Q8NEY1 (NAV1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuron navigator 1

Alternative name(s):
Pore membrane and/or filament-interacting-like protein 3
Steerin-1
Unc-53 homolog 1
Short name=unc53H1

Gene names

Name:	NAV1
Synonyms:	KIAA1151, KIAA1213, POMFIL3, STEERIN1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1877 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in neuronal migration By similarity.
Subunit structure	Interacts with tubulin By similarity.
Subcellular location	Cytoplasm › cytoskeleton By similarity. Note: Associates with a subset of microtubule plus ends. Enriched in neuronal growth cones By similarity.
Tissue specificity	Broadly expressed at low levels. Expressed at high levels in heart, skeletal muscle and placenta. Ref.1 Ref.2
Developmental stage	Expressed in fetal brain and heart. Ref.1
Sequence similarities	Belongs to the Nav/unc-53 family.
Sequence caution	The sequence AAH07523.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB14136.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB14142.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB14865.1 differs from that shown. Reason: Erroneous initiation. The sequence CAH71925.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI17010.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Cytoplasm Cytoskeleton Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NEY1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NEY1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1074-1081: Missing.

Isoform 3 (identifier: Q8NEY1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1214-1216: Missing.

Isoform 4 (identifier: Q8NEY1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     999-1055: Missing.
     1214-1216: Missing.

Isoform 5 (identifier: Q8NEY1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-389: Missing.
     390-409: MSDSDLMGKTMTEDDDITTG → MLHLPLPRSGRTVNFPRS
     1214-1216: Missing.

Isoform 6 (identifier: Q8NEY1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1074-1081: Missing.
     1173-1198: ELRIKRQNSSDSISSLNSITSHSSIG → GRTSSHRLRGNREQESKSITDFYLGP
     1199-1877: Missing.

Isoform 7 (identifier: Q8NEY1-7)

The sequence of this isoform differs from the canonical sequence as follows:
     999-1055: Missing.
     1074-1081: Missing.
     1214-1216: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1877	1877	Neuron navigator 1		PRO_0000286974
Regions
	Coiled coil	255 – 280	26	Potential
	Coiled coil	731 – 756	26	Potential
	Coiled coil	1072 – 1163	92	Potential
	Coiled coil	1303 – 1362	60	Potential
Amino acid modifications
	Modified residue	142	1	Phosphoserine By similarity
	Modified residue	152	1	Phosphoserine Ref.9
	Modified residue	159	1	Phosphothreonine Ref.9
	Modified residue	199	1	Phosphoserine Ref.9
	Modified residue	296	1	Phosphoserine Ref.9
	Modified residue	308	1	Phosphoserine Ref.9
	Modified residue	311	1	Phosphoserine Ref.9
	Modified residue	391	1	Phosphoserine Ref.9 Ref.10
	Modified residue	452	1	Phosphoserine Ref.9
	Modified residue	534	1	Phosphothreonine Ref.9
	Modified residue	541	1	Phosphoserine Ref.9
	Modified residue	572	1	Phosphothreonine Ref.9
	Modified residue	726	1	Phosphothreonine Ref.8
	Modified residue	750	1	Phosphoserine Ref.11
	Modified residue	760	1	Phosphoserine Ref.9 Ref.10
	Modified residue	808	1	Phosphoserine Ref.9
	Modified residue	1000	1	Phosphoserine Ref.10
	Modified residue	1002	1	Phosphothreonine Ref.10
	Modified residue	1170	1	Phosphothreonine Ref.9
	Modified residue	1181	1	Phosphoserine Ref.9
