ID   WFDC9_HUMAN             Reviewed;          89 AA.
AC   Q8NEX5; Q3MIX6; Q5TGZ8;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 138.
DE   RecName: Full=Protein WFDC9;
DE   Flags: Precursor;
GN   Name=WFDC9; Synonyms=WAP9;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12206714; DOI=10.1042/bj20020869;
RA   Clauss A., Lilja H., Lundwall A.;
RT   "A locus on human chromosome 20 contains several genes expressing protease
RT   inhibitor domains with homology to whey acidic protein.";
RL   Biochem. J. 368:233-242(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Cerebellum;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q8NEX5; P50222: MEOX2; NbExp=3; IntAct=EBI-10270812, EBI-748397;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- MISCELLANEOUS: Although this protein was isolated in a region
CC       containing several WAP proteins and was defined as a WAP protein, it
CC       does not contain a classical WAP domain.
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DR   EMBL; AY047610; AAK97772.1; -; mRNA.
DR   EMBL; AL031671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC069295; AAH69295.1; -; mRNA.
DR   EMBL; BC101652; AAI01653.1; -; mRNA.
DR   EMBL; BC101656; AAI01657.1; -; mRNA.
DR   CCDS; CCDS13362.1; -.
DR   RefSeq; NP_671731.1; NM_147198.3.
DR   AlphaFoldDB; Q8NEX5; -.
DR   BioGRID; 129232; 12.
DR   IntAct; Q8NEX5; 4.
DR   STRING; 9606.ENSP00000320532; -.
DR   iPTMnet; Q8NEX5; -.
DR   PhosphoSitePlus; Q8NEX5; -.
DR   BioMuta; WFDC9; -.
DR   DMDM; 26401304; -.
DR   MassIVE; Q8NEX5; -.
DR   PaxDb; 9606-ENSP00000320532; -.
DR   PeptideAtlas; Q8NEX5; -.
DR   ProteomicsDB; 73227; -.
DR   Antibodypedia; 53788; 31 antibodies from 5 providers.
DR   DNASU; 259240; -.
DR   Ensembl; ENST00000326000.2; ENSP00000320532.1; ENSG00000180205.4.
DR   GeneID; 259240; -.
DR   KEGG; hsa:259240; -.
DR   MANE-Select; ENST00000326000.2; ENSP00000320532.1; NM_147198.4; NP_671731.1.
DR   UCSC; uc002xoy.3; human.
DR   AGR; HGNC:20380; -.
DR   CTD; 259240; -.
DR   GeneCards; WFDC9; -.
DR   HGNC; HGNC:20380; WFDC9.
DR   HPA; ENSG00000180205; Tissue enriched (epididymis).
DR   neXtProt; NX_Q8NEX5; -.
DR   PharmGKB; PA134934414; -.
DR   VEuPathDB; HostDB:ENSG00000180205; -.
DR   eggNOG; ENOG502TGNJ; Eukaryota.
DR   GeneTree; ENSGT00940000162961; -.
DR   HOGENOM; CLU_191873_0_0_1; -.
DR   InParanoid; Q8NEX5; -.
DR   OMA; IEQCWVQ; -.
DR   OrthoDB; 4720156at2759; -.
DR   PhylomeDB; Q8NEX5; -.
DR   TreeFam; TF338513; -.
DR   PathwayCommons; Q8NEX5; -.
DR   SignaLink; Q8NEX5; -.
DR   BioGRID-ORCS; 259240; 43 hits in 1096 CRISPR screens.
DR   ChiTaRS; WFDC9; human.
DR   GenomeRNAi; 259240; -.
DR   Pharos; Q8NEX5; Tdark.
DR   PRO; PR:Q8NEX5; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   RNAct; Q8NEX5; Protein.
DR   Bgee; ENSG00000180205; Expressed in corpus epididymis and 18 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   Genevisible; Q8NEX5; HS.
PE   1: Evidence at protein level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..89
FT                   /note="Protein WFDC9"
FT                   /id="PRO_0000041385"
FT   VARIANT         27
FT                   /note="N -> T (in dbSNP:rs2245898)"
FT                   /id="VAR_021911"
SQ   SEQUENCE   89 AA;  10506 MW;  9CC9B2013FA679EB CRC64;
     MKPWILLLVM FISGVVMLLP VLGSFWNKDP FLDMIRETEQ CWVQPPYKYC EKRCTKIMTC
     VRPNHTCCWT YCGNICLDNE EPLKSMLNP
//