ID   DB124_HUMAN             Reviewed;          71 AA.
AC   Q8NES8; Q30E74;
DT   03-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 2.
DT   24-JAN-2024, entry version 120.
DE   RecName: Full=Beta-defensin 124;
DE   AltName: Full=Beta-defensin 24;
DE            Short=DEFB-24;
DE   AltName: Full=Defensin, beta 124;
DE   Flags: Precursor;
GN   Name=DEFB124; Synonyms=DEFB24;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 23-65.
RC   TISSUE=Testis;
RX   PubMed=11854508; DOI=10.1073/pnas.042692699;
RA   Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P.,
RA   Welsh M.J., Casavant T.L., McCray P.B. Jr.;
RT   "Discovery of five conserved beta-defensin gene clusters using a
RT   computational search strategy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- INTERACTION:
CC       Q8NES8; O43639: NCK2; NbExp=3; IntAct=EBI-12843376, EBI-713635;
CC       Q8NES8; O00264: PGRMC1; NbExp=3; IntAct=EBI-12843376, EBI-1045534;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; DQ119827; AAZ81952.1; -; mRNA.
DR   EMBL; AL121751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AY122476; AAM93917.1; -; mRNA.
DR   CCDS; CCDS33457.1; -.
DR   RefSeq; NP_001032589.1; NM_001037500.1.
DR   AlphaFoldDB; Q8NES8; -.
DR   SMR; Q8NES8; -.
DR   BioGRID; 128850; 3.
DR   IntAct; Q8NES8; 2.
DR   STRING; 9606.ENSP00000326309; -.
DR   BioMuta; DEFB124; -.
DR   DMDM; 84028202; -.
DR   PaxDb; 9606-ENSP00000326309; -.
DR   PeptideAtlas; Q8NES8; -.
DR   Antibodypedia; 62850; 55 antibodies from 6 providers.
DR   DNASU; 245937; -.
DR   Ensembl; ENST00000317676.3; ENSP00000326309.2; ENSG00000180383.4.
DR   GeneID; 245937; -.
DR   KEGG; hsa:245937; -.
DR   MANE-Select; ENST00000317676.3; ENSP00000326309.2; NM_001037500.2; NP_001032589.1.
DR   UCSC; uc002wvz.1; human.
DR   AGR; HGNC:18104; -.
DR   CTD; 245937; -.
DR   GeneCards; DEFB124; -.
DR   HGNC; HGNC:18104; DEFB124.
DR   HPA; ENSG00000180383; Tissue enhanced (fallopian tube, testis).
DR   neXtProt; NX_Q8NES8; -.
DR   OpenTargets; ENSG00000180383; -.
DR   PharmGKB; PA38500; -.
DR   VEuPathDB; HostDB:ENSG00000180383; -.
DR   eggNOG; ENOG502TF15; Eukaryota.
DR   GeneTree; ENSGT00530000064308; -.
DR   HOGENOM; CLU_181906_4_0_1; -.
DR   InParanoid; Q8NES8; -.
DR   OMA; FMHLCPD; -.
DR   OrthoDB; 5249246at2759; -.
DR   PhylomeDB; Q8NES8; -.
DR   PathwayCommons; Q8NES8; -.
DR   Reactome; R-HSA-1461957; Beta defensins.
DR   Reactome; R-HSA-1461973; Defensins.
DR   SignaLink; Q8NES8; -.
DR   BioGRID-ORCS; 245937; 11 hits in 1145 CRISPR screens.
DR   GenomeRNAi; 245937; -.
DR   Pharos; Q8NES8; Tbio.
DR   PRO; PR:Q8NES8; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   RNAct; Q8NES8; Protein.
DR   Bgee; ENSG00000180383; Expressed in right uterine tube and 107 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007249; P:canonical NF-kappaB signal transduction; IBA:GO_Central.
DR   GO; GO:0071224; P:cellular response to peptidoglycan; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   GO; GO:0071651; P:positive regulation of chemokine (C-C motif) ligand 5 production; IBA:GO_Central.
DR   GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IBA:GO_Central.
DR   InterPro; IPR025933; Beta_defensin.
DR   PANTHER; PTHR47897; BETA-DEFENSIN 124; 1.
DR   PANTHER; PTHR47897:SF1; BETA-DEFENSIN 124; 1.
DR   Pfam; PF13841; Defensin_beta_2; 1.
DR   Genevisible; Q8NES8; HS.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..71
FT                   /note="Beta-defensin 124"
FT                   /id="PRO_0000045352"
FT   DISULFID        27..54
FT                   /evidence="ECO:0000250"
FT   DISULFID        34..48
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..55
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   71 AA;  8058 MW;  1BF1F37F41E21049 CRC64;
     MTQLLLFLVA LLVLGHVPSG RSEFKRCWKG QGACQTYCTR QETYMHLCPD ASLCCLSYAL
     KPPPVPKHEY E
//