	Modified residue	1253	1	Phosphoserine Ref.10
	Modified residue	1382	1	Phosphoserine Ref.9 Ref.10
Natural variations
	Alternative sequence	1 – 389	389	Missing in isoform 5.		VSP_025253
	Alternative sequence	390 – 409	20	MSDSD…DITTG → MLHLPLPRSGRTVNFPRS in isoform 5.		VSP_025254
	Alternative sequence	999 – 1055	57	Missing in isoform 4 and isoform 7.		VSP_025255
	Alternative sequence	1074 – 1081	8	Missing in isoform 2, isoform 6 and isoform 7.		VSP_025256
	Alternative sequence	1173 – 1198	26	ELRIK…HSSIG → GRTSSHRLRGNREQESKSIT DFYLGP in isoform 6.		VSP_025257
	Alternative sequence	1199 – 1877	679	Missing in isoform 6.		VSP_025258
	Alternative sequence	1214 – 1216	3	Missing in isoform 3, isoform 4, isoform 5 and isoform 7.		VSP_025259
	Natural variant	937	1	Q → H. Corresponds to variant rs16849342 [ dbSNP | Ensembl ].		VAR_032245
	Natural variant	1273	1	S → L. Ref.2 Corresponds to variant rs2820289 [ dbSNP | Ensembl ].		VAR_032246
	Natural variant	1290	1	H → D. Corresponds to variant rs2292822 [ dbSNP | Ensembl ].		VAR_032247
	Natural variant	1527	1	V → I. Corresponds to variant rs16849379 [ dbSNP | Ensembl ].		VAR_032248
Experimental info
	Sequence conflict	267 – 269	3	DLR → FLW in BAA86465. Ref.5
	Sequence conflict	417	1	S → R in AAL05591. Ref.2
	Sequence conflict	508	1	C → R in BAB14142. Ref.6
	Sequence conflict	964	1	S → P in BAB14142. Ref.6
	Sequence conflict	1092	1	S → L in BAB14142. Ref.6
	Sequence conflict	1109	1	N → S in BAB14142. Ref.6
	Sequence conflict	1793	1	E → K in BAB14865. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 15, 2007. Version 2. Checksum: B18C9AC9DC8D9CF2	FASTA	1,877	202,472
	10 20 30 40 50 60 MLGSSVKSVQ PEVELSSGGG DEGADEPRGA GRKAAAADGR GMLPKRAKAP GGGGGMAKAS 70 80 90 100 110 120 AAELKVFKSG SVDSRVPGGP PASNLRKQKS LTNLSFLTDS EKKLQLYEPE WSDDMAKAPK 130 140 150 160 170 180 GLGKVGSKGR EAPLMSKTLS KSEHSLFQAK GSPAGGAKTP LAPLAPNLGK PSRIPRGPYA 190 200 210 220 230 240 EVKPLSKAPE AAVSEDGKSD DELLSSKAKA QKSSGPVPSA KGQEERAFLK VDPELVVTVL 250 260 270 280 290 300 GDLEQLLFSQ MLDPESQRKR TVQNVLDLRQ NLEETMSSLR GSQVTHSSLE MTCYDSDDAN 310 320 330 340 350 360 PRSVSSLSNR SSPLSWRYGQ SSPRLQAGDA PSVGGSCRSE GTPAWYMHGE RAHYSHTMPM 370 380 390 400 410 420 RSPSKLSHIS RLELVESLDS DEVDLKSGYM SDSDLMGKTM TEDDDITTGW DESSSISSGL 430 440 450 460 470 480 SDASDNLSSE EFNASSSLNS LPSTPTASRR NSTIVLRTDS EKRSLAESGL SWFSESEEKA 490 500 510 520 530 540 PKKLEYDSGS LKMEPGTSKW RRERPESCDD SSKGGELKKP ISLGHPGSLK KGKTPPVAVT 550 560 570 580 590 600 SPITHTAQSA LKVAGKPEGK ATDKGKLAVK NTGLQRSSSD AGRDRLSDAK KPPSGIARPS 610 620 630 640 650 660 TSGSFGYKKP PPATGTATVM QTGGSATLSK IQKSSGIPVK PVNGRKTSLD VSNSAEPGFL 670 680 690 700 710 720 APGARSNIQY RSLPRPAKSS SMSVTGGRGG PRPVSSSIDP SLLSTKQGGL TPSRLKEPTK 730 740 750 760 770 780 VASGRTTPAP VNQTDREKEK AKAKAVALDS DNISLKSIGS PESTPKNQAS HPTATKLAEL 790 800 810 820 830 840 PPTPLRATAK SFVKPPSLAN LDKVNSNSLD LPSSSDTTHA SKVPDLHATS SASGGPLPSC 850 860 870 880 890 900 FTPSPAPILN INSASFSQGL ELMSGFSVPK ETRMYPKLSG LHRSMESLQM PMSLPSAFPS 910 920 930 940 950 960 STPVPTPPAP PAAPTEEETE ELTWSGSPRA GQLDSNQRDR NTLPKKGLRY QLQSQEETKE 970 980 990 1000 1010 1020 RRHSHTIGGL PESDDQSELP SPPALPMSLS AKGQLTNIVS PTAATTPRIT RSNSIPTHEA 1030 1040 1050 1060 1070 1080 AFELYSGSQM GSTLSLAERP KGMIRSGSFR DPTDDVHGSV LSLASSASST YSSAEERMQS 1090 1100 1110 1120 1130 1140 EQIRKLRREL ESSQEKVATL TSQLSANANL VAAFEQSLVN MTSRLRHLAE TAEEKDTELL 1150 1160 1170 1180 1190 1200 DLRETIDFLK KKNSEAQAVI QGALNASETT PKELRIKRQN SSDSISSLNS ITSHSSIGSS 1210 1220 1230 1240 1250 1260 KDADAKKKKK KSWVYELRSS FNKAFSIKKG PKSASSYSDI EEIATPDSSA PSSPKLQHGS 1270 1280 1290 1300 1310 1320 TETASPSIKS STSSSVGTDV TEGPAHPAPH TRLFHANEEE EPEKKEVSEL RSELWEKEMK 1330 1340 1350 1360 1370 1380 LTDIRLEALN SAHQLDQLRE TMHNMQLEVD LLKAENDRLK VAPGPSSGST PGQVPGSSAL 1390 1400 1410 1420 1430 1440 SSPRRSLGLA LTHSFGPSLA DTDLSPMDGI STCGPKEEVT LRVVVRMPPQ HIIKGDLKQQ 1450 1460 1470 1480 1490 1500 EFFLGCSKVS GKVDWKMLDE AVFQVFKDYI SKMDPASTLG LSTESIHGYS ISHVKRVLDA 1510 1520 1530 1540 1550 1560 EPPEMPPCRR GVNNISVSLK GLKEKCVDSL VFETLIPKPM MQHYISLLLK HRRLVLSGPS 1570 1580 1590 1600 1610 1620 GTGKTYLTNR LAEYLVERSG REVTEGIVST FNMHQQSCKD LQLYLSNLAN QIDRETGIGD 1630 1640 1650 1660 1670 1680 VPLVILLDDL SEAGSISELV NGALTCKYHK CPYIIGTTNQ PVKMTPNHGL HLSFRMLTFS 1690 1700 1710 1720 1730 1740 NNVEPANGFL VRYLRRKLVE SDSDINANKE ELLRVLDWVP KLWYHLHTFL EKHSTSDFLI 1750 1760 1770 1780 1790 1800 GPCFFLSCPI GIEDFRTWFI DLWNNSIIPY LQEGAKDGIK VHGQKAAWED PVEWVRDTLP 1810 1820 1830 1840 1850 1860 WPSAQQDQSK LYHLPPPTVG PHSIASPPED RTVKDSTPSS LDSDPLMAML LKLQEAANYI 1870 ESPDRETILD PNLQATL
	Isoform 2 [UniParc]. Checksum: 34A800D1346CC5A1	FASTA	1,869	201,511
	10 20 30 40 50 60 MLGSSVKSVQ PEVELSSGGG DEGADEPRGA GRKAAAADGR GMLPKRAKAP GGGGGMAKAS 70 80 90 100 110 120 AAELKVFKSG SVDSRVPGGP PASNLRKQKS LTNLSFLTDS EKKLQLYEPE WSDDMAKAPK 130 140 150 160 170 180 GLGKVGSKGR EAPLMSKTLS KSEHSLFQAK GSPAGGAKTP LAPLAPNLGK PSRIPRGPYA 190 200 210 220 230 240 EVKPLSKAPE AAVSEDGKSD DELLSSKAKA QKSSGPVPSA KGQEERAFLK VDPELVVTVL 250 260 270 280 290 300 GDLEQLLFSQ MLDPESQRKR TVQNVLDLRQ NLEETMSSLR GSQVTHSSLE MTCYDSDDAN 310 320 330 340 350 360 PRSVSSLSNR SSPLSWRYGQ SSPRLQAGDA PSVGGSCRSE GTPAWYMHGE RAHYSHTMPM 370 380 390 400 410 420 RSPSKLSHIS RLELVESLDS DEVDLKSGYM SDSDLMGKTM TEDDDITTGW DESSSISSGL 430 440 450 460 470 480 SDASDNLSSE EFNASSSLNS LPSTPTASRR NSTIVLRTDS EKRSLAESGL SWFSESEEKA 490 500 510 520 530 540 PKKLEYDSGS LKMEPGTSKW RRERPESCDD SSKGGELKKP ISLGHPGSLK KGKTPPVAVT 550 560 570 580 590 600 SPITHTAQSA LKVAGKPEGK ATDKGKLAVK NTGLQRSSSD AGRDRLSDAK KPPSGIARPS 610 620 630 640 650 660 TSGSFGYKKP PPATGTATVM QTGGSATLSK IQKSSGIPVK PVNGRKTSLD VSNSAEPGFL 670 680 690 700 710 720 APGARSNIQY RSLPRPAKSS SMSVTGGRGG PRPVSSSIDP SLLSTKQGGL TPSRLKEPTK 730 740 750 760 770 780 VASGRTTPAP VNQTDREKEK AKAKAVALDS DNISLKSIGS PESTPKNQAS HPTATKLAEL 790 800 810 820 830 840 PPTPLRATAK SFVKPPSLAN LDKVNSNSLD LPSSSDTTHA SKVPDLHATS SASGGPLPSC 850 860 870 880 890 900 FTPSPAPILN INSASFSQGL ELMSGFSVPK ETRMYPKLSG LHRSMESLQM PMSLPSAFPS 910 920 930 940 950 960 STPVPTPPAP PAAPTEEETE ELTWSGSPRA GQLDSNQRDR NTLPKKGLRY QLQSQEETKE 970 980 990 1000 1010 1020 RRHSHTIGGL PESDDQSELP SPPALPMSLS AKGQLTNIVS PTAATTPRIT RSNSIPTHEA 1030 1040 1050 1060 1070 1080 AFELYSGSQM GSTLSLAERP KGMIRSGSFR DPTDDVHGSV LSLASSASST YSSQIRKLRR 1090 1100 1110 1120 1130 1140 ELESSQEKVA TLTSQLSANA NLVAAFEQSL VNMTSRLRHL AETAEEKDTE LLDLRETIDF 1150 1160 1170 1180 1190 1200 LKKKNSEAQA VIQGALNASE TTPKELRIKR QNSSDSISSL NSITSHSSIG SSKDADAKKK 1210 1220 1230 1240 1250 1260 KKKSWVYELR SSFNKAFSIK KGPKSASSYS DIEEIATPDS SAPSSPKLQH GSTETASPSI 1270 1280 1290 1300 1310 1320 KSSTSSSVGT DVTEGPAHPA PHTRLFHANE EEEPEKKEVS ELRSELWEKE MKLTDIRLEA 1330 1340 1350 1360 1370 1380 LNSAHQLDQL RETMHNMQLE VDLLKAENDR LKVAPGPSSG STPGQVPGSS ALSSPRRSLG 1390 1400 1410 1420 1430 1440 LALTHSFGPS LADTDLSPMD GISTCGPKEE VTLRVVVRMP PQHIIKGDLK QQEFFLGCSK 1450 1460 1470 1480 1490 1500 VSGKVDWKML DEAVFQVFKD YISKMDPAST LGLSTESIHG YSISHVKRVL DAEPPEMPPC 1510 1520 1530 1540 1550 1560 RRGVNNISVS LKGLKEKCVD SLVFETLIPK PMMQHYISLL LKHRRLVLSG PSGTGKTYLT 1570 1580 1590 1600 1610 1620 NRLAEYLVER SGREVTEGIV STFNMHQQSC KDLQLYLSNL ANQIDRETGI GDVPLVILLD 1630 1640 1650 1660 1670 1680 DLSEAGSISE LVNGALTCKY HKCPYIIGTT NQPVKMTPNH GLHLSFRMLT FSNNVEPANG 1690 1700 1710 1720 1730 1740 FLVRYLRRKL VESDSDINAN KEELLRVLDW VPKLWYHLHT FLEKHSTSDF LIGPCFFLSC 1750 1760 1770 1780 1790 1800 PIGIEDFRTW FIDLWNNSII PYLQEGAKDG IKVHGQKAAW EDPVEWVRDT LPWPSAQQDQ 1810 1820 1830 1840 1850 1860 SKLYHLPPPT VGPHSIASPP EDRTVKDSTP SSLDSDPLMA MLLKLQEAAN YIESPDRETI LDPNLQATL
