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Q8NER1

- TRPV1_HUMAN

UniProt

Q8NER1 - TRPV1_HUMAN

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Protein

Transient receptor potential cation channel subfamily V member 1

Gene

TRPV1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis By similarity. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca2+-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel.By similarity4 Publications

Enzyme regulationi

Channel activity is activated via the interaction with PIRT and phosphatidylinositol 4,5-bisphosphate (PIP2). Both PIRT and PIP2 are required to activate channel activity By similarity. The channel is sensitized by ATP binding. Repeated stimulation with capsaicin gives rise to progressively smaller responses, due to desensitization. This desensitization is triggered by the influx of calcium ions and is inhibited by elevated ATP levels. Ca2+ and CALM displace ATP from its binding site and trigger a conformation change that leads to a closed, desensitized channel. Intracellular PIP2 inhibits desensitization. The double-knot toxin (DkTx) from the Chinese earth tiger tarantula activates the channel and traps it in an open conformation By similarity.By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. calcium channel activity Source: ProtInc
  3. calcium-release channel activity Source: UniProtKB
  4. excitatory extracellular ligand-gated ion channel activity Source: UniProtKB
  5. phosphoprotein binding Source: UniProt
  6. transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

  1. calcium ion transmembrane transport Source: UniProtKB
  2. cell surface receptor signaling pathway Source: ProtInc
  3. cellular response to alkaloid Source: UniProtKB
  4. cellular response to ATP Source: UniProtKB
  5. chemosensory behavior Source: ProtInc
  6. ion transmembrane transport Source: Reactome
  7. thermoception Source: MGI
  8. transmembrane transport Source: Reactome
  9. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_169333. TRP channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily V member 1
Short name:
TrpV1
Alternative name(s):
Capsaicin receptor
Osm-9-like TRP channel 1
Short name:
OTRPC1
Vanilloid receptor 1
Gene namesi
Name:TRPV1
Synonyms:VR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:12716. TRPV1.

Subcellular locationi

Cell junctionsynapsepostsynaptic cell membrane By similarity; Multi-pass membrane protein By similarity. Cell projectiondendritic spine membrane By similarity; Multi-pass membrane protein By similarity. Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Mostly, but not exclusively expressed in postsynaptic dendritic spines.By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cell projection Source: UniProtKB-KW
  3. integral component of membrane Source: MGI
  4. integral component of plasma membrane Source: ProtInc
  5. intrinsic component of plasma membrane Source: UniProtKB
  6. plasma membrane Source: Reactome
  7. postsynaptic membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi511 – 5111Y → A: Loss of sensitivity to capsaicin. 1 Publication
Mutagenesisi550 – 5501T → I: Reduces sensitivity to capsaicin 40-fold. 1 Publication

Organism-specific databases

PharmGKBiPA37329.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 839839Transient receptor potential cation channel subfamily V member 1PRO_0000215338Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei117 – 1171PhosphoserineBy similarity
Modified residuei145 – 1451PhosphothreonineBy similarity
Modified residuei371 – 3711PhosphothreonineBy similarity
Modified residuei502 – 5021Phosphoserine; by PKC/PRKCEBy similarity
Glycosylationi604 – 6041N-linked (GlcNAc...)By similarity
Modified residuei705 – 7051PhosphothreonineBy similarity
Modified residuei775 – 7751PhosphoserineBy similarity
Modified residuei801 – 8011Phosphoserine; by PKC/PRKCEBy similarity
Modified residuei821 – 8211PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phoshphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PRKCE, PRKCM and probably PRKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity By similarity.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8NER1.
PRIDEiQ8NER1.

PTM databases

PhosphoSiteiQ8NER1.

Expressioni

Tissue specificityi

Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).3 Publications

Gene expression databases

BgeeiQ8NER1.
CleanExiHS_TRPV1.
ExpressionAtlasiQ8NER1. baseline.
GenevestigatoriQ8NER1.

Interactioni

Subunit structurei

Homotetramer. Interacts with CALM, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex. Interacts with PIRT By similarity. Interacts with TRPV3 and may also form a heteromeric channel with TRPV3.By similarity1 Publication

Protein-protein interaction databases

BioGridi113281. 7 interactions.
MINTiMINT-4721979.
STRINGi9606.ENSP00000174621.

