ID KLDC9_HUMAN Reviewed; 349 AA. AC Q8NEP7; Q5SY56; Q6NXT9; Q6PKN4; Q8N5E1; Q8NA16; DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot. DT 04-JAN-2005, sequence version 2. DT 24-JAN-2024, entry version 152. DE RecName: Full=Kelch domain-containing protein 9; DE AltName: Full=Kelch/ankyrin repeat-containing cyclin A1-interacting protein; GN Name=KLHDC9; Synonyms=KARCA1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND INTERACTION WITH CCNA1. RX PubMed=15159402; DOI=10.1074/jbc.m401708200; RA Diederichs S., Baeumer N., Ji P., Metzelder S.K., Idos G.E., Cauvet T., RA Wang W., Moeller M., Pierschalski S., Gromoll J., Schrader M.G., RA Koeffler H.P., Berdel W.E., Serve H., Mueller-Tidow C.; RT "Identification of interaction partners and substrates of the cyclin A1- RT CDK2 complex."; RL J. Biol. Chem. 279:33727-33741(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RC TISSUE=Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANT RP THR-282. RC TISSUE=Pancreas, and Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SUBUNIT: Interacts with CCNA1. {ECO:0000269|PubMed:15159402}. CC -!- INTERACTION: CC Q8NEP7; O76003: GLRX3; NbExp=5; IntAct=EBI-12214879, EBI-374781; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q8NEP7-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8NEP7-2; Sequence=VSP_027808, VSP_027810; CC Name=3; CC IsoId=Q8NEP7-3; Sequence=VSP_027807, VSP_027809; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY601914; AAT09158.1; -; mRNA. DR EMBL; AK093268; BAC04114.1; -; mRNA. DR EMBL; AL591806; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471121; EAW52659.1; -; Genomic_DNA. DR EMBL; CH471121; EAW52662.1; -; Genomic_DNA. DR EMBL; BC022077; AAH22077.2; -; mRNA. DR EMBL; BC032482; AAH32482.1; -; mRNA. DR EMBL; BC066896; AAH66896.1; -; mRNA. DR CCDS; CCDS30919.1; -. [Q8NEP7-1] DR CCDS; CCDS41425.1; -. [Q8NEP7-2] DR RefSeq; NP_001007256.1; NM_001007255.2. [Q8NEP7-2] DR RefSeq; NP_689579.3; NM_152366.4. [Q8NEP7-1] DR AlphaFoldDB; Q8NEP7; -. DR SMR; Q8NEP7; -. DR BioGRID; 126019; 37. DR IntAct; Q8NEP7; 6. DR STRING; 9606.ENSP00000356990; -. DR iPTMnet; Q8NEP7; -. DR PhosphoSitePlus; Q8NEP7; -. DR BioMuta; KLHDC9; -. DR DMDM; 74751256; -. DR MassIVE; Q8NEP7; -. DR PaxDb; 9606-ENSP00000356990; -. DR PeptideAtlas; Q8NEP7; -. DR ProteomicsDB; 73194; -. [Q8NEP7-1] DR ProteomicsDB; 73195; -. [Q8NEP7-2] DR ProteomicsDB; 73196; -. [Q8NEP7-3] DR Antibodypedia; 34288; 94 antibodies from 16 providers. DR DNASU; 126823; -. DR Ensembl; ENST00000368011.9; ENSP00000356990.4; ENSG00000162755.14. [Q8NEP7-1] DR Ensembl; ENST00000392192.6; ENSP00000376030.2; ENSG00000162755.14. [Q8NEP7-2] DR GeneID; 126823; -. DR KEGG; hsa:126823; -. DR MANE-Select; ENST00000368011.9; ENSP00000356990.4; NM_152366.5; NP_689579.3. DR UCSC; uc001fxr.4; human. [Q8NEP7-1] DR AGR; HGNC:28489; -. DR CTD; 126823; -. DR GeneCards; KLHDC9; -. DR HGNC; HGNC:28489; KLHDC9. DR HPA; ENSG00000162755; Tissue enhanced (testis). DR MIM; 617375; gene. DR neXtProt; NX_Q8NEP7; -. DR