Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 185A

Gene

TMEM185A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 185A
Alternative name(s):
Protein FAM11A
Gene namesi
Name:TMEM185A
Synonyms:CXorf13, FAM11A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:17125. TMEM185A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence analysisAdd
BLAST
Transmembranei41 – 6121HelicalSequence analysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence analysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence analysisAdd
BLAST
Transmembranei177 – 19721HelicalSequence analysisAdd
BLAST
Transmembranei211 – 23121HelicalSequence analysisAdd
BLAST
Transmembranei240 – 26021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

MalaCardsiTMEM185A.
Orphaneti100974. FRAXF syndrome.
PharmGKBiPA27062.

Polymorphism and mutation databases

BioMutaiTMEM185A.
DMDMi550544296.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Transmembrane protein 185APRO_0000188007Add
BLAST

Proteomic databases

PaxDbiQ8NFB2.
PRIDEiQ8NFB2.

PTM databases

iPTMnetiQ8NFB2.
PhosphoSiteiQ8NFB2.

Expressioni

Gene expression databases

BgeeiQ8NFB2.
CleanExiHS_TMEM185A.
ExpressionAtlasiQ8NFB2. baseline and differential.
GenevisibleiQ8NFB2. HS.

Organism-specific databases

HPAiHPA048295.

Interactioni

Subunit structurei

Interacts with MAP1B.1 Publication

Protein-protein interaction databases

BioGridi124133. 59 interactions.
STRINGi9606.ENSP00000359449.

Structurei

3D structure databases

ProteinModelPortaliQ8NFB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni298 – 35053Mediates interaction with MAP1BAdd
BLAST

Sequence similaritiesi

Belongs to the TMEM185 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3879. Eukaryota.
ENOG410XURH. LUCA.
HOGENOMiHOG000231372.
HOVERGENiHBG051528.
InParanoidiQ8NFB2.
PhylomeDBiQ8NFB2.
TreeFamiTF313829.

Family and domain databases

InterProiIPR019396. TM_Fragile-X-F-assoc.
[Graphical view]
PfamiPF10269. Tmemb_185A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NFB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLRGLFQDF NPSKFLIYAC LLLFSVLLAL RLDGIIQWSY WAVFAPIWLW
60 70 80 90 100
KLMVIVGASV GTGVWARNPQ YRAEGETCVE FKAMLIAVGI HLLLLMFEVL
110 120 130 140 150
VCDRIERGSH FWLLVFMPLF FVSPVSVAAC VWGFRHDRSL ELEILCSVNI
160 170 180 190 200
LQFIFIALRL DKIIHWPWLV VCVPLWILMS FLCLVVLYYI VWSVLFLRSM
210 220 230 240 250
DVIAEQRRTH ITMALSWMTI VVPLLTFEIL LVHKLDGHNA FSSIPIFVPL
260 270 280 290 300
WLSLITLMAT TFGQKGGNHW WFGIRKDFCQ FLLEIFPFLR EYGNISYDLH
310 320 330 340 350
HEDNEETEET PVPEPPKIAP MFRKKARVVI TQSPGKYVLP PPKLNIEMPD
Length:350
Mass (Da):40,631
Last modified:October 16, 2013 - v2
Checksum:i43F737AF9EC6276F
GO

Sequence cautioni

The sequence AAH13793.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti179 – 1791M → V.
Corresponds to variant rs396058 [ dbSNP | Ensembl ].
VAR_033922
Natural varianti243 – 2431S → C.5 Publications
Corresponds to variant rs609828 [ dbSNP | Ensembl ].
VAR_033923

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF530473 mRNA. Translation: AAM94598.1.
AK096308 mRNA. Translation: BAG53255.1.
AK097391 mRNA. Translation: BAC05031.1.
AC231844 Genomic DNA. No translation available.
AC233288 Genomic DNA. No translation available.
CH471169 Genomic DNA. Translation: EAW99368.1.
BC013793 mRNA. Translation: AAH13793.1. Different initiation.
BC103821 mRNA. Translation: AAI03822.1.
BC103822 mRNA. Translation: AAI03823.1.
AF353675 mRNA. Translation: AAK39521.1.
CCDSiCCDS14689.1.
RefSeqiNP_001167563.1. NM_001174092.2.
NP_001269231.1. NM_001282302.1.
NP_115897.1. NM_032508.3.
UniGeneiHs.522172.

