Nesprin-1 - Homo sapiens (Human)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Nesprin-1

Alternative name(s):
Enaptin
Myocyte nuclear envelope protein 1
Short name=Myne-1
Nuclear envelope spectrin repeat protein 1
Synaptic nuclear envelope protein 1
Short name=Syne-1

Gene names

Name:	SYNE1
Synonyms:	C6orf98, KIAA0796, KIAA1262, KIAA1756, MYNE1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	8797 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. May be involved in the maintenance of nuclear organization and structural integrity. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm. May be required for centrosome migration to the apical cell surface during early ciliogenesis. Ref.1 Ref.18
Subunit structure	Dimer. Core component of the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN domain-containing proteins interact with A-type lamins of the nuclear lamina, while at the other end of the complex, nesprins interact with unique cytoskeletal components. Interacts with SYNE3. May interact with MUSK By similarity. Interacts with F-actin via its N-terminal domain By similarity. Interacts with EMD and LMNA in vitro.
Subcellular location	Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side Potential. Nucleus. Nucleus envelope. Cytoplasm › cytoskeleton. Cytoplasm › myofibril › sarcomere. Note: The largest part of the protein is cytoplasmic, while its C-terminal part is associated with the nuclear envelope, most probably the outer nuclear membrane. In skeletal and smooth muscles, a significant amount is found in the sarcomeres. In myoblasts, relocalized from the nuclear envelope to the nucleus and cytoplasm during cell differentiation. Ref.1 Ref.2 Ref.13
Tissue specificity	Expressed in HeLa, A431, A172 and HaCaT cells (at protein level). Widely expressed. Highly expressed in skeletal and smooth muscles, heart, spleen, peripheral blood leukocytes, pancreas, cerebellum, stomach, kidney and placenta. Ref.1 Ref.3 Ref.13 Ref.21
Domain	The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains. Ref.18
Involvement in disease	Spinocerebellar ataxia, autosomal recessive, 8 (SCAR8) [MIM:610743]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR8 is an autosomal recessive form. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.17 Emery-Dreifuss muscular dystrophy 4, autosomal dominant (EDMD4) [MIM:612998]: A form of Emery-Dreifuss muscular dystrophy, a degenerative myopathy characterized by weakness and atrophy of muscle without involvement of the nervous system, early contractures of the elbows, Achilles tendons and spine, and cardiomyopathy associated with cardiac conduction defects. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.23
Sequence similarities	Belongs to the nesprin family. Contains 1 actin-binding domain. Contains 2 CH (calponin-homology) domains. Contains 12 HAT repeats. Contains 1 KASH domain. Contains 31 spectrin repeats.
Sequence caution	The sequence AAC02992.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAL38031.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAM95335.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin. The sequence BAB71097.1 differs from that shown. Reason: Chimeric cDNA. The sequence BAC04284.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAD28486.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Membrane Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation Emery-Dreifuss muscular dystrophy Neurodegeneration
Domain	Coiled coil Repeat Transmembrane Transmembrane helix
Ligand	Actin-binding
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Golgi organization Inferred from direct assay Ref.6. Source: UniProtKB cell death Inferred from electronic annotation. Source: UniProtKB-KW cytoskeletal anchoring at nuclear membrane Inferred from direct assay Ref.18. Source: UniProtKB establishment of nucleus localization Inferred from electronic annotation. Source: Ensembl muscle cell differentiation Inferred from direct assay Ref.1. Source: UniProtKB nuclear matrix anchoring at nuclear membrane Inferred from direct assay Ref.13. Source: UniProtKB
Cellular_component	Golgi apparatus Inferred from direct assay Ref.6. Source: UniProtKB SUN-KASH complex Inferred from direct assay Ref.18. Source: UniProtKB cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell integral component of membrane Inferred from direct assay Ref.1. Source: UniProtKB nuclear membrane Inferred from direct assay. Source: HPA nuclear outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Inferred from direct assay PubMed 10878022. Source: UniProtKB sarcomere Inferred from direct assay Ref.2. Source: MGI
Molecular_function	actin binding Inferred from direct assay Ref.2. Source: UniProtKB protein homodimerization activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct
DISC1	Q9NRI5	6	EBI-928867,EBI-529989
SUN1	O94901	2	EBI-6170938,EBI-2796904
SUN2	Q9UH99	3	EBI-928867,EBI-1044964

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NF91-1) Also known as: Nesprin-1 Giant; Enaptin; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NF91-2) Also known as: Beta; The sequence of this isoform differs from the canonical sequence as follows: 1-5476: Missing.

Isoform 3 (identifier: Q8NF91-3) Also known as: Alpha; The sequence of this isoform differs from the canonical sequence as follows: 1-7838: Missing. 8325-8325: S → SDVMIPESPEAYVKLTENAIKNTS

Isoform 4 (identifier: Q8NF91-4) The sequence of this isoform differs from the canonical sequence as follows: 103-103: K → KSMHRGSP 3620-3641: Missing. 3912-3967: Missing. 8325-8325: S → SDVMIPESPEAYVKLTENAIKNTS

Isoform 5 (identifier: Q8NF91-5) The sequence of this isoform differs from the canonical sequence as follows: 1437-1443: DIKTMEM → EYVIDKS 1444-8797: Missing.
Note: No experimental confirmation available.

Isoform 6 (identifier: Q8NF91-6) The sequence of this isoform differs from the canonical sequence as follows: 1702-1725: LQNEVVSQASFYSKLLQLKESLFS → SSRKCEEGKNKMLFVTVTLFKIIK 1726-8797: Missing.
Note: No experimental confirmation available.

Isoform 7 (identifier: Q8NF91-7) The sequence of this isoform differs from the canonical sequence as follows: 5571-5580: TLLEESKEID → VTLGKIIFKK 5581-8797: Missing.
Note: No experimental confirmation available.

Isoform 8 (identifier: Q8NF91-8) Also known as: Beta 2; The sequence of this isoform differs from the canonical sequence as follows: 1-5585: Missing.

Isoform 9 (identifier: Q8NF91-9) Also known as: Alpha 2; The sequence of this isoform differs from the canonical sequence as follows: 1-7843: Missing. 7844-7874: AKASHESKASEIEYKLGKVNDRWQHLLDLIA → MVVAEDLSALRMAEDGCVDADLPDCNCDVTR 8325-8325: S → SDVMIPESPEAYVKLTENAIKNTS

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 8797

8797

Nesprin-1

PRO_0000163591

Regions

Topological domain

1 – 8746

8746

Cytoplasmic Potential

Transmembrane

8747 – 8767

21

Helical; Anchor for type IV membrane protein; Potential

Topological domain

8768 – 8797

30

Perinuclear space Potential

Domain

1 – 289

289

Actin-binding

Domain

27 – 134

108

CH 1

Domain

178 – 283

106

CH 2

Repeat

592 – 624

33

HAT 1

Repeat

1103 – 1135

33

HAT 2

Repeat

1425 – 1457

33

HAT 3

Repeat

1630 – 1652

23

Spectrin 1

Repeat

1655 – 1762

108

Spectrin 2

Repeat

2176 – 2208

33

HAT 4

Repeat

2339 – 2405

67

Spectrin 3

Repeat

2406 – 2512

107

Spectrin 4

Repeat

2515 – 2615

101

Spectrin 5

Repeat

2705 – 2744

40

HAT 5

Repeat

3173 – 3277

105

Spectrin 6

Repeat

3348 – 3386

39

Spectrin 7

Repeat

3361 – 3400

40

HAT 6

Repeat

3492 – 3510

19

Spectrin 8

Repeat

3555 – 3588

34

HAT 7

Repeat

3816 – 3907

92

Spectrin 9

Repeat

3967 – 4033

67

Spectrin 10

Repeat

4146 – 4238

93

Spectrin 11

Repeat

4261 – 4337

77

Spectrin 12

Repeat

4486 – 4559

74

Spectrin 13

Repeat

4750 – 4775

26

Spectrin 14

Repeat

4993 – 5035

43

Spectrin 15

Repeat

5101 – 5208

108

Spectrin 16

Repeat

5569 – 5629

61

Spectrin 17

Repeat

5632 – 5690

59

Spectrin 18

Repeat

5738 – 5799

62

Spectrin 19

Repeat

5963 – 6070

108

Spectrin 20

Repeat

6774 – 6806

33

HAT 8

Repeat

6795 – 6904

110

Spectrin 21

Repeat

7001 – 7033

33

HAT 9

Repeat

7022 – 7127

106

Spectrin 22

Repeat

7162 – 7230

69

Spectrin 23

Repeat

7211 – 7250

40

HAT 10

Repeat

7352 – 7453

102

Spectrin 24

Repeat

7456 – 7560

105

Spectrin 25

Repeat

7542 – 7574

33

HAT 11

Repeat

7697 – 7777

81

Spectrin 26

Repeat

7780 – 7882

103

Spectrin 27

Repeat

7885 – 7996

112

Spectrin 28

Repeat

7975 – 8007

33

HAT 12

Repeat

7999 – 8105

107

Spectrin 29

Repeat

8108 – 8212

105

Spectrin 30

Repeat

8440 – 8547

108

Spectrin 31

Domain

8738 – 8797

60

KASH

Coiled coil

327 – 347

21

Potential

Coiled coil

433 – 463

31

Potential

Coiled coil

625 – 650

26

Potential

Coiled coil

817 – 844

28

Potential

Coiled coil

925 – 955

31

Potential

Coiled coil

991 – 1011

21

Potential

Coiled coil

1197 – 1217

21

Potential

Coiled coil

1270 – 1447

178

Potential

Coiled coil

1549 – 1577

29

Potential

Coiled coil

1810 – 1830

21

Potential

Coiled coil

1899 – 1934

36

Potential

Coiled coil

1969 – 2035

67

Potential

Coiled coil

2086 – 2106

21

Potential

Coiled coil

2166 – 2270

105

Potential

Coiled coil

2606 – 2636

31

Potential

Coiled coil

2780 – 2807

28

Potential

Coiled coil

2944 – 2992

49

Potential

Coiled coil

3773 – 3813

41

Potential

Coiled coil

4101 – 4130

30

Potential

Coiled coil

4590 – 4611

22

Potential

Coiled coil

4852 – 4872

21

Potential

Coiled coil

4913 – 4945

33

Potential

Coiled coil

5293 – 5313

21

Potential

Coiled coil

5350 – 5459

110

Potential

Coiled coil

6420 – 6438

19

Potential

Coiled coil

6524 – 6610

87

Potential

Coiled coil

6693 – 6712

20

Potential

Coiled coil

8327 – 8401

75

Potential

Coiled coil

8630 – 8662

33

Potential

Compositional bias

8663 – 8729

67

Ser-rich

Amino acid modifications

Modified residue

8223

1

Phosphoserine Ref.16

Modified residue

8274

1

Phosphothreonine Ref.16

Modified residue

8277

1

Phosphoserine Ref.16

Modified residue

8280

1

Phosphoserine Ref.16

Modified residue

8305

1

Phosphoserine By similarity

Natural variations

Alternative sequence

1 – 7843

7843

Missing in isoform 9.

VSP_007133

Alternative sequence

1 – 7838

7838

Missing in isoform 3.

VSP_007132

Alternative sequence

1 – 5585

5585

Missing in isoform 8.

VSP_007131

Alternative sequence

1 – 5476

5476

Missing in isoform 2.

VSP_007130

Alternative sequence

103

1

K → KSMHRGSP in isoform 4.

VSP_007134

Alternative sequence

1437 – 1443

7

DIKTMEM → EYVIDKS in isoform 5.

VSP_007135

Alternative sequence

1444 – 8797

7354

Missing in isoform 5.

VSP_007136

Alternative sequence

1702 – 1725

24

LQNEV…ESLFS → SSRKCEEGKNKMLFVTVTLF KIIK in isoform 6.

VSP_007137

Alternative sequence

1726 – 8797

7072

Missing in isoform 6.

VSP_007138

Alternative sequence

3620 – 3641

22

Missing in isoform 4.

VSP_007139

Alternative sequence

3912 – 3967

56

Missing in isoform 4.

VSP_007140

Alternative sequence

5571 – 5580

10

TLLEESKEID → VTLGKIIFKK in isoform 7.

VSP_007141

Alternative sequence

5581 – 8797

3217

Missing in isoform 7.

VSP_007142

Alternative sequence

7844 – 7874

31

AKASH…LDLIA → MVVAEDLSALRMAEDGCVDA DLPDCNCDVTR in isoform 9.

VSP_007143

Alternative sequence

8325

1

S → SDVMIPESPEAYVKLTENAI KNTS in isoform 3, isoform 4 and isoform 9.

VSP_007144

Natural variant

655

1

Q → R.
Corresponds to variant rs9397509 [ dbSNP | Ensembl ].

VAR_056211

Natural variant

885

1

L → V.
Corresponds to variant rs17082709 [ dbSNP | Ensembl ].

VAR_056212

Natural variant

1035

1

V → A.
Corresponds to variant rs214976 [ dbSNP | Ensembl ].

VAR_056213

Natural variant

2030

1

S → G.
Corresponds to variant rs35763277 [ dbSNP | Ensembl ].

VAR_056214

Natural variant

2795

1

A → V.
Corresponds to variant rs214950 [ dbSNP | Ensembl ].

VAR_056215

Natural variant

3671

1

V → M in a colorectal cancer sample; somatic mutation. Ref.22

VAR_036250

Natural variant

3874

1

K → T.
Corresponds to variant rs13210127 [ dbSNP | Ensembl ].

VAR_056216

Natural variant

3954

1

S → T.
Corresponds to variant rs7775119 [ dbSNP | Ensembl ].

VAR_056217

Natural variant

4060

1

E → D.
Corresponds to variant rs4645434 [ dbSNP | Ensembl ].

VAR_056218

Natural variant

4121

1

K → N.
Corresponds to variant rs28385621 [ dbSNP | Ensembl ].

VAR_056219

Natural variant

4121

1

K → R.
Corresponds to variant rs9479297 [ dbSNP | Ensembl ].

VAR_056220

Natural variant

4203

1

E → K.
Corresponds to variant rs2130262 [ dbSNP | Ensembl ].

VAR_056221

Natural variant

4210

1

E → D in a colorectal cancer sample; somatic mutation. Ref.22

VAR_036251

Natural variant

4223

1

R → H in a colorectal cancer sample; somatic mutation. Ref.22

VAR_036252

Natural variant

4546

1

V → I.
Corresponds to variant rs4870093 [ dbSNP | Ensembl ].

VAR_056222

Natural variant

4596

1

S → T. Ref.2 Ref.10
Corresponds to variant rs6911096 [ dbSNP | Ensembl ].

VAR_056223

Natural variant

4944

1

L → M.
Corresponds to variant rs2306916 [ dbSNP | Ensembl ].

VAR_056224

Natural variant

5015

1

L → M. Ref.2 Ref.10
Corresponds to variant rs2306916 [ dbSNP | Ensembl ].

VAR_056225

Natural variant

5377

1

M → L.
Corresponds to variant rs35987150 [ dbSNP | Ensembl ].

VAR_056226

Natural variant

5426

1

T → M.
Corresponds to variant rs2306914 [ dbSNP | Ensembl ].

VAR_056227

Natural variant

5507

1

L → R in a colorectal cancer sample; somatic mutation. Ref.22

VAR_036253

Natural variant

6566

1

M → I.
Corresponds to variant rs35654757 [ dbSNP | Ensembl ].

VAR_056228

Natural variant

6664

1

T → I.
Corresponds to variant rs35079654 [ dbSNP | Ensembl ].

VAR_056229

Natural variant

6951

1

Q → H.
Corresponds to variant rs3945783 [ dbSNP | Ensembl ].

VAR_056230

Natural variant

7302

1

F → V. Ref.1 Ref.2 Ref.4 Ref.11
Corresponds to variant rs2147377 [ dbSNP | Ensembl ].

VAR_056231

Natural variant

7506

1

S → G.
Corresponds to variant rs35763277 [ dbSNP | Ensembl ].

VAR_056232

Natural variant

8095

1

R → H in EDMD4. Ref.23

VAR_062974

Natural variant

8161

1

N → H.
Corresponds to variant rs36215251 [ dbSNP | Ensembl ].

VAR_056233

Natural variant

8168

1

A → S.
Corresponds to variant rs17082236 [ dbSNP | Ensembl ].

VAR_056234

Natural variant

8323

1

G → A. Ref.1 Ref.2 Ref.4 Ref.11 Ref.13
Corresponds to variant rs2252755 [ dbSNP | Ensembl ].

VAR_015548

Natural variant

8387

1

V → L in EDMD4. Ref.23

VAR_062975

Natural variant

8461

1

E → K in EDMD4. Ref.23
Corresponds to variant rs119103248 [ dbSNP | Ensembl ].

VAR_062976

Natural variant

8468

1

R → H in a colorectal cancer sample; somatic mutation. Ref.22

VAR_036254

Natural variant

8687

1

T → I.
Corresponds to variant rs35591210 [ dbSNP | Ensembl ].

