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Protein

Zinc finger protein 555

Gene

ZNF555

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 194C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri536 – 558C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri564 – 586C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-32281-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 555
Gene namesi
Name:ZNF555
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28382. ZNF555.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186300.
PharmGKBiPA134956715.

Polymorphism and mutation databases

BioMutaiZNF555.
DMDMi221222537.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345881 – 628Zinc finger protein 555Add BLAST628

Proteomic databases

EPDiQ8NEP9.
MaxQBiQ8NEP9.
PaxDbiQ8NEP9.
PeptideAtlasiQ8NEP9.
PRIDEiQ8NEP9.

PTM databases

iPTMnetiQ8NEP9.
PhosphoSitePlusiQ8NEP9.

Expressioni

Gene expression databases

BgeeiENSG00000186300.
CleanExiHS_ZNF555.
ExpressionAtlasiQ8NEP9. baseline and differential.
GenevisibleiQ8NEP9. HS.

Organism-specific databases

HPAiHPA053956.
HPA055430.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-10270752,EBI-748961
CEP70Q8NHQ13EBI-10270752,EBI-739624
KRTAP10-7P604093EBI-10270752,EBI-10172290

Protein-protein interaction databases

BioGridi127136. 6 interactors.
IntActiQ8NEP9. 3 interactors.
STRINGi9606.ENSP00000334853.

Structurei

3D structure databases

ProteinModelPortaliQ8NEP9.
SMRiQ8NEP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 77KRABPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 194C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri536 – 558C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri564 – 586C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8NEP9.
KOiK09228.
OMAiYSSTFRR.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8NEP9.
TreeFamiTF338854.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NEP9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSVVFEDVA VDFTLEEWAL LDSAQRDLYR DVMLETFQNL ASVDDETQFK
60 70 80 90 100
ASGSVSQQDI YGEKIPKESK IATFTRNVSW ASVLGKIWDS LSIEDQTTNQ
110 120 130 140 150
GRNLSRNHGL ERLCESNDQC GEALSQIPHL NLYKKIPPGV KQYEYNTYGK
160 170 180 190 200
VFMHRRTSLK SPITVHTGHK PYQCQECGQA YSCRSHLRMH VRTHNGERPY
210 220 230 240 250
VCKLCGKTFP RTSSLNRHVR IHTAEKTYEC KQCGKAFIDF SSLTSHLRSH
260 270 280 290 300
TGEKPYKCKE CGKAFSYSST FRRHTITHTG EKPYKCKECA EAFSYSSTFR
310 320 330 340 350
RHMISHTGEK PHKCKECGEA FSYSSAFRRH MITHTGEKPY ECKQCGKTFI
360 370 380 390 400
YLQSFRRHER IHTGEKPYEC KQCGKTFIYP QSFRRHERTH GGEKPYECNQ
410 420 430 440 450
CGKAFSHPSS FRGHMRVHTG EKPYECKQCG KTFNWPISLR KHMRTHTREK
460 470 480 490 500
PYECKQCGKA FSLSACFREH VRMHPEDKSY ECKLCGKAFY CHISLQKHMR
510 520 530 540 550
RHTAEKLYKC KQCGKAFSWP ELLQQHVRTH TVEKPYECKE CGKVFKWPSS
560 570 580 590 600
LPIHMRLHTG EKPYQCKHCG KAFNCSSSLR RHVRIHTTEK QYKCNVGHPP
610 620
ANEFMCSASE KSHQERDLIK VVNMVLPL
Length:628
Mass (Da):73,084
Last modified:January 20, 2009 - v4
Checksum:iD9C3B651D0B2FDE0
GO
Isoform 2 (identifier: Q8NEP9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-105: Missing.
     451-453: PYE → LYK
     460-543: Missing.

Show »
Length:543
Mass (Da):63,040
Checksum:i370044FF6CA635E0
GO
Isoform 3 (identifier: Q8NEP9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-105: Missing.