Structurei

3D structure databases

ProteinModelPortaliQ8NER1.
SMRiQ8NER1. Positions 112-720.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 433433CytoplasmicBy similarityAdd
BLAST
Topological domaini455 – 47117ExtracellularBy similarityAdd
BLAST
Topological domaini498 – 51013CytoplasmicBy similarityAdd
BLAST
Topological domaini532 – 5354ExtracellularBy similarity
Topological domaini557 – 57115CytoplasmicBy similarityAdd
BLAST
Topological domaini600 – 62728ExtracellularBy similarityAdd
BLAST
Topological domaini688 – 839152CytoplasmicBy similarityAdd
BLAST

Intramembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei628 – 65023Pore-formingBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei434 – 45421HelicalBy similarityAdd
BLAST
Transmembranei472 – 49726HelicalBy similarityAdd
BLAST
Transmembranei511 – 53121HelicalBy similarityAdd
BLAST
Transmembranei536 – 55621HelicalBy similarityAdd
BLAST
Transmembranei572 – 59928HelicalBy similarityAdd
BLAST
Transmembranei659 – 68729HelicalBy similarityAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati111 – 15343ANK 1Add
BLAST
Repeati154 – 20047ANK 2Add
BLAST
Repeati201 – 24747ANK 3Add
BLAST
Repeati248 – 28336ANK 4Add
BLAST
Repeati284 – 33249ANK 5Add
BLAST
Repeati333 – 35927ANK 6Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni685 – 71329ADBy similarityAdd
BLAST
Regioni768 – 80235Interaction with calmodulinBy similarityAdd
BLAST
Regioni778 – 79316Required for PIP2-mediated channel inhibitionBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi644 – 6474Selectivity filterBy similarity

Domaini

The association domain (AD) is necessary for self-association.By similarity

Sequence similaritiesi

Contains 6 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG278734.
GeneTreeiENSGT00550000074425.
HOVERGENiHBG054085.
InParanoidiQ8NER1.
KOiK05222.
OrthoDBiEOG7WHH8R.
PhylomeDBiQ8NER1.
TreeFamiTF314711.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR004729. TRP_channel.
IPR008347. TRPV1-4_channel.
IPR024863. TRPV1_channel.
[Graphical view]
PANTHERiPTHR10582:SF17. PTHR10582:SF17. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01768. TRPVRECEPTOR.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NER1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKWSSTDLG AAADPLQKDT CPDPLDGDPN SRPPPAKPQL STAKSRTRLF
60 70 80 90 100
GKGDSEEAFP VDCPHEEGEL DSCPTITVSP VITIQRPGDG PTGARLLSQD
110 120 130 140 150
SVAASTEKTL RLYDRRSIFE AVAQNNCQDL ESLLLFLQKS KKHLTDNEFK
160 170 180 190 200
DPETGKTCLL KAMLNLHDGQ NTTIPLLLEI ARQTDSLKEL VNASYTDSYY
210 220 230 240 250
KGQTALHIAI ERRNMALVTL LVENGADVQA AAHGDFFKKT KGRPGFYFGE
260 270 280 290 300
LPLSLAACTN QLGIVKFLLQ NSWQTADISA RDSVGNTVLH ALVEVADNTA
310 320 330 340 350
DNTKFVTSMY NEILMLGAKL HPTLKLEELT NKKGMTPLAL AAGTGKIGVL
360 370 380 390 400
AYILQREIQE PECRHLSRKF TEWAYGPVHS SLYDLSCIDT CEKNSVLEVI
410 420 430 440 450
AYSSSETPNR HDMLLVEPLN RLLQDKWDRF VKRIFYFNFL VYCLYMIIFT
460 470 480 490 500
MAAYYRPVDG LPPFKMEKTG DYFRVTGEIL SVLGGVYFFF RGIQYFLQRR
510 520 530 540 550
PSMKTLFVDS YSEMLFFLQS LFMLATVVLY FSHLKEYVAS MVFSLALGWT
560 570 580 590 600
NMLYYTRGFQ QMGIYAVMIE KMILRDLCRF MFVYIVFLFG FSTAVVTLIE
610 620 630 640 650
DGKNDSLPSE STSHRWRGPA CRPPDSSYNS LYSTCLELFK FTIGMGDLEF
660 670 680 690 700
TENYDFKAVF IILLLAYVIL TYILLLNMLI ALMGETVNKI AQESKNIWKL
710 720 730 740 750
QRAITILDTE KSFLKCMRKA FRSGKLLQVG YTPDGKDDYR WCFRVDEVNW
760 770 780 790 800
TTWNTNVGII NEDPGNCEGV KRTLSFSLRS SRVSGRHWKN FALVPLLREA
810 820 830
SARDRQSAQP EEVYLRQFSG SLKPEDAEVF KSPAASGEK
Length:839
Mass (Da):94,956
Last modified:May 18, 2010 - v2
Checksum:i7142F59D428827FB
GO
Isoform 2 (identifier: Q8NER1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-150: MKKWSSTDLG...KKHLTDNEFK → METLTPGHLQ...ACPDPPLCLS

Show »
Length:837
Mass (Da):94,211
Checksum:iD662DD6094BDCA56
GO

Sequence cautioni

The sequence AAG43467.1 differs from that shown. Reason: Frameshift at position 498.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti336 – 3361T → M in CAB89866. (PubMed:11226139)Curated
Sequence conflicti552 – 5521M → V in ABA06605. 1 Publication1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti91 – 911P → S.1 Publication
Corresponds to variant rs222749 [ dbSNP | Ensembl ].
VAR_057307
Natural varianti315 – 3151M → I.
Corresponds to variant rs222747 [ dbSNP | Ensembl ].
VAR_071244
Natural varianti469 – 4691T → I.2 Publications
Corresponds to variant rs224534 [ dbSNP | Ensembl ].
VAR_057308
Natural varianti505 – 5051T → A.
Corresponds to variant rs17633288 [ dbSNP | Ensembl ].
VAR_057309
Natural varianti585 – 5851I → V.1 Publication
Corresponds to variant rs8065080 [ dbSNP | Ensembl ].
VAR_022246

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 150150MKKWS…DNEFK → METLTPGHLQPSPSSPRPRA APGSLGRVTRRRLSRWIALT RKVSWTPARPSQSALLSPSR GQETAPPVPGCCPRTLSPPA PRRPSGSMIAGVSLKPLLRI TARIWRACCSSCRRARSTSQ TTSSKVAPALGSGRAPALAC PDPPLCLS in isoform 2. 1 PublicationVSP_056862Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ277028 mRNA. Translation: CAB95729.1.
AF196175 mRNA. Translation: AAG43466.1.
AF196176 mRNA. Translation: AAG43467.1. Frameshift.
AJ272063 mRNA. Translation: CAB89866.2.
AY131289 mRNA. Translation: AAM89472.1.
DQ177332 mRNA. Translation: ABA06605.1.
AL136801 mRNA. Translation: CAB66735.1.
AC027796 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90497.1.
BC132820 mRNA. Translation: AAI32821.1.
BC136633 mRNA. Translation: AAI36634.1.
CCDSiCCDS45576.1.
PIRiJC7621.
RefSeqiNP_061197.4. NM_018727.5.
NP_542435.2. NM_080704.3.
NP_542436.2. NM_080705.3.
NP_542437.2. NM_080706.3.
UniGeneiHs.579217.
Hs.655380.

Genome annotation databases

EnsembliENST00000572705; ENSP00000459962; ENSG00000262304.
GeneIDi7442.
KEGGihsa:7442.
UCSCiuc010vrr.2. human.

