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Q8NES8

- DB124_HUMAN

UniProt

Q8NES8 - DB124_HUMAN

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Protein

Beta-defensin 124

Gene

DEFB124

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Has antibacterial activity.Curated

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 124
Alternative name(s):
Beta-defensin 24
Short name:
DEFB-24
Defensin, beta 124
Gene namesi
Name:DEFB124
Synonyms:DEFB24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:18104. DEFB124.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38500.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 7149Beta-defensin 124PRO_0000045352Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 54By similarity
Disulfide bondi34 ↔ 48By similarity
Disulfide bondi38 ↔ 55By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ8NES8.

Expressioni

Gene expression databases

BgeeiQ8NES8.
CleanExiHS_DEFB124.
GenevestigatoriQ8NES8.

Organism-specific databases

HPAiHPA051046.

Structurei

3D structure databases

ProteinModelPortaliQ8NES8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG138067.
GeneTreeiENSGT00530000064308.
HOGENOMiHOG000246960.
HOVERGENiHBG095630.
InParanoidiQ8NES8.
OMAiYCTRQES.
OrthoDBiEOG7V769B.
PhylomeDBiQ8NES8.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NES8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQLLLFLVA LLVLGHVPSG RSEFKRCWKG QGACQTYCTR QETYMHLCPD
60 70
ASLCCLSYAL KPPPVPKHEY E
Length:71
Mass (Da):8,058
Last modified:December 20, 2005 - v2
Checksum:i1BF1F37F41E21049
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ119827 mRNA. Translation: AAZ81952.1.
AL121751 Genomic DNA. No translation available.
AY122476 mRNA. Translation: AAM93917.1.
CCDSiCCDS33457.1.
RefSeqiNP_001032589.1. NM_001037500.1.
UniGeneiHs.381373.

Genome annotation databases

EnsembliENST00000317676; ENSP00000326309; ENSG00000180383.
GeneIDi245937.
KEGGihsa:245937.
UCSCiuc002wvz.1. human.

Polymorphism databases

DMDMi84028202.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ119827 mRNA. Translation: AAZ81952.1 .
AL121751 Genomic DNA. No translation available.
AY122476 mRNA. Translation: AAM93917.1 .
CCDSi CCDS33457.1.
RefSeqi NP_001032589.1. NM_001037500.1.
UniGenei Hs.381373.

3D structure databases

ProteinModelPortali Q8NES8.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 84028202.

Proteomic databases

PRIDEi Q8NES8.

Protocols and materials databases

DNASUi 245937.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000317676 ; ENSP00000326309 ; ENSG00000180383 .
GeneIDi 245937.
KEGGi hsa:245937.
UCSCi uc002wvz.1. human.

Organism-specific databases

CTDi 245937.
GeneCardsi GC20M030053.
HGNCi HGNC:18104. DEFB124.
HPAi HPA051046.
neXtProti NX_Q8NES8.
PharmGKBi PA38500.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG138067.
GeneTreei ENSGT00530000064308.
HOGENOMi HOG000246960.
HOVERGENi HBG095630.
InParanoidi Q8NES8.
OMAi YCTRQES.
OrthoDBi EOG7V769B.
PhylomeDBi Q8NES8.

Enzyme and pathway databases

Reactomei REACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

GenomeRNAii 245937.
NextBioi 91812.
PROi Q8NES8.

Gene expression databases

Bgeei Q8NES8.
CleanExi HS_DEFB124.
Genevestigatori Q8NES8.

Family and domain databases

InterProi IPR025933. Beta_defensin.
[Graphical view ]
Pfami PF13841. Defensin_beta_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
    Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
    Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Discovery of five conserved beta-defensin gene clusters using a computational search strategy."
    Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-65.
    Tissue: Testis.

Entry informationi

Entry nameiDB124_HUMAN
AccessioniPrimary (citable) accession number: Q8NES8
Secondary accession number(s): Q30E74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: December 20, 2005
Last modified: October 29, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3