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Protein

Biorientation of chromosomes in cell division protein 1-like 1

Gene

BOD1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBXO18/FBH1 and BLM (PubMed:26166705). Does not regulate spindle orientation (PubMed:26166705).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi2872 – 2884A.T hookAdd BLAST13

GO - Biological processi

  • cellular response to DNA damage stimulus Source: UniProtKB
  • DNA repair Source: UniProtKB-KW
  • replication fork processing Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Biorientation of chromosomes in cell division protein 1-like 1Curated
Gene namesi
Name:BOD1L1Imported
Synonyms:BOD1L, FAM44A, KIAA13271 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:31792. BOD1L1.

Subcellular locationi

  • Chromosome 1 Publication

  • Note: Localizes at replication forks: following DNA damage, localizes to damaged replication forks undergoing resection.1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi259282.
OpenTargetsiENSG00000038219.
PharmGKBiPA164716652.

Polymorphism and mutation databases

BioMutaiBOD1L1.
DMDMi158931124.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001870271 – 3051Biorientation of chromosomes in cell division protein 1-like 1Add BLAST3051

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei266PhosphoserineCombined sources1
Modified residuei473N6-acetyllysineCombined sources1
Modified residuei482PhosphoserineCombined sources1
Modified residuei484PhosphoserineCombined sources1
Modified residuei635PhosphoserineCombined sources1
Modified residuei659PhosphoserineCombined sources1
Modified residuei660PhosphothreonineCombined sources1
Modified residuei733PhosphothreonineCombined sources1
Modified residuei1077PhosphoserineCombined sources1
Modified residuei1145PhosphoserineCombined sources1
Modified residuei1318PhosphoserineCombined sources1
Modified residuei1354PhosphothreonineCombined sources1
Modified residuei1531PhosphoserineCombined sources1
Modified residuei1701PhosphoserineCombined sources1
Modified residuei1710PhosphoserineCombined sources1
Modified residuei2013PhosphoserineBy similarity1
Modified residuei2025PhosphoserineBy similarity1
Modified residuei2128PhosphoserineCombined sources1
Modified residuei2203PhosphoserineCombined sources1
Modified residuei2475PhosphoserineCombined sources1
Modified residuei2501PhosphoserineCombined sources1
Modified residuei2618PhosphoserineBy similarity1
Modified residuei2905PhosphoserineCombined sources1
Modified residuei2907PhosphoserineCombined sources1
Modified residuei2954PhosphoserineCombined sources1
Modified residuei2956PhosphothreonineCombined sources1
Modified residuei2958PhosphoserineCombined sources1
Modified residuei2964PhosphoserineCombined sources1
Modified residuei2973PhosphoserineCombined sources1
Cross-linki2981Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki2982Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei2986PhosphoserineCombined sources1
Modified residuei3019PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8NFC6.
MaxQBiQ8NFC6.
PaxDbiQ8NFC6.
PeptideAtlasiQ8NFC6.
PRIDEiQ8NFC6.

PTM databases

iPTMnetiQ8NFC6.
PhosphoSitePlusiQ8NFC6.

Expressioni

Gene expression databases

BgeeiENSG00000038219.
CleanExiHS_FAM44A.
ExpressionAtlasiQ8NFC6. baseline and differential.
GenevisibleiQ8NFC6. HS.

Organism-specific databases

HPAiHPA036943.
HPA037362.
HPA041290.

Interactioni

Protein-protein interaction databases

BioGridi129238. 32 interactors.
IntActiQ8NFC6. 24 interactors.
STRINGi9606.ENSP00000040738.

