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Protein

Beta-defensin 108B

Gene

DEFB108B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has antibacterial activity.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

BioCyciZFISH:G66-33536-MONOMER.
ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 108B
Alternative name(s):
Beta-defensin 8
Short name:
BD-8
Short name:
DEFB-8
Short name:
hBD-8
Defensin, beta 108
Defensin, beta 108B
Gene namesi
Name:DEFB108B
Synonyms:DEFB108, DEFB8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:29966. DEFB108B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi245911.
OpenTargetsiENSG00000184276.
PharmGKBiPA142671994.

Polymorphism and mutation databases

BioMutaiDEFB108B.
DMDMi37154739.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PeptideiPRO_000000698123 – 73Beta-defensin 108BAdd BLAST51

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 55By similarity
Disulfide bondi35 ↔ 49By similarity
Disulfide bondi39 ↔ 56By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8NET1.
PRIDEiQ8NET1.

Expressioni

Tissue specificityi

Specifically expressed in testis. Low expression is detected also in liver.1 Publication

Gene expression databases

BgeeiENSG00000184276.
CleanExiHS_DEFB108B.
GenevisibleiQ8NET1. HS.

Organism-specific databases

HPAiHPA042588.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333234.

Structurei

3D structure databases

ProteinModelPortaliQ8NET1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J55W. Eukaryota.
ENOG4111EDS. LUCA.
GeneTreeiENSGT00390000009472.
HOGENOMiHOG000112137.
HOVERGENiHBG081400.
InParanoidiQ8NET1.
OMAiCIETEIH.
OrthoDBiEOG091G13SD.
PhylomeDBiQ8NET1.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NET1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIAVLLFAI FFFMSQVLPA RGKFKEICER PNGSCRDFCL ETEIHVGRCL
60 70
NSQPCCLPLG HQPRIESTTP KKD
Length:73
Mass (Da):8,326
Last modified:September 26, 2003 - v3
Checksum:i6820F297B7C2B7F2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7 – 9LFA → FFT in AAN33116 (PubMed:12734011).Curated3
Sequence conflicti21R → K in AAN33116 (PubMed:12734011).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05924627I → V.Corresponds to variant rs12285436dbSNPEnsembl.1
Natural variantiVAR_04886236R → W.Corresponds to variant rs12793731dbSNPEnsembl.1
Natural variantiVAR_05924745H → L.Corresponds to variant rs12285495dbSNPEnsembl.1
Natural variantiVAR_05924853Q → R.1 PublicationCorresponds to variant rs7120658dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529416 mRNA. Translation: AAQ09525.1.
AY122468 mRNA. Translation: AAM93910.1.
AF540980 mRNA. Translation: AAN33116.1.
CCDSiCCDS31631.1.
RefSeqiNP_001002035.1. NM_001002035.1.
UniGeneiHs.555032.
Hs.583890.

Genome annotation databases

EnsembliENST00000328698; ENSP00000333234; ENSG00000184276.
GeneIDi245911.
KEGGihsa:245911.
UCSCiuc010rqr.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529416 mRNA. Translation: AAQ09525.1.
AY122468 mRNA. Translation: AAM93910.1.
AF540980 mRNA. Translation: AAN33116.1.
CCDSiCCDS31631.1.
RefSeqiNP_001002035.1. NM_001002035.1.
UniGeneiHs.555032.
Hs.583890.

3D structure databases

ProteinModelPortaliQ8NET1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333234.

Polymorphism and mutation databases

BioMutaiDEFB108B.
DMDMi37154739.

Proteomic databases

PaxDbiQ8NET1.
PRIDEiQ8NET1.

Protocols and materials databases

DNASUi245911.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328698; ENSP00000333234; ENSG00000184276.
GeneIDi245911.
KEGGihsa:245911.
UCSCiuc010rqr.2. human.

Organism-specific databases

CTDi245911.
DisGeNETi245911.
GeneCardsiDEFB108B.
HGNCiHGNC:29966. DEFB108B.
HPAiHPA042588.
neXtProtiNX_Q8NET1.
OpenTargetsiENSG00000184276.
PharmGKBiPA142671994.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J55W. Eukaryota.
ENOG4111EDS. LUCA.
GeneTreeiENSGT00390000009472.
HOGENOMiHOG000112137.
HOVERGENiHBG081400.
InParanoidiQ8NET1.
OMAiCIETEIH.
OrthoDBiEOG091G13SD.
PhylomeDBiQ8NET1.

Enzyme and pathway databases

BioCyciZFISH:G66-33536-MONOMER.
ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Miscellaneous databases

GenomeRNAii245911.
PROiQ8NET1.

Gene expression databases

BgeeiENSG00000184276.
CleanExiHS_DEFB108B.
GenevisibleiQ8NET1. HS.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD108B_HUMAN
AccessioniPrimary (citable) accession number: Q8NET1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: September 26, 2003
Last modified: November 2, 2016
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.