Q8NEZ4 (MLL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone-lysine N-methyltransferase MLL3
EC=2.1.1.43

Alternative name(s):
Homologous to ALR protein
Lysine N-methyltransferase 2C
Short name=KMT2C
Myeloid/lymphoid or mixed-lineage leukemia protein 3

Gene names

Name:	MLL3
Synonyms:	HALR, KIAA1506, KMT2C

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	4911 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/MLL3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder. Ref.16
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. Ref.16
Subunit structure	Component of the MLL2/MLL3 complex (also named ASCOM complex), at least composed of MLL2, MLL3, ASH2L, RBBP5, DPY30, NCOA6, WDR5, MEN1, KDM6A and PAXIP1/PTIP. Component of the MLL3/MLL4 complex at least composed of MLL3, MLL4, ASH2L, RBBP5, DPY30, WDR5, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1. Interacts with histone H3. Ref.8
Subcellular location	Nucleus Probable.
Tissue specificity	Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver.
Domain	The SET domain interacts with histone H3 but not H2A, H2B and H4, and may have a H3 lysine specific methylation activity.
Miscellaneous	Found in a critical region of chromosome 7, which is commonly deleted in malignant myeloid disorders. Partial duplication of the MLL3 gene are found in the juxtacentromeric region of chromosomes 1, 2, 13 and 21. Juxtacentromeric reshuffling of the MLL3 gene has generated the BAGE genes.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily. Contains 1 A.T hook DNA-binding domain. Contains 1 DHHC-type zinc finger. Contains 1 FYR C-terminal domain. Contains 1 FYR N-terminal domain. Contains 6 PHD-type zinc fingers. Contains 1 post-SET domain. Contains 1 RING-type zinc finger. Contains 1 SET domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat Zinc-finger
Ligand	DNA-binding Metal-binding S-adenosyl-L-methionine Zinc
Molecular function	Activator Chromatin regulator Methyltransferase Transferase
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NCOA6	Q14686	4	EBI-1042997,EBI-78670

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NEZ4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NEZ4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-939: Missing.
     3890-3890: Q → QVRQLSLLPLMEPIIGVNFAHFLPYGSGQFNSGNRLLGTFGSATLEGVSDYYSQLIYK
     4721-4724: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8NEZ4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     3890-3890: Q → QVRQLSLLPLMEPIIGVNFAHFLPYGSGQFNSGNRLLGTFGSATLEGVSDYYSQLIYK

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 4911

4911

Histone-lysine N-methyltransferase MLL3

PRO_0000124879

Regions

Domain

4545 – 4605

61

FYR N-terminal

Domain

4606 – 4691

86

FYR C-terminal

Domain

4770 – 4891

122

SET

Domain

4895 – 4911

17

Post-SET

DNA binding

34 – 46

13

A.T hook

Zinc finger

341 – 391

51

PHD-type 1

Zinc finger

344 – 389

46

RING-type

Zinc finger

388 – 438

51

PHD-type 2

Zinc finger

436 – 489

54

DHHC-type

Zinc finger

464 – 520

57

PHD-type 3

Zinc finger

957 – 1010

54

PHD-type 4

Zinc finger

1007 – 1057

51

PHD-type 5

Zinc finger

1084 – 1139

56

PHD-type 6

Region

4848 – 4849

2

S-adenosyl-L-methionine binding By similarity

Coiled coil

92 – 112

21

Potential

Coiled coil

644 – 672

29

Potential

Coiled coil

1338 – 1366

29

Potential

Coiled coil

1754 – 1787

34

Potential

Coiled coil

3054 – 3081

28

Potential

Coiled coil

3173 – 3272

100

Potential

Coiled coil

3391 – 3433

43

Potential

Compositional bias

1719 – 1796

78

Gln-rich

Compositional bias

1834 – 2281

448

Pro-rich

Compositional bias

2412 – 2630

219

Pro-rich

Compositional bias

2690 – 2786

97

Asp-rich

Compositional bias

3012 – 3509

498

Gln-rich

Compositional bias

3277 – 3381

105

Pro-rich

Sites

Metal binding

4851

1

Zinc By similarity

Metal binding

4899

1

Zinc By similarity

Metal binding

4901

1

Zinc By similarity

Metal binding

4906

1

Zinc By similarity

Binding site

4825

1

S-adenosyl-L-methionine By similarity

Amino acid modifications

Modified residue

758

1

N6-acetyllysine Ref.12

Modified residue

827

1

N6-acetyllysine Ref.12

Modified residue

1508

1

N6-acetyllysine Ref.12

Modified residue

1772

1

N6-acetyllysine Ref.12

Modified residue

2009

1

N6-acetyllysine Ref.12

Modified residue

2802

1

N6-acetyllysine Ref.12

Modified residue

2809

1

N6-acetyllysine Ref.10 Ref.12

Modified residue

2832

1

N6-acetyllysine Ref.12

Modified residue

3714

1

N6-acetyllysine Ref.12

Modified residue

3945

1

N6-acetyllysine Ref.12

Modified residue

4018

1

Phosphotyrosine Ref.9

Modified residue

4022

1

Phosphoserine Ref.9

Modified residue

4034

1

Phosphoserine Ref.11

Modified residue

4050

1

Phosphoserine Ref.11

Natural variations

Alternative sequence

1 – 939

939

Missing in isoform 2.

VSP_008561

Alternative sequence

3890

1

Q → QVRQLSLLPLMEPIIGVNFA HFLPYGSGQFNSGNRLLGTF GSATLEGVSDYYSQLIYK in isoform 2 and isoform 3.

VSP_008562

Alternative sequence

4721 – 4724

4

Missing in isoform 2.

VSP_036223

Natural variant

291

1

L → F.
Corresponds to variant rs56850341 [ dbSNP | Ensembl ].

VAR_061911

Natural variant

316

1

T → S.
Corresponds to variant rs10454320 [ dbSNP | Ensembl ].

VAR_061912

Natural variant

347

1

C → G in a colorectal cancer sample; somatic mutation. Ref.15

VAR_036311

Natural variant

400

1

D → N in a colorectal cancer sample; somatic mutation. Ref.15

VAR_036312

Natural variant

478

1

L → W in a colorectal cancer sample; somatic mutation. Ref.15

VAR_036313

Natural variant

526

1

R → P. Ref.1
Corresponds to variant rs3735156 [ dbSNP | Ensembl ].

VAR_057360

Natural variant

823

1

I → N.
Corresponds to variant rs2838171 [ dbSNP | Ensembl ].

VAR_017118

Natural variant

823

1

I → T.
Corresponds to variant rs2838171 [ dbSNP | Ensembl ].

VAR_017117

Natural variant

1836

1

S → N.
Corresponds to variant rs11771635 [ dbSNP | Ensembl ].

VAR_057361

Natural variant

2008

1

T → A.
Corresponds to variant rs6951159 [ dbSNP | Ensembl ].

VAR_057362

Natural variant

2412

1

P → T.
Corresponds to variant rs13231116 [ dbSNP | Ensembl ].

VAR_057363

Natural variant

2600

1

P → A.
Corresponds to variant rs2270234 [ dbSNP | Ensembl ].

VAR_057364

Natural variant

3698

1

T → S in a colorectal cancer sample; somatic mutation. Ref.15

VAR_036314

Experimental info

Sequence conflict

579

1

A → T in AAK00583. Ref.1

Sequence conflict

1286

1

M → V in AAK00583. Ref.1

Sequence conflict

2360

1

P → S in AAK00583. Ref.1

Sequence conflict

2797

1

K → R in AAK00583. Ref.1

Sequence conflict

2882

1

T → A in AAK00583. Ref.1

Sequence conflict

3289

1

P → S in BAC11409. Ref.6

Sequence conflict

3428

1

R → W in BAC11409. Ref.6

Sequence conflict

4613

1

I → V in AK022687. Ref.6

Sequence conflict

4866

1

H → P in AK022687. Ref.6

Secondary structure

1

.

.

.

.

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.

.

.

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.

.

.

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.

.

.

.

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.

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.

.

.

.

.

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4911

Helix Strand Turn

Details...

Turn

345 – 347

3

Turn

353 – 355

3

Beta strand

356 – 358

3

Beta strand

360 – 362

3

Turn

368 – 372

5

Turn

377 – 379

3

Turn

386 – 388

3

Turn

392 – 394

3

Beta strand

403 – 405

3

Beta strand

407 – 409

3

Beta strand

412 – 414

3

Helix

415 – 417

3

Beta strand

418 – 420

3

Helix

433 – 436

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 20, 2009. Version 3. Checksum: 898CEE324772BD75	FASTA	4,911	541,370
	10 20 30 40 50 60 MSSEEDKSVE QPQPPPPPPE EPGAPAPSPA AADKRPRGRP RKDGASPFQR ARKKPRSRGK 70 80 90 100 110 120 TAVEDEDSMD GLETTETETI VETEIKEQSA EEDAEAEVDN SKQLIPTLQR SVSEESANSL 130 140 150 160 170 180 VSVGVEAKIS EQLCAFCYCG EKSSLGQGDL KQFRITPGFI LPWRNQPSNK KDIDDNSNGT 190 200 210 220 230 240 YEKMQNSAPR KQRGQRKERS PQQNIVSCVS VSTQTASDDQ AGKLWDELSL VGLPDAIDIQ 250 260 270 280 290 300 ALFDSTGTCW AHHRCVEWSL GVCQMEEPLL VNVDKAVVSG STERCAFCKH LGATIKCCEE 310 320 330 340 350 360 KCTQMYHYPC AAGAGTFQDF SHIFLLCPEH IDQAPERSKE DANCAVCDSP GDLLDQFFCT 370 380 390 400 410 420 TCGQHYHGMC LDIAVTPLKR AGWQCPECKV CQNCKQSGED SKMLVCDTCD KGYHTFCLQP 430 440 450 460 470 480 VMKSVPTNGW KCKNCRICIE CGTRSSSQWH HNCLICDNCY QQQDNLCPFC GKCYHPELQK 490 500 510 520 530 540 DMLHCNMCKR WVHLECDKPT DHELDTQLKE EYICMYCKHL GAEMDRLQPG EEVEIAELTT 550 560 570 580 590 600 DYNNEMEVEG PEDQMVFSEQ AANKDVNGQE STPGIVPDAV QVHTEEQQKS HPSESLDTDS 610 620 630 640 650 660 LLIAVSSQHT VNTELEKQIS NEVDSEDLKM SSEVKHICGE DQIEDKMEVT ENIEVVTHQI 670 680 690 700 710 720 TVQQEQLQLL EEPETVVSRE ESRPPKLVME SVTLPLETLV SPHEESISLC PEEQLVIERL 730 740 750 760 770 780 QGEKEQKENS ELSTGLMDSE MTPTIEGCVK DVSYQGGKSI KLSSETESSF SSSADISKAD 790 800 810 820 830 840 VSSSPTPSSD LPSHDMLHNY PSALSSSAGN IMPTTYISVT PKIGMGKPAI TKRKFSPGRP 850 860 870 880 890 900 RSKQGAWSTH NTVSPPSWSP DISEGREIFK PRQLPGSAIW SIKVGRGSGF PGKRRPRGAG 910 920 930 940 950 960 LSGRGGRGRS KLKSGIGAVV LPGVSTADIS SNKDDEENSM HNTVVLFSSS DKFTLNQDMC 970 980 990 1000 1010 1020 VVCGSFGQGA EGRLLACSQC GQCYHPYCVS IKITKVVLSK GWRCLECTVC EACGKATDPG 1030 1040 1050 1060 1070 1080 RLLLCDDCDI SYHTYCLDPP LQTVPKGGWK CKWCVWCRHC GATSAGLRCE WQNNYTQCAP 1090 1100 1110 1120 1130 1140 CASLSSCPVC YRNYREEDLI LQCRQCDRWM HAVCQNLNTE EEVENVADIG FDCSMCRPYM 1150 1160 1170 1180 1190 1200 PASNVPSSDC CESSLVAQIV TKVKELDPPK TYTQDGVCLT ESGMTQLQSL TVTVPRRKRS 1210 1220 1230 1240 1250 1260 KPKLKLKIIN QNSVAVLQTP PDIQSEHSRD GEMDDSREGE LMDCDGKSES SPEREAVDDE 1270 1280 1290 1300 1310 1320 TKGVEGTDGV KKRKRKPYRP GIGGFMVRQR SRTGQGKTKR SVIRKDSSGS ISEQLPCRDD 1330 1340 1350 1360 1370 1380 GWSEQLPDTL VDESVSVTES TEKIKKRYRK RKNKLEETFP AYLQEAFFGK DLLDTSRQSK 1390 1400 1410 1420 1430 1440 ISLDNLSEDG AQLLYKTNMN TGFLDPSLDP LLSSSSAPTK SGTHGPADDP LADISEVLNT 1450 1460 1470 1480 1490 1500 DDDILGIISD DLAKSVDHSD IGPVTDDPSS LPQPNVNQSS RPLSEEQLDG ILSPELDKMV 1510 1520 1530 1540 1550 1560 TDGAILGKLY KIPELGGKDV EDLFTAVLSP ANTQPTPLPQ PPPPTQLLPI HNQDAFSRMP 1570 1580 1590 1600 1610 1620 LMNGLIGSSP HLPHNSLPPG SGLGTFSAIA QSSYPDARDK NSAFNPMASD PNNSWTSSAP 1630 1640 1650 1660 1670 1680 TVEGENDTMS NAQRSTLKWE KEEALGEMAT VAPVLYTNIN FPNLKEEFPD WTTRVKQIAK 1690 1700 1710 1720 1730 1740 LWRKASSQER APYVQKARDN RAALRINKVQ MSNDSMKRQQ QQDSIDPSSR IDSELFKDPL 1750 1760 1770 1780 1790 1800 KQRESEHEQE WKFRQQMRQK SKQQAKIEAT QKLEQVKNEQ QQQQQQQFGS QHLLVQSGSD 1810 1820 1830 1840 1850 1860 TPSSGIQSPL TPQPGNGNMS PAQSFHKELF TKQPPSTPTS TSSDDVFVKP QAPPPPPAPS 1870 1880 1890 1900 1910 1920 RIPIQDSLSQ AQTSQPPSPQ VFSPGSSNSR PPSPMDPYAK MVGTPRPPPV GHSFSRRNSA 1930 1940 1950 1960 1970 1980 APVENCTPLS SVSRPLQMNE TTANRPSPVR DLCSSSTTNN DPYAKPPDTP RPVMTDQFPK 1990 2000 2010 2020 2030 2040 SLGLSRSPVV SEQTAKGPIA AGTSDHFTKP SPRADVFQRQ RIPDSYARPL LTPAPLDSGP 2050 2060 2070 2080 2090 2100 GPFKTPMQPP PSSQDPYGSV SQASRRLSVD PYERPALTPR PIDNFSHNQS NDPYSQPPLT 2110 2120 2130 2140 2150 2160 PHPAVNESFA HPSRAFSQPG TISRPTSQDP YSQPPGTPRP VVDSYSQSSG TARSNTDPYS 2170 2180 2190 2200 2210 2220 QPPGTPRPTT VDPYSQQPQT PRPSTQTDLF VTPVTNQRHS DPYAHPPGTP RPGISVPYSQ 2230 2240 2250 2260 2270 2280 PPATPRPRIS EGFTRSSMTR PVLMPNQDPF LQAAQNRGPA LPGPLVRPPD TCSQTPRPPG 2290 2300 2310 2320 2330 2340 PGLSDTFSRV SPSAARDPYD QSPMTPRSQS DSFGTSQTAH DVADQPRPGS EGSFCASSNS 2350 2360 2370 2380 2390 2400 PMHSQGQQFS GVSQLPGPVP TSGVTDTQNT VNMAQADTEK LRQRQKLREI ILQQQQQKKI 2410 2420 2430 2440 2450 2460 AGRQEKGSQD SPAVPHPGPL QHWQPENVNQ AFTRPPPPYP GNIRSPVAPP LGPRYAVFPK 2470 2480 2490 2500 2510 2520 DQRGPYPPDV ASMGMRPHGF RFGFPGGSHG TMPSQERFLV PPQQIQGSGV SPQLRRSVSV 2530 2540 2550 2560 2570 2580 DMPRPLNNSQ MNNPVGLPQH FSPQSLPVQQ HNILGQAYIE LRHRAPDGRQ RLPFSAPPGS 2590 2600 2610 2620 2630 2640 VVEASSNLRH GNFIPRPDFP GPRHTDPMRR PPQGLPNQLP VHPDLEQVPP SQQEQGHSVH 2650 2660 2670 2680 2690 2700 SSSMVMRTLN HPLGGEFSEA PLSTSVPSET TSDNLQITTQ PSDGLEEKLD SDDPSVKELD 2710 2720 2730 2740 2750 2760 VKDLEGVEVK DLDDEDLENL NLDTEDGKVV ELDTLDNLET NDPNLDDLLR SGEFDIIAYT 2770 2780 2790 2800 2810 2820 DPELDMGDKK SMFNEELDLP IDDKLDNQCV SVEPKKKEQE NKTLVLSDKH SPQKKSTVTN 2830 2840 2850 2860 2870 2880 EVKTEVLSPN SKVESKCETE KNDENKDNVD TPCSQASAHS DLNDGEKTSL HPCDPDLFEK 2890 2900 2910 2920 2930 2940 RTNRETAGPS ANVIQASTQL PAQDVINSCG ITGSTPVLSS LLANEKSDNS DIRPSGSPPP 2950 2960 2970 2980 2990 3000 PTLPASPSNH VSSLPPFIAP PGRVLDNAMN SNVTVVSRVN HVFSQGVQVN PGLIPGQSTV 3010 3020 3030 3040 3050 3060 NHSLGTGKPA TQTGPQTSQS GTSSMSGPQQ LMIPQTLAQQ NRERPLLLEE QPLLLQDLLD 3070 3080 3090 3100 3110 3120 QERQEQQQQR QMQAMIRQRS EPFFPNIDFD AITDPIMKAK MVALKGINKV MAQNNLGMPP 3130 3140 3150 3160 3170 3180 MVMSRFPFMG QVVTGTQNSE GQNLGPQAIP QDGSITHQIS RPNPPNFGPG FVNDSQRKQY 3190 3200 3210 3220 3230 3240 EEWLQETQQL LQMQQKYLEE QIGAHRKSKK ALSAKQRTAK KAGREFPEED AEQLKHVTEQ 3250 3260 3270 3280 3290 3300 QSMVQKQLEQ IRKQQKEHAE LIEDYRIKQQ QQCAMAPPTM MPSVQPQPPL IPGATPPTMS 3310 3320 3330 3340 3350 3360 QPTFPMVPQQ LQHQQHTTVI SGHTSPVRMP SLPGWQPNSA PAHLPLNPPR IQPPIAQLPI 3370 3380 3390 3400 3410 3420 KTCTPAPGTV SNANPQSGPP PRVEFDDNNP FSESFQERER KERLREQQER QRIQLMQEVD 3430 3440 3450 3460 3470 3480 RQRALQQRME MEQHGMVGSE ISSSRTSVSQ IPFYSSDLPC DFMQPLGPLQ QSPQHQQQMG 3490 3500 3510 3520 3530 3540 QVLQQQNIQQ GSINSPSTQT FMQTNERRQV GPPSFVPDSP SIPVGSPNFS SVKQGHGNLS 3550 3560 3570 3580 3590 3600 GTSFQQSPVR PSFTPALPAA PPVANSSLPC GQDSTITHGH SYPGSTQSLI QLYSDIIPEE 3610 3620 3630 3640 3650 3660 KGKKKRTRKK KRDDDAESTK APSTPHSDIT APPTPGISET TSTPAVSTPS ELPQQADQES 3670 3680 3690 3700 3710 3720 VEPVGPSTPN MAAGQLCTEL ENKLPNSDFS QATPNQQTYA NSEVDKLSME TPAKTEEIKL 3730 3740 3750 3760 3770 3780 EKAETESCPG QEEPKLEEQN GSKVEGNAVA CPVSSAQSPP HSAGAPAAKG DSGNELLKHL 3790 3800 3810 3820 3830 3840 LKNKKSSSLL NQKPEGSICS EDDCTKDNKL VEKQNPAEGL QTLGAQMQGG FGCGNQLPKT 3850 3860 3870 3880 3890 3900 DGGSETKKQR SKRTQRTGEK AAPRSKKRKK DEEEKQAMYS STDTFTHLKQ QNNLSNPPTP 3910 3920 3930 3940 3950 3960 PASLPPTPPP MACQKMANGF ATTEELAGKA GVLVSHEVTK TLGPKPFQLP FRPQDDLLAR 3970 3980 3990 4000 4010 4020 ALAQGPKTVD VPASLPTPPH NNQEELRIQD HCGDRDTPDS FVPSSSPESV VGVEVSRYPD 4030 4040 4050 4060 4070 4080 LSLVKEEPPE PVPSPIIPIL PSTAGKSSES RRNDIKTEPG TLYFASPFGP SPNGPRSGLI 4090 4100 4110 4120 4130 4140 SVAITLHPTA AENISSVVAA FSDLLHVRIP NSYEVSSAPD VPSMGLVSSH RINPGLEYRQ 4150 4160 4170 4180 4190 4200 HLLLRGPPPG SANPPRLVSS YRLKQPNVPF PPTSNGLSGY KDSSHGIAES AALRPQWCCH 4210 4220 4230 4240 4250 4260 CKVVILGSGV RKSFKDLTLL NKDSRESTKR VEKDIVFCSN NCFILYSSTA QAKNSENKES 4270 4280 4290 4300 4310 4320 IPSLPQSPMR ETPSKAFHQY SNNISTLDVH CLPQLPEKAS PPASPPIAFP PAFEAAQVEA 4330 4340 4350 4360 4370 4380 KPDELKVTVK LKPRLRAVHG GFEDCRPLNK KWRGMKWKKW SIHIVIPKGT FKPPCEDEID 4390 4400 4410 4420 4430 4440 EFLKKLGTSL KPDPVPKDYR KCCFCHEEGD GLTDGPARLL NLDLDLWVHL NCALWSTEVY 4450 4460 4470 4480 4490 4500 ETQAGALINV ELALRRGLQM KCVFCHKTGA TSGCHRFRCT NIYHFTCAIK AQCMFFKDKT 4510 4520 4530 4540 4550 4560 MLCPMHKPKG IHEQELSYFA VFRRVYVQRD EVRQIASIVQ RGERDHTFRV GSLIFHTIGQ 4570 4580 4590 4600 4610 4620 LLPQQMQAFH SPKALFPVGY EASRLYWSTR YANRRCRYLC SIEEKDGRPV FVIRIVEQGH 4630 4640 4650 4660 4670 4680 EDLVLSDISP KGVWDKILEP VACVRKKSEM LQLFPAYLKG EDLFGLTVSA VARIAESLPG 4690 4700 4710 4720 4730 4740 VEACENYTFR YGRNPLMELP LAVNPTGCAR SEPKMSAHVK RFVLRPHTLN STSTSKSFQS 4750 4760 4770 4780 4790 4800 TVTGELNAPY SKQFVHSKSS QYRKMKTEWK SNVYLARSRI QGLGLYAARD IEKHTMVIEY 4810 4820 4830 4840 4850 4860 IGTIIRNEVA NRKEKLYESQ NRGVYMFRMD NDHVIDATLT GGPARYINHS CAPNCVAEVV 4870 4880 4890 4900 4910 TFERGHKIII SSSRRIQKGE ELCYDYKFDF EDDQHKIPCH CGAVNCRKWM N
	Isoform 2 [UniParc]. Checksum: 41624149C28E4BDE	FASTA	4,025	443,538
	10 20 30 40 50 60 MHNTVVLFSS SDKFTLNQDM CVVCGSFGQG AEGRLLACSQ CGQCYHPYCV SIKITKVVLS 70 80 90 100 110 120 KGWRCLECTV CEACGKATDP GRLLLCDDCD ISYHTYCLDP PLQTVPKGGW KCKWCVWCRH 130 140 150 160 170 180 CGATSAGLRC EWQNNYTQCA PCASLSSCPV CYRNYREEDL ILQCRQCDRW MHAVCQNLNT 190 200 210 220 230 240 EEEVENVADI GFDCSMCRPY MPASNVPSSD CCESSLVAQI VTKVKELDPP KTYTQDGVCL 250 260 270 280 290 300 TESGMTQLQS LTVTVPRRKR SKPKLKLKII NQNSVAVLQT PPDIQSEHSR DGEMDDSREG 310 320 330 340 350 360 ELMDCDGKSE SSPEREAVDD ETKGVEGTDG VKKRKRKPYR PGIGGFMVRQ RSRTGQGKTK 370 380 390 400 410 420 RSVIRKDSSG SISEQLPCRD DGWSEQLPDT LVDESVSVTE STEKIKKRYR KRKNKLEETF 430 440 450 460 470 480 PAYLQEAFFG KDLLDTSRQS KISLDNLSED GAQLLYKTNM NTGFLDPSLD PLLSSSSAPT 490 500 510 520 530 540 KSGTHGPADD PLADISEVLN TDDDILGIIS DDLAKSVDHS DIGPVTDDPS SLPQPNVNQS 550 560 570 580 590 600 SRPLSEEQLD GILSPELDKM VTDGAILGKL YKIPELGGKD VEDLFTAVLS PANTQPTPLP 610 620 630 640 650 660 QPPPPTQLLP IHNQDAFSRM PLMNGLIGSS PHLPHNSLPP GSGLGTFSAI AQSSYPDARD 670 680 690 700 710 720 KNSAFNPMAS DPNNSWTSSA PTVEGENDTM SNAQRSTLKW EKEEALGEMA TVAPVLYTNI 730 740 750 760 770 780 NFPNLKEEFP DWTTRVKQIA KLWRKASSQE RAPYVQKARD NRAALRINKV QMSNDSMKRQ 790 800 810 820 830 840 QQQDSIDPSS RIDSELFKDP LKQRESEHEQ EWKFRQQMRQ KSKQQAKIEA TQKLEQVKNE 850 860 870 880 890 900 QQQQQQQQFG SQHLLVQSGS DTPSSGIQSP LTPQPGNGNM SPAQSFHKEL FTKQPPSTPT 910 920 930 940 950 960 STSSDDVFVK PQAPPPPPAP SRIPIQDSLS QAQTSQPPSP QVFSPGSSNS RPPSPMDPYA 970 980 990 1000 1010 1020 KMVGTPRPPP VGHSFSRRNS AAPVENCTPL SSVSRPLQMN ETTANRPSPV RDLCSSSTTN 1030 1040 1050 1060 1070 1080 NDPYAKPPDT PRPVMTDQFP KSLGLSRSPV VSEQTAKGPI AAGTSDHFTK PSPRADVFQR 1090 1100 1110 1120 1130 1140 QRIPDSYARP LLTPAPLDSG PGPFKTPMQP PPSSQDPYGS VSQASRRLSV DPYERPALTP 1150 1160 1170 1180 1190 1200 RPIDNFSHNQ SNDPYSQPPL TPHPAVNESF AHPSRAFSQP GTISRPTSQD PYSQPPGTPR 1210 1220 1230 1240 1250 1260 PVVDSYSQSS GTARSNTDPY SQPPGTPRPT TVDPYSQQPQ TPRPSTQTDL FVTPVTNQRH 1270 1280 1290 1300 1310 1320 SDPYAHPPGT PRPGISVPYS QPPATPRPRI SEGFTRSSMT RPVLMPNQDP FLQAAQNRGP 1330 1340 1350 1360 1370 1380 ALPGPLVRPP DTCSQTPRPP GPGLSDTFSR VSPSAARDPY DQSPMTPRSQ SDSFGTSQTA 1390 1400 1410 1420 1430 1440 HDVADQPRPG SEGSFCASSN SPMHSQGQQF SGVSQLPGPV PTSGVTDTQN TVNMAQADTE 1450 1460 1470 1480 1490 1500 KLRQRQKLRE IILQQQQQKK IAGRQEKGSQ DSPAVPHPGP LQHWQPENVN QAFTRPPPPY 1510 1520 1530 1540 1550 1560 PGNIRSPVAP PLGPRYAVFP KDQRGPYPPD VASMGMRPHG FRFGFPGGSH GTMPSQERFL 1570 1580 1590 1600 1610 1620 VPPQQIQGSG VSPQLRRSVS VDMPRPLNNS QMNNPVGLPQ HFSPQSLPVQ QHNILGQAYI 1630 1640 1650 1660 1670 1680 ELRHRAPDGR QRLPFSAPPG SVVEASSNLR HGNFIPRPDF PGPRHTDPMR RPPQGLPNQL 1690 1700 1710 1720 1730 1740 PVHPDLEQVP PSQQEQGHSV HSSSMVMRTL NHPLGGEFSE APLSTSVPSE TTSDNLQITT 1750 1760 1770 1780 1790 1800 QPSDGLEEKL DSDDPSVKEL DVKDLEGVEV KDLDDEDLEN LNLDTEDGKV VELDTLDNLE 1810 1820 1830 1840 1850 1860 TNDPNLDDLL RSGEFDIIAY TDPELDMGDK KSMFNEELDL PIDDKLDNQC VSVEPKKKEQ 1870 1880 1890 1900 1910 1920 ENKTLVLSDK HSPQKKSTVT NEVKTEVLSP NSKVESKCET EKNDENKDNV DTPCSQASAH 1930 1940 1950 1960 1970 1980 SDLNDGEKTS LHPCDPDLFE KRTNRETAGP SANVIQASTQ LPAQDVINSC GITGSTPVLS 1990 2000 2010 2020 2030 2040 SLLANEKSDN SDIRPSGSPP PPTLPASPSN HVSSLPPFIA PPGRVLDNAM NSNVTVVSRV 2050 2060 2070 2080 2090 2100 NHVFSQGVQV NPGLIPGQST VNHSLGTGKP ATQTGPQTSQ SGTSSMSGPQ QLMIPQTLAQ 2110 2120 2130 2140 2150 2160 QNRERPLLLE EQPLLLQDLL DQERQEQQQQ RQMQAMIRQR SEPFFPNIDF DAITDPIMKA 2170 2180 2190 2200 2210 2220 KMVALKGINK VMAQNNLGMP PMVMSRFPFM GQVVTGTQNS EGQNLGPQAI PQDGSITHQI 2230 2240 2250 2260 2270 2280 SRPNPPNFGP GFVNDSQRKQ YEEWLQETQQ LLQMQQKYLE EQIGAHRKSK KALSAKQRTA 2290 2300 2310 2320 2330 2340 KKAGREFPEE DAEQLKHVTE QQSMVQKQLE QIRKQQKEHA ELIEDYRIKQ QQQCAMAPPT 2350 2360 2370 2380 2390 2400 MMPSVQPQPP LIPGATPPTM SQPTFPMVPQ QLQHQQHTTV ISGHTSPVRM PSLPGWQPNS 2410 2420 2430 2440 2450 2460 APAHLPLNPP RIQPPIAQLP IKTCTPAPGT VSNANPQSGP PPRVEFDDNN PFSESFQERE 2470 2480 2490 2500 2510 2520 RKERLREQQE RQRIQLMQEV DRQRALQQRM EMEQHGMVGS EISSSRTSVS QIPFYSSDLP 2530 2540 2550 2560 2570 2580 CDFMQPLGPL QQSPQHQQQM GQVLQQQNIQ QGSINSPSTQ TFMQTNERRQ VGPPSFVPDS 2590 2600 2610 2620 2630 2640 PSIPVGSPNF SSVKQGHGNL SGTSFQQSPV RPSFTPALPA APPVANSSLP CGQDSTITHG 2650 2660 2670 2680 2690 2700 HSYPGSTQSL IQLYSDIIPE EKGKKKRTRK KKRDDDAEST KAPSTPHSDI TAPPTPGISE 2710 2720 2730 2740 2750 2760 TTSTPAVSTP SELPQQADQE SVEPVGPSTP NMAAGQLCTE LENKLPNSDF SQATPNQQTY 2770 2780 2790 2800 2810 2820 ANSEVDKLSM ETPAKTEEIK LEKAETESCP GQEEPKLEEQ NGSKVEGNAV ACPVSSAQSP 2830 2840 2850 2860 2870 2880 PHSAGAPAAK GDSGNELLKH LLKNKKSSSL LNQKPEGSIC SEDDCTKDNK LVEKQNPAEG 2890 2900 2910 2920 2930 2940 LQTLGAQMQG GFGCGNQLPK TDGGSETKKQ RSKRTQRTGE KAAPRSKKRK KDEEEKQAMY 2950 2960 2970 2980 2990 3000 SSTDTFTHLK QVRQLSLLPL MEPIIGVNFA HFLPYGSGQF NSGNRLLGTF GSATLEGVSD 3010 3020 3030 3040 3050 3060 YYSQLIYKQN NLSNPPTPPA SLPPTPPPMA CQKMANGFAT TEELAGKAGV LVSHEVTKTL 3070 3080 3090 3100 3110 3120 GPKPFQLPFR PQDDLLARAL AQGPKTVDVP ASLPTPPHNN QEELRIQDHC GDRDTPDSFV 3130 3140 3150 3160 3170 3180 PSSSPESVVG VEVSRYPDLS LVKEEPPEPV PSPIIPILPS TAGKSSESRR NDIKTEPGTL 3190 3200 3210 3220 3230 3240 YFASPFGPSP NGPRSGLISV AITLHPTAAE NISSVVAAFS DLLHVRIPNS YEVSSAPDVP 3250 3260 3270 3280 3290 3300 SMGLVSSHRI NPGLEYRQHL LLRGPPPGSA NPPRLVSSYR LKQPNVPFPP TSNGLSGYKD 3310 3320 3330 3340 3350 3360 SSHGIAESAA LRPQWCCHCK VVILGSGVRK SFKDLTLLNK DSRESTKRVE KDIVFCSNNC 3370 3380 3390 3400 3410 3420 FILYSSTAQA KNSENKESIP SLPQSPMRET PSKAFHQYSN NISTLDVHCL PQLPEKASPP 3430 3440 3450 3460 3470 3480 ASPPIAFPPA FEAAQVEAKP DELKVTVKLK PRLRAVHGGF EDCRPLNKKW RGMKWKKWSI 3490 3500 3510 3520 3530 3540 HIVIPKGTFK PPCEDEIDEF LKKLGTSLKP DPVPKDYRKC CFCHEEGDGL TDGPARLLNL 3550 3560 3570 3580 3590 3600 DLDLWVHLNC ALWSTEVYET QAGALINVEL ALRRGLQMKC VFCHKTGATS GCHRFRCTNI 3610 3620 3630 3640 3650 3660 YHFTCAIKAQ CMFFKDKTML CPMHKPKGIH EQELSYFAVF RRVYVQRDEV RQIASIVQRG 3670 3680 3690 3700 3710 3720 ERDHTFRVGS LIFHTIGQLL PQQMQAFHSP KALFPVGYEA SRLYWSTRYA NRRCRYLCSI 3730 3740 3750 3760 3770 3780 EEKDGRPVFV IRIVEQGHED LVLSDISPKG VWDKILEPVA CVRKKSEMLQ LFPAYLKGED 3790 3800 3810 3820 3830 3840 LFGLTVSAVA RIAESLPGVE ACENYTFRYG RNPLMELPLA VNPTGCARSE PKMSAHVKRP 3850 3860 3870 3880 3890 3900 HTLNSTSTSK SFQSTVTGEL NAPYSKQFVH SKSSQYRKMK TEWKSNVYLA RSRIQGLGLY 3910 3920 3930 3940 3950 3960 AARDIEKHTM VIEYIGTIIR NEVANRKEKL YESQNRGVYM FRMDNDHVID ATLTGGPARY 3970 3980 3990 4000 4010 4020 INHSCAPNCV AEVVTFERGH KIIISSSRRI QKGEELCYDY KFDFEDDQHK IPCHCGAVNC RKWMN
	Isoform 3 [UniParc]. Checksum: 7D6E36D9FA78714B	FASTA	4,968	547,633
	10 20 30 40 50 60 MSSEEDKSVE QPQPPPPPPE EPGAPAPSPA AADKRPRGRP RKDGASPFQR ARKKPRSRGK 70 80 90 100 110 120 TAVEDEDSMD GLETTETETI VETEIKEQSA EEDAEAEVDN SKQLIPTLQR SVSEESANSL 130 140 150 160 170 180 VSVGVEAKIS EQLCAFCYCG EKSSLGQGDL KQFRITPGFI LPWRNQPSNK KDIDDNSNGT 190 200 210 220 230 240 YEKMQNSAPR KQRGQRKERS PQQNIVSCVS VSTQTASDDQ AGKLWDELSL VGLPDAIDIQ 250 260 270 280 290 300 ALFDSTGTCW AHHRCVEWSL GVCQMEEPLL VNVDKAVVSG STERCAFCKH LGATIKCCEE 310 320 330 340 350 360 KCTQMYHYPC AAGAGTFQDF SHIFLLCPEH IDQAPERSKE DANCAVCDSP GDLLDQFFCT 370 380 390 400 410 420 TCGQHYHGMC LDIAVTPLKR AGWQCPECKV CQNCKQSGED SKMLVCDTCD KGYHTFCLQP 430 440 450 460 470 480 VMKSVPTNGW KCKNCRICIE CGTRSSSQWH HNCLICDNCY QQQDNLCPFC GKCYHPELQK 490 500 510 520 530 540 DMLHCNMCKR WVHLECDKPT DHELDTQLKE EYICMYCKHL GAEMDRLQPG EEVEIAELTT 550 560 570 580 590 600 DYNNEMEVEG PEDQMVFSEQ AANKDVNGQE STPGIVPDAV QVHTEEQQKS HPSESLDTDS 610 620 630 640 650 660 LLIAVSSQHT VNTELEKQIS NEVDSEDLKM SSEVKHICGE DQIEDKMEVT ENIEVVTHQI 670 680 690 700 710 720 TVQQEQLQLL EEPETVVSRE ESRPPKLVME SVTLPLETLV SPHEESISLC PEEQLVIERL 730 740 750 760 770 780 QGEKEQKENS ELSTGLMDSE MTPTIEGCVK DVSYQGGKSI KLSSETESSF SSSADISKAD 790 800 810 820 830 840 VSSSPTPSSD LPSHDMLHNY PSALSSSAGN IMPTTYISVT PKIGMGKPAI TKRKFSPGRP 850 860 870 880 890 900 RSKQGAWSTH NTVSPPSWSP DISEGREIFK PRQLPGSAIW SIKVGRGSGF PGKRRPRGAG 910 920 930 940 950 960 LSGRGGRGRS KLKSGIGAVV LPGVSTADIS SNKDDEENSM HNTVVLFSSS DKFTLNQDMC 970 980 990 1000 1010 1020 VVCGSFGQGA EGRLLACSQC GQCYHPYCVS IKITKVVLSK GWRCLECTVC EACGKATDPG 1030 1040 1050 1060 1070 1080 RLLLCDDCDI SYHTYCLDPP LQTVPKGGWK CKWCVWCRHC GATSAGLRCE WQNNYTQCAP 1090 1100 1110 1120 1130 1140 CASLSSCPVC YRNYREEDLI LQCRQCDRWM HAVCQNLNTE EEVENVADIG FDCSMCRPYM 1150 1160 1170 1180 1190 1200 PASNVPSSDC CESSLVAQIV TKVKELDPPK TYTQDGVCLT ESGMTQLQSL TVTVPRRKRS 1210 1220 1230 1240 1250 1260 KPKLKLKIIN QNSVAVLQTP PDIQSEHSRD GEMDDSREGE LMDCDGKSES SPEREAVDDE 1270 1280 1290 1300 1310 1320 TKGVEGTDGV KKRKRKPYRP GIGGFMVRQR SRTGQGKTKR SVIRKDSSGS ISEQLPCRDD 1330 1340 1350 1360 1370 1380 GWSEQLPDTL VDESVSVTES TEKIKKRYRK RKNKLEETFP AYLQEAFFGK DLLDTSRQSK 1390 1400 1410 1420 1430 1440 ISLDNLSEDG AQLLYKTNMN TGFLDPSLDP LLSSSSAPTK SGTHGPADDP LADISEVLNT 1450 1460 1470 1480 1490 1500 DDDILGIISD DLAKSVDHSD IGPVTDDPSS LPQPNVNQSS RPLSEEQLDG ILSPELDKMV 1510 1520 1530 1540 1550 1560 TDGAILGKLY KIPELGGKDV EDLFTAVLSP ANTQPTPLPQ PPPPTQLLPI HNQDAFSRMP 1570 1580 1590 1600 1610 1620 LMNGLIGSSP HLPHNSLPPG SGLGTFSAIA QSSYPDARDK NSAFNPMASD PNNSWTSSAP 1630 1640 1650 1660 1670 1680 TVEGENDTMS NAQRSTLKWE KEEALGEMAT VAPVLYTNIN FPNLKEEFPD WTTRVKQIAK 1690 1700 1710 1720 1730 1740 LWRKASSQER APYVQKARDN RAALRINKVQ MSNDSMKRQQ QQDSIDPSSR IDSELFKDPL 1750 1760 1770 1780 1790 1800 KQRESEHEQE WKFRQQMRQK SKQQAKIEAT QKLEQVKNEQ QQQQQQQFGS QHLLVQSGSD 1810 1820 1830 1840 1850 1860 TPSSGIQSPL TPQPGNGNMS PAQSFHKELF TKQPPSTPTS TSSDDVFVKP QAPPPPPAPS 1870 1880 1890 1900 1910 1920 RIPIQDSLSQ AQTSQPPSPQ VFSPGSSNSR PPSPMDPYAK MVGTPRPPPV GHSFSRRNSA 1930 1940 1950 1960 1970 1980 APVENCTPLS SVSRPLQMNE TTANRPSPVR DLCSSSTTNN DPYAKPPDTP RPVMTDQFPK 1990 2000 2010 2020 2030 2040 SLGLSRSPVV SEQTAKGPIA AGTSDHFTKP SPRADVFQRQ RIPDSYARPL LTPAPLDSGP 2050 2060 2070 2080 2090 2100 GPFKTPMQPP PSSQDPYGSV SQASRRLSVD PYERPALTPR PIDNFSHNQS NDPYSQPPLT 2110 2120 2130 2140 2150 2160 PHPAVNESFA HPSRAFSQPG TISRPTSQDP YSQPPGTPRP VVDSYSQSSG TARSNTDPYS 2170 2180 2190 2200 2210 2220 QPPGTPRPTT VDPYSQQPQT PRPSTQTDLF VTPVTNQRHS DPYAHPPGTP RPGISVPYSQ 2230 2240 2250 2260 2270 2280 PPATPRPRIS EGFTRSSMTR PVLMPNQDPF LQAAQNRGPA LPGPLVRPPD TCSQTPRPPG 2290 2300 2310 2320 2330 2340 PGLSDTFSRV SPSAARDPYD QSPMTPRSQS DSFGTSQTAH DVADQPRPGS EGSFCASSNS 2350 2360 2370 2380 2390 2400 PMHSQGQQFS GVSQLPGPVP TSGVTDTQNT VNMAQADTEK LRQRQKLREI ILQQQQQKKI 2410 2420 2430 2440 2450 2460 AGRQEKGSQD SPAVPHPGPL QHWQPENVNQ AFTRPPPPYP GNIRSPVAPP LGPRYAVFPK 2470 2480 2490 2500 2510 2520 DQRGPYPPDV ASMGMRPHGF RFGFPGGSHG TMPSQERFLV PPQQIQGSGV SPQLRRSVSV 2530 2540 2550 2560 2570 2580 DMPRPLNNSQ MNNPVGLPQH FSPQSLPVQQ HNILGQAYIE LRHRAPDGRQ RLPFSAPPGS 2590 2600 2610 2620 2630 2640 VVEASSNLRH GNFIPRPDFP GPRHTDPMRR PPQGLPNQLP VHPDLEQVPP SQQEQGHSVH 2650 2660 2670 2680 2690 2700 SSSMVMRTLN HPLGGEFSEA PLSTSVPSET TSDNLQITTQ PSDGLEEKLD SDDPSVKELD 2710 2720 2730 2740 2750 2760 VKDLEGVEVK DLDDEDLENL NLDTEDGKVV ELDTLDNLET NDPNLDDLLR SGEFDIIAYT 2770 2780 2790 2800 2810 2820 DPELDMGDKK SMFNEELDLP IDDKLDNQCV SVEPKKKEQE NKTLVLSDKH SPQKKSTVTN 2830 2840 2850 2860 2870 2880 EVKTEVLSPN SKVESKCETE KNDENKDNVD TPCSQASAHS DLNDGEKTSL HPCDPDLFEK 2890 2900 2910 2920 2930 2940 RTNRETAGPS ANVIQASTQL PAQDVINSCG ITGSTPVLSS LLANEKSDNS DIRPSGSPPP 2950 2960 2970 2980 2990 3000 PTLPASPSNH VSSLPPFIAP PGRVLDNAMN SNVTVVSRVN HVFSQGVQVN PGLIPGQSTV 3010 3020 3030 3040 3050 3060 NHSLGTGKPA TQTGPQTSQS GTSSMSGPQQ LMIPQTLAQQ NRERPLLLEE QPLLLQDLLD 3070 3080 3090 3100 3110 3120 QERQEQQQQR QMQAMIRQRS EPFFPNIDFD AITDPIMKAK MVALKGINKV MAQNNLGMPP 3130 3140 3150 3160 3170 3180 MVMSRFPFMG QVVTGTQNSE GQNLGPQAIP QDGSITHQIS RPNPPNFGPG FVNDSQRKQY 3190 3200 3210 3220 3230 3240 EEWLQETQQL LQMQQKYLEE QIGAHRKSKK ALSAKQRTAK KAGREFPEED AEQLKHVTEQ 3250 3260 3270 3280 3290 3300 QSMVQKQLEQ IRKQQKEHAE LIEDYRIKQQ QQCAMAPPTM MPSVQPQPPL IPGATPPTMS 3310 3320 3330 3340 3350 3360 QPTFPMVPQQ LQHQQHTTVI SGHTSPVRMP SLPGWQPNSA PAHLPLNPPR IQPPIAQLPI 3370 3380 3390 3400 3410 3420 KTCTPAPGTV SNANPQSGPP PRVEFDDNNP FSESFQERER KERLREQQER QRIQLMQEVD 3430 3440 3450 3460 3470 3480 RQRALQQRME MEQHGMVGSE ISSSRTSVSQ IPFYSSDLPC DFMQPLGPLQ QSPQHQQQMG 3490 3500 3510 3520 3530 3540 QVLQQQNIQQ GSINSPSTQT FMQTNERRQV GPPSFVPDSP SIPVGSPNFS SVKQGHGNLS 3550 3560 3570 3580 3590 3600 GTSFQQSPVR PSFTPALPAA PPVANSSLPC GQDSTITHGH SYPGSTQSLI QLYSDIIPEE 3610 3620 3630 3640 3650 3660 KGKKKRTRKK KRDDDAESTK APSTPHSDIT APPTPGISET TSTPAVSTPS ELPQQADQES 3670 3680 3690 3700 3710 3720 VEPVGPSTPN MAAGQLCTEL ENKLPNSDFS QATPNQQTYA NSEVDKLSME TPAKTEEIKL 3730 3740 3750 3760 3770 3780 EKAETESCPG QEEPKLEEQN GSKVEGNAVA CPVSSAQSPP HSAGAPAAKG DSGNELLKHL 3790 3800 3810 3820 3830 3840 LKNKKSSSLL NQKPEGSICS EDDCTKDNKL VEKQNPAEGL QTLGAQMQGG FGCGNQLPKT 3850 3860 3870 3880 3890 3900 DGGSETKKQR SKRTQRTGEK AAPRSKKRKK DEEEKQAMYS STDTFTHLKQ VRQLSLLPLM 3910 3920 3930 3940 3950 3960 EPIIGVNFAH FLPYGSGQFN SGNRLLGTFG SATLEGVSDY YSQLIYKQNN LSNPPTPPAS 3970 3980 3990 4000 4010 4020 LPPTPPPMAC QKMANGFATT EELAGKAGVL VSHEVTKTLG PKPFQLPFRP QDDLLARALA 4030 4040 4050 4060 4070 4080 QGPKTVDVPA SLPTPPHNNQ EELRIQDHCG DRDTPDSFVP SSSPESVVGV EVSRYPDLSL 4090 4100 4110 4120 4130 4140 VKEEPPEPVP SPIIPILPST AGKSSESRRN DIKTEPGTLY FASPFGPSPN GPRSGLISVA 4150 4160 4170 4180 4190 4200 ITLHPTAAEN ISSVVAAFSD LLHVRIPNSY EVSSAPDVPS MGLVSSHRIN PGLEYRQHLL 4210 4220 4230 4240 4250 4260 LRGPPPGSAN PPRLVSSYRL KQPNVPFPPT SNGLSGYKDS SHGIAESAAL RPQWCCHCKV 4270 4280 4290 4300 4310 4320 VILGSGVRKS FKDLTLLNKD SRESTKRVEK DIVFCSNNCF ILYSSTAQAK NSENKESIPS 4330 4340 4350 4360 4370 4380 LPQSPMRETP SKAFHQYSNN ISTLDVHCLP QLPEKASPPA SPPIAFPPAF EAAQVEAKPD 4390 4400 4410 4420 4430 4440 ELKVTVKLKP RLRAVHGGFE DCRPLNKKWR GMKWKKWSIH IVIPKGTFKP PCEDEIDEFL 4450 4460 4470 4480 4490 4500 KKLGTSLKPD PVPKDYRKCC FCHEEGDGLT DGPARLLNLD LDLWVHLNCA LWSTEVYETQ 4510 4520 4530 4540 4550 4560 AGALINVELA LRRGLQMKCV FCHKTGATSG CHRFRCTNIY HFTCAIKAQC MFFKDKTMLC 4570 4580 4590 4600 4610 4620 PMHKPKGIHE QELSYFAVFR RVYVQRDEVR QIASIVQRGE RDHTFRVGSL IFHTIGQLLP 4630 4640 4650 4660 4670 4680 QQMQAFHSPK ALFPVGYEAS RLYWSTRYAN RRCRYLCSIE EKDGRPVFVI RIVEQGHEDL 4690 4700 4710 4720 4730 4740 VLSDISPKGV WDKILEPVAC VRKKSEMLQL FPAYLKGEDL FGLTVSAVAR IAESLPGVEA 4750 4760 4770 4780 4790 4800 CENYTFRYGR NPLMELPLAV NPTGCARSEP KMSAHVKRFV LRPHTLNSTS TSKSFQSTVT 4810 4820 4830 4840 4850 4860 GELNAPYSKQ FVHSKSSQYR KMKTEWKSNV YLARSRIQGL GLYAARDIEK HTMVIEYIGT 4870 4880 4890 4900 4910 4920 IIRNEVANRK EKLYESQNRG VYMFRMDNDH VIDATLTGGP ARYINHSCAP NCVAEVVTFE 4930 4940 4950 4960 RGHKIIISSS RRIQKGEELC YDYKFDFEDD QHKIPCHCGA VNCRKWMN

References

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[1]	"MLL3, a new human member of the TRX/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia." Ruault M., Brun M.-E., Ventura M., Roizes G., De Sario A. Gene 284:73-81(2002) [PubMed: 11891048] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PRO-526. Tissue: Fetal thymus.
[2]	"Novel human HALR (MLL3) gene encodes a protein homologous to ALR and to ALL-1 involved in leukemia, and maps to chromosome 7q36 associated with leukemia and developmental defects." Tan Y.C., Chow V.T. Cancer Detect. Prev. 25:454-469(2001) [PubMed: 11718452] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Cervix carcinoma.
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:143-150(2000) [PubMed: 10819331] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 556-3865 (ISOFORM 1). Tissue: Brain.
[5]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3193-3865 AND 4460-4911. Tissue: Placenta.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Testis.
[8]	"Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins." Goo Y.-H., Sohn Y.C., Kim D.-H., Kim S.-W., Kang M.-J., Jung D.-J., Kwak E., Barlev N.A., Berger S.L., Chow V.T., Roeder R.G., Azorsa D.O., Meltzer P.S., Suh P.-G., Song E.J., Lee K.-J., Lee Y.C., Lee J.W. Mol. Cell. Biol. 23:140-149(2003) [PubMed: 12482968] [Abstract] Cited for: INTERACTION WITH MLL2/MLL3 COMPLEX (ISOFORM 2). Tissue: Cervix carcinoma.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-4018 AND SER-4022, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Substrate and functional diversity of lysine acetylation revealed by a proteomics survey." Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y. Mol. Cell 23:607-618(2006) [PubMed: 16916647] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-2809, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4034 AND SER-4050, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-758; LYS-827; LYS-1508; LYS-1772; LYS-2009; LYS-2802; LYS-2809; LYS-2832; LYS-3714 AND LYS-3945, MASS SPECTROMETRY.
[13]	"Solution structure of the first and second PHD domain from myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 342-439.
[14]	"Solution structure of the HMG box of human myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog." RIKEN structural genomics initiative (RSGI) Submitted (APR-2008) to the PDB data bank Cited for: STRUCTURE BY NMR OF 1624-1713.
[15]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLY-347; ASN-400; TRP-478 AND SER-3698.
[16]	"PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex." Cho Y.-W., Hong T., Hong S., Guo H., Yu H., Kim D., Guszczynski T., Dressler G.R., Copeland T.D., Kalkum M., Ge K. J. Biol. Chem. 282:20395-20406(2007) [PubMed: 17500065] [Abstract] Cited for: FUNCTION, ENZYME ACTIVITY, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MLL3/MLL4 COMPLEX.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY024361 mRNA. Translation: AAK00583.1.
AF264750 mRNA. Translation: AAF74766.2.
AC006017 Genomic DNA. Translation: AAD45822.1.
AC104692 Genomic DNA. No translation available.
AC005631 Genomic DNA. No translation available.
AB040939 mRNA. Translation: BAA96030.2.
AK022687 mRNA. No translation available.
AK075113 mRNA. Translation: BAC11409.1.
AL833924 mRNA. Translation: CAD38780.1.

IPI

IPI00168806.
IPI00375729.
IPI00916332.

RefSeq

NP_733751.2. NM_170606.2.

UniGene

Hs.647120.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2YSM	NMR	-	A	342-439	[»]
2YUK	NMR	-	A	1631-1713	[»]

ProteinModelPortal

Q8NEZ4.

SMR

Q8NEZ4. Positions 282-520, 956-1138, 1624-1713, 4542-4691, 4756-4911.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-48649N.

IntAct

Q8NEZ4. 9 interactions.

STRING

Q8NEZ4.

PTM databases

PhosphoSite

Q8NEZ4.

Polymorphism databases

DMDM

221222521.

Proteomic databases

PRIDE

Q8NEZ4.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000262189; ENSP00000262189; ENSG00000055609.

GeneID

58508.

KEGG

hsa:58508.

UCSC

uc003wla.1. human.

Organism-specific databases

CTD

58508.

GeneCards

GC07M151832.

H-InvDB

HIX0007238.

HGNC

HGNC:13726. MLL3.

MIM

606833. gene.

neXtProt

NX_Q8NEZ4.

PharmGKB

PA30847.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

GeneTree

ENSGT00580000081416.

HOVERGEN

HBG045586.

InParanoid

Q8NEZ4.

OMA

DTSRQNK.

PhylomeDB

Q8NEZ4.

Gene expression databases

ArrayExpress

Q8NEZ4.

Bgee

Q8NEZ4.

CleanEx

HS_MLL3.

Genevestigator

Q8NEZ4.

GermOnline

ENSG00000055609. Homo sapiens.

Family and domain databases

InterPro

IPR017956. AT_hook_DNA-bd_motif.
IPR003889. FYrich_C.
IPR018516. FYrich_C_subgr.
IPR003888. FYrich_N.
IPR018518. FYrich_N_subgr.
IPR000910. HMG_HMG1/HMG2.
IPR000637. HMGI/Y_DNA-bd_CS.
IPR003616. Post-SET_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR001214. SET_dom.
IPR001594. Znf_DHHC_palmitoyltrfase.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]

Gene3D

G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 6 hits.

KO

K09188.

Pfam

PF05965. FYRC. 1 hit.
PF05964. FYRN. 1 hit.
PF00628. PHD. 2 hits.
PF00856. SET. 1 hit.
[Graphical view]

SMART

SM00384. AT_hook. 2 hits.
SM00109. C1. 2 hits.
SM00542. FYRC. 1 hit.
SM00541. FYRN. 1 hit.
SM00398. HMG. 1 hit.
SM00249. PHD. 8 hits.
SM00508. PostSET. 1 hit.
SM00184. RING. 4 hits.
SM00317. SET. 1 hit.
[Graphical view]

SUPFAM

SSF57903. FYVE_PHD_ZnF. 6 hits.

PROSITE

PS51543. FYRC. 1 hit.
PS51542. FYRN. 1 hit.
PS00354. HMGI_Y. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS50216. ZF_DHHC. 1 hit.
PS01359. ZF_PHD_1. 5 hits.
PS50016. ZF_PHD_2. 6 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

65023.

SOURCE

Search...

Entry information

Entry name

MLL3_HUMAN

Accession

Primary (citable) accession number: Q8NEZ4
Secondary accession number(s): Q8NC02 , Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	January 20, 2009
Last modified:	December 14, 2011
This is version 106 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.