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Protein

Zinc finger MIZ domain-containing protein 2

Gene

ZMIZ2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri585 – 66278SP-RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MIZ domain-containing protein 2
Alternative name(s):
PIAS-like protein Zimp7
Gene namesi
Name:ZMIZ2
Synonyms:KIAA1886, ZIMP7
ORF Names:HRIHFB2007
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22229. ZMIZ2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: HPA
  • nuclear replication fork Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409851.

Polymorphism and mutation databases

BioMutaiZMIZ2.
DMDMi56404909.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 920920Zinc finger MIZ domain-containing protein 2PRO_0000218989Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki402 – 402Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8NF64.
MaxQBiQ8NF64.
PaxDbiQ8NF64.
PRIDEiQ8NF64.

PTM databases

iPTMnetiQ8NF64.
PhosphoSiteiQ8NF64.

Expressioni

Tissue specificityi

Expressed most abundantly in testis with lower levels in heart, brain, pancreas, prostate and ovary.1 Publication

Gene expression databases

BgeeiQ8NF64.
CleanExiHS_ZMIZ2.
ExpressionAtlasiQ8NF64. baseline and differential.
GenevisibleiQ8NF64. HS.

Organism-specific databases

HPAiHPA040716.

Interactioni

Subunit structurei

Interacts with AR, SMARCA4/BRG1 and SMARCE1/BAF57. Interaction with either SMARCA4 and SMARCE1 enhances AR-mediated transcription.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARSJQ8N5N63EBI-745786,EBI-10266832
ASB13Q8WXK33EBI-10182121,EBI-707573
BANPQ8N9N53EBI-10182121,EBI-744695
C2orf88Q9BSF03EBI-10182121,EBI-744298
CRCPO755753EBI-10182121,EBI-2654687
INTS4Q96HW73EBI-10182121,EBI-5663129
NBL1P412713EBI-10182121,EBI-10208650
PIN1Q135264EBI-745786,EBI-714158
SALL2Q9Y4673EBI-10182121,EBI-746180
SCAMP1O151263EBI-10182121,EBI-954338
SELVP597973EBI-10182121,EBI-10216195
SSX2BQ163853EBI-10182121,EBI-2210673
TRAPPC6AO758653EBI-10182121,EBI-743573

Protein-protein interaction databases

BioGridi123701. 25 interactions.
IntActiQ8NF64. 14 interactions.
MINTiMINT-1434694.
STRINGi9606.ENSP00000311778.

Structurei

3D structure databases

ProteinModelPortaliQ8NF64.
SMRiQ8NF64. Positions 482-683.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni435 – 50672Interaction with ARAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi47 – 13286Gly-richAdd
BLAST
Compositional biasi147 – 17024Ala-richAdd
BLAST
Compositional biasi201 – 403203Pro-richAdd
BLAST
Compositional biasi725 – 906182Pro-richAdd
BLAST

Domaini

The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein.

Sequence similaritiesi

Contains 1 SP-RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri585 – 66278SP-RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2169. Eukaryota.
ENOG410XQ2E. LUCA.
GeneTreeiENSGT00550000074410.
HOVERGENiHBG056252.
InParanoidiQ8NF64.
OrthoDBiEOG715Q3Q.
PhylomeDBiQ8NF64.
TreeFamiTF316952.

Family and domain databases

InterProiIPR004181. Znf_MIZ.
[Graphical view]
PfamiPF02891. zf-MIZ. 1 hit.
[Graphical view]
PROSITEiPS51044. ZF_SP_RING. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NF64-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSMNPMKPA LPPAPHGDGS FAYESVPWQQ SATQPAGSLS VVTTVWGVGN
60 70 80 90 100
ATQSQVLGNP MGPAGSPSGS SMMPGVAGGS SALTSPQCLG QQAFAEGGAN
110 120 130 140 150
KGYVQQGVYS RGGYPGAPGF TTGYAGGPGG LGLPSHAARP STDFTQAAAA
160 170 180 190 200
AAVAAAAATA TATATATVAA LQEKQSQELS QYGAMGAGQS FNSQFLQHGG
210 220 230 240 250
PRGPSVPAGM NPTGIGGVMG PSGLSPLAMN PTRAAGMTPL YAGQRLPQHG
260 270 280 290 300
YPGPPQAQPL PRQGVKRTYS EVYPGQQYLQ GGQYAPSTAQ FAPSPGQPPA
310 320 330 340 350
PSPSYPGHRL PLQQGMTQSL SVPGPTGLHY KPTEQFNGQG ASFNGGSVSY
360 370 380 390 400
SQPGLSGPTR SIPGYPSSPL PGNPTPPMTP SSSVPYMSPN QEVKSPFLPD
410 420 430 440 450
LKPNLNSLHS SPSGSGPCDE LRLTFPVRDG VVLEPFRLQH NLAVSNHVFQ
460 470 480 490 500
LRDSVYKTLI MRPDLELQFK CYHHEDRQMN TNWPASVQVS VNATPLTIER
510 520 530 540 550
GDNKTSHKPL YLKHVCQPGR NTIQITVTAC CCSHLFVLQL VHRPSVRSVL
560 570 580 590 600
QGLLKKRLLP AEHCITKIKR NFSSGTIPGT PGPNGEDGVE QTAIKVSLKC
610 620 630 640 650
PITFRRIQLP ARGHDCRHIQ CFDLESYLQL NCERGTWRCP VCNKTALLEG
660 670 680 690 700
LEVDQYMLGI LIYIQNSDYE EITIDPTCSW KPVPVKPDMH IKEEPDGPAL
710 720 730 740 750
KRCRTVSPAH VLMPSVMEMI AALGPGAAPF APLQPPSVPA PSDYPGQGSS
760 770 780 790 800
FLGPGTFPES FPPTTPSTPT LAEFTPGPPP ISYQSDIPSS LLTSEKSTAC
810 820 830 840 850
LPSQMAPAGH LDPTHNPGTP GLHTSNLGAP PGPQLHHSNP PPASRQSLGQ
860 870 880 890 900
ASLGPTGELA FSPATGVMGP PSMSGAGEAP EPALDLLPEL TNPDELLSYL
910 920
GPPDLPTNNN DDLLSLFENN
Length:920
Mass (Da):96,537
Last modified:December 7, 2004 - v2
Checksum:iC9CE99D0B0798B9F
GO
Isoform 2 (identifier: Q8NF64-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     334-359: Missing.

Show »
Length:894
Mass (Da):93,981
Checksum:i3E9DFD0FD14F5CAE
GO
Isoform 3 (identifier: Q8NF64-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-87: Missing.
     334-359: Missing.

Note: No experimental confirmation available.
Show »
Length:862
Mass (Da):91,112
Checksum:i274013C6083F6D2F
GO

Sequence cautioni

The sequence AAH21924.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC03396.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAB66507.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271Missing in AAR85526 (PubMed:16051670).Curated
Sequence conflicti462 – 4621R → RR in CAH56269 (PubMed:11230166).Curated
Sequence conflicti568 – 5681Missing (PubMed:16051670).Curated
Sequence conflicti765 – 7651T → M (PubMed:16051670).Curated
Sequence conflicti765 – 7651T → M (PubMed:15489334).Curated
Sequence conflicti765 – 7651T → M in CAB66507 (PubMed:11230166).Curated
Sequence conflicti782 – 7821S → C (PubMed:9853615).Curated
Sequence conflicti799 – 7991A → V (PubMed:9853615).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti408 – 4081L → F.1 Publication
Corresponds to variant rs3735478 [ dbSNP | Ensembl ].
VAR_050536

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei56 – 8732Missing in isoform 3. 1 PublicationVSP_024918Add
BLAST
Alternative sequencei334 – 35926Missing in isoform 2 and isoform 3. 3 PublicationsVSP_012190Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY426594 mRNA. Translation: AAR85526.1.
AK090415 mRNA. Translation: BAC03396.1. Different initiation.
AC004859 Genomic DNA. No translation available.
AC013436 Genomic DNA. Translation: AAP22368.1. Sequence problems.
CH236960 Genomic DNA. Translation: EAL23750.1.
CH471128 Genomic DNA. Translation: EAW61083.1.
CH471128 Genomic DNA. Translation: EAW61084.1.
CH471128 Genomic DNA. Translation: EAW61085.1.
BC021924 mRNA. Translation: AAH21924.1. Different initiation.
BC110435 mRNA. Translation: AAI10436.1.
AB067473 mRNA. Translation: BAB67779.1.
AL831933 mRNA. Translation: CAH56269.1.
AL136572 mRNA. Translation: CAB66507.1. Different initiation.
AB015330 mRNA. Translation: BAA34789.1.
CCDSiCCDS43576.1. [Q8NF64-1]
CCDS43577.1. [Q8NF64-2]
CCDS75591.1. [Q8NF64-3]
RefSeqiNP_001287888.1. NM_001300959.1. [Q8NF64-3]
NP_113637.3. NM_031449.3. [Q8NF64-1]
NP_777589.2. NM_174929.2. [Q8NF64-2]
XP_005249926.1. XM_005249869.2. [Q8NF64-1]
XP_005249929.1. XM_005249872.2. [Q8NF64-2]
UniGeneiHs.600681.
Hs.77978.

Genome annotation databases

EnsembliENST00000265346; ENSP00000265346; ENSG00000122515. [Q8NF64-2]
ENST00000309315; ENSP00000311778; ENSG00000122515. [Q8NF64-1]
ENST00000413916; ENSP00000409648; ENSG00000122515. [Q8NF64-3]
ENST00000441627; ENSP00000414723; ENSG00000122515. [Q8NF64-1]
GeneIDi83637.
KEGGihsa:83637.
UCSCiuc003tlq.4. human. [Q8NF64-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY426594 mRNA. Translation: AAR85526.1.
AK090415 mRNA. Translation: BAC03396.1. Different initiation.
AC004859 Genomic DNA. No translation available.
AC013436 Genomic DNA. Translation: AAP22368.1. Sequence problems.
CH236960 Genomic DNA. Translation: EAL23750.1.
CH471128 Genomic DNA. Translation: EAW61083.1.
CH471128 Genomic DNA. Translation: EAW61084.1.
CH471128 Genomic DNA. Translation: EAW61085.1.
BC021924 mRNA. Translation: AAH21924.1. Different initiation.
BC110435 mRNA. Translation: AAI10436.1.
AB067473 mRNA. Translation: BAB67779.1.
AL831933 mRNA. Translation: CAH56269.1.
AL136572 mRNA. Translation: CAB66507.1. Different initiation.
AB015330 mRNA. Translation: BAA34789.1.
CCDSiCCDS43576.1. [Q8NF64-1]
CCDS43577.1. [Q8NF64-2]
CCDS75591.1. [Q8NF64-3]
RefSeqiNP_001287888.1. NM_001300959.1. [Q8NF64-3]
NP_113637.3. NM_031449.3. [Q8NF64-1]
NP_777589.2. NM_174929.2. [Q8NF64-2]
XP_005249926.1. XM_005249869.2. [Q8NF64-1]
XP_005249929.1. XM_005249872.2. [Q8NF64-2]
UniGeneiHs.600681.
Hs.77978.

3D structure databases

ProteinModelPortaliQ8NF64.
SMRiQ8NF64. Positions 482-683.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123701. 25 interactions.
IntActiQ8NF64. 14 interactions.
MINTiMINT-1434694.
STRINGi9606.ENSP00000311778.

PTM databases

iPTMnetiQ8NF64.
PhosphoSiteiQ8NF64.

Polymorphism and mutation databases

BioMutaiZMIZ2.
DMDMi56404909.

Proteomic databases

EPDiQ8NF64.
MaxQBiQ8NF64.
PaxDbiQ8NF64.
PRIDEiQ8NF64.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265346; ENSP00000265346; ENSG00000122515. [Q8NF64-2]
ENST00000309315; ENSP00000311778; ENSG00000122515. [Q8NF64-1]
ENST00000413916; ENSP00000409648; ENSG00000122515. [Q8NF64-3]
ENST00000441627; ENSP00000414723; ENSG00000122515. [Q8NF64-1]
GeneIDi83637.
KEGGihsa:83637.
UCSCiuc003tlq.4. human. [Q8NF64-1]

Organism-specific databases

CTDi83637.
GeneCardsiZMIZ2.
H-InvDBHIX0006652.
HGNCiHGNC:22229. ZMIZ2.
HPAiHPA040716.
MIMi611196. gene.
neXtProtiNX_Q8NF64.
PharmGKBiPA162409851.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2169. Eukaryota.
ENOG410XQ2E. LUCA.
GeneTreeiENSGT00550000074410.
HOVERGENiHBG056252.
InParanoidiQ8NF64.
OrthoDBiEOG715Q3Q.
PhylomeDBiQ8NF64.
TreeFamiTF316952.

Miscellaneous databases

ChiTaRSiZMIZ2. human.
GeneWikiiZMIZ2.
GenomeRNAii83637.
PROiQ8NF64.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NF64.
CleanExiHS_ZMIZ2.
ExpressionAtlasiQ8NF64. baseline and differential.
GenevisibleiQ8NF64. HS.

Family and domain databases

InterProiIPR004181. Znf_MIZ.
[Graphical view]
PfamiPF02891. zf-MIZ. 1 hit.
[Graphical view]
PROSITEiPS51044. ZF_SP_RING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes."
    Huang C.-Y., Beliakoff J., Li X., Lee J., Li X., Sharma M., Lim B., Sun Z.
    Mol. Endocrinol. 19:2915-2929(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH AR; SMARCA4 AND SMARCE1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PHE-408.
    Tissue: Spleen.
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 316-920 (ISOFORM 1).
    Tissue: Kidney and Uterus.
  7. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 240-920 (ISOFORM 2).
    Tissue: Brain.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 332-920.
    Tissue: Amygdala and Fetal brain.
  9. "Selection system for genes encoding nuclear-targeted proteins."
    Ueki N., Oda T., Kondo M., Yano K., Noguchi T., Muramatsu M.-A.
    Nat. Biotechnol. 16:1338-1342(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 668-920, SUBCELLULAR LOCATION.
    Tissue: Fetal brain.
  10. "SUMO-2 orchestrates chromatin modifiers in response to DNA damage."
    Hendriks I.A., Treffers L.W., Verlaan-de Vries M., Olsen J.V., Vertegaal A.C.
    Cell Rep. 10:1778-1791(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-402, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZMIZ2_HUMAN
AccessioniPrimary (citable) accession number: Q8NF64
Secondary accession number(s): A4D2K7
, D3DVL1, O94790, Q0VGB4, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: June 8, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.