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Protein

Steroid receptor-associated and regulated protein

Gene

SRARP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May regulate the transcriptional function of androgen and estrogen receptors.2 Publications

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid receptor-associated and regulated proteinImported
Alternative name(s):
ER-related factor1 Publication
Steroid receptor-regulated protein1 Publication
Gene namesi
Name:SRARPImported
Synonyms:C1orf64, ERRF1 Publication, SSPR1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000183888.4.
HGNCiHGNC:28339. SRARP.

Pathology & Biotechi

Organism-specific databases

DisGeNETi149563.
OpenTargetsiENSG00000183888.
PharmGKBiPA142672514.

Polymorphism and mutation databases

BioMutaiC1orf64.
DMDMi74751258.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002471241 – 169Steroid receptor-associated and regulated proteinAdd BLAST169

Proteomic databases

PaxDbiQ8NEQ6.
PeptideAtlasiQ8NEQ6.
PRIDEiQ8NEQ6.

PTM databases

iPTMnetiQ8NEQ6.
PhosphoSitePlusiQ8NEQ6.

Expressioni

Tissue specificityi

Expressed in breast tumors with a higher expression level in estrogen receptor-positive cancers (PubMed:22341523, PubMed:28915724).2 Publications

Inductioni

Up-regulated in breast cancers (PubMed:22341523).1 Publication

Gene expression databases

BgeeiENSG00000183888.
CleanExiHS_C1orf64.
GenevisibleiQ8NEQ6. HS.

Organism-specific databases

HPAiHPA026676.

Interactioni

Subunit structurei

Interacts with 14-3-3 proteins (PubMed:28915724).1 Publication

Protein-protein interaction databases

BioGridi127222. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ8NEQ6.
SMRiQ8NEQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J0N6. Eukaryota.
ENOG41114KN. LUCA.
GeneTreeiENSGT00390000000265.
HOGENOMiHOG000065780.
HOVERGENiHBG080949.
InParanoidiQ8NEQ6.
OMAiPPMKTYI.
OrthoDBiEOG091G0VGY.
PhylomeDBiQ8NEQ6.
TreeFamiTF338217.

Family and domain databases

InterProiView protein in InterPro
IPR027852. DUF4654.
PANTHERiPTHR38494. PTHR38494. 1 hit.
PfamiView protein in Pfam
PF15547. DUF4654. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NEQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSEDPRDW RANLKGTIRE TGLETSSGGK LAGHQKTVPT AHLTFVIDCT
60 70 80 90 100
HGKQLSLAAT ASPPQAPSPN RGLVTPPMKT YIVFCGENWP HLTRVTPMGG
110 120 130 140 150
GCLAQARATL PLCRGSVASA SFPVSPLCPQ EVPEAKGKPV KAAPVRSSTW
160
GTVKDSLKAL SSCVCGQAD
Length:169
Mass (Da):17,657
Last modified:October 1, 2002 - v1
Checksum:i53902A504A22451D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03549152G → W in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_035492100G → W in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_033654112L → F. Corresponds to variant dbSNP:rs34950166Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127425 mRNA. Translation: BAG54501.1.
AL355994 Genomic DNA. No translation available.
CH471167 Genomic DNA. Translation: EAW51759.1.
BC017946 mRNA. Translation: AAH17946.1.
CCDSiCCDS166.1.
RefSeqiNP_849162.1. NM_178840.3.
UniGeneiHs.29190.

Genome annotation databases

EnsembliENST00000329454; ENSP00000332162; ENSG00000183888.
GeneIDi149563.
KEGGihsa:149563.
UCSCiuc001axn.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSRARP_HUMAN
AccessioniPrimary (citable) accession number: Q8NEQ6
Secondary accession number(s): B3KXI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: November 22, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations