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Q8NEW0

- ZNT7_HUMAN

UniProt

Q8NEW0 - ZNT7_HUMAN

Protein

Zinc transporter 7

Gene

SLC30A7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP By similarity.By similarity

    GO - Molecular functioni

    1. cation transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. sequestering of zinc ion Source: Ensembl
    3. transmembrane transport Source: Reactome
    4. zinc ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Enzyme and pathway databases

    ReactomeiREACT_15550. Insulin processing.
    REACT_20582. Zinc efflux and compartmentalization by the SLC30 family.

    Protein family/group databases

    TCDBi2.A.4.4.5. the cation diffusion facilitator (cdf) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter 7
    Short name:
    ZnT-7
    Alternative name(s):
    Solute carrier family 30 member 7
    Znt-like transporter 2
    Gene namesi
    Name:SLC30A7
    Synonyms:ZNT7, ZNTL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:19306. SLC30A7.

    Subcellular locationi

    Golgi apparatustrans-Golgi network membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. cytoplasmic membrane-bounded vesicle Source: Ensembl
    3. extracellular vesicular exosome Source: UniProt
    4. Golgi apparatus Source: BHF-UCL
    5. Golgi membrane Source: Reactome
    6. integral component of membrane Source: UniProtKB-KW
    7. perinuclear region of cytoplasm Source: Ensembl
    8. vesicle Source: BHF-UCL

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134891595.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Zinc transporter 7PRO_0000314299Add
    BLAST

    Proteomic databases

    MaxQBiQ8NEW0.
    PaxDbiQ8NEW0.
    PRIDEiQ8NEW0.

    PTM databases

    PhosphoSiteiQ8NEW0.

    Expressioni

    Inductioni

    Increased intracellular zinc level, resulting from extracellular zinc supplementation, do not induce any up- or down-regulation of gene expression. Up-regulated by zinc depletion.1 Publication

    Gene expression databases

    BgeeiQ8NEW0.
    CleanExiHS_SLC30A7.
    GenevestigatoriQ8NEW0.

    Organism-specific databases

    HPAiHPA018034.

    Interactioni

    Subunit structurei

    Homooligomer.

    Protein-protein interaction databases

    BioGridi127176. 6 interactions.
    IntActiQ8NEW0. 1 interaction.
    MINTiMINT-4723925.
    STRINGi9606.ENSP00000350278.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NEW0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3737CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini59 – 679ExtracellularSequence Analysis
    Topological domaini89 – 10214CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini124 – 14017ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini162 – 23675CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 2625ExtracellularSequence Analysis
    Topological domaini284 – 37693CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei68 – 8821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni161 – 21858His-rich loopAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1230.
    HOGENOMiHOG000018690.
    HOVERGENiHBG056637.
    InParanoidiQ8NEW0.
    KOiK14692.
    OMAiCSILIAM.
    OrthoDBiEOG7C2R1S.
    PhylomeDBiQ8NEW0.
    TreeFamiTF315217.

    Family and domain databases

    Gene3Di1.20.1510.10. 2 hits.
    InterProiIPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    [Graphical view]
    PANTHERiPTHR11562. PTHR11562. 1 hit.
    PfamiPF01545. Cation_efflux. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01297. CDF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8NEW0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPLSIKDDE YKPPKFNLFG KISGWFRSIL SDKTSRNLFF FLCLNLSFAF    50
    VELLYGIWSN CLGLISDSFH MFFDSTAILA GLAASVISKW RDNDAFSYGY 100
    VRAEVLAGFV NGLFLIFTAF FIFSEGVERA LAPPDVHHER LLLVSILGFV 150
    VNLIGIFVFK HGGHGHSHGS GHGHSHSLFN GALDQAHGHV DHCHSHEVKH 200
    GAAHSHDHAH GHGHFHSHDG PSLKETTGPS RQILQGVFLH ILADTLGSIG 250
    VIASAIMMQN FGLMIADPIC SILIAILIVV SVIPLLRESV GILMQRTPPL 300
    LENSLPQCYQ RVQQLQGVYS LQEQHFWTLC SDVYVGTLKL IVAPDADARW 350
    ILSQTHNIFT QAGVRQLYVQ IDFAAM 376
    Length:376
    Mass (Da):41,626
    Last modified:October 1, 2002 - v1
    Checksum:i8E4230C4B9EC5848
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti91 – 911R → G in AAL83716. 1 PublicationCurated
    Sequence conflicti318 – 3181V → A in AAL83716. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF529197 mRNA. Translation: AAO17324.1.
    AY094606 mRNA. Translation: AAM21969.1.
    AF233345 mRNA. Translation: AAL83716.1.
    AK313638 mRNA. Translation: BAG36396.1.
    BX537375 mRNA. Translation: CAD97617.1.
    AL732465, AC104506 Genomic DNA. Translation: CAI13301.1.
    CH471097 Genomic DNA. Translation: EAW72942.1.
    CH471097 Genomic DNA. Translation: EAW72943.1.
    BC064692 mRNA. Translation: AAH64692.1.
    CCDSiCCDS776.1.
    RefSeqiNP_001138356.1. NM_001144884.1.
    NP_598003.2. NM_133496.4.
    XP_005270560.1. XM_005270503.2.
    UniGeneiHs.533903.

