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Protein

Short-chain dehydrogenase/reductase family 9C member 7

Gene

SDR9C7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Displays weak conversion of all-trans-retinal to all-trans-retinol in the presence of NADH. Has apparently no steroid dehydrogenase activity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei160 – 1601SubstrateBy similarity
Active sitei172 – 1721Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 5325NADPBy similarityAdd
BLAST

GO - Molecular functioni

  • retinol dehydrogenase activity Source: UniProtKB

GO - Biological processi

  • oxidation-reduction process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiR-HSA-2453902. The canonical retinoid cycle in rods (twilight vision).

Names & Taxonomyi

Protein namesi
Recommended name:
Short-chain dehydrogenase/reductase family 9C member 7 (EC:1.1.1.-)
Alternative name(s):
Orphan short-chain dehydrogenase/reductase
Short name:
SDR-O
RDH-S
Gene namesi
Name:SDR9C7
Synonyms:RDHS, SDRO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:29958. SDR9C7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164725648.

Polymorphism and mutation databases

BioMutaiSDR9C7.
DMDMi74751264.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Short-chain dehydrogenase/reductase family 9C member 7PRO_0000316885Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei185 – 1851PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8NEX9.
PRIDEiQ8NEX9.

PTM databases

iPTMnetiQ8NEX9.
PhosphoSiteiQ8NEX9.

Expressioni

Tissue specificityi

Highly expressed in liver.1 Publication

Gene expression databases

BgeeiQ8NEX9.
GenevisibleiQ8NEX9. HS.

Organism-specific databases

HPAiHPA039059.

Interactioni

Protein-protein interaction databases

BioGridi125711. 12 interactions.
STRINGi9606.ENSP00000293502.

Structurei

3D structure databases

ProteinModelPortaliQ8NEX9.
SMRiQ8NEX9. Positions 28-277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
GeneTreeiENSGT00840000129713.
InParanoidiQ8NEX9.
OMAiCHAFVPL.
OrthoDBiEOG7FXZZX.
PhylomeDBiQ8NEX9.
TreeFamiTF325617.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NEX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALTDLSFM YRWFKNCNLV GNLSEKYVFI TGCDSGFGNL LAKQLVDRGM
60 70 80 90 100
QVLAACFTEE GSQKLQRDTS YRLQTTLLDV TKSESIKAAA QWVRDKVGEQ
110 120 130 140 150
GLWALVNNAG VGLPSGPNEW LTKDDFVKVI NVNLVGLIEV TLHMLPMVKR
160 170 180 190 200
ARGRVVNMSS SGGRVAVIGG GYCVSKFGVE AFSDSIRREL YYFGVKVCII
210 220 230 240 250
EPGNYRTAIL GKENLESRMR KLWERLPQET RDSYGEDYFR IYTDKLKNIM
260 270 280 290 300
QVAEPRVRDV INSMEHAIVS RSPRIRYNPG LDAKLLYIPL AKLPTPVTDF
310
ILSRYLPRPA DSV
Length:313
Mass (Da):35,263
Last modified:October 1, 2002 - v1
Checksum:iC60949797F23D05E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044434 mRNA. Translation: AAK95856.1.
AK122782 mRNA. Translation: BAG53726.1.
CH471054 Genomic DNA. Translation: EAW96967.1.
BC101551 mRNA. Translation: AAI01552.1.
BC101553 mRNA. Translation: AAI01554.1.
CCDSiCCDS8926.1.
RefSeqiNP_683695.1. NM_148897.2.
UniGeneiHs.380178.

Genome annotation databases

EnsembliENST00000293502; ENSP00000293502; ENSG00000170426.
GeneIDi121214.
KEGGihsa:121214.
UCSCiuc010sqw.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044434 mRNA. Translation: AAK95856.1.
AK122782 mRNA. Translation: BAG53726.1.
CH471054 Genomic DNA. Translation: EAW96967.1.
BC101551 mRNA. Translation: AAI01552.1.
BC101553 mRNA. Translation: AAI01554.1.
CCDSiCCDS8926.1.
RefSeqiNP_683695.1. NM_148897.2.
UniGeneiHs.380178.

3D structure databases

ProteinModelPortaliQ8NEX9.
SMRiQ8NEX9. Positions 28-277.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125711. 12 interactions.
STRINGi9606.ENSP00000293502.

PTM databases

iPTMnetiQ8NEX9.
PhosphoSiteiQ8NEX9.

Polymorphism and mutation databases

BioMutaiSDR9C7.
DMDMi74751264.

Proteomic databases

PaxDbiQ8NEX9.
PRIDEiQ8NEX9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293502; ENSP00000293502; ENSG00000170426.
GeneIDi121214.
KEGGihsa:121214.
UCSCiuc010sqw.2. human.

Organism-specific databases

CTDi121214.
GeneCardsiSDR9C7.
HGNCiHGNC:29958. SDR9C7.
HPAiHPA039059.
MIMi609769. gene.
neXtProtiNX_Q8NEX9.
PharmGKBiPA164725648.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
GeneTreeiENSGT00840000129713.
InParanoidiQ8NEX9.
OMAiCHAFVPL.
OrthoDBiEOG7FXZZX.
PhylomeDBiQ8NEX9.
TreeFamiTF325617.

Enzyme and pathway databases

ReactomeiR-HSA-2453902. The canonical retinoid cycle in rods (twilight vision).

Miscellaneous databases

GenomeRNAii121214.
NextBioi80677.
PROiQ8NEX9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NEX9.
GenevisibleiQ8NEX9. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SDR-O: an orphan short-chain dehydrogenase/reductase localized at mouse chromosome 10/human chromosome 12."
    Chen W., Song M.-S., Napoli J.L.
    Gene 294:141-146(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Fetal liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Esophagus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  5. Cited for: NOMENCLATURE.
  6. "In search for function of two human orphan SDR enzymes: Hydroxysteroid dehydrogenase like 2 (HSDL2) and short-chain dehydrogenase/reductase-orphan (SDR-O)."
    Kowalik D., Haller F., Adamski J., Moeller G.
    J. Steroid Biochem. Mol. Biol. 117:117-124(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-185, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiDR9C7_HUMAN
AccessioniPrimary (citable) accession number: Q8NEX9
Secondary accession number(s): B3KVB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.