Structurei

3D structure databases

ProteinModelPortaliQ8NFC6.
SMRiQ8NFC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 36Pro-richAdd BLAST32
Compositional biasi315 – 1046Lys-richAdd BLAST732
Compositional biasi2760 – 2765Poly-Glu6
Compositional biasi2988 – 2997Poly-Glu10

Sequence similaritiesi

Belongs to the BOD1 family.Curated
Contains 1 A.T hook DNA-binding domain.Curated

Phylogenomic databases

eggNOGiENOG410IKUQ. Eukaryota.
ENOG4111M2Q. LUCA.
GeneTreeiENSGT00530000063517.
HOGENOMiHOG000112474.
InParanoidiQ8NFC6.
OMAiHVHAKSE.
OrthoDBiEOG091G0HQM.
PhylomeDBiQ8NFC6.
TreeFamiTF335808.

Family and domain databases

InterProiIPR026955. Bod1-like.
[Graphical view]
PANTHERiPTHR31532. PTHR31532. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8NFC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATNPQPQPP PPAPPPPPPQ PQPQPPPPPP GPGAGPGAGG AGGAGAGAGD
60 70 80 90 100
PQLVAMIVNH LKSQGLFDQF RRDCLADVDT KPAYQNLRQR VDNFVANHLA
110 120 130 140 150
THTWSPHLNK NQLRNNIRQQ VLKSGMLESG IDRIISQVVD PKINHTFRPQ
160 170 180 190 200
VEKAVHEFLA TLNHKEEGSG NTAPDDEKPD TSLITQGVPT PGPSANVAND
210 220 230 240 250
AMSILETITS LNQEASAARA STETSNAKTS ERASKKLPSQ PTTDTSTDKE
260 270 280 290 300
RTSEDMADKE KSTADSGGEG LETAPKSEEF SDLPCPVEEI KNYTKEHNNL
310 320 330 340 350
ILLNKDVQQE SSEQKNKSTD KGEKKPDSNE KGERKKEKKE KTEKKFDHSK
360 370 380 390 400
KSEDTQKVKD EKQAKEKEVE SLKLPSEKNS NKAKTVEGTK EDFSLIDSDV
410 420 430 440 450
DGLTDITVSS VHTSDLSSFE EDTEEEVVTS DSMEEGEITS DDEEKNKQNK
460 470 480 490 500
TKTQTSDSSE GKTKSVRHAY VHKPYLYSKY YSDSDDELTV EQRRQSIAKE
510 520 530 540 550
KEERLLRRQI NREKLEEKRK QKAEKTKSSK TKGQGRSSVD LEESSTKSLE
560 570 580 590 600
PKAARIKEVL KERKVLEKKV ALSKKRKKDS RNVEENSKKK QQYEEDSKET
610 620 630 640 650
LKTSEHCEKE KISSSKELKH VHAKSEPSKP ARRLSESLHV VDENKNESKL
660 670 680 690 700
EREHKRRTST PVIMEGVQEE TDTRDVKRQV ERSEICTEEP QKQKSTLKNE
710 720 730 740 750
KHLKKDDSET PHLKSLLKKE VKSSKEKPER EKTPSEDKLS VKHKYKGDCM
760 770 780 790 800
HKTGDETELH SSEKGLKVEE NIQKQSQQTK LSSDDKTERK SKHRNERKLS
810 820 830 840 850
VLGKDGKPVS EYIIKTDENV RKENNKKERR LSAEKTKAEH KSRRSSDSKI
860 870 880 890 900
QKDSLGSKQH GITLQRRSES YSEDKCDMDS TNMDSNLKPE EVVHKEKRRT
910 920 930 940 950
KSLLEEKLVL KSKSKTQGKQ VKVVETELQE GATKQATTPK PDKEKNTEEN
960 970 980 990 1000
DSEKQRKSKV EDKPFEETGV EPVLETASSS AHSTQKDSSH RAKLPLAKEK
1010 1020 1030 1040 1050
YKSDKDSTST RLERKLSDGH KSRSLKHSSK DIKKKDENKS DDKDGKEVDS
1060 1070 1080 1090 1100
SHEKARGNSS LMEKKLSRRL CENRRGSLSQ EMAKGEEKLA ANTLSTPSGS
1110 1120 1130 1140 1150
SLQRPKKSGD MTLIPEQEPM EIDSEPGVEN VFEVSKTQDN RNNNSQQDID
1160 1170 1180 1190 1200
SENMKQKTSA TVQKDELRTC TADSKATAPA YKPGRGTGVN SNSEKHADHR
1210 1220 1230 1240 1250
STLTKKMHIQ SAVSKMNPGE KEPIHRGTTE VNIDSETVHR MLLSAPSEND
1260 1270 1280 1290 1300
RVQKNLKNTA AEEHVAQGDA TLEHSTNLDS SPSLSSVTVV PLRESYDPDV
1310 1320 1330 1340 1350
