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UniProtKB - Q8NF91 (SYNE1_HUMAN)

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Protein

Nesprin-1

Gene

SYNE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrososme attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenenis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette.By similarity2 Publications

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: UniProtKB
  • enzyme binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • lamin binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • RNA binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  • cytoskeletal anchoring at nuclear membrane Source: UniProtKB
  • Golgi organization Source: UniProtKB
  • muscle cell differentiation Source: UniProtKB
  • nuclear matrix anchoring at nuclear membrane Source: UniProtKB
  • nucleus organization Source: UniProtKB
  • spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywordsi

Molecular functionActin-binding
Biological processDifferentiation, Spermatogenesis

Enzyme and pathway databases

ReactomeiR-HSA-1221632. Meiotic synapsis.

Names & Taxonomyi

Protein namesi
Recommended name:
Nesprin-1
Alternative name(s):
Enaptin
KASH domain-containing protein 1
Short name:
KASH1
Myocyte nuclear envelope protein 1
Short name:
Myne-1
Nuclear envelope spectrin repeat protein 1
Synaptic nuclear envelope protein 1
Short name:
Syne-1
Gene namesi
Name:SYNE1
Synonyms:C6orf98, KIAA0796, KIAA1262, KIAA1756, MYNE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:17089. SYNE1.

Subcellular locationi

Isoform GSRP-56 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8746CytoplasmicPROSITE-ProRule annotationAdd BLAST8746
Transmembranei8747 – 8767Helical; Anchor for type IV membrane proteinPROSITE-ProRule annotationAdd BLAST21
Topological domaini8768 – 8797Perinuclear spacePROSITE-ProRule annotationAdd BLAST30

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytoskeleton Source: UniProtKB-SubCell
  • Golgi apparatus Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • LINC complex Source: UniProtKB
  • nuclear envelope Source: UniProtKB
  • nuclear membrane Source: HPA
  • nuclear outer membrane Source: UniProtKB-SubCell
  • nucleolus Source: BHF-UCL
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • P-body Source: BHF-UCL
  • postsynaptic membrane Source: UniProtKB
  • sarcomere Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Spinocerebellar ataxia, autosomal recessive, 8 (SCAR8)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionSpinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR8 is an autosomal recessive form.
See also OMIM:610743
Emery-Dreifuss muscular dystrophy 4, autosomal dominant (EDMD4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Emery-Dreifuss muscular dystrophy, a degenerative myopathy characterized by weakness and atrophy of muscle without involvement of the nervous system, early contractures of the elbows, Achilles tendons and spine, and cardiomyopathy associated with cardiac conduction defects.
See also OMIM:612998
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0629748095R → H in EDMD4. 1 PublicationCorresponds to variant dbSNP:rs119103246Ensembl.1
Natural variantiVAR_0629758387V → L in EDMD4. 1 PublicationCorresponds to variant dbSNP:rs119103247Ensembl.1
Natural variantiVAR_0629768461E → K in EDMD4. 1 PublicationCorresponds to variant dbSNP:rs119103248Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi8758 – 8763Missing : Abolishes the nuclear envelope targeting, induces a cytoplasmic localization. 1 Publication6

Keywords - Diseasei

Disease mutation, Emery-Dreifuss muscular dystrophy, Neurodegeneration

Organism-specific databases

DisGeNETi23345.
MalaCardsiSYNE1.
MIMi610743. phenotype.
612998. phenotype.
OpenTargetsiENSG00000131018.
Orphaneti98853. Autosomal dominant Emery-Dreifuss muscular dystrophy.
88644. Autosomal recessive ataxia, Beauce type.
319332. Autosomal recessive myogenic arthrogryposis multiplex congenita.
PharmGKBiPA134975331.

Polymorphism and mutation databases

BioMutaiSYNE1.
DMDMi425906075.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001635911 – 8797Nesprin-1Add BLAST8797

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei732PhosphoserineBy similarity1
Modified residuei2270PhosphothreonineBy similarity1
Modified residuei5657PhosphoserineBy similarity1
Modified residuei8223PhosphoserineCombined sources1
Modified residuei8274PhosphothreonineCombined sources1
Modified residuei8277PhosphoserineCombined sources1
Modified residuei8280PhosphoserineCombined sources1
Modified residuei8305PhosphoserineBy similarity1
Modified residuei8360PhosphothreonineCombined sources1
Disulfide bondi8774Interchain (C-563 in SUN2); alternateBy similarity
Disulfide bondi8774Interchain (with C-657 in SUN1)By similarity

Post-translational modificationi

The disulfid bond with SUN1 or SUN2 is required for stability of the respective LINC complex under tensile forces.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ8NF91.
MaxQBiQ8NF91.
PaxDbiQ8NF91.
PeptideAtlasiQ8NF91.
PRIDEiQ8NF91.

PTM databases

iPTMnetiQ8NF91.
PhosphoSitePlusiQ8NF91.

Expressioni

Tissue specificityi

Expressed in HeLa, A431, A172 and HaCaT cells (at protein level). Widely expressed. Highly expressed in skeletal and smooth muscles, heart, spleen, peripheral blood leukocytes, pancreas, cerebellum, stomach, kidney and placenta. Isoform GSRP-56 is predominantly expressed in heart and skeletal muscle (at protein level).5 Publications

Gene expression databases

BgeeiENSG00000131018.
ExpressionAtlasiQ8NF91. baseline and differential.
GenevisibleiQ8NF91. HS.

Organism-specific databases

HPAiHPA019113.

Interactioni

Subunit structurei

Core component of LINC complexes which are composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN and KASH domain-containing proteins seem to bind each other promiscuously; however, differentially expression of LINC complex constituents can give rise to specific assemblies. At least SUN1/2-containing core LINC complexes are proposed to be hexameric composed of three protomers of each KASH and SUN domain-containing protein. The SUN2:SYNE1/KASH1 LINC complex is a heterohexamer; the homotrimeric cloverleave-like conformation of the SUN domain is a prerequisite for LINC complex formation in which three separate SYNE1/KASH1 peptides bind at the interface of adjacent SUN domains. Self-associates. Interacts with SYNE3. Interacts with SPAG4/SUN4. May interact with MUSK. Interacts with F-actin via its N-terminal domain. Interacts with EMD and LMNA in vitro.By similarity3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: UniProtKB
  • enzyme binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • lamin binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
Complete GO annotation...

Protein-protein interaction databases

BioGridi116928. 35 interactors.
IntActiQ8NF91. 21 interactors.
MINTiMINT-6489007.
STRINGi9606.ENSP00000356224.

