ID   D108B_HUMAN             Reviewed;          73 AA.
AC   Q8NET1;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   26-SEP-2003, sequence version 3.
DT   02-OCT-2007, entry version 36.
DE   Beta-defensin 108B precursor (Defensin, beta 108B) (Defensin, beta
DE   108) (Beta-defensin 8) (DEFB-8) (BD-8) (hBD-8).
GN   Name=DEFB108B; Synonyms=DEFB108, DEFB8;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   MEDLINE=22705149; PubMed=12600824; DOI=10.1165/rcmb.2002-0205OC;
RA   Kao C.Y., Chen Y., Zhao Y.H., Wu R.;
RT   "ORFeome-based search of airway epithelial cell-specific novel human
RT   beta-defensin genes.";
RL   Am. J. Respir. Cell Mol. Biol. 29:71-80(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 22-73, AND IDENTIFICATION.
RC   TISSUE=Testis;
RX   MEDLINE=21843921; PubMed=11854508; DOI=10.1073/pnas.042692699;
RA   Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P.,
RA   Welsh M.J., Casavant T.L., McCray P.B. Jr.;
RT   "Discovery of five conserved beta-defensin gene clusters using a
RT   computational search strategy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-59.
RX   MEDLINE=22619651; PubMed=12734011; DOI=10.1186/gb-2003-4-5-r31;
RA   Semple C.A.M., Rolfe M., Dorin J.R.;
RT   "Duplication and selection in the evolution of primate beta-defensin
RT   genes.";
RL   Genome Biol. 4:RESEARCH0031.1-RESEARCH0031.11(2003).
CC   -!- FUNCTION: Has antibacterial activity (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in testis. Low
CC       expression is detected also in liver.
CC   -!- SIMILARITY: Belongs to the beta-defensin family.
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DR   EMBL; AF529416; AAQ09525.1; -; mRNA.
DR   EMBL; AY122468; AAM93910.1; -; mRNA.
DR   EMBL; AF540980; AAN33116.1; -; mRNA.
DR   RefSeq; NP_001002035.1; -.
DR   UniGene; Hs.555032; -.
DR   Ensembl; ENSG00000184276; Homo sapiens.
DR   GeneID; 245911; -.
DR   HGNC; HGNC:29966; DEFB108B.
DR   PharmGKB; PA142671994; -.
DR   LinkHub; Q8NET1; -.
DR   GermOnline; ENSG00000184276; Homo sapiens.
DR   InterPro; IPR001855; Defensin_beta.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Defensin; Secreted; Signal.
FT   SIGNAL        1     22       Potential.
FT   PEPTIDE      23     73       Beta-defensin 108B.
FT                                /FTId=PRO_0000006981.
FT   DISULFID     28     55       By similarity.
FT   DISULFID     35     49       By similarity.
FT   DISULFID     39     56       By similarity.
FT   CONFLICT      7      9       LFA -> FFT (in Ref. 3).
FT   CONFLICT     21     21       R -> K (in Ref. 3).
FT   CONFLICT     53     53       Q -> R (in Ref. 3).
SQ   SEQUENCE   73 AA;  8326 MW;  6820F297B7C2B7F2 CRC64;
     MRIAVLLFAI FFFMSQVLPA RGKFKEICER PNGSCRDFCL ETEIHVGRCL NSQPCCLPLG
     HQPRIESTTP KKD
//