IPLFDKRTVL EGSTASTSPA DHSALPNQSL TVRESEVLKT SDSKEGGEGF
1360 1370 1380 1390 1400
TVDTPAKASI TSKRHIPEAH QATLLDGKQG KVIMPLGSKL TGVIVENENI
1410 1420 1430 1440 1450
TKEGGLVDMA KKENDLNAEP NLKQTIKATV ENGKKDGIAV DHVVGLNTEK
1460 1470 1480 1490 1500
YAETVKLKHK RSPGKVKDIS IDVERRNENS EVDTSAGSGS APSVLHQRNG
1510 1520 1530 1540 1550
QTEDVATGPR RAEKTSVATS TEGKDKDVTL SPVKAGPATT TSSETRQSEV
1560 1570 1580 1590 1600
ALPCTSIEAD EGLIIGTHSR NNPLHVGAEA SECTVFAAAE EGGAVVTEGF
1610 1620 1630 1640 1650
AESETFLTST KEGESGECAV AESEDRAADL LAVHAVKIEA NVNSVVTEEK
1660 1670 1680 1690 1700
DDAVTSAGSE EKCDGSLSRD SEIVEGTITF ISEVESDGAV TSAGTEIRAG
1710 1720 1730 1740 1750
SISSEEVDGS QGNMMRMGPK KETEGTVTCT GAEGRSDNFV ICSVTGAGPR
1760 1770 1780 1790 1800
EERMVTGAGV VLGDNDAPPG TSASQEGDGS VNDGTEGESA VTSTGITEDG
1810 1820 1830 1840 1850
EGPASCTGSE DSSEGFAISS ESEENGESAM DSTVAKEGTN VPLVAAGPCD
1860 1870 1880 1890 1900
DEGIVTSTGA KEEDEEGEDV VTSTGRGNEI GHASTCTGLG EESEGVLICE
1910 1920 1930 1940 1950
SAEGDSQIGT VVEHVEAEAG AAIMNANENN VDSMSGTEKG SKDTDICSSA
1960 1970 1980 1990 2000
KGIVESSVTS AVSGKDEVTP VPGGCEGPMT SAASDQSDSQ LEKVEDTTIS
2010 2020 2030 2040 2050
TGLVGGSYDV LVSGEVPECE VAHTSPSEKE DEDIITSVEN EECDGLMATT
2060 2070 2080 2090 2100
ASGDITNQNS LAGGKNQGKV LIISTSTTND YTPQVSAITD VEGGLSDALR
2110 2120 2130 2140 2150
TEENMEGTRV TTEEFEAPMP SAVSGDDSQL TASRSEEKDE CAMISTSIGE
2160 2170 2180 2190 2200
EFELPISSAT TIKCAESLQP VAAAVEERAT GPVLISTADF EGPMPSAPPE
2210 2220 2230 2240 2250
AESPLASTSK EEKDECALIS TSIAEECEAS VSGVVVESEN ERAGTVMEEK
2260 2270 2280 2290 2300
DGSGIISTSS VEDCEGPVSS AVPQEEGDPS VTPAEEMGDT AMISTSTSEG
2310 2320 2330 2340 2350
CEAVMIGAVL QDEDRLTITR VEDLSDAAII STSTAECMPI SASIDRHEEN
2360 2370 2380 2390 2400
QLTADNPEGN GDLSATEVSK HKVPMPSLIA ENNCRCPGPV RGGKEPGPVL
2410 2420 2430 2440 2450
AVSTEEGHNG PSVHKPSAGQ GHPSAVCAEK EEKHGKECPE IGPFAGRGQK
2460 2470 2480 2490 2500
ESTLHLINAE EKNVLLNSLQ KEDKSPETGT AGGSSTASYS AGRGLEGNAN
2510 2520 2530 2540 2550
SPAHLRGPEQ TSGQTAKDPS VSIRYLAAVN TGAIKADDMP PVQGTVAEHS
2560 2570 2580 2590 2600
FLPAEQQGSE DNLKTSTTKC ITGQESKIAP SHTMIPPATY SVALLAPKCE
2610 2620 2630 2640 2650
QDLTIKNDYS GKWTDQASAE KTGDDNSTRK SFPEEGDIMV TVSSEENVCD
2660 2670 2680 2690 2700
IGNEESPLNV LGGLKLKANL KMEAYVPSEE EKNGEILAPP ESLCGGKPSG
2710 2720 2730 2740 2750
IAELQREPLL VNESLNVENS GFRTNEEIHS ESYNKGEISS GRKDNAEAIS
2760 2770 2780 2790 2800
GHSVEADPKE VEEEERHMPK RKRKQHYLSS EDEPDDNPDV LDSRIETAQR
2810 2820 2830 2840 2850
QCPETEPHDT KEENSRDLEE LPKTSSETNS TTSRVMEEKD EYSSSETTGE
2860 2870 2880 2890 2900
KPEQNDDDTI KSQEEDQPII IKRKRGRPRK YPVETTLKMK DDSKTDTGIV
2910 2920 2930 2940 2950
TVEQSPSSSK LKVMQTDESN KETANLQERS ISNDDGEEKI VTSVRRRGRK
2960 2970 2980 2990 3000
PKRSLTVSDD AESSEPERKR QKSVSDPVED KKEQESDEEE EEEEEDEPSG
3010 3020 3030 3040 3050
ATTRSTTRSE AQRSKTQLSP SIKRKREVSP PGARTRGQQR VEEAPVKKAK

