Q8NES8 (DB124_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-defensin 124

Alternative name(s):
Beta-defensin 24
Short name=DEFB-24
Defensin, beta 124

Gene names

Name:	DEFB124
Synonyms:	DEFB24

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	71 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has antibacterial activity Potential.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the beta-defensin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Defensin
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 71	49	Beta-defensin 124		PRO_0000045352
Amino acid modifications
	Disulfide bond	27 ↔ 54		By similarity
	Disulfide bond	34 ↔ 48		By similarity
	Disulfide bond	38 ↔ 55		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8NES8 [UniParc]. Last modified December 20, 2005. Version 2. Checksum: 1BF1F37F41E21049	FASTA	71	8,058
	10 20 30 40 50 60 MTQLLLFLVA LLVLGHVPSG RSEFKRCWKG QGACQTYCTR QETYMHLCPD ASLCCLSYAL 70 KPPPVPKHEY E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract." Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G. Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Discovery of five conserved beta-defensin gene clusters using a computational search strategy." Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr. Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-65. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ119827 mRNA. Translation: AAZ81952.1. AL121751 Genomic DNA. No translation available. AY122476 mRNA. Translation: AAM93917.1.
IPI	IPI00171622.
RefSeq	NP_001032589.1. NM_001037500.1.
UniGene	Hs.381373.
3D structure databases
ProteinModelPortal	Q8NES8.
ModBase	Search...
Polymorphism databases
DMDM	84028202.
Proteomic databases
PRIDE	Q8NES8.
Protocols and materials databases
DNASU	245937.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000317676; ENSP00000326309; ENSG00000180383.
GeneID	245937.
KEGG	hsa:245937.
UCSC	uc002wvz.1. human.
Organism-specific databases
CTD	245937.
GeneCards	GC20M030053.
HGNC	HGNC:18104. DEFB124.
HPA	HPA051046.
neXtProt	NX_Q8NES8.
PharmGKB	PA38500.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG138067.
HOGENOM	HOG000246960.
HOVERGEN	HBG095630.
InParanoid	Q8NES8.
OMA	CRTYCTR.
OrthoDB	EOG4K9BDX.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
Bgee	Q8NES8.
CleanEx	HS_DEFB124.
Genevestigator	Q8NES8.
GermOnline	ENSG00000180383. Homo sapiens.
Family and domain databases
InterPro	IPR025933. Beta_defensin. [Graphical view]
Pfam	PF13841. Defensin_beta_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	91812.

Entry information

Entry name

DB124_HUMAN

Accession

Primary (citable) accession number: Q8NES8
Secondary accession number(s): Q30E74

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	December 20, 2005
Last modified:	April 3, 2013
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.