	Isoform 3 [UniParc]. Checksum: 1FC2BE3E0AA00D08	FASTA	1,874	202,080
	10 20 30 40 50 60 MLGSSVKSVQ PEVELSSGGG DEGADEPRGA GRKAAAADGR GMLPKRAKAP GGGGGMAKAS 70 80 90 100 110 120 AAELKVFKSG SVDSRVPGGP PASNLRKQKS LTNLSFLTDS EKKLQLYEPE WSDDMAKAPK 130 140 150 160 170 180 GLGKVGSKGR EAPLMSKTLS KSEHSLFQAK GSPAGGAKTP LAPLAPNLGK PSRIPRGPYA 190 200 210 220 230 240 EVKPLSKAPE AAVSEDGKSD DELLSSKAKA QKSSGPVPSA KGQEERAFLK VDPELVVTVL 250 260 270 280 290 300 GDLEQLLFSQ MLDPESQRKR TVQNVLDLRQ NLEETMSSLR GSQVTHSSLE MTCYDSDDAN 310 320 330 340 350 360 PRSVSSLSNR SSPLSWRYGQ SSPRLQAGDA PSVGGSCRSE GTPAWYMHGE RAHYSHTMPM 370 380 390 400 410 420 RSPSKLSHIS RLELVESLDS DEVDLKSGYM SDSDLMGKTM TEDDDITTGW DESSSISSGL 430 440 450 460 470 480 SDASDNLSSE EFNASSSLNS LPSTPTASRR NSTIVLRTDS EKRSLAESGL SWFSESEEKA 490 500 510 520 530 540 PKKLEYDSGS LKMEPGTSKW RRERPESCDD SSKGGELKKP ISLGHPGSLK KGKTPPVAVT 550 560 570 580 590 600 SPITHTAQSA LKVAGKPEGK ATDKGKLAVK NTGLQRSSSD AGRDRLSDAK KPPSGIARPS 610 620 630 640 650 660 TSGSFGYKKP PPATGTATVM QTGGSATLSK IQKSSGIPVK PVNGRKTSLD VSNSAEPGFL 670 680 690 700 710 720 APGARSNIQY RSLPRPAKSS SMSVTGGRGG PRPVSSSIDP SLLSTKQGGL TPSRLKEPTK 730 740 750 760 770 780 VASGRTTPAP VNQTDREKEK AKAKAVALDS DNISLKSIGS PESTPKNQAS HPTATKLAEL 790 800 810 820 830 840 PPTPLRATAK SFVKPPSLAN LDKVNSNSLD LPSSSDTTHA SKVPDLHATS SASGGPLPSC 850 860 870 880 890 900 FTPSPAPILN INSASFSQGL ELMSGFSVPK ETRMYPKLSG LHRSMESLQM PMSLPSAFPS 910 920 930 940 950 960 STPVPTPPAP PAAPTEEETE ELTWSGSPRA GQLDSNQRDR NTLPKKGLRY QLQSQEETKE 970 980 990 1000 1010 1020 RRHSHTIGGL PESDDQSELP SPPALPMSLS AKGQLTNIVS PTAATTPRIT RSNSIPTHEA 1030 1040 1050 1060 1070 1080 AFELYSGSQM GSTLSLAERP KGMIRSGSFR DPTDDVHGSV LSLASSASST YSSAEERMQS 1090 1100 1110 1120 1130 1140 EQIRKLRREL ESSQEKVATL TSQLSANANL VAAFEQSLVN MTSRLRHLAE TAEEKDTELL 1150 1160 1170 1180 1190 1200 DLRETIDFLK KKNSEAQAVI QGALNASETT PKELRIKRQN SSDSISSLNS ITSHSSIGSS 1210 1220 1230 1240 1250 1260 KDADAKKKKK KSWLRSSFNK AFSIKKGPKS ASSYSDIEEI ATPDSSAPSS PKLQHGSTET 1270 1280 1290 1300 1310 1320 ASPSIKSSTS SSVGTDVTEG PAHPAPHTRL FHANEEEEPE KKEVSELRSE LWEKEMKLTD 1330 1340 1350 1360 1370 1380 IRLEALNSAH QLDQLRETMH NMQLEVDLLK AENDRLKVAP GPSSGSTPGQ VPGSSALSSP 1390 1400 1410 1420 1430 1440 RRSLGLALTH SFGPSLADTD LSPMDGISTC GPKEEVTLRV VVRMPPQHII KGDLKQQEFF 1450 1460 1470 1480 1490 1500 LGCSKVSGKV DWKMLDEAVF QVFKDYISKM DPASTLGLST ESIHGYSISH VKRVLDAEPP 1510 1520 1530 1540 1550 1560 EMPPCRRGVN NISVSLKGLK EKCVDSLVFE TLIPKPMMQH YISLLLKHRR LVLSGPSGTG 1570 1580 1590 1600 1610 1620 KTYLTNRLAE YLVERSGREV TEGIVSTFNM HQQSCKDLQL YLSNLANQID RETGIGDVPL 1630 1640 1650 1660 1670 1680 VILLDDLSEA GSISELVNGA LTCKYHKCPY IIGTTNQPVK MTPNHGLHLS FRMLTFSNNV 1690 1700 1710 1720 1730 1740 EPANGFLVRY LRRKLVESDS DINANKEELL RVLDWVPKLW YHLHTFLEKH STSDFLIGPC 1750 1760 1770 1780 1790 1800 FFLSCPIGIE DFRTWFIDLW NNSIIPYLQE GAKDGIKVHG QKAAWEDPVE WVRDTLPWPS 1810 1820 1830 1840 1850 1860 AQQDQSKLYH LPPPTVGPHS IASPPEDRTV KDSTPSSLDS DPLMAMLLKL QEAANYIESP 1870 DRETILDPNL QATL
	Isoform 4 [UniParc]. Checksum: 40D22F058C3DDFBA	FASTA	1,817	196,001