VAR_056235

Natural variant

8741

1

L → M.
Corresponds to variant rs2295190 [ dbSNP | Ensembl ].

VAR_056236

Experimental info

Mutagenesis

8758 – 8763

6

Missing: Abolishes the nuclear envelope targeting, induces a cytoplasmic localization. Ref.1

Sequence conflict

98

1

F → L in AAN60442. Ref.2

Sequence conflict

494

1

S → P in AAM95335. Ref.6

Sequence conflict

1440

1

T → P in CAD28486. Ref.9

Sequence conflict

3096

1

N → D in BAB71097. Ref.7

Sequence conflict

5526

1

A → T in AAL33798. Ref.1

Sequence conflict

5564

1

E → K in AAL33798. Ref.1

Sequence conflict

5735

1

E → A in AAN03486. Ref.3

Sequence conflict

6549

1

K → E in AAL33798. Ref.1

Sequence conflict

6549

1

K → E in AAN60442. Ref.2

Sequence conflict

6549

1

K → E in AAO27774. Ref.4

Sequence conflict

6626

1

L → P in AAL33798. Ref.1

Sequence conflict

6626

1

L → P in AAN60442. Ref.2

Sequence conflict

6626

1

L → P in AAO27774. Ref.4

Sequence conflict

6645

1

E → V in AAL33798. Ref.1

Sequence conflict

6645

1

E → V in AAN60442. Ref.2

Sequence conflict

6645

1

E → V in AAO27774. Ref.4

Sequence conflict

6923

1

I → T in AAL33798. Ref.1

Sequence conflict

6923

1

I → T in AAN60442. Ref.2

Sequence conflict

6923

1

I → T in AAO27774. Ref.4

Sequence conflict

6929

1

V → A in AAL33798. Ref.1

Sequence conflict

6929

1

V → A in AAN60442. Ref.2

Sequence conflict

6929

1

V → A in AAO27774. Ref.4

Sequence conflict

7075

1

E → D in AAL33798. Ref.1

Sequence conflict

7075

1

E → D in AAN60442. Ref.2

Sequence conflict

7075

1

E → D in AAO27774. Ref.4

Sequence conflict

7091

1

N → T in AAL33798. Ref.1

Sequence conflict

7091

1

N → T in AAN60442. Ref.2

Sequence conflict

7091

1

N → T in AAO27774. Ref.4

Secondary structure

1

.

8797

Helix Strand Turn

Details...

