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Q8NEZ2

- VP37A_HUMAN

UniProt

Q8NEZ2 - VP37A_HUMAN

Protein

Vacuolar protein sorting-associated protein 37A

Gene

VPS37A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.1 Publication

    GO - Biological processi

    1. cell death Source: UniProtKB-KW
    2. endosomal transport Source: Reactome
    3. intracellular transport of virus Source: Reactome
    4. membrane organization Source: Reactome
    5. protein transport Source: UniProtKB-KW
    6. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: UniProtKB
    7. viral life cycle Source: Reactome
    8. viral process Source: Reactome
    9. viral protein processing Source: Reactome
    10. virion assembly Source: Reactome

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_115893. Membrane binding and targetting of GAG proteins.
    REACT_27258. Endosomal Sorting Complex Required For Transport (ESCRT).
    REACT_6359. Budding and maturation of HIV virion.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vacuolar protein sorting-associated protein 37A
    Short name:
    hVps37A
    Alternative name(s):
    ESCRT-I complex subunit VPS37A
    Hepatocellular carcinoma-related protein 1
    Gene namesi
    Name:VPS37A
    Synonyms:HCRP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:24928. VPS37A.

    Subcellular locationi

    GO - Cellular componenti

    1. centrosome Source: HPA
    2. cytoplasm Source: HPA
    3. endosome membrane Source: Reactome
    4. ESCRT I complex Source: UniProtKB
    5. intracellular membrane-bounded organelle Source: HPA
    6. late endosome membrane Source: UniProtKB-SubCell
    7. nucleus Source: HPA

    Keywords - Cellular componenti

    Endosome, Membrane, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Spastic paraplegia 53, autosomal recessive (SPG53) [MIM:614898]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. Complicated forms are recognized by additional variable features including spastic quadriparesis, seizures, dementia, amyotrophy, extrapyramidal disturbance, cerebral or cerebellar atrophy, optic atrophy, and peripheral neuropathy, as well as by extra neurological manifestations. SPG53 is characterized by pronounced early onset spastic paraparesis of upper and lower limbs, mild intellectual disability, kyphosis, pectus carinatum and hypertrichosis.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti382 – 3821K → N in SPG53; found in patients with complex hereditary spastic paraparesis; hypomorphic mutation; does not affect interaction with TSG101 and VPS28. 1 Publication
    VAR_068424

    Keywords - Diseasei

    Disease mutation, Hereditary spastic paraplegia, Neurodegeneration

    Organism-specific databases

    MIMi614898. phenotype.
    Orphaneti319199. Autosomal recessive spastic paraplegia type 53.
    PharmGKBiPA142670615.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 397397Vacuolar protein sorting-associated protein 37APRO_0000287198Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei18 – 181Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8NEZ2.
    PaxDbiQ8NEZ2.
    PRIDEiQ8NEZ2.

    PTM databases

    PhosphoSiteiQ8NEZ2.

    Expressioni

    Tissue specificityi

    Widely expressed. Examined tissues include heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. More abundant in liver. Strongly decreased or undetected in hepatomas.2 Publications

    Gene expression databases

    ArrayExpressiQ8NEZ2.
    BgeeiQ8NEZ2.
    CleanExiHS_VPS37A.
    GenevestigatoriQ8NEZ2.

    Organism-specific databases

    HPAiHPA024705.
    HPA024781.

    Interactioni

    Subunit structurei

    Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with TSG101, VPS28 and HGS. Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoechiometry.4 Publications

    Protein-protein interaction databases

    BioGridi126479. 12 interactions.
    IntActiQ8NEZ2. 4 interactions.
    MINTiMINT-2811404.
    STRINGi9606.ENSP00000318629.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NEZ2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini308 – 39790VPS37 C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the VPS37 family.Curated
    Contains 1 VPS37 C-terminal domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG243233.
    HOGENOMiHOG000008031.
    HOVERGENiHBG054793.
    InParanoidiQ8NEZ2.
    KOiK12185.
    OMAiPPYASQG.
    OrthoDBiEOG7KQ22B.
    PhylomeDBiQ8NEZ2.
    TreeFamiTF332146.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR009851. Mod_r.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF07200. Mod_r. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS51314. VPS37_C. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NEZ2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSWLFPLTKS ASSSAAGSPG GLTSLQQQKQ RLIESLRNSH SSIAEIQKDV    50
    EYRLPFTINN LTININILLP PQFPQEKPVI SVYPPIRHHL MDKQGVYVTS 100
    PLVNNFTMHS DLGKIIQSLL DEFWKNPPVL APTSTAFPYL YSNPSGMSPY 150
    ASQGFPFLPP YPPQEANRSI TSLSVADTVS SSTTSHTTAK PAAPSFGVLS 200
    NLPLPIPTVD ASIPTSQNGF GYKMPDVPDA FPELSELSVS QLTDMNEQEE 250
    VLLEQFLTLP QLKQIITDKD DLVKSIEELA RKNLLLEPSL EAKRQTVLDK 300
    YELLTQMKST FEKKMQRQHE LSESCSASAL QARLKVAAHE AEEESDNIAE 350
    DFLEGKMEID DFLSSFMEKR TICHCRRAKE EKLQQAIAMH SQFHAPL 397
    Length:397
    Mass (Da):44,314
    Last modified:October 1, 2002 - v1
    Checksum:i96EBB670F04A0923
    GO
    Isoform 2 (identifier: Q8NEZ2-2) [UniParc]FASTAAdd to Basket

    Also known as: beta

    The sequence of this isoform differs from the canonical sequence as follows:
         42-67: SIAEIQKDVEYRLPFTINNLTININI → R

    Show »
    Length:372
    Mass (Da):41,456
    Checksum:iC0793CE39FC71A49
    GO
    Isoform 3 (identifier: Q8NEZ2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         140-185: LYSNPSGMSP...ADTVSSSTTS → QLEIRWHHPH...KQEYHFFICC
         186-397: Missing.

    Show »
    Length:185
    Mass (Da):20,891
    Checksum:iAF11A1206F0BCA95
    GO

    Sequence cautioni

    The sequence AAH22363.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti313 – 3131K → R in BAB71381. (PubMed:14702039)Curated
    Sequence conflicti324 – 3241S → I in AAH67754. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti206 – 2061I → F.
    Corresponds to variant rs17502618 [ dbSNP | Ensembl ].
    VAR_032287
    Natural varianti213 – 2131I → V.
    Corresponds to variant rs17687375 [ dbSNP | Ensembl ].
    VAR_032288
    Natural varianti382 – 3821K → N in SPG53; found in patients with complex hereditary spastic paraparesis; hypomorphic mutation; does not affect interaction with TSG101 and VPS28. 1 Publication
    VAR_068424

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei42 – 6726SIAEI…ININI → R in isoform 2. 1 PublicationVSP_025367Add
    BLAST
    Alternative sequencei140 – 18546LYSNP…SSTTS → QLEIRWHHPHCLEISLARSS NSLGFSISSSISSTRSKQEY HFFICC in isoform 3. 1 PublicationVSP_025368Add
    BLAST
    Alternative sequencei186 – 397212Missing in isoform 3. 1 PublicationVSP_025369Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY033079 mRNA. Translation: AAK54349.1.
    AF547097 mRNA. Translation: AAQ12067.1.
    AK057204 mRNA. Translation: BAB71381.1.
    AL834189 mRNA. Translation: CAD38883.1.
    BC022363 mRNA. Translation: AAH22363.1. Different initiation.
    BC067754 mRNA. Translation: AAH67754.1.
    CCDSiCCDS47811.1. [Q8NEZ2-2]
    CCDS6001.1. [Q8NEZ2-1]
    RefSeqiNP_001138624.1. NM_001145152.1. [Q8NEZ2-2]
    NP_689628.2. NM_152415.2. [Q8NEZ2-1]
    UniGeneiHs.343873.

    Genome annotation databases

    EnsembliENST00000324849; ENSP00000318629; ENSG00000155975. [Q8NEZ2-1]
    ENST00000425020; ENSP00000412824; ENSG00000155975. [Q8NEZ2-3]
    ENST00000521829; ENSP00000429680; ENSG00000155975. [Q8NEZ2-2]
    GeneIDi137492.
    KEGGihsa:137492.
    UCSCiuc003wxj.3. human. [Q8NEZ2-1]
    uc003wxk.3. human. [Q8NEZ2-2]

    Polymorphism databases

    DMDMi74715446.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY033079 mRNA. Translation: AAK54349.1 .
    AF547097 mRNA. Translation: AAQ12067.1 .
    AK057204 mRNA. Translation: BAB71381.1 .
    AL834189 mRNA. Translation: CAD38883.1 .
    BC022363 mRNA. Translation: AAH22363.1 . Different initiation.
    BC067754 mRNA. Translation: AAH67754.1 .
    CCDSi CCDS47811.1. [Q8NEZ2-2 ]
    CCDS6001.1. [Q8NEZ2-1 ]
    RefSeqi NP_001138624.1. NM_001145152.1. [Q8NEZ2-2 ]
    NP_689628.2. NM_152415.2. [Q8NEZ2-1 ]
    UniGenei Hs.343873.

    3D structure databases

    ProteinModelPortali Q8NEZ2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126479. 12 interactions.
    IntActi Q8NEZ2. 4 interactions.
    MINTi MINT-2811404.
    STRINGi 9606.ENSP00000318629.

    PTM databases

    PhosphoSitei Q8NEZ2.

    Polymorphism databases

    DMDMi 74715446.

    Proteomic databases

    MaxQBi Q8NEZ2.
    PaxDbi Q8NEZ2.
    PRIDEi Q8NEZ2.

    Protocols and materials databases

    DNASUi 137492.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000324849 ; ENSP00000318629 ; ENSG00000155975 . [Q8NEZ2-1 ]
    ENST00000425020 ; ENSP00000412824 ; ENSG00000155975 . [Q8NEZ2-3 ]
    ENST00000521829 ; ENSP00000429680 ; ENSG00000155975 . [Q8NEZ2-2 ]
    GeneIDi 137492.
    KEGGi hsa:137492.
    UCSCi uc003wxj.3. human. [Q8NEZ2-1 ]
    uc003wxk.3. human. [Q8NEZ2-2 ]

    Organism-specific databases

    CTDi 137492.
    GeneCardsi GC08P017149.
    HGNCi HGNC:24928. VPS37A.
    HPAi HPA024705.
    HPA024781.
    MIMi 609927. gene.
    614898. phenotype.
    neXtProti NX_Q8NEZ2.
    Orphaneti 319199. Autosomal recessive spastic paraplegia type 53.
    PharmGKBi PA142670615.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG243233.
    HOGENOMi HOG000008031.
    HOVERGENi HBG054793.
    InParanoidi Q8NEZ2.
    KOi K12185.
    OMAi PPYASQG.
    OrthoDBi EOG7KQ22B.
    PhylomeDBi Q8NEZ2.
    TreeFami TF332146.

    Enzyme and pathway databases

    Reactomei REACT_115893. Membrane binding and targetting of GAG proteins.
    REACT_27258. Endosomal Sorting Complex Required For Transport (ESCRT).
    REACT_6359. Budding and maturation of HIV virion.

    Miscellaneous databases

    ChiTaRSi VPS37A. human.
    GeneWikii VPS37A.
    GenomeRNAii 137492.
    NextBioi 83653.
    PROi Q8NEZ2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NEZ2.
    Bgeei Q8NEZ2.
    CleanExi HS_VPS37A.
    Genevestigatori Q8NEZ2.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR009851. Mod_r.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF07200. Mod_r. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS51314. VPS37_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "HCRP1, a novel gene that is downregulated in hepatocellular carcinoma, encodes a growth-inhibitory protein."
      Xu Z., Liang L., Wang H., Li T., Zhao M.
      Biochem. Biophys. Res. Commun. 311:1057-1066(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Liver.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Synovium.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Melanoma.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Prostate.
    5. "The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding."
      Stuchell M.D., Garrus J.E., Mueller B., Stray K.M., Ghaffarian S., McKinnon R., Kraeusslich H.-G., Morham S.G., Sundquist W.I.
      J. Biol. Chem. 279:36059-36071(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TSG101.
    6. "The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation."
      Bache K.G., Slagsvold T., Cabezas A., Rosendal K.R., Raiborg C., Stenmark H.
      Mol. Biol. Cell 15:4337-4346(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TSG101; VPS28 AND HGS.
    7. "Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding."
      Morita E., Sandrin V., Alam S.L., Eckert D.M., Gygi S.P., Sundquist W.I.
      Cell Host Microbe 2:41-53(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TSG101, IDENTIFICATION BY MASS SPECTROMETRY.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting."
      Stefani F., Zhang L., Taylor S., Donovan J., Rollinson S., Doyotte A., Brownhill K., Bennion J., Pickering-Brown S., Woodman P.
      Curr. Biol. 21:1245-1250(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN AN ESCRT-I COMPLEX WITH UBAP1, SUBUNIT.
    12. Cited for: TISSUE SPECIFICITY, VARIANT SPG53 ASN-382, CHARACTERIZATION OF VARIANT SPG53 ASN-382.

    Entry informationi

    Entry nameiVP37A_HUMAN
    AccessioniPrimary (citable) accession number: Q8NEZ2
    Secondary accession number(s): Q336D5
    , Q6NW27, Q8N3D7, Q8TBL7, Q96DL9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3