ID   D108B_HUMAN             Reviewed;          73 AA.
AC   Q8NET1;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   26-SEP-2003, sequence version 3.
DT   13-NOV-2013, entry version 84.
DE   RecName: Full=Beta-defensin 108B;
DE   AltName: Full=Beta-defensin 8;
DE            Short=BD-8;
DE            Short=DEFB-8;
DE            Short=hBD-8;
DE   AltName: Full=Defensin, beta 108;
DE   AltName: Full=Defensin, beta 108B;
DE   Flags: Precursor;
GN   Name=DEFB108B; Synonyms=DEFB108, DEFB8;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=12600824; DOI=10.1165/rcmb.2002-0205OC;
RA   Kao C.Y., Chen Y., Zhao Y.H., Wu R.;
RT   "ORFeome-based search of airway epithelial cell-specific novel human
RT   beta-defensin genes.";
RL   Am. J. Respir. Cell Mol. Biol. 29:71-80(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 22-73, AND IDENTIFICATION.
RC   TISSUE=Testis;
RX   PubMed=11854508; DOI=10.1073/pnas.042692699;
RA   Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P.,
RA   Welsh M.J., Casavant T.L., McCray P.B. Jr.;
RT   "Discovery of five conserved beta-defensin gene clusters using a
RT   computational search strategy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-59, AND VARIANT ARG-53.
RX   PubMed=12734011; DOI=10.1186/gb-2003-4-5-r31;
RA   Semple C.A.M., Rolfe M., Dorin J.R.;
RT   "Duplication and selection in the evolution of primate beta-defensin
RT   genes.";
RL   Genome Biol. 4:R31.1-R31.11(2003).
CC   -!- FUNCTION: Has antibacterial activity (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in testis. Low
CC       expression is detected also in liver.
CC   -!- SIMILARITY: Belongs to the beta-defensin family.
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DR   EMBL; AF529416; AAQ09525.1; -; mRNA.
DR   EMBL; AY122468; AAM93910.1; -; mRNA.
DR   EMBL; AF540980; AAN33116.1; -; mRNA.
DR   IPI; IPI00172575; -.
DR   RefSeq; NP_001002035.1; NM_001002035.1.
DR   UniGene; Hs.555032; -.
DR   UniGene; Hs.583890; -.
DR   ProteinModelPortal; Q8NET1; -.
DR   STRING; 9606.ENSP00000333234; -.
DR   DMDM; 37154739; -.
DR   PaxDb; Q8NET1; -.
DR   PRIDE; Q8NET1; -.
DR   DNASU; 245911; -.
DR   Ensembl; ENST00000328698; ENSP00000333234; ENSG00000184276.
DR   GeneID; 245911; -.
DR   KEGG; hsa:245911; -.
DR   UCSC; uc010rqr.2; human.
DR   CTD; 245911; -.
DR   GeneCards; GC11P071545; -.
DR   HGNC; HGNC:29966; DEFB108B.
DR   HPA; HPA042588; -.
DR   neXtProt; NX_Q8NET1; -.
DR   PharmGKB; PA142671994; -.
DR   eggNOG; NOG87878; -.
DR   HOGENOM; HOG000112137; -.
DR   HOVERGEN; HBG081400; -.
DR   InParanoid; Q8NET1; -.
DR   OMA; CIETEIH; -.
DR   OrthoDB; EOG74BJVR; -.
DR   PhylomeDB; Q8NET1; -.
DR   Reactome; REACT_6900; Immune System.
DR   GenomeRNAi; 245911; -.
DR   NextBio; 91757; -.
DR   PRO; PR:Q8NET1; -.
DR   Bgee; Q8NET1; -.
DR   CleanEx; HS_DEFB108B; -.
DR   Genevestigator; Q8NET1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Complete proteome; Defensin;
KW   Disulfide bond; Polymorphism; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     22       Potential.
FT   PEPTIDE      23     73       Beta-defensin 108B.
FT                                /FTId=PRO_0000006981.
FT   DISULFID     28     55       By similarity.
FT   DISULFID     35     49       By similarity.
FT   DISULFID     39     56       By similarity.
FT   VARIANT      27     27       I -> V (in dbSNP:rs12285436).
FT                                /FTId=VAR_059246.
FT   VARIANT      36     36       R -> W (in dbSNP:rs12793731).
FT                                /FTId=VAR_048862.
FT   VARIANT      45     45       H -> L (in dbSNP:rs12285495).
FT                                /FTId=VAR_059247.
FT   VARIANT      53     53       Q -> R (in dbSNP:rs7120658).
FT                                /FTId=VAR_059248.
FT   CONFLICT      7      9       LFA -> FFT (in Ref. 3; AAN33116).
FT   CONFLICT     21     21       R -> K (in Ref. 3; AAN33116).
SQ   SEQUENCE   73 AA;  8326 MW;  6820F297B7C2B7F2 CRC64;
     MRIAVLLFAI FFFMSQVLPA RGKFKEICER PNGSCRDFCL ETEIHVGRCL NSQPCCLPLG
     HQPRIESTTP KKD
//