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Protein

Neuron navigator 1

Gene

NAV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in neuronal migration.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuron navigator 1
Alternative name(s):
Pore membrane and/or filament-interacting-like protein 3
Steerin-1
Unc-53 homolog 1
Short name:
unc53H1
Gene namesi
Name:NAV1
Synonyms:KIAA1151, KIAA1213, POMFIL3, STEERIN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15989. NAV1.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity

  • Note: Associates with a subset of microtubule plus ends. Enriched in neuronal growth cones (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi89796.
OpenTargetsiENSG00000134369.
PharmGKBiPA31451.

Polymorphism and mutation databases

BioMutaiNAV1.
DMDMi147704557.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002869741 – 1877Neuron navigator 1Add BLAST1877

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei90PhosphoserineCombined sources1
Modified residuei142PhosphoserineCombined sources1
Modified residuei152PhosphoserineCombined sources1
Modified residuei159PhosphothreonineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei199PhosphoserineCombined sources1
Modified residuei296PhosphoserineCombined sources1
Modified residuei308PhosphoserineCombined sources1
Modified residuei312PhosphoserineCombined sources1
Modified residuei362PhosphoserineCombined sources1
Modified residuei391PhosphoserineCombined sources1
Modified residuei452PhosphoserineCombined sources1
Modified residuei474PhosphoserineCombined sources1
Modified residuei476PhosphoserineCombined sources1
Modified residuei490PhosphoserineCombined sources1
Modified residuei528PhosphoserineCombined sources1
Modified residuei534PhosphothreonineCombined sources1
Modified residuei541PhosphoserineCombined sources1
Modified residuei544PhosphothreonineCombined sources1
Modified residuei572PhosphothreonineCombined sources1
Modified residuei648PhosphoserineCombined sources1
Modified residuei688Omega-N-methylarginineBy similarity1
Modified residuei750PhosphoserineCombined sources1
Modified residuei754PhosphoserineCombined sources1
Modified residuei760PhosphoserineCombined sources1
Modified residuei797PhosphoserineCombined sources1
Modified residuei808PhosphoserineCombined sources1
Modified residuei1000PhosphoserineCombined sources1
Modified residuei1006PhosphothreonineCombined sources1
Modified residuei1170PhosphothreonineCombined sources1
Modified residuei1181PhosphoserineCombined sources1
Modified residuei1265PhosphoserineCombined sources1
Modified residuei1382PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ8NEY1.
MaxQBiQ8NEY1.
PaxDbiQ8NEY1.
PeptideAtlasiQ8NEY1.
PRIDEiQ8NEY1.

PTM databases

iPTMnetiQ8NEY1.
PhosphoSitePlusiQ8NEY1.

Expressioni

Tissue specificityi

Broadly expressed at low levels. Expressed at high levels in heart, skeletal muscle and placenta.2 Publications

Developmental stagei

Expressed in fetal brain and heart.1 Publication

Gene expression databases

BgeeiENSG00000134369.
ExpressionAtlasiQ8NEY1. baseline and differential.
GenevisibleiQ8NEY1. HS.

Organism-specific databases

HPAiCAB012302.
HPA018127.
HPA027887.

Interactioni

Subunit structurei

Interacts with tubulin.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
GCC1Q96CN93EBI-10270828,EBI-746252
KRT31Q153233EBI-10270828,EBI-948001

Protein-protein interaction databases

BioGridi124605. 27 interactors.
IntActiQ8NEY1. 17 interactors.
STRINGi9606.ENSP00000356265.

Structurei

3D structure databases

ProteinModelPortaliQ8NEY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili255 – 280Sequence analysisAdd BLAST26
Coiled coili731 – 756Sequence analysisAdd BLAST26
Coiled coili1072 – 1163Sequence analysisAdd BLAST92
Coiled coili1303 – 1362Sequence analysisAdd BLAST60

Sequence similaritiesi

Belongs to the Nav/unc-53 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEKD. Eukaryota.
ENOG410ZIQK. LUCA.
GeneTreeiENSGT00530000063334.
HOVERGENiHBG058814.
InParanoidiQ8NEY1.
KOiK16776.
OMAiVNGRMDW.
OrthoDBiEOG091G03NO.
PhylomeDBiQ8NEY1.
TreeFamiTF329881.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NEY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLGSSVKSVQ PEVELSSGGG DEGADEPRGA GRKAAAADGR GMLPKRAKAP
60 70 80 90 100
GGGGGMAKAS AAELKVFKSG SVDSRVPGGP PASNLRKQKS LTNLSFLTDS
110 120 130 140 150
EKKLQLYEPE WSDDMAKAPK GLGKVGSKGR EAPLMSKTLS KSEHSLFQAK
160 170 180 190 200
GSPAGGAKTP LAPLAPNLGK PSRIPRGPYA EVKPLSKAPE AAVSEDGKSD
210 220 230 240 250
DELLSSKAKA QKSSGPVPSA KGQEERAFLK VDPELVVTVL GDLEQLLFSQ
260 270 280 290 300
MLDPESQRKR TVQNVLDLRQ NLEETMSSLR GSQVTHSSLE MTCYDSDDAN
310 320 330 340 350
PRSVSSLSNR SSPLSWRYGQ SSPRLQAGDA PSVGGSCRSE GTPAWYMHGE
360 370 380 390 400
RAHYSHTMPM RSPSKLSHIS RLELVESLDS DEVDLKSGYM SDSDLMGKTM
410 420 430 440 450
TEDDDITTGW DESSSISSGL SDASDNLSSE EFNASSSLNS LPSTPTASRR
460 470 480 490 500
NSTIVLRTDS EKRSLAESGL SWFSESEEKA PKKLEYDSGS LKMEPGTSKW
510 520 530 540 550
RRERPESCDD SSKGGELKKP ISLGHPGSLK KGKTPPVAVT SPITHTAQSA
560 570 580 590 600
LKVAGKPEGK ATDKGKLAVK NTGLQRSSSD AGRDRLSDAK KPPSGIARPS
610 620 630 640 650
TSGSFGYKKP PPATGTATVM QTGGSATLSK IQKSSGIPVK PVNGRKTSLD
660 670 680 690 700
VSNSAEPGFL APGARSNIQY RSLPRPAKSS SMSVTGGRGG PRPVSSSIDP
710 720 730 740 750
SLLSTKQGGL TPSRLKEPTK VASGRTTPAP VNQTDREKEK AKAKAVALDS
760 770 780 790 800
DNISLKSIGS PESTPKNQAS HPTATKLAEL PPTPLRATAK SFVKPPSLAN
810 820 830 840 850
LDKVNSNSLD LPSSSDTTHA SKVPDLHATS SASGGPLPSC FTPSPAPILN
860 870 880 890 900
INSASFSQGL ELMSGFSVPK ETRMYPKLSG LHRSMESLQM PMSLPSAFPS
910 920 930 940 950
STPVPTPPAP PAAPTEEETE ELTWSGSPRA GQLDSNQRDR NTLPKKGLRY
960 970 980 990 1000
QLQSQEETKE RRHSHTIGGL PESDDQSELP SPPALPMSLS AKGQLTNIVS
1010 1020 1030 1040 1050
PTAATTPRIT RSNSIPTHEA AFELYSGSQM GSTLSLAERP KGMIRSGSFR
1060 1070 1080 1090 1100
DPTDDVHGSV LSLASSASST YSSAEERMQS EQIRKLRREL ESSQEKVATL
1110 1120 1130 1140 1150
TSQLSANANL VAAFEQSLVN MTSRLRHLAE TAEEKDTELL DLRETIDFLK
1160 1170 1180 1190 1200
KKNSEAQAVI QGALNASETT PKELRIKRQN SSDSISSLNS ITSHSSIGSS
1210 1220 1230 1240 1250
KDADAKKKKK KSWVYELRSS FNKAFSIKKG PKSASSYSDI EEIATPDSSA
1260 1270 1280 1290 1300
PSSPKLQHGS TETASPSIKS STSSSVGTDV TEGPAHPAPH TRLFHANEEE
1310 1320 1330 1340 1350
EPEKKEVSEL RSELWEKEMK LTDIRLEALN SAHQLDQLRE TMHNMQLEVD
1360 1370 1380 1390 1400
LLKAENDRLK VAPGPSSGST PGQVPGSSAL SSPRRSLGLA LTHSFGPSLA
1410 1420 1430 1440 1450
DTDLSPMDGI STCGPKEEVT LRVVVRMPPQ HIIKGDLKQQ EFFLGCSKVS
1460 1470 1480 1490 1500
GKVDWKMLDE AVFQVFKDYI SKMDPASTLG LSTESIHGYS ISHVKRVLDA
1510 1520 1530 1540 1550
EPPEMPPCRR GVNNISVSLK GLKEKCVDSL VFETLIPKPM MQHYISLLLK
1560 1570 1580 1590 1600
HRRLVLSGPS GTGKTYLTNR LAEYLVERSG REVTEGIVST FNMHQQSCKD
1610 1620 1630 1640 1650
LQLYLSNLAN QIDRETGIGD VPLVILLDDL SEAGSISELV NGALTCKYHK
1660 1670 1680 1690 1700
CPYIIGTTNQ PVKMTPNHGL HLSFRMLTFS NNVEPANGFL VRYLRRKLVE
1710 1720 1730 1740 1750
SDSDINANKE ELLRVLDWVP KLWYHLHTFL EKHSTSDFLI GPCFFLSCPI
1760 1770 1780 1790 1800
GIEDFRTWFI DLWNNSIIPY LQEGAKDGIK VHGQKAAWED PVEWVRDTLP
1810 1820 1830 1840 1850
WPSAQQDQSK LYHLPPPTVG PHSIASPPED RTVKDSTPSS LDSDPLMAML
1860 1870
LKLQEAANYI ESPDRETILD PNLQATL
Length:1,877
Mass (Da):202,472
Last modified:May 15, 2007 - v2
Checksum:iB18C9AC9DC8D9CF2
GO
Isoform 2 (identifier: Q8NEY1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1074-1081: Missing.

