repeati526 – 555ANK 6Add BLAST30
Repeati559 – 588ANK 7Add BLAST30
Repeati592 – 621ANK 8Add BLAST30
Repeati625 – 654ANK 9Add BLAST30
Repeati658 – 687ANK 10Add BLAST30
Repeati691 – 720ANK 11Add BLAST30
Repeati724 – 753ANK 12Add BLAST30

Sequence similaritiesi

Contains 12 ANK repeats.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IT5N. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00550000074536.
HOGENOMiHOG000294086.
HOVERGENiHBG061582.
InParanoidiQ8NFD2.
KOiK16289.
OMAiPCFLDIT.
OrthoDBiEOG091G00GN.
PhylomeDBiQ8NFD2.
TreeFamiTF106506.

Family and domain databases

Gene3Di1.25.40.20. 5 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF12796. Ank_2. 4 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 11 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 11 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NFD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADPTELRL GSLPVFTRDD FEGDWRLVAS GGFSQVFQAR HRRWRTEYAI
60 70 80 90 100
KCAPCLPPDA ASSDVNYLIE EAAKMKKIKF QHIVSIYGVC KQPLGIVMEF
110 120 130 140 150
MANGSLEKVL STHSLCWKLR FRIIHETSLA MNFLHSIKPP LLHLDLKPGN
160 170 180 190 200
ILLDSNMHVK ISDFGLSKWM EQSTRMQYIE RSALRGMLSY IPPEMFLESN
210 220 230 240 250
KAPGPKYDVY SFAIVIWELL TQKKPYSGFN MMMIIIRVAA GMRPSLQPVS
260 270 280 290 300
DQWPSEAQQM VDLMKRCWDQ DPKKRPCFLD ITIETDILLS LLQSRVAVPE
310 320 330 340 350
SKALARKVSC KLSLRQPGEV NEDISQELMD SDSGNYLKRA LQLSDRKNLV
360 370 380 390 400
PRDEELCIYE NKVTPLHFLV AQGSVEQVRL LLAHEVDVDC QTASGYTPLL
410 420 430 440 450
IAAQDQQPDL CALLLAHGAD ANRVDEDGWA PLHFAAQNGD DGTARLLLDH
460 470 480 490 500
GACVDAQERE GWTPLHLAAQ NNFENVARLL VSRQADPNLH EAEGKTPLHV
510 520 530 540 550
AAYFGHVSLV KLLTSQGAEL DAQQRNLRTP LHLAVERGKV RAIQHLLKSG
560 570 580 590 600
AVPDALDQSG YGPLHTAAAR GKYLICKMLL RYGASLELPT HQGWTPLHLA
610 620 630 640 650
AYKGHLEIIH LLAESHANMG ALGAVNWTPL HLAARHGEEA VVSALLQCGA
660 670 680 690 700
DPNAAEQSGW TPLHLAVQRS TFLSVINLLE HHANVHARNK VGWTPAHLAA
710 720 730 740 750
LKGNTAILKV LVEAGAQLDV QDGVSCTPLQ LALRSRKQGI MSFLEGKEPS
760
VATLGGSKPG AEMEI
Length:765
Mass (Da):84,632
Last modified:October 1, 2002 - v1
Checksum:i549F6161B2976BF5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0403594D → Y.1 PublicationCorresponds to variant rs35657708dbSNPEnsembl.1
Natural variantiVAR_040360122R → H.1 PublicationCorresponds to variant rs35877321dbSNPEnsembl.1
Natural variantiVAR_036784239A → T.1 PublicationCorresponds to variant rs7118900dbSNPEnsembl.1
Natural variantiVAR_040361276P → L.1 PublicationCorresponds to variant rs35488601dbSNPEnsembl.1
Natural variantiVAR_036785318G → R.1 PublicationCorresponds to variant rs11604671dbSNPEnsembl.1
Natural variantiVAR_040362347K → T in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040363366L → F.1 PublicationCorresponds to variant rs56339158dbSNPEnsembl.1
Natural variantiVAR_040364367H → Q.1 PublicationCorresponds to variant rs34298987dbSNPEnsembl.1
Natural variantiVAR_040365376E → K.1 PublicationCorresponds to variant rs56299709dbSNPEnsembl.1
Natural variantiVAR_040366426E → K.1 PublicationCorresponds to variant rs55699907dbSNPEnsembl.1
Natural variantiVAR_036786442G → R.1 PublicationCorresponds to variant rs4938016dbSNPEnsembl.1
Natural variantiVAR_040367451G → R.1 PublicationCorresponds to variant rs34983219dbSNPEnsembl.1
Natural variantiVAR_036787490H → R.1 PublicationCorresponds to variant rs2734849dbSNPEnsembl.1
Natural variantiVAR_040368595T → I.1 PublicationCorresponds to variant rs55787008dbSNPEnsembl.1
Natural variantiVAR_040369596P → L.1 PublicationCorresponds to variant rs7104979dbSNPEnsembl.1
Natural variantiVAR_040370653N → S.1 PublicationCorresponds to variant rs55849504dbSNPEnsembl.1
Natural variantiVAR_040371670S → G.1 PublicationCorresponds to variant rs56006094dbSNPEnsembl.1
Natural variantiVAR_025010713E → K.2 PublicationsCorresponds to variant rs1800497dbSNPEnsembl.1
Natural variantiVAR_040372717Q → L in a lung large cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040373736R → L in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040374764E → K in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ541797 mRNA. Translation: CAD62569.2.
AF487542 mRNA. Translation: AAQ09005.1.
AF525298 Genomic DNA. Translation: AAM91924.1.
CCDSiCCDS44734.1.
RefSeqiNP_848605.1. NM_178510.1.
UniGeneiHs.448473.

