Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 185A

Gene

TMEM185A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155984-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 185A
Alternative name(s):
Protein FAM11A
Gene namesi
Name:TMEM185A
Synonyms:CXorf13, FAM11A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:17125. TMEM185A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84548.
MalaCardsiTMEM185A.
Orphaneti100974. FRAXF syndrome.
PharmGKBiPA27062.

Polymorphism and mutation databases

BioMutaiTMEM185A.
DMDMi550544296.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001880071 – 350Transmembrane protein 185AAdd BLAST350

Proteomic databases

MaxQBiQ8NFB2.
PaxDbiQ8NFB2.
PeptideAtlasiQ8NFB2.
PRIDEiQ8NFB2.

PTM databases

iPTMnetiQ8NFB2.
PhosphoSitePlusiQ8NFB2.

Expressioni

Gene expression databases

BgeeiENSG00000155984.
CleanExiHS_TMEM185A.
ExpressionAtlasiQ8NFB2. baseline and differential.
GenevisibleiQ8NFB2. HS.

Organism-specific databases

HPAiHPA048295.

Interactioni

Subunit structurei

Interacts with MAP1B.1 Publication

Protein-protein interaction databases

BioGridi124133. 59 interactors.
STRINGi9606.ENSP00000359449.

Structurei

3D structure databases

ProteinModelPortaliQ8NFB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni298 – 350Mediates interaction with MAP1B1 PublicationAdd BLAST53

Sequence similaritiesi

Belongs to the TMEM185 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3879. Eukaryota.
ENOG410XURH. LUCA.
HOGENOMiHOG000231372.
HOVERGENiHBG051528.
InParanoidiQ8NFB2.
OrthoDBiEOG091G0CR4.
PhylomeDBiQ8NFB2.
TreeFamiTF313829.

Family and domain databases

InterProiIPR019396. TM_Fragile-X-F-assoc.
[Graphical view]
PfamiPF10269. Tmemb_185A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NFB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLRGLFQDF NPSKFLIYAC LLLFSVLLAL RLDGIIQWSY WAVFAPIWLW
60 70 80 90 100
KLMVIVGASV GTGVWARNPQ YRAEGETCVE FKAMLIAVGI HLLLLMFEVL
110 120 130 140 150
VCDRIERGSH FWLLVFMPLF FVSPVSVAAC VWGFRHDRSL ELEILCSVNI
160 170 180 190 200
LQFIFIALRL DKIIHWPWLV VCVPLWILMS FLCLVVLYYI VWSVLFLRSM
210 220 230 240 250
DVIAEQRRTH ITMALSWMTI VVPLLTFEIL LVHKLDGHNA FSSIPIFVPL
260 270 280 290 300
WLSLITLMAT TFGQKGGNHW WFGIRKDFCQ FLLEIFPFLR EYGNISYDLH
310 320 330 340 350
HEDNEETEET PVPEPPKIAP MFRKKARVVI TQSPGKYVLP PPKLNIEMPD
Length:350
Mass (Da):40,631
Last modified:October 16, 2013 - v2
Checksum:i43F737AF9EC6276F
GO

Sequence cautioni

The sequence AAH13793 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033922179M → V.Corresponds to variant rs396058dbSNPEnsembl.1
Natural variantiVAR_033923243S → C.5 PublicationsCorresponds to variant rs609828dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF530473 mRNA. Translation: AAM94598.1.
AK096308 mRNA. Translation: BAG53255.1.
AK097391 mRNA. Translation: BAC05031.1.
AC231844 Genomic DNA. No translation available.
AC233288 Genomic DNA. No translation available.
CH471169 Genomic DNA. Translation: EAW99368.1.
BC013793 mRNA. Translation: AAH13793.1. Different initiation.
BC103821 mRNA. Translation: AAI03822.1.
BC103822 mRNA. Translation: AAI03823.1.
AF353675 mRNA. Translation: AAK39521.1.
CCDSiCCDS14689.1.
RefSeqiNP_001167563.1. NM_001174092.2.
NP_001269231.1. NM_001282302.1.
NP_115897.1. NM_032508.3.
UniGeneiHs.522172.

Genome annotation databases

EnsembliENST00000600449; ENSP00000471932; ENSG00000269556.
GeneIDi84548.
KEGGihsa:84548.
UCSCiuc033ezr.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF530473 mRNA. Translation: AAM94598.1.
AK096308 mRNA. Translation: BAG53255.1.
AK097391 mRNA. Translation: BAC05031.1.
AC231844 Genomic DNA. No translation available.
AC233288 Genomic DNA. No translation available.
CH471169 Genomic DNA. Translation: EAW99368.1.
BC013793 mRNA. Translation: AAH13793.1. Different initiation.
BC103821 mRNA. Translation: AAI03822.1.
BC103822 mRNA. Translation: AAI03823.1.
AF353675 mRNA. Translation: AAK39521.1.
CCDSiCCDS14689.1.
RefSeqiNP_001167563.1. NM_001174092.2.
NP_001269231.1. NM_001282302.1.
NP_115897.1. NM_032508.3.
UniGeneiHs.522172.

3D structure databases

ProteinModelPortaliQ8NFB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124133. 59 interactors.
STRINGi9606.ENSP00000359449.

PTM databases

iPTMnetiQ8NFB2.
PhosphoSitePlusiQ8NFB2.

Polymorphism and mutation databases

BioMutaiTMEM185A.
DMDMi550544296.

Proteomic databases

MaxQBiQ8NFB2.
PaxDbiQ8NFB2.
PeptideAtlasiQ8NFB2.
PRIDEiQ8NFB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000600449; ENSP00000471932; ENSG00000269556.
GeneIDi84548.
KEGGihsa:84548.
UCSCiuc033ezr.1. human.

Organism-specific databases

CTDi84548.
DisGeNETi84548.
GeneCardsiTMEM185A.
H-InvDBHIX0176539.
HGNCiHGNC:17125. TMEM185A.
HPAiHPA048295.
MalaCardsiTMEM185A.
MIMi300031. gene.
neXtProtiNX_Q8NFB2.
Orphaneti100974. FRAXF syndrome.
PharmGKBiPA27062.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3879. Eukaryota.
ENOG410XURH. LUCA.
HOGENOMiHOG000231372.
HOVERGENiHBG051528.
InParanoidiQ8NFB2.
OrthoDBiEOG091G0CR4.
PhylomeDBiQ8NFB2.
TreeFamiTF313829.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155984-MONOMER.

Miscellaneous databases

ChiTaRSiTMEM185A. human.
GenomeRNAii84548.
PROiQ8NFB2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155984.
CleanExiHS_TMEM185A.
ExpressionAtlasiQ8NFB2. baseline and differential.
GenevisibleiQ8NFB2. HS.

Family and domain databases

InterProiIPR019396. TM_Fragile-X-F-assoc.
[Graphical view]
PfamiPF10269. Tmemb_185A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT185A_HUMAN
AccessioniPrimary (citable) accession number: Q8NFB2
Secondary accession number(s): B3KTZ3
, Q3SYH1, Q96CW3, Q96KE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 16, 2013
Last modified: November 2, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.