##gff-version 3 Q8NES3 UniProtKB Chain 1 379 . . . ID=PRO_0000219176;Note=Beta-1%2C3-N-acetylglucosaminyltransferase lunatic fringe Q8NES3 UniProtKB Topological domain 1 8 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NES3 UniProtKB Transmembrane 9 29 . . . Note=Helical%3B Signal-anchor for type II membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NES3 UniProtKB Topological domain 30 379 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NES3 UniProtKB Region 86 107 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8NES3 UniProtKB Compositional bias 91 105 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8NES3 UniProtKB Active site 290 290 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8NES3 UniProtKB Binding site 129 129 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8NES3 UniProtKB Binding site 201 201 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8NES3 UniProtKB Binding site 202 202 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8NES3 UniProtKB Binding site 314 314 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8NES3 UniProtKB Site 86 87 . . . Note=Cleavage%3B by furin-like protease;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NES3 UniProtKB Glycosylation 167 167 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NES3 UniProtKB Disulfide bond 168 179 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8NES3 UniProtKB Disulfide bond 197 260 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8NES3 UniProtKB Disulfide bond 364 373 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8NES3 UniProtKB Alternative sequence 1 129 . . . ID=VSP_001792;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q8NES3 UniProtKB Alternative sequence 1 73 . . . ID=VSP_044850;Note=In isoform 4. MLKRCGRRLLLALAGALLACLLVLTADPPPPPLPAERGRRALRSLAGPAGAAPAPGLGAAAAAPGALVRDVHS->MDEQTGRLRLDTYCMSAKQIWAWSKCSGRLWDEHMKWMEGWTDRWTDGWMDGWMDEWSPTPALRSYGGGLSQQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q8NES3 UniProtKB Alternative sequence 74 144 . . . ID=VSP_044851;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q8NES3 UniProtKB Alternative sequence 130 145 . . . ID=VSP_001793;Note=In isoform 2. LDLLLETWISRHKEMT->MTPGRCCLAADIQVET;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q8NES3 UniProtKB Alternative sequence 359 361 . . . ID=VSP_001794;Note=In isoform 3. FRS->WGN;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:9187150,ECO:0000303|Ref.5;Dbxref=PMID:9187150 Q8NES3 UniProtKB Alternative sequence 362 379 . . . ID=VSP_001795;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:9187150,ECO:0000303|Ref.5;Dbxref=PMID:9187150 Q8NES3 UniProtKB Natural variant 38 38 . . . ID=VAR_046785;Note=G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18485326;Dbxref=PMID:18485326 Q8NES3 UniProtKB Natural variant 188 188 . . . ID=VAR_025850;Note=In SCDO3%3B likely pathogenic%3B loss-of-function variant%3B the mutant mouse protein is enzymatically inactive and unable to modulate Notch signaling in a cell-based assay. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16385447;Dbxref=dbSNP:rs104894024,PMID:16385447 Q8NES3 UniProtKB Natural variant 201 201 . . . ID=VAR_088492;Note=In SCDO3%3B likely pathogenic%3B loss of acetylglucosaminyltransferase activity. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30531807;Dbxref=PMID:30531807 Q8NES3 UniProtKB Natural variant 346 346 . . . ID=VAR_046786;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18485326;Dbxref=dbSNP:rs71647813,PMID:18485326 Q8NES3 UniProtKB Sequence conflict 104 104 . . . Note=R->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8NES3 UniProtKB Sequence conflict 212 212 . . . Note=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8NES3 UniProtKB Sequence conflict 221 221 . . . Note=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8NES3 UniProtKB Sequence conflict 297 297 . . . Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305