Polymorphism databases

DMDMi296452849.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ277028 mRNA. Translation: CAB95729.1 .
AF196175 mRNA. Translation: AAG43466.1 .
AF196176 mRNA. Translation: AAG43467.1 . Frameshift.
AJ272063 mRNA. Translation: CAB89866.2 .
AY131289 mRNA. Translation: AAM89472.1 .
DQ177332 mRNA. Translation: ABA06605.1 .
AL136801 mRNA. Translation: CAB66735.1 .
AC027796 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90497.1 .
BC132820 mRNA. Translation: AAI32821.1 .
BC136633 mRNA. Translation: AAI36634.1 .
CCDSi CCDS45576.1.
PIRi JC7621.
RefSeqi NP_061197.4. NM_018727.5.
NP_542435.2. NM_080704.3.
NP_542436.2. NM_080705.3.
NP_542437.2. NM_080706.3.
UniGenei Hs.579217.
Hs.655380.

3D structure databases

ProteinModelPortali Q8NER1.
SMRi Q8NER1. Positions 112-720.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113281. 7 interactions.
MINTi MINT-4721979.
STRINGi 9606.ENSP00000174621.

Chemistry

BindingDBi Q8NER1.
ChEMBLi CHEMBL4794.
DrugBanki DB00132. Alpha-Linolenic Acid.
DB00168. Aspartame.
DB00159. Icosapent.
GuidetoPHARMACOLOGYi 507.

PTM databases

PhosphoSitei Q8NER1.

Polymorphism databases

DMDMi 296452849.

Proteomic databases

PaxDbi Q8NER1.
PRIDEi Q8NER1.

Protocols and materials databases

DNASUi 7442.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000572705 ; ENSP00000459962 ; ENSG00000262304 .
GeneIDi 7442.
KEGGi hsa:7442.
UCSCi uc010vrr.2. human.

Organism-specific databases

CTDi 7442.
GeneCardsi GC17M003471.
H-InvDB HIX0013428.
HIX0079948.
HGNCi HGNC:12716. TRPV1.
MIMi 602076. gene.
neXtProti NX_Q8NER1.
PharmGKBi PA37329.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG278734.
GeneTreei ENSGT00550000074425.
HOVERGENi HBG054085.
InParanoidi Q8NER1.
KOi K05222.
OrthoDBi EOG7WHH8R.
PhylomeDBi Q8NER1.
TreeFami TF314711.

Enzyme and pathway databases

Reactomei REACT_169333. TRP channels.

Miscellaneous databases

GeneWikii TRPV1.
GenomeRNAii 7442.
NextBioi 29140.
PROi Q8NER1.
SOURCEi Search...

Gene expression databases

Bgeei Q8NER1.
CleanExi HS_TRPV1.
ExpressionAtlasi Q8NER1. baseline.
Genevestigatori Q8NER1.

Family and domain databases

Gene3Di 1.25.40.20. 2 hits.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR004729. TRP_channel.
IPR008347. TRPV1-4_channel.
IPR024863. TRPV1_channel.
[Graphical view ]
PANTHERi PTHR10582:SF17. PTHR10582:SF17. 1 hit.
Pfami PF12796. Ank_2. 1 hit.
[Graphical view ]
PRINTSi PR01768. TRPVRECEPTOR.
SMARTi SM00248. ANK. 4 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
TIGRFAMsi TIGR00870. trp. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANTS ILE-315 AND VAL-585.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANTS SER-91; ILE-315 AND ILE-469.
    Tissue: Spinal ganglion.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, VARIANT ILE-315.
    Tissue: Spinal ganglion.
  4. Lee D., Ha I.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-315.
    Tissue: Brain.
  5. "Isolation and characterization of a human TRPV1 splice variant."
    Lu L., Mansson E.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS ILE-315 AND VAL-585, ALTERNATIVE SPLICING.
    Tissue: Pancreas.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ILE-315 AND ILE-469.
    Tissue: Testis.
  7. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-315.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-315.
    Tissue: Brain.
  10. Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TRPV3.
  11. "Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures."
    Staender S., Moormann C., Schumacher M., Buddenkotte J., Artuc M., Shpacovitch V., Brzoska T., Lippert U., Henz B.M., Luger T.A., Metze D., Steinhoff M.
    Exp. Dermatol. 13:129-139(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  12. Cited for: MUTAGENESIS OF TYR-511 AND THR-550.

Entry informationi

Entry nameiTRPV1_HUMAN
AccessioniPrimary (citable) accession number: Q8NER1
Secondary accession number(s): A2RUA9
, Q3LU47, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3