Structurei

Secondary structure

18797
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8780 – 8782Combined sources3
Beta strandi8783 – 8785Combined sources3
Beta strandi8787 – 8793Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DXRX-ray2.32B8769-8797[»]
ProteinModelPortaliQ8NF91.
SMRiQ8NF91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 289Actin-bindingAdd BLAST289
Domaini27 – 134Calponin-homology 1PROSITE-ProRule annotationAdd BLAST108
Domaini178 – 283Calponin-homology 2PROSITE-ProRule annotationAdd BLAST106
Repeati314 – 397Spectrin 1Add BLAST84
Repeati398 – 502Spectrin 2Add BLAST105
Repeati503 – 609Spectrin 3Add BLAST107
Repeati610 – 703Spectrin 4Add BLAST94
Repeati704 – 815Spectrin 5Add BLAST112
Repeati816 – 923Spectrin 6Add BLAST108
Repeati924 – 1024Spectrin 7Add BLAST101
Repeati1025 – 1122Spectrin 8Add BLAST98
Repeati1123 – 1246Spectrin 9Add BLAST124
Repeati1247 – 1335Spectrin 10Add BLAST89
Repeati1336 – 1444Spectrin 11Add BLAST109
Repeati1445 – 1550Spectrin 12Add BLAST106
Repeati1551 – 1653Spectrin 13Add BLAST103
Repeati1654 – 1763Spectrin 14Add BLAST110
Repeati1764 – 1879Spectrin 15Add BLAST116
Repeati1880 – 1976Spectrin 16Add BLAST97
Repeati1977 – 2081Spectrin 17Add BLAST105
Repeati2082 – 2195Spectrin 18Add BLAST114
Repeati2196 – 2303Spectrin 19Add BLAST108
Repeati2304 – 2401Spectrin 20Add BLAST98
Repeati2402 – 2513Spectrin 21Add BLAST112
Repeati2514 – 2619Spectrin 22Add BLAST106
Repeati2620 – 2731Spectrin 23Add BLAST112
Repeati2732 – 2838Spectrin 24Add BLAST107
Repeati2839 – 2962Spectrin 25Add BLAST124
Repeati2963 – 3062Spectrin 26Add BLAST100
Repeati3063 – 3171Spectrin 27Add BLAST109
Repeati3172 – 3275Spectrin 28Add BLAST104
Repeati3276 – 3387Spectrin 29Add BLAST112
Repeati3388 – 3490Spectrin 30Add BLAST103
Repeati3491 – 3593Spectrin 31Add BLAST103
Repeati3594 – 3720Spectrin 32Add BLAST127
Repeati3721 – 3814Spectrin 33Add BLAST94
Repeati3815 – 3920Spectrin 34Add BLAST106
Repeati3921 – 4028Spectrin 35Add BLAST108
Repeati4029 – 4139Spectrin 36Add BLAST111
Repeati4140 – 4235Spectrin 37Add BLAST96
Repeati4236 – 4339Spectrin 38Add BLAST104
Repeati4340 – 4451Spectrin 39Add BLAST112
Repeati4452 – 4560Spectrin 40Add BLAST109
Repeati4561 – 4669Spectrin 41Add BLAST109
Repeati4670 – 4776Spectrin 42Add BLAST107
Repeati4777 – 4882Spectrin 43Add BLAST106
Repeati4883 – 4991Spectrin 44Add BLAST109
Repeati4992 – 5099Spectrin 45Add BLAST108
Repeati5100 – 5209Spectrin 46Add BLAST110
Repeati5210 – 5318Spectrin 47Add BLAST109
Repeati5319 – 5424Spectrin 48Add BLAST106
Repeati5425 – 5522Spectrin 49Add BLAST98
Repeati5523 – 5630Spectrin 50Add BLAST108
Repeati5631 – 5736Spectrin 51Add BLAST106
Repeati5737 – 5842Spectrin 52Add BLAST106
Repeati5962 – 6071Spectrin 53Add BLAST110
Repeati6072 – 6178Spectrin 54Add BLAST107
Repeati6374 – 6485Spectrin 55Add BLAST112
Repeati6486 – 6581Spectrin 56Add BLAST96
Repeati6582 – 6691Spectrin 57Add BLAST110
Repeati6692 – 6795Spectrin 58Add BLAST104
Repeati6796 – 6902Spectrin 59Add BLAST107
Repeati6903 – 7020Spectrin 60Add BLAST118
Repeati7021 – 7128Spectrin 61Add BLAST108
Repeati7129 – 7237Spectrin 62Add BLAST109
Repeati7238 – 7350Spectrin 63Add BLAST113
Repeati7351 – 7454Spectrin 64Add BLAST104
Repeati7455 – 7558Spectrin 65Add BLAST104
Repeati7559 – 7671Spectrin 66Add BLAST113
Repeati7672 – 7783Spectrin 67Add BLAST112
Repeati7784 – 7883Spectrin 68Add BLAST100
Repeati7884 – 7997Spectrin 69Add BLAST114
Repeati7998 – 8106Spectrin 70Add BLAST109
Repeati8107 – 8216Spectrin 71Add BLAST110
Repeati8329 – 8438Spectrin 72Add BLAST110
Repeati8439 – 8548Spectrin 73Add BLAST110
Repeati8549 – 8666Spectrin 74Add BLAST118
Domaini8738 – 8797KASHPROSITE-ProRule annotationAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili314 – 8666Sequence analysisAdd BLAST8353

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi8663 – 8729Ser-richAdd BLAST67

Domaini

The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains.1 Publication

Sequence similaritiesi

Belongs to the nesprin family.Curated

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0516. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118813.
HOVERGENiHBG066187.
InParanoidiQ8NF91.
KOiK19326.
OMAiQVRCAEG.
OrthoDBiEOG091G0007.
TreeFamiTF329280.

Family and domain databases

CDDicd00014. CH. 2 hits.
Gene3Di1.10.418.10. 2 hits.
InterProiView protein in InterPro
IPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR012315. KASH.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
IPR030265. SYNE1.
PANTHERiPTHR11915:SF362. PTHR11915:SF362. 1 hit.
PfamiView protein in Pfam
PF00307. CH. 2 hits.
PF10541. KASH. 1 hit.
PF00435. Spectrin. 10 hits.
SMARTiView protein in SMART
SM00033. CH. 2 hits.
SM01249. KASH. 1 hit.
SM00150. SPEC. 45 hits.
SUPFAMiSSF47576. SSF47576. 2 hits.
PROSITEiView protein in PROSITE
PS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS51049. KASH. 1 hit.

Sequences (12)i

Sequence statusi: Complete.

This entry describes 12 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NF91-1) [UniParc]FASTAAdd to basket
Also known as: Nesprin-1 Giant, Enaptin