Sequences

Sequence		Length	Mass (Da)
Isoform 1 (Nesprin-1 Giant) (Enaptin) [UniParc]. Last modified November 28, 2012. Version 4. Checksum: 02A53B8AFBF34A17 Show »	FASTA	8,797	1,011,086
10 20 30 40 50 60 MATSRGASRC PRDIANVMQR LQDEQEIVQK RTFTKWINSH LAKRKPPMVV DDLFEDMKDG 70 80 90 100 110 120 VKLLALLEVL SGQKLPCEQG RRMKRIHAVA NIGTALKFLE GRKIKLVNIN STDIADGRPS 130 140 150 160 170 180 IVLGLMWTII LYFQIEELTS NLPQLQSLSS SASSVDSIVS SETPSPPSKR KVTTKIQGNA 190 200 210 220 230 240 KKALLKWVQY TAGKQTGIEV KDFGKSWRSG VAFHSVIHAI RPELVDLETV KGRSNRENLE 250 260 270 280 290 300 DAFTIAETEL GIPRLLDPED VDVDKPDEKS IMTYVAQFLK HYPDIHNAST DGQEDDEILP 310 320 330 340 350 360 GFPSFANSVQ NFKREDRVIF KEMKVWIEQF ERDLTRAQMV ESNLQDKYQS FKHFRVQYEM 370 380 390 400 410 420 KRKQIEHLIQ PLHRDGKLSL DQALVKQSWD RVTSRLFDWH IQLDKSLPAP LGTIGAWLYR 430 440 450 460 470 480 AEVALREEIT VQQVHEETAN TIQRKLEQHK DLLQNTDAHK RAFHEIYRTR SVNGIPVPPD 490 500 510 520 530 540 QLEDMAERFH FVSSTSELHL MKMEFLELKY RLLSLLVLAE SKLKSWIIKY GRRESVEQLL 550 560 570 580 590 600 QNYVSFIENS KFFEQYEVTY QILKQTAEMY VKADGSVEEA ENVMKFMNET TAQWRNLSVE 610 620 630 640 650 660 VRSVRSMLEE VISNWDRYGN TVASLQAWLE DAEKMLNQSE NAKKDFFRNL PHWIQQHTAM 670 680 690 700 710 720 NDAGNFLIET CDEMVSRDLK QQLLLLNGRW RELFMEVKQY AQADEMDRMK KEYTDCVVTL 730 740 750 760 770 780 SAFATEAHKK LSEPLEVSFM NVKLLIQDLE DIEQRVPVMD AQYKIITKTA HLITKESPQE 790 800 810 820 830 840 EGKEMFATMS KLKEQLTKVK ECYSPLLYES QQLLIPLEEL EKQMTSFYDS LGKINEIITV 850 860 870 880 890 900 LEREAQSSAL FKQKHQELLA CQENCKKTLT LIEKGSQSVQ KFVTLSNVLK HFDQTRLQRQ 910 920 930 940 950 960 IADIHVAFQS MVKKTGDWKK HVETNSRLMK KFEESRAELE KVLRIAQEGL EEKGDPEELL 970 980 990 1000 1010 1020 RRHTEFFSQL DQRVLNAFLK ACDELTDILP EQEQQGLQEA VRKLHKQWKD LQGEAPYHLL 1030 1040 1050 1060 1070 1080 HLKIDVEKNR FLASVEECRT ELDRETKLMP QEGSEKIIKE HRVFFSDKGP HHLCEKRLQL 1090 1100 1110 1120 1130 1140 IEELCVKLPV RDPVRDTPGT CHVTLKELRA AIDSTYRKLM EDPDKWKDYT SRFSEFSSWI 1150 1160 1170 1180 1190 1200 STNETQLKGI KGEAIDTANH GEVKRAVEEI RNGVTKRGET LSWLKSRLKV LTEVSSENEA 1210 1220 1230 1240 1250 1260 QKQGDELAKL SSSFKALVTL LSEVEKMLSN FGDCVQYKEI VKNSLEELIS GSKEVQEQAE 1270 1280 1290 1300 1310 1320 KILDTENLFE AQQLLLHHQQ KTKRISAKKR DVQQQIAQAQ QGEGGLPDRG HEELRKLEST 1330 1340 1350 1360 1370 1380 LDGLERSRER QERRIQVTLR KWERFETNKE TVVRYLFQTG SSHERFLSFS SLESLSSELE 1390 1400 1410 1420 1430 1440 QTKEFSKRTE SIAVQAENLV KEASEIPLGP QNKQLLQQQA KSIKEQVKKL EDTLEEDIKT 1450 1460 1470 1480 1490 1500 MEMVKTKWDH FGSNFETLSV WITEKEKELN ALETSSSAMD MQISQIKVTI QEIESKLSSI 1510 1520 1530 1540 1550 1560 VGLEEEAQSF AQFVTTGESA RIKAKLTQIR RYGEELREHA QCLEGTILGH LSQQQKFEEN 1570 1580 1590 1600 1610 1620 LRKIQQSVSE FEDKLAVPIK ICSSATETYK VLQEHMDLCQ ALESLSSAIT AFSASARKVV 1630 1640 1650 1660 1670 1680 NRDSCVQEAA ALQQQYEDIL RRAKERQTAL ENLLAHWQRL EKELSSFLTW LERGEAKASS 1690 1700 1710 1720 1730 1740 PEMDISADRV KVEGELQLIQ ALQNEVVSQA SFYSKLLQLK ESLFSVASKD DVKMMKLHLE 1750 1760 1770 1780 1790 1800 QLDERWRDLP QIINKRINFL QSVVAEHQQF DELLLSFSVW IKLFLSELQT TSEISIMDHQ 1810 1820 1830 1840 1850 1860 VALTRHKDHA AEVESKKGEL QSLQGHLAKL GSLGRAEDLH LLQGKAEDCF QLFEEASQVV 1870 1880 1890 1900 1910 1920 ERRQLALSHL AEFLQSHASL SGILRQLRQT VEATNSMNKN ESDLIEKDLN DALQNAKALE 1930 1940 1950 1960 1970 1980 SAAVSLDGIL SKAQYHLKIG SSEQRTSCRA TADQLCGEVE RIQNLLGTKQ SEADALAVLK 1990 2000 2010 2020 2030 2040 KAFQDQKEEL LKSIEDIEER TDKERLKEPT RQALQQRLRV FNQLEDELNS HEHELCWLKD 2050 2060 2070 2080 2090 2100 KAKQIAQKDV AFAPEVDREI NRLEVTWDDT KRLIHENQGQ CCGLIDLMRE YQNLKSAVSK 2110 2120 2130 2140 2150 2160 VLENASSVIV TRTTIKDQED LKWAFSKHET AKNKMNYKQK DLDNFTSKGK HLLSELKKIH 2170 2180 2190 2200 2210 2220 SSDFSLVKTD MESTVDKWLD VSEKLEENMD RLRVSLSIWD DVLSTRDEIE GWSNNCVPQM 2230 2240 2250 2260 2270 2280 AENISNLDNH LRAEELLKEF ESEVKNKALR LEELHSKVND LKELTKNLET PPDLQFIEAD 2290 2300 2310 2320 2330 2340 LMQKLEHAKE ITEVAKGTLK DFTAQSTQVE KFINDITTWF TKVEESLMNC AQNETCEALK 2350 2360 2370 2380 2390 2400 KVKDIQKELQ SQQSNISSTQ ENLNSLCRKY HSAELESLGR AMTGLIKKHE AVSQLCSKTQ 2410 2420 2430 2440 2450 2460 ASLQESLEKH FSESMQEFQE WFLGAKAAAK ESSDRTGDSK VLEAKLHDLQ NILDSVSDGQ 2470 2480 2490 2500 2510 2520 SKLDAVTQEG QTLYAHLSKQ IVSSIQEQIT KANEEFQAFL KQCLKDKQAL QDCASELGSF 2530 2540 2550 2560 2570 2580 EDQHRKLNLW IHEMEERFNT ENLGESKQHI PEKKNEVHKV EMFLGELLAA RESLDKLSQR 2590 2600 2610 2620 2630 2640 GQLLSEEGHG AGQEGRLCSQ LLTSHQNLLR MTKEKLRSCQ VALQEHEALE EALQSMWFWV 2650 2660 2670 2680 2690 2700 KAIQDRLACA ESTLGSKDTL EKRLSQIQDI LLMKGEGEVK LNMAIGKGEQ ALRSSNKEGQ 2710 2720 2730 2740 2750 2760 RVIQTQLETL KEVWADIMSS SVHAQSTLES VISQWNDYVE RKNQLEQWME SVDQKIEHPL 2770 2780 2790 2800 2810 2820 QPQPGLKEKF VLLDHLQSIL SEAEDHTRAL HRLIAKSREL YEKTEDESFK DTAQEELKTQ 2830 2840 2850 2860 2870 2880 FNDIMTVAKE KMRKVEEIVK DHLMYLDAVH EFTDWLHSAK EELHRWSDMS GDSSATQKKL 2890 2900 2910 2920 2930 2940 SKIKELIDSR EIGASRLSRV ESLAPEVKQN TTASGCELMH TEMQALRADW KQWEDSVFQT 2950 2960 2970 2980 2990 3000 QSCLENLVSQ MALSEQEFSG QVAQLEQALE QFSALLKTWA QQLTLLEGKN TDEEIVECWH 3010 3020 3030 3040 3050 3060 KGQEILDALQ KAEPRTEDLK SQLNELCRFS RDLSTYSGKV SGLIKEYNCL CLQASKGCQN 3070 3080 3090 3100 3110 3120 KEQILQQRFR KAFRDFQQWL VNAKITTAKC FDIPQNISEV STSLQKIQEF LSESENGQHK 3130 3140 3150 3160 3170 3180 LNMMLSKGEL LSTLLTKEKA KGIQAKVTAA KEDWKNFHSN LHQKESALEN LKIQMKDFEV 3190 3200 3210 3220 3230 3240 SAEPIQDWLS KTEKMVHESS NRLYDLPAKR REQQKLQSVL EEIHCYEPQL NRLKEKAQQL 3250 3260 3270 3280 3290 3300 WEGQAASKSF RHRVSQLSSQ YLALSNLTKE KVSRLDRIVA EHNQFSLGIK ELQDWMTDAI 3310 3320 3330 3340 3350 3360 HMLDSYCHPT SDKSVLDSRT LKLEALLSVK QEKEIQMKMI VTRGESVLQN TSPEGIPTIQ 3370 3380 3390 3400 3410 3420 QQLQSVKDMW ASLLSAGIRC KSQLEGALSK WTSYQDGVRQ FSGWMDSMEA NLNESERQHA 3430 3440 3450 3460 3470 3480 ELRDKTTMLG KAKLLNEEVL SYSSLLETIE VKGAGMTEHY VTQLELQDLQ ERYRAIQERA 3490 3500 3510 3520 3530 3540 KEAVTKSEKL VRLHQEYQRD LKAFEVWLGQ EQEKLDQYSV LEGDAHTHET TLRDLQELQV 3550 3560 3570 3580 3590 3600 HCAEGQALLN SVLHTREDVI PSGIPQAEDR ALESLRQDWQ AYQHRLSETR TQFNNVVNKL 3610 3620 3630 3640 3650 3660 RLMEQKFQQV DEWLKTAEEK VSPRTRRQSN RATKEIQLHQ MKKWHEEVTA YRDEVEEVGA 3670 3680 3690 3700 3710 3720 RAQEILDESH VNSRMGCQAT QLTSRYQALL LQVLEQIKFL EEEIQSLEES ESSLSSYSDW 3730 3740 3750 3760 3770 3780 YGSTHKNFKN VATKIDKVDT VMMGKKLKTL EVLLKDMEKG HSLLKSAREK GERAVKYLEE 3790 3800 3810 3820 3830 3840 GEAERLRKEI HDHMEQLKEL TSTVRKEHMT LEKGLHLAKE FSDKCKALTQ WIAEYQEILH 3850 3860 3870 3880 3890 3900 VPEEPKMELY EKKAQLSKYK SLQQTVLSHE PSVKSVREKG EALLELVQDV TLKDKIDQLQ 3910 3920 3930 3940 3950 3960 SDYQDLCSIG KEHVFSLEAK VKDHEDYNSE LQEVEKWLLQ MSGRLVAPDL LETSSLETIT 3970 3980 3990 4000 4010 4020 QQLAHHKAMM EEIAGFEDRL NNLQMKGDTL IGQCADHLQA KLKQNVHAHL QGTKDSYSAI 4030 4040 4050 4060 4070 4080 CSTAQRMYQS LEHELQKHVS RQDTLQQCQA WLSAVQPDLE PSPQPPLSRA EAIKQVKHFR 4090 4100 4110 4120 4130 4140 ALQEQARTYL DLLCSMCDLS NASVKTTAKD IQQTEQTIEQ KLVQAQNLTQ GWEEIKHLKS 4150 4160 4170 4180 4190 4200 ELWIYLQDAD QQLQNMKRRH SELELNIAQN MVSQVKDFVK KLQSKQASVN TIIEKVNKLT 4210 4220 4230 4240 4250 4260 KKEESPEHKE INHLNDQWLD LCRQSNNLCL QREEDLQRTR DYHDCMNVVE VFLEKFTTEW 4270 4280 4290 4300 4310 4320 DNLARSDAES TAVHLEALKK LALALQERKY AIEDLKDQKQ KMIEHLNLDD KELVKEQTSH 4330 4340 4350 4360 4370 4380 LEQRWFQLED LIKRKIQVSV TNLEELNVVQ SRFQELMEWA EEQQPNIAEA LKQSPPPDMA 4390 4400 4410 4420 4430 4440 QNLLMDHLAI CSELEAKQML LKSLIKDADR VMADLGLNER QVIQKALSDA QSHVNCLSDL 4450 4460 4470 4480 4490 4500 VGQRRKYLNK ALSEKTQFLM AVFQATSQIQ QHERKIMFRE HICLLPDDVS KQVKTCKSAQ 4510 4520 4530 4540 4550 4560 ASLKTYQNEV TGLWAQGREL MKEVTEQEKS EVLGKLQELQ SVYDSVLQKC SHRLQELEKN 4570 4580 4590 4600 4610 4620 LVSRKHFKED FDKACHWLKQ ADIVTFPEIN LMNESSELHT QLAKYQNILE QSPEYENLLL 4630 4640 4650 4660 4670 4680 TLQRTGQTIL PSLNEVDHSY LSEKLNALPR QFNVIVALAK DKFYKVQEAI LARKEYASLI 4690 4700 4710 4720 4730 4740 ELTTQSLSEL EAQFLRMSKV PTDLAVEEAL SLQDGCRAIL DEVAGLGEAV DELNQKKEGF 4750 4760 4770 4780 4790 4800 RSTGQPWQPD KMLHLVTLYH RLKRQTEQRV SLLEDTTSAY QEHEKMCQQL ERQLKSVKEE 4810 4820 4830 4840 4850 4860 QSKVNEETLP AEEKLKMYHS LAGSLQDSGI VLKRVTIHLE DLAPHLDPLA YEKARHQIQS 4870 4880 4890 4900 4910 4920 WQGELKLLTS AIGETVTECE SRMVQSIDFQ TEMSRSLDWL RRVKAELSGP VYLDLNLQDI 4930 4940 4950 4960 4970 4980 QEEIRKIQIH QEEVQSSLRI MNALSHKEKE KFTKAKELIS ADLEHSLAEL SELDGDIQEA 4990 5000 5010 5020 5030 5040 LRTRQATLTE IYSQCQRYYQ VFQAANDWLE DAQELLQLAG NGLDVESAEE NLKSHMEFFS 5050 5060 5070 5080 5090 5100 TEDQFHSNLE ELHSLVATLD PLIKPTGKED LEQKVASLEL RSQRMSRDSG AQVDLLQRCT 5110 5120 5130 5140 5150 5160 AQWHDYQKAR EEVIELMNDT EKKLSEFSLL KTSSSHEAEE KLSEHKALVS VVNSFHEKIV 5170 5180 5190 5200 5210 5220 ALEEKASQLE KTGNDASKAT LSRSMTTVWQ RWTRLRAVAQ DQEKILEDAV DEWTGFNNKV 5230 5240 5250 5260 5270 5280 KKATEMIDQL QDKLPGSSAE KASKAELLTL LEYHDTFVLE LEQQQSALGM LRQQTLSMLQ 5290 5300 5310 5320 5330 5340 DGAAPTPGEE PPLMQEITAM QDRCLNMQEK VKTNGKLVKQ ELKDREMVET QINSVKCWVQ 5350 5360 5370 5380 5390 5400 ETKEYLGNPT IEIDAQLEEL QILLTEATNH RQNIEKMAEE QKEKYLGLYT ILPSELSLQL 5410 5420 5430 5440 5450 5460 AEVALDLKIR DQIQDKIKEV EQSKATSQEL SRQIQKLAKD LTTILTKLKA KTDNVVQAKT 5470 5480 5490 5500 5510 5520 DQKVLGEELD GCNSKLMELD AAVQKFLEQN GQLGKPLAKK IGKLTELHQQ TIRQAENRLS 5530 5540 5550 5560 5570 5580 KLNQAASHLE EYNEMLELIL KWIEKAKVLA HGTIAWNSAS QLREQYILHQ TLLEESKEID 5590 5600 5610 5620 5630 5640 SELEAMTEKL QYLTSVYCTE KMSQQVAELG RETEELRQMI KIRLQNLQDA AKDMKKFEAE 5650 5660 5670 5680 5690 5700 LKKLQAALEQ AQATLTSPEV GRLSLKEQLS HRQHLLSEME SLKPKVQAVQ LCQSALRIPE 5710 5720 5730 5740 5750 5760 DVVASLPLCH AALRLQEEAS RLQHTAIQQC NIMQEAVVQY EQYEQEMKHL QQLIEGAHRE 5770 5780 5790 5800 5810 5820 IEDKPVATSN IQELQAQISR HEELAQKIKG YQEQIASLNS KCKMLTMKAK HATMLLTVTE 5830 5840 5850 5860 5870 5880 VEGLAEGTED LDGELLPTPS AHPSVVMMTA GRCHTLLSPV TEESGEEGTN SEISSPPACR 5890 5900 5910 5920 5930 5940 SPSPVANTDA SVNQDIAYYQ ALSAERLQTD AAKIHPSTSA SQEFYEPGLE PSATAKLGDL 5950 5960 5970 5980 5990 6000 QRSWETLKNV ISEKQRTLYE ALERQQKYQD SLQSISTKME AIELKLSESP EPGRSPESQM 6010 6020 6030 6040 6050 6060 AEHQALMDEI LMLQDEINEL QSSLAEELVS ESCEADPAEQ LALQSTLTVL AERMSTIRMK 6070 6080 6090 6100 6110 6120 ASGKRQLLEE KLNDQLEEQR QEQALQRYRC EADELDSWLL STKATLDTAL SPPKEPMDME 6130 6140 6150 6160 6170 6180 AQLMDCQNML VEIEQKVVAL SELSVHNENL LLEGKAHTKD EAEQLAGKLR RLKGSLLELQ 6190 6200 6210 6220 6230 6240 RALHDKQLNM QGTAQEKEES DVDLTATQSP GVQEWLAQAR TTWTQQRQSS LQQQKELEQE 6250 6260 6270 6280 6290 6300 LAEQKSLLRS VASRGEEILI QHSAAETSGD AGEKPDVLSQ ELGMEGEKSS AEDQMRMKWE 6310 6320 6330 6340 6350 6360 SLHQEFSTKQ KLLQNVLEQE QEQVLYSRPN RLLSGVPLYK GDVPTQDKSA VTSLLDGLNQ 6370 6380 6390 6400 6410 6420 AFEEVSSQSG GAKRQSIHLE QKLYDGVSAT STWLDDVEER LFVATALLPE ETETCLFNQE 6430 6440 6450 6460 6470 6480 ILAKDIKEMS EEMDKNKNLF SQAFPENGDN RDVIEDTLGC LLGRLSLLDS VVNQRCHQMK 6490 6500 6510 6520 6530 6540 ERLQQILNFQ NDLKVLFTSL ADNKYIILQK LANVFEQPVA EQIEAIQQAE DGLKEFDAGI 6550 6560 6570 6580 6590 6600 IELKRRGDKL QVEQPSMQEL SKLQDMYDEL MMIIGSRRSG LNQNLTLKSQ YERALQDLAD 6610 6620 6630 6640 6650 6660 LLETGQEKMA GDQKIIVSSK EEIQQLLDKH KEYFQGLESH MILTETLFRK IISFAVQKET 6670 6680 6690 6700 6710 6720 QFHTELMAQA SAVLKRAHKR GVELEYILET WSHLDEDQQE LSRQLEVVES SIPSVGLVEE 6730 6740 6750 6760 6770 6780 NEDRLIDRIT LYQHLKSSLN EYQPKLYQVL DDGKRLLISI SCSDLESQLN QLGECWLSNT 6790 6800 6810 6820 6830 6840 NKMSKELHRL ETILKHWTRY QSESADLIHW LQSAKDRLEF WTQQSVTVPQ ELEMVRDHLN 6850 6860 6870 6880 6890 6900 AFLEFSKEVD AQSSLKSSVL STGNQLLRLK KVDTATLRSE LSRIDSQWTD LLTNIPAVQE 6910 6920 6930 6940 6950 6960 KLHQLQMDKL PSRHAISEVM SWISLMENVI QKDEDNIKNS IGYKAIHEYL QKYKGFKIDI 6970 6980 6990 7000 7010 7020 NCKQLTVDFV NQSVLQISSQ DVESKRSDKT DFAEQLGAMN KSWQILQGLV TEKIQLLEGL 7030 7040 7050 7060 7070 7080 LESWSEYENN VQCLKTWFET QEKRLKQQHR IGDQASVQNA LKDCQDLEDL IKAKEKEVEK 7090 7100 7110 7120 7130 7140 IEQNGLALIQ NKKEDVSSIV MSTLRELGQT WANLDHMVGQ LKILLKSVLD QWSSHKVAFD 7150 7160 7170 7180 7190 7200 KINSYLMEAR YSLSRFRLLT GSLEAVQVQV DNLQNLQDDL EKQERSLQKF GSITNQLLKE 7210 7220 7230 7240 7250 7260 CHPPVTETLT NTLKEVNMRW NNLLEEIAEQ LQSSKALLQL WQRYKDYSKQ CASTVQQQED 7270 7280 7290 7300 7310 7320 RTNELLKAAT NKDIADDEVA TWIQDCNDLL KGLGTVKDSL FFLHELGEQL KQQVDASAAS 7330 7340 7350 7360 7370 7380 AIQSDQLSLS QHLCALEQAL CKQQTSLQAG VLDYETFAKS LEALEAWIVE AEEILQGQDP 7390 7400 7410 7420 7430 7440 SHSSDLSTIQ ERMEELKGQM LKFSSMAPDL DRLNELGYRL PLNDKEIKRM QNLNRHWSLI 7450 7460 7470 7480 7490 7500 SSQTTERFSK LQSFLLQHQT FLEKCETWME FLVQTEQKLA VEISGNYQHL LEQQRAHELF 7510 7520 7530 7540 7550 7560 QAEMFSRQQI LHSIIIDGQR LLEQGQVDDR DEFNLKLTLL SNQWQGVIRR AQQRRGIIDS 7570 7580 7590 7600 7610 7620 QIRQWQRYRE MAEKLRKWLV EVSYLPMSGL GSVPIPLQQA RTLFDEVQFK EKVFLRQQGS 7630 7640 7650 7660 7670 7680 YILTVEAGKQ LLLSADSGAE AALQAELAEI QEKWKSASMR LEEQKKKLAF LLKDWEKCEK 7690 7700 7710 7720 7730 7740 GIADSLEKLR TFKKKLSQSL PDHHEELHAE QMRCKELENA VGSWTDDLTQ LSLLKDTLSA 7750 7760 7770 7780 7790 7800 YISADDISIL NERVELLQRQ WEELCHQLSL RRQQIGERLN EWAVFSEKNK ELCEWLTQME 7810 7820 7830 7840 7850 7860 SKVSQNGDIL IEEMIEKLKK DYQEEIAIAQ ENKIQLQQMG ERLAKASHES KASEIEYKLG 7870 7880 7890 7900 7910 7920 KVNDRWQHLL DLIAARVKKL KETLVAVQQL DKNMSSLRTW LAHIESELAK PIVYDSCNSE 7930 7940 7950 7960 7970 7980 EIQRKLNEQQ ELQRDIEKHS TGVASVLNLC EVLLHDCDAC ATDAECDSIQ QATRNLDRRW 7990 8000 8010 8020 8030 8040 RNICAMSMER RLKIEETWRL WQKFLDDYSR FEDWLKSSER TAAFPSSSGV IYTVAKEELK 8050 8060 8070 8080 8090 8100 KFEAFQRQVH ECLTQLELIN KQYRRLAREN RTDSACSLKQ MVHEGNQRWD NLQKRVTSIL 8110 8120 8130 8140 8150 8160 RRLKHFIGQR EEFETARDSI LVWLTEMDLQ LTNIEHFSEC DVQAKIKQLK AFQQEISLNH 8170 8180 8190 8200 8210 8220 NKIEQIIAQG EQLIEKSEPL DAAIIEEELD ELRRYCQEVF GRVERYHKKL IRLPLPDDEH 8230 8240 8250 8260 8270 8280 DLSDRELELE DSAALSDLHW HDRSADSLLS PQPSSNLSLS LAQPLRSERS GRDTPASVDS 8290 8300 8310 8320 8330 8340 IPLEWDHDYD LSRDLESAMS RALPSEDEEG QDDKDFYLRG AVGLSGDHSA LESQIRQLGK 8350 8360 8370 8380 8390 8400 ALDDSRFQIQ QTENIIRSKT PTGPELDTSY KGYMKLLGEC SSSIDSVKRL EHKLKEEEES 8410 8420 8430 8440 8450 8460 LPGFVNLHST ETQTAGVIDR WELLQAQALS KELRMKQNLQ KWQQFNSDLN SIWAWLGDTE 8470 8480 8490 8500 8510 8520 EELEQLQRLE LSTDIQTIEL QIKKLKELQK AVDHRKAIIL SINLCSPEFT QADSKESRDL 8530 8540 8550 8560 8570 8580 QDRLSQMNGR WDRVCSLLEE WRGLLQDALM QCQGFHEMSH GLLLMLENID RRKNEIVPID 8590 8600 8610 8620 8630 8640 SNLDAEILQD HHKQLMQIKH ELLESQLRVA SLQDMSCQLL VNAEGTDCLE AKEKVHVIGN 8650 8660 8670 8680 8690 8700 RLKLLLKEVS RHIKELEKLL DVSSSQQDLS SWSSADELDT SGSVSPTSGR STPNRQKTPR 8710 8720 8730 8740 8750 8760 GKCSLSQPGP SVSSPHSRST KGGSDSSLSE PGPGRSGRGF LFRVLRAALP LQLLLLLLIG 8770 8780 8790 LACLVPMSEE DYSCALSNNF ARSFHPMLRY TNGPPPL « Hide
Isoform 2 (Beta) [UniParc]. Checksum: DEAC32C9FD296ABD Show »	FASTA	3,321	380,360
10 20 30 40 50 60 MELDAAVQKF LEQNGQLGKP LAKKIGKLTE LHQQTIRQAE NRLSKLNQAA SHLEEYNEML 70 80 90 100 110 120 ELILKWIEKA KVLAHGTIAW NSASQLREQY ILHQTLLEES KEIDSELEAM TEKLQYLTSV 130 140 150 160 170 180 YCTEKMSQQV AELGRETEEL RQMIKIRLQN LQDAAKDMKK FEAELKKLQA ALEQAQATLT 190 200 210 220 230 240 SPEVGRLSLK EQLSHRQHLL SEMESLKPKV QAVQLCQSAL RIPEDVVASL PLCHAALRLQ 250 260 270 280 290 300 EEASRLQHTA IQQCNIMQEA VVQYEQYEQE MKHLQQLIEG AHREIEDKPV ATSNIQELQA 310 320 330 340 350 360 QISRHEELAQ KIKGYQEQIA SLNSKCKMLT MKAKHATMLL TVTEVEGLAE GTEDLDGELL 370 380 390 400 410 420 PTPSAHPSVV MMTAGRCHTL LSPVTEESGE EGTNSEISSP PACRSPSPVA NTDASVNQDI 430 440 450 460 470 480 AYYQALSAER LQTDAAKIHP STSASQEFYE PGLEPSATAK LGDLQRSWET LKNVISEKQR 490 500 510 520 530 540 TLYEALERQQ KYQDSLQSIS TKMEAIELKL SESPEPGRSP ESQMAEHQAL MDEILMLQDE 550 560 570 580 590 600 INELQSSLAE ELVSESCEAD PAEQLALQST LTVLAERMST IRMKASGKRQ LLEEKLNDQL 610 620 630 640 650 660 EEQRQEQALQ RYRCEADELD SWLLSTKATL DTALSPPKEP MDMEAQLMDC QNMLVEIEQK 670 680 690 700 710 720 VVALSELSVH NENLLLEGKA HTKDEAEQLA GKLRRLKGSL LELQRALHDK QLNMQGTAQE 730 740 750 760 770 780 KEESDVDLTA TQSPGVQEWL AQARTTWTQQ RQSSLQQQKE LEQELAEQKS LLRSVASRGE 790 800 810 820 830 840 EILIQHSAAE TSGDAGEKPD VLSQELGMEG EKSSAEDQMR MKWESLHQEF STKQKLLQNV 850 860 870 880 890 900 LEQEQEQVLY SRPNRLLSGV PLYKGDVPTQ DKSAVTSLLD GLNQAFEEVS SQSGGAKRQS 910 920 930 940 950 960 IHLEQKLYDG VSATSTWLDD VEERLFVATA LLPEETETCL FNQEILAKDI KEMSEEMDKN 970 980 990 1000 1010 1020 KNLFSQAFPE NGDNRDVIED TLGCLLGRLS LLDSVVNQRC HQMKERLQQI LNFQNDLKVL 1030 1040 1050 1060 1070 1080 FTSLADNKYI ILQKLANVFE QPVAEQIEAI QQAEDGLKEF DAGIIELKRR GDKLQVEQPS 1090 1100 1110 1120 1130 1140 MQELSKLQDM YDELMMIIGS RRSGLNQNLT LKSQYERALQ DLADLLETGQ EKMAGDQKII 1150 1160 1170 1180 1190 1200 VSSKEEIQQL LDKHKEYFQG LESHMILTET LFRKIISFAV QKETQFHTEL MAQASAVLKR 1210 1220 1230 1240 1250 1260 AHKRGVELEY ILETWSHLDE DQQELSRQLE VVESSIPSVG LVEENEDRLI DRITLYQHLK 1270 1280 1290 1300 1310 1320 SSLNEYQPKL YQVLDDGKRL LISISCSDLE SQLNQLGECW LSNTNKMSKE LHRLETILKH 1330 1340 1350 1360 1370 1380 WTRYQSESAD LIHWLQSAKD RLEFWTQQSV TVPQELEMVR DHLNAFLEFS KEVDAQSSLK 1390 1400 1410 1420 1430 1440 SSVLSTGNQL LRLKKVDTAT LRSELSRIDS QWTDLLTNIP AVQEKLHQLQ MDKLPSRHAI 1450 1460 1470 1480 1490 1500 SEVMSWISLM ENVIQKDEDN IKNSIGYKAI HEYLQKYKGF KIDINCKQLT VDFVNQSVLQ 1510 1520 1530 1540 1550 1560 ISSQDVESKR SDKTDFAEQL GAMNKSWQIL QGLVTEKIQL LEGLLESWSE YENNVQCLKT 1570 1580 1590 1600 1610 1620 WFETQEKRLK QQHRIGDQAS VQNALKDCQD LEDLIKAKEK EVEKIEQNGL ALIQNKKEDV 1630 1640 1650 1660 1670 1680 SSIVMSTLRE LGQTWANLDH MVGQLKILLK SVLDQWSSHK VAFDKINSYL MEARYSLSRF 1690 1700 1710 1720 1730 1740 RLLTGSLEAV QVQVDNLQNL QDDLEKQERS LQKFGSITNQ LLKECHPPVT ETLTNTLKEV 1750 1760 1770 1780 1790 1800 NMRWNNLLEE IAEQLQSSKA LLQLWQRYKD YSKQCASTVQ QQEDRTNELL KAATNKDIAD 1810 1820 1830 1840 1850 1860 DEVATWIQDC NDLLKGLGTV KDSLFFLHEL GEQLKQQVDA SAASAIQSDQ LSLSQHLCAL 1870 1880 1890 1900 1910 1920 EQALCKQQTS LQAGVLDYET FAKSLEALEA WIVEAEEILQ GQDPSHSSDL STIQERMEEL 1930 1940 1950 1960 1970 1980 KGQMLKFSSM APDLDRLNEL GYRLPLNDKE IKRMQNLNRH WSLISSQTTE RFSKLQSFLL 1990 2000 2010 2020 2030 2040 QHQTFLEKCE TWMEFLVQTE QKLAVEISGN YQHLLEQQRA HELFQAEMFS RQQILHSIII 2050 2060 2070 2080 2090 2100 DGQRLLEQGQ VDDRDEFNLK LTLLSNQWQG VIRRAQQRRG IIDSQIRQWQ RYREMAEKLR 2110 2120 2130 2140 2150 2160 KWLVEVSYLP MSGLGSVPIP LQQARTLFDE VQFKEKVFLR QQGSYILTVE AGKQLLLSAD 2170 2180 2190 2200 2210 2220 SGAEAALQAE LAEIQEKWKS ASMRLEEQKK KLAFLLKDWE KCEKGIADSL EKLRTFKKKL 2230 2240 2250 2260 2270 2280 SQSLPDHHEE LHAEQMRCKE LENAVGSWTD DLTQLSLLKD TLSAYISADD ISILNERVEL 2290 2300 2310 2320 2330 2340 LQRQWEELCH QLSLRRQQIG ERLNEWAVFS EKNKELCEWL TQMESKVSQN GDILIEEMIE 2350 2360 2370 2380 2390 2400 KLKKDYQEEI AIAQENKIQL QQMGERLAKA SHESKASEIE YKLGKVNDRW QHLLDLIAAR 2410 2420 2430 2440 2450 2460 VKKLKETLVA VQQLDKNMSS LRTWLAHIES ELAKPIVYDS CNSEEIQRKL NEQQELQRDI 2470 2480 2490 2500 2510 2520 EKHSTGVASV LNLCEVLLHD CDACATDAEC DSIQQATRNL DRRWRNICAM SMERRLKIEE 2530 2540 2550 2560 2570 2580 TWRLWQKFLD DYSRFEDWLK SSERTAAFPS SSGVIYTVAK EELKKFEAFQ RQVHECLTQL 2590 2600 2610 2620 2630 2640 ELINKQYRRL ARENRTDSAC SLKQMVHEGN QRWDNLQKRV TSILRRLKHF IGQREEFETA 2650 2660 2670 2680 2690 2700 RDSILVWLTE MDLQLTNIEH FSECDVQAKI KQLKAFQQEI SLNHNKIEQI IAQGEQLIEK 2710 2720 2730 2740 2750 2760 SEPLDAAIIE EELDELRRYC QEVFGRVERY HKKLIRLPLP DDEHDLSDRE LELEDSAALS 2770 2780 2790 2800 2810 2820 DLHWHDRSAD SLLSPQPSSN LSLSLAQPLR SERSGRDTPA SVDSIPLEWD HDYDLSRDLE 2830 2840 2850 2860 2870 2880 SAMSRALPSE DEEGQDDKDF YLRGAVGLSG DHSALESQIR QLGKALDDSR FQIQQTENII 2890 2900 2910 2920 2930 2940 RSKTPTGPEL DTSYKGYMKL LGECSSSIDS VKRLEHKLKE EEESLPGFVN LHSTETQTAG 2950 2960 2970 2980 2990 3000 VIDRWELLQA QALSKELRMK QNLQKWQQFN SDLNSIWAWL GDTEEELEQL QRLELSTDIQ 3010 3020 3030 3040 3050 3060 TIELQIKKLK ELQKAVDHRK AIILSINLCS PEFTQADSKE SRDLQDRLSQ MNGRWDRVCS 3070 3080 3090 3100 3110 3120 LLEEWRGLLQ DALMQCQGFH EMSHGLLLML ENIDRRKNEI VPIDSNLDAE ILQDHHKQLM 3130 3140 3150 3160 3170 3180 QIKHELLESQ LRVASLQDMS CQLLVNAEGT DCLEAKEKVH VIGNRLKLLL KEVSRHIKEL 3190 3200 3210 3220 3230 3240 EKLLDVSSSQ QDLSSWSSAD ELDTSGSVSP TSGRSTPNRQ KTPRGKCSLS QPGPSVSSPH 3250 3260 3270 3280 3290 3300 SRSTKGGSDS SLSEPGPGRS GRGFLFRVLR AALPLQLLLL LLIGLACLVP MSEEDYSCAL 3310 3320 SNNFARSFHP MLRYTNGPPP L « Hide
Isoform 3 (Alpha) [UniParc]. Checksum: 332A6E5ABA5A2248 Show »	FASTA	982	112,393
10 20 30 40 50 60 MGERLAKASH ESKASEIEYK LGKVNDRWQH LLDLIAARVK KLKETLVAVQ QLDKNMSSLR 70 80 90 100 110 120 TWLAHIESEL AKPIVYDSCN SEEIQRKLNE QQELQRDIEK HSTGVASVLN LCEVLLHDCD 130 140 150 160 170 180 ACATDAECDS IQQATRNLDR RWRNICAMSM ERRLKIEETW RLWQKFLDDY SRFEDWLKSS 190 200 210 220 230 240 ERTAAFPSSS GVIYTVAKEE LKKFEAFQRQ VHECLTQLEL INKQYRRLAR ENRTDSACSL 250 260 270 280 290 300 KQMVHEGNQR WDNLQKRVTS ILRRLKHFIG QREEFETARD SILVWLTEMD LQLTNIEHFS 310 320 330 340 350 360 ECDVQAKIKQ LKAFQQEISL NHNKIEQIIA QGEQLIEKSE PLDAAIIEEE LDELRRYCQE 370 380 390 400 410 420 VFGRVERYHK KLIRLPLPDD EHDLSDRELE LEDSAALSDL HWHDRSADSL LSPQPSSNLS 430 440 450 460 470 480 LSLAQPLRSE RSGRDTPASV DSIPLEWDHD YDLSRDLESA MSRALPSEDE EGQDDKDFYL 490 500 510 520 530 540 RGAVGLSDVM IPESPEAYVK LTENAIKNTS GDHSALESQI RQLGKALDDS RFQIQQTENI 550 560 570 580 590 600 IRSKTPTGPE LDTSYKGYMK LLGECSSSID SVKRLEHKLK EEEESLPGFV NLHSTETQTA 610 620 630 640 650 660 GVIDRWELLQ AQALSKELRM KQNLQKWQQF NSDLNSIWAW LGDTEEELEQ LQRLELSTDI 670 680 690 700 710 720 QTIELQIKKL KELQKAVDHR KAIILSINLC SPEFTQADSK ESRDLQDRLS QMNGRWDRVC 730 740 750 760 770 780 SLLEEWRGLL QDALMQCQGF HEMSHGLLLM LENIDRRKNE IVPIDSNLDA EILQDHHKQL 790 800 810 820 830 840 MQIKHELLES QLRVASLQDM SCQLLVNAEG TDCLEAKEKV HVIGNRLKLL LKEVSRHIKE 850 860 870 880 890 900 LEKLLDVSSS QQDLSSWSSA DELDTSGSVS PTSGRSTPNR QKTPRGKCSL SQPGPSVSSP 910 920 930 940 950 960 HSRSTKGGSD SSLSEPGPGR SGRGFLFRVL RAALPLQLLL LLLIGLACLV PMSEEDYSCA 970 980 LSNNFARSFH PMLRYTNGPP PL « Hide
Isoform 4 [UniParc]. Checksum: 2D846CDD4BC30A8D Show »	FASTA	8,749	1,005,239
10 20 30 40 50 60 MATSRGASRC PRDIANVMQR LQDEQEIVQK RTFTKWINSH LAKRKPPMVV DDLFEDMKDG 70 80 90 100 110 120 VKLLALLEVL SGQKLPCEQG RRMKRIHAVA NIGTALKFLE GRKSMHRGSP IKLVNINSTD 130 140 150 160 170 180 IADGRPSIVL GLMWTIILYF QIEELTSNLP QLQSLSSSAS SVDSIVSSET PSPPSKRKVT 190 200 210 220 230 240 TKIQGNAKKA LLKWVQYTAG KQTGIEVKDF GKSWRSGVAF HSVIHAIRPE LVDLETVKGR 250 260 270 280 290 300 SNRENLEDAF TIAETELGIP RLLDPEDVDV DKPDEKSIMT YVAQFLKHYP DIHNASTDGQ 310 320 330 340 350 360 EDDEILPGFP SFANSVQNFK REDRVIFKEM KVWIEQFERD LTRAQMVESN LQDKYQSFKH 370 380 390 400 410 420 FRVQYEMKRK QIEHLIQPLH RDGKLSLDQA LVKQSWDRVT SRLFDWHIQL DKSLPAPLGT 430 440 450 460 470 480 IGAWLYRAEV ALREEITVQQ VHEETANTIQ RKLEQHKDLL QNTDAHKRAF HEIYRTRSVN 490 500 510 520 530 540 GIPVPPDQLE DMAERFHFVS STSELHLMKM EFLELKYRLL SLLVLAESKL KSWIIKYGRR 550 560 570 580 590 600 ESVEQLLQNY VSFIENSKFF EQYEVTYQIL KQTAEMYVKA DGSVEEAENV MKFMNETTAQ 610 620 630 640 650 660 WRNLSVEVRS VRSMLEEVIS NWDRYGNTVA SLQAWLEDAE KMLNQSENAK KDFFRNLPHW 670 680 690 700 710 720 IQQHTAMNDA GNFLIETCDE MVSRDLKQQL LLLNGRWREL FMEVKQYAQA DEMDRMKKEY 730 740 750 760 770 780 TDCVVTLSAF ATEAHKKLSE PLEVSFMNVK LLIQDLEDIE QRVPVMDAQY KIITKTAHLI 790 800 810 820 830 840 TKESPQEEGK EMFATMSKLK EQLTKVKECY SPLLYESQQL LIPLEELEKQ MTSFYDSLGK 850 860 870 880 890 900 INEIITVLER EAQSSALFKQ KHQELLACQE NCKKTLTLIE KGSQSVQKFV TLSNVLKHFD 910 920 930 940 950 960 QTRLQRQIAD IHVAFQSMVK KTGDWKKHVE TNSRLMKKFE ESRAELEKVL RIAQEGLEEK 970 980 990 1000 1010 1020 GDPEELLRRH TEFFSQLDQR VLNAFLKACD ELTDILPEQE QQGLQEAVRK LHKQWKDLQG 1030 1040 1050 1060 1070 1080 EAPYHLLHLK IDVEKNRFLA SVEECRTELD RETKLMPQEG SEKIIKEHRV FFSDKGPHHL 1090 1100 1110 1120 1130 1140 CEKRLQLIEE LCVKLPVRDP VRDTPGTCHV TLKELRAAID STYRKLMEDP DKWKDYTSRF 1150 1160 1170 1180 1190 1200 SEFSSWISTN ETQLKGIKGE AIDTANHGEV KRAVEEIRNG VTKRGETLSW LKSRLKVLTE 1210 1220 1230 1240 1250 1260 VSSENEAQKQ GDELAKLSSS FKALVTLLSE VEKMLSNFGD CVQYKEIVKN SLEELISGSK 1270 1280 1290 1300 1310 1320 EVQEQAEKIL DTENLFEAQQ LLLHHQQKTK RISAKKRDVQ QQIAQAQQGE GGLPDRGHEE 1330 1340 1350 1360 1370 1380 LRKLESTLDG LERSRERQER RIQVTLRKWE RFETNKETVV RYLFQTGSSH ERFLSFSSLE 1390 1400 1410 1420 1430 1440 SLSSELEQTK EFSKRTESIA VQAENLVKEA SEIPLGPQNK QLLQQQAKSI KEQVKKLEDT 1450 1460 1470 1480 1490 1500 LEEDIKTMEM VKTKWDHFGS NFETLSVWIT EKEKELNALE TSSSAMDMQI SQIKVTIQEI 1510 1520 1530 1540 1550 1560 ESKLSSIVGL EEEAQSFAQF VTTGESARIK AKLTQIRRYG EELREHAQCL EGTILGHLSQ 1570 1580 1590 1600 1610 1620 QQKFEENLRK IQQSVSEFED KLAVPIKICS SATETYKVLQ EHMDLCQALE SLSSAITAFS 1630 1640 1650 1660 1670 1680 ASARKVVNRD SCVQEAAALQ QQYEDILRRA KERQTALENL LAHWQRLEKE LSSFLTWLER 1690 1700 1710 1720 1730 1740 GEAKASSPEM DISADRVKVE GELQLIQALQ NEVVSQASFY SKLLQLKESL FSVASKDDVK 1750 1760 1770 1780 1790 1800 MMKLHLEQLD ERWRDLPQII NKRINFLQSV VAEHQQFDEL LLSFSVWIKL FLSELQTTSE 1810 1820 1830 1840 1850 1860 ISIMDHQVAL TRHKDHAAEV ESKKGELQSL QGHLAKLGSL GRAEDLHLLQ GKAEDCFQLF 1870 1880 1890 1900 1910 1920 EEASQVVERR QLALSHLAEF LQSHASLSGI LRQLRQTVEA TNSMNKNESD LIEKDLNDAL 1930 1940 1950 1960 1970 1980 QNAKALESAA VSLDGILSKA QYHLKIGSSE QRTSCRATAD QLCGEVERIQ NLLGTKQSEA 1990 2000 2010 2020 2030 2040 DALAVLKKAF QDQKEELLKS IEDIEERTDK ERLKEPTRQA LQQRLRVFNQ LEDELNSHEH 2050 2060 2070 2080 2090 2100 ELCWLKDKAK QIAQKDVAFA PEVDREINRL EVTWDDTKRL IHENQGQCCG LIDLMREYQN 2110 2120 2130 2140 2150 2160 LKSAVSKVLE NASSVIVTRT TIKDQEDLKW AFSKHETAKN KMNYKQKDLD NFTSKGKHLL 2170 2180 2190 2200 2210 2220 SELKKIHSSD FSLVKTDMES TVDKWLDVSE KLEENMDRLR VSLSIWDDVL STRDEIEGWS 2230 2240 2250 2260 2270 2280 NNCVPQMAEN ISNLDNHLRA EELLKEFESE VKNKALRLEE LHSKVNDLKE LTKNLETPPD 2290 2300 2310 2320 2330 2340 LQFIEADLMQ KLEHAKEITE VAKGTLKDFT AQSTQVEKFI NDITTWFTKV EESLMNCAQN 2350 2360 2370 2380 2390 2400 ETCEALKKVK DIQKELQSQQ SNISSTQENL NSLCRKYHSA ELESLGRAMT GLIKKHEAVS 2410 2420 2430 2440 2450 2460 QLCSKTQASL QESLEKHFSE SMQEFQEWFL GAKAAAKESS DRTGDSKVLE AKLHDLQNIL 2470 2480 2490 2500 2510 2520 DSVSDGQSKL DAVTQEGQTL YAHLSKQIVS SIQEQITKAN EEFQAFLKQC LKDKQALQDC 2530 2540 2550 2560 2570 2580 ASELGSFEDQ HRKLNLWIHE MEERFNTENL GESKQHIPEK KNEVHKVEMF LGELLAARES 2590 2600 2610 2620 2630 2640 LDKLSQRGQL LSEEGHGAGQ EGRLCSQLLT SHQNLLRMTK EKLRSCQVAL QEHEALEEAL 2650 2660 2670 2680 2690 2700 QSMWFWVKAI QDRLACAEST LGSKDTLEKR LSQIQDILLM KGEGEVKLNM AIGKGEQALR 2710 2720 2730 2740 2750 2760 SSNKEGQRVI QTQLETLKEV WADIMSSSVH AQSTLESVIS QWNDYVERKN QLEQWMESVD 2770 2780 2790 2800 2810 2820 QKIEHPLQPQ PGLKEKFVLL DHLQSILSEA EDHTRALHRL IAKSRELYEK TEDESFKDTA 2830 2840 2850 2860 2870 2880 QEELKTQFND IMTVAKEKMR KVEEIVKDHL MYLDAVHEFT DWLHSAKEEL HRWSDMSGDS 2890 2900 2910 2920 2930 2940 SATQKKLSKI KELIDSREIG ASRLSRVESL APEVKQNTTA SGCELMHTEM QALRADWKQW 2950 2960 2970 2980 2990 3000 EDSVFQTQSC LENLVSQMAL SEQEFSGQVA QLEQALEQFS ALLKTWAQQL TLLEGKNTDE 3010 3020 3030 3040 3050 3060 EIVECWHKGQ EILDALQKAE PRTEDLKSQL NELCRFSRDL STYSGKVSGL IKEYNCLCLQ 3070 3080 3090 3100 3110 3120 ASKGCQNKEQ ILQQRFRKAF RDFQQWLVNA KITTAKCFDI PQNISEVSTS LQKIQEFLSE 3130 3140 3150 3160 3170 3180 SENGQHKLNM MLSKGELLST LLTKEKAKGI QAKVTAAKED WKNFHSNLHQ KESALENLKI 3190 3200 3210 3220 3230 3240 QMKDFEVSAE PIQDWLSKTE KMVHESSNRL YDLPAKRREQ QKLQSVLEEI HCYEPQLNRL 3250 3260 3270 3280 3290 3300 KEKAQQLWEG QAASKSFRHR VSQLSSQYLA LSNLTKEKVS RLDRIVAEHN QFSLGIKELQ 3310 3320 3330 3340 3350 3360 DWMTDAIHML DSYCHPTSDK SVLDSRTLKL EALLSVKQEK EIQMKMIVTR GESVLQNTSP 3370 3380 3390 3400 3410 3420 EGIPTIQQQL QSVKDMWASL LSAGIRCKSQ LEGALSKWTS YQDGVRQFSG WMDSMEANLN 3430 3440 3450 3460 3470 3480 ESERQHAELR DKTTMLGKAK LLNEEVLSYS SLLETIEVKG AGMTEHYVTQ LELQDLQERY 3490 3500 3510 3520 3530 3540 RAIQERAKEA VTKSEKLVRL HQEYQRDLKA FEVWLGQEQE KLDQYSVLEG DAHTHETTLR 3550 3560 3570 3580 3590 3600 DLQELQVHCA EGQALLNSVL HTREDVIPSG IPQAEDRALE SLRQDWQAYQ HRLSETRTQF 3610 3620 3630 3640 3650 3660 NNVVNKLRLM EQKFQQVDEW LKTAEEKKWH EEVTAYRDEV EEVGARAQEI LDESHVNSRM 3670 3680 3690 3700 3710 3720 GCQATQLTSR YQALLLQVLE QIKFLEEEIQ SLEESESSLS SYSDWYGSTH KNFKNVATKI 3730 3740 3750 3760 3770 3780 DKVDTVMMGK KLKTLEVLLK DMEKGHSLLK SAREKGERAV KYLEEGEAER LRKEIHDHME 3790 3800 3810 3820 3830 3840 QLKELTSTVR KEHMTLEKGL HLAKEFSDKC KALTQWIAEY QEILHVPEEP KMELYEKKAQ 3850 3860 3870 3880 3890 3900 LSKYKSLQQT VLSHEPSVKS VREKGEALLE LVQDVTLKDK IDQLQSDYQD LCSIGKAMME 3910 3920 3930 3940 3950 3960 EIAGFEDRLN NLQMKGDTLI GQCADHLQAK LKQNVHAHLQ GTKDSYSAIC STAQRMYQSL 3970 3980 3990 4000 4010 4020 EHELQKHVSR QDTLQQCQAW LSAVQPDLEP SPQPPLSRAE AIKQVKHFRA LQEQARTYLD 4030 4040 4050 4060 4070 4080 LLCSMCDLSN ASVKTTAKDI QQTEQTIEQK LVQAQNLTQG WEEIKHLKSE LWIYLQDADQ 4090 4100 4110 4120 4130 4140 QLQNMKRRHS ELELNIAQNM VSQVKDFVKK LQSKQASVNT IIEKVNKLTK KEESPEHKEI 4150 4160 4170 4180 4190 4200 NHLNDQWLDL CRQSNNLCLQ REEDLQRTRD YHDCMNVVEV FLEKFTTEWD NLARSDAEST 4210 4220 4230 4240 4250 4260 AVHLEALKKL ALALQERKYA IEDLKDQKQK MIEHLNLDDK ELVKEQTSHL EQRWFQLEDL 4270 4280 4290 4300 4310 4320 IKRKIQVSVT NLEELNVVQS RFQELMEWAE EQQPNIAEAL KQSPPPDMAQ NLLMDHLAIC 4330 4340 4350 4360 4370 4380 SELEAKQMLL KSLIKDADRV MADLGLNERQ VIQKALSDAQ SHVNCLSDLV GQRRKYLNKA 4390 4400 4410 4420 4430 4440 LSEKTQFLMA VFQATSQIQQ HERKIMFREH ICLLPDDVSK QVKTCKSAQA SLKTYQNEVT 4450 4460 4470 4480 4490 4500 GLWAQGRELM KEVTEQEKSE VLGKLQELQS VYDSVLQKCS HRLQELEKNL VSRKHFKEDF 4510 4520 4530 4540 4550 4560 DKACHWLKQA DIVTFPEINL MNESSELHTQ LAKYQNILEQ SPEYENLLLT LQRTGQTILP 4570 4580 4590 4600 4610 4620 SLNEVDHSYL SEKLNALPRQ FNVIVALAKD KFYKVQEAIL ARKEYASLIE LTTQSLSELE 4630 4640 4650 4660 4670 4680 AQFLRMSKVP TDLAVEEALS LQDGCRAILD EVAGLGEAVD ELNQKKEGFR STGQPWQPDK 4690 4700 4710 4720 4730 4740 MLHLVTLYHR LKRQTEQRVS LLEDTTSAYQ EHEKMCQQLE RQLKSVKEEQ SKVNEETLPA 4750 4760 4770 4780 4790 4800 EEKLKMYHSL AGSLQDSGIV LKRVTIHLED LAPHLDPLAY EKARHQIQSW QGELKLLTSA 4810 4820 4830 4840 4850 4860 IGETVTECES RMVQSIDFQT EMSRSLDWLR RVKAELSGPV YLDLNLQDIQ EEIRKIQIHQ 4870 4880 4890 4900 4910 4920 EEVQSSLRIM NALSHKEKEK FTKAKELISA DLEHSLAELS ELDGDIQEAL RTRQATLTEI 4930 4940 4950 4960 4970 4980 YSQCQRYYQV FQAANDWLED AQELLQLAGN GLDVESAEEN LKSHMEFFST EDQFHSNLEE 4990 5000 5010 5020 5030 5040 LHSLVATLDP LIKPTGKEDL EQKVASLELR SQRMSRDSGA QVDLLQRCTA QWHDYQKARE 5050 5060 5070 5080 5090 5100 EVIELMNDTE KKLSEFSLLK TSSSHEAEEK LSEHKALVSV VNSFHEKIVA LEEKASQLEK 5110 5120 5130 5140 5150 5160 TGNDASKATL SRSMTTVWQR WTRLRAVAQD QEKILEDAVD EWTGFNNKVK KATEMIDQLQ 5170 5180 5190 5200 5210 5220 DKLPGSSAEK ASKAELLTLL EYHDTFVLEL EQQQSALGML RQQTLSMLQD GAAPTPGEEP 5230 5240 5250 5260 5270 5280 PLMQEITAMQ DRCLNMQEKV KTNGKLVKQE LKDREMVETQ INSVKCWVQE TKEYLGNPTI 5290 5300 5310 5320 5330 5340 EIDAQLEELQ ILLTEATNHR QNIEKMAEEQ KEKYLGLYTI LPSELSLQLA EVALDLKIRD 5350 5360 5370 5380 5390 5400 QIQDKIKEVE QSKATSQELS RQIQKLAKDL TTILTKLKAK TDNVVQAKTD QKVLGEELDG 5410 5420 5430 5440 5450 5460 CNSKLMELDA AVQKFLEQNG QLGKPLAKKI GKLTELHQQT IRQAENRLSK LNQAASHLEE 5470 5480 5490 5500 5510 5520 YNEMLELILK WIEKAKVLAH GTIAWNSASQ LREQYILHQT LLEESKEIDS ELEAMTEKLQ 5530 5540 5550 5560 5570 5580 YLTSVYCTEK MSQQVAELGR ETEELRQMIK IRLQNLQDAA KDMKKFEAEL KKLQAALEQA 5590 5600 5610 5620 5630 5640 QATLTSPEVG RLSLKEQLSH RQHLLSEMES LKPKVQAVQL CQSALRIPED VVASLPLCHA 5650 5660 5670 5680 5690 5700 ALRLQEEASR LQHTAIQQCN IMQEAVVQYE QYEQEMKHLQ QLIEGAHREI EDKPVATSNI 5710 5720 5730 5740 5750 5760 QELQAQISRH EELAQKIKGY QEQIASLNSK CKMLTMKAKH ATMLLTVTEV EGLAEGTEDL 5770 5780 5790 5800 5810 5820 DGELLPTPSA HPSVVMMTAG RCHTLLSPVT EESGEEGTNS EISSPPACRS PSPVANTDAS 5830 5840 5850 5860 5870 5880 VNQDIAYYQA LSAERLQTDA AKIHPSTSAS QEFYEPGLEP SATAKLGDLQ RSWETLKNVI 5890 5900 5910 5920 5930 5940 SEKQRTLYEA LERQQKYQDS LQSISTKMEA IELKLSESPE PGRSPESQMA EHQALMDEIL 5950 5960 5970 5980 5990 6000 MLQDEINELQ SSLAEELVSE SCEADPAEQL ALQSTLTVLA ERMSTIRMKA SGKRQLLEEK 6010 6020 6030 6040 6050 6060 LNDQLEEQRQ EQALQRYRCE ADELDSWLLS TKATLDTALS PPKEPMDMEA QLMDCQNMLV 6070 6080 6090 6100 6110 6120 EIEQKVVALS ELSVHNENLL LEGKAHTKDE AEQLAGKLRR LKGSLLELQR ALHDKQLNMQ 6130 6140 6150 6160 6170 6180 GTAQEKEESD VDLTATQSPG VQEWLAQART TWTQQRQSSL QQQKELEQEL AEQKSLLRSV 6190 6200 6210 6220 6230 6240 ASRGEEILIQ HSAAETSGDA GEKPDVLSQE LGMEGEKSSA EDQMRMKWES LHQEFSTKQK 6250 6260 6270 6280 6290 6300 LLQNVLEQEQ EQVLYSRPNR LLSGVPLYKG DVPTQDKSAV TSLLDGLNQA FEEVSSQSGG 6310 6320 6330 6340 6350 6360 AKRQSIHLEQ KLYDGVSATS TWLDDVEERL FVATALLPEE TETCLFNQEI LAKDIKEMSE 6370 6380 6390 6400 6410 6420 EMDKNKNLFS QAFPENGDNR DVIEDTLGCL LGRLSLLDSV VNQRCHQMKE RLQQILNFQN 6430 6440 6450 6460 6470 6480 DLKVLFTSLA DNKYIILQKL ANVFEQPVAE QIEAIQQAED GLKEFDAGII ELKRRGDKLQ 6490 6500 6510 6520 6530 6540 VEQPSMQELS KLQDMYDELM MIIGSRRSGL NQNLTLKSQY ERALQDLADL LETGQEKMAG 6550 6560 6570 6580 6590 6600 DQKIIVSSKE EIQQLLDKHK EYFQGLESHM ILTETLFRKI ISFAVQKETQ FHTELMAQAS 6610 6620 6630 6640 6650 6660 AVLKRAHKRG VELEYILETW SHLDEDQQEL SRQLEVVESS IPSVGLVEEN EDRLIDRITL 6670 6680 6690 6700 6710 6720 YQHLKSSLNE YQPKLYQVLD DGKRLLISIS CSDLESQLNQ LGECWLSNTN KMSKELHRLE 6730 6740 6750 6760 6770 6780 TILKHWTRYQ SESADLIHWL QSAKDRLEFW TQQSVTVPQE LEMVRDHLNA FLEFSKEVDA 6790 6800 6810 6820 6830 6840 QSSLKSSVLS TGNQLLRLKK VDTATLRSEL SRIDSQWTDL LTNIPAVQEK LHQLQMDKLP 6850 6860 6870 6880 6890 6900 SRHAISEVMS WISLMENVIQ KDEDNIKNSI GYKAIHEYLQ KYKGFKIDIN CKQLTVDFVN 6910 6920 6930 6940 6950 6960 QSVLQISSQD VESKRSDKTD FAEQLGAMNK SWQILQGLVT EKIQLLEGLL ESWSEYENNV 6970 6980 6990 7000 7010 7020 QCLKTWFETQ EKRLKQQHRI GDQASVQNAL KDCQDLEDLI KAKEKEVEKI EQNGLALIQN 7030 7040 7050 7060 7070 7080 KKEDVSSIVM STLRELGQTW ANLDHMVGQL KILLKSVLDQ WSSHKVAFDK INSYLMEARY 7090 7100 7110 7120 7130 7140 SLSRFRLLTG SLEAVQVQVD NLQNLQDDLE KQERSLQKFG SITNQLLKEC HPPVTETLTN 7150 7160 7170 7180 7190 7200 TLKEVNMRWN NLLEEIAEQL QSSKALLQLW QRYKDYSKQC ASTVQQQEDR TNELLKAATN 7210 7220 7230 7240 7250 7260 KDIADDEVAT WIQDCNDLLK GLGTVKDSLF FLHELGEQLK QQVDASAASA IQSDQLSLSQ 7270 7280 7290 7300 7310 7320 HLCALEQALC KQQTSLQAGV LDYETFAKSL EALEAWIVEA EEILQGQDPS HSSDLSTIQE 7330 7340 7350 7360 7370 7380 RMEELKGQML KFSSMAPDLD RLNELGYRLP LNDKEIKRMQ NLNRHWSLIS SQTTERFSKL 7390 7400 7410 7420 7430 7440 QSFLLQHQTF LEKCETWMEF LVQTEQKLAV EISGNYQHLL EQQRAHELFQ AEMFSRQQIL 7450 7460 7470 7480 7490 7500 HSIIIDGQRL LEQGQVDDRD EFNLKLTLLS NQWQGVIRRA QQRRGIIDSQ IRQWQRYREM 7510 7520 7530 7540 7550 7560 AEKLRKWLVE VSYLPMSGLG SVPIPLQQAR TLFDEVQFKE KVFLRQQGSY ILTVEAGKQL 7570 7580 7590 7600 7610 7620 LLSADSGAEA ALQAELAEIQ EKWKSASMRL EEQKKKLAFL LKDWEKCEKG IADSLEKLRT 7630 7640 7650 7660 7670 7680 FKKKLSQSLP DHHEELHAEQ MRCKELENAV GSWTDDLTQL SLLKDTLSAY ISADDISILN 7690 7700 7710 7720 7730 7740 ERVELLQRQW EELCHQLSLR RQQIGERLNE WAVFSEKNKE LCEWLTQMES KVSQNGDILI 7750 7760 7770 7780 7790 7800 EEMIEKLKKD YQEEIAIAQE NKIQLQQMGE RLAKASHESK ASEIEYKLGK VNDRWQHLLD 7810 7820 7830 7840 7850 7860 LIAARVKKLK ETLVAVQQLD KNMSSLRTWL AHIESELAKP IVYDSCNSEE IQRKLNEQQE 7870 7880 7890 7900 7910 7920 LQRDIEKHST GVASVLNLCE VLLHDCDACA TDAECDSIQQ ATRNLDRRWR NICAMSMERR 7930 7940 7950 7960 7970 7980 LKIEETWRLW QKFLDDYSRF EDWLKSSERT AAFPSSSGVI YTVAKEELKK FEAFQRQVHE 7990 8000 8010 8020 8030 8040 CLTQLELINK QYRRLARENR TDSACSLKQM VHEGNQRWDN LQKRVTSILR RLKHFIGQRE 8050 8060 8070 8080 8090 8100 EFETARDSIL VWLTEMDLQL TNIEHFSECD VQAKIKQLKA FQQEISLNHN KIEQIIAQGE 8110 8120 8130 8140 8150 8160 QLIEKSEPLD AAIIEEELDE LRRYCQEVFG RVERYHKKLI RLPLPDDEHD LSDRELELED 8170 8180 8190 8200 8210 8220 SAALSDLHWH DRSADSLLSP QPSSNLSLSL AQPLRSERSG RDTPASVDSI PLEWDHDYDL 8230 8240 8250 8260 8270 8280 SRDLESAMSR ALPSEDEEGQ DDKDFYLRGA VGLSDVMIPE SPEAYVKLTE NAIKNTSGDH 8290 8300 8310 8320 8330 8340 SALESQIRQL GKALDDSRFQ IQQTENIIRS KTPTGPELDT SYKGYMKLLG ECSSSIDSVK 8350 8360 8370 8380 8390 8400 RLEHKLKEEE ESLPGFVNLH STETQTAGVI DRWELLQAQA LSKELRMKQN LQKWQQFNSD 8410 8420 8430 8440 8450 8460 LNSIWAWLGD TEEELEQLQR LELSTDIQTI ELQIKKLKEL QKAVDHRKAI ILSINLCSPE 8470 8480 8490 8500 8510 8520 FTQADSKESR DLQDRLSQMN GRWDRVCSLL EEWRGLLQDA LMQCQGFHEM SHGLLLMLEN 8530 8540 8550 8560 8570 8580 IDRRKNEIVP IDSNLDAEIL QDHHKQLMQI KHELLESQLR VASLQDMSCQ LLVNAEGTDC 8590 8600 8610 8620 8630 8640 LEAKEKVHVI GNRLKLLLKE VSRHIKELEK LLDVSSSQQD LSSWSSADEL DTSGSVSPTS 8650 8660 8670 8680 8690 8700 GRSTPNRQKT PRGKCSLSQP GPSVSSPHSR STKGGSDSSL SEPGPGRSGR GFLFRVLRAA 8710 8720 8730 8740 LPLQLLLLLL IGLACLVPMS EEDYSCALSN NFARSFHPML RYTNGPPPL « Hide
Isoform 5 [UniParc]. Checksum: 01D6C47A6D74C395 Show »	FASTA	1,443	167,250
