ID   D108_HUMAN     STANDARD;      PRT;    73 AA.
AC   Q8NET1;
DT   28-FEB-2003 (Rel. 41, Created)
DT   15-SEP-2003 (Rel. 42, Last sequence update)
DT   15-SEP-2003 (Rel. 42, Last annotation update)
DE   Beta-defensin 108 precursor (Beta-defensin 8) (DEFB-8).
GN   DEFB108 OR DEFB8.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A., AND TISSUE DISTRIBUTION.
RX   MEDLINE=22705149; PubMed=12600824;
RA   Kao C.Y., Chen Y., Zhao Y.H., Wu R.;
RT   "ORFeome-based search of airway epithelial cell-specific novel human
RT   beta-defensin genes.";
RL   Am. J. Respir. Cell Mol. Biol. 29:71-80(2003).
RN   [2]
RP   SEQUENCE OF 22-73 FROM N.A., AND IDENTIFICATION.
RC   TISSUE=Testis;
RX   MEDLINE=21843921; PubMed=11854508;
RA   Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P.,
RA   Welsh M.J., Casavant T.L., McCray P.B. Jr.;
RT   "Discovery of five conserved beta-defensin gene clusters using a
RT   computational search strategy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002).
RN   [3]
RP   SEQUENCE OF 1-59 FROM N.A.
RX   MEDLINE=22619651; PubMed=12734011;
RA   Semple C.A.M., Rolfe M., Dorin J.R.;
RT   "Duplication and selection in the evolution of primate beta-defensin
RT   genes.";
RL   Genome Biol. 4:RESEARCH0031.1-RESEARCH0031.11(2003).
CC   -!- FUNCTION: Has antibacterial activity (Potential).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in testis. Low
CC       expression is detected also in liver.
CC   -!- SIMILARITY: Belongs to the beta-defensin family.
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DR   EMBL; AF529416; AAQ09525.1; -.
DR   EMBL; AY122468; AAM93910.1; -.
DR   EMBL; AF540980; AAN33116.1; -.
DR   Genew; HGNC:18089; DEFB108.
KW   Antibiotic; Signal.
FT   SIGNAL        1     22       POTENTIAL.
FT   CHAIN        23     73       BETA-DEFENSIN 108.
FT   DISULFID     28     55       BY SIMILARITY.
FT   DISULFID     35     49       BY SIMILARITY.
FT   DISULFID     39     56       BY SIMILARITY.
FT   CONFLICT      7      9       LFA -> FFT (IN REF. 3).
FT   CONFLICT     21     21       R -> K (IN REF. 3).
FT   CONFLICT     53     53       Q -> R (IN REF. 3).
SQ   SEQUENCE   73 AA;  8326 MW;  6820F297B7C2B7F2 CRC64;
     MRIAVLLFAI FFFMSQVLPA RGKFKEICER PNGSCRDFCL ETEIHVGRCL NSQPCCLPLG
     HQPRIESTTP KKD
//