OpenTargets; ENSG00000162755; -. DR PharmGKB; PA162393459; -. DR VEuPathDB; HostDB:ENSG00000162755; -. DR eggNOG; KOG0379; Eukaryota. DR GeneTree; ENSGT00390000011582; -. DR HOGENOM; CLU_068365_0_0_1; -. DR InParanoid; Q8NEP7; -. DR OMA; PEVAGQW; -. DR OrthoDB; 5384323at2759; -. DR PhylomeDB; Q8NEP7; -. DR TreeFam; TF337916; -. DR PathwayCommons; Q8NEP7; -. DR SignaLink; Q8NEP7; -. DR BioGRID-ORCS; 126823; 12 hits in 1137 CRISPR screens. DR ChiTaRS; KLHDC9; human. DR GenomeRNAi; 126823; -. DR Pharos; Q8NEP7; Tbio. DR PRO; PR:Q8NEP7; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; Q8NEP7; Protein. DR Bgee; ENSG00000162755; Expressed in right testis and 146 other cell types or tissues. DR GO; GO:0030332; F:cyclin binding; IPI:UniProtKB. DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2. DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller. DR InterPro; IPR015915; Kelch-typ_b-propeller. DR InterPro; IPR042941; KLDC9. DR PANTHER; PTHR47196; KELCH DOMAIN-CONTAINING PROTEIN 9; 1. DR PANTHER; PTHR47196:SF1; KELCH DOMAIN-CONTAINING PROTEIN 9; 1. DR Pfam; PF13415; Kelch_3; 2. DR SUPFAM; SSF50965; Galactose oxidase, central domain; 1. DR Genevisible; Q8NEP7; HS. PE 1: Evidence at protein level; KW Alternative splicing; Kelch repeat; Reference proteome; Repeat. FT CHAIN 1..349 FT /note="Kelch domain-containing protein 9" FT /id="PRO_0000300464" FT REPEAT 39..89 FT /note="Kelch 1" FT REPEAT 91..137 FT /note="Kelch 2" FT REPEAT 325..349 FT /note="Kelch 3" FT VAR_SEQ 176..263 FT /note="CYKQEGCHTASRSGHCAALLQTPGPHPGHQLLLFGGCNLAEPEVAGHWSHGK FT IKEEPPVAPHLMEQLARLVSSGQGSQKGPHGLRHHS -> WYGTLRPKPFTLIHTLEKQ FT KPKQISQAIYPPPHSSTLLPGEPTMFKLAELSTVLPSLLSHLPHCPMPLLHPSLARAVA FT LTFSRKPTQP (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:15489334" FT /id="VSP_027807" FT VAR_SEQ 230..288 FT /note="EEPPVAPHLMEQLARLVSSGQGSQKGPHGLRHHSCSVVGPFAVLFGGETLTR FT ARDTICN -> SFLSPQGGTTCCSSFDGTACKACEQWAGVPEGAPWTTASLMFCGRALC FT CAVWWRNSDQS (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15159402" FT /id="VSP_027808" FT VAR_SEQ 264..349 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:15489334" FT /id="VSP_027809" FT VAR_SEQ 289..349 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15159402" FT /id="VSP_027810" FT VARIANT 171 FT /note="S -> R (in dbSNP:rs11576830)" FT /id="VAR_034873" FT VARIANT 282 FT /note="A -> T (in dbSNP:rs1128750)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_050056" FT VARIANT 288 FT /note="N -> S (in dbSNP:rs1128750)" FT /id="VAR_034874" FT CONFLICT 83 FT /note="D -> G (in Ref. 2; BAC04114)" FT /evidence="ECO:0000305" SQ SEQUENCE 349 AA; 37754 MW; 034F41898BDE0BBB CRC64; MAVAVPPGRA AGSGWAWRPV ARDALLARAF HSCTELRGRF YLVGGLLAGG AREPSSDTVV FDPARGQAVR LGARGSPPRS HHDAAPVDGR WLCVVGGWDG SRRLATVTAL DTERGVWEAW TGTPGDCPPA GLSSHTCTRI SDRELQVAGR EGGIHTQRRY GSIYTLRLDP SARTYCYKQE GCHTASRSGH CAALLQTPGP HPGHQLLLFG GCNLAEPEVA GHWSHGKIKE EPPVAPHLME QLARLVSSGQ GSQKGPHGLR HHSCSVVGPF AVLFGGETLT RARDTICNDL YIYDTRTSPP LWFHFPCADR GMKRMGHRTC LWNDQLYLVG GFGEDGRTAS PQVCILDFI //