	10 20 30 40 50 60 MLGSSVKSVQ PEVELSSGGG DEGADEPRGA GRKAAAADGR GMLPKRAKAP GGGGGMAKAS 70 80 90 100 110 120 AAELKVFKSG SVDSRVPGGP PASNLRKQKS LTNLSFLTDS EKKLQLYEPE WSDDMAKAPK 130 140 150 160 170 180 GLGKVGSKGR EAPLMSKTLS KSEHSLFQAK GSPAGGAKTP LAPLAPNLGK PSRIPRGPYA 190 200 210 220 230 240 EVKPLSKAPE AAVSEDGKSD DELLSSKAKA QKSSGPVPSA KGQEERAFLK VDPELVVTVL 250 260 270 280 290 300 GDLEQLLFSQ MLDPESQRKR TVQNVLDLRQ NLEETMSSLR GSQVTHSSLE MTCYDSDDAN 310 320 330 340 350 360 PRSVSSLSNR SSPLSWRYGQ SSPRLQAGDA PSVGGSCRSE GTPAWYMHGE RAHYSHTMPM 370 380 390 400 410 420 RSPSKLSHIS RLELVESLDS DEVDLKSGYM SDSDLMGKTM TEDDDITTGW DESSSISSGL 430 440 450 460 470 480 SDASDNLSSE EFNASSSLNS LPSTPTASRR NSTIVLRTDS EKRSLAESGL SWFSESEEKA 490 500 510 520 530 540 PKKLEYDSGS LKMEPGTSKW RRERPESCDD SSKGGELKKP ISLGHPGSLK KGKTPPVAVT 550 560 570 580 590 600 SPITHTAQSA LKVAGKPEGK ATDKGKLAVK NTGLQRSSSD AGRDRLSDAK KPPSGIARPS 610 620 630 640 650 660 TSGSFGYKKP PPATGTATVM QTGGSATLSK IQKSSGIPVK PVNGRKTSLD VSNSAEPGFL 670 680 690 700 710 720 APGARSNIQY RSLPRPAKSS SMSVTGGRGG PRPVSSSIDP SLLSTKQGGL TPSRLKEPTK 730 740 750 760 770 780 VASGRTTPAP VNQTDREKEK AKAKAVALDS DNISLKSIGS PESTPKNQAS HPTATKLAEL 790 800 810 820 830 840 PPTPLRATAK SFVKPPSLAN LDKVNSNSLD LPSSSDTTHA SKVPDLHATS SASGGPLPSC 850 860 870 880 890 900 FTPSPAPILN INSASFSQGL ELMSGFSVPK ETRMYPKLSG LHRSMESLQM PMSLPSAFPS 910 920 930 940 950 960 STPVPTPPAP PAAPTEEETE ELTWSGSPRA GQLDSNQRDR NTLPKKGLRY QLQSQEETKE 970 980 990 1000 1010 1020 RRHSHTIGGL PESDDQSELP SPPALPMSLS AKGQLTNIVH GSVLSLASSA SSTYSSAEER 1030 1040 1050 1060 1070 1080 MQSEQIRKLR RELESSQEKV ATLTSQLSAN ANLVAAFEQS LVNMTSRLRH LAETAEEKDT 1090 1100 1110 1120 1130 1140 ELLDLRETID FLKKKNSEAQ AVIQGALNAS ETTPKELRIK RQNSSDSISS LNSITSHSSI 1150 1160 1170 1180 1190 1200 GSSKDADAKK KKKKSWLRSS FNKAFSIKKG PKSASSYSDI EEIATPDSSA PSSPKLQHGS 1210 1220 1230 1240 1250 1260 TETASPSIKS STSSSVGTDV TEGPAHPAPH TRLFHANEEE EPEKKEVSEL RSELWEKEMK 1270 1280 1290 1300 1310 1320 LTDIRLEALN SAHQLDQLRE TMHNMQLEVD LLKAENDRLK VAPGPSSGST PGQVPGSSAL 1330 1340 1350 1360 1370 1380 SSPRRSLGLA LTHSFGPSLA DTDLSPMDGI STCGPKEEVT LRVVVRMPPQ HIIKGDLKQQ 1390 1400 1410 1420 1430 1440 EFFLGCSKVS GKVDWKMLDE AVFQVFKDYI SKMDPASTLG LSTESIHGYS ISHVKRVLDA 1450 1460 1470 1480 1490 1500 EPPEMPPCRR GVNNISVSLK GLKEKCVDSL VFETLIPKPM MQHYISLLLK HRRLVLSGPS 1510 1520 1530 1540 1550 1560 GTGKTYLTNR LAEYLVERSG REVTEGIVST FNMHQQSCKD LQLYLSNLAN QIDRETGIGD 1570 1580 1590 1600 1610 1620 VPLVILLDDL SEAGSISELV NGALTCKYHK CPYIIGTTNQ PVKMTPNHGL HLSFRMLTFS 1630 1640 1650 1660 1670 1680 NNVEPANGFL VRYLRRKLVE SDSDINANKE ELLRVLDWVP KLWYHLHTFL EKHSTSDFLI 1690 1700 1710 1720 1730 1740 GPCFFLSCPI GIEDFRTWFI DLWNNSIIPY LQEGAKDGIK VHGQKAAWED PVEWVRDTLP 1750 1760 1770 1780 1790 1800 WPSAQQDQSK LYHLPPPTVG PHSIASPPED RTVKDSTPSS LDSDPLMAML LKLQEAANYI 1810 ESPDRETILD PNLQATL
	Isoform 5 [UniParc]. Checksum: 9346E723EDFBB5F8	FASTA	1,483	160,773
	10 20 30 40 50 60 MLHLPLPRSG RTVNFPRSWD ESSSISSGLS DASDNLSSEE FNASSSLNSL PSTPTASRRN 70 80 90 100 110 120 STIVLRTDSE KRSLAESGLS WFSESEEKAP KKLEYDSGSL KMEPGTSKWR RERPESCDDS 130 140 150 160 170 180 SKGGELKKPI SLGHPGSLKK GKTPPVAVTS PITHTAQSAL KVAGKPEGKA TDKGKLAVKN 190 200 210 220 230 240 TGLQRSSSDA GRDRLSDAKK PPSGIARPST SGSFGYKKPP PATGTATVMQ TGGSATLSKI 250 260 270 280 290 300 QKSSGIPVKP VNGRKTSLDV SNSAEPGFLA PGARSNIQYR SLPRPAKSSS MSVTGGRGGP 310 320 330 340 350 360 RPVSSSIDPS LLSTKQGGLT PSRLKEPTKV ASGRTTPAPV NQTDREKEKA KAKAVALDSD 370 380 390 400 410 420 NISLKSIGSP ESTPKNQASH PTATKLAELP PTPLRATAKS FVKPPSLANL DKVNSNSLDL 430 440 450 460 470 480 PSSSDTTHAS KVPDLHATSS ASGGPLPSCF TPSPAPILNI NSASFSQGLE LMSGFSVPKE 490 500 510 520 530 540 TRMYPKLSGL HRSMESLQMP MSLPSAFPSS