R
Length:3,051
Mass (Da):330,466
Last modified:October 2, 2007 - v2
Checksum:i44AD19BDDFDCE560
GO

Sequence cautioni

The sequence AAH16987 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15299 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence CAB70705 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti337E → K in AAH65546 (PubMed:15489334).Curated1
Sequence conflicti337E → K in AAH87835 (PubMed:15489334).Curated1
Sequence conflicti498 – 502AKEKE → GILWF in AAM94279 (Ref. 2) Curated5
Sequence conflicti1417N → S in BAB15299 (PubMed:14702039).Curated1
Sequence conflicti1438I → V in BAB15299 (PubMed:14702039).Curated1
Sequence conflicti1740V → M in BAB15299 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036124246S → I in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_035220429T → M.Corresponds to variant rs2035820dbSNPEnsembl.1
Natural variantiVAR_035221650L → I.Corresponds to variant rs1971278dbSNPEnsembl.1
Natural variantiVAR_0352221369A → G.Corresponds to variant rs17745712dbSNPEnsembl.1
Natural variantiVAR_0352231448T → A.Corresponds to variant rs17745676dbSNPEnsembl.1
Natural variantiVAR_0352241515T → A.Corresponds to variant rs16888885dbSNPEnsembl.1
Natural variantiVAR_0352251645V → I.Corresponds to variant rs17807493dbSNPEnsembl.1
Natural variantiVAR_0352262361G → S.Corresponds to variant rs3822227dbSNPEnsembl.1
Natural variantiVAR_0352272396P → L.1 PublicationCorresponds to variant rs3733557dbSNPEnsembl.1
Natural variantiVAR_0611662944V → M.Corresponds to variant rs28538279dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006445 Genomic DNA. No translation available.
AF528529 mRNA. Translation: AAM94279.1.
BC016987 mRNA. Translation: AAH16987.1. Different initiation.
BC065546 mRNA. Translation: AAH65546.1.
BC087835 mRNA. Translation: AAH87835.1.
AK025965 mRNA. Translation: BAB15299.1. Different termination.
AB037748 mRNA. Translation: BAA92565.2.
AL137350 mRNA. Translation: CAB70705.1. Different termination.
CCDSiCCDS3411.2.
PIRiT46424.
RefSeqiNP_683692.2. NM_148894.2.
UniGeneiHs.744935.

