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Q8NES8 (DB124_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-defensin 124
Alternative name(s):
Beta-defensin 24
Short name=DEFB-24
Defensin, beta 124
Gene names
Name:DEFB124
Synonyms:DEFB24
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length71 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has antibacterial activity Potential.

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the beta-defensin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAntibiotic
Antimicrobial
Defensin
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 7149Beta-defensin 124
PRO_0000045352

Amino acid modifications

Disulfide bond27 ↔ 54 By similarity
Disulfide bond34 ↔ 48 By similarity
Disulfide bond38 ↔ 55 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8NES8 [UniParc].

Last modified December 20, 2005. Version 2.
Checksum: 1BF1F37F41E21049

FASTA718,058
        10         20         30         40         50         60 
MTQLLLFLVA LLVLGHVPSG RSEFKRCWKG QGACQTYCTR QETYMHLCPD ASLCCLSYAL 

        70 
KPPPVPKHEY E 

« Hide

References

« Hide 'large scale' references
[1]"Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Discovery of five conserved beta-defensin gene clusters using a computational search strategy."
Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr.
Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-65.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ119827 mRNA. Translation: AAZ81952.1.
AL121751 Genomic DNA. No translation available.
AY122476 mRNA. Translation: AAM93917.1.
RefSeqNP_001032589.1. NM_001037500.1.
UniGeneHs.381373.

3D structure databases

ProteinModelPortalQ8NES8.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM84028202.

Proteomic databases

PRIDEQ8NES8.

Protocols and materials databases

DNASU245937.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000317676; ENSP00000326309; ENSG00000180383.
GeneID245937.
KEGGhsa:245937.
UCSCuc002wvz.1. human.

Organism-specific databases

CTD245937.
GeneCardsGC20M030053.
HGNCHGNC:18104. DEFB124.
HPAHPA051046.
neXtProtNX_Q8NES8.
PharmGKBPA38500.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG138067.
HOGENOMHOG000246960.
HOVERGENHBG095630.
InParanoidQ8NES8.
OMACRTYCTR.
OrthoDBEOG7V769B.
PhylomeDBQ8NES8.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

BgeeQ8NES8.
CleanExHS_DEFB124.
GenevestigatorQ8NES8.

Family and domain databases

InterProIPR025933. Beta_defensin.
[Graphical view]
PfamPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi245937.
NextBio91812.
PROQ8NES8.

Entry information

Entry nameDB124_HUMAN
AccessionPrimary (citable) accession number: Q8NES8
Secondary accession number(s): Q30E74
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: December 20, 2005
Last modified: April 16, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM