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Q8NF99

- ZN397_HUMAN

UniProt

Q8NF99 - ZN397_HUMAN

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Protein

Zinc finger protein 397

Gene
ZNF397, ZNF47, ZSCAN15
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Isoform 3 acts as a DNA-dependent transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri285 – 30723C2H2-type 1Add
BLAST
Zinc fingeri313 – 33523C2H2-type 2Add
BLAST
Zinc fingeri341 – 36323C2H2-type 3Add
BLAST
Zinc fingeri369 – 39123C2H2-type 4Add
BLAST
Zinc fingeri397 – 41923C2H2-type 5Add
BLAST
Zinc fingeri425 – 44723C2H2-type 6Add
BLAST
Zinc fingeri453 – 47523C2H2-type 7Add
BLAST
Zinc fingeri481 – 50323C2H2-type 8Add
BLAST
Zinc fingeri509 – 53123C2H2-type 9Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 397
Alternative name(s):
Zinc finger and SCAN domain-containing protein 15
Zinc finger protein 47
Gene namesi
Name:ZNF397
Synonyms:ZNF47, ZSCAN15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:18818. ZNF397.

Subcellular locationi

Isoform 1 : Nucleus 1 Publication
Isoform 3 : Nucleus. Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38694.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534Zinc finger protein 397PRO_0000047564Add
BLAST

Proteomic databases

MaxQBiQ8NF99.
PaxDbiQ8NF99.
PRIDEiQ8NF99.

PTM databases

PhosphoSiteiQ8NF99.

Expressioni

Tissue specificityi

Expressed strongly in testis, moderately in skeletal muscle, pancreas and prostate, and weakly in heart, placenta, liver, kidney, spleen, thymus and small intestine.1 Publication

Gene expression databases

ArrayExpressiQ8NF99.
BgeeiQ8NF99.
CleanExiHS_ZNF397.
GenevestigatoriQ8NF99.

Organism-specific databases

HPAiHPA026087.

Interactioni

Subunit structurei

Isoforms 1 and 3 can both homo- and hetero-associate. Homo-association of isoform 1 is dependent on the presence of the SCAN domain.1 Publication

Protein-protein interaction databases

BioGridi124033. 3 interactions.
STRINGi9606.ENSP00000331577.

Structurei

3D structure databases

ProteinModelPortaliQ8NF99.
SMRiQ8NF99. Positions 47-134, 258-532.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 13283SCAN boxAdd
BLAST

Sequence similaritiesi

Contains 1 SCAN box domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ8NF99.
KOiK09230.
OMAiIPSIEIC.
PhylomeDBiQ8NF99.
TreeFamiTF338304.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NF99-1) [UniParc]FASTAAdd to Basket

Also known as: ZNF397-fu

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAVESGVIST LIPQDPPEQE LILVKVEDNF SWDEKFKQNG STQSCQELFR    50
QQFRKFCYQE TPGPREALSR LQELCYQWLM PELHTKEQIL ELLVLEQFLS 100
ILPEELQIWV QQHNPESGEE AVTLLEDLER EFDDPGQQVP ASPQGPAVPW 150
KDLTCLRASQ ESTDIHLQPL KTQLKSWKPC LSPKSDCENS ETATKEGISE 200
EKSQGLPQEP SFRGISEHES NLVWKQGSAT GEKLRSPSQG GSFSQVIFTN 250
KSLGKRDLYD EAERCLILTT DSIMCQKVPP EERPYRCDVC GHSFKQHSSL 300
TQHQRIHTGE KPYKCNQCGK AFSLRSYLII HQRIHSGEKA YECSECGKAF 350
NQSSALIRHR KIHTGEKACK CNECGKAFSQ SSYLIIHQRI HTGEKPYECN 400
ECGKTFSQSS KLIRHQRIHT GERPYECNEC GKAFRQSSEL ITHQRIHSGE 450
KPYECSECGK AFSLSSNLIR HQRIHSGEEP YQCNECGKTF KRSSALVQHQ 500
RIHSGDEAYI CNECGKAFRH RSVLMRHQRV HTIK 534
Length:534
Mass (Da):61,139
Last modified:October 31, 2003 - v2
Checksum:iE990609DABABDE2A
GO
Isoform 2 (identifier: Q8NF99-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-275: SEHESNLVWK...LILTTDSIMC → KLSRPPKASS...SKNVNRKYFS
     276-534: Missing.

Note: No experimental confirmation available.

Show »
Length:275
Mass (Da):31,052
Checksum:iB745896D4FDD142E
GO
Isoform 3 (identifier: Q8NF99-3) [UniParc]FASTAAdd to Basket

Also known as: Truncated, ZNF397-nf

The sequence of this isoform differs from the canonical sequence as follows:
     186-207: DCENSETATKEGISEEKSQGLP → GEEWEIIWKLLTLRPLFLRMQN
     208-534: Missing.

Show »
Length:207
Mass (Da):24,141
Checksum:iBC397F169EF9962E
GO

Sequence cautioni

Isoform 3 : The sequence AAN65175.1 differs from that shown. Reason: Frameshift at position 194.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei186 – 20722DCENS…SQGLP → GEEWEIIWKLLTLRPLFLRM QN in isoform 3. VSP_042491Add
BLAST
Alternative sequencei208 – 534327Missing in isoform 3. VSP_042492Add
BLAST
Alternative sequencei216 – 27560SEHES…DSIMC → KLSRPPKASSAIRWECVSPG SFPGDIIAAEATHSTISCFA INTLPATILPSKNVNRKYFS in isoform 2. VSP_006924Add
BLAST
Alternative sequencei276 – 534259Missing in isoform 2. VSP_006925Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF533250 mRNA. Translation: AAM95991.2.
AY157641 mRNA. Translation: AAN65175.1. Frameshift.
BC006172 mRNA. Translation: AAH06172.1.
CCDSiCCDS32814.1. [Q8NF99-2]
CCDS45852.1. [Q8NF99-1]
RefSeqiNP_001128650.1. NM_001135178.2. [Q8NF99-1]
NP_115723.1. NM_032347.2. [Q8NF99-2]
UniGeneiHs.591061.

Genome annotation databases

EnsembliENST00000261333; ENSP00000261333; ENSG00000186812. [Q8NF99-2]
ENST00000330501; ENSP00000331577; ENSG00000186812. [Q8NF99-1]
ENST00000585800; ENSP00000466760; ENSG00000186812. [Q8NF99-3]
ENST00000591206; ENSP00000466317; ENSG00000186812. [Q8NF99-3]
GeneIDi84307.
KEGGihsa:84307.
UCSCiuc002kyi.3. human. [Q8NF99-3]
uc002kyj.3. human. [Q8NF99-2]
uc010dmp.3. human. [Q8NF99-1]

Polymorphism databases

DMDMi38258943.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF533250 mRNA. Translation: AAM95991.2 .
AY157641 mRNA. Translation: AAN65175.1 . Frameshift.
BC006172 mRNA. Translation: AAH06172.1 .
CCDSi CCDS32814.1. [Q8NF99-2 ]
CCDS45852.1. [Q8NF99-1 ]
RefSeqi NP_001128650.1. NM_001135178.2. [Q8NF99-1 ]
NP_115723.1. NM_032347.2. [Q8NF99-2 ]
UniGenei Hs.591061.

3D structure databases

ProteinModelPortali Q8NF99.
SMRi Q8NF99. Positions 47-134, 258-532.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124033. 3 interactions.
STRINGi 9606.ENSP00000331577.

PTM databases

PhosphoSitei Q8NF99.

Polymorphism databases

DMDMi 38258943.

Proteomic databases

MaxQBi Q8NF99.
PaxDbi Q8NF99.
PRIDEi Q8NF99.

Protocols and materials databases

DNASUi 84307.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261333 ; ENSP00000261333 ; ENSG00000186812 . [Q8NF99-2 ]
ENST00000330501 ; ENSP00000331577 ; ENSG00000186812 . [Q8NF99-1 ]
ENST00000585800 ; ENSP00000466760 ; ENSG00000186812 . [Q8NF99-3 ]
ENST00000591206 ; ENSP00000466317 ; ENSG00000186812 . [Q8NF99-3 ]
GeneIDi 84307.
KEGGi hsa:84307.
UCSCi uc002kyi.3. human. [Q8NF99-3 ]
uc002kyj.3. human. [Q8NF99-2 ]
uc010dmp.3. human. [Q8NF99-1 ]

Organism-specific databases

CTDi 84307.
GeneCardsi GC18P032820.
HGNCi HGNC:18818. ZNF397.
HPAi HPA026087.
MIMi 609601. gene.
neXtProti NX_Q8NF99.
PharmGKBi PA38694.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234619.
HOVERGENi HBG018163.
InParanoidi Q8NF99.
KOi K09230.
OMAi IPSIEIC.
PhylomeDBi Q8NF99.
TreeFami TF338304.

Miscellaneous databases

ChiTaRSi ZNF397. human.
GenomeRNAii 84307.
NextBioi 73992.
PROi Q8NF99.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8NF99.
Bgeei Q8NF99.
CleanExi HS_ZNF397.
Genevestigatori Q8NF99.

Family and domain databases

Gene3Di 3.30.160.60. 9 hits.
InterProi IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view ]
SUPFAMi SSF47353. SSF47353. 1 hit.
PROSITEi PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of two novel human SCAN domain-containing zinc finger genes ZNF396 and ZNF397."
    Wu Y., Yu L., Bi G., Luo K., Zhou G., Zhao S.
    Gene 310:193-201(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Hepatoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Uterus.

Entry informationi

Entry nameiZN397_HUMAN
AccessioniPrimary (citable) accession number: Q8NF99
Secondary accession number(s): Q9BRM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: October 31, 2003
Last modified: July 9, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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