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Protein

Neuron navigator 1

Gene

NAV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in neuronal migration.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuron navigator 1
Alternative name(s):
Pore membrane and/or filament-interacting-like protein 3
Steerin-1
Unc-53 homolog 1
Short name:
unc53H1
Gene namesi
Name:NAV1
Synonyms:KIAA1151, KIAA1213, POMFIL3, STEERIN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15989. NAV1.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity

  • Note: Associates with a subset of microtubule plus ends. Enriched in neuronal growth cones (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31451.

Polymorphism and mutation databases

BioMutaiNAV1.
DMDMi147704557.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18771877Neuron navigator 1PRO_0000286974Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei90 – 901PhosphoserineCombined sources
Modified residuei142 – 1421PhosphoserineCombined sources
Modified residuei152 – 1521PhosphoserineCombined sources
Modified residuei159 – 1591PhosphothreonineCombined sources
Modified residuei194 – 1941PhosphoserineBy similarity
Modified residuei199 – 1991PhosphoserineCombined sources
Modified residuei296 – 2961PhosphoserineCombined sources
Modified residuei308 – 3081PhosphoserineCombined sources
Modified residuei312 – 3121PhosphoserineBy similarity
Modified residuei362 – 3621PhosphoserineCombined sources
Modified residuei391 – 3911PhosphoserineCombined sources
Modified residuei452 – 4521PhosphoserineCombined sources
Modified residuei474 – 4741PhosphoserineBy similarity
Modified residuei476 – 4761PhosphoserineBy similarity
Modified residuei534 – 5341PhosphothreonineCombined sources
Modified residuei572 – 5721PhosphothreonineCombined sources
Modified residuei750 – 7501PhosphoserineCombined sources
Modified residuei760 – 7601PhosphoserineCombined sources
Modified residuei808 – 8081PhosphoserineCombined sources
Modified residuei1000 – 10001PhosphoserineCombined sources
Modified residuei1006 – 10061PhosphothreonineCombined sources
Modified residuei1170 – 11701PhosphothreonineCombined sources
Modified residuei1181 – 11811PhosphoserineCombined sources
Modified residuei1265 – 12651PhosphoserineCombined sources
Modified residuei1382 – 13821PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8NEY1.
MaxQBiQ8NEY1.
PaxDbiQ8NEY1.
PRIDEiQ8NEY1.

PTM databases

iPTMnetiQ8NEY1.
PhosphoSiteiQ8NEY1.

Expressioni

Tissue specificityi

Broadly expressed at low levels. Expressed at high levels in heart, skeletal muscle and placenta.2 Publications

Developmental stagei

Expressed in fetal brain and heart.1 Publication

Gene expression databases

BgeeiQ8NEY1.
ExpressionAtlasiQ8NEY1. baseline and differential.
GenevisibleiQ8NEY1. HS.

Organism-specific databases

HPAiCAB012302.
HPA018127.
HPA027887.

Interactioni

Subunit structurei

Interacts with tubulin.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
GCC1Q96CN93EBI-10270828,EBI-746252
KRT31Q153233EBI-10270828,EBI-948001

Protein-protein interaction databases

BioGridi124605. 27 interactions.
IntActiQ8NEY1. 14 interactions.
STRINGi9606.ENSP00000356265.

