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Q8NEX5

- WFDC9_HUMAN

UniProt

Q8NEX5 - WFDC9_HUMAN

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Protein

Protein WFDC9

Gene
WFDC9, WAP9
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein WFDC9
Gene namesi
Name:WFDC9
Synonyms:WAP9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:20380. WFDC9.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134934414.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 8966Protein WFDC9PRO_0000041385Add
BLAST

Proteomic databases

PRIDEiQ8NEX5.

PTM databases

PhosphoSiteiQ8NEX5.

Expressioni

Gene expression databases

BgeeiQ8NEX5.
CleanExiHS_WFDC9.
GenevestigatoriQ8NEX5.

Organism-specific databases

HPAiHPA052506.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000320532.

Structurei

3D structure databases

ProteinModelPortaliQ8NEX5.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG87139.
HOGENOMiHOG000231001.
HOVERGENiHBG058740.
InParanoidiQ8NEX5.
OMAiATHINGW.
OrthoDBiEOG72RN1W.
PhylomeDBiQ8NEX5.
TreeFamiTF338513.

Family and domain databases

InterProiIPR020310. WFDC9/WFDC11.
[Graphical view]
ProDomiPD288743. WFDC9_WDFC11. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NEX5-1 [UniParc]FASTAAdd to Basket

« Hide

MKPWILLLVM FISGVVMLLP VLGSFWNKDP FLDMIRETEQ CWVQPPYKYC   50
EKRCTKIMTC VRPNHTCCWT YCGNICLDNE EPLKSMLNP 89
Length:89
Mass (Da):10,506
Last modified:October 1, 2002 - v1
Checksum:i9CC9B2013FA679EB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271N → T.
Corresponds to variant rs2245898 [ dbSNP | Ensembl ].
VAR_021911

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY047610 mRNA. Translation: AAK97772.1.
AL031671 Genomic DNA. Translation: CAI22432.1.
BC069295 mRNA. Translation: AAH69295.1.
BC101652 mRNA. Translation: AAI01653.1.
BC101656 mRNA. Translation: AAI01657.1.
CCDSiCCDS13362.1.
RefSeqiNP_671731.1. NM_147198.3.
UniGeneiHs.249828.

Genome annotation databases

EnsembliENST00000326000; ENSP00000320532; ENSG00000180205.
GeneIDi259240.
KEGGihsa:259240.
UCSCiuc002xoy.3. human.

Polymorphism databases

DMDMi26401304.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY047610 mRNA. Translation: AAK97772.1 .
AL031671 Genomic DNA. Translation: CAI22432.1 .
BC069295 mRNA. Translation: AAH69295.1 .
BC101652 mRNA. Translation: AAI01653.1 .
BC101656 mRNA. Translation: AAI01657.1 .
CCDSi CCDS13362.1.
RefSeqi NP_671731.1. NM_147198.3.
UniGenei Hs.249828.

3D structure databases

ProteinModelPortali Q8NEX5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000320532.

PTM databases

PhosphoSitei Q8NEX5.

Polymorphism databases

DMDMi 26401304.

Proteomic databases

PRIDEi Q8NEX5.

Protocols and materials databases

DNASUi 259240.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000326000 ; ENSP00000320532 ; ENSG00000180205 .
GeneIDi 259240.
KEGGi hsa:259240.
UCSCi uc002xoy.3. human.

Organism-specific databases

CTDi 259240.
GeneCardsi GC20M044236.
HGNCi HGNC:20380. WFDC9.
HPAi HPA052506.
neXtProti NX_Q8NEX5.
PharmGKBi PA134934414.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG87139.
HOGENOMi HOG000231001.
HOVERGENi HBG058740.
InParanoidi Q8NEX5.
OMAi ATHINGW.
OrthoDBi EOG72RN1W.
PhylomeDBi Q8NEX5.
TreeFami TF338513.

Miscellaneous databases

GenomeRNAii 259240.
NextBioi 93082.
PROi Q8NEX5.

Gene expression databases

Bgeei Q8NEX5.
CleanExi HS_WFDC9.
Genevestigatori Q8NEX5.

Family and domain databases

InterProi IPR020310. WFDC9/WFDC11.
[Graphical view ]
ProDomi PD288743. WFDC9_WDFC11. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein."
    Clauss A., Lilja H., Lundwall A.
    Biochem. J. 368:233-242(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.

Entry informationi

Entry nameiWFDC9_HUMAN
AccessioniPrimary (citable) accession number: Q8NEX5
Secondary accession number(s): Q3MIX6, Q5TGZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Although this protein was isolated in a region containing several WAP proteins and was defined as a WAP protein, it does not contain a classical WAP domain.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

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