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Protein

Beta-defensin 124

Gene

DEFB124

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.Curated

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 124
Alternative name(s):
Beta-defensin 24
Short name:
DEFB-24
Defensin, beta 124
Gene namesi
Name:DEFB124
Synonyms:DEFB24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:18104. DEFB124.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38500.

Polymorphism and mutation databases

BioMutaiDEFB124.
DMDMi84028202.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 7149Beta-defensin 124PRO_0000045352Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 54By similarity
Disulfide bondi34 ↔ 48By similarity
Disulfide bondi38 ↔ 55By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ8NES8.

Expressioni

Gene expression databases

BgeeiQ8NES8.
CleanExiHS_DEFB124.
GenevisibleiQ8NES8. HS.

Organism-specific databases

HPAiHPA051046.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000326309.

Structurei

3D structure databases

ProteinModelPortaliQ8NES8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG138067.
GeneTreeiENSGT00530000064308.
HOGENOMiHOG000246960.
HOVERGENiHBG095630.
InParanoidiQ8NES8.
OMAiCRTYCTR.
OrthoDBiEOG7V769B.
PhylomeDBiQ8NES8.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NES8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQLLLFLVA LLVLGHVPSG RSEFKRCWKG QGACQTYCTR QETYMHLCPD
60 70
ASLCCLSYAL KPPPVPKHEY E
Length:71
Mass (Da):8,058
Last modified:December 20, 2005 - v2
Checksum:i1BF1F37F41E21049
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ119827 mRNA. Translation: AAZ81952.1.
AL121751 Genomic DNA. No translation available.
AY122476 mRNA. Translation: AAM93917.1.
CCDSiCCDS33457.1.
RefSeqiNP_001032589.1. NM_001037500.1.
UniGeneiHs.381373.

Genome annotation databases

EnsembliENST00000317676; ENSP00000326309; ENSG00000180383.
GeneIDi245937.
KEGGihsa:245937.
UCSCiuc002wvz.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ119827 mRNA. Translation: AAZ81952.1.
AL121751 Genomic DNA. No translation available.
AY122476 mRNA. Translation: AAM93917.1.
CCDSiCCDS33457.1.
RefSeqiNP_001032589.1. NM_001037500.1.
UniGeneiHs.381373.

3D structure databases

ProteinModelPortaliQ8NES8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000326309.

Polymorphism and mutation databases

BioMutaiDEFB124.
DMDMi84028202.

Proteomic databases

PRIDEiQ8NES8.

Protocols and materials databases

DNASUi245937.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317676; ENSP00000326309; ENSG00000180383.
GeneIDi245937.
KEGGihsa:245937.
UCSCiuc002wvz.1. human.

Organism-specific databases

CTDi245937.
GeneCardsiGC20M030053.
HGNCiHGNC:18104. DEFB124.
HPAiHPA051046.
neXtProtiNX_Q8NES8.
PharmGKBiPA38500.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG138067.
GeneTreeiENSGT00530000064308.
HOGENOMiHOG000246960.
HOVERGENiHBG095630.
InParanoidiQ8NES8.
OMAiCRTYCTR.
OrthoDBiEOG7V769B.
PhylomeDBiQ8NES8.

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

GenomeRNAii245937.
NextBioi91812.
PROiQ8NES8.

Gene expression databases

BgeeiQ8NES8.
CleanExiHS_DEFB124.
GenevisibleiQ8NES8. HS.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
    Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
    Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Discovery of five conserved beta-defensin gene clusters using a computational search strategy."
    Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-65.
    Tissue: Testis.

Entry informationi

Entry nameiDB124_HUMAN
AccessioniPrimary (citable) accession number: Q8NES8
Secondary accession number(s): Q30E74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: December 20, 2005
Last modified: June 24, 2015
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.