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Protein

Zinc transporter 7

Gene

SLC30A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Enzyme and pathway databases

ReactomeiR-HSA-264876 Insulin processing
R-HSA-435368 Zinc efflux and compartmentalization by the SLC30 family

Protein family/group databases

TCDBi2.A.4.4.5 the cation diffusion facilitator (cdf) family

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 7
Short name:
ZnT-7
Alternative name(s):
Solute carrier family 30 member 7
Znt-like transporter 2
Gene namesi
Name:SLC30A7
Synonyms:ZNT7, ZNTL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162695.11
HGNCiHGNC:19306 SLC30A7
MIMi611149 gene
neXtProtiNX_Q8NEW0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37CytoplasmicSequence analysisAdd BLAST37
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Topological domaini59 – 67ExtracellularSequence analysis9
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Topological domaini89 – 102CytoplasmicSequence analysisAdd BLAST14
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 140ExtracellularSequence analysisAdd BLAST17
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 236CytoplasmicSequence analysisAdd BLAST75
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Topological domaini258 – 262ExtracellularSequence analysis5
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 376CytoplasmicSequence analysisAdd BLAST93

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi148867
MalaCardsiSLC30A7
OpenTargetsiENSG00000162695
PharmGKBiPA134891595

Polymorphism and mutation databases

BioMutaiSLC30A7
DMDMi74751261

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003142991 – 376Zinc transporter 7Add BLAST376

Proteomic databases

EPDiQ8NEW0
MaxQBiQ8NEW0
PaxDbiQ8NEW0
PeptideAtlasiQ8NEW0
PRIDEiQ8NEW0

PTM databases

iPTMnetiQ8NEW0
PhosphoSitePlusiQ8NEW0
SwissPalmiQ8NEW0

Expressioni

Inductioni

Increased intracellular zinc level, resulting from extracellular zinc supplementation, do not induce any up- or down-regulation of gene expression. Up-regulated by zinc depletion.1 Publication

Gene expression databases

BgeeiENSG00000162695
CleanExiHS_SLC30A7
ExpressionAtlasiQ8NEW0 baseline and differential
GenevisibleiQ8NEW0 HS

Organism-specific databases

HPAiHPA018034

Interactioni

Subunit structurei

Homooligomer.

Protein-protein interaction databases

BioGridi127176, 21 interactors
IntActiQ8NEW0, 11 interactors
MINTiQ8NEW0
STRINGi9606.ENSP00000350278

Structurei

3D structure databases

ProteinModelPortaliQ8NEW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni161 – 218His-rich loopAdd BLAST58

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1484 Eukaryota
COG1230 LUCA
GeneTreeiENSGT00630000089781
HOGENOMiHOG000018690
HOVERGENiHBG056637
InParanoidiQ8NEW0
KOiK14692
OMAiWKRLIFS
OrthoDBiEOG091G030D
PhylomeDBiQ8NEW0
TreeFamiTF315217

Family and domain databases

Gene3Di1.20.1510.10, 2 hits
InterProiView protein in InterPro
IPR002524 Cation_efflux
IPR027469 Cation_efflux_TMD_sf
PfamiView protein in Pfam
PF01545 Cation_efflux, 1 hit
SUPFAMiSSF161111 SSF161111, 2 hits
TIGRFAMsiTIGR01297 CDF, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NEW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLSIKDDE YKPPKFNLFG KISGWFRSIL SDKTSRNLFF FLCLNLSFAF
60 70 80 90 100
VELLYGIWSN CLGLISDSFH MFFDSTAILA GLAASVISKW RDNDAFSYGY
110 120 130 140 150
VRAEVLAGFV NGLFLIFTAF FIFSEGVERA LAPPDVHHER LLLVSILGFV
160 170 180 190 200
VNLIGIFVFK HGGHGHSHGS GHGHSHSLFN GALDQAHGHV DHCHSHEVKH
210 220 230 240 250
GAAHSHDHAH GHGHFHSHDG PSLKETTGPS RQILQGVFLH ILADTLGSIG
260 270 280 290 300
VIASAIMMQN FGLMIADPIC SILIAILIVV SVIPLLRESV GILMQRTPPL
310 320 330 340 350
LENSLPQCYQ RVQQLQGVYS LQEQHFWTLC SDVYVGTLKL IVAPDADARW
360 370
ILSQTHNIFT QAGVRQLYVQ IDFAAM
Length:376
Mass (Da):41,626
Last modified:October 1, 2002 - v1
Checksum:i8E4230C4B9EC5848
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91R → G in AAL83716 (Ref. 3) Curated1
Sequence conflicti318V → A in AAL83716 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529197 mRNA Translation: AAO17324.1
AY094606 mRNA Translation: AAM21969.1
AF233345 mRNA Translation: AAL83716.1
AK313638 mRNA Translation: BAG36396.1
BX537375 mRNA Translation: CAD97617.1
AC104506 Genomic DNA No translation available.
AL732465 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW72942.1
CH471097 Genomic DNA Translation: EAW72943.1
BC064692 mRNA Translation: AAH64692.1
CCDSiCCDS776.1
RefSeqiNP_001138356.1, NM_001144884.1
NP_598003.2, NM_133496.4
XP_016855889.1, XM_017000400.1
UniGeneiHs.533903

Genome annotation databases

EnsembliENST00000357650; ENSP00000350278; ENSG00000162695
ENST00000370112; ENSP00000359130; ENSG00000162695
GeneIDi148867
KEGGihsa:148867
UCSCiuc001dtn.3 human

Similar proteinsi

Entry informationi

Entry nameiZNT7_HUMAN
AccessioniPrimary (citable) accession number: Q8NEW0
Secondary accession number(s): B2R949, D3DT61, Q8TCH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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