10 20 30 40 50 60 MATSRGASRC PRDIANVMQR LQDEQEIVQK RTFTKWINSH LAKRKPPMVV DDLFEDMKDG 70 80 90 100 110 120 VKLLALLEVL SGQKLPCEQG RRMKRIHAVA NIGTALKFLE GRKIKLVNIN STDIADGRPS 130 140 150 160 170 180 IVLGLMWTII LYFQIEELTS NLPQLQSLSS SASSVDSIVS SETPSPPSKR KVTTKIQGNA 190 200 210 220 230 240 KKALLKWVQY TAGKQTGIEV KDFGKSWRSG VAFHSVIHAI RPELVDLETV KGRSNRENLE 250 260 270 280 290 300 DAFTIAETEL GIPRLLDPED VDVDKPDEKS IMTYVAQFLK HYPDIHNAST DGQEDDEILP 310 320 330 340 350 360 GFPSFANSVQ NFKREDRVIF KEMKVWIEQF ERDLTRAQMV ESNLQDKYQS FKHFRVQYEM 370 380 390 400 410 420 KRKQIEHLIQ PLHRDGKLSL DQALVKQSWD RVTSRLFDWH IQLDKSLPAP LGTIGAWLYR 430 440 450 460 470 480 AEVALREEIT VQQVHEETAN TIQRKLEQHK DLLQNTDAHK RAFHEIYRTR SVNGIPVPPD 490 500 510 520 530 540 QLEDMAERFH FVSSTSELHL MKMEFLELKY RLLSLLVLAE SKLKSWIIKY GRRESVEQLL 550 560 570 580 590 600 QNYVSFIENS KFFEQYEVTY QILKQTAEMY VKADGSVEEA ENVMKFMNET TAQWRNLSVE 610 620 630 640 650 660 VRSVRSMLEE VISNWDRYGN TVASLQAWLE DAEKMLNQSE NAKKDFFRNL PHWIQQHTAM 670 680 690 700 710 720 NDAGNFLIET CDEMVSRDLK QQLLLLNGRW RELFMEVKQY AQADEMDRMK KEYTDCVVTL 730 740 750 760 770 780 SAFATEAHKK LSEPLEVSFM NVKLLIQDLE DIEQRVPVMD AQYKIITKTA HLITKESPQE 790 800 810 820 830 840 EGKEMFATMS KLKEQLTKVK ECYSPLLYES QQLLIPLEEL EKQMTSFYDS LGKINEIITV 850 860 870 880 890 900 LEREAQSSAL FKQKHQELLA CQENCKKTLT LIEKGSQSVQ KFVTLSNVLK HFDQTRLQRQ 910 920 930 940 950 960 IADIHVAFQS MVKKTGDWKK HVETNSRLMK KFEESRAELE KVLRIAQEGL EEKGDPEELL 970 980 990 1000 1010 1020 RRHTEFFSQL DQRVLNAFLK ACDELTDILP EQEQQGLQEA VRKLHKQWKD LQGEAPYHLL 1030 1040 1050 1060 1070 1080 HLKIDVEKNR FLASVEECRT ELDRETKLMP QEGSEKIIKE HRVFFSDKGP HHLCEKRLQL 1090 1100 1110 1120 1130 1140 IEELCVKLPV RDPVRDTPGT CHVTLKELRA AIDSTYRKLM EDPDKWKDYT SRFSEFSSWI 1150 1160 1170 1180 1190 1200 STNETQLKGI KGEAIDTANH GEVKRAVEEI RNGVTKRGET LSWLKSRLKV LTEVSSENEA 1210 1220 1230 1240 1250 1260 QKQGDELAKL SSSFKALVTL LSEVEKMLSN FGDCVQYKEI VKNSLEELIS GSKEVQEQAE 1270 1280 1290 1300 1310 1320 KILDTENLFE AQQLLLHHQQ KTKRISAKKR DVQQQIAQAQ QGEGGLPDRG HEELRKLEST 1330 1340 1350 1360 1370 1380 LDGLERSRER QERRIQVTLR KWERFETNKE TVVRYLFQTG SSHERFLSFS SLESLSSELE 1390 1400 1410 1420 1430 1440 QTKEFSKRTE SIAVQAENLV KEASEIPLGP QNKQLLQQQA KSIKEQVKKL EDTLEEEYVI DKS « Hide
Isoform 6 [UniParc]. Checksum: 1ED934CA22A45E49 Show »	FASTA	1,725	199,267
10 20 30 40 50 60 MATSRGASRC PRDIANVMQR LQDEQEIVQK RTFTKWINSH LAKRKPPMVV DDLFEDMKDG 70 80 90 100 110 120 VKLLALLEVL SGQKLPCEQG RRMKRIHAVA NIGTALKFLE GRKIKLVNIN STDIADGRPS 130 140 150 160 170 180 IVLGLMWTII LYFQIEELTS NLPQLQSLSS SASSVDSIVS SETPSPPSKR KVTTKIQGNA 190 200 210 220 230 240 KKALLKWVQY TAGKQTGIEV KDFGKSWRSG VAFHSVIHAI RPELVDLETV KGRSNRENLE 250 260 270 280 290 300 DAFTIAETEL GIPRLLDPED VDVDKPDEKS IMTYVAQFLK HYPDIHNAST DGQEDDEILP 310 320 330 340 350 360 GFPSFANSVQ NFKREDRVIF KEMKVWIEQF ERDLTRAQMV ESNLQDKYQS FKHFRVQYEM 370 380 390 400 410 420 KRKQIEHLIQ PLHRDGKLSL DQALVKQSWD RVTSRLFDWH IQLDKSLPAP LGTIGAWLYR 430 440 450 460 470 480 AEVALREEIT VQQVHEETAN TIQRKLEQHK DLLQNTDAHK RAFHEIYRTR SVNGIPVPPD 490 500 510 520 530 540 QLEDMAERFH FVSSTSELHL MKMEFLELKY RLLSLLVLAE SKLKSWIIKY GRRESVEQLL 550 560 570 580 590 600 QNYVSFIENS KFFEQYEVTY QILKQTAEMY VKADGSVEEA ENVMKFMNET TAQWRNLSVE 610 620 630 640 650 660 VRSVRSMLEE VISNWDRYGN TVASLQAWLE DAEKMLNQSE NAKKDFFRNL PHWIQQHTAM 670 680 690 700 710 720 NDAGNFLIET CDEMVSRDLK QQLLLLNGRW RELFMEVKQY AQADEMDRMK KEYTDCVVTL 730 740 750 760 770 780 SAFATEAHKK LSEPLEVSFM NVKLLIQDLE DIEQRVPVMD AQYKIITKTA HLITKESPQE 790 800 810 820 830 840 EGKEMFATMS KLKEQLTKVK ECYSPLLYES QQLLIPLEEL EKQMTSFYDS LGKINEIITV 850 860 870 880 890 900 LEREAQSSAL FKQKHQELLA CQENCKKTLT LIEKGSQSVQ KFVTLSNVLK HFDQTRLQRQ 910 920 930 940 950 960 IADIHVAFQS MVKKTGDWKK HVETNSRLMK KFEESRAELE KVLRIAQEGL EEKGDPEELL 970 980 990 1000 1010 1020 RRHTEFFSQL DQRVLNAFLK ACDELTDILP EQEQQGLQEA VRKLHKQWKD LQGEAPYHLL 1030 1040 1050 1060 1070 1080 HLKIDVEKNR FLASVEECRT ELDRETKLMP QEGSEKIIKE HRVFFSDKGP HHLCEKRLQL 1090 1100 1110 1120 1130 1140 IEELCVKLPV RDPVRDTPGT CHVTLKELRA AIDSTYRKLM EDPDKWKDYT SRFSEFSSWI 1150 1160 1170 1180 1190 1200 STNETQLKGI KGEAIDTANH GEVKRAVEEI RNGVTKRGET LSWLKSRLKV LTEVSSENEA 1210 1220 1230 1240 1250 1260 QKQGDELAKL SSSFKALVTL LSEVEKMLSN FGDCVQYKEI VKNSLEELIS GSKEVQEQAE 1270 1280 1290 1300 1310 1320 KILDTENLFE AQQLLLHHQQ KTKRISAKKR DVQQQIAQAQ QGEGGLPDRG HEELRKLEST 1330 1340 1350 1360 1370 1380 LDGLERSRER QERRIQVTLR KWERFETNKE TVVRYLFQTG SSHERFLSFS SLESLSSELE 1390 1400 1410 1420 1430 1440 QTKEFSKRTE SIAVQAENLV KEASEIPLGP QNKQLLQQQA KSIKEQVKKL EDTLEEDIKT 1450 1460 1470 1480 1490 1500 MEMVKTKWDH FGSNFETLSV WITEKEKELN ALETSSSAMD MQISQIKVTI QEIESKLSSI 1510 1520 1530 1540 1550 1560 VGLEEEAQSF AQFVTTGESA RIKAKLTQIR RYGEELREHA QCLEGTILGH LSQQQKFEEN 1570 1580 1590 1600 1610 1620 LRKIQQSVSE FEDKLAVPIK ICSSATETYK VLQEHMDLCQ ALESLSSAIT AFSASARKVV 1630 1640 1650 1660 1670 1680 NRDSCVQEAA ALQQQYEDIL RRAKERQTAL ENLLAHWQRL EKELSSFLTW LERGEAKASS 1690 1700 1710 1720 PEMDISADRV KVEGELQLIQ ASSRKCEEGK NKMLFVTVTL FKIIK « Hide
Isoform 7 [UniParc]. Checksum: EEDEA59F5A4DBD2A Show »	FASTA	5,580	642,672
10 20 30 40 50 60 MATSRGASRC PRDIANVMQR LQDEQEIVQK RTFTKWINSH LAKRKPPMVV DDLFEDMKDG 70 80 90 100 110 120 VKLLALLEVL SGQKLPCEQG RRMKRIHAVA NIGTALKFLE GRKIKLVNIN STDIADGRPS 130 140 150 160 170 180 IVLGLMWTII LYFQIEELTS NLPQLQSLSS SASSVDSIVS SETPSPPSKR KVTTKIQGNA 190 200 210 220 230 240 KKALLKWVQY TAGKQTGIEV KDFGKSWRSG VAFHSVIHAI RPELVDLETV KGRSNRENLE 250 260 270 280 290 300 DAFTIAETEL GIPRLLDPED VDVDKPDEKS IMTYVAQFLK HYPDIHNAST DGQEDDEILP 310 320 330 340 350 360 GFPSFANSVQ NFKREDRVIF KEMKVWIEQF ERDLTRAQMV ESNLQDKYQS FKHFRVQYEM 370 380 390 400 410 420 KRKQIEHLIQ PLHRDGKLSL DQALVKQSWD RVTSRLFDWH IQLDKSLPAP LGTIGAWLYR 430 440 450 460 470 480 AEVALREEIT VQQVHEETAN TIQRKLEQHK DLLQNTDAHK RAFHEIYRTR SVNGIPVPPD 490 500 510 520 530 540 QLEDMAERFH FVSSTSELHL MKMEFLELKY RLLSLLVLAE SKLKSWIIKY GRRESVEQLL 550 560 570 580 590 600 QNYVSFIENS KFFEQYEVTY QILKQTAEMY VKADGSVEEA ENVMKFMNET TAQWRNLSVE 610 620 630 640 650 660 VRSVRSMLEE VISNWDRYGN TVASLQAWLE DAEKMLNQSE NAKKDFFRNL PHWIQQHTAM 670 680 690 700 710 720 NDAGNFLIET CDEMVSRDLK QQLLLLNGRW RELFMEVKQY AQADEMDRMK KEYTDCVVTL 730 740 750 760 770 780 SAFATEAHKK LSEPLEVSFM NVKLLIQDLE DIEQRVPVMD AQYKIITKTA HLITKESPQE 790 800 810 820 830 840 EGKEMFATMS KLKEQLTKVK ECYSPLLYES QQLLIPLEEL EKQMTSFYDS LGKINEIITV 850 860 870 880 890 900 LEREAQSSAL FKQKHQELLA CQENCKKTLT LIEKGSQSVQ KFVTLSNVLK HFDQTRLQRQ 910 920 930 940 950 960 IADIHVAFQS MVKKTGDWKK HVETNSRLMK KFEESRAELE KVLRIAQEGL EEKGDPEELL 970 980 990 1000 1010 1020 RRHTEFFSQL DQRVLNAFLK ACDELTDILP EQEQQGLQEA VRKLHKQWKD LQGEAPYHLL 1030 1040 1050 1060 1070 1080 HLKIDVEKNR FLASVEECRT ELDRETKLMP QEGSEKIIKE HRVFFSDKGP HHLCEKRLQL 1090 1100 1110 1120 1130 1140 IEELCVKLPV RDPVRDTPGT CHVTLKELRA AIDSTYRKLM EDPDKWKDYT SRFSEFSSWI 1150 1160 1170 1180 1190 1200 STNETQLKGI KGEAIDTANH GEVKRAVEEI RNGVTKRGET LSWLKSRLKV LTEVSSENEA 1210 1220 1230 1240 1250 1260 QKQGDELAKL SSSFKALVTL LSEVEKMLSN FGDCVQYKEI VKNSLEELIS GSKEVQEQAE 1270 1280 1290 1300 1310 1320 KILDTENLFE AQQLLLHHQQ KTKRISAKKR DVQQQIAQAQ QGEGGLPDRG HEELRKLEST 1330 1340 1350 1360 1370 1380 LDGLERSRER QERRIQVTLR KWERFETNKE TVVRYLFQTG SSHERFLSFS SLESLSSELE 1390 1400 1410 1420 1430 1440 QTKEFSKRTE SIAVQAENLV KEASEIPLGP QNKQLLQQQA KSIKEQVKKL EDTLEEDIKT 1450 1460 1470 1480 1490 1500 MEMVKTKWDH FGSNFETLSV WITEKEKELN ALETSSSAMD MQISQIKVTI QEIESKLSSI 1510 1520 1530 1540 1550 1560 VGLEEEAQSF AQFVTTGESA RIKAKLTQIR RYGEELREHA QCLEGTILGH LSQQQKFEEN 1570 1580 1590 1600 1610 1620 LRKIQQSVSE FEDKLAVPIK ICSSATETYK VLQEHMDLCQ ALESLSSAIT AFSASARKVV 1630 1640 1650 1660 1670 1680 NRDSCVQEAA ALQQQYEDIL RRAKERQTAL ENLLAHWQRL EKELSSFLTW LERGEAKASS 1690 1700 1710 1720 1730 1740 PEMDISADRV KVEGELQLIQ ALQNEVVSQA SFYSKLLQLK ESLFSVASKD DVKMMKLHLE 1750 1760 1770 1780 1790 1800 QLDERWRDLP QIINKRINFL QSVVAEHQQF DELLLSFSVW IKLFLSELQT TSEISIMDHQ 1810 1820 1830 1840 1850 1860 VALTRHKDHA AEVESKKGEL QSLQGHLAKL GSLGRAEDLH LLQGKAEDCF QLFEEASQVV 1870 1880 1890 1900 1910 1920 ERRQLALSHL AEFLQSHASL SGILRQLRQT VEATNSMNKN ESDLIEKDLN DALQNAKALE 1930 1940 1950 1960 1970 1980 SAAVSLDGIL SKAQYHLKIG SSEQRTSCRA TADQLCGEVE RIQNLLGTKQ SEADALAVLK 1990 2000 2010 2020 2030 2040 KAFQDQKEEL LKSIEDIEER TDKERLKEPT RQALQQRLRV FNQLEDELNS HEHELCWLKD 2050 2060 2070 2080 2090 2100 KAKQIAQKDV AFAPEVDREI NRLEVTWDDT KRLIHENQGQ CCGLIDLMRE YQNLKSAVSK 2110 2120 2130 2140 2150 2160 VLENASSVIV TRTTIKDQED LKWAFSKHET AKNKMNYKQK DLDNFTSKGK HLLSELKKIH 2170 2180 2190 2200 2210 2220 SSDFSLVKTD MESTVDKWLD VSEKLEENMD RLRVSLSIWD DVLSTRDEIE GWSNNCVPQM 2230 2240 2250 2260 2270 2280 AENISNLDNH LRAEELLKEF ESEVKNKALR LEELHSKVND LKELTKNLET PPDLQFIEAD 2290 2300 2310 2320 2330 2340 LMQKLEHAKE ITEVAKGTLK DFTAQSTQVE KFINDITTWF TKVEESLMNC AQNETCEALK 2350 2360 2370 2380 2390 2400 KVKDIQKELQ SQQSNISSTQ ENLNSLCRKY HSAELESLGR AMTGLIKKHE AVSQLCSKTQ 2410 2420 2430 2440 2450 2460 ASLQESLEKH FSESMQEFQE WFLGAKAAAK ESSDRTGDSK VLEAKLHDLQ NILDSVSDGQ 2470 2480 2490 2500 2510 2520 SKLDAVTQEG QTLYAHLSKQ IVSSIQEQIT KANEEFQAFL KQCLKDKQAL QDCASELGSF 2530 2540 2550 2560 2570 2580 EDQHRKLNLW IHEMEERFNT ENLGESKQHI PEKKNEVHKV EMFLGELLAA RESLDKLSQR 2590 2600 2610 2620 2630 2640 GQLLSEEGHG AGQEGRLCSQ LLTSHQNLLR MTKEKLRSCQ VALQEHEALE EALQSMWFWV 2650 2660 2670 2680 2690 2700 KAIQDRLACA ESTLGSKDTL EKRLSQIQDI LLMKGEGEVK LNMAIGKGEQ ALRSSNKEGQ 2710 2720 2730 2740 2750 2760 RVIQTQLETL KEVWADIMSS SVHAQSTLES VISQWNDYVE RKNQLEQWME SVDQKIEHPL 2770 2780 2790 2800 2810 2820 QPQPGLKEKF VLLDHLQSIL SEAEDHTRAL HRLIAKSREL YEKTEDESFK DTAQEELKTQ 2830 2840 2850 2860 2870 2880 FNDIMTVAKE KMRKVEEIVK DHLMYLDAVH EFTDWLHSAK EELHRWSDMS GDSSATQKKL 2890 2900 2910 2920 2930 2940 SKIKELIDSR EIGASRLSRV ESLAPEVKQN TTASGCELMH TEMQALRADW KQWEDSVFQT 2950 2960 2970 2980 2990 3000 QSCLENLVSQ MALSEQEFSG QVAQLEQALE QFSALLKTWA QQLTLLEGKN TDEEIVECWH 3010 3020 3030 3040 3050 3060 KGQEILDALQ KAEPRTEDLK SQLNELCRFS RDLSTYSGKV SGLIKEYNCL CLQASKGCQN 3070 3080 3090 3100 3110 3120 KEQILQQRFR KAFRDFQQWL VNAKITTAKC FDIPQNISEV STSLQKIQEF LSESENGQHK 3130 3140 3150 3160 3170 3180 LNMMLSKGEL LSTLLTKEKA KGIQAKVTAA KEDWKNFHSN LHQKESALEN LKIQMKDFEV 3190 3200 3210 3220 3230 3240 SAEPIQDWLS KTEKMVHESS NRLYDLPAKR REQQKLQSVL EEIHCYEPQL NRLKEKAQQL 3250 3260 3270 3280 3290 3300 WEGQAASKSF RHRVSQLSSQ YLALSNLTKE KVSRLDRIVA EHNQFSLGIK ELQDWMTDAI 3310 3320 3330 3340 3350 3360 HMLDSYCHPT SDKSVLDSRT LKLEALLSVK QEKEIQMKMI VTRGESVLQN TSPEGIPTIQ 3370 3380 3390 3400 3410 3420 QQLQSVKDMW ASLLSAGIRC KSQLEGALSK WTSYQDGVRQ FSGWMDSMEA NLNESERQHA 3430 3440 3450 3460 3470 3480 ELRDKTTMLG KAKLLNEEVL SYSSLLETIE VKGAGMTEHY VTQLELQDLQ ERYRAIQERA 3490 3500 3510 3520 3530 3540 KEAVTKSEKL VRLHQEYQRD LKAFEVWLGQ EQEKLDQYSV LEGDAHTHET TLRDLQELQV 3550 3560 3570 3580 3590 3600 HCAEGQALLN SVLHTREDVI PSGIPQAEDR ALESLRQDWQ AYQHRLSETR TQFNNVVNKL 3610 3620 3630 3640 3650 3660 RLMEQKFQQV DEWLKTAEEK VSPRTRRQSN RATKEIQLHQ MKKWHEEVTA YRDEVEEVGA 3670 3680 3690 3700 3710 3720 RAQEILDESH VNSRMGCQAT QLTSRYQALL LQVLEQIKFL EEEIQSLEES ESSLSSYSDW 3730 3740 3750 3760 3770 3780 YGSTHKNFKN VATKIDKVDT VMMGKKLKTL EVLLKDMEKG HSLLKSAREK GERAVKYLEE 3790 3800 3810 3820 3830 3840 GEAERLRKEI HDHMEQLKEL TSTVRKEHMT LEKGLHLAKE FSDKCKALTQ WIAEYQEILH 3850 3860 3870 3880 3890 3900 VPEEPKMELY EKKAQLSKYK SLQQTVLSHE PSVKSVREKG EALLELVQDV TLKDKIDQLQ 3910 3920 3930 3940 3950 3960 SDYQDLCSIG KEHVFSLEAK VKDHEDYNSE LQEVEKWLLQ MSGRLVAPDL LETSSLETIT 3970 3980 3990 4000 4010 4020 QQLAHHKAMM EEIAGFEDRL NNLQMKGDTL IGQCADHLQA KLKQNVHAHL QGTKDSYSAI 4030 4040 4050 4060 4070 4080 CSTAQRMYQS LEHELQKHVS RQDTLQQCQA WLSAVQPDLE PSPQPPLSRA EAIKQVKHFR 4090 4100 4110 4120 4130 4140 ALQEQARTYL DLLCSMCDLS NASVKTTAKD IQQTEQTIEQ KLVQAQNLTQ GWEEIKHLKS 4150 4160 4170 4180 4190 4200 ELWIYLQDAD QQLQNMKRRH SELELNIAQN MVSQVKDFVK KLQSKQASVN TIIEKVNKLT 4210 4220 4230 4240 4250 4260 KKEESPEHKE INHLNDQWLD LCRQSNNLCL QREEDLQRTR DYHDCMNVVE VFLEKFTTEW 4270 4280 4290 4300 4310 4320 DNLARSDAES TAVHLEALKK LALALQERKY AIEDLKDQKQ KMIEHLNLDD KELVKEQTSH 4330 4340 4350 4360 4370 4380 LEQRWFQLED LIKRKIQVSV TNLEELNVVQ SRFQELMEWA EEQQPNIAEA LKQSPPPDMA 4390 4400 4410 4420 4430 4440 QNLLMDHLAI CSELEAKQML LKSLIKDADR VMADLGLNER QVIQKALSDA QSHVNCLSDL 4450 4460 4470 4480 4490 4500 VGQRRKYLNK ALSEKTQFLM AVFQATSQIQ QHERKIMFRE HICLLPDDVS KQVKTCKSAQ 4510 4520 4530 4540 4550 4560 ASLKTYQNEV TGLWAQGREL MKEVTEQEKS EVLGKLQELQ SVYDSVLQKC SHRLQELEKN 4570 4580 4590 4600 4610 4620 LVSRKHFKED FDKACHWLKQ ADIVTFPEIN LMNESSELHT QLAKYQNILE QSPEYENLLL 4630 4640 4650 4660 4670 4680 TLQRTGQTIL PSLNEVDHSY LSEKLNALPR QFNVIVALAK DKFYKVQEAI LARKEYASLI 4690 4700 4710 4720 4730 4740 ELTTQSLSEL EAQFLRMSKV PTDLAVEEAL SLQDGCRAIL DEVAGLGEAV DELNQKKEGF 4750 4760 4770 4780 4790 4800 RSTGQPWQPD KMLHLVTLYH RLKRQTEQRV SLLEDTTSAY QEHEKMCQQL ERQLKSVKEE 4810 4820 4830 4840 4850 4860 QSKVNEETLP AEEKLKMYHS LAGSLQDSGI VLKRVTIHLE DLAPHLDPLA YEKARHQIQS 4870 4880 4890 4900 4910 4920 WQGELKLLTS AIGETVTECE SRMVQSIDFQ TEMSRSLDWL RRVKAELSGP VYLDLNLQDI 4930 4940 4950 4960 4970 4980 QEEIRKIQIH QEEVQSSLRI MNALSHKEKE KFTKAKELIS ADLEHSLAEL SELDGDIQEA 4990 5000 5010 5020 5030 5040 LRTRQATLTE IYSQCQRYYQ VFQAANDWLE DAQELLQLAG NGLDVESAEE NLKSHMEFFS 5050 5060 5070 5080 5090 5100 TEDQFHSNLE ELHSLVATLD PLIKPTGKED LEQKVASLEL RSQRMSRDSG AQVDLLQRCT 5110 5120 5130 5140 5150 5160 AQWHDYQKAR EEVIELMNDT EKKLSEFSLL KTSSSHEAEE KLSEHKALVS VVNSFHEKIV 5170 5180 5190 5200 5210 5220 ALEEKASQLE KTGNDASKAT LSRSMTTVWQ RWTRLRAVAQ DQEKILEDAV DEWTGFNNKV 5230 5240 5250 5260 5270 5280 KKATEMIDQL QDKLPGSSAE KASKAELLTL LEYHDTFVLE LEQQQSALGM LRQQTLSMLQ 5290 5300 5310 5320 5330 5340 DGAAPTPGEE PPLMQEITAM QDRCLNMQEK VKTNGKLVKQ ELKDREMVET QINSVKCWVQ 5350 5360 5370 5380 5390 5400 ETKEYLGNPT IEIDAQLEEL QILLTEATNH RQNIEKMAEE QKEKYLGLYT ILPSELSLQL 5410 5420 5430 5440 5450 5460 AEVALDLKIR DQIQDKIKEV EQSKATSQEL SRQIQKLAKD LTTILTKLKA KTDNVVQAKT 5470 5480 5490 5500 5510 5520 DQKVLGEELD GCNSKLMELD AAVQKFLEQN GQLGKPLAKK IGKLTELHQQ TIRQAENRLS 5530 5540 5550 5560 5570 5580 KLNQAASHLE EYNEMLELIL KWIEKAKVLA HGTIAWNSAS QLREQYILHQ VTLGKIIFKK « Hide
