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Q8NF99

- ZN397_HUMAN

UniProt

Q8NF99 - ZN397_HUMAN

Protein

Zinc finger protein 397

Gene

ZNF397

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (31 Oct 2003)
      Previous versions | rss
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    Functioni

    Isoform 3 acts as a DNA-dependent transcriptional repressor.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri285 – 30723C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri313 – 33523C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri341 – 36323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri369 – 39123C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri397 – 41923C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri425 – 44723C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri453 – 47523C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri481 – 50323C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri509 – 53123C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 397
    Alternative name(s):
    Zinc finger and SCAN domain-containing protein 15
    Zinc finger protein 47
    Gene namesi
    Name:ZNF397
    Synonyms:ZNF47, ZSCAN15
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:18818. ZNF397.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38694.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 534534Zinc finger protein 397PRO_0000047564Add
    BLAST

    Proteomic databases

    MaxQBiQ8NF99.
    PaxDbiQ8NF99.
    PRIDEiQ8NF99.

    PTM databases

    PhosphoSiteiQ8NF99.

    Expressioni

    Tissue specificityi

    Expressed strongly in testis, moderately in skeletal muscle, pancreas and prostate, and weakly in heart, placenta, liver, kidney, spleen, thymus and small intestine.1 Publication

    Gene expression databases

    ArrayExpressiQ8NF99.
    BgeeiQ8NF99.
    CleanExiHS_ZNF397.
    GenevestigatoriQ8NF99.

    Organism-specific databases

    HPAiHPA026087.

    Interactioni

    Subunit structurei

    Isoforms 1 and 3 can both homo- and hetero-associate. Homo-association of isoform 1 is dependent on the presence of the SCAN domain.1 Publication

    Protein-protein interaction databases

    BioGridi124033. 3 interactions.
    STRINGi9606.ENSP00000331577.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NF99.
    SMRiQ8NF99. Positions 47-134, 258-532.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini50 – 13283SCAN boxPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SCAN box domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri285 – 30723C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri313 – 33523C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri341 – 36323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri369 – 39123C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri397 – 41923C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri425 – 44723C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri453 – 47523C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri481 – 50323C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri509 – 53123C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234619.
    HOVERGENiHBG018163.
    InParanoidiQ8NF99.
    KOiK09230.
    OMAiIPSIEIC.
    PhylomeDBiQ8NF99.
    TreeFamiTF338304.

    Family and domain databases

    Gene3Di3.30.160.60. 9 hits.
    InterProiIPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF02023. SCAN. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 9 hits.
    [Graphical view]
    SUPFAMiSSF47353. SSF47353. 1 hit.
    PROSITEiPS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 9 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NF99-1) [UniParc]FASTAAdd to Basket

    Also known as: ZNF397-fu

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAVESGVIST LIPQDPPEQE LILVKVEDNF SWDEKFKQNG STQSCQELFR    50
    QQFRKFCYQE TPGPREALSR LQELCYQWLM PELHTKEQIL ELLVLEQFLS 100
    ILPEELQIWV QQHNPESGEE AVTLLEDLER EFDDPGQQVP ASPQGPAVPW 150
    KDLTCLRASQ ESTDIHLQPL KTQLKSWKPC LSPKSDCENS ETATKEGISE 200
    EKSQGLPQEP SFRGISEHES NLVWKQGSAT GEKLRSPSQG GSFSQVIFTN 250
    KSLGKRDLYD EAERCLILTT DSIMCQKVPP EERPYRCDVC GHSFKQHSSL 300
    TQHQRIHTGE KPYKCNQCGK AFSLRSYLII HQRIHSGEKA YECSECGKAF 350
    NQSSALIRHR KIHTGEKACK CNECGKAFSQ SSYLIIHQRI HTGEKPYECN 400
    ECGKTFSQSS KLIRHQRIHT GERPYECNEC GKAFRQSSEL ITHQRIHSGE 450
    KPYECSECGK AFSLSSNLIR HQRIHSGEEP YQCNECGKTF KRSSALVQHQ 500
    RIHSGDEAYI CNECGKAFRH RSVLMRHQRV HTIK 534
    Length:534
    Mass (Da):61,139
    Last modified:October 31, 2003 - v2
    Checksum:iE990609DABABDE2A
    GO
    Isoform 2 (identifier: Q8NF99-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         216-275: SEHESNLVWK...LILTTDSIMC → KLSRPPKASS...SKNVNRKYFS
         276-534: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:275
    Mass (Da):31,052
    Checksum:iB745896D4FDD142E
    GO
    Isoform 3 (identifier: Q8NF99-3) [UniParc]FASTAAdd to Basket

    Also known as: Truncated, ZNF397-nf

    The sequence of this isoform differs from the canonical sequence as follows:
         186-207: DCENSETATKEGISEEKSQGLP → GEEWEIIWKLLTLRPLFLRMQN
         208-534: Missing.

    Show »
    Length:207
    Mass (Da):24,141
    Checksum:iBC397F169EF9962E
    GO

    Sequence cautioni

    Isoform 3 : The sequence AAN65175.1 differs from that shown. Reason: Frameshift at position 194.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei186 – 20722DCENS…SQGLP → GEEWEIIWKLLTLRPLFLRM QN in isoform 3. 1 PublicationVSP_042491Add
    BLAST
    Alternative sequencei208 – 534327Missing in isoform 3. 1 PublicationVSP_042492Add
    BLAST
    Alternative sequencei216 – 27560SEHES…DSIMC → KLSRPPKASSAIRWECVSPG SFPGDIIAAEATHSTISCFA INTLPATILPSKNVNRKYFS in isoform 2. 1 PublicationVSP_006924Add
    BLAST
    Alternative sequencei276 – 534259Missing in isoform 2. 1 PublicationVSP_006925Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF533250 mRNA. Translation: AAM95991.2.
    AY157641 mRNA. Translation: AAN65175.1. Frameshift.
    BC006172 mRNA. Translation: AAH06172.1.
    CCDSiCCDS32814.1. [Q8NF99-2]
    CCDS45852.1. [Q8NF99-1]
    RefSeqiNP_001128650.1. NM_001135178.2. [Q8NF99-1]
    NP_115723.1. NM_032347.2. [Q8NF99-2]
    UniGeneiHs.591061.

    Genome annotation databases

    EnsembliENST00000261333; ENSP00000261333; ENSG00000186812. [Q8NF99-2]
    ENST00000330501; ENSP00000331577; ENSG00000186812. [Q8NF99-1]
    ENST00000585800; ENSP00000466760; ENSG00000186812. [Q8NF99-3]
    ENST00000591206; ENSP00000466317; ENSG00000186812. [Q8NF99-3]
    GeneIDi84307.
    KEGGihsa:84307.
    UCSCiuc002kyi.3. human. [Q8NF99-3]
    uc002kyj.3. human. [Q8NF99-2]
    uc010dmp.3. human. [Q8NF99-1]

    Polymorphism databases

    DMDMi38258943.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF533250 mRNA. Translation: AAM95991.2 .
    AY157641 mRNA. Translation: AAN65175.1 . Frameshift.
    BC006172 mRNA. Translation: AAH06172.1 .
    CCDSi CCDS32814.1. [Q8NF99-2 ]
    CCDS45852.1. [Q8NF99-1 ]
    RefSeqi NP_001128650.1. NM_001135178.2. [Q8NF99-1 ]
    NP_115723.1. NM_032347.2. [Q8NF99-2 ]
    UniGenei Hs.591061.

    3D structure databases

    ProteinModelPortali Q8NF99.
    SMRi Q8NF99. Positions 47-134, 258-532.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124033. 3 interactions.
    STRINGi 9606.ENSP00000331577.

    PTM databases

    PhosphoSitei Q8NF99.

    Polymorphism databases

    DMDMi 38258943.

    Proteomic databases

    MaxQBi Q8NF99.
    PaxDbi Q8NF99.
    PRIDEi Q8NF99.

    Protocols and materials databases

    DNASUi 84307.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261333 ; ENSP00000261333 ; ENSG00000186812 . [Q8NF99-2 ]
    ENST00000330501 ; ENSP00000331577 ; ENSG00000186812 . [Q8NF99-1 ]
    ENST00000585800 ; ENSP00000466760 ; ENSG00000186812 . [Q8NF99-3 ]
    ENST00000591206 ; ENSP00000466317 ; ENSG00000186812 . [Q8NF99-3 ]
    GeneIDi 84307.
    KEGGi hsa:84307.
    UCSCi uc002kyi.3. human. [Q8NF99-3 ]
    uc002kyj.3. human. [Q8NF99-2 ]
    uc010dmp.3. human. [Q8NF99-1 ]

    Organism-specific databases

    CTDi 84307.
    GeneCardsi GC18P032820.
    HGNCi HGNC:18818. ZNF397.
    HPAi HPA026087.
    MIMi 609601. gene.
    neXtProti NX_Q8NF99.
    PharmGKBi PA38694.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234619.
    HOVERGENi HBG018163.
    InParanoidi Q8NF99.
    KOi K09230.
    OMAi IPSIEIC.
    PhylomeDBi Q8NF99.
    TreeFami TF338304.

    Miscellaneous databases

    ChiTaRSi ZNF397. human.
    GenomeRNAii 84307.
    NextBioi 73992.
    PROi Q8NF99.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NF99.
    Bgeei Q8NF99.
    CleanExi HS_ZNF397.
    Genevestigatori Q8NF99.

    Family and domain databases

    Gene3Di 3.30.160.60. 9 hits.
    InterProi IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF02023. SCAN. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 9 hits.
    [Graphical view ]
    SUPFAMi SSF47353. SSF47353. 1 hit.
    PROSITEi PS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 9 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of two novel human SCAN domain-containing zinc finger genes ZNF396 and ZNF397."
      Wu Y., Yu L., Bi G., Luo K., Zhou G., Zhao S.
      Gene 310:193-201(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Hepatoma.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Uterus.

    Entry informationi

    Entry nameiZN397_HUMAN
    AccessioniPrimary (citable) accession number: Q8NF99
    Secondary accession number(s): Q9BRM2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 28, 2003
    Last sequence update: October 31, 2003
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3