Show »
Length:1,869
Mass (Da):201,511
Checksum:i34A800D1346CC5A1
GO
Isoform 3 (identifier: Q8NEY1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1214-1216: Missing.

Show »
Length:1,874
Mass (Da):202,080
Checksum:i1FC2BE3E0AA00D08
GO
Isoform 4 (identifier: Q8NEY1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     999-1055: Missing.
     1214-1216: Missing.

Show »
Length:1,817
Mass (Da):196,001
Checksum:i40D22F058C3DDFBA
GO
Isoform 5 (identifier: Q8NEY1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-389: Missing.
     390-409: MSDSDLMGKTMTEDDDITTG → MLHLPLPRSGRTVNFPRS
     1214-1216: Missing.

Show »
Length:1,483
Mass (Da):160,773
Checksum:i9346E723EDFBB5F8
GO
Isoform 6 (identifier: Q8NEY1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1074-1081: Missing.
     1173-1198: ELRIKRQNSSDSISSLNSITSHSSIG → GRTSSHRLRGNREQESKSITDFYLGP
     1199-1877: Missing.

Show »
Length:1,190
Mass (Da):126,180
Checksum:iF7942947F8623765
GO
Isoform 7 (identifier: Q8NEY1-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     999-1055: Missing.
     1074-1081: Missing.
     1214-1216: Missing.