Structurei

3D structure databases

ProteinModelPortaliQ8NEY1.
SMRiQ8NEY1. Positions 1539-1660.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili255 – 28026Sequence analysisAdd
BLAST
Coiled coili731 – 75626Sequence analysisAdd
BLAST
Coiled coili1072 – 116392Sequence analysisAdd
BLAST
Coiled coili1303 – 136260Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the Nav/unc-53 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEKD. Eukaryota.
ENOG410ZIQK. LUCA.
GeneTreeiENSGT00530000063334.
HOVERGENiHBG058814.
InParanoidiQ8NEY1.
KOiK16776.
OMAiSWYSEDG.
OrthoDBiEOG7GBFW1.
PhylomeDBiQ8NEY1.
TreeFamiTF329881.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NEY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLGSSVKSVQ PEVELSSGGG DEGADEPRGA GRKAAAADGR GMLPKRAKAP
60 70 80 90 100
GGGGGMAKAS AAELKVFKSG SVDSRVPGGP PASNLRKQKS LTNLSFLTDS
110 120 130 140 150
EKKLQLYEPE WSDDMAKAPK GLGKVGSKGR EAPLMSKTLS KSEHSLFQAK
160 170 180 190 200
GSPAGGAKTP LAPLAPNLGK PSRIPRGPYA EVKPLSKAPE AAVSEDGKSD
210 220 230 240 250
DELLSSKAKA QKSSGPVPSA KGQEERAFLK VDPELVVTVL GDLEQLLFSQ
260 270 280 290 300
MLDPESQRKR TVQNVLDLRQ NLEETMSSLR GSQVTHSSLE MTCYDSDDAN
310 320 330 340 350
PRSVSSLSNR SSPLSWRYGQ SSPRLQAGDA PSVGGSCRSE GTPAWYMHGE
360 370 380 390 400
RAHYSHTMPM RSPSKLSHIS RLELVESLDS DEVDLKSGYM SDSDLMGKTM
410 420 430 440 450
TEDDDITTGW DESSSISSGL SDASDNLSSE EFNASSSLNS LPSTPTASRR
460 470 480 490 500
NSTIVLRTDS EKRSLAESGL SWFSESEEKA PKKLEYDSGS LKMEPGTSKW
510 520 530 540 550
RRERPESCDD SSKGGELKKP ISLGHPGSLK KGKTPPVAVT SPITHTAQSA
560 570 580 590 600
LKVAGKPEGK ATDKGKLAVK NTGLQRSSSD AGRDRLSDAK KPPSGIARPS
610 620 630 640 650
TSGSFGYKKP PPATGTATVM QTGGSATLSK IQKSSGIPVK PVNGRKTSLD
660 670 680 690 700
VSNSAEPGFL APGARSNIQY RSLPRPAKSS SMSVTGGRGG PRPVSSSIDP
710 720 730 740 750
SLLSTKQGGL TPSRLKEPTK VASGRTTPAP VNQTDREKEK AKAKAVALDS
760 770 780 790 800
DNISLKSIGS PESTPKNQAS HPTATKLAEL PPTPLRATAK SFVKPPSLAN
810 820 830 840 850
LDKVNSNSLD LPSSSDTTHA SKVPDLHATS SASGGPLPSC FTPSPAPILN
860 870 880 890 900
INSASFSQGL ELMSGFSVPK ETRMYPKLSG LHRSMESLQM PMSLPSAFPS
910 920 930 940 950
STPVPTPPAP PAAPTEEETE ELTWSGSPRA GQLDSNQRDR NTLPKKGLRY
960 970 980 990 1000
QLQSQEETKE RRHSHTIGGL PESDDQSELP SPPALPMSLS AKGQLTNIVS
1010 1020 1030 1040 1050
PTAATTPRIT RSNSIPTHEA AFELYSGSQM GSTLSLAERP KGMIRSGSFR
1060 1070 1080 1090 1100
DPTDDVHGSV LSLASSASST YSSAEERMQS EQIRKLRREL ESSQEKVATL
1110 1120 1130 1140 1150
TSQLSANANL VAAFEQSLVN MTSRLRHLAE TAEEKDTELL DLRETIDFLK
1160 1170 1180 1190 1200
KKNSEAQAVI QGALNASETT PKELRIKRQN SSDSISSLNS ITSHSSIGSS
1210 1220 1230 1240 1250
KDADAKKKKK KSWVYELRSS FNKAFSIKKG PKSASSYSDI EEIATPDSSA
1260 1270 1280 1290 1300
PSSPKLQHGS TETASPSIKS STSSSVGTDV TEGPAHPAPH TRLFHANEEE
1310 1320 1330 1340 1350
EPEKKEVSEL RSELWEKEMK LTDIRLEALN SAHQLDQLRE TMHNMQLEVD
1360 1370 1380 1390 1400
LLKAENDRLK VAPGPSSGST PGQVPGSSAL SSPRRSLGLA LTHSFGPSLA
1410 1420 1430 1440 1450
DTDLSPMDGI STCGPKEEVT LRVVVRMPPQ HIIKGDLKQQ EFFLGCSKVS
1460 1470 1480 1490 1500
GKVDWKMLDE AVFQVFKDYI SKMDPASTLG LSTESIHGYS ISHVKRVLDA
1510 1520 1530 1540 1550
EPPEMPPCRR GVNNISVSLK GLKEKCVDSL VFETLIPKPM MQHYISLLLK
1560 1570 1580 1590 1600
HRRLVLSGPS GTGKTYLTNR LAEYLVERSG REVTEGIVST FNMHQQSCKD
1610 1620 1630 1640 1650
LQLYLSNLAN QIDRETGIGD VPLVILLDDL SEAGSISELV NGALTCKYHK
1660 1670 1680 1690 1700
CPYIIGTTNQ PVKMTPNHGL HLSFRMLTFS NNVEPANGFL VRYLRRKLVE
1710 1720 1730 1740 1750
SDSDINANKE ELLRVLDWVP KLWYHLHTFL EKHSTSDFLI GPCFFLSCPI
1760 1770 1780 1790 1800
GIEDFRTWFI DLWNNSIIPY LQEGAKDGIK VHGQKAAWED PVEWVRDTLP
1810 1820 1830 1840 1850
WPSAQQDQSK LYHLPPPTVG PHSIASPPED RTVKDSTPSS LDSDPLMAML
1860 1870
LKLQEAANYI ESPDRETILD PNLQATL
Length:1,877
Mass (Da):202,472
Last modified:May 15, 2007 - v2
Checksum:iB18C9AC9DC8D9CF2
GO
Isoform 2 (identifier: Q8NEY1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1074-1081: Missing.

Show »
Length:1,869
Mass (Da):201,511
Checksum:i34A800D1346CC5A1
GO
Isoform 3 (identifier: Q8NEY1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1214-1216: Missing.

Show »
Length:1,874
Mass (Da):202,080
Checksum:i1FC2BE3E0AA00D08
GO
Isoform 4 (identifier: Q8NEY1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     999-1055: Missing.
     1214-1216: Missing.

Show »
Length:1,817
Mass (Da):196,001
Checksum:i40D22F058C3DDFBA
GO
Isoform 5 (identifier: Q8NEY1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-389: Missing.
     390-409: MSDSDLMGKTMTEDDDITTG → MLHLPLPRSGRTVNFPRS
     1214-1216: Missing.

Show »
Length:1,483
Mass (Da):160,773
Checksum:i9346E723EDFBB5F8
GO
Isoform 6 (identifier: Q8NEY1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1074-1081: Missing.
     1173-1198: ELRIKRQNSSDSISSLNSITSHSSIG → GRTSSHRLRGNREQESKSITDFYLGP
     1199-1877: Missing.

Show »
Length:1,190
Mass (Da):126,180
Checksum:iF7942947F8623765
GO
Isoform 7 (identifier: Q8NEY1-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     999-1055: Missing.
     1074-1081: Missing.
     1214-1216: Missing.

Show »
Length:1,809
Mass (Da):195,040
Checksum:i31EDBD0679B2F653
GO

Sequence cautioni

The sequence AAH07523.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB14136.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB14142.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB14865.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAH71925.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI17010.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti267 – 2693DLR → FLW in BAA86465 (PubMed:10574461).Curated
Sequence conflicti417 – 4171S → R in AAL05591 (PubMed:12079279).Curated
Sequence conflicti508 – 5081C → R in BAB14142 (PubMed:14702039).Curated
Sequence conflicti964 – 9641S → P in BAB14142 (PubMed:14702039).Curated
Sequence conflicti1092 – 10921S → L in BAB14142 (PubMed:14702039).Curated
Sequence conflicti1109 – 11091N → S in BAB14142 (PubMed:14702039).Curated
Sequence conflicti1793 – 17931E → K in BAB14865 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti937 – 9371Q → H.
Corresponds to variant rs16849342 [ dbSNP | Ensembl ].
VAR_032245
Natural varianti1273 – 12731S → L.1 Publication
Corresponds to variant rs2820289 [ dbSNP | Ensembl ].
VAR_032246
Natural varianti1290 – 12901H → D.
Corresponds to variant rs2292822 [ dbSNP | Ensembl ].
VAR_032247
Natural varianti1527 – 15271V → I.
Corresponds to variant rs16849379 [ dbSNP | Ensembl ].
VAR_032248

