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Protein

Protein WFDC9

Gene

WFDC9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein WFDC9
Gene namesi
Name:WFDC9
Synonyms:WAP9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:20380. WFDC9.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134934414.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 8966Protein WFDC9PRO_0000041385Add
BLAST

Proteomic databases

PRIDEiQ8NEX5.

PTM databases

PhosphoSiteiQ8NEX5.

Expressioni

Gene expression databases

BgeeiQ8NEX5.
CleanExiHS_WFDC9.
GenevestigatoriQ8NEX5.

Organism-specific databases

HPAiHPA052506.

Interactioni

Protein-protein interaction databases

BioGridi129232. 1 interaction.
STRINGi9606.ENSP00000320532.

Structurei

3D structure databases

ProteinModelPortaliQ8NEX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG87139.
GeneTreeiENSGT00760000119411.
HOGENOMiHOG000231001.
HOVERGENiHBG058740.
InParanoidiQ8NEX5.
OMAiIEQCWVQ.
OrthoDBiEOG72RN1W.
PhylomeDBiQ8NEX5.
TreeFamiTF338513.

Family and domain databases

InterProiIPR029725. WFDC9.
IPR020310. WFDC9/WFDC11.
[Graphical view]
PANTHERiPTHR19441:SF16. PTHR19441:SF16. 1 hit.
ProDomiPD288743. WFDC9_WDFC11. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NEX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPWILLLVM FISGVVMLLP VLGSFWNKDP FLDMIRETEQ CWVQPPYKYC
60 70 80
EKRCTKIMTC VRPNHTCCWT YCGNICLDNE EPLKSMLNP
Length:89
Mass (Da):10,506
Last modified:September 30, 2002 - v1
Checksum:i9CC9B2013FA679EB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271N → T.
Corresponds to variant rs2245898 [ dbSNP | Ensembl ].
VAR_021911

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY047610 mRNA. Translation: AAK97772.1.
AL031671 Genomic DNA. Translation: CAI22432.1.
BC069295 mRNA. Translation: AAH69295.1.
BC101652 mRNA. Translation: AAI01653.1.
BC101656 mRNA. Translation: AAI01657.1.
CCDSiCCDS13362.1.
RefSeqiNP_671731.1. NM_147198.3.
UniGeneiHs.249828.

Genome annotation databases

EnsembliENST00000326000; ENSP00000320532; ENSG00000180205.
GeneIDi259240.
KEGGihsa:259240.
UCSCiuc002xoy.3. human.

Polymorphism databases

DMDMi26401304.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY047610 mRNA. Translation: AAK97772.1.
AL031671 Genomic DNA. Translation: CAI22432.1.
BC069295 mRNA. Translation: AAH69295.1.
BC101652 mRNA. Translation: AAI01653.1.
BC101656 mRNA. Translation: AAI01657.1.
CCDSiCCDS13362.1.
RefSeqiNP_671731.1. NM_147198.3.
UniGeneiHs.249828.

3D structure databases

ProteinModelPortaliQ8NEX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129232. 1 interaction.
STRINGi9606.ENSP00000320532.

PTM databases

PhosphoSiteiQ8NEX5.

Polymorphism databases

DMDMi26401304.

Proteomic databases

PRIDEiQ8NEX5.

Protocols and materials databases

DNASUi259240.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326000; ENSP00000320532; ENSG00000180205.
GeneIDi259240.
KEGGihsa:259240.
UCSCiuc002xoy.3. human.

Organism-specific databases

CTDi259240.
GeneCardsiGC20M044236.
HGNCiHGNC:20380. WFDC9.
HPAiHPA052506.
neXtProtiNX_Q8NEX5.
PharmGKBiPA134934414.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG87139.
GeneTreeiENSGT00760000119411.
HOGENOMiHOG000231001.
HOVERGENiHBG058740.
InParanoidiQ8NEX5.
OMAiIEQCWVQ.
OrthoDBiEOG72RN1W.
PhylomeDBiQ8NEX5.
TreeFamiTF338513.

Miscellaneous databases

GenomeRNAii259240.
NextBioi93082.
PROiQ8NEX5.

Gene expression databases

BgeeiQ8NEX5.
CleanExiHS_WFDC9.
GenevestigatoriQ8NEX5.

Family and domain databases

InterProiIPR029725. WFDC9.
IPR020310. WFDC9/WFDC11.
[Graphical view]
PANTHERiPTHR19441:SF16. PTHR19441:SF16. 1 hit.
ProDomiPD288743. WFDC9_WDFC11. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein."
    Clauss A., Lilja H., Lundwall A.
    Biochem. J. 368:233-242(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.

Entry informationi

Entry nameiWFDC9_HUMAN
AccessioniPrimary (citable) accession number: Q8NEX5
Secondary accession number(s): Q3MIX6, Q5TGZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2002
Last sequence update: September 30, 2002
Last modified: February 3, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Although this protein was isolated in a region containing several WAP proteins and was defined as a WAP protein, it does not contain a classical WAP domain.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.