    Genome annotation databases

    EnsembliENST00000357650; ENSP00000350278; ENSG00000162695.
    ENST00000370112; ENSP00000359130; ENSG00000162695.
    GeneIDi148867.
    KEGGihsa:148867.
    UCSCiuc001dtn.2. human.

    Polymorphism databases

    DMDMi74751261.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF529197 mRNA. Translation: AAO17324.1 .
    AY094606 mRNA. Translation: AAM21969.1 .
    AF233345 mRNA. Translation: AAL83716.1 .
    AK313638 mRNA. Translation: BAG36396.1 .
    BX537375 mRNA. Translation: CAD97617.1 .
    AL732465 , AC104506 Genomic DNA. Translation: CAI13301.1 .
    CH471097 Genomic DNA. Translation: EAW72942.1 .
    CH471097 Genomic DNA. Translation: EAW72943.1 .
    BC064692 mRNA. Translation: AAH64692.1 .
    CCDSi CCDS776.1.
    RefSeqi NP_001138356.1. NM_001144884.1.
    NP_598003.2. NM_133496.4.
    XP_005270560.1. XM_005270503.2.
    UniGenei Hs.533903.

    3D structure databases

    ProteinModelPortali Q8NEW0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127176. 6 interactions.
    IntActi Q8NEW0. 1 interaction.
    MINTi MINT-4723925.
    STRINGi 9606.ENSP00000350278.

    Protein family/group databases

    TCDBi 2.A.4.4.5. the cation diffusion facilitator (cdf) family.

    PTM databases

    PhosphoSitei Q8NEW0.

    Polymorphism databases

    DMDMi 74751261.

    Proteomic databases

    MaxQBi Q8NEW0.
    PaxDbi Q8NEW0.
    PRIDEi Q8NEW0.

    Protocols and materials databases

    DNASUi 148867.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357650 ; ENSP00000350278 ; ENSG00000162695 .
    ENST00000370112 ; ENSP00000359130 ; ENSG00000162695 .
    GeneIDi 148867.
    KEGGi hsa:148867.
    UCSCi uc001dtn.2. human.

    Organism-specific databases

    CTDi 148867.
    GeneCardsi GC01P101361.
    HGNCi HGNC:19306. SLC30A7.
    HPAi HPA018034.
    MIMi 611149. gene.
    neXtProti NX_Q8NEW0.
    PharmGKBi PA134891595.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1230.
    HOGENOMi HOG000018690.
    HOVERGENi HBG056637.
    InParanoidi Q8NEW0.
    KOi K14692.
    OMAi CSILIAM.
    OrthoDBi EOG7C2R1S.
    PhylomeDBi Q8NEW0.
    TreeFami TF315217.

    Enzyme and pathway databases

    Reactomei REACT_15550. Insulin processing.
    REACT_20582. Zinc efflux and compartmentalization by the SLC30 family.

    Miscellaneous databases

    GeneWikii SLC30A7.
    GenomeRNAii 148867.
    NextBioi 86021.
    PROi Q8NEW0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8NEW0.
    CleanExi HS_SLC30A7.
    Genevestigatori Q8NEW0.

    Family and domain databases

    Gene3Di 1.20.1510.10. 2 hits.
    InterProi IPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    [Graphical view ]
    PANTHERi PTHR11562. PTHR11562. 1 hit.
    Pfami PF01545. Cation_efflux. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01297. CDF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus."
      Kirschke C.P., Huang L.
      J. Biol. Chem. 278:4096-4102(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    2. "Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study."
      Devergnas S., Chimienti F., Naud N., Pennequin A., Coquerel Y., Chantegrel J., Favier A., Seve M.
      Biochem. Pharmacol. 68:699-709(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
    3. "Cloning of new mammalian zinc transporter-like genes."
      Zhu W., Mager S.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Trachea.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal kidney.
    6. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    9. "Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells."
      Suzuki T., Ishihara K., Migaki H., Ishihara K., Nagao M., Yamaguchi-Iwai Y., Kambe T.
      J. Biol. Chem. 280:30956-30962(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiZNT7_HUMAN
    AccessioniPrimary (citable) accession number: Q8NEW0
    Secondary accession number(s): B2R949, D3DT61, Q8TCH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3