Genome annotation databases

EnsembliENST00000303941; ENSP00000306678; ENSG00000170209.
GeneIDi255239.
KEGGihsa:255239.
UCSCiuc001pny.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ541797 mRNA. Translation: CAD62569.2.
AF487542 mRNA. Translation: AAQ09005.1.
AF525298 Genomic DNA. Translation: AAM91924.1.
CCDSiCCDS44734.1.
RefSeqiNP_848605.1. NM_178510.1.
UniGeneiHs.448473.

3D structure databases

ProteinModelPortaliQ8NFD2.
SMRiQ8NFD2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000306678.

Chemistry databases

BindingDBiQ8NFD2.
ChEMBLiCHEMBL5547.
GuidetoPHARMACOLOGYi1932.

PTM databases

iPTMnetiQ8NFD2.
PhosphoSitePlusiQ8NFD2.

Polymorphism and mutation databases

BioMutaiANKK1.
DMDMi74762569.

Proteomic databases

MaxQBiQ8NFD2.
PaxDbiQ8NFD2.
PeptideAtlasiQ8NFD2.
PRIDEiQ8NFD2.

Protocols and materials databases

DNASUi255239.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303941; ENSP00000306678; ENSG00000170209.
GeneIDi255239.
KEGGihsa:255239.
UCSCiuc001pny.3. human.

Organism-specific databases

CTDi255239.
DisGeNETi255239.
GeneCardsiANKK1.
HGNCiHGNC:21027. ANKK1.
HPAiHPA012813.
MIMi608774. gene.
neXtProtiNX_Q8NFD2.
OpenTargetsiENSG00000170209.
PharmGKBiPA134872551.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IT5N. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00550000074536.
HOGENOMiHOG000294086.
HOVERGENiHBG061582.
InParanoidiQ8NFD2.
KOiK16289.
OMAiPCFLDIT.
OrthoDBiEOG091G00GN.
PhylomeDBiQ8NFD2.
TreeFamiTF106506.

Enzyme and pathway databases

BioCyciZFISH:HS10083-MONOMER.

Miscellaneous databases

GeneWikiiANKK1.
GenomeRNAii255239.
PROiQ8NFD2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170209.
CleanExiHS_ANKK1.
ExpressionAtlasiQ8NFD2. baseline and differential.

Family and domain databases

Gene3Di1.25.40.20. 5 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF12796. Ank_2. 4 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 11 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 11 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANKK1_HUMAN
AccessioniPrimary (citable) accession number: Q8NFD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.