Genome annotation databases

EnsembliENST00000600449; ENSP00000471932; ENSG00000269556.
GeneIDi84548.
KEGGihsa:84548.
UCSCiuc033ezr.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF530473 mRNA. Translation: AAM94598.1.
AK096308 mRNA. Translation: BAG53255.1.
AK097391 mRNA. Translation: BAC05031.1.
AC231844 Genomic DNA. No translation available.
AC233288 Genomic DNA. No translation available.
CH471169 Genomic DNA. Translation: EAW99368.1.
BC013793 mRNA. Translation: AAH13793.1. Different initiation.
BC103821 mRNA. Translation: AAI03822.1.
BC103822 mRNA. Translation: AAI03823.1.
AF353675 mRNA. Translation: AAK39521.1.
CCDSiCCDS14689.1.
RefSeqiNP_001167563.1. NM_001174092.2.
NP_001269231.1. NM_001282302.1.
NP_115897.1. NM_032508.3.
UniGeneiHs.522172.

3D structure databases

ProteinModelPortaliQ8NFB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124133. 59 interactions.
STRINGi9606.ENSP00000359449.

PTM databases

iPTMnetiQ8NFB2.
PhosphoSiteiQ8NFB2.

Polymorphism and mutation databases

BioMutaiTMEM185A.
DMDMi550544296.

Proteomic databases

PaxDbiQ8NFB2.
PRIDEiQ8NFB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000600449; ENSP00000471932; ENSG00000269556.
GeneIDi84548.
KEGGihsa:84548.
UCSCiuc033ezr.1. human.

Organism-specific databases

CTDi84548.
GeneCardsiTMEM185A.
H-InvDBHIX0176539.
HGNCiHGNC:17125. TMEM185A.
HPAiHPA048295.
MalaCardsiTMEM185A.
MIMi300031. gene.
neXtProtiNX_Q8NFB2.
Orphaneti100974. FRAXF syndrome.
PharmGKBiPA27062.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3879. Eukaryota.
ENOG410XURH. LUCA.
HOGENOMiHOG000231372.
HOVERGENiHBG051528.
InParanoidiQ8NFB2.
PhylomeDBiQ8NFB2.
TreeFamiTF313829.

Miscellaneous databases

ChiTaRSiTMEM185A. human.
GenomeRNAii84548.
PROiQ8NFB2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NFB2.
CleanExiHS_TMEM185A.
ExpressionAtlasiQ8NFB2. baseline and differential.
GenevisibleiQ8NFB2. HS.

Family and domain databases

InterProiIPR019396. TM_Fragile-X-F-assoc.
[Graphical view]
PfamiPF10269. Tmemb_185A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene, FAM11A, associated with the FRAXF CpG island is transcriptionally silent in FRAXF full mutation."
    Shaw M.A., Chiurazzi P., Romain D.R., Neri G., Gecz J.
    Eur. J. Hum. Genet. 10:767-772(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT CYS-243.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT CYS-243.
    Tissue: Testis.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT CYS-243.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT CYS-243.
    Tissue: Brain.
  6. "Novel iris cDNA from Xq28."
    Wistow G.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 148-350, VARIANT CYS-243.
    Tissue: Iris.
  7. "Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor."
    Maurer M.H., Gruenewald S., Gassler N., Rossner M., Propst F., Wuerz R., Weber D., Kuner T., Kuschinsky W., Schneider A.
    J. Neurochem. 91:1007-1017(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MAP1B.

Entry informationi

Entry nameiT185A_HUMAN
AccessioniPrimary (citable) accession number: Q8NFB2
Secondary accession number(s): B3KTZ3
, Q3SYH1, Q96CW3, Q96KE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 16, 2013
Last modified: June 8, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.