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Q8NES8

- DB124_HUMAN

UniProt

Q8NES8 - DB124_HUMAN

Protein

Beta-defensin 124

Gene

DEFB124

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Has antibacterial activity.Curated

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Defensin

    Enzyme and pathway databases

    ReactomeiREACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-defensin 124
    Alternative name(s):
    Beta-defensin 24
    Short name:
    DEFB-24
    Defensin, beta 124
    Gene namesi
    Name:DEFB124
    Synonyms:DEFB24
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:18104. DEFB124.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38500.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 7149Beta-defensin 124PRO_0000045352Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi27 ↔ 54By similarity
    Disulfide bondi34 ↔ 48By similarity
    Disulfide bondi38 ↔ 55By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ8NES8.

    Expressioni

    Gene expression databases

    BgeeiQ8NES8.
    CleanExiHS_DEFB124.
    GenevestigatoriQ8NES8.

    Organism-specific databases

    HPAiHPA051046.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NES8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-defensin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG138067.
    HOGENOMiHOG000246960.
    HOVERGENiHBG095630.
    InParanoidiQ8NES8.
    OMAiYCTRQES.
    OrthoDBiEOG7V769B.
    PhylomeDBiQ8NES8.

    Family and domain databases

    InterProiIPR025933. Beta_defensin.
    [Graphical view]
    PfamiPF13841. Defensin_beta_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8NES8-1 [UniParc]FASTAAdd to Basket

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    MTQLLLFLVA LLVLGHVPSG RSEFKRCWKG QGACQTYCTR QETYMHLCPD   50
    ASLCCLSYAL KPPPVPKHEY E 71
    Length:71
    Mass (Da):8,058
    Last modified:December 20, 2005 - v2
    Checksum:i1BF1F37F41E21049
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ119827 mRNA. Translation: AAZ81952.1.
    AL121751 Genomic DNA. No translation available.
    AY122476 mRNA. Translation: AAM93917.1.
    CCDSiCCDS33457.1.
    RefSeqiNP_001032589.1. NM_001037500.1.
    UniGeneiHs.381373.

    Genome annotation databases

    EnsembliENST00000317676; ENSP00000326309; ENSG00000180383.
    GeneIDi245937.
    KEGGihsa:245937.
    UCSCiuc002wvz.1. human.

    Polymorphism databases

    DMDMi84028202.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ119827 mRNA. Translation: AAZ81952.1 .
    AL121751 Genomic DNA. No translation available.
    AY122476 mRNA. Translation: AAM93917.1 .
    CCDSi CCDS33457.1.
    RefSeqi NP_001032589.1. NM_001037500.1.
    UniGenei Hs.381373.

    3D structure databases

    ProteinModelPortali Q8NES8.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 84028202.

    Proteomic databases

    PRIDEi Q8NES8.

    Protocols and materials databases

    DNASUi 245937.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000317676 ; ENSP00000326309 ; ENSG00000180383 .
    GeneIDi 245937.
    KEGGi hsa:245937.
    UCSCi uc002wvz.1. human.

    Organism-specific databases

    CTDi 245937.
    GeneCardsi GC20M030053.
    HGNCi HGNC:18104. DEFB124.
    HPAi HPA051046.
    neXtProti NX_Q8NES8.
    PharmGKBi PA38500.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG138067.
    HOGENOMi HOG000246960.
    HOVERGENi HBG095630.
    InParanoidi Q8NES8.
    OMAi YCTRQES.
    OrthoDBi EOG7V769B.
    PhylomeDBi Q8NES8.

    Enzyme and pathway databases

    Reactomei REACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Miscellaneous databases

    GenomeRNAii 245937.
    NextBioi 91812.
    PROi Q8NES8.

    Gene expression databases

    Bgeei Q8NES8.
    CleanExi HS_DEFB124.
    Genevestigatori Q8NES8.

    Family and domain databases

    InterProi IPR025933. Beta_defensin.
    [Graphical view ]
    Pfami PF13841. Defensin_beta_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
      Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
      Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Discovery of five conserved beta-defensin gene clusters using a computational search strategy."
      Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr.
      Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-65.
      Tissue: Testis.

    Entry informationi

    Entry nameiDB124_HUMAN
    AccessioniPrimary (citable) accession number: Q8NES8
    Secondary accession number(s): Q30E74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3