Genome annotation databases

EnsembliENST00000040738; ENSP00000040738; ENSG00000038219.
GeneIDi259282.
KEGGihsa:259282.
UCSCiuc003gmz.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006445 Genomic DNA. No translation available.
AF528529 mRNA. Translation: AAM94279.1.
BC016987 mRNA. Translation: AAH16987.1. Different initiation.
BC065546 mRNA. Translation: AAH65546.1.
BC087835 mRNA. Translation: AAH87835.1.
AK025965 mRNA. Translation: BAB15299.1. Different termination.
AB037748 mRNA. Translation: BAA92565.2.
AL137350 mRNA. Translation: CAB70705.1. Different termination.
CCDSiCCDS3411.2.
PIRiT46424.
RefSeqiNP_683692.2. NM_148894.2.
UniGeneiHs.744935.

3D structure databases

ProteinModelPortaliQ8NFC6.
SMRiQ8NFC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129238. 32 interactors.
IntActiQ8NFC6. 24 interactors.
STRINGi9606.ENSP00000040738.

PTM databases

iPTMnetiQ8NFC6.
PhosphoSitePlusiQ8NFC6.

Polymorphism and mutation databases

BioMutaiBOD1L1.
DMDMi158931124.

Proteomic databases

EPDiQ8NFC6.
MaxQBiQ8NFC6.
PaxDbiQ8NFC6.
PeptideAtlasiQ8NFC6.
PRIDEiQ8NFC6.

Protocols and materials databases

DNASUi259282.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000040738; ENSP00000040738; ENSG00000038219.
GeneIDi259282.
KEGGihsa:259282.
UCSCiuc003gmz.2. human.

Organism-specific databases

CTDi259282.
DisGeNETi259282.
GeneCardsiBOD1L1.
H-InvDBHIX0004103.
HGNCiHGNC:31792. BOD1L1.
HPAiHPA036943.
HPA037362.
HPA041290.
MIMi616746. gene.
neXtProtiNX_Q8NFC6.
OpenTargetsiENSG00000038219.
PharmGKBiPA164716652.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKUQ. Eukaryota.
ENOG4111M2Q. LUCA.
GeneTreeiENSGT00530000063517.
HOGENOMiHOG000112474.
InParanoidiQ8NFC6.
OMAiHVHAKSE.
OrthoDBiEOG091G0HQM.
PhylomeDBiQ8NFC6.
TreeFamiTF335808.

Miscellaneous databases

ChiTaRSiBOD1L1. human.
GenomeRNAii259282.
PROiQ8NFC6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000038219.
CleanExiHS_FAM44A.
ExpressionAtlasiQ8NFC6. baseline and differential.
GenevisibleiQ8NFC6. HS.

Family and domain databases

InterProiIPR026955. Bod1-like.
[Graphical view]
PANTHERiPTHR31532. PTHR31532. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiBD1L1_HUMAN
AccessioniPrimary (citable) accession number: Q8NFC6
Secondary accession number(s): Q6P0M8
, Q96AL1, Q9H6G0, Q9NTD6, Q9P2L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 2, 2007
Last modified: November 30, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.