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATSRGASRC PRDIANVMQR LQDEQEIVQK RTFTKWINSH LAKRKPPMVV 
        60         70         80         90        100
DDLFEDMKDG VKLLALLEVL SGQKLPCEQG RRMKRIHAVA NIGTALKFLE 
       110        120        130        140        150
GRKIKLVNIN STDIADGRPS IVLGLMWTII LYFQIEELTS NLPQLQSLSS 
       160        170        180        190        200
SASSVDSIVS SETPSPPSKR KVTTKIQGNA KKALLKWVQY TAGKQTGIEV 
       210        220        230        240        250
KDFGKSWRSG VAFHSVIHAI RPELVDLETV KGRSNRENLE DAFTIAETEL 
       260        270        280        290        300
GIPRLLDPED VDVDKPDEKS IMTYVAQFLK HYPDIHNAST DGQEDDEILP 
       310        320        330        340        350
GFPSFANSVQ NFKREDRVIF KEMKVWIEQF ERDLTRAQMV ESNLQDKYQS 
       360        370        380        390        400
FKHFRVQYEM KRKQIEHLIQ PLHRDGKLSL DQALVKQSWD RVTSRLFDWH 
       410        420        430        440        450
IQLDKSLPAP LGTIGAWLYR AEVALREEIT VQQVHEETAN TIQRKLEQHK 
       460        470        480        490        500
DLLQNTDAHK RAFHEIYRTR SVNGIPVPPD QLEDMAERFH FVSSTSELHL 
       510        520        530        540        550
MKMEFLELKY RLLSLLVLAE SKLKSWIIKY GRRESVEQLL QNYVSFIENS 
       560        570        580        590        600
KFFEQYEVTY QILKQTAEMY VKADGSVEEA ENVMKFMNET TAQWRNLSVE 
       610        620        630        640        650
VRSVRSMLEE VISNWDRYGN TVASLQAWLE DAEKMLNQSE NAKKDFFRNL 
       660        670        680        690        700
PHWIQQHTAM NDAGNFLIET CDEMVSRDLK QQLLLLNGRW RELFMEVKQY 
       710        720        730        740        750
AQADEMDRMK KEYTDCVVTL SAFATEAHKK LSEPLEVSFM NVKLLIQDLE 
       760        770        780        790        800
DIEQRVPVMD AQYKIITKTA HLITKESPQE EGKEMFATMS KLKEQLTKVK 
       810        820        830        840        850
ECYSPLLYES QQLLIPLEEL EKQMTSFYDS LGKINEIITV LEREAQSSAL 
       860        870        880        890        900
FKQKHQELLA CQENCKKTLT LIEKGSQSVQ KFVTLSNVLK HFDQTRLQRQ 
       910        920        930        940        950
IADIHVAFQS MVKKTGDWKK HVETNSRLMK KFEESRAELE KVLRIAQEGL 
       960        970        980        990       1000
EEKGDPEELL RRHTEFFSQL DQRVLNAFLK ACDELTDILP EQEQQGLQEA 
      1010       1020       1030       1040       1050
VRKLHKQWKD LQGEAPYHLL HLKIDVEKNR FLASVEECRT ELDRETKLMP 
      1060       1070       1080       1090       1100
QEGSEKIIKE HRVFFSDKGP HHLCEKRLQL IEELCVKLPV RDPVRDTPGT 
      1110       1120       1130       1140       1150
CHVTLKELRA AIDSTYRKLM EDPDKWKDYT SRFSEFSSWI STNETQLKGI 
      1160       1170       1180       1190       1200
KGEAIDTANH GEVKRAVEEI RNGVTKRGET LSWLKSRLKV LTEVSSENEA 
      1210       1220       1230       1240       1250
QKQGDELAKL SSSFKALVTL LSEVEKMLSN FGDCVQYKEI VKNSLEELIS 
      1260       1270       1280       1290       1300
GSKEVQEQAE KILDTENLFE AQQLLLHHQQ KTKRISAKKR DVQQQIAQAQ 
      1310       1320       1330       1340       1350
QGEGGLPDRG HEELRKLEST LDGLERSRER QERRIQVTLR KWERFETNKE 
      1360       1370       1380       1390       1400
TVVRYLFQTG SSHERFLSFS SLESLSSELE QTKEFSKRTE SIAVQAENLV 
      1410       1420       1430       1440       1450
KEASEIPLGP QNKQLLQQQA KSIKEQVKKL EDTLEEDIKT MEMVKTKWDH 
      1460       1470       1480       1490       1500
FGSNFETLSV WITEKEKELN ALETSSSAMD MQISQIKVTI QEIESKLSSI 
      1510       1520       1530       1540       1550
VGLEEEAQSF AQFVTTGESA RIKAKLTQIR RYGEELREHA QCLEGTILGH 
      1560       1570       1580       1590       1600
LSQQQKFEEN LRKIQQSVSE FEDKLAVPIK ICSSATETYK VLQEHMDLCQ 
      1610       1620       1630       1640       1650
ALESLSSAIT AFSASARKVV NRDSCVQEAA ALQQQYEDIL RRAKERQTAL 
      1660       1670       1680       1690       1700
ENLLAHWQRL EKELSSFLTW LERGEAKASS PEMDISADRV KVEGELQLIQ 
      1710       1720       1730       1740       1750
ALQNEVVSQA SFYSKLLQLK ESLFSVASKD DVKMMKLHLE QLDERWRDLP 
      1760       1770       1780       1790       1800
QIINKRINFL QSVVAEHQQF DELLLSFSVW IKLFLSELQT TSEISIMDHQ 
      1810       1820       1830       1840       1850
VALTRHKDHA AEVESKKGEL QSLQGHLAKL GSLGRAEDLH LLQGKAEDCF 
      1860       1870       1880       1890       1900
QLFEEASQVV ERRQLALSHL AEFLQSHASL SGILRQLRQT VEATNSMNKN 
      1910       1920       1930       1940       1950
ESDLIEKDLN DALQNAKALE SAAVSLDGIL SKAQYHLKIG SSEQRTSCRA 
      1960       1970       1980       1990       2000
TADQLCGEVE RIQNLLGTKQ SEADALAVLK KAFQDQKEEL LKSIEDIEER 
      2010       2020       2030       2040       2050
TDKERLKEPT RQALQQRLRV FNQLEDELNS HEHELCWLKD KAKQIAQKDV 
      2060       2070       2080       2090       2100
AFAPEVDREI NRLEVTWDDT KRLIHENQGQ CCGLIDLMRE YQNLKSAVSK 
      2110       2120       2130       2140       2150
VLENASSVIV TRTTIKDQED LKWAFSKHET AKNKMNYKQK DLDNFTSKGK 
      2160       2170       2180       2190       2200
HLLSELKKIH SSDFSLVKTD MESTVDKWLD VSEKLEENMD RLRVSLSIWD 
      2210       2220       2230       2240       2250
DVLSTRDEIE GWSNNCVPQM AENISNLDNH LRAEELLKEF ESEVKNKALR 
      2260       2270       2280       2290       2300
LEELHSKVND LKELTKNLET PPDLQFIEAD LMQKLEHAKE ITEVAKGTLK 
      2310       2320       2330       2340       2350
DFTAQSTQVE KFINDITTWF TKVEESLMNC AQNETCEALK KVKDIQKELQ 
      2360       2370       2380       2390       2400
SQQSNISSTQ ENLNSLCRKY HSAELESLGR AMTGLIKKHE AVSQLCSKTQ 
      2410       2420       2430       2440       2450
ASLQESLEKH FSESMQEFQE WFLGAKAAAK ESSDRTGDSK VLEAKLHDLQ 
      2460       2470       2480       2490       2500
NILDSVSDGQ SKLDAVTQEG QTLYAHLSKQ IVSSIQEQIT KANEEFQAFL 
      2510       2520       2530       2540       2550
KQCLKDKQAL QDCASELGSF EDQHRKLNLW IHEMEERFNT ENLGESKQHI 
      2560       2570       2580       2590       2600
PEKKNEVHKV EMFLGELLAA RESLDKLSQR GQLLSEEGHG AGQEGRLCSQ 
      2610       2620       2630       2640       2650
LLTSHQNLLR MTKEKLRSCQ VALQEHEALE EALQSMWFWV KAIQDRLACA 
      2660       2670       2680       2690       2700
ESTLGSKDTL EKRLSQIQDI LLMKGEGEVK LNMAIGKGEQ ALRSSNKEGQ 
      2710       2720       2730       2740       2750
RVIQTQLETL KEVWADIMSS SVHAQSTLES VISQWNDYVE RKNQLEQWME 
      2760       2770       2780       2790       2800
SVDQKIEHPL QPQPGLKEKF VLLDHLQSIL SEAEDHTRAL HRLIAKSREL 
      2810       2820       2830       2840       2850
YEKTEDESFK DTAQEELKTQ FNDIMTVAKE KMRKVEEIVK DHLMYLDAVH 
      2860       2870       2880       2890       2900
EFTDWLHSAK EELHRWSDMS GDSSATQKKL SKIKELIDSR EIGASRLSRV 
      2910       2920       2930       2940       2950
ESLAPEVKQN TTASGCELMH TEMQALRADW KQWEDSVFQT QSCLENLVSQ 
