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Protein

F-box only protein 22

Gene

FBXO22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.1 Publication

GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 22
Alternative name(s):
F-box protein FBX22p44
Gene namesi
Name:FBXO22
Synonyms:FBX22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:13593. FBXO22.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167196.
PharmGKBiPA28035.

Polymorphism and mutation databases

BioMutaiFBXO22.
DMDMi30580428.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199061 – 403F-box only protein 22Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei128PhosphoserineCombined sources1
Modified residuei194N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8NEZ5.
MaxQBiQ8NEZ5.
PaxDbiQ8NEZ5.
PeptideAtlasiQ8NEZ5.
PRIDEiQ8NEZ5.

PTM databases

iPTMnetiQ8NEZ5.
PhosphoSitePlusiQ8NEZ5.

Expressioni

Tissue specificityi

Predominantly expressed in liver, also enriched in cardiac muscle.1 Publication

Gene expression databases

BgeeiENSG00000167196.
CleanExiHS_FBXO22.
ExpressionAtlasiQ8NEZ5. baseline and differential.
GenevisibleiQ8NEZ5. HS.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SKP1P632084EBI-2510137,EBI-307486

Protein-protein interaction databases

BioGridi117649. 11 interactors.
IntActiQ8NEZ5. 7 interactors.
STRINGi9606.ENSP00000307833.

Structurei

3D structure databases

ProteinModelPortaliQ8NEZ5.
SMRiQ8NEZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 67F-boxAdd BLAST47

Sequence similaritiesi

Contains 1 F-box domain.Curated

Phylogenomic databases

eggNOGiENOG410IQPW. Eukaryota.
ENOG4110X7S. LUCA.
GeneTreeiENSGT00390000013049.
HOGENOMiHOG000285967.
HOVERGENiHBG051570.
InParanoidiQ8NEZ5.
KOiK10302.
OMAiCCKVGAS.
OrthoDBiEOG091G08DL.
PhylomeDBiQ8NEZ5.
TreeFamiTF328809.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR019494. FIST_C.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF10442. FIST_C. 1 hit.
[Graphical view]
SMARTiSM01204. FIST_C. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NEZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPVGCCGEC RGSSVDPRST FVLSNLAEVV ERVLTFLPAK ALLRVACVCR
60 70 80 90 100
LWRECVRRVL RTHRSVTWIS AGLAEAGHLE GHCLVRVVAE ELENVRILPH
110 120 130 140 150
TVLYMADSET FISLEECRGH KRARKRTSME TALALEKLFP KQCQVLGIVT
160 170 180 190 200
PGIVVTPMGS GSNRPQEIEI GESGFALLFP QIEGIKIQPF HFIKDPKNLT
210 220 230 240 250
LERHQLTEVG LLDNPELRVV LVFGYNCCKV GASNYLQQVV STFSDMNIIL
260 270 280 290 300
AGGQVDNLSS LTSEKNPLDI DASGVVGLSF SGHRIQSATV LLNEDVSDEK
310 320 330 340 350
TAEAAMQRLK AANIPEHNTI GFMFACVGRG FQYYRAKGNV EADAFRKFFP
360 370 380 390 400
SVPLFGFFGN GEIGCDRIVT GNFILRKCNE VKDDDLFHSY TTIMALIHLG

SSK
Length:403
Mass (Da):44,508
Last modified:October 1, 2002 - v1
Checksum:iD96712BAA1149D8D
GO
Isoform 2 (identifier: Q8NEZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-403: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:46
Mass (Da):4,922
Checksum:i1D49258F07775FA2
GO
Isoform 3 (identifier: Q8NEZ5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-276: NPLDIDASGVV → YVLCASDFVCE
     277-403: Missing.

Note: No experimental confirmation available.
Show »
Length:276
Mass (Da):30,589
Checksum:i0E9B0CE3E208358B
GO

Sequence cautioni

The sequence AAH39024 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4 – 11VGCCGECR → AGACGGP in AAF04523 (PubMed:10531035).Curated8
Sequence conflicti349F → L in AAH32540 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04182147 – 403Missing in isoform 2. 1 PublicationAdd BLAST357
Alternative sequenceiVSP_013058266 – 276NPLDIDASGVV → YVLCASDFVCE in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_013059277 – 403Missing in isoform 3. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY005144 mRNA. Translation: AAF89095.1.
AK024048 mRNA. Translation: BAB14798.1.
AC027104 Genomic DNA. No translation available.
BC032540 mRNA. Translation: AAH32540.1.
BC020204 mRNA. Translation: AAH20204.2.
BC039024 mRNA. Translation: AAH39024.1. Sequence problems.
BC041691 mRNA. Translation: AAH41691.1.
AF174602 Genomic DNA. Translation: AAF04523.1.
CCDSiCCDS10287.1. [Q8NEZ5-1]
CCDS45310.1. [Q8NEZ5-3]
RefSeqiNP_036302.1. NM_012170.3. [Q8NEZ5-3]
NP_671717.1. NM_147188.2. [Q8NEZ5-1]
XP_011519749.1. XM_011521447.2.
UniGeneiHs.591115.

Genome annotation databases

EnsembliENST00000308275; ENSP00000307833; ENSG00000167196. [Q8NEZ5-1]
ENST00000453211; ENSP00000396442; ENSG00000167196. [Q8NEZ5-3]
ENST00000569022; ENSP00000457531; ENSG00000167196. [Q8NEZ5-2]
GeneIDi26263.
KEGGihsa:26263.
UCSCiuc002bbj.3. human. [Q8NEZ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY005144 mRNA. Translation: AAF89095.1.
AK024048 mRNA. Translation: BAB14798.1.
AC027104 Genomic DNA. No translation available.
BC032540 mRNA. Translation: AAH32540.1.
BC020204 mRNA. Translation: AAH20204.2.
BC039024 mRNA. Translation: AAH39024.1. Sequence problems.
BC041691 mRNA. Translation: AAH41691.1.
AF174602 Genomic DNA. Translation: AAF04523.1.
CCDSiCCDS10287.1. [Q8NEZ5-1]
CCDS45310.1. [Q8NEZ5-3]
RefSeqiNP_036302.1. NM_012170.3. [Q8NEZ5-3]
NP_671717.1. NM_147188.2. [Q8NEZ5-1]
XP_011519749.1. XM_011521447.2.
UniGeneiHs.591115.

3D structure databases

ProteinModelPortaliQ8NEZ5.
SMRiQ8NEZ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117649. 11 interactors.
IntActiQ8NEZ5. 7 interactors.
STRINGi9606.ENSP00000307833.

PTM databases

iPTMnetiQ8NEZ5.
PhosphoSitePlusiQ8NEZ5.

Polymorphism and mutation databases

BioMutaiFBXO22.
DMDMi30580428.

Proteomic databases

EPDiQ8NEZ5.
MaxQBiQ8NEZ5.
PaxDbiQ8NEZ5.
PeptideAtlasiQ8NEZ5.
PRIDEiQ8NEZ5.

Protocols and materials databases

DNASUi26263.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308275; ENSP00000307833; ENSG00000167196. [Q8NEZ5-1]
ENST00000453211; ENSP00000396442; ENSG00000167196. [Q8NEZ5-3]
ENST00000569022; ENSP00000457531; ENSG00000167196. [Q8NEZ5-2]
GeneIDi26263.
KEGGihsa:26263.
UCSCiuc002bbj.3. human. [Q8NEZ5-1]

Organism-specific databases

CTDi26263.
GeneCardsiFBXO22.
HGNCiHGNC:13593. FBXO22.
MIMi609096. gene.
neXtProtiNX_Q8NEZ5.
OpenTargetsiENSG00000167196.
PharmGKBiPA28035.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQPW. Eukaryota.
ENOG4110X7S. LUCA.
GeneTreeiENSGT00390000013049.
HOGENOMiHOG000285967.
HOVERGENiHBG051570.
InParanoidiQ8NEZ5.
KOiK10302.
OMAiCCKVGAS.
OrthoDBiEOG091G08DL.
PhylomeDBiQ8NEZ5.
TreeFamiTF328809.

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii26263.
PROiQ8NEZ5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167196.
CleanExiHS_FBXO22.
ExpressionAtlasiQ8NEZ5. baseline and differential.
GenevisibleiQ8NEZ5. HS.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR019494. FIST_C.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF10442. FIST_C. 1 hit.
[Graphical view]
SMARTiSM01204. FIST_C. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFBX22_HUMAN
AccessioniPrimary (citable) accession number: Q8NEZ5
Secondary accession number(s): Q0D2P8
, Q6PIL5, Q8IXW3, Q9H824, Q9UKC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.