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 389389Missing in isoform 5. CuratedVSP_025253Add
BLAST
Alternative sequencei390 – 40920MSDSD…DITTG → MLHLPLPRSGRTVNFPRS in isoform 5. CuratedVSP_025254Add
BLAST
Alternative sequencei999 – 105557Missing in isoform 4 and isoform 7. CuratedVSP_025255Add
BLAST
Alternative sequencei1074 – 10818Missing in isoform 2, isoform 6 and isoform 7. 2 PublicationsVSP_025256
Alternative sequencei1173 – 119826ELRIK…HSSIG → GRTSSHRLRGNREQESKSIT DFYLGP in isoform 6. 1 PublicationVSP_025257Add
BLAST
Alternative sequencei1199 – 1877679Missing in isoform 6. 1 PublicationVSP_025258Add
BLAST
Alternative sequencei1214 – 12163Missing in isoform 3, isoform 4, isoform 5 and isoform 7. 2 PublicationsVSP_025259

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043013 mRNA. Translation: AAL05591.1.
AL512788, AC092800, AL645504 Genomic DNA. Translation: CAH71925.1. Sequence problems.
AL645504, AC092800, AL512788 Genomic DNA. Translation: CAI17010.1. Sequence problems.
AL645504 Genomic DNA. Translation: CAI17011.1.
AL645504 Genomic DNA. Translation: CAI17012.1.
AL645504 Genomic DNA. Translation: CAI17013.1.
AL645504, AC092800 Genomic DNA. Translation: CAI17014.1.
AC096677 Genomic DNA. No translation available.
AJ251973 Genomic DNA. Translation: CAB66088.1.
AJ488101 mRNA. Translation: CAD32470.1.
AB032977 mRNA. Translation: BAA86465.3.
AB033039 mRNA. Translation: BAA86527.1.
AK022622 mRNA. Translation: BAB14136.1. Different initiation.
AK022631 mRNA. Translation: BAB14142.1. Different initiation.
AK024265 mRNA. Translation: BAB14865.1. Different initiation.
BC007523 mRNA. Translation: AAH07523.1. Different initiation.
CCDSiCCDS1414.2. [Q8NEY1-1]
CCDS53456.1. [Q8NEY1-5]
RefSeqiNP_001161210.1. NM_001167738.1. [Q8NEY1-5]
NP_065176.3. NM_020443.4. [Q8NEY1-1]
XP_011508399.1. XM_011510097.1. [Q8NEY1-3]
XP_011508400.1. XM_011510098.1. [Q8NEY1-2]
XP_011508404.1. XM_011510102.1. [Q8NEY1-7]
UniGeneiHs.585374.

Genome annotation databases

EnsembliENST00000367295; ENSP00000356264; ENSG00000134369. [Q8NEY1-5]
ENST00000367296; ENSP00000356265; ENSG00000134369. [Q8NEY1-1]
GeneIDi89796.
KEGGihsa:89796.
UCSCiuc001gwx.4. human. [Q8NEY1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043013 mRNA. Translation: AAL05591.1.
AL512788, AC092800, AL645504 Genomic DNA. Translation: CAH71925.1. Sequence problems.
AL645504, AC092800, AL512788 Genomic DNA. Translation: CAI17010.1. Sequence problems.
AL645504 Genomic DNA. Translation: CAI17011.1.
AL645504 Genomic DNA. Translation: CAI17012.1.
AL645504 Genomic DNA. Translation: CAI17013.1.
AL645504, AC092800 Genomic DNA. Translation: CAI17014.1.
AC096677 Genomic DNA. No translation available.
AJ251973 Genomic DNA. Translation: CAB66088.1.
AJ488101 mRNA. Translation: CAD32470.1.
AB032977 mRNA. Translation: BAA86465.3.
AB033039 mRNA. Translation: BAA86527.1.
AK022622 mRNA. Translation: BAB14136.1. Different initiation.
AK022631 mRNA. Translation: BAB14142.1. Different initiation.
AK024265 mRNA. Translation: BAB14865.1. Different initiation.
BC007523 mRNA. Translation: AAH07523.1. Different initiation.
CCDSiCCDS1414.2. [Q8NEY1-1]
CCDS53456.1. [Q8NEY1-5]
RefSeqiNP_001161210.1. NM_001167738.1. [Q8NEY1-5]
NP_065176.3. NM_020443.4. [Q8NEY1-1]
XP_011508399.1. XM_011510097.1. [Q8NEY1-3]
XP_011508400.1. XM_011510098.1. [Q8NEY1-2]
XP_011508404.1. XM_011510102.1. [Q8NEY1-7]
UniGeneiHs.585374.