Show »
Length:1,809
Mass (Da):195,040
Checksum:i31EDBD0679B2F653
GO

Sequence cautioni

The sequence AAH07523 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14136 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14142 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14865 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAH71925 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI17010 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti267 – 269DLR → FLW in BAA86465 (PubMed:10574461).Curated3
Sequence conflicti417S → R in AAL05591 (PubMed:12079279).Curated1
Sequence conflicti508C → R in BAB14142 (PubMed:14702039).Curated1
Sequence conflicti964S → P in BAB14142 (PubMed:14702039).Curated1
Sequence conflicti1092S → L in BAB14142 (PubMed:14702039).Curated1
Sequence conflicti1109N → S in BAB14142 (PubMed:14702039).Curated1
Sequence conflicti1793E → K in BAB14865 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032245937Q → H.Corresponds to variant rs16849342dbSNPEnsembl.1
Natural variantiVAR_0322461273S → L.1 PublicationCorresponds to variant rs2820289dbSNPEnsembl.1
Natural variantiVAR_0322471290H → D.Corresponds to variant rs2292822dbSNPEnsembl.1
Natural variantiVAR_0322481527V → I.Corresponds to variant rs16849379dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0252531 – 389Missing in isoform 5. CuratedAdd BLAST389
Alternative sequenceiVSP_025254390 – 409MSDSD…DITTG → MLHLPLPRSGRTVNFPRS in isoform 5. CuratedAdd BLAST20
Alternative sequenceiVSP_025255999 – 1055Missing in isoform 4 and isoform 7. CuratedAdd BLAST57
Alternative sequenceiVSP_0252561074 – 1081Missing in isoform 2, isoform 6 and isoform 7. 2 Publications8
Alternative sequenceiVSP_0252571173 – 1198ELRIK…HSSIG → GRTSSHRLRGNREQESKSIT DFYLGP in isoform 6. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_0252581199 – 1877Missing in isoform 6. 1 PublicationAdd BLAST679
Alternative sequenceiVSP_0252591214 – 1216Missing in isoform 3, isoform 4, isoform 5 and isoform 7. 2 Publications3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043013 mRNA. Translation: AAL05591.1.
AL512788, AC092800, AL645504 Genomic DNA. Translation: CAH71925.1. Sequence problems.
AL645504, AC092800, AL512788 Genomic DNA. Translation: CAI17010.1. Sequence problems.
AL645504 Genomic DNA. Translation: CAI17011.1.
AL645504 Genomic DNA. Translation: CAI17012.1.
AL645504 Genomic DNA. Translation: CAI17013.1.
AL645504, AC092800 Genomic DNA. Translation: CAI17014.1.
AC096677 Genomic DNA. No translation available.
AJ251973 Genomic DNA. Translation: CAB66088.1.
AJ488101 mRNA. Translation: CAD32470.1.
AB032977 mRNA. Translation: BAA86465.3.
AB033039 mRNA. Translation: BAA86527.1.
AK022622 mRNA. Translation: BAB14136.1. Different initiation.
AK022631 mRNA. Translation: BAB14142.1. Different initiation.
AK024265 mRNA. Translation: BAB14865.1. Different initiation.
BC007523 mRNA. Translation: AAH07523.1. Different initiation.
CCDSiCCDS1414.2. [Q8NEY1-1]
CCDS53456.1. [Q8NEY1-5]
RefSeqiNP_001161210.1. NM_001167738.1. [Q8NEY1-5]
NP_065176.3. NM_020443.4. [Q8NEY1-1]
XP_011508399.1. XM_011510097.1. [Q8NEY1-3]
XP_011508400.1. XM_011510098.1. [Q8NEY1-2]
XP_011508404.1. XM_011510102.1. [Q8NEY1-7]
XP_016858240.1. XM_017002751.1. [Q8NEY1-4]
UniGeneiHs.585374.