Note: No experimental confirmation available.
Show »
Length:627
Mass (Da):72,997
Checksum:i0582DBDDF4E31B7E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti304I → T in BAF85643 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054223107N → D.1 PublicationCorresponds to variant rs17856649dbSNPEnsembl.1
Natural variantiVAR_054224137P → L.Corresponds to variant rs36012545dbSNPEnsembl.1
Natural variantiVAR_054225194H → N.1 PublicationCorresponds to variant rs17851955dbSNPEnsembl.1
Natural variantiVAR_026295515K → T.1 PublicationCorresponds to variant rs17856648dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018382105Missing in isoform 2 and isoform 3. 1 Publication1
Alternative sequenceiVSP_018383451 – 453PYE → LYK in isoform 2. 1 Publication3
Alternative sequenceiVSP_018384460 – 543Missing in isoform 2. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093163 mRNA. Translation: BAC04082.1.
AK292954 mRNA. Translation: BAF85643.1.
BX647423 mRNA. No translation available.
AC006130 Genomic DNA. No translation available.
BC022022 mRNA. Translation: AAH22022.2.
CCDSiCCDS12096.1. [Q8NEP9-1]
CCDS59329.1. [Q8NEP9-4]
RefSeqiNP_001166246.1. NM_001172775.1. [Q8NEP9-4]
NP_690004.4. NM_152791.4. [Q8NEP9-1]
UniGeneiHs.47712.

Genome annotation databases

EnsembliENST00000334241; ENSP00000334853; ENSG00000186300. [Q8NEP9-1]
ENST00000591539; ENSP00000467893; ENSG00000186300. [Q8NEP9-4]
GeneIDi148254.
KEGGihsa:148254.
UCSCiuc002lwn.5. human. [Q8NEP9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093163 mRNA. Translation: BAC04082.1.
AK292954 mRNA. Translation: BAF85643.1.
BX647423 mRNA. No translation available.
AC006130 Genomic DNA. No translation available.
BC022022 mRNA. Translation: AAH22022.2.
CCDSiCCDS12096.1. [Q8NEP9-1]
CCDS59329.1. [Q8NEP9-4]
RefSeqiNP_001166246.1. NM_001172775.1. [Q8NEP9-4]
NP_690004.4. NM_152791.4. [Q8NEP9-1]
UniGeneiHs.47712.

3D structure databases

ProteinModelPortaliQ8NEP9.
SMRiQ8NEP9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127136. 6 interactors.
IntActiQ8NEP9. 3 interactors.
STRINGi9606.ENSP00000334853.

PTM databases

iPTMnetiQ8NEP9.
PhosphoSitePlusiQ8NEP9.

Polymorphism and mutation databases

BioMutaiZNF555.
DMDMi221222537.

Proteomic databases

EPDiQ8NEP9.
MaxQBiQ8NEP9.
PaxDbiQ8NEP9.
PeptideAtlasiQ8NEP9.
PRIDEiQ8NEP9.

Protocols and materials databases

DNASUi148254.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334241; ENSP00000334853; ENSG00000186300. [Q8NEP9-1]
ENST00000591539; ENSP00000467893; ENSG00000186300. [Q8NEP9-4]
GeneIDi148254.
KEGGihsa:148254.
UCSCiuc002lwn.5. human. [Q8NEP9-1]

Organism-specific databases

CTDi148254.
GeneCardsiZNF555.
HGNCiHGNC:28382. ZNF555.
HPAiHPA053956.
HPA055430.
neXtProtiNX_Q8NEP9.
OpenTargetsiENSG00000186300.
PharmGKBiPA134956715.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8NEP9.
KOiK09228.
OMAiYSSTFRR.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8NEP9.
TreeFamiTF338854.

Enzyme and pathway databases

BioCyciZFISH:G66-32281-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii148254.
PROiQ8NEP9.

Gene expression databases

BgeeiENSG00000186300.
CleanExiHS_ZNF555.
ExpressionAtlasiQ8NEP9. baseline and differential.
GenevisibleiQ8NEP9. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN555_HUMAN
AccessioniPrimary (citable) accession number: Q8NEP9
Secondary accession number(s): A8KA89
, K7EQM2, Q8NA46, Q96MP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: January 20, 2009
Last modified: November 2, 2016
This is version 133 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.