      2960       2970       2980       2990       3000
MALSEQEFSG QVAQLEQALE QFSALLKTWA QQLTLLEGKN TDEEIVECWH 
      3010       3020       3030       3040       3050
KGQEILDALQ KAEPRTEDLK SQLNELCRFS RDLSTYSGKV SGLIKEYNCL 
      3060       3070       3080       3090       3100
CLQASKGCQN KEQILQQRFR KAFRDFQQWL VNAKITTAKC FDIPQNISEV 
      3110       3120       3130       3140       3150
STSLQKIQEF LSESENGQHK LNMMLSKGEL LSTLLTKEKA KGIQAKVTAA 
      3160       3170       3180       3190       3200
KEDWKNFHSN LHQKESALEN LKIQMKDFEV SAEPIQDWLS KTEKMVHESS 
      3210       3220       3230       3240       3250
NRLYDLPAKR REQQKLQSVL EEIHCYEPQL NRLKEKAQQL WEGQAASKSF 
      3260       3270       3280       3290       3300
RHRVSQLSSQ YLALSNLTKE KVSRLDRIVA EHNQFSLGIK ELQDWMTDAI 
      3310       3320       3330       3340       3350
HMLDSYCHPT SDKSVLDSRT LKLEALLSVK QEKEIQMKMI VTRGESVLQN 
      3360       3370       3380       3390       3400
TSPEGIPTIQ QQLQSVKDMW ASLLSAGIRC KSQLEGALSK WTSYQDGVRQ 
      3410       3420       3430       3440       3450
FSGWMDSMEA NLNESERQHA ELRDKTTMLG KAKLLNEEVL SYSSLLETIE 
      3460       3470       3480       3490       3500
VKGAGMTEHY VTQLELQDLQ ERYRAIQERA KEAVTKSEKL VRLHQEYQRD 
      3510       3520       3530       3540       3550
LKAFEVWLGQ EQEKLDQYSV LEGDAHTHET TLRDLQELQV HCAEGQALLN 
      3560       3570       3580       3590       3600
SVLHTREDVI PSGIPQAEDR ALESLRQDWQ AYQHRLSETR TQFNNVVNKL 
      3610       3620       3630       3640       3650
RLMEQKFQQV DEWLKTAEEK VSPRTRRQSN RATKEIQLHQ MKKWHEEVTA 
      3660       3670       3680       3690       3700
YRDEVEEVGA RAQEILDESH VNSRMGCQAT QLTSRYQALL LQVLEQIKFL 
      3710       3720       3730       3740       3750
EEEIQSLEES ESSLSSYSDW YGSTHKNFKN VATKIDKVDT VMMGKKLKTL 
      3760       3770       3780       3790       3800
EVLLKDMEKG HSLLKSAREK GERAVKYLEE GEAERLRKEI HDHMEQLKEL 
      3810       3820       3830       3840       3850
TSTVRKEHMT LEKGLHLAKE FSDKCKALTQ WIAEYQEILH VPEEPKMELY 
      3860       3870       3880       3890       3900
EKKAQLSKYK SLQQTVLSHE PSVKSVREKG EALLELVQDV TLKDKIDQLQ 
      3910       3920       3930       3940       3950
SDYQDLCSIG KEHVFSLEAK VKDHEDYNSE LQEVEKWLLQ MSGRLVAPDL 
      3960       3970       3980       3990       4000
LETSSLETIT QQLAHHKAMM EEIAGFEDRL NNLQMKGDTL IGQCADHLQA 
      4010       4020       4030       4040       4050
KLKQNVHAHL QGTKDSYSAI CSTAQRMYQS LEHELQKHVS RQDTLQQCQA 
      4060       4070       4080       4090       4100
WLSAVQPDLE PSPQPPLSRA EAIKQVKHFR ALQEQARTYL DLLCSMCDLS 
      4110       4120       4130       4140       4150
NASVKTTAKD IQQTEQTIEQ KLVQAQNLTQ GWEEIKHLKS ELWIYLQDAD 
      4160       4170       4180       4190       4200
QQLQNMKRRH SELELNIAQN MVSQVKDFVK KLQSKQASVN TIIEKVNKLT 
      4210       4220       4230       4240       4250
KKEESPEHKE INHLNDQWLD LCRQSNNLCL QREEDLQRTR DYHDCMNVVE 
      4260       4270       4280       4290       4300
VFLEKFTTEW DNLARSDAES TAVHLEALKK LALALQERKY AIEDLKDQKQ 
      4310       4320       4330       4340       4350
KMIEHLNLDD KELVKEQTSH LEQRWFQLED LIKRKIQVSV TNLEELNVVQ 
      4360       4370       4380       4390       4400
SRFQELMEWA EEQQPNIAEA LKQSPPPDMA QNLLMDHLAI CSELEAKQML 
      4410       4420       4430       4440       4450
LKSLIKDADR VMADLGLNER QVIQKALSDA QSHVNCLSDL VGQRRKYLNK 
      4460       4470       4480       4490       4500
ALSEKTQFLM AVFQATSQIQ QHERKIMFRE HICLLPDDVS KQVKTCKSAQ 
      4510       4520       4530       4540       4550
ASLKTYQNEV TGLWAQGREL MKEVTEQEKS EVLGKLQELQ SVYDSVLQKC 
      4560       4570       4580       4590       4600
SHRLQELEKN LVSRKHFKED FDKACHWLKQ ADIVTFPEIN LMNESSELHT 
      4610       4620       4630       4640       4650
QLAKYQNILE QSPEYENLLL TLQRTGQTIL PSLNEVDHSY LSEKLNALPR 
      4660       4670       4680       4690       4700
QFNVIVALAK DKFYKVQEAI LARKEYASLI ELTTQSLSEL EAQFLRMSKV 
      4710       4720       4730       4740       4750
PTDLAVEEAL SLQDGCRAIL DEVAGLGEAV DELNQKKEGF RSTGQPWQPD 
      4760       4770       4780       4790       4800
KMLHLVTLYH RLKRQTEQRV SLLEDTTSAY QEHEKMCQQL ERQLKSVKEE 
      4810       4820       4830       4840       4850
QSKVNEETLP AEEKLKMYHS LAGSLQDSGI VLKRVTIHLE DLAPHLDPLA 
      4860       4870       4880       4890       4900
YEKARHQIQS WQGELKLLTS AIGETVTECE SRMVQSIDFQ TEMSRSLDWL 
      4910       4920       4930       4940       4950
RRVKAELSGP VYLDLNLQDI QEEIRKIQIH QEEVQSSLRI MNALSHKEKE 
      4960       4970       4980       4990       5000
KFTKAKELIS ADLEHSLAEL SELDGDIQEA LRTRQATLTE IYSQCQRYYQ 
      5010       5020       5030       5040       5050
VFQAANDWLE DAQELLQLAG NGLDVESAEE NLKSHMEFFS TEDQFHSNLE 
      5060       5070       5080       5090       5100
ELHSLVATLD PLIKPTGKED LEQKVASLEL RSQRMSRDSG AQVDLLQRCT 
      5110       5120       5130       5140       5150
AQWHDYQKAR EEVIELMNDT EKKLSEFSLL KTSSSHEAEE KLSEHKALVS 
      5160       5170       5180       5190       5200
VVNSFHEKIV ALEEKASQLE KTGNDASKAT LSRSMTTVWQ RWTRLRAVAQ 
      5210       5220       5230       5240       5250
DQEKILEDAV DEWTGFNNKV KKATEMIDQL QDKLPGSSAE KASKAELLTL 
      5260       5270       5280       5290       5300
LEYHDTFVLE LEQQQSALGM LRQQTLSMLQ DGAAPTPGEE PPLMQEITAM 
      5310       5320       5330       5340       5350
QDRCLNMQEK VKTNGKLVKQ ELKDREMVET QINSVKCWVQ ETKEYLGNPT 
      5360       5370       5380       5390       5400
IEIDAQLEEL QILLTEATNH RQNIEKMAEE QKEKYLGLYT ILPSELSLQL 
      5410       5420       5430       5440       5450
AEVALDLKIR DQIQDKIKEV EQSKATSQEL SRQIQKLAKD LTTILTKLKA 
      5460       5470       5480       5490       5500
KTDNVVQAKT DQKVLGEELD GCNSKLMELD AAVQKFLEQN GQLGKPLAKK 
      5510       5520       5530       5540       5550
IGKLTELHQQ TIRQAENRLS KLNQAASHLE EYNEMLELIL KWIEKAKVLA 
      5560       5570       5580       5590       5600
HGTIAWNSAS QLREQYILHQ TLLEESKEID SELEAMTEKL QYLTSVYCTE 
      5610       5620       5630       5640       5650
KMSQQVAELG RETEELRQMI KIRLQNLQDA AKDMKKFEAE LKKLQAALEQ 
      5660       5670       5680       5690       5700
AQATLTSPEV GRLSLKEQLS HRQHLLSEME SLKPKVQAVQ LCQSALRIPE 
      5710       5720       5730       5740       5750
DVVASLPLCH AALRLQEEAS RLQHTAIQQC NIMQEAVVQY EQYEQEMKHL 
      5760       5770       5780       5790       5800
QQLIEGAHRE IEDKPVATSN IQELQAQISR HEELAQKIKG YQEQIASLNS 
      5810       5820       5830       5840       5850
KCKMLTMKAK HATMLLTVTE VEGLAEGTED LDGELLPTPS AHPSVVMMTA 
      5860       5870       5880       5890       5900
GRCHTLLSPV TEESGEEGTN SEISSPPACR SPSPVANTDA SVNQDIAYYQ 
      5910       5920       5930       5940       5950
