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Q8NEX5 (WFDC9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein WFDC9
Gene names
Name:WFDC9
Synonyms:WAP9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length89 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Potential.

Miscellaneous

Although this protein was isolated in a region containing several WAP proteins and was defined as a WAP protein, it does not contain a classical WAP domain.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 8966Protein WFDC9
PRO_0000041385

Natural variations

Natural variant271N → T.
Corresponds to variant rs2245898 [ dbSNP | Ensembl ].
VAR_021911

Sequences

Sequence LengthMass (Da)Tools
Q8NEX5 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 9CC9B2013FA679EB

FASTA8910,506
        10         20         30         40         50         60 
MKPWILLLVM FISGVVMLLP VLGSFWNKDP FLDMIRETEQ CWVQPPYKYC EKRCTKIMTC 

        70         80 
VRPNHTCCWT YCGNICLDNE EPLKSMLNP 

« Hide

References

« Hide 'large scale' references
[1]"A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein."
Clauss A., Lilja H., Lundwall A.
Biochem. J. 368:233-242(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cerebellum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY047610 mRNA. Translation: AAK97772.1.
AL031671 Genomic DNA. Translation: CAI22432.1.
BC069295 mRNA. Translation: AAH69295.1.
BC101652 mRNA. Translation: AAI01653.1.
BC101656 mRNA. Translation: AAI01657.1.
RefSeqNP_671731.1. NM_147198.3.
UniGeneHs.249828.

3D structure databases

ProteinModelPortalQ8NEX5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000320532.

PTM databases

PhosphoSiteQ8NEX5.

Polymorphism databases

DMDM26401304.

Proteomic databases

PRIDEQ8NEX5.

Protocols and materials databases

DNASU259240.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000326000; ENSP00000320532; ENSG00000180205.
GeneID259240.
KEGGhsa:259240.
UCSCuc002xoy.3. human.

Organism-specific databases

CTD259240.
GeneCardsGC20M044236.
HGNCHGNC:20380. WFDC9.
HPAHPA052506.
neXtProtNX_Q8NEX5.
PharmGKBPA134934414.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG87139.
HOGENOMHOG000231001.
HOVERGENHBG058740.
InParanoidQ8NEX5.
OMAIEQCWVQ.
OrthoDBEOG72RN1W.
PhylomeDBQ8NEX5.
TreeFamTF338513.

Gene expression databases

BgeeQ8NEX5.
CleanExHS_WFDC9.
GenevestigatorQ8NEX5.

Family and domain databases

InterProIPR020310. Uncharacterised_WFDC.
[Graphical view]
ProDomPD288743. WFDC9_WDFC11. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

GenomeRNAi259240.
NextBio93082.
PROQ8NEX5.

Entry information

Entry nameWFDC9_HUMAN
AccessionPrimary (citable) accession number: Q8NEX5
Secondary accession number(s): Q3MIX6, Q5TGZ8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: October 1, 2002
Last modified: February 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM