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Protein

Retrotransposon gag domain-containing protein 1

Gene

RGAG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Retrotransposon gag domain-containing protein 1
Alternative name(s):
Tumor antigen BJ-HCC-23
Gene namesi
Name:RGAG1
Synonyms:KIAA1318
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:29245. RGAG1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134934891.

Polymorphism and mutation databases

BioMutaiRGAG1.
DMDMi74715429.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13881388Retrotransposon gag domain-containing protein 1PRO_0000259627Add
BLAST

Proteomic databases

PaxDbiQ8NET4.
PRIDEiQ8NET4.

PTM databases

iPTMnetiQ8NET4.
PhosphoSiteiQ8NET4.

Expressioni

Gene expression databases

BgeeiENSG00000243978.
CleanExiHS_RGAG1.
ExpressionAtlasiQ8NET4. baseline and differential.
GenevisibleiQ8NET4. HS.

Organism-specific databases

HPAiHPA001242.

Interactioni

Protein-protein interaction databases

BioGridi121588. 5 interactions.
IntActiQ8NET4. 3 interactions.
STRINGi9606.ENSP00000419786.

Structurei

3D structure databases

ProteinModelPortaliQ8NET4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IRCF. Eukaryota.
ENOG410ZEBE. LUCA.
GeneTreeiENSGT00730000111416.
HOGENOMiHOG000231451.
HOVERGENiHBG080283.
InParanoidiQ8NET4.
OMAiTACKRNN.
OrthoDBiEOG091G02TH.
PhylomeDBiQ8NET4.
TreeFamiTF334822.

Sequencei

Sequence statusi: Complete.

Q8NET4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIPLHSLRF NNTMREENVE PQNKQMAFCR PMTETRADVQ ILHSHVQLPI
60 70 80 90 100
VSTSASDPGG TSTQLMTSPV FDTMSAPLMG VPNSGALSPP LMPASDSGAL
110 120 130 140 150
SPLLMPASDS GALSPLLMPA LDSGTLSPLL STSEYGVMSP GMMTIPDFGT
160 170 180 190 200
MSATLMVAPD SAEISPLAMP APSSGVVCTP IMSTSSSEAM STPLMLAPDS
210 220 230 240 250
GELSPILMQD MNPGVMSTQP VPAPSSEAMS PLQITDEDTE AMSKVLMTAL
260 270 280 290 300
ASGEISSLLM SGTDSEAISS LIMSAVASGG TSPQPTSTQN SGGIPTPLMS
310 320 330 340 350
DLDSGIMSSL LMSSPGSEVM STPLLSVPDA GEMSTLPKPA PDAEAMSPAL
360 370 380 390 400
MTALPSGVMP TQTMPAPGSG AMSPWSTQNV DSEMMSNPPV RATASGVMSA
410 420 430 440 450
PPVRALDSGA MSTPLMGAPA SGNMSTLQKT VPASGAMTTS LMTVPSSGVM
460 470 480 490 500
STEQMSATAS RVMSAQLTMA KTSGAMPTGS MKAVAKQYKR ATASGKMSTP
510 520 530 540 550
LRRAPTSGAM STQPVTATAS ETMSMPQLTV PASGSMSMLQ MRAPVSEAMS
560 570 580 590 600
MPQMRTMASG LTSAAQMKAM TSGAMSTPLM TAQTSGSTST LLMRDTASGV
610 620 630 640 650
MSCPQMRSLA SGALSKPLMT PKASGTMFTE KMTTTASEAM PTLLMRDTVS
660 670 680 690 700
GALSMPQMTD TASGGLSASL MRDTASGAMS TSQMTATVSG GMSMPLMRAQ
710 720 730 740 750
DPGVMPASLM RAKVSGKMLS QPMSTQDPGG MSMSPMKSMT AGGMQMNSPT
760 770 780 790 800
SDVMSTPTVR AWTSETMSTP LMRTSDPGER PSLLTRASSS GEMSLPLMRA
810 820 830 840 850
PASGEIATPL RSPAYGAMSA PQMTATASGM MSSMPQVKAP ISGAMSMPLT
860 870 880 890 900
RSTASGGMSM PLMRAPDSRV TSTSQMMPTA SGDMCTLPVR APASGGVSSP
910 920 930 940 950
LVRAPASGTM STPLRRPSAC ETVSTELMRA SASGHMSTAQ TTAMVSGGMS
960 970 980 990 1000
KPLMRAPASG TMPMPLMSAM ASGEMSMPLM ETMASGATST LQTSVANSRS
1010 1020 1030 1040 1050
MSLSQTTYTV SGRMATAPIR ASASGARSTS FMRASVSGSM PMPLPRATAS
1060 1070 1080 1090 1100
GCGMGMSMPQ MTATDSRGMS TPLMRASGPG TMSTPQTAFG VMSTPEIKAT
1110 1120 1130 1140 1150
DSGEASTSHI NITASGSKPT SHMTATTPET AKPPPKEVPS FGMLTPALCY
1160 1170 1180 1190 1200
LLEEQEAARG SCSVEEEMEI DEEKQMKGFL DDSERMAFLV SLHLGAAERW
1210 1220 1230 1240 1250
FILQMEVGEP LSHENKSFLR RSQGIYDSLS EIDILSAVLC HPKQGQKSVR
1260 1270 1280 1290 1300
QYATDFLLLA RHLSWSDAIL RTRFLEGLSE AVTTKMGRIF LKVAGSLKEL
1310 1320 1330 1340 1350
IDRSLYTECQ LAEEKDSPGN SSQVLPTACK RNNEEAMGNE LSSQQQTEEH
1360 1370 1380
QHVSKRCYYL KEHGDPQEGL HDHLGQSTGH HQKAHTNK
Length:1,388
Mass (Da):144,280
Last modified:October 1, 2002 - v1
Checksum:i19A18E68DC8C5A06
GO

Sequence cautioni

The sequence BAA92556 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti777 – 7771P → S.
Corresponds to variant rs35495390 [ dbSNP | Ensembl ].
VAR_051318

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY121804 mRNA. Translation: AAM82752.1.
AB037739 mRNA. Translation: BAA92556.1. Different initiation.
BC113670 mRNA. Translation: AAI13671.1.
BC117184 mRNA. Translation: AAI17185.1.
CCDSiCCDS14552.1.
RefSeqiNP_065820.1. NM_020769.2.
XP_011529300.1. XM_011530998.2.
XP_011529301.1. XM_011530999.2.
UniGeneiHs.201071.

Genome annotation databases

EnsembliENST00000465301; ENSP00000419786; ENSG00000243978.
ENST00000540313; ENSP00000441452; ENSG00000243978.
GeneIDi57529.
KEGGihsa:57529.
UCSCiuc004eor.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY121804 mRNA. Translation: AAM82752.1.
AB037739 mRNA. Translation: BAA92556.1. Different initiation.
BC113670 mRNA. Translation: AAI13671.1.
BC117184 mRNA. Translation: AAI17185.1.
CCDSiCCDS14552.1.
RefSeqiNP_065820.1. NM_020769.2.
XP_011529300.1. XM_011530998.2.
XP_011529301.1. XM_011530999.2.
UniGeneiHs.201071.

3D structure databases

ProteinModelPortaliQ8NET4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121588. 5 interactions.
IntActiQ8NET4. 3 interactions.
STRINGi9606.ENSP00000419786.

PTM databases

iPTMnetiQ8NET4.
PhosphoSiteiQ8NET4.

Polymorphism and mutation databases

BioMutaiRGAG1.
DMDMi74715429.

Proteomic databases

PaxDbiQ8NET4.
PRIDEiQ8NET4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000465301; ENSP00000419786; ENSG00000243978.
ENST00000540313; ENSP00000441452; ENSG00000243978.
GeneIDi57529.
KEGGihsa:57529.
UCSCiuc004eor.2. human.

Organism-specific databases

CTDi57529.
GeneCardsiRGAG1.
HGNCiHGNC:29245. RGAG1.
HPAiHPA001242.
neXtProtiNX_Q8NET4.
PharmGKBiPA134934891.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRCF. Eukaryota.
ENOG410ZEBE. LUCA.
GeneTreeiENSGT00730000111416.
HOGENOMiHOG000231451.
HOVERGENiHBG080283.
InParanoidiQ8NET4.
OMAiTACKRNN.
OrthoDBiEOG091G02TH.
PhylomeDBiQ8NET4.
TreeFamiTF334822.

Miscellaneous databases

GenomeRNAii57529.
PROiQ8NET4.

Gene expression databases

BgeeiENSG00000243978.
CleanExiHS_RGAG1.
ExpressionAtlasiQ8NET4. baseline and differential.
GenevisibleiQ8NET4. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiRGAG1_HUMAN
AccessioniPrimary (citable) accession number: Q8NET4
Secondary accession number(s): Q9P2M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.