ALSAERLQTD AAKIHPSTSA SQEFYEPGLE PSATAKLGDL QRSWETLKNV 
      5960       5970       5980       5990       6000
ISEKQRTLYE ALERQQKYQD SLQSISTKME AIELKLSESP EPGRSPESQM 
      6010       6020       6030       6040       6050
AEHQALMDEI LMLQDEINEL QSSLAEELVS ESCEADPAEQ LALQSTLTVL 
      6060       6070       6080       6090       6100
AERMSTIRMK ASGKRQLLEE KLNDQLEEQR QEQALQRYRC EADELDSWLL 
      6110       6120       6130       6140       6150
STKATLDTAL SPPKEPMDME AQLMDCQNML VEIEQKVVAL SELSVHNENL 
      6160       6170       6180       6190       6200
LLEGKAHTKD EAEQLAGKLR RLKGSLLELQ RALHDKQLNM QGTAQEKEES 
      6210       6220       6230       6240       6250
DVDLTATQSP GVQEWLAQAR TTWTQQRQSS LQQQKELEQE LAEQKSLLRS 
      6260       6270       6280       6290       6300
VASRGEEILI QHSAAETSGD AGEKPDVLSQ ELGMEGEKSS AEDQMRMKWE 
      6310       6320       6330       6340       6350
SLHQEFSTKQ KLLQNVLEQE QEQVLYSRPN RLLSGVPLYK GDVPTQDKSA 
      6360       6370       6380       6390       6400
VTSLLDGLNQ AFEEVSSQSG GAKRQSIHLE QKLYDGVSAT STWLDDVEER 
      6410       6420       6430       6440       6450
LFVATALLPE ETETCLFNQE ILAKDIKEMS EEMDKNKNLF SQAFPENGDN 
      6460       6470       6480       6490       6500
RDVIEDTLGC LLGRLSLLDS VVNQRCHQMK ERLQQILNFQ NDLKVLFTSL 
      6510       6520       6530       6540       6550
ADNKYIILQK LANVFEQPVA EQIEAIQQAE DGLKEFDAGI IELKRRGDKL 
      6560       6570       6580       6590       6600
QVEQPSMQEL SKLQDMYDEL MMIIGSRRSG LNQNLTLKSQ YERALQDLAD 
      6610       6620       6630       6640       6650
LLETGQEKMA GDQKIIVSSK EEIQQLLDKH KEYFQGLESH MILTETLFRK 
      6660       6670       6680       6690       6700
IISFAVQKET QFHTELMAQA SAVLKRAHKR GVELEYILET WSHLDEDQQE 
      6710       6720       6730       6740       6750
LSRQLEVVES SIPSVGLVEE NEDRLIDRIT LYQHLKSSLN EYQPKLYQVL 
      6760       6770       6780       6790       6800
DDGKRLLISI SCSDLESQLN QLGECWLSNT NKMSKELHRL ETILKHWTRY 
      6810       6820       6830       6840       6850
QSESADLIHW LQSAKDRLEF WTQQSVTVPQ ELEMVRDHLN AFLEFSKEVD 
      6860       6870       6880       6890       6900
AQSSLKSSVL STGNQLLRLK KVDTATLRSE LSRIDSQWTD LLTNIPAVQE 
      6910       6920       6930       6940       6950
KLHQLQMDKL PSRHAISEVM SWISLMENVI QKDEDNIKNS IGYKAIHEYL 
      6960       6970       6980       6990       7000
QKYKGFKIDI NCKQLTVDFV NQSVLQISSQ DVESKRSDKT DFAEQLGAMN 
      7010       7020       7030       7040       7050
KSWQILQGLV TEKIQLLEGL LESWSEYENN VQCLKTWFET QEKRLKQQHR 
      7060       7070       7080       7090       7100
IGDQASVQNA LKDCQDLEDL IKAKEKEVEK IEQNGLALIQ NKKEDVSSIV 
      7110       7120       7130       7140       7150
MSTLRELGQT WANLDHMVGQ LKILLKSVLD QWSSHKVAFD KINSYLMEAR 
      7160       7170       7180       7190       7200
YSLSRFRLLT GSLEAVQVQV DNLQNLQDDL EKQERSLQKF GSITNQLLKE 
      7210       7220       7230       7240       7250
CHPPVTETLT NTLKEVNMRW NNLLEEIAEQ LQSSKALLQL WQRYKDYSKQ 
      7260       7270       7280       7290       7300
CASTVQQQED RTNELLKAAT NKDIADDEVA TWIQDCNDLL KGLGTVKDSL 
      7310       7320       7330       7340       7350
FFLHELGEQL KQQVDASAAS AIQSDQLSLS QHLCALEQAL CKQQTSLQAG 
      7360       7370       7380       7390       7400
VLDYETFAKS LEALEAWIVE AEEILQGQDP SHSSDLSTIQ ERMEELKGQM 
      7410       7420       7430       7440       7450
LKFSSMAPDL DRLNELGYRL PLNDKEIKRM QNLNRHWSLI SSQTTERFSK 
      7460       7470       7480       7490       7500
LQSFLLQHQT FLEKCETWME FLVQTEQKLA VEISGNYQHL LEQQRAHELF 
      7510       7520       7530       7540       7550
QAEMFSRQQI LHSIIIDGQR LLEQGQVDDR DEFNLKLTLL SNQWQGVIRR 
      7560       7570       7580       7590       7600
AQQRRGIIDS QIRQWQRYRE MAEKLRKWLV EVSYLPMSGL GSVPIPLQQA 
      7610       7620       7630       7640       7650
RTLFDEVQFK EKVFLRQQGS YILTVEAGKQ LLLSADSGAE AALQAELAEI 
      7660       7670       7680       7690       7700
QEKWKSASMR LEEQKKKLAF LLKDWEKCEK GIADSLEKLR TFKKKLSQSL 
      7710       7720       7730       7740       7750
PDHHEELHAE QMRCKELENA VGSWTDDLTQ LSLLKDTLSA YISADDISIL 
      7760       7770       7780       7790       7800
NERVELLQRQ WEELCHQLSL RRQQIGERLN EWAVFSEKNK ELCEWLTQME 
      7810       7820       7830       7840       7850
SKVSQNGDIL IEEMIEKLKK DYQEEIAIAQ ENKIQLQQMG ERLAKASHES 
      7860       7870       7880       7890       7900
KASEIEYKLG KVNDRWQHLL DLIAARVKKL KETLVAVQQL DKNMSSLRTW 
      7910       7920       7930       7940       7950
LAHIESELAK PIVYDSCNSE EIQRKLNEQQ ELQRDIEKHS TGVASVLNLC 
      7960       7970       7980       7990       8000
EVLLHDCDAC ATDAECDSIQ QATRNLDRRW RNICAMSMER RLKIEETWRL 
      8010       8020       8030       8040       8050
WQKFLDDYSR FEDWLKSSER TAAFPSSSGV IYTVAKEELK KFEAFQRQVH 
      8060       8070       8080       8090       8100
ECLTQLELIN KQYRRLAREN RTDSACSLKQ MVHEGNQRWD NLQKRVTSIL 
      8110       8120       8130       8140       8150
RRLKHFIGQR EEFETARDSI LVWLTEMDLQ LTNIEHFSEC DVQAKIKQLK 
      8160       8170       8180       8190       8200
AFQQEISLNH NKIEQIIAQG EQLIEKSEPL DAAIIEEELD ELRRYCQEVF 
      8210       8220       8230       8240       8250
GRVERYHKKL IRLPLPDDEH DLSDRELELE DSAALSDLHW HDRSADSLLS 
      8260       8270       8280       8290       8300
PQPSSNLSLS LAQPLRSERS GRDTPASVDS IPLEWDHDYD LSRDLESAMS 
      8310       8320       8330       8340       8350
RALPSEDEEG QDDKDFYLRG AVGLSGDHSA LESQIRQLGK ALDDSRFQIQ 
      8360       8370       8380       8390       8400
QTENIIRSKT PTGPELDTSY KGYMKLLGEC SSSIDSVKRL EHKLKEEEES 
      8410       8420       8430       8440       8450
LPGFVNLHST ETQTAGVIDR WELLQAQALS KELRMKQNLQ KWQQFNSDLN 
      8460       8470       8480       8490       8500
SIWAWLGDTE EELEQLQRLE LSTDIQTIEL QIKKLKELQK AVDHRKAIIL 
      8510       8520       8530       8540       8550
SINLCSPEFT QADSKESRDL QDRLSQMNGR WDRVCSLLEE WRGLLQDALM 
      8560       8570       8580       8590       8600
QCQGFHEMSH GLLLMLENID RRKNEIVPID SNLDAEILQD HHKQLMQIKH 
      8610       8620       8630       8640       8650
ELLESQLRVA SLQDMSCQLL VNAEGTDCLE AKEKVHVIGN RLKLLLKEVS 
      8660       8670       8680       8690       8700
RHIKELEKLL DVSSSQQDLS SWSSADELDT SGSVSPTSGR STPNRQKTPR 
      8710       8720       8730       8740       8750
GKCSLSQPGP SVSSPHSRST KGGSDSSLSE PGPGRSGRGF LFRVLRAALP 
      8760       8770       8780       8790 
LQLLLLLLIG LACLVPMSEE DYSCALSNNF ARSFHPMLRY TNGPPPL
Length:8,797
Mass (Da):1,011,086
Last modified:November 28, 2012 - v4
Checksum:i02A53B8AFBF34A17
GO
Isoform 2 (identifier: Q8NF91-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-5476: Missing.

Show »
Length:3,321
Mass (Da):380,360
Checksum:iDEAC32C9FD296ABD
GO
Isoform 3 (identifier: Q8NF91-3) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-7838: Missing.
     8325-8325: S → SDVMIPESPEAYVKLTENAIKNTS

Show »
Length:982
Mass (Da):112,393
Checksum:i332A6E5ABA5A2248
GO
Isoform 4 (identifier: Q8NF91-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-103: K → KSMHRGSP
     3620-3641: Missing.
     3912-3967: Missing.
     8325-8325: S → SDVMIPESPEAYVKLTENAIKNTS

Show »
Length:8,749
Mass (Da):1,005,239
Checksum:i2D846CDD4BC30A8D
GO
Isoform 5 (identifier: Q8NF91-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1437-1443: DIKTMEM → EYVIDKS
     1444-8797: Missing.

Note: No experimental confirmation available.
Show »
Length:1,443
Mass (Da):167,250
Checksum:i01D6C47A6D74C395
GO
Isoform 6 (identifier: Q8NF91-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1702-1725: LQNEVVSQASFYSKLLQLKESLFS → SSRKCEEGKNKMLFVTVTLFKIIK
     1726-8797: Missing.

Note: No experimental confirmation available.
Show »
Length:1,725
Mass (Da):199,267
Checksum:i1ED934CA22A45E49
GO
Isoform 7 (identifier: Q8NF91-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     5571-5580: TLLEESKEID → VTLGKIIFKK
     5581-8797: Missing.

Note: No experimental confirmation available.
Show »
Length:5,580
Mass (Da):642,672
Checksum:iEEDEA59F5A4DBD2A
GO
Isoform 8 (identifier: Q8NF91-8) [UniParc]FASTAAdd to basket
Also known as: Beta 2

The sequence of this isoform differs from the canonical sequence as follows:
     1-5585: Missing.

Show »
Length:3,212
Mass (Da):367,873
Checksum:i9D23ECB198DE3636
GO
Isoform 9 (identifier: Q8NF91-9) [UniParc]FASTAAdd to basket
Also known as: Alpha 2

The sequence of this isoform differs from the canonical sequence as follows:
     1-7843: Missing.
     7844-7874: AKASHESKASEIEYKLGKVNDRWQHLLDLIA → MVVAEDLSALRMAEDGCVDADLPDCNCDVTR
     8325-8325: S → SDVMIPESPEAYVKLTENAIKNTS

Show »
Length:977
Mass (Da):111,583
Checksum:i621DAF9F731FEC9F
GO
Isoform 10 (identifier: Q8NF91-10) [UniParc]FASTAAdd to basket
Also known as: drop1

The sequence of this isoform differs from the canonical sequence as follows:
     297-313: Missing.
     3049-3049: C → W
     3050-8797: Missing.

Note: Lost in uterus, cervix, kidney, lung, thyroid and pancreas carcinomas, already at early tumor stages.1 Publication
Show »
Length:3,032
Mass (Da):349,010
Checksum:iD13770B93FD427D8
GO
Isoform 11 (identifier: Q8NF91-11) [UniParc]FASTAAdd to basket
Also known as: myne-1, 131kDa

The sequence of this isoform differs from the canonical sequence as follows:
     1-7658: Missing.

Note: Muscle-specific.
Show »
Length:1,139
Mass (Da):131,185
Checksum:iE075A5CDBDAAFC43
GO
Isoform GSRP-56 (identifier: Q8NF91-12) [UniParc]FASTAAdd to basket
Also known as: 56kDa

The sequence of this isoform differs from the canonical sequence as follows:
     1-2918: Missing.
     3325-3394: ALLSVKQEKE...EGALSKWTSY → VCIFTQKYLQ...PGCFPKNKIK
     3395-8797: Missing.

Note: Interacts with TRPV2.1 Publication
Show »
Length:476
Mass (Da):54,914
Checksum:i96F892E4F14839B4
GO

Sequence cautioni

The sequence AAC02992 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH39121 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAM95335 differs from that shown. Contaminating sequence. Sequence of unknown origin.Curated
The sequence BAB71097 differs from that shown. Chimeric cDNA.Curated
The sequence BAC04284 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAD28486 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98F → L in AAN60442 (PubMed:12408964).Curated1
Sequence conflicti494S → P in AAM95335 (PubMed:12808039).Curated1
Sequence conflicti1440T → P in CAD28486 (PubMed:17974005).Curated1
Sequence conflicti3096N → D in BAB71097 (PubMed:14702039).Curated1
Sequence conflicti5526A → T in AAL33798 (PubMed:11792814).Curated1
Sequence conflicti5564E → K in AAL33798 (PubMed:11792814).Curated1
Sequence conflicti5735E → A in AAN03486 (PubMed:15093733).Curated1
Sequence conflicti6549K → E in AAL33798 (PubMed:11792814).Curated1
Sequence conflicti6549K → E in AAN60442 (PubMed:12408964).Curated1
Sequence conflicti6549K → E in AAO27774 (Ref. 6) Curated1
Sequence conflicti6626L → P in AAL33798 (PubMed:11792814).Curated1
Sequence conflicti6626L → P in AAN60442 (PubMed:12408964).Curated1
Sequence conflicti6626L → P in AAO27774 (Ref. 6) Curated1
Sequence conflicti6645E → V in AAL33798 (PubMed:11792814).Curated1
Sequence conflicti6645E → V in AAN60442 (PubMed:12408964).Curated1
Sequence conflicti6645E → V in AAO27774 (Ref. 6) Curated1
Sequence conflicti6923I → T in AAL33798 (PubMed:11792814).Curated1
Sequence conflicti6923I → T in AAN60442 (PubMed:12408964).Curated1
Sequence conflicti6923I → T in AAO27774 (Ref. 6) Curated1
Sequence conflicti6929V → A in AAL33798 (PubMed:11792814).Curated1
Sequence conflicti6929V → A in AAN60442 (PubMed:12408964).Curated1
Sequence conflicti6929V → A in AAO27774 (Ref. 6) Curated1
Sequence conflicti7075E → D in AAL33798 (PubMed:11792814).Curated1
Sequence conflicti7075E → D in AAN60442 (PubMed:12408964).Curated1
Sequence conflicti7075E → D in AAO27774 (Ref. 6) Curated1
Sequence conflicti7091N → T in AAL33798 (PubMed:11792814).Curated1
Sequence conflicti7091N → T in AAN60442 (PubMed:12408964).Curated1
Sequence conflicti7091N → T in AAO27774 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056211655Q → R Found in a patient with mild intellectual disability, spastic paraplegia, axon neuropathy and leukoencephalopathy; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs9397509Ensembl.1
Natural variantiVAR_056212885L → V. Corresponds to variant dbSNP:rs17082709Ensembl.1
Natural variantiVAR_0562131035V → A. Corresponds to variant dbSNP:rs214976Ensembl.1
Natural variantiVAR_0741901062R → S1 Publication1
Natural variantiVAR_0562142030S → G. Corresponds to variant dbSNP:rs35763277Ensembl.1
Natural variantiVAR_0562152795A → V. Corresponds to variant dbSNP:rs214950Ensembl.1
Natural variantiVAR_0705613088A → T Found in a patient with mild intellectual disability, spastic paraplegia, axon neuropathy and leukoencephalopathy; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs398123005Ensembl.1
Natural variantiVAR_0362503671V → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs567753957Ensembl.1
Natural variantiVAR_0562163874K → T. Corresponds to variant dbSNP:rs13210127Ensembl.1
Natural variantiVAR_0705623892L → S Found in a patient with mild intellectual disability, spastic paraplegia, axon neuropathy and leukoencephalopathy; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs180727534Ensembl.1
Natural variantiVAR_0562173954S → T. Corresponds to variant dbSNP:rs7775119Ensembl.1
Natural variantiVAR_0562184060E → D. Corresponds to variant dbSNP:rs4645434Ensembl.1
Natural variantiVAR_0562194121K → N. Corresponds to variant dbSNP:rs28385621Ensembl.1
Natural variantiVAR_0562204121K → R. Corresponds to variant dbSNP:rs9479297Ensembl.1
Natural variantiVAR_0562214203E → K. Corresponds to variant dbSNP:rs2130262Ensembl.1
Natural variantiVAR_0362514210E → D in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0362524223R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs140492158Ensembl.1
Natural variantiVAR_0562224546V → I. Corresponds to variant dbSNP:rs4870093Ensembl.1
Natural variantiVAR_0562234596S → T2 PublicationsCorresponds to variant dbSNP:rs6911096Ensembl.1
Natural variantiVAR_0562244944L → M. Corresponds to variant dbSNP:rs2306916Ensembl.1
Natural variantiVAR_0562255015L → M2 PublicationsCorresponds to variant dbSNP:rs2306916Ensembl.1
Natural variantiVAR_0562265377M → L. Corresponds to variant dbSNP:rs35987150Ensembl.1
Natural variantiVAR_0562275426T → M. Corresponds to variant dbSNP:rs2306914Ensembl.1
Natural variantiVAR_0362535507L → R in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0562286566M → I. Corresponds to variant dbSNP:rs35654757Ensembl.1
Natural variantiVAR_0562296664T → I. Corresponds to variant dbSNP:rs35079654Ensembl.1
Natural variantiVAR_0562306951Q → H. Corresponds to variant dbSNP:rs3945783Ensembl.1
Natural variantiVAR_0562317302F → V4 PublicationsCorresponds to variant dbSNP:rs2147377Ensembl.1
Natural variantiVAR_0562327506S → G. Corresponds to variant dbSNP:rs35763277Ensembl.1
Natural variantiVAR_0629748095R → H in EDMD4. 1 PublicationCorresponds to variant dbSNP:rs119103246Ensembl.1
Natural variantiVAR_0562338161N → H. Corresponds to variant dbSNP:rs36215251Ensembl.1
Natural variantiVAR_0562348168A → S. Corresponds to variant dbSNP:rs17082236Ensembl.1
Natural variantiVAR_0155488323G → A5 PublicationsCorresponds to variant dbSNP:rs2252755Ensembl.1
Natural variantiVAR_0629758387V → L in EDMD4. 1 PublicationCorresponds to variant dbSNP:rs119103247Ensembl.1
Natural variantiVAR_0629768461E → K in EDMD4. 1 PublicationCorresponds to variant dbSNP:rs119103248Ensembl.1
Natural variantiVAR_0362548468R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs143049227Ensembl.1
Natural variantiVAR_0562358687T → I. Corresponds to variant dbSNP:rs35591210Ensembl.1
Natural variantiVAR_0562368741L → M. Corresponds to variant dbSNP:rs2295190Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0071331 – 7843Missing in isoform 9. 1 PublicationAdd BLAST7843
Alternative sequenceiVSP_0071321 – 7838Missing in isoform 3. 1 PublicationAdd BLAST7838
Alternative sequenceiVSP_0574761 – 7658Missing in isoform 11. 1 PublicationAdd BLAST7658
Alternative sequenceiVSP_0071311 – 5585Missing in isoform 8. 1 PublicationAdd BLAST5585
Alternative sequenceiVSP_0071301 – 5476Missing in isoform 2. 1 PublicationAdd BLAST5476
Alternative sequenceiVSP_0574771 – 2918Missing in isoform GSRP-56. 1 PublicationAdd BLAST2918
Alternative sequenceiVSP_007134103K → KSMHRGSP in isoform 4. 1 Publication1
Alternative sequenceiVSP_057478297 – 313Missing in isoform 10. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_0071351437 – 1443DIKTMEM → EYVIDKS in isoform 5. 1 Publication7
Alternative sequenceiVSP_0071361444 – 8797Missing in isoform 5. 1 PublicationAdd BLAST7354
Alternative sequenceiVSP_0071371702 – 1725LQNEV…ESLFS → SSRKCEEGKNKMLFVTVTLF KIIK in isoform 6. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_0071381726 – 8797Missing in isoform 6. 1 PublicationAdd BLAST7072
Alternative sequenceiVSP_0574793049C → W in isoform 10. 1 Publication1
Alternative sequenceiVSP_0574803050 – 8797Missing in isoform 10. 1 PublicationAdd BLAST5748
Alternative sequenceiVSP_0574813325 – 3394ALLSV…KWTSY → VCIFTQKYLQPTEFVFLKIS RLHPPGVMMSHSLHDKSQML CECNAVCLGCTCQRIPESSD PGCFPKNKIK in isoform GSRP-56. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_0574823395 – 8797Missing in isoform GSRP-56. 1 PublicationAdd BLAST5403
Alternative sequenceiVSP_0071393620 – 3641Missing in isoform 4. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_0071403912 – 3967Missing in isoform 4. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_0071415571 – 5580TLLEESKEID → VTLGKIIFKK in isoform 7. 1 Publication10
Alternative sequenceiVSP_0071425581 – 8797Missing in isoform 7. 1 PublicationAdd BLAST3217
Alternative sequenceiVSP_0071437844 – 7874AKASH…LDLIA → MVVAEDLSALRMAEDGCVDA DLPDCNCDVTR in isoform 9. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_0071448325S → SDVMIPESPEAYVKLTENAI KNTS in isoform 3, isoform 4 and isoform 9. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY061755 mRNA. Translation: AAL33798.1.
AY061756 mRNA. Translation: AAL33799.1.
AY184203 mRNA. Translation: AAO27771.1.
AY184206 mRNA. Translation: AAO27774.1.
AF535142 mRNA. Translation: AAN03486.1.
AF444779 mRNA. Translation: AAL38031.1.
FM162565 mRNA. Translation: CAQ57272.1.
AF495910 mRNA. Translation: AAN60442.1.
AL049548 Genomic DNA. No translation available.
AL136079 Genomic DNA. No translation available.
AL589963 Genomic DNA. No translation available.
AL591507 Genomic DNA. No translation available.
AL450401, AL078582, AL138832 Genomic DNA. Translation: CAI40728.1.
AL450401
, AL078582, AL138832, AL357081 Genomic DNA. Translation: CAI40729.1.
AL357081
, AL078582, AL138832, AL450401 Genomic DNA. Translation: CAI41322.1.
AL078582, AL138832, AL450401 Genomic DNA. Translation: CAI42283.1.
AL078582
, AL138832, AL357081, AL450401 Genomic DNA. Translation: CAI42284.1.
AL138832, AL078582, AL450401 Genomic DNA. Translation: CAI42785.1.
AL138832
, AL078582, AL357081, AL450401 Genomic DNA. Translation: CAI42786.1.
KF458330 Genomic DNA. No translation available.
BC039121 mRNA. Translation: AAH39121.1. Different initiation.
AY135172 mRNA. Translation: AAM95335.1. Sequence problems.
AY183142 mRNA. Translation: AAO23669.1.
AK056122 mRNA. Translation: BAB71097.1. Sequence problems.
AK094094 mRNA. Translation: BAC04284.1. Different initiation.
AB051543 mRNA. Translation: BAB21847.1.
AL713682 mRNA. Translation: CAD28486.2. Different initiation.
AB033088 mRNA. Translation: BAA86576.1.
AB018339 mRNA. Translation: BAA34516.2.
AF043290 mRNA. Translation: AAC02992.2. Different initiation.
CCDSiCCDS5235.1. [Q8NF91-4]
CCDS5236.2. [Q8NF91-1]
RefSeqiNP_001334631.1. NM_001347702.1.
NP_149062.1. NM_033071.3.
NP_892006.3. NM_182961.3. [Q8NF91-1]
UniGeneiHs.12967.

Genome annotation databases

EnsembliENST00000367253; ENSP00000356222; ENSG00000131018. [Q8NF91-6]
ENST00000367255; ENSP00000356224; ENSG00000131018. [Q8NF91-1]
ENST00000413186; ENSP00000414510; ENSG00000131018. [Q8NF91-5]
GeneIDi23345.
KEGGihsa:23345.
UCSCiuc003qot.5. human. [Q8NF91-1]
uc003qov.4. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSYNE1_HUMAN
AccessioniPrimary (citable) accession number: Q8NF91
Secondary accession number(s): B3W695
, E7EQI5, H0Y4C0, O94890, Q3ZCV0, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: November 28, 2012
Last modified: July 5, 2017
This is version 166 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families