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Protein

Spermatogenesis-associated protein 4

Gene

SPATA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 4
Alternative name(s):
Testis and spermatogenesis cell-related protein 2
Testis spermatocyte apoptosis-related gene 2 protein
Gene namesi
Name:SPATA4
Synonyms:TSARG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:17333. SPATA4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38232.

Polymorphism and mutation databases

BioMutaiSPATA4.
DMDMi48474486.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Spermatogenesis-associated protein 4PRO_0000072101Add
BLAST

Proteomic databases

PaxDbiQ8NEY3.
PRIDEiQ8NEY3.

PTM databases

PhosphoSiteiQ8NEY3.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ8NEY3.
CleanExiHS_SPATA4.
ExpressionAtlasiQ8NEY3. baseline and differential.
GenevisibleiQ8NEY3. HS.

Organism-specific databases

HPAiHPA019220.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SIAH1Q8IUQ43EBI-7067221,EBI-747107

Protein-protein interaction databases

BioGridi126337. 3 interactions.
IntActiQ8NEY3. 2 interactions.
MINTiMINT-8201599.
STRINGi9606.ENSP00000280191.

Structurei

3D structure databases

ProteinModelPortaliQ8NEY3.
SMRiQ8NEY3. Positions 58-145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IJ0V. Eukaryota.
ENOG410ZE7H. LUCA.
GeneTreeiENSGT00510000048442.
HOGENOMiHOG000007428.
HOVERGENiHBG054406.
InParanoidiQ8NEY3.
OMAiFPRNINR.
OrthoDBiEOG7FZ001.
PhylomeDBiQ8NEY3.
TreeFamiTF323506.

Family and domain databases

InterProiIPR010441. CH_2.
[Graphical view]
PANTHERiPTHR12509. PTHR12509. 1 hit.
PfamiPF06294. CH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NEY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAGQEKGY LTQTAAALDK SPSLSPQLAA PIRGRPKKCL VYPHAPKSSR
60 70 80 90 100
LSRSVLRWLQ GLDLSFFPRN INRDFSNGFL IAEIFCIYYP WELELSSFEN
110 120 130 140 150
GTSLKVKLDN WAQLEKFLAR KKFKLPKELI HGTIHCKAGV PEILIEEVYT
160 170 180 190 200
LLTHREIKSI QDDFVNFTDY SYQMRLPLVS RSTVSKSIKD NIRLSELLSN
210 220 230 240 250
PNMLTNELKA EFLILLHMLQ RKLGRKLNPE WFDVKPTVGE VTLNHLPAQA
260 270 280 290 300
SGRRYNLKVK RGRVVPVLPN IGSGGSSHRE IHVKQAGQHS YYSAMKPIRN

MDKKP
Length:305
Mass (Da):34,751
Last modified:October 1, 2002 - v1
Checksum:i7A3D1DCDC3FAC976
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701N → D in AAH21731 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti149 – 1491Y → C.
Corresponds to variant rs17062589 [ dbSNP | Ensembl ].
VAR_051369

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040204 mRNA. Translation: AAK72463.1.
BC021731 mRNA. Translation: AAH21731.1.
CCDSiCCDS3826.1.
RefSeqiNP_653245.2. NM_144644.3.
UniGeneiHs.481235.

Genome annotation databases

EnsembliENST00000280191; ENSP00000280191; ENSG00000150628.
GeneIDi132851.
KEGGihsa:132851.
UCSCiuc003iuo.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040204 mRNA. Translation: AAK72463.1.
BC021731 mRNA. Translation: AAH21731.1.
CCDSiCCDS3826.1.
RefSeqiNP_653245.2. NM_144644.3.
UniGeneiHs.481235.

3D structure databases

ProteinModelPortaliQ8NEY3.
SMRiQ8NEY3. Positions 58-145.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126337. 3 interactions.
IntActiQ8NEY3. 2 interactions.
MINTiMINT-8201599.
STRINGi9606.ENSP00000280191.

PTM databases

PhosphoSiteiQ8NEY3.

Polymorphism and mutation databases

BioMutaiSPATA4.
DMDMi48474486.

Proteomic databases

PaxDbiQ8NEY3.
PRIDEiQ8NEY3.

Protocols and materials databases

DNASUi132851.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280191; ENSP00000280191; ENSG00000150628.
GeneIDi132851.
KEGGihsa:132851.
UCSCiuc003iuo.2. human.

Organism-specific databases

CTDi132851.
GeneCardsiSPATA4.
HGNCiHGNC:17333. SPATA4.
HPAiHPA019220.
MIMi609879. gene.
neXtProtiNX_Q8NEY3.
PharmGKBiPA38232.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ0V. Eukaryota.
ENOG410ZE7H. LUCA.
GeneTreeiENSGT00510000048442.
HOGENOMiHOG000007428.
HOVERGENiHBG054406.
InParanoidiQ8NEY3.
OMAiFPRNINR.
OrthoDBiEOG7FZ001.
PhylomeDBiQ8NEY3.
TreeFamiTF323506.

Miscellaneous databases

GenomeRNAii132851.
NextBioi83144.
PROiQ8NEY3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NEY3.
CleanExiHS_SPATA4.
ExpressionAtlasiQ8NEY3. baseline and differential.
GenevisibleiQ8NEY3. HS.

Family and domain databases

InterProiIPR010441. CH_2.
[Graphical view]
PANTHERiPTHR12509. PTHR12509. 1 hit.
PfamiPF06294. CH_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Rapid identification of human testis spermatocyte apoptosis-related gene, TSARG2, by nested PCR and draft human genome searching."
    Liu S.F., Li L.Y., Fu J.J., Liu G., Xing X.W., Lu G.X.
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34:378-382(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiSPAT4_HUMAN
AccessioniPrimary (citable) accession number: Q8NEY3
Secondary accession number(s): Q8NCS5, Q8WW15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: March 16, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.