TPVPTPPAPP AAPTEEETEE LTWSGSPRAG 550 560 570 580 590 600 QLDSNQRDRN TLPKKGLRYQ LQSQEETKER RHSHTIGGLP ESDDQSELPS PPALPMSLSA 610 620 630 640 650 660 KGQLTNIVSP TAATTPRITR SNSIPTHEAA FELYSGSQMG STLSLAERPK GMIRSGSFRD 670 680 690 700 710 720 PTDDVHGSVL SLASSASSTY SSAEERMQSE QIRKLRRELE SSQEKVATLT SQLSANANLV 730 740 750 760 770 780 AAFEQSLVNM TSRLRHLAET AEEKDTELLD LRETIDFLKK KNSEAQAVIQ GALNASETTP 790 800 810 820 830 840 KELRIKRQNS SDSISSLNSI TSHSSIGSSK DADAKKKKKK SWLRSSFNKA FSIKKGPKSA 850 860 870 880 890 900 SSYSDIEEIA TPDSSAPSSP KLQHGSTETA SPSIKSSTSS SVGTDVTEGP AHPAPHTRLF 910 920 930 940 950 960 HANEEEEPEK KEVSELRSEL WEKEMKLTDI RLEALNSAHQ LDQLRETMHN MQLEVDLLKA 970 980 990 1000 1010 1020 ENDRLKVAPG PSSGSTPGQV PGSSALSSPR RSLGLALTHS FGPSLADTDL SPMDGISTCG 1030 1040 1050 1060 1070 1080 PKEEVTLRVV VRMPPQHIIK GDLKQQEFFL GCSKVSGKVD WKMLDEAVFQ VFKDYISKMD 1090 1100 1110 1120 1130 1140 PASTLGLSTE SIHGYSISHV KRVLDAEPPE MPPCRRGVNN ISVSLKGLKE KCVDSLVFET 1150 1160 1170 1180 1190 1200 LIPKPMMQHY ISLLLKHRRL VLSGPSGTGK TYLTNRLAEY LVERSGREVT EGIVSTFNMH 1210 1220 1230 1240 1250 1260 QQSCKDLQLY LSNLANQIDR ETGIGDVPLV ILLDDLSEAG SISELVNGAL TCKYHKCPYI 1270 1280 1290 1300 1310 1320 IGTTNQPVKM TPNHGLHLSF RMLTFSNNVE PANGFLVRYL RRKLVESDSD INANKEELLR 1330 1340 1350 1360 1370 1380 VLDWVPKLWY HLHTFLEKHS TSDFLIGPCF FLSCPIGIED FRTWFIDLWN NSIIPYLQEG 1390 1400 1410 1420 1430 1440 AKDGIKVHGQ KAAWEDPVEW VRDTLPWPSA QQDQSKLYHL PPPTVGPHSI ASPPEDRTVK 1450 1460 1470 1480 DSTPSSLDSD PLMAMLLKLQ EAANYIESPD RETILDPNLQ ATL
	Isoform 6 [UniParc]. Checksum: F7942947F8623765	FASTA	1,190	126,180
	10 20 30 40 50 60 MLGSSVKSVQ PEVELSSGGG DEGADEPRGA GRKAAAADGR GMLPKRAKAP GGGGGMAKAS 70 80 90 100 110 120 AAELKVFKSG SVDSRVPGGP PASNLRKQKS LTNLSFLTDS EKKLQLYEPE WSDDMAKAPK 130 140 150 160 170 180 GLGKVGSKGR EAPLMSKTLS KSEHSLFQAK GSPAGGAKTP LAPLAPNLGK PSRIPRGPYA 190 200 210 220 230 240 EVKPLSKAPE AAVSEDGKSD DELLSSKAKA QKSSGPVPSA KGQEERAFLK VDPELVVTVL 250 260 270 280 290 300 GDLEQLLFSQ MLDPESQRKR TVQNVLDLRQ NLEETMSSLR GSQVTHSSLE MTCYDSDDAN 310 320 330 340 350 360 PRSVSSLSNR SSPLSWRYGQ SSPRLQAGDA PSVGGSCRSE GTPAWYMHGE RAHYSHTMPM 370 380 390 400 410 420 RSPSKLSHIS RLELVESLDS DEVDLKSGYM SDSDLMGKTM TEDDDITTGW DESSSISSGL 430 440 450 460 470 480 SDASDNLSSE EFNASSSLNS LPSTPTASRR NSTIVLRTDS EKRSLAESGL SWFSESEEKA 490 500 510 520 530 540 PKKLEYDSGS LKMEPGTSKW RRERPESCDD SSKGGELKKP ISLGHPGSLK KGKTPPVAVT 550 560 570 580 590 600 SPITHTAQSA LKVAGKPEGK ATDKGKLAVK NTGLQRSSSD AGRDRLSDAK KPPSGIARPS 610 620 630 640 650 660 TSGSFGYKKP PPATGTATVM QTGGSATLSK IQKSSGIPVK PVNGRKTSLD VSNSAEPGFL 670 680 690 700 710 720 APGARSNIQY RSLPRPAKSS SMSVTGGRGG PRPVSSSIDP SLLSTKQGGL TPSRLKEPTK 730 740 750 760 770 780 VASGRTTPAP VNQTDREKEK AKAKAVALDS DNISLKSIGS PESTPKNQAS HPTATKLAEL 790 800 810 820 830 840 PPTPLRATAK SFVKPPSLAN LDKVNSNSLD LPSSSDTTHA SKVPDLHATS SASGGPLPSC 850 860 870 880 890 900 FTPSPAPILN INSASFSQGL ELMSGFSVPK ETRMYPKLSG LHRSMESLQM PMSLPSAFPS 910 920 930 940 950 960 STPVPTPPAP PAAPTEEETE ELTWSGSPRA GQLDSNQRDR NTLPKKGLRY QLQSQEETKE 970 980 990 1000 1010 1020 RRHSHTIGGL PESDDQSELP SPPALPMSLS AKGQLTNIVS PTAATTPRIT RSNSIPTHEA 1030 1040 1050 1060 1070 1080 AFELYSGSQM GSTLSLAERP KGMIRSGSFR DPTDDVHGSV LSLASSASST YSSQIRKLRR 1090 1100 1110 1120 1130 1140 ELESSQEKVA TLTSQLSANA NLVAAFEQSL VNMTSRLRHL AETAEEKDTE LLDLRETIDF 1150 1160 1170 1180 1190 LKKKNSEAQA VIQGALNASE TTPKGRTSSH RLRGNREQES KSITDFYLGP
	Isoform 7 [UniParc]. Checksum: 31EDBD0679B2F653	FASTA	1,809	195,040
