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Q8NEW0 (ZNT7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc transporter 7

Short name=ZnT-7
Alternative name(s):
Solute carrier family 30 member 7
Znt-like transporter 2
Gene names
Name:SLC30A7
Synonyms:ZNT7, ZNTL2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP By similarity. Ref.2 Ref.9

Subunit structure

Homooligomer.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Multi-pass membrane protein Ref.1.

Induction

Increased intracellular zinc level, resulting from extracellular zinc supplementation, do not induce any up- or down-regulation of gene expression. Up-regulated by zinc depletion. Ref.2

Sequence similarities

Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Zinc transporter 7
PRO_0000314299

Regions

Topological domain1 – 3737Cytoplasmic Potential
Transmembrane38 – 5821Helical; Potential
Topological domain59 – 679Extracellular Potential
Transmembrane68 – 8821Helical; Potential
Topological domain89 – 10214Cytoplasmic Potential
Transmembrane103 – 12321Helical; Potential
Topological domain124 – 14017Extracellular Potential
Transmembrane141 – 16121Helical; Potential
Topological domain162 – 23675Cytoplasmic Potential
Transmembrane237 – 25721Helical; Potential
Topological domain258 – 2625Extracellular Potential
Transmembrane263 – 28321Helical; Potential
Topological domain284 – 37693Cytoplasmic Potential
Region161 – 21858His-rich loop

Experimental info

Sequence conflict911R → G in AAL83716. Ref.3
Sequence conflict3181V → A in AAL83716. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8NEW0 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 8E4230C4B9EC5848

FASTA37641,626
        10         20         30         40         50         60 
MLPLSIKDDE YKPPKFNLFG KISGWFRSIL SDKTSRNLFF FLCLNLSFAF VELLYGIWSN 

        70         80         90        100        110        120 
CLGLISDSFH MFFDSTAILA GLAASVISKW RDNDAFSYGY VRAEVLAGFV NGLFLIFTAF 

       130        140        150        160        170        180 
FIFSEGVERA LAPPDVHHER LLLVSILGFV VNLIGIFVFK HGGHGHSHGS GHGHSHSLFN 

       190        200        210        220        230        240 
GALDQAHGHV DHCHSHEVKH GAAHSHDHAH GHGHFHSHDG PSLKETTGPS RQILQGVFLH 

       250        260        270        280        290        300 
ILADTLGSIG VIASAIMMQN FGLMIADPIC SILIAILIVV SVIPLLRESV GILMQRTPPL 

       310        320        330        340        350        360 
LENSLPQCYQ RVQQLQGVYS LQEQHFWTLC SDVYVGTLKL IVAPDADARW ILSQTHNIFT 

       370 
QAGVRQLYVQ IDFAAM 

« Hide

References

« Hide 'large scale' references
[1]"ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus."
Kirschke C.P., Huang L.
J. Biol. Chem. 278:4096-4102(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
[2]"Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study."
Devergnas S., Chimienti F., Naud N., Pennequin A., Coquerel Y., Chantegrel J., Favier A., Seve M.
Biochem. Pharmacol. 68:699-709(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
[3]"Cloning of new mammalian zinc transporter-like genes."
Zhu W., Mager S.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Trachea.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Fetal kidney.
[6]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[9]"Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells."
Suzuki T., Ishihara K., Migaki H., Ishihara K., Nagao M., Yamaguchi-Iwai Y., Kambe T.
J. Biol. Chem. 280:30956-30962(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF529197 mRNA. Translation: AAO17324.1.
AY094606 mRNA. Translation: AAM21969.1.
AF233345 mRNA. Translation: AAL83716.1.
AK313638 mRNA. Translation: BAG36396.1.
BX537375 mRNA. Translation: CAD97617.1.
AL732465, AC104506 Genomic DNA. Translation: CAI13301.1.
CH471097 Genomic DNA. Translation: EAW72942.1.
CH471097 Genomic DNA. Translation: EAW72943.1.
BC064692 mRNA. Translation: AAH64692.1.
RefSeqNP_001138356.1. NM_001144884.1.
NP_598003.2. NM_133496.4.
XP_005270560.1. XM_005270503.2.
UniGeneHs.533903.

3D structure databases

ProteinModelPortalQ8NEW0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127176. 4 interactions.
IntActQ8NEW0. 1 interaction.
MINTMINT-4723925.
STRING9606.ENSP00000350278.

Protein family/group databases

TCDB2.A.4.4.5. the cation diffusion facilitator (cdf) family.

PTM databases

PhosphoSiteQ8NEW0.

Polymorphism databases

DMDM74751261.

Proteomic databases

PaxDbQ8NEW0.
PRIDEQ8NEW0.

Protocols and materials databases

DNASU148867.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000357650; ENSP00000350278; ENSG00000162695.
ENST00000370112; ENSP00000359130; ENSG00000162695.
GeneID148867.
KEGGhsa:148867.
UCSCuc001dtn.2. human.

Organism-specific databases

CTD148867.
GeneCardsGC01P101361.
HGNCHGNC:19306. SLC30A7.
HPAHPA018034.
MIM611149. gene.
neXtProtNX_Q8NEW0.
PharmGKBPA134891595.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1230.
HOGENOMHOG000018690.
HOVERGENHBG056637.
InParanoidQ8NEW0.
KOK14692.
OMAFQHGGHG.
OrthoDBEOG7C2R1S.
PhylomeDBQ8NEW0.
TreeFamTF315217.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_17015. Metabolism of proteins.

Gene expression databases

BgeeQ8NEW0.
CleanExHS_SLC30A7.
GenevestigatorQ8NEW0.

Family and domain databases

Gene3D1.20.1510.10. 2 hits.
InterProIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERPTHR11562. PTHR11562. 1 hit.
PfamPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsTIGR01297. CDF. 1 hit.
ProtoNetSearch...

Other

GeneWikiSLC30A7.
GenomeRNAi148867.
NextBio86021.
PROQ8NEW0.
SOURCESearch...

Entry information

Entry nameZNT7_HUMAN
AccessionPrimary (citable) accession number: Q8NEW0
Secondary accession number(s): B2R949, D3DT61, Q8TCH2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM