Q8NEP9 (ZN555_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 555

Gene names

Name:

ZNF555

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	628 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 15 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NEP9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NEP9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     105-105: Missing.
     451-453: PYE → LYK
     460-543: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 628	628	Zinc finger protein 555		PRO_0000234588
Regions
	Domain	4 – 77	74	KRAB
	Zinc finger	172 – 194	23	C2H2-type 1; degenerate
	Zinc finger	200 – 222	23	C2H2-type 2
	Zinc finger	228 – 250	23	C2H2-type 3
	Zinc finger	256 – 278	23	C2H2-type 4
	Zinc finger	284 – 306	23	C2H2-type 5
	Zinc finger	312 – 334	23	C2H2-type 6
	Zinc finger	340 – 362	23	C2H2-type 7
	Zinc finger	368 – 390	23	C2H2-type 8
	Zinc finger	396 – 418	23	C2H2-type 9
	Zinc finger	424 – 446	23	C2H2-type 10
	Zinc finger	452 – 474	23	C2H2-type 11
	Zinc finger	480 – 502	23	C2H2-type 12
	Zinc finger	508 – 530	23	C2H2-type 13
	Zinc finger	536 – 558	23	C2H2-type 14
	Zinc finger	564 – 586	23	C2H2-type 15
Natural variations
	Alternative sequence	105	1	Missing in isoform 2.		VSP_018382
	Alternative sequence	451 – 453	3	PYE → LYK in isoform 2.		VSP_018383
	Alternative sequence	460 – 543	84	Missing in isoform 2.		VSP_018384
	Natural variant	107	1	N → D. Ref.4 Corresponds to variant rs17856649 [ dbSNP | Ensembl ].		VAR_054223
	Natural variant	137	1	P → L. Corresponds to variant rs36012545 [ dbSNP | Ensembl ].		VAR_054224
	Natural variant	194	1	H → N. Ref.4 Corresponds to variant rs17851955 [ dbSNP | Ensembl ].		VAR_054225
	Natural variant	515	1	K → T. Ref.4 Corresponds to variant rs17856648 [ dbSNP | Ensembl ].		VAR_026295

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 20, 2009. Version 4. Checksum: D9C3B651D0B2FDE0	FASTA	628	73,084
	10 20 30 40 50 60 MDSVVFEDVA VDFTLEEWAL LDSAQRDLYR DVMLETFQNL ASVDDETQFK ASGSVSQQDI 70 80 90 100 110 120 YGEKIPKESK IATFTRNVSW ASVLGKIWDS LSIEDQTTNQ GRNLSRNHGL ERLCESNDQC 130 140 150 160 170 180 GEALSQIPHL NLYKKIPPGV KQYEYNTYGK VFMHRRTSLK SPITVHTGHK PYQCQECGQA 190 200 210 220 230 240 YSCRSHLRMH VRTHNGERPY VCKLCGKTFP RTSSLNRHVR IHTAEKTYEC KQCGKAFIDF 250 260 270 280 290 300 SSLTSHLRSH TGEKPYKCKE CGKAFSYSST FRRHTITHTG EKPYKCKECA EAFSYSSTFR 310 320 330 340 350 360 RHMISHTGEK PHKCKECGEA FSYSSAFRRH MITHTGEKPY ECKQCGKTFI YLQSFRRHER 370 380 390 400 410 420 IHTGEKPYEC KQCGKTFIYP QSFRRHERTH GGEKPYECNQ CGKAFSHPSS FRGHMRVHTG 430 440 450 460 470 480 EKPYECKQCG KTFNWPISLR KHMRTHTREK PYECKQCGKA FSLSACFREH VRMHPEDKSY 490 500 510 520 530 540 ECKLCGKAFY CHISLQKHMR RHTAEKLYKC KQCGKAFSWP ELLQQHVRTH TVEKPYECKE 550 560 570 580 590 600 CGKVFKWPSS LPIHMRLHTG EKPYQCKHCG KAFNCSSSLR RHVRIHTTEK QYKCNVGHPP 610 620 ANEFMCSASE KSHQERDLIK VVNMVLPL
	Isoform 2 [UniParc]. Checksum: 370044FF6CA635E0	FASTA	543	63,040
	10 20 30 40 50 60 MDSVVFEDVA VDFTLEEWAL LDSAQRDLYR DVMLETFQNL ASVDDETQFK ASGSVSQQDI 70 80 90 100 110 120 YGEKIPKESK IATFTRNVSW ASVLGKIWDS LSIEDQTTNQ GRNLRNHGLE RLCESNDQCG 130 140 150 160 170 180 EALSQIPHLN LYKKIPPGVK QYEYNTYGKV FMHRRTSLKS PITVHTGHKP YQCQECGQAY 190 200 210 220 230 240 SCRSHLRMHV RTHNGERPYV CKLCGKTFPR TSSLNRHVRI HTAEKTYECK QCGKAFIDFS 250 260 270 280 290 300 SLTSHLRSHT GEKPYKCKEC GKAFSYSSTF RRHTITHTGE KPYKCKECAE AFSYSSTFRR 310 320 330 340 350 360 HMISHTGEKP HKCKECGEAF SYSSAFRRHM ITHTGEKPYE CKQCGKTFIY LQSFRRHERI 370 380 390 400 410 420 HTGEKPYECK QCGKTFIYPQ SFRRHERTHG GEKPYECNQC GKAFSHPSSF RGHMRVHTGE 430 440 450 460 470 480 KPYECKQCGK TFNWPISLRK HMRTHTREKL YKCKQCGKVF KWPSSLPIHM RLHTGEKPYQ 490 500 510 520 530 540 CKHCGKAFNC SSSLRRHVRI HTTEKQYKCN VGHPPANEFM CSASEKSHQE RDLIKVVNMV LPL

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Colon endothelium.
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ASP-107; ASN-194 AND THR-515. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK093163 mRNA. Translation: BAC04082.1. BX647423 mRNA. No translation available. AC006130 Genomic DNA. No translation available. BC022022 mRNA. Translation: AAH22022.2.
IPI	IPI00167903. IPI00402144.
RefSeq	NP_690004.4. NM_152791.4.
UniGene	Hs.47712.
3D structure databases
ProteinModelPortal	Q8NEP9.
ModBase	Search...
PTM databases
PhosphoSite	Q8NEP9.
Polymorphism databases
DMDM	221222537.
Proteomic databases
PaxDb	Q8NEP9.
PRIDE	Q8NEP9.
Protocols and materials databases
DNASU	148254.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000334241; ENSP00000334853; ENSG00000186300.
GeneID	148254.
KEGG	hsa:148254.
UCSC	uc002lwo.3. human.
Organism-specific databases
CTD	148254.
GeneCards	GC19P002841.
HGNC	HGNC:28382. ZNF555.
HPA	HPA053956. HPA055430.
neXtProt	NX_Q8NEP9.
PharmGKB	PA134956715.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q8NEP9.
KO	K09228.
OMA	YSSTFRR.
PhylomeDB	Q8NEP9.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
Bgee	Q8NEP9.
CleanEx	HS_ZNF555.
Genevestigator	Q8NEP9.
GermOnline	ENSG00000186300. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 15 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 15 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 15 hits. PS50157. ZINC_FINGER_C2H2_2. 15 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	148254.
NextBio	85887.

Entry information

Entry name

ZN555_HUMAN

Accession

Primary (citable) accession number: Q8NEP9
Secondary accession number(s): Q8NA46, Q96MP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	January 20, 2009
Last modified:	May 1, 2013
This is version 102 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.