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Q8NEX5

- WFDC9_HUMAN

UniProt

Q8NEX5 - WFDC9_HUMAN

Protein

Protein WFDC9

Gene

WFDC9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein WFDC9
    Gene namesi
    Name:WFDC9
    Synonyms:WAP9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:20380. WFDC9.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134934414.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 8966Protein WFDC9PRO_0000041385Add
    BLAST

    Proteomic databases

    PRIDEiQ8NEX5.

    PTM databases

    PhosphoSiteiQ8NEX5.

    Expressioni

    Gene expression databases

    BgeeiQ8NEX5.
    CleanExiHS_WFDC9.
    GenevestigatoriQ8NEX5.

    Organism-specific databases

    HPAiHPA052506.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000320532.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NEX5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG87139.
    HOGENOMiHOG000231001.
    HOVERGENiHBG058740.
    InParanoidiQ8NEX5.
    OMAiATHINGW.
    OrthoDBiEOG72RN1W.
    PhylomeDBiQ8NEX5.
    TreeFamiTF338513.

    Family and domain databases

    InterProiIPR020310. WFDC9/WFDC11.
    [Graphical view]
    ProDomiPD288743. WFDC9_WDFC11. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8NEX5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKPWILLLVM FISGVVMLLP VLGSFWNKDP FLDMIRETEQ CWVQPPYKYC   50
    EKRCTKIMTC VRPNHTCCWT YCGNICLDNE EPLKSMLNP 89
    Length:89
    Mass (Da):10,506
    Last modified:October 1, 2002 - v1
    Checksum:i9CC9B2013FA679EB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti27 – 271N → T.
    Corresponds to variant rs2245898 [ dbSNP | Ensembl ].
    VAR_021911

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY047610 mRNA. Translation: AAK97772.1.
    AL031671 Genomic DNA. Translation: CAI22432.1.
    BC069295 mRNA. Translation: AAH69295.1.
    BC101652 mRNA. Translation: AAI01653.1.
    BC101656 mRNA. Translation: AAI01657.1.
    CCDSiCCDS13362.1.
    RefSeqiNP_671731.1. NM_147198.3.
    UniGeneiHs.249828.

    Genome annotation databases

    EnsembliENST00000326000; ENSP00000320532; ENSG00000180205.
    GeneIDi259240.
    KEGGihsa:259240.
    UCSCiuc002xoy.3. human.

    Polymorphism databases

    DMDMi26401304.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY047610 mRNA. Translation: AAK97772.1 .
    AL031671 Genomic DNA. Translation: CAI22432.1 .
    BC069295 mRNA. Translation: AAH69295.1 .
    BC101652 mRNA. Translation: AAI01653.1 .
    BC101656 mRNA. Translation: AAI01657.1 .
    CCDSi CCDS13362.1.
    RefSeqi NP_671731.1. NM_147198.3.
    UniGenei Hs.249828.

    3D structure databases

    ProteinModelPortali Q8NEX5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000320532.

    PTM databases

    PhosphoSitei Q8NEX5.

    Polymorphism databases

    DMDMi 26401304.

    Proteomic databases

    PRIDEi Q8NEX5.

    Protocols and materials databases

    DNASUi 259240.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326000 ; ENSP00000320532 ; ENSG00000180205 .
    GeneIDi 259240.
    KEGGi hsa:259240.
    UCSCi uc002xoy.3. human.

    Organism-specific databases

    CTDi 259240.
    GeneCardsi GC20M044236.
    HGNCi HGNC:20380. WFDC9.
    HPAi HPA052506.
    neXtProti NX_Q8NEX5.
    PharmGKBi PA134934414.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG87139.
    HOGENOMi HOG000231001.
    HOVERGENi HBG058740.
    InParanoidi Q8NEX5.
    OMAi ATHINGW.
    OrthoDBi EOG72RN1W.
    PhylomeDBi Q8NEX5.
    TreeFami TF338513.

    Miscellaneous databases

    GenomeRNAii 259240.
    NextBioi 93082.
    PROi Q8NEX5.

    Gene expression databases

    Bgeei Q8NEX5.
    CleanExi HS_WFDC9.
    Genevestigatori Q8NEX5.

    Family and domain databases

    InterProi IPR020310. WFDC9/WFDC11.
    [Graphical view ]
    ProDomi PD288743. WFDC9_WDFC11. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein."
      Clauss A., Lilja H., Lundwall A.
      Biochem. J. 368:233-242(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.

    Entry informationi

    Entry nameiWFDC9_HUMAN
    AccessioniPrimary (citable) accession number: Q8NEX5
    Secondary accession number(s): Q3MIX6, Q5TGZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Although this protein was isolated in a region containing several WAP proteins and was defined as a WAP protein, it does not contain a classical WAP domain.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3