Isoform 8 (Beta 2) [UniParc]. Checksum: 9D23ECB198DE3636 Show »	FASTA	3,212	367,873
10 20 30 40 50 60 MTEKLQYLTS VYCTEKMSQQ VAELGRETEE LRQMIKIRLQ NLQDAAKDMK KFEAELKKLQ 70 80 90 100 110 120 AALEQAQATL TSPEVGRLSL KEQLSHRQHL LSEMESLKPK VQAVQLCQSA LRIPEDVVAS 130 140 150 160 170 180 LPLCHAALRL QEEASRLQHT AIQQCNIMQE AVVQYEQYEQ EMKHLQQLIE GAHREIEDKP 190 200 210 220 230 240 VATSNIQELQ AQISRHEELA QKIKGYQEQI ASLNSKCKML TMKAKHATML LTVTEVEGLA 250 260 270 280 290 300 EGTEDLDGEL LPTPSAHPSV VMMTAGRCHT LLSPVTEESG EEGTNSEISS PPACRSPSPV 310 320 330 340 350 360 ANTDASVNQD IAYYQALSAE RLQTDAAKIH PSTSASQEFY EPGLEPSATA KLGDLQRSWE 370 380 390 400 410 420 TLKNVISEKQ RTLYEALERQ QKYQDSLQSI STKMEAIELK LSESPEPGRS PESQMAEHQA 430 440 450 460 470 480 LMDEILMLQD EINELQSSLA EELVSESCEA DPAEQLALQS TLTVLAERMS TIRMKASGKR 490 500 510 520 530 540 QLLEEKLNDQ LEEQRQEQAL QRYRCEADEL DSWLLSTKAT LDTALSPPKE PMDMEAQLMD 550 560 570 580 590 600 CQNMLVEIEQ KVVALSELSV HNENLLLEGK AHTKDEAEQL AGKLRRLKGS LLELQRALHD 610 620 630 640 650 660 KQLNMQGTAQ EKEESDVDLT ATQSPGVQEW LAQARTTWTQ QRQSSLQQQK ELEQELAEQK 670 680 690 700 710 720 SLLRSVASRG EEILIQHSAA ETSGDAGEKP DVLSQELGME GEKSSAEDQM RMKWESLHQE 730 740 750 760 770 780 FSTKQKLLQN VLEQEQEQVL YSRPNRLLSG VPLYKGDVPT QDKSAVTSLL DGLNQAFEEV 790 800 810 820 830 840 SSQSGGAKRQ SIHLEQKLYD GVSATSTWLD DVEERLFVAT ALLPEETETC LFNQEILAKD 850 860 870 880 890 900 IKEMSEEMDK NKNLFSQAFP ENGDNRDVIE DTLGCLLGRL SLLDSVVNQR CHQMKERLQQ 910 920 930 940 950 960 ILNFQNDLKV LFTSLADNKY IILQKLANVF EQPVAEQIEA IQQAEDGLKE FDAGIIELKR 970 980 990 1000 1010 1020 RGDKLQVEQP SMQELSKLQD MYDELMMIIG SRRSGLNQNL TLKSQYERAL QDLADLLETG 1030 1040 1050 1060 1070 1080 QEKMAGDQKI IVSSKEEIQQ LLDKHKEYFQ GLESHMILTE TLFRKIISFA VQKETQFHTE 1090 1100 1110 1120 1130 1140 LMAQASAVLK RAHKRGVELE YILETWSHLD EDQQELSRQL EVVESSIPSV GLVEENEDRL 1150 1160 1170 1180 1190 1200 IDRITLYQHL KSSLNEYQPK LYQVLDDGKR LLISISCSDL ESQLNQLGEC WLSNTNKMSK 1210 1220 1230 1240 1250 1260 ELHRLETILK HWTRYQSESA DLIHWLQSAK DRLEFWTQQS VTVPQELEMV RDHLNAFLEF 1270 1280 1290 1300 1310 1320 SKEVDAQSSL KSSVLSTGNQ LLRLKKVDTA TLRSELSRID SQWTDLLTNI PAVQEKLHQL 1330 1340 1350 1360 1370 1380 QMDKLPSRHA ISEVMSWISL MENVIQKDED NIKNSIGYKA IHEYLQKYKG FKIDINCKQL 1390 1400 1410 1420 1430 1440 TVDFVNQSVL QISSQDVESK RSDKTDFAEQ LGAMNKSWQI LQGLVTEKIQ LLEGLLESWS 1450 1460 1470 1480 1490 1500 EYENNVQCLK TWFETQEKRL KQQHRIGDQA SVQNALKDCQ DLEDLIKAKE KEVEKIEQNG 1510 1520 1530 1540 1550 1560 LALIQNKKED VSSIVMSTLR ELGQTWANLD HMVGQLKILL KSVLDQWSSH KVAFDKINSY 1570 1580 1590 1600 1610 1620 LMEARYSLSR FRLLTGSLEA VQVQVDNLQN LQDDLEKQER SLQKFGSITN QLLKECHPPV 1630 1640 1650 1660 1670 1680 TETLTNTLKE VNMRWNNLLE EIAEQLQSSK ALLQLWQRYK DYSKQCASTV QQQEDRTNEL 1690 1700 1710 1720 1730 1740 LKAATNKDIA DDEVATWIQD CNDLLKGLGT VKDSLFFLHE LGEQLKQQVD ASAASAIQSD 1750 1760 1770 1780 1790 1800 QLSLSQHLCA LEQALCKQQT SLQAGVLDYE TFAKSLEALE AWIVEAEEIL QGQDPSHSSD 1810 1820 1830 1840 1850 1860 LSTIQERMEE LKGQMLKFSS MAPDLDRLNE LGYRLPLNDK EIKRMQNLNR HWSLISSQTT 1870 1880 1890 1900 1910 1920 ERFSKLQSFL LQHQTFLEKC ETWMEFLVQT EQKLAVEISG NYQHLLEQQR AHELFQAEMF 1930 1940 1950 1960 1970 1980 SRQQILHSII IDGQRLLEQG QVDDRDEFNL KLTLLSNQWQ GVIRRAQQRR GIIDSQIRQW 1990 2000 2010 2020 2030 2040 QRYREMAEKL RKWLVEVSYL PMSGLGSVPI PLQQARTLFD EVQFKEKVFL RQQGSYILTV 2050 2060 2070 2080 2090 2100 EAGKQLLLSA DSGAEAALQA ELAEIQEKWK SASMRLEEQK KKLAFLLKDW EKCEKGIADS 2110 2120 2130 2140 2150 2160 LEKLRTFKKK LSQSLPDHHE ELHAEQMRCK ELENAVGSWT DDLTQLSLLK DTLSAYISAD 2170 2180 2190 2200 2210 2220 DISILNERVE LLQRQWEELC HQLSLRRQQI GERLNEWAVF SEKNKELCEW LTQMESKVSQ 2230 2240 2250 2260 2270 2280 NGDILIEEMI EKLKKDYQEE IAIAQENKIQ LQQMGERLAK ASHESKASEI EYKLGKVNDR 2290 2300 2310 2320 2330 2340 WQHLLDLIAA RVKKLKETLV AVQQLDKNMS SLRTWLAHIE SELAKPIVYD SCNSEEIQRK 2350 2360 2370 2380 2390 2400 LNEQQELQRD IEKHSTGVAS VLNLCEVLLH DCDACATDAE CDSIQQATRN LDRRWRNICA 2410 2420 2430 2440 2450 2460 MSMERRLKIE ETWRLWQKFL DDYSRFEDWL KSSERTAAFP SSSGVIYTVA KEELKKFEAF 2470 2480 2490 2500 2510 2520 QRQVHECLTQ LELINKQYRR LARENRTDSA CSLKQMVHEG NQRWDNLQKR VTSILRRLKH 2530 2540 2550 2560 2570 2580 FIGQREEFET ARDSILVWLT EMDLQLTNIE HFSECDVQAK IKQLKAFQQE ISLNHNKIEQ 2590 2600 2610 2620 2630 2640 IIAQGEQLIE KSEPLDAAII EEELDELRRY CQEVFGRVER YHKKLIRLPL PDDEHDLSDR 2650 2660 2670 2680 2690 2700 ELELEDSAAL SDLHWHDRSA DSLLSPQPSS NLSLSLAQPL RSERSGRDTP ASVDSIPLEW 2710 2720 2730 2740 2750 2760 DHDYDLSRDL ESAMSRALPS EDEEGQDDKD FYLRGAVGLS GDHSALESQI RQLGKALDDS 2770 2780 2790 2800 2810 2820 RFQIQQTENI IRSKTPTGPE LDTSYKGYMK LLGECSSSID SVKRLEHKLK EEEESLPGFV 2830 2840 2850 2860 2870 2880 NLHSTETQTA GVIDRWELLQ AQALSKELRM KQNLQKWQQF NSDLNSIWAW LGDTEEELEQ 2890 2900 2910 2920 2930 2940 LQRLELSTDI QTIELQIKKL KELQKAVDHR KAIILSINLC SPEFTQADSK ESRDLQDRLS 2950 2960 2970 2980 2990 3000 QMNGRWDRVC SLLEEWRGLL QDALMQCQGF HEMSHGLLLM LENIDRRKNE IVPIDSNLDA 3010 3020 3030 3040 3050 3060 EILQDHHKQL MQIKHELLES QLRVASLQDM SCQLLVNAEG TDCLEAKEKV HVIGNRLKLL 3070 3080 3090 3100 3110 3120 LKEVSRHIKE LEKLLDVSSS QQDLSSWSSA DELDTSGSVS PTSGRSTPNR QKTPRGKCSL 3130 3140 3150 3160 3170 3180 SQPGPSVSSP HSRSTKGGSD SSLSEPGPGR SGRGFLFRVL RAALPLQLLL LLLIGLACLV 3190 3200 3210 PMSEEDYSCA LSNNFARSFH PMLRYTNGPP PL « Hide
Isoform 9 (Alpha 2) [UniParc]. Checksum: 621DAF9F731FEC9F Show »	FASTA	977	111,583
10 20 30 40 50 60 MVVAEDLSAL RMAEDGCVDA DLPDCNCDVT RARVKKLKET LVAVQQLDKN MSSLRTWLAH 70 80 90 100 110 120 IESELAKPIV YDSCNSEEIQ RKLNEQQELQ RDIEKHSTGV ASVLNLCEVL LHDCDACATD 130 140 150 160 170 180 AECDSIQQAT RNLDRRWRNI CAMSMERRLK IEETWRLWQK FLDDYSRFED WLKSSERTAA 190 200 210 220 230 240 FPSSSGVIYT VAKEELKKFE AFQRQVHECL TQLELINKQY RRLARENRTD SACSLKQMVH 250 260 270 280 290 300 EGNQRWDNLQ KRVTSILRRL KHFIGQREEF ETARDSILVW LTEMDLQLTN IEHFSECDVQ 310 320 330 340 350 360 AKIKQLKAFQ QEISLNHNKI EQIIAQGEQL IEKSEPLDAA IIEEELDELR RYCQEVFGRV 370 380 390 400 410 420 ERYHKKLIRL PLPDDEHDLS DRELELEDSA ALSDLHWHDR SADSLLSPQP SSNLSLSLAQ 430 440 450 460 470 480 PLRSERSGRD TPASVDSIPL EWDHDYDLSR DLESAMSRAL PSEDEEGQDD KDFYLRGAVG 490 500 510 520 530 540 LSDVMIPESP EAYVKLTENA IKNTSGDHSA LESQIRQLGK ALDDSRFQIQ QTENIIRSKT 550 560 570 580 590 600 PTGPELDTSY KGYMKLLGEC SSSIDSVKRL EHKLKEEEES LPGFVNLHST ETQTAGVIDR 610 620 630 640 650 660 WELLQAQALS KELRMKQNLQ KWQQFNSDLN SIWAWLGDTE EELEQLQRLE LSTDIQTIEL 670 680 690 700 710 720 QIKKLKELQK AVDHRKAIIL SINLCSPEFT QADSKESRDL QDRLSQMNGR WDRVCSLLEE 730 740 750 760 770 780 WRGLLQDALM QCQGFHEMSH GLLLMLENID RRKNEIVPID SNLDAEILQD HHKQLMQIKH 790 800 810 820 830 840 ELLESQLRVA SLQDMSCQLL VNAEGTDCLE AKEKVHVIGN RLKLLLKEVS RHIKELEKLL 850 860 870 880 890 900 DVSSSQQDLS SWSSADELDT SGSVSPTSGR STPNRQKTPR GKCSLSQPGP SVSSPHSRST 910 920 930 940 950 960 KGGSDSSLSE PGPGRSGRGF LFRVLRAALP LQLLLLLLIG LACLVPMSEE DYSCALSNNF 970 ARSFHPMLRY TNGPPPL « Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues." Zhang Q., Skepper J.N., Yang F., Davies J.D., Hegyi L., Roberts R.G., Weissberg P.L., Ellis J.A., Shanahan C.M. J. Cell Sci. 114:4485-4498(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF 8758-LEU--CYS-8763, VARIANTS VAL-7302 AND ALA-8323. Tissue: Heart, Placenta, Skeletal muscle, Spleen and Testis.
[2]	"The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300." Zhang Q., Ragnauth C., Greener M.J., Shanahan C.M., Roberts R.G. Genomics 80:473-481(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, VARIANTS THR-4596; MET-5015; VAL-7302 AND ALA-8323. Tissue: Heart, Spleen and Testis.
[3]	"Enaptin, a giant actin-binding protein, is an element of the nuclear membrane and the actin cytoskeleton." Padmakumar V.C., Abraham S., Braune S., Noegel A.A., Tunggal B., Karakesisoglou I., Korenbaum E. Exp. Cell Res. 295:330-339(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), TISSUE SPECIFICITY. Tissue: Cerebellum.
[4]	Zhang Q., Shanahan C.M. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 8 AND 9), VARIANTS VAL-7302 AND ALA-8323.
[5]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"Golgi localization of Syne-1." Gough L.L., Fan J., Chu S., Winnick S., Beck K.A. Mol. Biol. Cell 14:2410-2424(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-856 (ISOFORM 1). Tissue: Kidney.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 28-778 AND 2901-3476 (ISOFORM 1). Tissue: Adrenal gland and Teratocarcinoma.
[8]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 443-8797 (ISOFORM 5). Tissue: Brain.
[9]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 743-8797 (ISOFORM 6). Tissue: Brain.
[10]	"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4219-8797 (ISOFORM 7), VARIANTS THR-4596 AND MET-5015. Tissue: Brain.
[11]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6922-8797 (ISOFORM 1), VARIANTS VAL-7302 AND ALA-8323. Tissue: Brain.
[12]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[13]	"Myne-1, a spectrin repeat transmembrane protein of the myocyte inner nuclear membrane, interacts with lamin A/C." Mislow J.M.K., Kim M.S., Davis D.B., McNally E.M. J. Cell Sci. 115:61-70(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7631-8797 (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT ALA-8323.
[14]	Ma F.-R., Zhu L.-P. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8406-8797 (ISOFORM 1).
[15]	"Nesprin-1alpha self-associates and binds directly to emerin and lamin A in vitro." Mislow J.M., Holaska J.M., Kim M.S., Lee K.K., Segura-Totten M., Wilson K.L., McNally E.M. FEBS Lett. 525:135-140(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT, INTERACTION WITH EMD AND LMNA.
[16]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8223; THR-8274; SER-8277 AND SER-8280, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[17]	"Mutations in SYNE1 lead to a newly discovered form of autosomal recessive cerebellar ataxia." Gros-Louis F., Dupre N., Dion P., Fox M.A., Laurent S., Verreault S., Sanes J.R., Bouchard J.-P., Rouleau G.A. Nat. Genet. 39:80-85(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN SCAR8.
[18]	"Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness." Stewart-Hutchinson P.J., Hale C.M., Wirtz D., Hodzic D. Exp. Cell Res. 314:1892-1905(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DOMAIN, INTERACTION WITH SUN1 AND SUN2.
[19]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[20]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[21]	"Cytoskeletal interactions at the nuclear envelope mediated by nesprins." Taranum S., Sur I., Muller R., Lu W., Rashmi R.N., Munck M., Neumann S., Karakesisoglou I., Noegel A.A. Int. J. Cell Biol. 2012:736524-736524(2012) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, INTERACTION WITH SYNE3.
[22]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS COLORECTAL CANCER [LARGE SCALE ANALYSIS] MET-3671; ASP-4210; HIS-4223; ARG-5507 AND HIS-8468.
[23]	"Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity." Zhang Q., Bethmann C., Worth N.F., Davies J.D., Wasner C., Feuer A., Ragnauth C.D., Yi Q., Mellad J.A., Warren D.T., Wheeler M.A., Ellis J.A., Skepper J.N., Vorgerd M., Schlotter-Weigel B., Weissberg P.L., Roberts R.G., Wehnert M., Shanahan C.M. Hum. Mol. Genet. 16:2816-2833(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS EDMD4 HIS-8095; LEU-8387 AND LYS-8461.
+	Additional computationally mapped references.