Genome annotation databases

EnsembliENST00000367295; ENSP00000356264; ENSG00000134369. [Q8NEY1-5]
ENST00000367296; ENSP00000356265; ENSG00000134369. [Q8NEY1-1]
GeneIDi89796.
KEGGihsa:89796.
UCSCiuc001gwx.4. human. [Q8NEY1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY043013 mRNA. Translation: AAL05591.1.
AL512788, AC092800, AL645504 Genomic DNA. Translation: CAH71925.1. Sequence problems.
AL645504, AC092800, AL512788 Genomic DNA. Translation: CAI17010.1. Sequence problems.
AL645504 Genomic DNA. Translation: CAI17011.1.
AL645504 Genomic DNA. Translation: CAI17012.1.
AL645504 Genomic DNA. Translation: CAI17013.1.
AL645504, AC092800 Genomic DNA. Translation: CAI17014.1.
AC096677 Genomic DNA. No translation available.
AJ251973 Genomic DNA. Translation: CAB66088.1.
AJ488101 mRNA. Translation: CAD32470.1.
AB032977 mRNA. Translation: BAA86465.3.
AB033039 mRNA. Translation: BAA86527.1.
AK022622 mRNA. Translation: BAB14136.1. Different initiation.
AK022631 mRNA. Translation: BAB14142.1. Different initiation.
AK024265 mRNA. Translation: BAB14865.1. Different initiation.
BC007523 mRNA. Translation: AAH07523.1. Different initiation.
CCDSiCCDS1414.2. [Q8NEY1-1]
CCDS53456.1. [Q8NEY1-5]
RefSeqiNP_001161210.1. NM_001167738.1. [Q8NEY1-5]
NP_065176.3. NM_020443.4. [Q8NEY1-1]
XP_011508399.1. XM_011510097.1. [Q8NEY1-3]
XP_011508400.1. XM_011510098.1. [Q8NEY1-2]
XP_011508404.1. XM_011510102.1. [Q8NEY1-7]
XP_016858240.1. XM_017002751.1. [Q8NEY1-4]
UniGeneiHs.585374.

3D structure databases

ProteinModelPortaliQ8NEY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124605. 27 interactors.
IntActiQ8NEY1. 17 interactors.
STRINGi9606.ENSP00000356265.

PTM databases

iPTMnetiQ8NEY1.
PhosphoSitePlusiQ8NEY1.

Polymorphism and mutation databases

BioMutaiNAV1.
DMDMi147704557.

Proteomic databases

EPDiQ8NEY1.
MaxQBiQ8NEY1.
PaxDbiQ8NEY1.
PeptideAtlasiQ8NEY1.
PRIDEiQ8NEY1.

Protocols and materials databases

DNASUi89796.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367295; ENSP00000356264; ENSG00000134369. [Q8NEY1-5]
ENST00000367296; ENSP00000356265; ENSG00000134369. [Q8NEY1-1]
GeneIDi89796.
KEGGihsa:89796.
UCSCiuc001gwx.4. human. [Q8NEY1-1]

Organism-specific databases

CTDi89796.
DisGeNETi89796.
GeneCardsiNAV1.
H-InvDBHIX0001462.
HGNCiHGNC:15989. NAV1.
HPAiCAB012302.
HPA018127.
HPA027887.
MIMi611628. gene.
neXtProtiNX_Q8NEY1.
OpenTargetsiENSG00000134369.
PharmGKBiPA31451.
HUGEiSearch...
Search...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEKD. Eukaryota.
ENOG410ZIQK. LUCA.
GeneTreeiENSGT00530000063334.
HOVERGENiHBG058814.
InParanoidiQ8NEY1.
KOiK16776.
OMAiVNGRMDW.
OrthoDBiEOG091G03NO.
PhylomeDBiQ8NEY1.
TreeFamiTF329881.

Miscellaneous databases

ChiTaRSiNAV1. human.
GeneWikiiNAV1.
GenomeRNAii89796.
PROiQ8NEY1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134369.
ExpressionAtlasiQ8NEY1. baseline and differential.
GenevisibleiQ8NEY1. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNAV1_HUMAN
AccessioniPrimary (citable) accession number: Q8NEY1
Secondary accession number(s): A8MS88
, Q5SVH1, Q5SVH2, Q5SVH3, Q5SVH7, Q5VUY9, Q8IVL2, Q96II1, Q9H7V9, Q9H9S9, Q9H9T5, Q9UGI1, Q9ULK7, Q9ULR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 30, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.