	10 20 30 40 50 60 MLGSSVKSVQ PEVELSSGGG DEGADEPRGA GRKAAAADGR GMLPKRAKAP GGGGGMAKAS 70 80 90 100 110 120 AAELKVFKSG SVDSRVPGGP PASNLRKQKS LTNLSFLTDS EKKLQLYEPE WSDDMAKAPK 130 140 150 160 170 180 GLGKVGSKGR EAPLMSKTLS KSEHSLFQAK GSPAGGAKTP LAPLAPNLGK PSRIPRGPYA 190 200 210 220 230 240 EVKPLSKAPE AAVSEDGKSD DELLSSKAKA QKSSGPVPSA KGQEERAFLK VDPELVVTVL 250 260 270 280 290 300 GDLEQLLFSQ MLDPESQRKR TVQNVLDLRQ NLEETMSSLR GSQVTHSSLE MTCYDSDDAN 310 320 330 340 350 360 PRSVSSLSNR SSPLSWRYGQ SSPRLQAGDA PSVGGSCRSE GTPAWYMHGE RAHYSHTMPM 370 380 390 400 410 420 RSPSKLSHIS RLELVESLDS DEVDLKSGYM SDSDLMGKTM TEDDDITTGW DESSSISSGL 430 440 450 460 470 480 SDASDNLSSE EFNASSSLNS LPSTPTASRR NSTIVLRTDS EKRSLAESGL SWFSESEEKA 490 500 510 520 530 540 PKKLEYDSGS LKMEPGTSKW RRERPESCDD SSKGGELKKP ISLGHPGSLK KGKTPPVAVT 550 560 570 580 590 600 SPITHTAQSA LKVAGKPEGK ATDKGKLAVK NTGLQRSSSD AGRDRLSDAK KPPSGIARPS 610 620 630 640 650 660 TSGSFGYKKP PPATGTATVM QTGGSATLSK IQKSSGIPVK PVNGRKTSLD VSNSAEPGFL 670 680 690 700 710 720 APGARSNIQY RSLPRPAKSS SMSVTGGRGG PRPVSSSIDP SLLSTKQGGL TPSRLKEPTK 730 740 750 760 770 780 VASGRTTPAP VNQTDREKEK AKAKAVALDS DNISLKSIGS PESTPKNQAS HPTATKLAEL 790 800 810 820 830 840 PPTPLRATAK SFVKPPSLAN LDKVNSNSLD LPSSSDTTHA SKVPDLHATS SASGGPLPSC 850 860 870 880 890 900 FTPSPAPILN INSASFSQGL ELMSGFSVPK ETRMYPKLSG LHRSMESLQM PMSLPSAFPS 910 920 930 940 950 960 STPVPTPPAP PAAPTEEETE ELTWSGSPRA GQLDSNQRDR NTLPKKGLRY QLQSQEETKE 970 980 990 1000 1010 1020 RRHSHTIGGL PESDDQSELP SPPALPMSLS AKGQLTNIVH GSVLSLASSA SSTYSSQIRK 1030 1040 1050 1060 1070 1080 LRRELESSQE KVATLTSQLS ANANLVAAFE QSLVNMTSRL RHLAETAEEK DTELLDLRET 1090 1100 1110 1120 1130 1140 IDFLKKKNSE AQAVIQGALN ASETTPKELR IKRQNSSDSI SSLNSITSHS SIGSSKDADA 1150 1160 1170 1180 1190 1200 KKKKKKSWLR SSFNKAFSIK KGPKSASSYS DIEEIATPDS SAPSSPKLQH GSTETASPSI 1210 1220 1230 1240 1250 1260 KSSTSSSVGT DVTEGPAHPA PHTRLFHANE EEEPEKKEVS ELRSELWEKE MKLTDIRLEA 1270 1280 1290 1300 1310 1320 LNSAHQLDQL RETMHNMQLE VDLLKAENDR LKVAPGPSSG STPGQVPGSS ALSSPRRSLG 1330 1340 1350 1360 1370 1380 LALTHSFGPS LADTDLSPMD GISTCGPKEE VTLRVVVRMP PQHIIKGDLK QQEFFLGCSK 1390 1400 1410 1420 1430 1440 VSGKVDWKML DEAVFQVFKD YISKMDPAST LGLSTESIHG YSISHVKRVL DAEPPEMPPC 1450 1460 1470 1480 1490 1500 RRGVNNISVS LKGLKEKCVD SLVFETLIPK PMMQHYISLL LKHRRLVLSG PSGTGKTYLT 1510 1520 1530 1540 1550 1560 NRLAEYLVER SGREVTEGIV STFNMHQQSC KDLQLYLSNL ANQIDRETGI GDVPLVILLD 1570 1580 1590 1600 1610 1620 DLSEAGSISE LVNGALTCKY HKCPYIIGTT NQPVKMTPNH GLHLSFRMLT FSNNVEPANG 1630 1640 1650 1660 1670 1680 FLVRYLRRKL VESDSDINAN KEELLRVLDW VPKLWYHLHT FLEKHSTSDF LIGPCFFLSC 1690 1700 1710 1720 1730 1740 PIGIEDFRTW FIDLWNNSII PYLQEGAKDG IKVHGQKAAW EDPVEWVRDT LPWPSAQQDQ 1750 1760 1770 1780 1790 1800 SKLYHLPPPT VGPHSIASPP EDRTVKDSTP SSLDSDPLMA MLLKLQEAAN YIESPDRETI LDPNLQATL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms." Coy J.F., Wiemann S., Bechmann I., Baechner D., Nitsch R., Kretz O., Christiansen H., Poustka A. Gene 290:73-94(2002) [PubMed: 12062803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[2]	"Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans." Maes T., Barcelo A., Buesa C. Genomics 80:21-30(2002) [PubMed: 12079279] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-1273, TISSUE SPECIFICITY.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53." Peeters P.J., Baker A., Goris I., Daneels G., Verhasselt P., Luyten W.H.M.L., Geysen J.J.G.H., Kass S.U., Moechars D.W.E. Brain Res. Dev. Brain Res. 150:89-101(2004) [PubMed: 15158073] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-409, NUCLEOTIDE SEQUENCE [MRNA] OF 42-1877 (ISOFORM 1).
[5]	"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain." Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O. DNA Res. 6:329-336(1999) [PubMed: 10574461] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 108-1877 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 707-1877 (ISOFORM 6). Tissue: Brain.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 445-1205 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1161-1877 (ISOFORM 3).
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1122-1877 (ISOFORM 3). Tissue: Skin.
[8]	"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-726, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152; THR-159; SER-199; SER-296; SER-308; SER-311; SER-391; SER-452; THR-534; SER-541; THR-572; SER-760; SER-808; THR-1170; SER-1181 AND SER-1382, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-391; SER-760; SER-1000; THR-1002; SER-1253 AND SER-1382, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[11]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-750, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY043013 mRNA. Translation: AAL05591.1. AL512788, AC092800, AL645504 Genomic DNA. Translation: CAH71925.1. Sequence problems. AL645504, AC092800, AL512788 Genomic DNA. Translation: CAI17010.1. Sequence problems. AL645504 Genomic DNA. Translation: CAI17011.1. AL645504 Genomic DNA. Translation: CAI17012.1. AL645504 Genomic DNA. Translation: CAI17013.1. AL645504, AC092800 Genomic DNA. Translation: CAI17014.1. AC096677 Genomic DNA. No translation available. AJ251973 Genomic DNA. Translation: CAB66088.1. AJ488101 mRNA. Translation: CAD32470.1. AB032977 mRNA. Translation: BAA86465.3. AB033039 mRNA. Translation: BAA86527.1. AK022622 mRNA. Translation: BAB14136.1. Different initiation. AK022631 mRNA. Translation: BAB14142.1. Different initiation. AK024265 mRNA. Translation: BAB14865.1. Different initiation. BC007523 mRNA. Translation: AAH07523.1. Different initiation.
IPI	IPI00171636. IPI00550839. IPI00641075. IPI00641137. IPI00845310. IPI00845401. IPI00845471.
RefSeq	NP_001161210.1. NM_001167738.1. NP_065176.3. NM_020443.4.
UniGene	Hs.585374.
3D structure databases
ProteinModelPortal	Q8NEY1.
SMR	Q8NEY1. Positions 1554-1646.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NEY1. 2 interactions.
STRING	Q8NEY1.
PTM databases
PhosphoSite	Q8NEY1.
Polymorphism databases
DMDM	147704557.
Proteomic databases
PRIDE	Q8NEY1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000367296; ENSP00000356265; ENSG00000134369.
GeneID	89796.
KEGG	hsa:89796.
UCSC	uc001gwu.2. human. uc001gwx.2. human.
Organism-specific databases
CTD	89796.
GeneCards	GC01P201595.
H-InvDB	HIX0001462.
HGNC	HGNC:15989. NAV1.
HPA	CAB012302. HPA018127. HPA027887.
MIM	611628. gene.
neXtProt	NX_Q8NEY1.
PharmGKB	PA31451.
HUGE	Search... Search...
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00530000063334.
HOVERGEN	HBG058814.
InParanoid	Q8NEY1.
OMA	ETEELTW.
PhylomeDB	Q8NEY1.
Gene expression databases
ArrayExpress	Q8NEY1.
Bgee	Q8NEY1.
Genevestigator	Q8NEY1.
Family and domain databases
InterPro	IPR003593. ATPase_AAA+_core. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	76289.
SOURCE	Search...

Entry information

Entry name

NAV1_HUMAN

Accession

Primary (citable) accession number: Q8NEY1
Secondary accession number(s): A8MS88 , Q5SVH1, Q5SVH2, Q5SVH3, Q5SVH7, Q5VUY9, Q8IVL2, Q96II1, Q9H7V9, Q9H9S9, Q9H9T5, Q9UGI1, Q9ULK7, Q9ULR9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 15, 2007
Last modified:	January 25, 2012
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.