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Protein

Casein kinase II subunit alpha 3

Gene

CSNK2A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei68 – 681ATPPROSITE-ProRule annotation
Active sitei156 – 1561Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi45 – 539ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • positive regulation of cell growth Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of protein catabolic process Source: UniProtKB
  • protein autophosphorylation Source: Ensembl
  • protein phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8NEV1.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase II subunit alpha 3 (EC:2.7.11.1)
Short name:
CK II alpha 3
Alternative name(s):
Casein kinase II alpha 1 polypeptide pseudogene
Gene namesi
Name:CSNK2A3
Synonyms:CSNK2A1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:2458. CSNK2A3.

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Polymorphism and mutation databases

BioMutaiCSNK2A3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Casein kinase II subunit alpha 3PRO_0000422194Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei344 – 3441PhosphothreonineBy similarity
Modified residuei360 – 3601PhosphothreonineBy similarity
Modified residuei362 – 3621PhosphoserineBy similarity
Modified residuei370 – 3701PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8NEV1.
PaxDbiQ8NEV1.
PeptideAtlasiQ8NEV1.
PRIDEiQ8NEV1.

PTM databases

iPTMnetiQ8NEV1.
PhosphoSiteiQ8NEV1.

Expressioni

Tissue specificityi

Detected in blood platelets and megakaryocyte cell lines. Poorly expressed in lung. Highly expressed in lung tumor tissues.2 Publications

Gene expression databases

BgeeiENSG00000254598.
GenevisibleiQ8NEV1. HS.

Organism-specific databases

HPAiCAB000048.
CAB012098.
CAB053843.

Interactioni

Subunit structurei

Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha' chain) and two regulatory subunits (beta chains) (By similarity). Interacts with PML.By similarity1 Publication

Protein-protein interaction databases

BioGridi129460. 1 interaction.
STRINGi9606.ENSP00000217244.

Structurei

3D structure databases

ProteinModelPortaliQ8NEV1.
SMRiQ8NEV1. Positions 2-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 324286Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0668. Eukaryota.
ENOG410XNPP. LUCA.
GeneTreeiENSGT00390000004215.
HOVERGENiHBG107282.
InParanoidiQ8NEV1.
KOiK03097.
OMAiECQIKRE.
OrthoDBiEOG091G0AZY.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NEV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGPVPSRAR VYTDVNTHRP REYWDYESHV VEWGNQDDYQ LVRKLGRGKY
60 70 80 90 100
SEVFEAINIT NNEKVVVKIL KPVKKKKIKR EIKILENLRG GPNIITLADI
110 120 130 140 150
VKDPVSRTPA LVFEHVNNTD FKQLYQTLTD YDIRFYMYEI LKALDYCHSM
160 170 180 190 200
GIMHRDVKPH NVMIDHEHRK LRLIDWGLAE FYHPGQEYNV RVASRYFKGP
210 220 230 240 250
ELLVDYQMYD YSLDMWRLGC MLASMIFRKE PFFHGRDNYD QLVRIAKFLG
260 270 280 290 300
TEDLYGYIDK YNIELDPRFN DILGRHSRKR WERFVHSENQ HLVSPEALDF
310 320 330 340 350
LDKLLRYDHQ SRLTAREAME HPYFYTVVKD QARMGSSSMP GGSTPVSSAN
360 370 380 390
VMSGISSVPT PSPLGPLAGS PVIAAANPLG MPVPAATGAQ Q
Length:391
Mass (Da):45,220
Last modified:May 1, 2013 - v2
Checksum:iD0FA2E3EACB5A064
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281L → F in X64692 (PubMed:1610905).Curated
Sequence conflicti128 – 1281L → F in AAM52224 (PubMed:12102635).Curated
Sequence conflicti128 – 1281L → F in EAW68546 (Ref. 5) Curated
Sequence conflicti217 – 2171R → S in X64692 (PubMed:1610905).Curated
Sequence conflicti217 – 2171R → S in AAM52224 (PubMed:12102635).Curated
Sequence conflicti217 – 2171R → S in EAW68546 (Ref. 5) Curated
Sequence conflicti236 – 2361R → H in X64692 (PubMed:1610905).Curated
Sequence conflicti248 – 2481F → V in X64692 (PubMed:1610905).Curated
Sequence conflicti248 – 2481F → V in AAM52224 (PubMed:12102635).Curated
Sequence conflicti248 – 2481F → V in EAW68546 (Ref. 5) Curated
Sequence conflicti287 – 2871S → R in X64692 (PubMed:1610905).Curated
Sequence conflicti287 – 2871S → R in AAM52224 (PubMed:12102635).Curated
Sequence conflicti287 – 2871S → R in EAW68546 (Ref. 5) Curated
Sequence conflicti296 – 2961Missing in X64692 (PubMed:1610905).Curated
Sequence conflicti387 – 3871T → A in X64692 (PubMed:1610905).Curated
Sequence conflicti387 – 3871T → A in AAM52224 (PubMed:12102635).Curated
Sequence conflicti387 – 3871T → A in EAW68546 (Ref. 5) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti133 – 1331I → T in a lung carcinoma sample; somatic mutation; shows greater kinase activity, provides a cell growth advantage and increases its interaction with the PML tumor suppressor protein and PML degradation. 1 Publication
Corresponds to variant rs2071460 [ dbSNP | Ensembl ].
VAR_069225

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64692 Genomic DNA. No translation available.
AY112721 mRNA. Translation: AAM52224.1.
CH471064 Genomic DNA. Translation: EAW68546.1.
RefSeqiNP_001243615.1. NM_001256686.1.
UniGeneiHs.644056.
Hs.654675.
Hs.741126.

Genome annotation databases

EnsembliENST00000528848; ENSP00000473553; ENSG00000254598.
GeneIDi283106.
KEGGihsa:283106.
UCSCiuc001mjp.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64692 Genomic DNA. No translation available.
AY112721 mRNA. Translation: AAM52224.1.
CH471064 Genomic DNA. Translation: EAW68546.1.
RefSeqiNP_001243615.1. NM_001256686.1.
UniGeneiHs.644056.
Hs.654675.
Hs.741126.

3D structure databases

ProteinModelPortaliQ8NEV1.
SMRiQ8NEV1. Positions 2-359.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129460. 1 interaction.
STRINGi9606.ENSP00000217244.

PTM databases

iPTMnetiQ8NEV1.
PhosphoSiteiQ8NEV1.

Polymorphism and mutation databases

BioMutaiCSNK2A3.

Proteomic databases

EPDiQ8NEV1.
PaxDbiQ8NEV1.
PeptideAtlasiQ8NEV1.
PRIDEiQ8NEV1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000528848; ENSP00000473553; ENSG00000254598.
GeneIDi283106.
KEGGihsa:283106.
UCSCiuc001mjp.4. human.

Organism-specific databases

CTDi283106.
GeneCardsiCSNK2A3.
H-InvDBHIX0035927.
HGNCiHGNC:2458. CSNK2A3.
HPAiCAB000048.
CAB012098.
CAB053843.
neXtProtiNX_Q8NEV1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0668. Eukaryota.
ENOG410XNPP. LUCA.
GeneTreeiENSGT00390000004215.
HOVERGENiHBG107282.
InParanoidiQ8NEV1.
KOiK03097.
OMAiECQIKRE.
OrthoDBiEOG091G0AZY.

Enzyme and pathway databases

SignaLinkiQ8NEV1.

Miscellaneous databases

GenomeRNAii283106.
PROiQ8NEV1.

Gene expression databases

BgeeiENSG00000254598.
GenevisibleiQ8NEV1. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSK23_HUMAN
AccessioniPrimary (citable) accession number: Q8NEV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: May 1, 2013
Last modified: September 7, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.