3D structure databases

ProteinModelPortaliQ8NEY1.
SMRiQ8NEY1. Positions 1539-1660.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124605. 27 interactions.
IntActiQ8NEY1. 14 interactions.
STRINGi9606.ENSP00000356265.

PTM databases

iPTMnetiQ8NEY1.
PhosphoSiteiQ8NEY1.

Polymorphism and mutation databases

BioMutaiNAV1.
DMDMi147704557.

Proteomic databases

EPDiQ8NEY1.
MaxQBiQ8NEY1.
PaxDbiQ8NEY1.
PRIDEiQ8NEY1.

Protocols and materials databases

DNASUi89796.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367295; ENSP00000356264; ENSG00000134369. [Q8NEY1-5]
ENST00000367296; ENSP00000356265; ENSG00000134369. [Q8NEY1-1]
GeneIDi89796.
KEGGihsa:89796.
UCSCiuc001gwx.4. human. [Q8NEY1-1]

Organism-specific databases

CTDi89796.
GeneCardsiNAV1.
H-InvDBHIX0001462.
HGNCiHGNC:15989. NAV1.
HPAiCAB012302.
HPA018127.
HPA027887.
MIMi611628. gene.
neXtProtiNX_Q8NEY1.
PharmGKBiPA31451.
HUGEiSearch...
Search...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEKD. Eukaryota.
ENOG410ZIQK. LUCA.
GeneTreeiENSGT00530000063334.
HOVERGENiHBG058814.
InParanoidiQ8NEY1.
KOiK16776.
OMAiSWYSEDG.
OrthoDBiEOG7GBFW1.
PhylomeDBiQ8NEY1.
TreeFamiTF329881.

Miscellaneous databases

ChiTaRSiNAV1. human.
GeneWikiiNAV1.
GenomeRNAii89796.
PROiQ8NEY1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NEY1.
ExpressionAtlasiQ8NEY1. baseline and differential.
GenevisibleiQ8NEY1. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms."
    Coy J.F., Wiemann S., Bechmann I., Baechner D., Nitsch R., Kretz O., Christiansen H., Poustka A.
    Gene 290:73-94(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans."
    Maes T., Barcelo A., Buesa C.
    Genomics 80:21-30(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-1273, TISSUE SPECIFICITY.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-409, NUCLEOTIDE SEQUENCE [MRNA] OF 42-1877 (ISOFORM 1).
  5. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 108-1877 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 707-1877 (ISOFORM 6).
    Tissue: Brain.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 445-1205 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1161-1877 (ISOFORM 3).
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1122-1877 (ISOFORM 3).
    Tissue: Skin.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152; THR-159; SER-199; SER-296; SER-308; SER-391; SER-452; THR-534; THR-572; SER-760; SER-808; THR-1170; SER-1181 AND SER-1382, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-750, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90; SER-362; SER-452; SER-808; SER-1000; THR-1006 AND SER-1265, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90; SER-142 AND SER-760, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiNAV1_HUMAN
AccessioniPrimary (citable) accession number: Q8NEY1
Secondary accession number(s): A8MS88
, Q5SVH1, Q5SVH2, Q5SVH3, Q5SVH7, Q5VUY9, Q8IVL2, Q96II1, Q9H7V9, Q9H9S9, Q9H9T5, Q9UGI1, Q9ULK7, Q9ULR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: June 8, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.