Web resources

GeneReviews

Wikipedia

Enaptin entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY061755 mRNA. Translation: AAL33798.1.
AY061756 mRNA. Translation: AAL33799.1.
AF495910 mRNA. Translation: AAN60442.1.
AF535142 mRNA. Translation: AAN03486.1.
AY184203 mRNA. Translation: AAO27771.1.
AY184206 mRNA. Translation: AAO27774.1.
AL049548 Genomic DNA. No translation available.
AL136079 Genomic DNA. No translation available.
AL589963 Genomic DNA. No translation available.
AL591507 Genomic DNA. No translation available.
AL450401, AL078582, AL138832 Genomic DNA. Translation: CAI40728.1.
AL450401

AL357081 Genomic DNA. Translation: CAI40729.1.
AL357081

AL450401 Genomic DNA. Translation: CAI41322.1.
AL078582, AL138832, AL450401 Genomic DNA. Translation: CAI42283.1.
AL078582

AL450401 Genomic DNA. Translation: CAI42284.1.
AL138832, AL078582, AL450401 Genomic DNA. Translation: CAI42785.1.
AL138832

AL450401 Genomic DNA. Translation: CAI42786.1.
AY135172 mRNA. Translation: AAM95335.1. Sequence problems.
AY183142 mRNA. Translation: AAO23669.1.
AK056122 mRNA. Translation: BAB71097.1. Sequence problems.
AK094094 mRNA. Translation: BAC04284.1. Different initiation.
AB051543 mRNA. Translation: BAB21847.1.
AL713682 mRNA. Translation: CAD28486.2. Different initiation.
AB033088 mRNA. Translation: BAA86576.1.
AB018339 mRNA. Translation: BAA34516.2.
AF444779 mRNA. Translation: AAL38031.1. Different initiation.
AF043290 mRNA. Translation: AAC02992.2. Different initiation.

RefSeq

NP_149062.1. NM_033071.3.
NP_892006.3. NM_182961.3.

UniGene

Hs.12967.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4DXR	X-ray	2.32	B	8769-8797	[»]

ProteinModelPortal

Q8NF91.

ModBase

Search...

MobiDB

Search...

Protein-protein interaction databases

BioGrid

116928. 22 interactions.

IntAct

Q8NF91. 16 interactions.

MINT

MINT-6489007.

PTM databases

PhosphoSite

Q8NF91.

Polymorphism databases

DMDM

257051067.

Proteomic databases

PaxDb

Q8NF91.

PRIDE

Q8NF91.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000367253; ENSP00000356222; ENSG00000131018.
ENST00000367255; ENSP00000356224; ENSG00000131018.
ENST00000413186; ENSP00000414510; ENSG00000131018.
ENST00000423061; ENSP00000396024; ENSG00000131018.

GeneID

23345.

KEGG

hsa:23345.

UCSC

uc003qou.4. human.

Organism-specific databases

CTD

23345.

GeneCards

GC06M152485.

HGNC

HGNC:17089. SYNE1.

HPA

HPA019113.

MIM

608441. gene.
610743. phenotype.
612998. phenotype.

neXtProt

NX_Q8NF91.

Orphanet

98853. Autosomal dominant Emery-Dreifuss muscular dystrophy.
88644. Autosomal recessive ataxia, Beauce type.
319332. Autosomal recessive myogenic arthrogryposis multiplex congenita.

PharmGKB

PA134975331.

HUGE

Search...
Search...
Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5069.

HOVERGEN

HBG066187.

OMA

QQTENII.

OrthoDB

EOG72JWF7.

TreeFam

TF329280.

Enzyme and pathway databases

Reactome

REACT_111183. Meiosis.
REACT_115566. Cell Cycle.

Gene expression databases

ArrayExpress

Q8NF91.

Bgee

Q8NF91.

Genevestigator

Q8NF91.

Family and domain databases

Gene3D

1.10.418.10. 2 hits.

InterPro

IPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR012315. KASH.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]

Pfam

PF00307. CH. 2 hits.
PF10541. KASH. 1 hit.
PF00435. Spectrin. 10 hits.
[Graphical view]

SMART

SM00033. CH. 2 hits.
SM00150. SPEC. 45 hits.
[Graphical view]

SUPFAM

SSF47576. SSF47576. 2 hits.

PROSITE

PS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS51049. KASH. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

SYNE1. human.

GeneWiki

Enaptin.

GenomeRNAi

23345.

NextBio

45305.

PRO

Q8NF91.

SOURCE

Search...

Entry information

Entry name

SYNE1_HUMAN

Accession

Primary (citable) accession number: Q8NF91
Secondary accession number(s): E7EQI5

Q9ULF8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	November 28, 2012
Last modified:	February 19, 2014
This is version 132 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Secondary structure

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents