Q8NEY3 (SPAT4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Spermatogenesis-associated protein 4

Alternative name(s):
Testis and spermatogenesis cell-related protein 2
Testis spermatocyte apoptosis-related gene 2 protein

Gene names

Name:	SPATA4
Synonyms:	TSARG2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity

Widely expressed. Ref.1

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from expression pattern Ref.1. Source: UniProtKB spermatogenesis Inferred from expression pattern Ref.1. Source: UniProtKB
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	Spermatogenesis-associated protein 4		PRO_0000072101
Natural variations
	Natural variant	149	1	Y → C. Corresponds to variant rs17062589 [ dbSNP | Ensembl ].		VAR_051369
Experimental info
	Sequence conflict	70	1	N → D in AAH21731. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8NEY3 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 7A3D1DCDC3FAC976	FASTA	305	34,751
	10 20 30 40 50 60 MAAAGQEKGY LTQTAAALDK SPSLSPQLAA PIRGRPKKCL VYPHAPKSSR LSRSVLRWLQ 70 80 90 100 110 120 GLDLSFFPRN INRDFSNGFL IAEIFCIYYP WELELSSFEN GTSLKVKLDN WAQLEKFLAR 130 140 150 160 170 180 KKFKLPKELI HGTIHCKAGV PEILIEEVYT LLTHREIKSI QDDFVNFTDY SYQMRLPLVS 190 200 210 220 230 240 RSTVSKSIKD NIRLSELLSN PNMLTNELKA EFLILLHMLQ RKLGRKLNPE WFDVKPTVGE 250 260 270 280 290 300 VTLNHLPAQA SGRRYNLKVK RGRVVPVLPN IGSGGSSHRE IHVKQAGQHS YYSAMKPIRN MDKKP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Rapid identification of human testis spermatocyte apoptosis-related gene, TSARG2, by nested PCR and draft human genome searching." Liu S.F., Li L.Y., Fu J.J., Liu G., Xing X.W., Lu G.X. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34:378-382(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY040204 mRNA. Translation: AAK72463.1. BC021731 mRNA. Translation: AAH21731.1.
IPI	IPI00329644.
RefSeq	NP_653245.2. NM_144644.2.
UniGene	Hs.481235.
3D structure databases
ProteinModelPortal	Q8NEY3.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-8201599.
STRING	9606.ENSP00000280191.
PTM databases
PhosphoSite	Q8NEY3.
Polymorphism databases
DMDM	48474486.
Proteomic databases
PaxDb	Q8NEY3.
PRIDE	Q8NEY3.
Protocols and materials databases
DNASU	132851.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000280191; ENSP00000280191; ENSG00000150628.
GeneID	132851.
KEGG	hsa:132851.
UCSC	uc003iuo.1. human.
Organism-specific databases
CTD	132851.
GeneCards	GC04M177105.
HGNC	HGNC:17333. SPATA4.
HPA	HPA019220.
MIM	609879. gene.
neXtProt	NX_Q8NEY3.
PharmGKB	PA38232.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG74411.
HOGENOM	HOG000007428.
HOVERGEN	HBG054406.
InParanoid	Q8NEY3.
OMA	FPRNINR.
OrthoDB	EOG4N5VXC.
PhylomeDB	Q8NEY3.
Gene expression databases
ArrayExpress	Q8NEY3.
Bgee	Q8NEY3.
CleanEx	HS_SPATA4.
Genevestigator	Q8NEY3.
GermOnline	ENSG00000150628. Homo sapiens.
Family and domain databases
InterPro	IPR010441. DUF1042. [Graphical view]
PANTHER	PTHR12509. PTHR12509. 1 hit.
Pfam	PF06294. DUF1042. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	132851.
NextBio	83144.
SOURCE	Search...

Entry information

Entry name

SPAT4_HUMAN

Accession

Primary (citable) accession number: Q8NEY3
Secondary accession number(s): Q8NCS5, Q8WW15

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 1, 2002
Last modified:	May 29, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.