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Protein

Zinc transporter 7

Gene

SLC30A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity).By similarity

GO - Molecular functioni

  1. cation transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. sequestering of zinc ion Source: Ensembl
  3. transmembrane transport Source: Reactome
  4. zinc II ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiREACT_15550. Insulin processing.
REACT_20582. Zinc efflux and compartmentalization by the SLC30 family.

Protein family/group databases

TCDBi2.A.4.4.5. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 7
Short name:
ZnT-7
Alternative name(s):
Solute carrier family 30 member 7
Znt-like transporter 2
Gene namesi
Name:SLC30A7
Synonyms:ZNT7, ZNTL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19306. SLC30A7.

Subcellular locationi

  1. Golgi apparatustrans-Golgi network membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei38 – 5821HelicalSequence AnalysisAdd
BLAST
Topological domaini59 – 679ExtracellularSequence Analysis
Transmembranei68 – 8821HelicalSequence AnalysisAdd
BLAST
Topological domaini89 – 10214CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Topological domaini124 – 14017ExtracellularSequence AnalysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence AnalysisAdd
BLAST
Topological domaini162 – 23675CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25721HelicalSequence AnalysisAdd
BLAST
Topological domaini258 – 2625ExtracellularSequence Analysis
Transmembranei263 – 28321HelicalSequence AnalysisAdd
BLAST
Topological domaini284 – 37693CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. cytoplasmic membrane-bounded vesicle Source: Ensembl
  3. extracellular vesicular exosome Source: UniProtKB
  4. Golgi apparatus Source: LIFEdb
  5. integral component of membrane Source: UniProtKB-KW
  6. perinuclear region of cytoplasm Source: Ensembl
  7. vesicle Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134891595.

Polymorphism and mutation databases

BioMutaiSLC30A7.
DMDMi74751261.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Zinc transporter 7PRO_0000314299Add
BLAST

Proteomic databases

MaxQBiQ8NEW0.
PaxDbiQ8NEW0.
PRIDEiQ8NEW0.

PTM databases

PhosphoSiteiQ8NEW0.

Expressioni

Inductioni

Increased intracellular zinc level, resulting from extracellular zinc supplementation, do not induce any up- or down-regulation of gene expression. Up-regulated by zinc depletion.1 Publication

Gene expression databases

BgeeiQ8NEW0.
CleanExiHS_SLC30A7.
GenevestigatoriQ8NEW0.

Organism-specific databases

HPAiHPA018034.

Interactioni

Subunit structurei

Homooligomer.

Protein-protein interaction databases

BioGridi127176. 12 interactions.
IntActiQ8NEW0. 1 interaction.
MINTiMINT-4723925.
STRINGi9606.ENSP00000350278.

Structurei

3D structure databases

ProteinModelPortaliQ8NEW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni161 – 21858His-rich loopAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1230.
GeneTreeiENSGT00630000089781.
HOGENOMiHOG000018690.
HOVERGENiHBG056637.
InParanoidiQ8NEW0.
KOiK14692.
OMAiEPPDVHH.
OrthoDBiEOG7C2R1S.
PhylomeDBiQ8NEW0.
TreeFamiTF315217.

Family and domain databases

Gene3Di1.20.1510.10. 2 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NEW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLSIKDDE YKPPKFNLFG KISGWFRSIL SDKTSRNLFF FLCLNLSFAF
60 70 80 90 100
VELLYGIWSN CLGLISDSFH MFFDSTAILA GLAASVISKW RDNDAFSYGY
110 120 130 140 150
VRAEVLAGFV NGLFLIFTAF FIFSEGVERA LAPPDVHHER LLLVSILGFV
160 170 180 190 200
VNLIGIFVFK HGGHGHSHGS GHGHSHSLFN GALDQAHGHV DHCHSHEVKH
210 220 230 240 250
GAAHSHDHAH GHGHFHSHDG PSLKETTGPS RQILQGVFLH ILADTLGSIG
260 270 280 290 300
VIASAIMMQN FGLMIADPIC SILIAILIVV SVIPLLRESV GILMQRTPPL
310 320 330 340 350
LENSLPQCYQ RVQQLQGVYS LQEQHFWTLC SDVYVGTLKL IVAPDADARW
360 370
ILSQTHNIFT QAGVRQLYVQ IDFAAM
Length:376
Mass (Da):41,626
Last modified:October 1, 2002 - v1
Checksum:i8E4230C4B9EC5848
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911R → G in AAL83716 (Ref. 3) Curated
Sequence conflicti318 – 3181V → A in AAL83716 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529197 mRNA. Translation: AAO17324.1.
AY094606 mRNA. Translation: AAM21969.1.
AF233345 mRNA. Translation: AAL83716.1.
AK313638 mRNA. Translation: BAG36396.1.
BX537375 mRNA. Translation: CAD97617.1.
AL732465, AC104506 Genomic DNA. Translation: CAI13301.1.
CH471097 Genomic DNA. Translation: EAW72942.1.
CH471097 Genomic DNA. Translation: EAW72943.1.
BC064692 mRNA. Translation: AAH64692.1.
CCDSiCCDS776.1.
RefSeqiNP_001138356.1. NM_001144884.1.
NP_598003.2. NM_133496.4.
UniGeneiHs.533903.

Genome annotation databases

EnsembliENST00000357650; ENSP00000350278; ENSG00000162695.
ENST00000370112; ENSP00000359130; ENSG00000162695.
GeneIDi148867.
KEGGihsa:148867.
UCSCiuc001dtn.2. human.

Polymorphism and mutation databases

BioMutaiSLC30A7.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529197 mRNA. Translation: AAO17324.1.
AY094606 mRNA. Translation: AAM21969.1.
AF233345 mRNA. Translation: AAL83716.1.
AK313638 mRNA. Translation: BAG36396.1.
BX537375 mRNA. Translation: CAD97617.1.
AL732465, AC104506 Genomic DNA. Translation: CAI13301.1.
CH471097 Genomic DNA. Translation: EAW72942.1.
CH471097 Genomic DNA. Translation: EAW72943.1.
BC064692 mRNA. Translation: AAH64692.1.
CCDSiCCDS776.1.
RefSeqiNP_001138356.1. NM_001144884.1.
NP_598003.2. NM_133496.4.
UniGeneiHs.533903.

3D structure databases

ProteinModelPortaliQ8NEW0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127176. 12 interactions.
IntActiQ8NEW0. 1 interaction.
MINTiMINT-4723925.
STRINGi9606.ENSP00000350278.

Protein family/group databases

TCDBi2.A.4.4.5. the cation diffusion facilitator (cdf) family.

PTM databases

PhosphoSiteiQ8NEW0.

Polymorphism and mutation databases

BioMutaiSLC30A7.
DMDMi74751261.

Proteomic databases

MaxQBiQ8NEW0.
PaxDbiQ8NEW0.
PRIDEiQ8NEW0.

Protocols and materials databases

DNASUi148867.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357650; ENSP00000350278; ENSG00000162695.
ENST00000370112; ENSP00000359130; ENSG00000162695.
GeneIDi148867.
KEGGihsa:148867.
UCSCiuc001dtn.2. human.

Organism-specific databases

CTDi148867.
GeneCardsiGC01P101361.
HGNCiHGNC:19306. SLC30A7.
HPAiHPA018034.
MIMi611149. gene.
neXtProtiNX_Q8NEW0.
PharmGKBiPA134891595.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1230.
GeneTreeiENSGT00630000089781.
HOGENOMiHOG000018690.
HOVERGENiHBG056637.
InParanoidiQ8NEW0.
KOiK14692.
OMAiEPPDVHH.
OrthoDBiEOG7C2R1S.
PhylomeDBiQ8NEW0.
TreeFamiTF315217.

Enzyme and pathway databases

ReactomeiREACT_15550. Insulin processing.
REACT_20582. Zinc efflux and compartmentalization by the SLC30 family.

Miscellaneous databases

ChiTaRSiSLC30A7. human.
GeneWikiiSLC30A7.
GenomeRNAii148867.
NextBioi86021.
PROiQ8NEW0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NEW0.
CleanExiHS_SLC30A7.
GenevestigatoriQ8NEW0.

Family and domain databases

Gene3Di1.20.1510.10. 2 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus."
    Kirschke C.P., Huang L.
    J. Biol. Chem. 278:4096-4102(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  2. "Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study."
    Devergnas S., Chimienti F., Naud N., Pennequin A., Coquerel Y., Chantegrel J., Favier A., Seve M.
    Biochem. Pharmacol. 68:699-709(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
  3. "Cloning of new mammalian zinc transporter-like genes."
    Zhu W., Mager S.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal kidney.
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  9. "Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells."
    Suzuki T., Ishihara K., Migaki H., Ishihara K., Nagao M., Yamaguchi-Iwai Y., Kambe T.
    J. Biol. Chem. 280:30956-30962(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiZNT7_HUMAN
AccessioniPrimary (citable) accession number: Q8NEW0
Secondary accession number(s): B2R949, D3DT61, Q8TCH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: April 29, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.